Title

Proposal for a Graduate Program in Rehabilitation Science Leading to the Degree of Doctor of Philosophy in Rehabilitation Science at the University of California, San Francisco.

Date of Preparation

December 20, 2013

Contact Information Sheet

Richard Souza, PT, PhD, ATC, CSCS (Program Director for Proposed PhD Program) Faculty Leader for Musculoskeletal Biomechanics track Associate Professor Department of Physical Therapy and Rehabilitation Science Department of Radiology and Biomedical Imaging Department of Orthopaedic Surgery Box 0946 (415) 514-8930 [email protected]

Linda Noble, PhD Faculty Leader for Clinically Informed Neuroscience track Professor and Vice Chair for Research Department of Physical Therapy and Rehabilitation Science Department of Neurological Surgery Box 0112 (415) 476-4850 [email protected]

Kimberly Topp, PT, PhD Professor and Chair Department of Physical Therapy and Rehabilitation Science Sexton Sutherland Endowed Chair in Human Anatomy Department of Anatomy Box 0736 (415) 476-9449 [email protected]

Linda Wanek, PT, PhD Professor and Chair Department of Physical Therapy San Francisco State University (415) 338-1939 [email protected]

Allison Guerin, MA (Staff Liaison) Assistant Director, Graduate Education and Accreditation Department of Physical Therapy and Rehabilitation Science Box 0736 (415) 514-6779 [email protected]

TABLE OF CONTENTS

SECTION 1: INTRODUCTION ...... 1 1.1. Aims and Objectives ...... 1 1.2. Historical Background ...... 3 1.3. Timetable for Development of the Program ...... 9 1.4. Relation of Proposed Program to Similar Programs on Campus ...... 10 1.5. Interrelationship of the Program with other University of California Institutions ...... 12 1.6. Department or Group that will Administer the Program ...... 13 1.7. Plan for Evaluation of the Program ...... 14 SECTION 2: PROGRAM ...... 15 2.1. Admissions Requirements and Undergraduate Preparation ...... 15 2.2. Foreign Language Competence...... 17 2.3. Program of Study ...... 17 2.4. Field Examination ...... 19 2.5. Qualifying Examination ...... 19 2.6. Dissertation ...... 20 2.7. Final Examination ...... 21 2.8. Explanation of Special Requirements ...... 21 2.9. Relationship of Master’s and Doctor’s Programs ...... 21 2.10. Special Preparation for Careers in Teaching ...... 21 2.11. Sample Program ...... 22 2.12. Normative Time from Matriculation to Degree ...... 24 SECTION 3: PROJECTED NEED ...... 25 3.1. Student Demand for the Program...... 25 3.2. Opportunities for Placement of Graduates ...... 26 3.3. Importance to the Discipline ...... 26 3.4. Ways in which the Program will Meet the Needs of Society ...... 28 3.5. Relationship of the Program to Research and/or Professional Interests of Faculty...... 28 3.6. Program Differentiation ...... 29 SECTION 4: FACULTY ...... 31 SECTION 5: COURSES ...... 34 SECTION 6: RESOURCE REQUIREMENTS ...... 40 SECTION 7: GRADUATE STUDENT SUPPORT ...... 42 SECTION 8: GOVERNANCE ...... 43 SECTION 9: CHANGES IN SENATE REGULATIONS ...... 44 APPENDICES...... 45

TABLES

Table 1: Institutions Offering PhD in Rehabilitation Science or Comparable Field ...... 5 Table 2: Alumni of the UCSF/SFSU DPTSc Program ...... 7 Table 3: UCSF Faculty Funding, Physical Therapy and Rehabilitation Science Department ...... 9 Table 4: Programs at Other UC Campuses ...... 13 Table 5: Admissions Requirements at Institutions with PhD in Rehabilitation Science Programs ...... 15 Table 6: Student Demand at Peer Institutions ...... 25 Table 7: Comparison of T-32 Grant Activity in 2012 and 2013...... 29 Table 8: Faculty in UCSF Department of Physical Therapy and Rehabilitation Science & SFSU Department of Physical Therapy ...... 31 Table 9: Faculty in the PhD Program Who Are Appointed in Other Departments at UCSF ...... 32

FIGURES

Figure 1: Committee Structure...... 19

SECTION 1: INTRODUCTION

1.1. Aims and Objectives

The UCSF Department of Physical Therapy and Rehabilitation Science, in collaboration with faculty from the Department of Physical Therapy at San Francisco State University (SFSU), seeks to offer a unique opportunity to study rehabilitation science. While the historical perspective for PhD programs within this field has been to address the clinical sciences, we envision a non-traditional approach that addresses the broader perspective of both basic and clinical sciences in the areas of musculoskeletal and neurorehabilitation. Such an approach offers substantial opportunity for cross-fertilization between the basic and clinical sciences and is in line with the definition of rehabilitation science, as put forth by the Institute of Medicine (IOM).

As defined by the IOM, rehabilitation science encompasses “basic and applied aspects of health services, social sciences, and engineering as they relate (1) to the restoration of functional capacity in a person and (2) the interaction of that person with the surrounding environment”1.

This proposal aims to establish the first PhD in Rehabilitation Science program at a publicly funded higher education institution in the State of California. The PhD Program in Rehabilitation Science is a logical and much needed step in the development of the Graduate Program in Physical Therapy at UCSF and fills an important gap for the UCSF Graduate Division. The existing joint UCSF/SFSU Doctor of Physical Therapy Science (DPTSc) program will be phased out as the new PhD Program in Rehabilitation Science is implemented.

The PhD in Rehabilitation Science program leverages the current collaboration with San Francisco State University, by including a wide variety of faculty with diverse knowledge and expertise in the field of rehabilitation science. The new PhD program will contribute to the discipline of rehabilitation science while also furthering the health sciences, advancing healthcare goals of the university, and increasing consumer access to evidence based health care. The proposed PhD program is unique in the State of California, as well as the University of California system. Within UCSF, the PhD program maximizes the integration of the depth and breadth of offerings and opportunities for training in a number of interdisciplinary areas related to rehabilitation science.

The proposed size of the program will begin with two students admitted every other year. This model was established given the number of current faculty in the Department of Physical Therapy and Rehabilitation Science and the funding available to support PhD students. We anticipate a moderate growth with a maximum size of 2 students admitted every year (8-10 students in the program at any given time). This size will allow us to provide adequate funding and mentorship support to students. With more funded faculty and a T-32 training grant, there may be potential for the program to admit more students. The projected size of the program is in line with the size of institutions with similar degree programs (see Table 1 on page 6).

The specific aims and objectives of the PhD program are as follows:

1. Create a preeminent center of learning and discovery in rehabilitation science at the doctoral level. 2. Leverage the expertise of faculty within the academic program at both UCSF and SFSU to strengthen and expand the training in rehabilitation sciences available to students and develop academic areas of focus that draw on the strengths of our faculty and the campus. 3. Take advantage of the highly interdisciplinary nature of UCSF and the diversity at SFSU to expand the learning opportunities and enrich the collaborative science research experience for our graduate students. 4. Enhance interactions with the broader academic community in rehabilitation science centers of excellence at the national level.

1 Committee on the Offshoring of Engineering, Institute of Medicine, Edward N. JB, Pope AM. Enabling America: Assessing the role of rehabilitation science and engineering National Academies Press, p. 25. Accessible from: http://www.nap.edu/catalog.php?record_id=5799

1

A central goal of the program is to capitalize on the highly interdisciplinary nature of UCSF and create an academic program that integrates multiple disciplines. PhD students will have the opportunity to participate in specialized training in areas that will ensure distinction of the PhD program at UCSF. These specialized areas include:

Musculoskeletal Biomechanics Musculoskeletal Biomechanics is one of the foundational sciences of physical therapy and rehabilitation science. Motion analysis and applied biomechanics have roots from over a century ago; however, with recent advances in technology, new and innovative ways to assess and record human movement are being developed. Furthermore, reduction in costs for some biomechanics research methods is resulting in larger numbers of laboratories performing these investigations. The result has been an explosion in high-quality biomechanics research performed across the country and beyond. These discoveries are being translated immediately to the clinic for improved patient care.

The proposed program will train new investigators on the latest advancements in musculoskeletal biomechanics and prepare them for careers in research in academia and industry. General areas of study in the Musculoskeletal Biomechanics track include: 1) assessment of normal and pathological human movement using motion analysis and kinematic imaging techniques, and 2) quantitative imaging of the musculoskeletal system, including advanced quantitative magnetic resonance imaging (MRI), spiral computed tomography (CT), high-resolution peripheral quantitative computed tomography (HRpqCT), and Positron Emission Tomography (PET). The UCSF Human Performance Center is a state-of-the-art motion analysis laboratory with a 10-camera VICON optical motion capture system and three AMTI force platforms for measurement of ground reaction forces. This laboratory, which is dedicated to research, is the only active motion capture system at UCSF. The UCSF Musculoskeletal Quantitative Imaging Research (MQIR) group is a large group of interdisciplinary researchers dedicated to advancing quantitative imaging for clinical implementation and development of post-processing and training procedures for research and clinical use. This group has access to two 3T research-dedicated MR scanners, one whole-body 7T MRI scanner, HRpqCT, CT, PET, PET-MR, and micro-CT scanners. This infrastructure and network of expertise, in combination with the patient population at UCSF, creates an ideal environment for training research scientists in the area of musculoskeletal biomechanics and rehabilitation science.

Clinically Informed Neuroscience The field of neurorehabilitation has made significant advances over the past two decades in developing metrics to assess functionality and applying these metrics to treatment paradigms. Despite this progress, we have yet to fully appreciate the guiding principles underlying activity-based neuroplasticity and restoration of function. The ability to transform how rehabilitation is implemented in the clinic is dependent upon defining these basic principles in the context models of neurotrauma, neuroinflammation, and neurodegenerative disease, with an emphasis on the translation of these laboratory findings to the clinical arena.

The Clinically Informed Neuroscience track will offer two pathways of investigation. The first pathway is invested in a clinically-based platform, which will focus on neural injury and neurodegenerative disease, with the objectives of assessing disability, applying new technologies to improve functionality, and testing the underlying basis of activity-based restoration of function and outcomes research. To achieve these objectives, students will have access to state-of-the art motion analysis; robotics, including lower extremity exoskeletons with biofeedback to support locomotion; specialized equipment such as the G-trainer by Alter G, an anti-gravity treadmill to support learning-based training; and the motion analysis equipment in the PT Movement Research Laboratory at San Francisco State University. Students will have the opportunity to interrogate the functionality of the brain and neuroplasticity through state-of-the art MRI-based technologies and transmagnetic stimulation in the Departments of Radiology and Biomedical Imaging and Neurology, which oversees a rich patient database for stroke and multiple sclerosis for outcomes research. In addition, the Department of Physical Therapy at SFSU provides students with opportunities to participate in research on balance-based torso weighting interventions for patients with multiple sclerosis and a recently developed program to study movement accuracy. Access to the UCSF patient population, through the collaborative departmental efforts of Physical Therapy and Rehabilitation Science, Neurology and Neurological Surgery, will position the students’ science at the forefront of clinical care.

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The second pathway within the Clinically Informed Neuroscience track is devoted to laboratory-based translational research that will focus on experimental models of neurodegeneration and chronic neuroinflammation and the interplay between defined activity and key molecular events driving motor, sensory and cognitive decline or recovery. This pathway is supported by laboratories that are uniquely positioned to study structure and function and the molecular basis for damage and reparative processes. These laboratories combine high-level imaging microscopes with molecular biology platforms to study structure and function. Essential to this research is the Neurobehavioral Core for Rehabilitation Research, a facility operated by the Department of Physical Therapy and Rehabilitation Science that provides state-of-the art instrumentation to fully profile motor, sensory and cognitive function and assess voluntary or forced activity in the context of disease-based animal models. The Core not only provides ample opportunity for students to measure neurological function, but also to address activity as a determinant of outcome. Additional support for this pathway will come from UCSF-sponsored Core services, including: 1) the Biological Imaging Developmental Center that provides instrumentation for novel imaging, including spinning disk confocal microscopy and confocal microscopy with capability for multi-color and spectral imaging, 2) the Parnassus Flow Cytometry Core, and 3) the Mouse Genetics Core, operated by the Diabetes Center. This pathway will interface with the graduate programs in Neuroscience, Biomedical Sciences and Stem Cell Biology. Students will have the opportunity to attend classes and seminars within these programs including mini- courses that are uniquely tailored to specific research topics.

Falling between the Musculoskeletal Biomechanics track and the Clinically Informed Neuroscience track is the cross-cutting field of chronic pain. UCSF has a strong basic science group in the neural underpinnings of pain physiology, housed primarily in the Neuroscience and Biomedical Science graduate programs. There are also strong pre-clinical and clinical programs in the treatment of acute and chronic pain, housed primarily in the Departments of Anatomy, Physiology, Anesthesia, Neurology, Physiological Nursing, and Psychiatry. What is less robust, however, is the linkage between the basic science of pain physiology and the clinical care of patients in musculoskeletal and neurological rehabilitation. The Department of Physical Therapy and Rehabilitation Science is a participant in the Center of Excellence in Pain Education, and contributes to the case study components of the educational program. Experienced faculty in pain science have expressed their support of the PhD program in Rehabilitation Science, and this collaboration will help forge research linkages between the basic science laboratories and the clinical care of patients with acute or chronic pain.

1.2. Historical Background

Historical Development of the Field

With the increased number of aging individuals in society and the survival of patients with previously fatal illnesses, organ transplants, trauma, and cancer, patients need education and rehabilitation to resume independence and maximize the quality of life. In addition to reform in health care delivery and managed care, the expanding population with health care needs requires that scientific knowledge and technology continue to advance and be transitioned rapidly into clinical care.

The field of rehabilitation science is interdisciplinary and seeks to understand the relationships among physiological, environmental, occupational, and psychosocial causes, course, and consequences of functional disability and how to improve quality of life by enabling human function and performance. Basic and applied research from the health sciences, social sciences and other related fields are directed towards enhancing physical and psychosocial functioning and quality of life of people with disabilities2.

As a result of the efforts to help soldiers recovering from injuries after World War II, the field of rehabilitation science was officially recognized as a subspecialty in 1946. The field expanded quickly beyond the use of orthotics

2 Committee on the Offshoring of Engineering, Institute of Medicine, Edward N. JB, Pope AM. Enabling America: Assessing the role of rehabilitation science and engineering National Academies Press, p. 14. Accessible from: http://www.nap.edu/catalog.php?record_id=5799

3 and assistive devices to include the use of therapies and medications to increase mobility and function. At the national level, the National Institute of Child and Health Development (NICHD) was established in 1962 to meet a number of pressing priorities, including responding to the need for understanding mental and intellectual disabilities. Development of the field of disability research soon led to studies that not only sought to understand disability, but to identify or develop ways to improve the health and quality of life for individuals suffering from disabilities3.

After the implementation of the Americans with Disabilities Act in 1990, Congress passed responsibility for rehabilitation science research to the National Institutes of Health. In 1991, the National Center for Medical Rehabilitation Research (NCMRR) was founded as a Center within the NICHD. The NCMRR is committed to funding research in rehabilitation science, offering numerous mechanisms for funding, including postdoc awards (F-32), career development awards (K-awards), training grants (T-32) and various research awards (R01, R03, R21, etc.). Over the past 22 years, the NCMRR has been the major galvanizing force for rehabilitation research, and has made substantial contributions to the field of medical rehabilitation research using their original interdisciplinary research priorities as guidelines that are still used today. These research priorities include4:

● Improving functional mobility ● Promoting behavioral adaptation to functional losses ● Assessing the efficacy and outcomes to medical rehabilitation therapies and practices ● Developing improved assistive technology ● Understanding whole body system responses to physical impairments and functional changes ● Developing more precise methods of measuring impairments, disabilities, and societal and functional limitations ● Training research scientists in the field of rehabilitation

Given the position of the Department of Physical Therapy and Rehabilitation Science at UCSF and the scholarly interests and NIH-level funding of its faculty, the Department is poised to offer a PhD program that will address these research priorities in rehabilitation science.

Historical Development of Doctoral Programs in the Department of Physical Therapy and Rehabilitation Science

Currently, the Department of Physical Therapy and Rehabilitation Science offers both a joint UCSF/SFSU Entry-level Doctor of Physical Therapy (DPT) degree and a joint UCSF/SFSU Doctor of Physical Therapy Science (DPTSc) degree. The Entry-level Doctor of Physical Therapy degree is a 3-year joint program between UCSF and San Francisco State University. In 2013, the program received re-accreditation through 2021 from the Commission on Accreditation in Physical Therapy Education (CAPTE). The program runs for 36 continuous months and includes 32 weeks of full- time clinical affiliations. This program accepts 50 students per year and is designed to prepare scholarly clinicians. The curriculum is built on a strong theoretical foundation in basic, medical and applied sciences. Critical thinking and clinical reasoning skills are developed within an integrated program that prepares students to work collaboratively with patients across the lifespan to improve health and wellness, address disability challenges, and optimize function. Graduates excel in the National Licensing Examination and are considered top applicants for positions in physical therapy practice.

The Doctor of Physical Therapy Science (DPTSc) degree was originally created in 1999, and was designed for experienced clinicians to return to the University to expand their academic studies and develop their skills as clinical researchers, educators, and clinical specialists. At the time of the original proposal, the DPTSc was the only research-based doctoral program in physical therapy for the University of California or the California State University. The DPTSc program was the proposed degree, rather than a PhD program, after careful consideration

3 National center for medical rehabilitation research celebrates its 20th anniversary http://www.nichd.nih.gov/news/resources/spotlight/Pages/050511-NCMRR-anniversary.aspx. Accessed 12/20/2013, 2013. 4 National center for medical rehabilitation research celebrates its 20th anniversary http://www.nichd.nih.gov/news/resources/spotlight/Pages/050511-NCMRR-anniversary.aspx. Accessed 12/20/2013, 2013.

4 of the resources allocated for teaching and research, which were more in line with an advanced professional doctoral degree. However, as the health care sciences have evolved, new faculty members have been recruited to support a stronger research effort. This success has resulted in the highest level of extramural funding achieved in the history of the Department of Physical Therapy and Rehabilitation Science. With the expansion of our faculty and research, we are now optimally positioned to provide a PhD program that would support an academic doctorate-level curriculum in rehabilitation science.

Of note, there is an increasing trend in the field of Physical Therapy and Rehabilitation Science to move away from advanced clinical doctoral degrees such as the DPTSc, and toward research degrees. Currently, the advanced clinical doctoral degree available in the United States is the Doctor of Physical Therapy Science (DPTSc) / Doctor of Science in Physical Therapy (DScPT). In 2010, the American Physical Therapy Association’s (APTA) website listed eleven advanced clinical doctorate programs and in 2013, this number had reduced to seven programs. UCSF/SFSU is the only institution in the country offering a DPTSc degree, while seven universities offer other advanced clinical doctorate programs:

1. Andrews University, Berrien Springs, MI (DScPT in manual physical therapy) 2. Boston University, Boston, MA (ScD in rehabilitation sciences) 3. Loma Linda University, Loma Linda, CA (DScPT in physical therapy) 4. Oakland University, Rochester, MI (DScPT in physical therapy) 5. Texas Tech University Health Sciences Center, Lubbock, TX (ScD in physical therapy) 6. University of Oklahoma Health Sciences Center, Oklahoma City, OK (DSc in rehabilitation sciences) 7. University of Tennessee Health Sciences Center, Memphis, TN (ScD in physical therapy)

Two post-professional graduate educational and research degrees are available in physical therapy: the Doctor of Philosophy (PhD) or Doctor of Science (DSc/ScD). In 2013, the APTA’s website listed 43 research doctoral programs (8 with concentrations in physical therapy and 22 in rehabilitation science)5. Currently, no other public institution in California offers a PhD in Rehabilitation Science. The institutions that offer a research doctoral degree in California are all private institutions, including:

1. The Ola Grimsby Institute, San Diego, CA (PhD in Orthopedic Manual Therapy) 2. University of Southern California, Los Angeles, CA (PhD in Biokinesiology) 3. Loma Linda University, Loma Linda, CA (PhD in Rehabilitation Science)

Across the country, the institutions that offer a PhD in Rehabilitation Science are primarily housed in the large, state flagship Universities located in the Midwest and along the East Coast. Included in the table below is the current list of PhD in Rehabilitation Science programs, along with PhD programs that have similarities to the proposed PhD program at UCSF. The proposed program at UCSF is highlighted in green for comparison purposes.

Table 1: Institutions Offering PhD in Rehabilitation Science or Comparable Field

Average Training Grants Awarded Training Grants Institution State Type Degree Enrollment to the University in Rehabilitation PhD in Rehabilitation 3-4 per 2012: $0 (n=0) 2012: $0 Drexel University PA Private Sciences year 2013: $0 (n=0) 2013: $0 PhD in Rehabilitation 0-2 per 2012: $0 (n=0) 2012: $0 Duquesne University PA Private Science year 2013: $0 (n=0) 2013: $0 PhD in Rehabilitation 1-2 per 2012: $0 (n=0) 2012: $0 Loma Linda University CA Private Science year 2013: $0 (n=0) 2013: $0 Medical University of PhD in Health & 3-6 per 2012: $3,523,823 (n=14) 2012: $0 SC Public South Carolina Rehabilitation Science year 2013: $3,603,611 (n=13) 2013: $0

5 Directory of postprofessional doctoral and graduate programs http://www.apta.org/PostprofessionalDegree/DoctoralGraduatePrograms/. Accessed 12/3/2013, 2013.

5 Average Training Grants Awarded Training Grants Institution State Type Degree Enrollment to the University in Rehabilitation MGH Institute of Health PhD in Rehabilitation 2012: $5,764,405 (n=21) 2012: $0 MA Private 6 per year Professions Sciences 2013: $6,589,139 (n=19) 2013: $0 Northwestern PhD in Movement & up to 2012: $8,054,128 (n=32) 2012: $708,233 IL Private University Rehabilitation Science 6 per year 2013: $7,325,680 (n=30) 2013: $626,729 PhD in Health & 2012: $2,973,598 (n=13) 2012: $0 Ohio State University OH Public Rehabilitation 3 per year 2013: $3,268,764 (n=16) 2013: $0 Sciences The University of North PhD in Human 4-8 per 2012: $15,722,227 (n=57) 2012: $318,397 NC Public Carolina at Chapel Hill Movement Science year 2013: $14,818,902 (n=50) 2013: $432,763 Texas Tech University PhD in Rehabilitation 2-5 per 2012: $0 (n=0) 2012: $0 TX Public Health Sciences Center Sciences year 2013: $0 (n=0) 2013: $0 University of Alabama at PhD in Rehabilitation 2012: $4,560,500 (n=22) 2012: $195,471 AL Public 4 per year Birmingham Science 2013: $5,275,467 (n=21) 2013: $262,501 University at Buffalo, PhD in Rehabilitation 1-2 per 2012: $607,953 (n=4) 2012: $0 The State University of NY Public Science year 2013: $805,318 (n=5) 2013: $0 New York University of California, PhD in Rehabilitation 2 every 2012: $18,004,693 (n=57) 2012: N/A CA Public San Francisco Science other year 2013: $18,350,321 (n=55) 2013: N/A University of Colorado PhD in Rehabilitation 2012: $6,919,474 (n=26) 2012: $0 CO Public 3 per year Denver Science 2013: $7,560,108 (n=31) 2013: $0 PhD in Biomechanics 2-4 per 2012: $346,526 (n=2) 2012: $67,866 University of Delaware DE Public & Movement Science year 2013: $394,142 (n=2) 2013: $155,291 PhD in Rehabilitation 3-4 per 2012: $2,464,065 (n=13) 2012: $205,731 University of Florida FL Public Science year 2013: $1,948,748 (n=11) 2013: $0 PhD in Rehabilitation 1-2 per 2012: $7,195,268 (n=25) 2012: $0 University of Iowa IA Public Science year 2013: $7,263,834 (n=26) 2013: $0 University of Kansas PhD in Rehabilitation 3-8 per 2012: $1,604,541 (n=4) 2012: $214,931 KS Public Medical Center Science year 2013: $1,530,652 (n=8) 2013: $174,859 PhD in Rehabilitation 4-7 per 2012: $2,185,694 (n=11) 2012: $0 University of Kentucky KY Public Science year 2013: $1,744,988 (n=10) 2013: $0 PhD in Physical 2012: $3,841,749 (n=18) 2012: $0 University of Maryland MD Public 12 per year Rehabilitation Science 2013: $3,562,960 (n=17) 2013: $0 University of Medical PhD in Rehabilitation under 10 2012: $1,927,366 (n=13) 2012: $0 AZ Private Sciences Arizona Science per year 2013: $1,182,950 (n=8) 2013: $0 PhD in Rehabilitation 2-3 per 2012: $9,868,557 (n=34) 2012: $256,351 University of Minnesota MN Public Science year 2013: $9,903,968 (n=31) 2013: $274,442 PhD in Rehabilitation 2012: $12,620,803 (n=57) 2012: $28,157 University of Pittsburgh PA Private Science 2013: $13,516,467 (n=58) 2013: $28,157 University of Southern 2012: $3,058,674 (n=10) 2012: $0 CA Private PhD in Biokinesiology 6 per year California 2013: $2,104,168 (n=8) 2013: $0 University of Texas PhD in Rehabilitation 2-5 per 2012: $1,943,937 (n=9) 2012: $0 TX Public Medical Branch Sciences year 2013: $2,082,273 (n=9) 2013: $0 University of PhD in Rehabilitation 2012: $21,983,127 (n=61) 2012: $0 WA Public Washington Science 2013: $20,272,808 (n=56) 2013: $0 Virginia Commonwealth PhD in Rehabilitation 1-2 per 2012: $1,801,414 (n=6) 2012: $0 VA Public University & Movement Science year 2013: $1,384,248 (n=6) 2013: $0 Washington University PhD in Movement 2-3 per 2012: $16,949,967 (n=50) 2012: $153,637 MO Private at St. Louis Science year 2013: $16,764,449 (n=50) 2013: $143,012

The only PhD in Rehabilitation Science programs offered in the west include:

1. Loma Linda University 2. Texas Tech University Health Sciences Center 3. University of Colorado at Denver 4. University of Medical Sciences Arizona

6 5. University of Texas Medical Branch 6. University of Washington

Of these, only the Universities of Washington, Colorado, and Texas are public institutions.

The DPTSc degree was designed to educate scholarly clinicians, and to graduate individuals who would be prepared to become academic faculty in Physical Therapy programs or who could return as leaders in the clinical setting. The program has been successful in graduating individuals who were able to achieve these two goals; however, we have struggled to develop graduates who are competitive for research positions in comprehensive doctorate universities, based on the Carnegie Classification system. Examples of the career placement of DPTSc graduates is outlined in the table below. It’s worth noting that the DPTSc graduates who have been successful in receiving NIH extramural funding have been those who were recruited into the Department of Physical Therapy and Rehabilitation Science at UCSF. These faculty have been provided the mentorship and guidance needed to successfully secure NIH extramural funding to develop independent research agendas.

Table 2: Alumni of the UCSF/SFSU DPTSc Program

Publishing Alumnus Current Position NIH Funding Activity Assistant Professor, Samuel Merritt Boyd, Benjamin Yes • None University, Physical Therapy Program Program Director, Physical Therapy Assistant Dolberg, Rebecca Yes • None Program, Carrington College Assistant Professor, UCSF Departments of • Graduated August 2013; plans Fitzsimmons, Amber Physical Therapy & Rehabilitation Science Yes to pursue funding in the next year and Anatomy Assistant Adjunct Professor, Samuel Merritt Gilleran, Tim No • None University, Physical Therapy Program Associate Professor, Samuel Merritt Gorman, Sharon Yes • None University, Physical Therapy Program • BIRCWH K-12 Award Associate Clinical Professor, UCSF • CTSI KL2 Award Katzman, Wendy Department of Physical Therapy & Yes • R01 grant from the National Rehabilitation Science Institute on Aging Kinder, Jennifer Therapist, Apex Physical Therapy Yes • None Assistant Adjunct Professor, Samuel Merritt Rivera, Monica University, Physical Therapy Program; No • None Lecturer, UCSF & SFSU Assistant Professor, UCSF Departments of Smoot, Betty Physical Therapy & Rehabilitation Science Yes • CTSI KL2 Award and Anatomy Lead Therapist, Harrison Medical Center; Wampler, Meredith Yes • None Adjunct Faculty, University of Puget Sound

The PhD in Rehabilitation Science degree is needed at UCSF to meet the growing demand for faculty who are able to perform independent, original research to further the field of rehabilitation science. The DPTSc degree was targeted for clinician-scientists, whose research success was dependent on working with a pre-established research team. The PhD Program, however, would allow the Department to train scientists who will complete postdoctoral training and take their research to another comprehensive doctorate university, and be a leader in his/her respective field. Graduates will be secure in starting their own research programs at other institutions with the tools necessary to collaborate with other scientists in pursuing extramural funding.

We believe the PhD program, compared to the DPTSc program, is more closely aligned with the broader mission of UCSF - advancing health worldwide. The aim of this PhD program is to move the field of rehabilitation science

7 research forward, and this type of work is well suited for an institution such as UCSF.

The primary difference between the proposed PhD degree and the current DPTSc degree is the level of rigor expected of students. This rigor is reflected in the increased required number of research units, the lengthened time for completion of the program, and the expectation that students will be performing independent, original research, rather than joining a current research project at UCSF. We believe this model is more in line with other PhD programs at UCSF. Additionally, the PhD program would allow us to recruit students who are interested in a PhD degree, but may possess a degree outside the field of physical therapy.

Departmental Strength in the Field

When the outpatient physical therapy facility at the UCSF Medical Center closed in 2003, the Department of Physical Therapy and Rehabilitation Science was established within the School of Medicine with an objective of opening a clinical practice. The Department underwent a number of moves thereafter - from 374 Parnassus to 7th Avenue to 9th Avenue and then Mt. Zion, where space was allocated to 1701 Divisadero and Hellman. Under the new chair, Dr. Kimberly Topp, the Department consolidated its efforts at 1701 Divisadero, and thereafter relocated to new space, dedicated to both an outpatient clinic and health and wellness center, at the Mission Bay campus.

The Department underwent major changes over the last decade. While the Department historically placed great emphasis on teaching, clinical work and research, the five core faculty in the Department had substantial teaching loads and extramural funding for research was very limited. However, it is noteworthy that Nancy Byl, PT, MPH, PhD, although lacking independent NIH-funding, established an internationally recognized expertise in focal dystonia.

With the initiation of joint appointments with other departments at UCSF, the face of the Department of Physical Therapy and Rehabilitation Science began to change with the recruitments of Linda Noble, Susanna Rosi and Richard Souza into the Academic Senate series. These faculty members have successfully secured and maintained extramural funding, including NIH support, and have subsequently served as the backbone for building research programs within the Department that are focused on musculoskeletal and neurological rehabilitation. Additionally, the Department hired three graduates from the DPTSc program into faculty positions - Wendy Katzman as a Clinical Professor, and Betty Smoot and Amber Fitzsimmons as Adjunct Professors. Dr. Katzman and Dr. Smoot have subsequently received funding for their research, including a KL2 award and a R01 grant from the National Institute on Aging to study the effects of exercise on functional capabilities in persons with hyperkyphosis.

The Department of Physical Therapy and Rehabilitation Science currently has 12 faculty members with primary appointments in the Department, 3 with a primary focus in teaching, 5 with a primary focus in research, and 4 with a primary focus in clinical practice. Of these, 4 are members of the Academic Senate, and 1 is an Emeritus Professor. The Department currently has 2 state-funded faculty FTE’s. Research faculty maintain laboratory space at the China Basin (Richard Souza), SFGH (Susanna Rosi), Mission Bay (Wendy Katzman) and Parnassus (Linda Noble) campuses. Department faculty members were awarded $19 million in grants and contracts in 2011/12, placing the Department five times higher than the national average of $3.5 million. Of note, faculty hold joint appointments and submit grant applications through the Departments of Neurological Surgery, Orthopaedic Surgery or Radiology, as well as through the Department of Physical Therapy and Rehabilitation Science. The table below lists only the awards submitted through the Department of Physical Therapy and Rehabilitation Science.

8 Table 3: UCSF Faculty Funding, Physical Therapy and Rehabilitation Science Department

Year Direct Cost Indirect Cost Total FY09 $191,561 $40,215 $231,776 FY10 $250,000 $119,900 $369,900 FY11 $249,828 $113,088 $362,916 FY12 $259,900 $116,643 $376,543 FY13 $1,046,879 $479,158 $1,526,037 FY14 $1,164,012 $559,925 $1,723,937 FY15 $1,014,281 $575,444 $1,589,725 FY16 $717,863 $417,154 $1,135,017 FY17 $632,156 $367,014 $999,170 Total $5,526,480 $2,788,540 $8,315,020 Note: FY14 - FY17 are estimates

The Department of Physical Therapy at San Francisco State University has five faculty members, and the FTEs for SFSU faculty are state-supported. All five faculty are members of the SFSU Academic Senate. Two of the five faculty have a primary focus on research, while the remaining three focus on teaching and administration. In 2011/12, SFSU faculty were awarded $828,726 in grants and contracts. Two faculty (Sandy Radtka and Diane Allen) conduct research in the PT Movement Research Lab at SFSU, which is equipped with a motion analysis system, forceplates, electromyography and GaitRite system. Diane Allen, Associate Professor, received an NIH AREA grant to study the effects of torso weighting on patients with multiple sclerosis and a Patient Centered Outcomes Research Initiative (PCORI) grant to study the effects of perceived movement ability.

1.3. Timetable for Development of the Program

The goal is to matriculate the first students and begin classes in the fall of 2015. Prior to that time, the program must seek review and approval of the Deans at UCSF, the Graduate Council, Academic Senate, and the Chancellor. Then, a system-wide review by the Coordinating Committee on Graduate Affairs (CCGA) and the University of California Office of the President (UCOP) will begin. An extensive curriculum is currently in place in physical therapy and rehabilitation science at the doctoral level. Many faculty members teach in the existing physical therapy degree programs and additional faculty recruitments will be strategically chosen according to training needs in the PhD program.

Proposed Approval Process Timeline:

● Campus Review ○ Relevant Deans: Graduate Division/SOM – November 2013 (1 month) ○ Graduate Council: February 2014 (1 month) ○ Divisional Academic Senate: February-March 2014 (2 months) ○ Chancellor: March 2014 (1 month) ● System-wide Review ○ Coordinating Committee on Graduate Affairs: April-June 2014 (3 months) ○ UCOP Provost/Sr. VP, President Approve: September 2014 (1 month) ● Program Launch ○ New Program Announced and Applications Received: Late Fall 2014 ○ Program Admissions: Winter/Spring Quarter 2015 ○ Program Begins: Fall Quarter 2015

On August 1, 2013, Chris Cullander, Director in the Office of Institutional Research, confirmed with the Western Association of Schools and Colleges (WASC) that the PhD in Rehabilitation Science Program does not require a substantive change review. The PhD Program is currently accounted for in the UCSF Campus Enrollment Plan, with projected students enrolled in the 2015-16 academic year and each year thereafter.

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The establishment of the PhD in Rehabilitation Science will coincide with the dis-establishment of the Doctor of Physical Therapy Science degree program. We do not plan to enroll new DPTSc students while the PhD program is under review. The existing student in the DPTSc program will continue in the program until graduation, which is anticipated for 2016.

1.4. Relation of Proposed Program to Similar Programs on Campus

The proposed PhD program will be most closely related to four current doctoral programs at UCSF. It is expected that the programs will be complementary rather than competitive.

1) PhD in Neuroscience Students interested in the PhD in the Neuroscience program may also be interested in the proposed PhD in Rehabilitation Science program, which will have an option for a neuroscience emphasis. While there is likely to be synergism between the two programs in that both utilize clinically-relevant animal models of CNS injury/disease, the proposed program is distinguished by its emphasis on the intersection between cell injury, inflammation, neuroplasticity, stem cell biology, and activity-based restoration of function. The latter is a key distinguishing feature of this proposed program where there will be opportunity to study topics such as patterned activity to maximize plasticity and behavioral recovery, and synergism or incompatibility between combinatorial approaches that merge pharmacologic-induced plasticity with defined patterns of rehabilitation. Examples include voluntary or forced locomotion or reaching tasks, and fundamental consequences of rehabilitation on neuroinflammatory pathways, delayed cell loss, stem cell-directed axonal plasticity, and wound healing events that govern recovery processes.

Courses offered within Neuroscience that we anticipate would be of interest to our PhD students: • NS 219 Topics in Basic or Translational Neuroscience • NS 225 Neurobiology of Disease • NS 245 Behavioral Neuroscience

Courses offered within the PhD in Rehabilitation Science that may be of interest to students in Neuroscience: • RS 100 Introduction to Rehabilitation Science • RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan

2) PhD in Biomedical Sciences Neurobiology in the Biomedical Sciences program is one of eight thematic areas. The Biomedical Sciences program may attract similar applicants as those interested in the proposed PhD in Rehabilitation Science program. A key distinction of the proposed PhD program in Rehabilitation Science is an emphasis on activity-based restoration of function in the context of clinically-relevant animal models of acute neural injury and reparative processes, neurodegenerative diseases, and neuroinflammation in the adult and/or developing central nervous system.

Courses offered within Biomedical Sciences that we anticipate would be of interest to our PhD students: ● BMS 225A Human Disease: Technologies and Biomedical Applications ● BMS 225B Tissue and Organ Biology ● BMS 255 Basic Genetics and Genomics ● BMS 260 Cell Biology

Courses within the PhD in Rehabilitation Science that may be of interest to students in Biomedical Sciences: ● RS 100 Introduction to Rehabilitation Science ● RS 130 Basics in Musculoskeletal Imaging ● RS 150 Gross and Regional Anatomy ● RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan ● RS 400 Topics in Clinically Informed Neuroscience (e.g. Challenges in Translation of Science to the Clinic)

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3) PhD in Epidemiology and Translational Science Applicants interested in handling large data sets from existing studies may be interested in the PhD program in Epidemiology and Translational Science, as well as the proposed PhD in Rehabilitation Science program. The Program in Epidemiology and Translational Science educates students in methods for studying disease etiology and prevention, evaluating treatment efficacy, and implementing evidence-based clinical care and population health. The Department of Physical Therapy and Rehabilitation Science has faculty who work with large datasets in bone health, orthopaedics, and oncology, and there may be some fortuitous overlap in methodology in evaluating treatment efficacy and prevention studies. We anticipate that students in Rehabilitation Science will enroll in courses in biostatistics and research design, offered by the Department of Epidemiology. Furthermore, students in Epidemiology and Translational Science will be welcomed into courses within the PhD program in Rehabilitation Science.

Courses offered within Epidemiology that we anticipate would be of interest to our PhD students: ● EPI 150.03/202 Designing Clinical Research ● TICR Summer Clinical Research Workshop ○ EPI 150.03 Designing Clinical Research ○ EPI 218 Database Management Systems for Clinical Research ○ EPI 227 Building a Career in Clinical Research

Courses within the PhD in Rehabilitation Science that may be of interest to students in Epidemiology: ● RS 100 Introduction to Rehabilitation Science ● RS 130 Basics in Musculoskeletal Imaging ● RS 150 Gross and Regional Anatomy ● ANA 207 Neuroscience ● RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan ● RS 400 Topics in Clinically Informed Neuroscience (e.g. Challenges in Translation of Science to the Clinic)

4) PhD in Bioengineering Students interested in the proposed PhD in Rehabilitation Science may also be interested in the joint UCSF/UC Berkeley PhD in Bioengineering. While the current areas of study within the PhD in Bioengineering include similarities, the two programs differ in the emphasis placed on engineering versus rehabilitation. For example, one of the emphases for the PhD in Bioengineering is in Biomechanics. Specific projects within the Biomechanics emphasis are rooted in tissue and/or fluid mechanics and involve cellular or tissue level investigations. In contrast, students enrolled in the PhD in Rehabilitation Science program would likely focus on applied or clinical biomechanics, using whole body technology, such as motion analysis, functional testing (balance tests), or joint imaging. We anticipate cross-pollination with the PhD in Bioengineering, as well as with related programs, including the Masters of Science in Biomedical Imaging (MSBI) and the Masters in Translational Medicine (MTM). Additionally, the formation of the PhD in Rehabilitation Science would lead to several new courses in applied biomechanics and clinical imaging biomechanics that would be available to students in the PhD in Bioengineering program.

Courses offered within Bioengineering, Biomedical Imaging, or Translational Medicine that we anticipate would be of interest to our PhD students: ● Bioengineering: ○ BioE 221 Tissue Mechanobiology ○ BioE 25 Careers in Biotechnology ● Translational Medicine ○ Epi 150.03 Designing Clinical Research ● Biomedical Imaging: ○ BI 201 Principles of MR Imaging ○ BI 202 Physical Principles of CT, PET, and SPECT Imaging ○ BI 240 Musculoskeletal Imaging

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Courses within the PhD in Rehabilitation Science that may be of interest to students in Bioengineering, Biomedical Imaging, or Translational Medicine: ● RS 100 Introduction to Rehabilitation Science ● RS 330 Biomechanics of Human Motion

1.5. Interrelationship of the Program with other University of California Institutions

The current academic programs in the Department work collaboratively with many other departments at UCSF to offer the existing Doctor of Physical Therapy (DPT) and Doctor of Physical Therapy Science (DPTSc) degree programs. The programs are advised by an interdisciplinary, interschool faculty. In addition, students enroll in core coursework offered by a variety of departments, such as pathology, physiology, pharmacy, and biostatistics. Furthermore, given that UCSF does not currently have a strong cadre of faculty and researchers in the areas of exercise physiology and muscle biology, we have connected with UC Irvine for academic expertise from Vince Caiozzo, PhD, who delivers this content for our students.

Currently, UCSF is the only University of California campus with a Department of Physical Therapy and Rehabilitation Science offering an academic program. UC Davis and UC Irvine both have residency programs in Physical Medicine and Rehabilitation for medical trainees. These programs aim to provide trainees with exposure to patients with a wide range of physical impairments and disabilities who may benefit from physiatric medical care. However, these programs are only available to physicians, and not to others interested in the rehabilitation sciences. These two medical residency programs are focused on clinical medicine, whereas the PhD would be a research-based program, informed by laboratory-based translational research and investigative and applied clinical practice.

The Center of Research Translation grant on Osteoarthritis, is a collaboration between UCSF and UC Davis. Richard Souza, PT, PhD is a co-investigator on this large program grant and has regular meetings with faculty from UC Davis, including Nancy Lane and Barton Wise, two rheumatologists and leaders in clinical research in osteoarthritis. These relationships would be leveraged to expose students within the proposed PhD program to research ideas and methodology across the UC campuses. An additional informal collaboration exists with Samuel Ward, PT, PhD from the Department of Radiology at UC San Diego.

Additionally, educational opportunities are available through the annual UCLA Neurotrauma Meeting. This meeting brings together faculty and young investigators, including graduate students, across all UC campuses in a forum that focuses on traumatic brain injury. This meeting provides a unique opportunity for students to present their data as part of the Young Investigator’s Sessions and to network with other researchers. We anticipate that students in the Clinically Informed Neuroscience track may attend this meeting.

Programs at other University of California institutions that may be related to the PhD in Rehabilitation Science include:

12 Table 4: Programs at Other UC Campuses

Institution Programs PhD in Bioengineering UC Berkeley PhD in Epidemiology PhD in Neuroscience PhD in Biomedical Engineering PhD in Epidemiology UC Davis PhD in Neuroscience PhD in Human Development PhD in Biomedical Engineering UC Irvine PhD in Epidemiology PhD in Bioengineering PhD in Biomedical Engineering PhD in Biomedical Physics UC Los Angeles PhD in Epidemiology PhD in Neuroscience PhD in Human Genetics PhD in Bioinformatics PhD in Bioengineering PhD in Biomedical Sciences UC Riverside PhD in Neuroscience PhD in Genetics, Genomics, and Bioinformatics PhD in Bioengineering PhD in Biomedical Sciences UC San Diego PhD in Neurosciences PhD in Public Health PhD in Bioinformatics and Systems Biology UC Santa Barbara PhD in Dynamical Neuroscience

UC Santa Cruz PhD in Biomolecular Engineering & Informatics

Of note, the Neuroscience Programs within the University of California are focused primarily in cellular, molecular and behavioral studies. The UC Davis areas of emphasis are cellular, molecular, developmental, systems, and cognitive neuroscience. UC Los Angeles emphasizes addiction; learning and memory; neural development, degeneration and repair; neurogenetics; neuroimaging/cognitive; and synapses, cells and circuits. UC Riverside’s areas of research are cellular and molecular; development and plasticity; systems neuroscience and behavior; computational neuroscience; cognitive neuroscience; and medical neuroscience. UC Riverside’s program includes a seminar class in neural regeneration and repair, which may have some content overlap with the PhD in Rehabilitation Science. UC San Diego includes three areas of basic neuroscience before specialization: cellular, molecular, developmental; systems; and cognitive, clinical, behavioral. UC Santa Barbara describes research areas in cognitive psychology, neuroimaging, biology, physics, computer science and engineering.

Additionally, San Francisco State University offers a MS degree in Kinesiology, which will offer potential for collaboration with the funded faculty in the department. Kate Hamel, PhD and David Anderson, PhD each have laboratories at SFSU in biomechanics.

1.6. Department or Group that will Administer the Program

The PhD in Rehabilitation Science Program will be housed and administered in the Department of Physical Therapy and Rehabilitation Science. The PhD Program Steering Committee will govern the proposed PhD program. The Steering Committee will be comprised of the following members:

13 • Department Chairs at UCSF and SFSU • PhD Program Director • Faculty Leads for each of the two tracks • One member of the Academic Faculty from within the UCSF Department or a faculty member who holds a primary appointment at SFSU with a WOS appointment at UCSF • One UCSF faculty member outside the Department Duties and responsibilities of this Committee include serving as the Admissions and Curriculum Committees; setting academic standards and establishing requirements for enrollment in the program; making recommendations to the Graduate Dean concerning dismissal of students who fail to fulfill requirements of the program; arranging for the scheduled periodic evaluation of the program; and conducting biennial reviews of program membership.

The Program Director will be a UCSF faculty member and will serve a 3-year renewable term, elected by the Steering Committee, with the following duties and responsibilities: vote as a member of the Steering Committee; act as a liaison between the PhD Program and the Graduate Division, UCSF administration, outside organizations, programs, and students; and oversee funding and resources of the program in consultation with the Department Management Services Officer.

The Faculty Leads for the Musculoskeletal Biomechanics and Clinically Informed Neuroscience tracks will be UCSF faculty members and will be responsible for overseeing the student’s program of study within each track, planning coursework, and communicating staffing needs to the PhD Program Director.

1.7. Plan for Evaluation of the Program

Both formative and summative assessments will be utilized to thoroughly monitor and evaluate the effectiveness of the PhD in Rehabilitation Science program. Students will be required to submit electronic evaluations at the end of each course and upon completion of the program. These evaluations will enable students to identify perceived strengths and weaknesses of the curriculum and reflect on how well the courses meet the overall learning goals of the program. The information gathered from these evaluations will be compiled and analyzed by the Steering Committee and used to improve curriculum and instructional methods and develop additional courses if necessary.

Longitudinal data will also be gathered from alumni to track the professional development of graduates. At two and five years post-graduation, each graduate will be required to submit a CV and to complete a graduate survey, which will assess the impact of the program on their current skills and expertise, as well as how the program affected their ability to find desired employment. This system of tracking student outcomes will contribute to the long-term evaluation of the PhD in Rehabilitation Science program.

In addition to the internal evaluation activities described above, the evaluation of the PhD program will be included as part of the periodic review and evaluation of the Department of Physical Therapy and Rehabilitation Science under the Chair’s Stewardship Review. Additionally, the UCSF Graduate Division and Graduate Council conducts reviews of all UCSF graduate programs without a T-32 grant approximately every eight years. These reviews ensure continued program quality and provide impartial feedback on the program. The review process itself is composed of a self-study, student surveys, an external review, and a post-review follow-up.

14 SECTION 2: PROGRAM

2.1. Admissions Requirements and Undergraduate Preparation

Minimum criteria for admission to the PhD program are set by the UCSF Graduate Division and include a bachelor’s degree and prior grade point average greater than 3.0 or its equivalent. A bachelor’s, master’s or a doctoral degree in physical therapy, neuroscience, exercise physiology, biomedical engineering, or a related rehabilitation science or professional field will be required for admission into the PhD program.

Applicants must have taken the Graduate Record Examination (GRE) within five years of applying, and scores will be considered in the evaluation for admission. While no minimum GRE scores are set by the Graduate Division, applicants will be required to obtain a minimum 50th percentile score on both the Verbal and Quantitative Reasoning sections of the GRE and a 4.5 on the Analytical Writing section.

Admission requirements for students from foreign countries are the same as for domestic students. In addition, international applicants from non-English speaking countries must demonstrate proficiency in English by completing one year of study with a minimum 3.0 GPA at an accredited college or university in the United States, or by obtaining the following minimum scores on the Test of English as a Foreign Language (TOEFL): 550 on paper- based test; 213 on computer-based test; 80 on internet-based test; or 7 on the International English Language Testing System.

Applicants must also submit their CV and a Statement of Purpose (3 to 5 pages) discussing their background, interests, research goals, purpose in applying for graduate study and plans for the future. Applicants must indicate what they hope to gain from being a doctoral student in Rehabilitation Science, how their interests fit with those of the program’s faculty, and any other pertinent information supportive of their application and qualifications.

Finally, applicants must submit three letters of recommendation. Final approval for admission into the PhD program is granted by the Admissions Committee.

The admissions requirements and procedures of the PhD in Rehabilitation Science program are in line with comparable programs at other institutions. Included below is a table of each institution offering a PhD in Rehabilitation Science (or related field) and the admissions requirements.

Table 5: Admissions Requirements at Institutions with PhD in Rehabilitation Science Programs

Required GRE Statement of Letters of Institution Major Degree Required Goals Reference

Yes + CV + health or rehab- related field; Drexel University Bachelors Yes 2 years clinical 3 LORs Masters or DPT preferred experience

DPT or Masters Physical therapy, athletic training, Yes + 2 years Duquesne (must be eligible occupational therapy or related Yes professional 3 LORs University for licensure) field experience Bachelors or Loma Linda Masters (must allied health profession area or Faculty letter of Yes None University hold licensure/ rehab related field support certification) any major that will allow Medical University Bachelors or applicants to focus on functional Yes Yes 3 LORs of South Carolina graduate degree limitations, pathology and impairment, and health services

15 Required GRE Statement of Letters of Institution Major Degree Required Goals Reference Bachelors of physical or occupational therapy, MGH Institute of Masters (must speech-language pathology, Yes Yes 3 LORs Health Professions hold licensure/ rehabilitation nursing, physiatry certification) physical therapy, occupational Yes + 1 lab Northwestern therapy, other health professions, Bachelors Yes research 3 LORs University exercise science, biomechanics, experience engineering, basic sciences University at Buffalo, The State Bachelors field related to rehab science Yes Yes 2 LORs University of New York Must have a MS in Health & Rehab Science; Masters in The Ohio State Masters Occupational Therapy/ Physical Yes Yes + CV 3 LORs University Therapy; Doctor of Physical Therapy; or MS in Dietetics field related to human movement The University of (e.g. physical therapy, exercise Masters North Carolina at science, athletic training, Yes Yes + CV 3 LORs preferred Chapel Hill biomedical engineering, anatomy, etc.) physical therapy, occupational Texas Tech therapy, athletic training, University Health Bachelors Yes Yes + CV 3 LORs kinesiology, biology, medicine, Sciences Center biomedical engineering, etc. occupational therapy, physical University of therapy, engineering, exercise Bachelors or Alabama at science, neuroscience, medicine, Yes None 3 LORs Masters Birmingham nursing, or other health related professions University of Bachelors science, health or engineering Yes Yes 3 LORs Colorado Denver University of Bachelors movement-related field Yes Yes 3 LORs Delaware Yes + prof/clinical University of Florida Bachelors field that can be applied to PhD Yes experience in 3 LORs rehab area physical therapy, occupational University of Iowa Bachelors therapy, engineering, biology, Yes Yes 3 LORs chemistry University of Kansas biological sciences, statistics, Bachelors Yes Yes + CV 3 LORs Medical Center calculus Masters (must communication disorders, University of be eligible for physical therapy, occupational Yes Yes + CV 3 LORs Kentucky licensure) therapy, or athletic training biology, engineering, exercise physiology, exercise science, University of Bachelors kinesiology, medicine, nursing, Yes Yes 3 LORs Maryland occupational therapy, physical therapy University of Medical Sciences Masters Health related field No Yes 2 LORs Arizona University of Bachelors field related to rehab science Yes Yes + CV 3 LORs Minnesota

16 Required GRE Statement of Letters of Institution Major Degree Required Goals Reference University of Yes + CV + Writing Masters Rehab related field Yes 3-5 LORs Pittsburgh sample University of science major; research-based Bachelors Yes Yes + CV 3 LORs Southern California Masters recommended rehabilitation medicine/ science, physical and occupational therapy, nursing, neuroscience, Yes + clinical and University of Texas Bachelors exercise sciences, kinesiology, Yes research 3 LORs Medical Branch bioengineering, human factor experience engineering/design, and rehabilitation/clinical psychology occupational therapy, physical therapy, speech/ language University of pathology, rehab counseling, Bachelors Yes Yes + CV 3 LORs Washington prosthetics & orthotics, medicine, nursing, engineering, or other fields related to rehab science Virginia Common- Masters movement science related field Yes Yes 3 LORs wealth University movement science related Washington discipline: physical therapy, Yes + CV + Writing University in St. Bachelors exercise physiology, kinesiology, Yes 3 LORs sample Louis occupational therapy, biomechanical engineering

2.2. Foreign Language Competence

A Test of English as a Foreign Language (TOEFL) for those who do not speak English as a primary language will be required (see Section 2.1 above).

2.3. Program of Study

Two focused areas of specialization will be established that represent the expertise of our Department as well as the UCSF community as a whole. They include: Musculoskeletal Biomechanics and Clinically Informed Neuroscience. These areas of specialization are supported by established research infrastructure, including basic science laboratories on the Parnassus and SFGH campuses, movement analysis labs on the Mission Bay campus, imaging facilities, clinical physical therapy and health and wellness facilities, and the Neurobehavioral Core for Rehabilitation Research (see Appendix B for equipment available for research purposes in the Physical Therapy Outpatient Practice). The latter is a Core facility, supported by the Department of Physical Therapy and Rehabilitation Science that is available to the research community to study behavior of mouse models of injuries/diseases and to address activity-based restoration of function. In addition, SFSU has a movement analysis lab and a lab dedicated to clinical research.

These two areas of specialization include academic coursework offered at UCSF, and represent research interests of current faculty within the Department of Physical Therapy and Rehabilitation Science. Specifically, the unit requirements and required/elective courses in each area of specialization would be as follows.

Specific Field of Emphasis: Rehabilitation Science

Plan: Doctor B

Unit Requirements: ● Total core units: 12

17 ● Total rotation units: 6-9 ● Total elective units: 9-12 ● Total research units: 108 ● Grand total units: 135-141

Required and Recommended Courses:

First year: Focus on core courses in Rehabilitation Science, Statistics, Research Ethics, and Basic Sciences

The primary focus of the first two years of the PhD program will be to expose the student to the basic core courses in Rehabilitation Science and provide opportunity for students to experience and ultimately select a laboratory and Principal Investigator with whom to complete their dissertation. Courses taken in the first year include: RS 100 Introduction to Rehabilitation Science, BMS 214 Ethics and the Responsible Conduct of Research, EPI 150.03/202 Designing Clinical Research, biostatistics courses, and other basic science courses needed, based upon the student’s needs and interests (Anatomy, Physiology, Neuroscience, Statics and Dynamics, etc.). The remainder of the first year of study will be filled with Research Lab rotations (10-20 hours/week), the teaching assistantship or practicum, and the Doctoral Colloquium.

Also during their first year, with the guidance of the Steering Committee, students will each form a Graduate Committee of at least three faculty members comprised of two faculty within the PhD Program, and one member from an external department whose expertise is related to the candidate’s research interest (this may be too early for a dissertation topic). The Chair of the Committee will be a member of the PhD Program faculty and may be the student’s primary research mentor. One faculty member should be from the chosen sub-field and presumed dissertation topic of the student. The Graduate Committee will review the student’s plan of study, actively advise him/her on appropriate choices, and make decisions as to acceptable progress. Guidelines for typical and acceptable courses of study will be used, but exceptions may be liberally considered by the Graduate Committee depending on the needs of the student. The Graduate Committees will be overseen by the Steering Committee to ensure consistency in the expectations for training and a level of achieved competence by all students.

Students will be required to complete three quarters of lab rotations (3 units each), similar to the lab rotation requirement in other established PhD Programs at UCSF (e.g. Biomedical Sciences, Biological and Medical Informatics and Pharmaceutical Sciences and Pharmacogenomics). The objective of these rotations is for the student to have the opportunity to:

1. Apply concepts taught in formal classes 2. Learn practical aspects of conducting research, including how to work within a multidisciplinary team 3. Acquire exposure to areas of research other than the student’s primary area 4. Launch projects with potential for developing into qualifying examination or dissertation research topic 5. Decide on a primary research mentor, if not already identified

Three lab rotations will be required over three quarters before advancing to Candidacy status. A plan for which research teams to rotate with should be part of the Year 1 Plan of Study approved by the Graduate Committee. The subject matter for each rotation, however, is not prescribed by the PhD Program and would be determined by the needs of the research team and the student.

In the lab rotations, PhD students will participate in active research teams at UCSF or SFSU, or affiliated institutions. The PI and the student will set a plan for the lab rotation, including expectations. The PI is responsible for monitoring participation and student learning in the lab rotation.

Second year: Begin to focus on specific area of research in either the Musculoskeletal Biomechanics or Clinically Informed Neuroscience track

Within the first two years of study, the student, with the assistance of his/her Graduate Committee, will be

18 expected to choose a research emphasis, concordant with the expected dissertation topic, that will guide topic- specific and experiential study. Formulation of the topic will be the responsibility of the student with the oversight and advice of his/her Graduate Committee and primary research mentor.

By the end of the second year in the PhD program, the student is expected to have selected a research focus and a primary research mentor. The goal of the second year is to allow the student to finalize his/her dissertation focus and obtain the necessary knowledge and skills to successfully execute the dissertation. Coursework to be taken during this time includes electives within the selected domain, such as RS 330 Biomechanics of Human Motion or RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan, additional courses in biostatistics, and continuing with the Doctoral Colloquium. It is expected that the student will have at least 20 hours per week for research experiences, including pilot studies for the dissertation proposal, as appropriate.

The primary research mentor will be the principal advisor and supporter of the graduate student. The primary research mentor must have the means to provide financial support from existing research grants for tuition and stipend for years three and beyond.

Figure 1: Committee Structure

2.4. Field Examination

None.

2.5. Qualifying Examination

In the PhD program, doctoral students must take and pass a combined written and oral Qualifying Examination. The Qualifying Examination provides evidence the student is able to:

● Critically read, understand, and evaluate current literature in the discipline ● Integrate and synthesize ideas within the field ● Demonstrate comprehensive knowledge of the literature in the field ● Critically evaluate empirical evidence ● Demonstrate a comprehensive understanding of techniques critical to scholarship in the field ● Communicate clearly and effectively to specialist and non‐specialist audiences

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After completing all required coursework in the first two years, including at least five quarters, a student may apply to the Graduate Division to take the qualifying examination with the written approval of the Chair of his or her Graduate Committee. The examination is offered at the convenience of the student and his or her Graduate Committee and consists of a detailed six-page National Institutes of Health (NIH) style grant proposal to answer a rehabilitation science research question in a field related to his/her primary research area (sections of the NIH style grant proposal will include: 1) Introduction; 2) Specific aims; and 3) Research strategy, including the significance, innovation, and approach to be utilized). Students submit their proposal to the Qualifying Examination Committee at least 30 days prior to the date of their scheduled qualifying examination. The student must meet individually with each member of the Qualifying Examination Committee at least once prior to scheduling the qualifying examination. The Qualifying Examination Committee is comprised of a minimum of four faculty members, three of whom must be UCSF Academic Senate faculty members in the PhD program. Faculty from SFSU or other academic institutions as well as non-Academic Senate UCSF faculty can, with written permission from the Graduate Division, serve on the Qualifying Examination Committee. The faculty member designated the chair of the Qualifying Examination Committee must be a UCSF Academic Senate member who is a faculty member in the PhD program. The chair of the Qualifying Examination Committee cannot be the same individual who chairs the student’s Graduate Committee.

The oral portion of the qualifying examination lasts up to three hours and is closed to the general public, with the exception of the primary research mentor, who is only an observer. The student will be allowed to make a 10-15 minute presentation on his/her research plan with a dry erase board made available for a “chalk talk”. Questions for the oral examination will typically be based on the presentation, but can include materials covered from any required class in the curriculum, as well as anything pertaining to the student’s area of specialization. The purpose of the oral examination is to determine the student’s mastery of content within the rehabilitation science program. Upon finishing their course of study and taking the examination, students should be able to apply reasoning related to rehabilitation science to their chosen substantive areas and resolve methodological problems. The examination will cover the breadth and depth of a student’s knowledge in his/her area of specialization within the field of rehabilitation science.

In accordance with the UCSF Graduate Division guidelines, at least one meeting of the whole committee must be held to discuss the results of the examination. The committee may grade the examination either “Pass” (or “Contingent Pass”, pending response to committee concerns on the proposal) or “Fail”. In line with UCSF Graduate Division guidelines, if a student fails the examination, the committee must make a recommendation for or against a second examination. The committee must be the same as for the original exam. If the student failed in all areas, the re-examination must be on all subjects involved. A partial failure, in which the student passes some fields, but not others, also counts as a first examination. However, re-examination after partial failure may be restricted to those areas in which the original performance was unsatisfactory. The minimum time between examinations is three months. Students who fail the oral examination a second time will be dismissed from the PhD program.

2.6. Dissertation

Each doctoral student conducts research under the supervision of a primary research mentor and a Dissertation Committee. The student and primary research mentor recommend a Dissertation Committee, which is formally appointed by the Graduate Division. Once a student successfully passes the qualifying examination, the student’s Graduate Committee will disband, and a Dissertation Committee will be formed. This Committee will be composed of three faculty knowledgeable in the field related to the student’s research. The Dissertation Committee is responsible for overseeing the research conducted by the student, and offering an outside, unbiased assessment to the primary research mentor. The chair of the Dissertation Committee must be a UCSF Academic Senate faculty member and member of the PhD program. The chair of the Dissertation Committee may have been a member, but not the chair, of the student’s Qualifying Examination Committee, and may not be the student’s primary research mentor. A Dissertation Committee must have a minimum of three faculty members in the PhD program. Faculty from SFSU or other universities may be appointed to serve on the Dissertation Committee. All research involving

20 human subjects, including analyses of previously collected data, must have been approved (or declared exempt) in writing by the UCSF Committee for Human Research in order to be included in a dissertation, regardless of which or how many other such committees elsewhere have previously approved the research. Additionally, research using animals must have been approved in writing by the UCSF Institutional Care and Use Committee in order to be included in the dissertation.

The goal for the dissertation is to provide the student independent-investigator involvement, including idea conception, study design, methodological structure, acquisition, processing, and interpretation, with mentoring and oversight from the Dissertation Committee. It is anticipated that the student’s dissertation will include two or three separate projects addressing a single focused dissertation objective with sufficient depth and breadth to contribute to the body of literature in the field. The expectation is that this work will generate at least three independent manuscripts, to be published in peer-reviewed journals.

2.7. Final Examination

Dissertation Defense A closed Defense of the Dissertation will be required for all students. Each student will have 45 minutes to orally present his/her dissertation written project, including the background, methods, results, discussion, and conclusions, to the Dissertation Committee and primary research mentor. This presentation and subsequent questioning will represent the acceptance or refusal by the Committee of the student’s body of work throughout the dissertation process. After the formal presentation by the student, the Committee will be allowed to ask questions, propose changes to the written dissertation, and/or request additional investigations, which must be within the scope of the approved research proposal. At the completion of the questioning, the student will be asked to leave the room while the Committee discusses the student’s performance and ultimately decides if the body of work satisfactorily meets the requirements of the Doctor of Philosophy in Rehabilitation Science. Once a decision has been made, the student will be informed of the outcome. Options include: Pass without modification to written dissertation; Pass With Modifications to the written dissertation; and Failure of Initial Attempt with an option to revise the dissertation and re-present.

Final Presentation After the Dissertation Committee has approved the completed dissertation, a final presentation will be required for all students, prior to graduation. The presentation will be open to the local scientific community, general public, and family and friends. Announcements will be made to the appropriate UCSF, SFSU, and outside communities regarding the dissertation presentation. After the completion of the presentation, the student will be required to field questions from the general audience.

2.8. Explanation of Special Requirements

None.

2.9. Relationship of Master’s and Doctor’s Programs

As detailed above under the Admissions section, admission to the PhD program will require that an applicant has a baccalaureate degree, and a master’s degree will be optional, but preferred. If an applicant is accepted without a master’s degree, the applicant will take a required set of preparatory courses as a first step in his/her training.

2.10. Special Preparation for Careers in Teaching

In the PhD program, all doctoral students are expected to teach, serving as a Teaching Assistant for a course at least one quarter or semester in length before the Qualifying Examination. This teaching experience requires students to organize their own knowledge in the field so that they can effectively present and explain the material to others. It also serves as an important foundation for future academic positions.

21 In addition, students in the program may receive additional teaching training by enrolling in a teaching training through the Haile T. Debas Academy of Medical Educators and the Office of Medical Education, which offers courses and workshops for faculty and pre-doctoral fellows in writing a course syllabus, assessment instruments, and innovative teaching techniques. PhD students may also take advantage of the Teaching Improvement Program/Teaching Observation Program offered through the Academy.

2.11. Sample Program

Below is an initial proposed curriculum. There are two general tracks available to students. All students will take the following courses (new courses indicated with an asterisk):

“C” - core course “LR” - lab rotation “D” - research/dissertation “E” – elective “T” - teaching

YEAR 1

Fall Quarter ● C - *RS 100 Introduction to Rehabilitation Science (2 units) ● C - *RS 150 Gross and Regional Anatomy (1 unit) ● D - RS 300 Doctoral Colloquium (1 unit) ● LR - *RS 200 Research Lab Rotation (3 units) or at SFSU PT 996 Directed Studies (3 semester units) Winter Quarter ● C - Biostat 187 Introduction to Statistical Theory and Practice (5 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● LR - *RS 200 Research Lab Rotation (3 units) or at SFSU PT 996 Directed Studies (3 semester units) Spring Quarter ● C - BMS 214 Ethics and the Responsible Conduct of Research (2 units) ● C - EPI 150.03/202 Designing Clinical Research (2 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● LR/E - *RS 200 Research Lab Rotation or at SFSU PT 996 Directed Studies (3 semester units) Summer Quarter ● T - *RS 310 Teaching Practicum (3 units) or at SFSU PT 960 Teaching Practicum (3 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● D - *RS 350 Research (5 units) or at SFSU PT 997 Research (2 semester units)

YEAR 2

Fall Quarter ● E - Elective (3 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● D - *RS 350 Research (5 units) or at SFSU PT 997 Research (2 semester units) Winter Quarter ● E - Elective (3 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● D - *RS 350 Research (5 units) or at SFSU PT 997 Research (2 semester units) Spring Quarter ● E - Elective (3 units) ● D - RS 300 Doctoral Colloquium (1 unit) ● D - *RS 350 Research (5 units) or at SFSU PT 997 Research (2 semester units) ● Qualifying Examination Summer Quarter ● D - RS 300 Doctoral Colloquium (1 unit) ● D - *RS 350 Research (8 units) or at SFSU PT 997 Research (2 semester units)

22 YEAR 3 ● D - All quarters will be RS 350 Research (8 units) and RS 300 Doctoral Colloquium (1 unit)

Total core units: 12 quarter units (year 1)

Total lab rotation units: 6-9 quarter units (year 1) Rotations in labs; students must enroll in rotations for at least two quarters in the fall, winter, and/or spring of the first year.

Total elective units: 9-12 quarter units (year 2)

Total research units (research + quarterly 1-unit doctoral seminar): 108 quarter units (years 1 through 4) 36 quarter units (years 1 and 2), and 72 quarter units (years 3 and 4)

Grand total units: 135 - 141 quarter units

Students enroll in elective coursework, based on consultation with their Graduate Committee, in the second year of the program. Given the interdisciplinary nature of the program and the UCSF academic culture, included below is only a short list of the available opportunities for students:

Required Coursework: ● *RS 100 Introduction to Rehabilitation Science (2 units) ● *RS 150 Gross and Regional Anatomy (1 unit) ● Biostat 187 Introduction to Statistical Theory and Practice or equivalent (5 units) ● BMS 214 Ethics and the Responsible Conduct of Research (2 units) ● EPI 150.03/202 Designing Clinical Research (2 units)

Elective Coursework of Interest to All Students: ● BioE 25 Careers in Biotechnology (1 unit) ● BMS 225A Human Disease: Technologies and Biomedical Applications (1.5 units) ● BMS 225B Tissue and Organ Biology (3 units) ● BMS 255 Basic Genetics and Genomics (4 units) ● BMS 260 Cell Biology (4 units) ● MICRO 204 Molecular and Cellular Immunology (3 units) ● PT 251 Research Design (3.5 units) ● TICR Summer Clinical Research Workshop (required to take 2+ courses in series) ○ EPI 150.03 Designing Clinical Research (2 units) ○ Biostat 212 Introduction to Statistical Computing in Clinical Research (1 unit) ○ EPI 218 Database Management Systems for Clinical Research (1 unit) ○ EPI 227 Building a Career in Clinical Research (0.5 unit)

Elective Coursework within the Musculoskeletal Biomechanics in Rehabilitation Science emphasis: ● BI 201 Principles of MR Imaging (4 units) ● BI 202 Physical Principles of CT, PET, and SPECT Imaging (4 units) ● BI 240 Musculoskeletal Imaging (3 units) ● BioE 221 Tissue Mechanobiology (2.5-3 units) ● *RS 130 Basics in Musculoskeletal Imaging (3 units) ● *RS 330 Biomechanics of Human Motion (2 units) ● *RS 331 Running Biomechanics and Overuse Injuries - Journal Club (2 units)

Elective Coursework within the Clinically Informed Neuroscience emphasis: ● ANA 207 Neuroscience (5 units) ● N 294B Medical Genetics for Nursing (3 units)

23 ● NS 219 Topics in Basic or Translational Neuroscience (topics include: Epigenetics in the Brain; Brain Injury; Molecular Genetic Tools; Basal Ganglia; Neuroinflammation) (3 units) ● NS 225 Neurobiology of Disease (3 units) ● NS 245 Behavioral Neuroscience (3 units) ● PT 420 Mentored Research (2.5 units) ● *RS 110 Principles and Applications of Evidence-based Practice (3 units) and at SFSU PT 910 Evidence Based Practice (4 semester units) ● *RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan (2 units) ● RS 400 Topics in Clinically Informed Neuroscience (e.g. Challenges in Translation of Science to the Clinic) (2 units)

Many other courses are offered as part of other existing graduate programs at UCSF, SFSU, and at other institutions and UC campuses through the Intercampus Exchange Program.

2.12. Normative Time from Matriculation to Degree

The time needed to complete the PhD in Rehabilitation Science will vary depending on the student’s training and experience prior to enrolling in the PhD program and the time it takes to complete the dissertation research. Students who have completed undergraduate level training require at least two years to complete their coursework and pass their qualifying examination, followed by an additional two to three years to complete their research and file the dissertation. Those who have completed Masters level training may progress more quickly through the coursework. Thus, the mean time to completion of a PhD in Rehabilitation Science for students entering with a Bachelor’s degree is expected to be approximately five years. To facilitate timely progress in the program, all students will be required to complete annual progress reports and to discuss them with their adviser and Graduate Committee or Dissertation Committee.

24 SECTION 3: PROJECTED NEED

3.1. Student Demand for the Program

We propose an enrollment of two new students every other year for six years, until 12 students are enrolled. We expect no difficulty in admitting this number of high quality applicants, as most top-rated programs in rehabilitation science turn away strong applicants. The following is a table of peer institutions, which includes the number of applications received each year and the number of students admitted. It is clear from this information that there are many more students interested in PhD programs in Rehabilitation Science than there are available openings.

Table 6: Student Demand at Peer Institutions

# Students Employment Faculty Institution # Apps Top 5 Areas of Training Funding Sources Admitted of Graduates Openings Duquesne 5 per 100% 1) Orthopedics Graduate assistant Not at the 0-2 per year University year academia 2) Clinical Biomechanics funding from the dept present time 1) Pediatrics No training grants; 67% academia 2) Biomechanics students are on grants 2 openings in PT: Ohio State 6 per 3 per year 33% clinical 3) Neuro of their mentors; some one in ortho and University year research 4) Human Factors receive University one in neuro 5) Diet & Nutrition fellowships 1) Applied Anatomy and Biomechanics 2) Exercise Physiology Yes, 2-3 80% academia 40% on TA-ship funded 3) Tissue/Molecular openings University of 30-40 15% industry by department; 2-4 per year Biomechanics appropriate for Delaware per year 5% non- remainder are primarily 4) Motor Control & PhD in Rehab research on faculty grants Behavior Science 5) Rehabilitation Engineering 1) Muscle adaptation Mentor’s grants, TA 2) Musculoskeletal positions, funds from Injuries country of origin, Yes, openings in University of 12 per 95% into 3) Outcomes of 2-3 per year university fellowships, cardiopulmonary Minnesota year academia Therapeutic Intervention PT Foundation, NIH and rehab 4) Postural Control predoc awards, AHA 5) Stroke Recovery and predoc awards Neuroplasticity 1) Biomechanics 2) Computational Neurorehabilitation University of 95% into TA and RA positions. RA 30 per 3) Exercise Physiology Southern 6 per year academia positions come from None year 4) Motor Learning and California grants Motor Control 5) Neuroplasticity and Imaging T32 (supports 3 1) Translational students per year), mainly into Physiology departmental funds (2 anticipate hiring Washington academia (90- 2) Movement and students supported), 15-20 3-5 tenure University at 2-3 per year 95%) and some Movement-related F31s, TL1 program (3 per year faculty in the St. Louis go to industry Dysfunction students funded), R01s next five years (5-10%) 3) Musculoskeletal or other grants to the Analysis PIs of the labs the students are working in

25 On the demand side, the need for medical scientists is rapidly increasing as the general population begins to age. The Bureau of Labor Statistics has documented in the Occupational Outlook Handbook that the number of Medical Scientist positions is expected to increase by 36% (from 100,000 to 136,400 positions) between 2010 and 2020, a rate much higher than the national average for all occupations6. Additionally, the growth of Postsecondary Teacher positions is projected to increase by 17% as enrollments at postsecondary institutions continue to rise7.

According to the aggregate program data for APTA-accredited Physical Therapy programs, in 2011-12, there were 132 current vacancies in allocated faculty positions, and 83 projected vacancies in allocated faculty positions8. In 2012-13, there were 153 current vacancies in allocated faculty positions, and 105 projected vacancies in allocated faculty positions. The average age of core faculty in APTA-accredited Physical Therapy programs is between 50 and 60 years of age, and 71% of all core faculty are between 45 and 65 years of age. Additionally, in 2012-13, 88% of core faculty in APTA-accredited Physical Therapy programs were self-identified as White or Caucasian. These statistics support the growing need for the next generation of a diverse pool of qualified academic researchers and educators who can contribute to the body of research and educate future physical therapists who represent the diversity of the communities they will serve.

3.2. Opportunities for Placement of Graduates

Graduates of the PhD Program in Rehabilitation Science will be prepared as researchers, educators, and leaders in the field of rehabilitation science. Our interdisciplinary educational approach prepares students to conduct collaborative and translational research by integrating knowledge from multiple perspectives ranging from the cellular to the systems level to solve complex problems of physical disablement. Upon graduation, students will pursue academic careers in research and higher education. These individuals will be prepared to address research, education, service delivery, and policy challenges requiring an interdisciplinary perspective. Openings in academia for faculty positions are numerous in this field, and range in positions in Physical Therapy, Gerontology, Oncology, Physiotherapy, Health Sciences, Rehabilitation, and Movement Science departments.

Exceptional students with substantial experience prior to completion of the PhD may be prepared to begin faculty positions immediately upon completion of their dissertation. However, in order to be successful in rigorous academic settings, a postdoctoral fellowship will be recommended to graduates after completion of the PhD. During a postdoctoral fellowship, graduates will complete the process of publishing their dissertation research and work as full-time researchers with a faculty mentor (typically not the primary research mentor). The objective of the postdoctoral fellowship is to provide the graduate time to develop a line of independent investigation to launch their career so that upon accepting a faculty position, the graduate’s area of scholarship is defined and the individual is well on his/her way to securing substantial extramural funding to launch an original research program. Graduates will have developed extensive skills as teachers while in the program, also preparing them to succeed in this demanding aspect of the academic career.

3.3. Importance to the Discipline

The PhD Program in Rehabilitation Science will be housed within UCSF, which will allow it to become a premier opportunity for researchers interested in the field. UCSF is first among public institutions and ranked second among all institutions nationwide in research support from the National Institutes of Health (NIH) for fiscal year 2011. UCSF is also one of the leading institutional recipients of science-based stimulus funds under the American Recovery and Reinvestment Act. Acclaimed faculty conducting investigations involving humans, as well as animal

6 Medical scientists : Occupational outlook handbook : U.S. bureau of labor statistics http://www.bls.gov/ooh/life-physical-and- social-science/medical-scientists.htm. Accessed 12/1/2013, 2013. 7 Postsecondary teachers : Occupational outlook handbook : U.S. bureau of labor statistics http://www.bls.gov/ooh/education- training-and-library/postsecondary-teachers.htm. Accessed 12/1/2013, 2013. 8 Commission on Accreditation in Physical Therapy Education: 2012-13 Fact Sheet for Physical Therapist Education Programs. http://www.capteonline.org/uploadedFiles/CAPTEorg/About_CAPTE/Resources/Aggregate_Program_Data/AggregateProgramD ata_PTPrograms.pdf. Accessed 12/1/13, 2013.

26 models, are discovering new solutions for preventing and treating a wide array of diseases, including cardiovascular disease, neurological disorders, cancer, diabetes, genetic disorders, immunological and infectious disease, and reproductive and developmental disorders. UCSF has started multiple groups within the University specifically related to the field of Rehabilitation Science, including the Institute for Health and Aging, the Cardiovascular Research Institute, and the Institute for Neurodegenerative Diseases.

Additionally, the Physical Therapy profession has developed a set of research goals that the proposed PhD program will be able to directly address. The proposed PhD program will initially focus on a subset of the profession’s priorities, including9:

• Basic Science Research o Examine how genetic, anatomical, biomechanical, physiological, or environmental factors contribute to excessive stress, injury, or abnormal development of body tissues and systems, and measure the effects of physical therapy interventions on structural properties and physiological responses of healthy, injured, or diseased tissues. o Examine skill acquisition and motor development in individuals with movement disorders. o Examine the relationships between biomarkers and impairments in body structure and function, limitations in activity, and restrictions in participation. o Define the role for physical therapy in the maturation and modeling of genetically engineered tissues. o Determine the mechanisms by which existing and novel physical therapy interventions modify disease and age-related or injury-induced changes in normal cellular structure and function using appropriate human and animal models. • Clinical Research o Examine the relationships among levels of functioning and disability, health conditions, and contextual factors for conditions commonly managed by physical therapists, and develop and evaluate models of health and disability to guide the investigation, prevention, and treatment of these health conditions. o Evaluate or develop effective physical therapy interventions and technologies to address movement disorders and chronic disease, and to prevent or reduce the risk of disability and optimize health outcomes. o Develop and evaluate effective patient/client classification methods and decision support tools, effectiveness and efficacy of physical therapy interventions, criteria for progression in levels of care, contextual and adherence factors that affect prognosis and predictors of recovery, in order to optimize clinical decision making and patient/client outcomes. • Education/Professional Development o Develop and evaluate the most effective methods for facilitating physical therapist acquisition and use of available information resources for evidence-based practice. o Evaluate the skills needed by practitioners to provide optimal patient/client care, patient/client advocacy, and cost-effective care. • Epidemiology o Examine the incidence, prevalence, and natural course of health conditions and impairments of body functions and structure, activity limitations, and participation restrictions associated with health conditions commonly managed by physical therapists. o Investigate the effects of contextual factors on the effectiveness of interventions provided by physical therapists. • Health Services Research/Policy o Evaluate the incorporation of patient/client values and expectations in decision-making, and the effect of physical therapy interventions and service delivery models on economic and patient/client outcomes and consumer choice.

9 Goldstein MS, Scalzitti DA, Craik RL, et al. The revised research agenda for physical therapy. Phys Ther. 2011;91(2):165-174. http://ptjournal.apta.org/content/91/2/165.full. Accessed 12/1/2013, 2013.

27 o Develop innovative medical informatics applications for physical therapy and assess their impact on clinical decision making and patient/client outcomes. • Measurement Development and Validation o Develop new measurement tools and evidence to guide selection and interpretation of measures to enhance clinical decision making for specific conditions and populations. o Determine how contemporary technology (e.g. ultrasound, gene array, magnetic resonance) can be used to measure the effects of injury/disease and physical therapy intervention on body structure and function.

3.4. Ways in which the Program will Meet the Needs of Society

As the population continues to age, the development of programs in the interdisciplinary field of rehabilitation will be essential to ensure new research is produced to support the healthcare needs of society. The professions of physical and occupational therapy are expected to expand in upcoming decades with longer projected age spans of the general population and the increased prevalence of obesity. With this increased demand, rehabilitation specialists will be needed to provide effective and efficient care. However, the current evidence behind the practice of physical and occupational therapy is lacking in nearly all areas of clinical practice. Rehabilitation scientists with advanced research training are in critical demand to begin to evaluate these issues, to evaluate the effectiveness of current injury prevention and rehabilitation science, and to develop new potential injury prevention and rehabilitation strategies.

The program has established two areas of specialization within the field of rehabilitation science, given the healthcare needs of society. The Clinically Informed Neuroscience specialization was developed based on the increased prevalence of neurodegenerative diseases (e.g. Multiple Sclerosis, Parkinson’s Disease), stroke and traumatic brain injuries (TBI) in the US population. According to the CDC, stroke kills almost 130,000 Americans each year—1 in every 19 deaths. Every year, more than 795,000 people in the United States have a stroke; about 610,000 of these are first or new strokes and one in four are recurrent strokes. Currently, stroke costs the United States an estimated $38.6 billion each year, which includes the cost of health care services, medications, and missed days of work. Stroke is a leading cause of serious long-term disability10. Additionally, an estimated 1.7 million people sustain a traumatic brain injury (TBI) annually. Of them, 52,000 die, 275,000 are hospitalized, and 1.365 million—nearly 80%—are treated and released from an emergency department. Direct medical costs and indirect costs of TBI, such as lost productivity, totaled an estimated $60 billion in the United States in 200011.

The Musculoskeletal Biomechanics specialization was established to address the increasing prevalence of arthritis in the aging and obese population. According to the CDC, arthritis is the most common cause of disability in the United States, limiting the activities of nearly 21 million adults. Scientific studies have shown that physical activity can reduce pain and improve function, mood, and quality of life for adults with arthritis. Physical activity can also help manage other chronic conditions that are common among adults with arthritis, such as diabetes, heart disease, and obesity. Currently, 50 million people are affected with arthritis and it is estimated that one in two people will get symptomatic knee osteoarthritis in their lifetime12. Additionally, more than 36% of adults in the US are currently obese, and medical costs associated with obesity were estimated at $147 billion in 200813.

3.5. Relationship of the Program to Research and/or Professional Interests of Faculty

The formation of a PhD Program in Rehabilitation Science has been part of the Department’s strategic plan since 2008. The multiple research programs and interests of the faculty members would benefit greatly from the

10 Stroke facts | cdc.gov http://www.cdc.gov/stroke/facts.htm. Accessed 12/1/2013, 2013. 11 CDC - statistics - traumatic brain injury - injury center http://www.cdc.gov/TraumaticBrainInjury/statistics.html. Accessed 12/1/2013, 2013. 12 CDC - arthritis - data and statistics http://www.cdc.gov/arthritis/data_statistics.htm. Accessed 12/1/13, 2013. 13 Obesity and overweight for professionals: Data and statistics - DNPAO - CDC http://www.cdc.gov/obesity/data/index.html. Accessed 12/1/2013, 2013.

28 constant presence of PhD-level graduate students within the department. Existing research programs in basic neuroscience, radiology, orthopedic surgery, and biomechanics, along with a faculty representation in the Musculoskeletal Quantitative Imaging Research (MQIR) group in the Department of Radiology and Biomedical Imaging, the mini courses offered through the Neuroscience community, and a variety of grand round options, all provide opportunities for graduate students to develop projects for their dissertations and other research and educational interests. Department faculty currently have access to other UCSF programs in Bioengineering, Neuroscience, and the Biomedical Sciences, but none of those areas has a focus on rehabilitation.

The Department sees the top priority of the PhD program to find a strong match between the current research projects of program faculty and incoming PhD student interest. Given this priority, the Department intends to start the program by focusing on a few key areas of rehabilitation science from ongoing research lines of the Department faculty.

3.6. Program Differentiation

The proposed PhD in Rehabilitation Science has two primary characteristics that differentiate it from other existing programs within the UC system or in the State of California.

First, since the program will be based within a school of medicine, as compared to a school of public health, the orientation toward and opportunities for training and research in clinical problem solving and translational sciences as well as links to excellent basic science departments are very strong. UCSF is world famous for the outstanding quality of its basic sciences and opportunities abound for lab rotations and other training in basic science laboratories for interested students. Likewise, the campus’ excellent professional schools, all rated within the top three in NIH funding nationwide, provide opportunities to learn about the application of rehabilitation science in the clinical setting. A comparison of T-32 grant activity at UCSF and comparable institutions demonstrates the high level of grant activity at UCSF as compared to other institutions offering a similar degree program.

Table 7: Comparison of T-32 Grant Activity in 2012 and 2013

Institution University Training Grants Rehabilitation Training Grants 2012: $0 (n=0) 2012: $0 Drexel University 2013: $0 (n=0) 2013: $0 2012: $0 (n=0) 2012: $0 Duquesne University 2013: $0 (n=0) 2013: $0 2012: $0 (n=0) 2012: $0 Loma Linda University 2013: $0 (n=0) 2013: $0 2012: $3,523,823 (n=14) 2012: $0 Medical University of South Carolina 2013: $3,603,611 (n=13) 2013: $0 2012: $5,764,405 (n=21) 2012: $0 MGH Institute of Health Professions 2013: $6,589,139 (n=19) 2013: $0 2012: $8,054,128 (n=32) 2012: $708,233 Northwestern University 2013: $7,325,680 (n=30) 2013: $626,729 2012: $2,973,598 (n=13) 2012: $0 The Ohio State University 2013: $3,268,764 (n=16) 2013: $0 2012: $15,722,227 (n=57) 2012: $318,397 The University of North Carolina at Chapel Hill 2013: $14,818,902 (n=50) 2013: $432,763 2012: $0 (n=0) 2012: $0 Texas Tech University Health Sciences Center 2013: $0 (n=0) 2013: $0 2012: $4,560,500 (n=22) 2012: $195,471 University of Alabama at Birmingham 2013: $5,275,467 (n=21) 2013: $262,501 2012: $607,953 (n=4) 2012: $0 University at Buffalo, The State University of New York 2013: $805,318 (n=5) 2013: $0

29 Institution University Training Grants Rehabilitation Training Grants 2012: $18,004,693 (n=57) 2012: N/A University of California, San Francisco 2013: $18,350,321 (n=55) 2013: N/A 2012: $6,919,474 (n=26) 2012: $0 University of Colorado Denver 2013: $7,560,108 (n=31) 2013: $0 2012: $346,526 (n=2) 2012: $67,866 University of Delaware 2013: $394,142 (n=2) 2013: $155,291 2012: $2,464,065 (n=13) 2012: $205,731 University of Florida 2013: $1,948,748 (n=11) 2013: $0 2012: $7,195,268 (n=25) 2012: $0 University of Iowa 2013: $7,263,834 (n=26) 2013: $0 2012: $1,604,541 (n=4) 2012: $214,931 University of Kansas Medical Center 2013: $1,530,652 (n=8) 2013: $174,859 2012: $2,185,694 (n=11) 2012: $0 University of Kentucky 2013: $1,744,988 (n=10) 2013: $0 2012: $3,841,749 (n=18) 2012: $0 University of Maryland 2013: $3,562,960 (n=17) 2013: $0 2012: $1,927,366 (n=13) 2012: $0 University of Medical Sciences Arizona 2013: $1,182,950 (n=8) 2013: $0 2012: $9,868,557 (n=34) 2012: $256,351 University of Minnesota 2013: $9,903,968 (n=31) 2013: $274,442 2012: $12,620,803 (n=57) 2012: $28,157 University of Pittsburgh 2013: $13,516,467 (n=58) 2013: $28,157 2012: $3,058,674 (n=10) 2012: $0 University of Southern California 2013: $2,104,168 (n=8) 2013: $0 2012: $1,943,937 (n=9) 2012: $0 University of Texas Medical Branch 2013: $2,082,273 (n=9) 2013: $0 2012: $21,983,127 (n=61) 2012: $0 University of Washington 2013: $20,272,808 (n=56) 2013: $0 2012: $1,801,414 (n=6) 2012: $0 Virginia Commonwealth University 2013: $1,384,248 (n=6) 2013: $0 2012: $16,949,967 (n=50) 2012: $153,637 Washington University at St. Louis 2013: $16,764,449 (n=50) 2013: $143,012

Second, the campus is home to a very strong social science tradition and opportunities exist in behavioral and social epidemiology and community participatory research. Therefore, this multidisciplinary environment creates the setting for transdisciplinary approaches for training and research, which is a foundational value for the Department and program.

30 SECTION 4: FACULTY

The following are faculty members in the PhD in Rehabilitation Science program who are primarily housed in the Department of Physical Therapy and Rehabilitation Science and in the Department of Physical Therapy at San Francisco State University:

Table 8: Faculty in UCSF Department of Physical Therapy and Rehabilitation Science & SFSU Department of Physical Therapy

Name Title Area of Expertise WOS Faculty, UCSF Motion analysis, neurorehabilitation, Diane Allen, PT, PhD Associate Professor, SFSU Multiple Sclerosis, tests and measures Focal dystonia, Parkinson’s disease, Nancy Byl, PT, MPH, PhD Professor and Chair Emeritus repetitive strain injury, CVA, outcomes research Assistant Professor Amber Fitzsimmons, PT, DPTSc Interprofessional education, geriatrics (joint appointment in Anatomy) Wendy Katzman, PT, DPTSc Associate Professor Osteoporosis, kyphosis, geriatrics WOS Faculty, UCSF Jeannette Lee, PT, PhD Oncology Assistant Professor, SFSU Professor Brain and spinal cord injury; Linda Noble, PhD (joint appointment in Neurological Surgery) injury and repair mechanisms WOS Faculty, UCSF Motion analysis, pediatric Sandra Radtka, PT, PhD Professor, SFSU neurorehabilitation Associate Professor Neuroscience, neuroinflammation, Susanna Rosi, PhD (joint appointment in Neurological Surgery) the aged brain Assistant Professor Betty Smoot, PT, DPTSc Breast cancer related lymphedema (joint appointment in Anatomy) Associate Professor Biomechanics, advanced quantitative Richard Souza, PT, PhD (joint appointments in Orthopaedic Surgery imaging, lower extremity overuse and Radiology and Biomedical Imaging) injuries Professor and Chair Cell biology of peripheral nerve, Kimberly Topp, PT, PhD (joint appointment in Anatomy) chemotherapy induced neuropathy WOS Faculty, UCSF Musculoskeletal rehabilitation; Linda Wanek, PT, PhD Professor and Chair, SFSU muscle cell biology

Faculty outside the Department of Physical Therapy and Rehabilitation Science must be vetted through an approval process. The faculty member will provide one letter of support from a current faculty member in the PhD in Rehabilitation Science program and one letter from the faculty member’s department chair, as well as a copy of a current CV. The letters should attest to the items in the criteria list below, and the letter from the chair should also describe available lab space and grant support. The application packet is reviewed by the PhD Program Steering Committee, and membership is voted on at quarterly meetings. In certain cases, prospective faculty members may be asked to give a seminar to the PhD in Rehabilitation Science community before admission is approved.

Basic criteria for inclusion in the PhD in Rehabilitation Science Program faculty includes:

1. Research relevant to one or both of the specializations in the PhD in Rehabilitation Science program (musculoskeletal biomechanics or clinically informed neuroscience). 2. NIH R01 support to ensure external peer review and support for a student’s project. 3. Confidence that the individual would be a suitable mentor for a graduate student, which may include such considerations as time devoted to research if the candidate will have clinical responsibilities, publication record, funding resources, training record, etc. 4. Membership in the UCSF Academic Senate (may be waived in certain cases).

31

Faculty membership is reviewed every three years and renewal is contingent upon demonstrated involvement in the PhD program. Opportunities for involvement include teaching in PhD courses and participation in journal clubs, attending PhD in Rehabilitation Science retreats, serving on Qualifying Examination, Graduate, or Dissertation Committees, participating in the student interview process, serving as a primary research mentor, or hosting students through their laboratory rotations.

The following are faculty outside the Department of Physical Therapy and Rehabilitation Science who will be initial members of the faculty in the PhD program in Rehabilitation Science:

Table 9: Faculty in the PhD Program Who Are Appointed in Other Departments at UCSF

Name Title Area of Expertise Professor and Director of Neurorehabilitation, Neurology Gary Abrams, MD Neurorehabilitation Rehabilitation Section Chief, San Francisco VA Medical Center Professor and Chair Neurological basis of pain and its Allan Basbaum, PhD Anatomy control Professor Michael Beattie, PhD Spinal cord injury Neurological Surgery Professor Jacqueline Bresnahan, PhD Spinal cord injury Neurological Surgery Associate Professor Chronic low back pain, degenerative Sibel Demir-Deviren, MD Orthopedic Surgery disc disease Assistant Professor Knee and shoulder orthopaedic Brian Feeley, MD Orthopaedic Surgery injuries, surgical procedures Assistant Professor Adam Ferguson, PhD Informatics and spinal cord injury Neurological Surgery Professor Donna Ferriero, MD Neonatal hypoxia/ ischemia Pediatrics Assistant Professor Karunesh Ganguly, PhD Neurorehabilitation Neurology Assistant Professor Kate Hamel, PhD Biomechanics and falls in the elderly Kinesiology, SFSU Professor Oncology and disease prevention; Robert Hiatt, MD, PhD Epidemiology and Biostatistics epidemiology and public health Bone microarchitecture, quantitative Assistant Professor Galateia Kazakia, PhD computed tomography, mechanisms of Radiology and Biomedical Imaging bone failure to load. Quantitative computed tomography, Professor Thomas Lang, PhD positron emission tomography, bone Radiology and Biomedical Imaging and muscle adaptations to stimuli. Signaling in pain sensory neurons; Professor Jon Levine, MD, PhD neural-endocrine control of Oral and Maxillofacial Surgery inflammation; musculoskeletal pain Post-traumatic osteoarthritis, Associate Professor Xiaojuan Li, PhD quantitative magnetic resonance Radiology and Biomedical Imaging imaging. Imaging of osteoporosis, imaging Professor Thomas Link, MD, PhD techniques for assessment of bone Radiology and Biomedical Imaging quality and density Professor Jialing Liu, PhD Stroke Neurological Surgery

32 Name Title Area of Expertise Professor Sports injuries, particularly running Anthony Luke, MD, MPH Orthopaedic Surgery overuse injuries Associate Professor Orthopaedic surgical approaches, Benjamin Ma, MD Orthopaedic Surgery post-traumatic osteoarthritis Professor Osteoporosis, osteoarthritis, radiology Sharmila Majumdar, PhD Radiology and Biomedical Imaging and quantitative imaging Professor and Chair Exercise and inflammation post- Mervyn Maze, MB ChB Anesthesia and Perioperative Care anesthesia Associate Professor Patrick McQuillen, MD Disorders of brain development Pediatrics/Critical Care Professor Christine Miaskowski, RN, PhD Pain and symptomatology in oncology Physiological Nursing Functional brain imaging, brain Associate Professor Sri Nagarajan, PhD plasticity, learning, sensorimotor Radiology and Biomedical Imaging control Professor Ion channels and nociceptors; Mark Schumacher, PhD, MD Anesthesia and Perioperative Care chronic pain Professor Excitotoxic and oxidative neuronal Raymond Swanson, MD Neurology death, Parkinson’s disease Professor Zena Vexler, PhD Neonatal stroke Neurology Professor Midori Yenari, MD Stroke Neurology

33 SECTION 5: COURSES

The following are present and proposed courses for the PhD in Rehabilitation Science (proposed courses are indicated with an asterisk). Given the relatively small class size of the PhD program (2 students every other year), there will be minimal to no impact on existing course loads.

Department of Physical Therapy and Rehabilitation Science

PT 251 Research Design (3.5 units) Instructor: Betty Smoot, PT, DPTSc This course explores the underlying theoretical concepts that guide the design of clinical research studies. Students will be introduced to the scientific method and to a variety of research methods and designs. Students will 1) learn research designs that will be applicable to their future physical therapy practice, 2) develop a research question and design an appropriate study for that question, and 3) learn to critically appraise and become proficient consumers of research literature.

PT 420 Mentored Research Concentration (2.5 units) Instructor: Varies Students have the option of pursuing a research concentration pathway. This pathway includes all requirements of the PT 419 Research Seminar. As a mentored research experience, students are both supervised and work alone or as part of a team on a research project. Research mentors include faculty within the UCSF/SFSU Graduate Program in Physical Therapy, UCSF/SFSU researchers outside of the Program, as well as faculty at consortium institutions.

*RS 100 Introduction to Rehabilitation Science (2 units) Instructor: Richard Souza, PT, PhD & Linda Noble, PhD The purpose of this course is twofold: 1) to provide an introduction to the areas of rehabilitation science research, and 2) to provide historical perspective on the major issues in rehabilitation science. Students will learn about resources and on-going research projects within the University. Students will also read classic papers of the last 150 years with the objective of understanding the fundamental discoveries that shape the discipline of rehabilitation science.

*RS 110 Principles and Applications of Evidence-based Practice (3 units) Instructor: Diane Allen, PT, PhD This course provides instruction on the principles of evidence-based clinical practice, and statistical methods reporting efficacy and effectiveness. Students learn hierarchical levels of evidence and complete a meta-analysis of research findings in an area of interest. The seminar component of the course will enable the student to delve deep into a topic related to his/her dissertation research area.

*RS 130 Basics in Musculoskeletal Imaging (3 units) Instructor: Richard Souza, PT, PhD The purpose of this class is to understand the principles behind various imaging procedures, and develop skills in looking at musculoskeletal images. These skills would be beneficial to the student exploring research careers in areas that use imaging as a tool or outcome. Course content will be provided in part through established coursework in the DPT curriculum (PT 210) but will include the addition of a weekly seminar with the Course Director to review the latest literature in musculoskeletal imaging.

*RS 150 Gross and Regional Anatomy (1 unit) Instructor: Kimberly Topp, PT, PhD This course provides an opportunity for students to investigate a regional of human anatomy, which has direct relevance to his/her area of research interest. The course includes mentored cadaveric dissection, radiological imaging of the same regional anatomy, ultrasound imaging and focused study of unembalmed material. The primary goals are to gain a deep understanding of the region of interest and to relate the knowledge to studies in

34 the Musculoskeletal Biomechanics or Clinically Informed Neuroscience tracks. Example foci are lower limb joints, nerve paths, spinal cord in situ.

*RS 200 Laboratory Rotation (5 units) Instructor: Various This course allows the students to rotate through different faculty laboratories to learn new instrumentation and scientific methodology as well as undertake an individual study with emphasis on special problems in rehabilitation science including areas related to the student's long term interests, future research interests or clinical specialization.

*RS 300 Doctoral Colloquium (1 unit) Instructor: Richard Souza, PT, PhD & Linda Noble, PhD PhD students in Rehabilitation Sciences program enroll in this seminar throughout their course of doctoral studies. This course provides a forum for discussion of the current research of students and faculty members, as well as discussions of practice influence on research and translation of research to practice. The course also serves as a forum for topics in professional development, including manuscript reviews; selection of journals for publication of one’s work; ethical decisions in publication, grant review, authorship; participation in professional organizations; best practices in teaching, research decisions, collaborations, mentoring; and scholarship and funding opportunities, strategies and decisions.

*RS 310 Teaching Practicum (1-4 units) Instructor: Varies Training in teaching in a course offered by the Graduate Program in Physical Therapy under the supervision of instructor in charge. Laboratory teaching, presentation of lecture material, experience in setting up and correcting of examinations, and participation in course are included.

*RS 330 Biomechanics of Human Motion (2 units) Instructor: Richard Souza, PT, PhD The course will introduce the student to concepts of mechanics as they apply to human motion. Primary areas of study will include anthropometry, kinematics, kinetics, muscle function, and muscle modeling. Emphasis will be placed on the biomechanics of locomotion using the inverse dynamics approach for calculating moments of force and joint power. The course will also provide practical experimentation and interpretation examples which build upon general biomechanical concepts (e.g. inverse dynamics). Weekly discussions will focus on the interpretation of these data and the extrapolation of these advanced concepts using clinical examples.

*RS 331 Running Biomechanics and Overuse Injuries - Journal Club (2 units) Instructor: Richard Souza, PT, PhD Students will have the opportunity to be part of an evidence-based approach to evaluating and treating running injuries through a comprehensive biomechanics evaluation. This course will consist of three parts: 1) observing UCSF RunSafe running assessments throughout the year; 2) reading, analyzing and presenting recent literature in a journal club format; and 3) processing, analyzing and presenting video-based running biomechanics data. The UCSF RunSafe and Running Biomechanics Elective will be mentored by Richard Souza, PT, PhD. The RunSafe observations and data processing will take place at the Human Performance Center at the Orthopaedic Institute on the Mission Bay campus. A final running biomechanics evaluation and presentation will be performed by all students that take this elective through evaluating of each others running form. This will be presented to Dr. Souza at the end of the elective and will be graded as pass or no pass.

*RS 340 Activity and Its Effects on CNS Disease/Injury Across the Lifespan (2 units) Instructor: Linda Noble, PT, PhD This reading-intensive mini-course, led by Linda Noble, PhD, will explore the interaction between defined activity and its effects on clinically relevant models of neurodegeneration, neural injury, and neuroinflammation. This 2- week course will review the current literature, led by faculty in the Departments of Physical Therapy and Rehabilitation Science, Neurological Surgery, Anatomy, Physiology and Neurology.

35

*RS 400 Topics in Clinically Informed Neuroscience (2 units) Instructor: Linda Noble, PT, PhD This mini-course will investigate the research literature that would support specific interventions in human disease, and the specific challenges in applying the research findings in the clinical environment. There will be discussion about the translation of bench research to clinical populations, as well as discussions of how clinical observations may inform and improve bench science. Course topics will be relevant for students in either the Musculoskeletal Biomechanics or the Clinically Informed Neuroscience track.

*RS 350 Research (1-8 units) Instructor: Varies Laboratory rotations for doctoral students enrolled in the PhD in Rehabilitation Science Program.

SFSU Department of Physical Therapy

PT 910 Evidence Based Practice (4 semester units) Instructor: Diane Allen, PT, PhD Students will continue the evidence-based review they started in PT 209, performing a meta analysis to answer their own research question. Students will present their findings orally and in a publication-style manuscript for the DPT culminating experience.

PT 960 Teaching Practicum (3 semester units) Instructor: Varies Develop necessary teaching skills for classroom, clinic, and laboratory. Students take this course at least twice and teach in the clinic at least one semester and in the classroom, one semester.

PT 996 Directed Studies (3 semester units) Instructor: Varies Development of research skills in preparation for doctoral laboratory original research. Student will be in a laboratory setting with faculty, post-doctoral and pre-doctoral students. Consists of seminars, journal clubs, and laboratory assignments.

PT 997 Research (2 semester units) Instructor: Varies Collection of data on original research project under the direction of dissertation advisor and dissertation committee. Determination of objectives and evaluation criteria by advisor based on stage of the project.

Department of Anatomy

ANA 207 Neuroscience (5 units) Instructor: Susanna Rosi, PhD The structural organization and function of the physiology of the central nervous system with an emphasis on the physiology of striated muscle and peripheral nerve relative to control mechanisms within the nervous system is presented. Emphasis is on clinical functional correlations of motor control.

Department of Bioengineering

BioE 25 Careers in Biotechnology (1 unit) This introductory seminar is designed to give freshmen and sophomores an opportunity to explore specialties related to engineering in the pharmaceutical/biotech field. A series of one-hour seminars will be presented by industry professionals, professors, and researchers. Topics may include biotechnology and pharmaceutical manufacturing; process and control engineering; drug inspection process; research and development; compliance and validation; construction process for a GMP facility; project management; and engineered solutions to

36 environmental challenges. This course is of interest to students in all areas of engineering and biology, including industrial engineering and manufacturing, chemical engineering, and bioengineering.

BioE 221 Tissue Mechanobiology (2.5 - 3.0 units) A central role for many tissues is to support physical forces (tension, compression, shear, pressure). This course will introduce the mechanisms by which cells respond to load; how these mechanisms are relevant to normal function & disease etiology; progression; prevention & treatment; an overview of tissue mechanics (relationships between force, stress/strain), mechanisms of cell/matrix interactions, examples of tissue modeling & remodeling in response to physical stimuli.

Department of Biomedical Imaging

BI 201 Principles of MR Imaging (4 units) This course aims to teach the basic principles behind magnetic resonance imaging. Topics taught physics of magnetic resonance, including resonance, excitation, and relaxation; image formation with excitation pulses and gradients fields; image reconstruction via the Fourier Transform (including review of Fourier Transform); MRI scanner hardware, including magnets and coils; image contrast; artifacts due to flow, motion, and field variations. Time-permitting, modern MRI techniques will also be covered, including fast imaging methods and multi-coil configurations.

BI 202 Physical Principles of CT, PET, and SPECT Imaging (4 units) This course is designed to provide the basic knowledge base to understand the physical principles of x-ray computed tomography (CT), positron emission tomography (PET), and single photon emission computed tomography (SPECT). Through “real” examples of how x-ray CT, PET, and SPECT are used in medical diagnosis and disease management, we will combine physical and mathematical foundations with actual applications for thorough understanding of the principles of these imaging techniques. Principles and developments of advanced CT, PET, and SPECT imaging technologies will be also discussed as integral parts of this course.

BI 240 Musculoskeletal Imaging (3 units) This course will utilize the basics learnt in the core imaging courses, and explore the specific theoretical and experimental needs for imaging the musculoskeletal system and tissues. It will focus on tissue composition, system function, and address quantitative imaging aspects that link imaging metrics to biochemistry, biomechanics, function and movement. The course will explore the role of imaging and image processing in understanding, and studying, musculoskeletal degeneration, aging, injury, as well as regenerative strategies, and therapeutic approaches.

Department of Biomedical Sciences

BMS 214 Ethics and the Responsible Conduct of Research (2 units) This course will cover topics related to the responsible conduct of research such as conflicts of interest, responsible authorship, policies regarding the use of human and animal subjects, handling misconduct, proper data management, research funding rules and procedures. Students will review and present case studies for class discussion.

BMS 225A Human Disease: Technologies & Biomedical Applications (1.5 units) Integrative course emphasizing technologies for cell & molecular biology and the application of these methods to understand human disease. Intended to provide a foundation for graduate students in methods used to understand human cells, tissues, & organs, and to illustrate how these methods illuminate physiology and pathobiology. Rather than a comprehensive course, selected topics will be discussed in depth. The emphasis may shift each year, depending upon which topics are relevant and timely.

BMS 225B Tissue and Organ Biology (3 units) An integrative course emphasizing frontiers in cell and molecular biology of human tissue and organ systems. It is

37 intended to provide a foundation in human anatomy, histology, immunology, physiology and pathobiology for graduate students. Rather than a comprehensive course, selected topics will be discussed in depth. The emphasis may shift each year, depending on which topics are relevant and timely.

BMS 255 Basic Genetics and Genomics (4 units) The scope of this graduate level course in genetics is to convey an understanding of basic genomics and molecular genetics, of the use of genetic animal model systems and of the analytical principles of simple and complex human genetic traits.

BMS 260 Cell Biology (4 units) The scope of this course is to convey an understanding of the function and organization of molecules and organelles inside and outside the cell and how these are used to construct a multicellular tissue and organ. The course will concentrate on questions related to how cells function, including how they grow, divide and die, and how they move, secrete and communicate.

Department of Biostatistics

Biostat 187 Intro Statistical Theory & Practice (5 units) Review of basic statistical theory, sampling, descriptive statistics, and probability. Presentation of confidence intervals, hypothesis testing, one- and two-factor analysis of variance, correlation, simple linear regression, and chi-square tests. A preparation for more advanced work.

Department of Epidemiology and Translational Science

EPI 150.03 Designing Clinical Research For Residents And Students (2 units) This course guides residents and students through the essential components for writing a clinical research protocol, developed around their own clinical research question. Students attend lectures and small group seminars as well as a peer review session in the last week of the course. The course will cover research questions, hypotheses, specific aims, study types, sample size estimation, power calculations, and data analysis.

EPI 218 Data Management for Clinical Research (1 units) Instruction in choosing the appropriate data management system, design of research data bases, options in data entry, form and report generation, computer security, and budgeting for data management personnel and equipment.

EPI 227 Building an Academic Career (0.5 units) Trainees learn about choosing a mentor, time management, generating finished projects, getting grants and getting a job; about how UCSF administration works, and about sources of clinical research funding including industry and foundations in addition to NIH and other government agencies.

Department of Microbiology

MICRO 204 Molecular and Cellular Immunology (3 units) Topics to be covered: hematopoiesis, structure and genetics of immunoglobulins, lymphocyte surface molecules, T cell receptors, signal transduction, antigen presentation, MHC restriction, tolerance, T cell effector mechanisms, lymphocynes, and autoimmunity.

Department of Neuroscience

NS 219 Special Topics in Basic and Translational Neuroscience (3 units) Each course offering will focus on the literature of a current important area of Neuroscience research. Students will be expected to read assigned papers critically before class and to present and discuss papers in class. Students will also be expected to write and present a brief research proposal based upon their reading. Topics in molecular,

38 cellular, developmental, systems and computational neuroscience, and neurological and behavioral disorders will be covered in separate course offerings.

NS 225 Neurobiology of Disease (3 units) Lectures and student-led discussions on physiological and molecular bases of diseases such as Alzheimer's, Parkinson's, multiple sclerosis, epilepsy, autism, addiction, triple repeat and prion diseases.

NS 245 Neurobiology of Behavior (3 units) Lectures and discussion of primary research concerning the neural basis of behavior. Topics will include basic concepts of learning and neuroethology with examples from vertebrate and invertebrate systems. A comparative approach will be taken to understanding psychological constructs such as drive, motivation and emotion. Emphasis is on neural circuit analysis of behaviors such as sound localization, drug self-administration and fear conditioning.

Department of Nursing

N 294B Medical Genetics for Nursing (3 units) Course addresses the genetic basis of human disease (cardiovascular, oncology, gerontology); genetic screening and diagnosis, ethical, legal and social implications related to genetic information and technology; ethnic, racial and cultural considerations for providing genetic services; and genetic therapeutics, such as, pharmacogenetics, gene therapy, stem cell transplants, enzyme replacement.

TICR Summer Clinical Research Workshop

EPI 150.03 Designing Clinical Research For Residents And Students (2 units) This course guides residents and students through the essential components for writing a clinical research protocol, developed around their own clinical research question. Students attend lectures and small group seminars as well as a peer review session in the last week of the course. The course will cover research questions, hypotheses, specific aims, study types, sample size estimation, power calculations, and data analysis.

BIOSTAT 212 Introduction to Statistical Computing in Clinical Research (1 unit) This course will introduce clinical researchers to the use of computer software for managing and analyzing clinical research data. Currently available statistical packages will be described and the roles of spreadsheet and relational database programs discussed. Use of STATA for managing, cleaning, describing, and analyzing data will be taught in lecture and laboratory sessions.

EPI 218 Data Management for Clinical Research (1 units) Instruction in choosing the appropriate data management system, design of research data bases, options in data entry, form and report generation, computer security, and budgeting for data management personnel and equipment.

EPI 227 Building an Academic Career (0.5 units) Trainees learn about choosing a mentor, time management, generating finished projects, getting grants and getting a job; about how UCSF administration works, and about sources of clinical research funding including industry and foundations in addition to NIH and other government agencies.

39 SECTION 6: RESOURCE REQUIREMENTS

Included with this proposal is the budget for the PhD in Rehabilitation Science program for five years (2016-2020). In 2016, we project two students entering the program, and one of these students will likely qualify for a merit- based scholarship. Both students will be supported by the block allocation provided by the Graduate Division, covering tuition and a stipend in the amount of $21,500 per student. Additional funding sources in 2016 to cover program expenses include Kean Foundation funding. In 2017, these same two students will move forward in the program, supported again by the block allocation from the Graduate Division, which will cover tuition and a stipend of $21,500 per student. Additional revenues for this year include projections for two students qualifying for merit-based scholarship funding, and internal reallocation of departmental discretionary funds (reserves) and/or development funds.

Two new students will be added to the program every other year. It is anticipated that all new students entering the program will be supported by the department for the first two years, and supported in subsequent years by grant funding from primary investigators’ grants. We project that by 2018 we will have secured a T-32 training grant and these funds will be used going forward to support students during the first two years of the program. Admission into the training program will be based upon qualifications and availability of slots at the time of application.

Faculty whose salaries are partially supported by state funding will be instructors in this program and there will be no impact to their participation in the current Doctor of Physical Therapy (DPT) program.

1) FTE Faculty The PhD Program team includes a Program Director and instructors, totaling the equivalent of 0.3 faculty FTEs. There will be no impact to the existing DPT program in this model.

2) Library Acquisition There are no anticipated additional costs for library acquisitions as most of the books and journals necessary for the PhD program are already available in the library or online. Students will have access to online resources for articles, such as PubMed and Google Scholar. The PhD in Rehabilitation Science program will also be supported by the online resources of the UC Digital Library system.

3) Computing Costs All students are expected to have a computer and internet access. A laptop or tablet is needed for on-campus class activities and homework. Student are expected to be experienced in using Microsoft Word, Excel, PowerPoint, the Web, Adobe Reader, Anti-virus software, and E-mail. Students receive the standard desktop support available from the UCSF Library and IT Services.

4) Equipment No additional equipment costs are anticipated.

5) Space and Other Capital Facilities Faculty: Office space to accommodate faculty and staff for the program is provided by the Department of Physical Therapy and Rehabilitation Science, as well as home departments of other faculty involved in the program (including Anatomy, Radiology and Biomedical Imaging, and Neurological Surgery).

Classes: Students will enroll in pre-existing courses, and the addition of two students will not require additional classroom space. Our students will be able to take advantage of the range of classrooms currently available to the Department faculty. Large classrooms are used for shared keynote lectures and educational activities and smaller rooms scheduled for breakout sessions.

40 6) Other Operating Costs Non-faculty payroll costs include 0.06 FTE of staff support (MSO, Finance Analyst, and Program Administrator).

7) Impact on Existing Doctor of Physical Therapy Degree Program There is no anticipated financial impact on the existing Doctor of Physical Therapy Degree Program.

41 SECTION 7: GRADUATE STUDENT SUPPORT

The PhD Program will cover the tuition costs and provide a $21,500 stipend during the first two years of the program using a combination of block funding provided by the Graduate Division, scholarship funds, and a T-32 training grant. After this point, the expectation is that students will join the primary research mentor’s grant with the same level of support (covering tuition plus a stipend).

The Program will encourage students to seek merit-based scholarship or fellowship funding during the first two years. The UCSF Graduate Division offers a range of scholarships in which PhD in Rehabilitation Science students will be eligible. They include:

● ARCS (Achievement Rewards for College Scientists) Scholarship - $12,000 stipend ● Chuan Lyu Chancellor’s Fellowship - $40,000 award ● CRCC (Cancer Research Coordinating Committee) Fellowship - $30,000 stipend ● DYFP (Dissertation-Year Fellowship Program) - $23,000 stipend ● Eugene Cota-Robles Fellowship - $14,000 stipend ● Fletcher Jones Fellowship - $20,000 stipend ● Graduate Research Mentorship Fellowship – $12,000 stipend ● Julius R. and Patricia A. Krevans Fellowship - $10,000 stipend ● Lloyd M. Kozloff Fellowship - $10,000 stipend ● Matilda Edlund Scholarship - $20,000 stipend ● NIGMS IMSD (Initiative for Maximizing Student Diversity) Program - $30,000 stipend ● Ralph H. Kellogg Endowed Chancellor’s Fellowship - $25,000 stipend

California PT Fund – up to $10,000 research grant

Foundation for Physical Therapy ● Florence P. Kendall Doctoral Scholarship – 1-year, $5,000 scholarship ● Promotion of Doctoral Studies (PODS) I Scholarship - 1-year, $7,500 scholarship ● Promotion of Doctoral Studies (PODS) II Scholarship - 1-year, $15,000 scholarship

42 SECTION 8: GOVERNANCE

The PhD program is being offered by a unit that offers graduate degrees.

43 SECTION 9: CHANGES IN SENATE REGULATIONS

None anticipated.

44 APPENDICES

Appendix A: PhD Budget for FY16-20

Appendix B: Equipment Available in the Physical Therapy Outpatient Practice

Appendix C: List of Proposed External Reviewers

Appendix D: Faculty Biosketches

Appendix E: Letters of Support from Schools, Departments and Programs

45 Appendix A: PhD Budget for FY16-20

PROPOSED PhD Program - Physical Therapy Consolidated Statement of Revenues, Expenses and Transfers FY16-FY20

Yr over Yr over Yr over FY2017 Yr % FY2018 Yr % FY2019 Yr over Yr % FY2020 Yr % FY2016 Budget Projection Variance Change Projection Variance Change Projection Variance Change Projection Variance Change Total Student Enrollment: 2 2 - 0% 4 2 100% 4 - 0% 6 2 50%

REVENUES: Graduate Division: Merit-Based 7,500 22,000 14,500 193% (22,000) -100% - 0% - 0% Graduate Division: Support (Block) Allocation 75,323 78,260 2,937 4% 80,376 2,116 3% 82,620 2,244 3% 82,620 - 0% Graduate Division: 1st Year Funding - 0% - 0% - 0% - 0% Other Revenues 60,000 42,000 (18,000) -30% 152,763 110,763 264% 135,788 (16,975) -11% 238,579 102,791 76% Kean Scholarship Gift Fund 60,000 - (60,000) -100% - 0% - 0% - 0% Departmental Reserves/Development 42,000 42,000 100% (42,000) -100% - 0% - 0% PI Grant Support (Rosi, Souza, Noble) - 0% 74,396 74,396 100% 74,396 - 0% 163,894 89,498 120% F-31 Grant (or T32 Grant) - 0% 78,367 78,367 100% 61,392 (16,975) -22% 74,685 13,293 22% TOTAL REVENUES 142,823 142,260 (563) 0% 233,139 90,879 64% 218,408 (14,731) -6% 321,199 102,791 47%

EXPENSES: # students supported 2 2 - 0% 4 2 100% 4 - 0% 6 2 50% Student Support Student Tuition/Fee 31,396 31,396 - 0% 77,894 46,498 148% 62,792 (15,102) -19% 124,392 46,498 98% Student Stipends 43,000 43,000 - 0% 86,000 43,000 100% 86,000 - 0% 129,000 43,000 50% Subtotal Student Support 74,396 74,396 0 0% 163,894 89,498 120% 148,792 (15,102) -9% 253,392 89,498 70%

Operating Expenses Payroll: FTEs 0.30 0.30 - 0% 0.30 - 0% 0.30 - 0% 0.30 - 0% Academic: 0% 0% Academic Salaries 40,208 40,208 - 0% 41,213 1,005 3% 41,213 - 0% 42,243 1,030 3% Academic Benefits 15,279 15,279 - 0% 15,661 382 3% 15,661 - 0% 16,053 392 3% Subtotal Academic 55,487 55,487 0 0% 56,874 1,387 3% 56,874 - 0% 58,296 1,422 3% FTEs 0.06 0.06 - 0% 0.06 - 0% 0.06 - 0% 0.06 - 0% Non-Academic: 0% Non-Academic Salaries 5,284 5,443 159 3% 5,606 163 3% 5,774 168 3% 5,948 173 3% Non-Academic Benefits 2,156 2,221 65 3% 2,287 67 3% 2,356 69 3% 2,427 71 3% Subtotal Non-Academic 7,440 7,663 223 3% 7,893 230 3% 8,130 237 3% 8,374 481 3% Subtotal Payroll 62,927 63,150 223 0% 64,768 1,617 3% 65,004 237 0% 66,670 1,903 3%

Non-Payroll: Computers for faculty and staff 2,215 2,282 66 3% 2,350 68 3% 2,421 71 3% 2,493 73 3% Data Network Recharge 177 182 5 3% 188 5 3% 194 6 3% 199 6 3% GAEL 485 499 15 3% 514 15 3% 529 15 3% 545 16 3% ISU Recharge 333 343 10 3% 353 10 3% 363 11 3% 374 11 3% Student recruitment 1,010 1,041 30 3% 1,072 31 3% 1,104 32 3% 1,137 33 3% Subtotal Non-Payroll 4,220 4,347 127 3% 4,477 130 3% 4,611 134 3% 1,137 138 -75%

Subtotal Operating Expenses 67,147 67,497 350 1% 69,245 1,747 3% 69,616 371 1% 67,807 2,041 -3%

TOTAL EXPENSES 141,543 141,893 350 0% 233,139 91,245 64% 218,408 (14,731) -6% 321,199 91,539 47%

Income/(loss) before transfers in(out) 1,280 367 (913) -71% 0 (366) -100% 0 (0) -26% (0) 11,252 -202%

TRANSFERS: Chancellor's Support - - - 0% - - 0% - - 0% - - 0% SOM Dean's Office Support - - - 0% - - 0% - - 0% - - 0% Other Departmental Support - - - 0% - - 0% - - 0% - - 0% Miscellaneous Transfers - - - 0% - - 0% - - 0% - - 0% Total transfers in/(out) 0 0 0 0% 0 0 0% 0 0 0% 0 0 0%

Year end income/(loss) 1,280 367 (913) -71% 0 (366) -100% 0 (0) -26% (0) 11,252 -202%

FUND BALANCES: Total fund balances, beginning of year - 1,280 1,280 100% 1,647 367 29% 1,647 0 0% 1,647 1 0% 0% 0% 0% Total fund balances, end of year 1,280 1,647 367 29% 1,647 0 0% 1,647 0 0% 1,647 11,253 0%

Per student operating cost $33,574 33,749 175 1% 17,311 (16,437) -49% 17,404 93 1% 11,301 (6,010) -35% Average per student support cost 37,198 37,198 - 0% 40,974 3,776 10% 37,198 (3,776) -9% 42,232 1,259 14% Appendix B: Equipment Available in the Physical Therapy Outpatient Practice

One important resource that students will be able to take advantage of while in the PhD Program is the successful clinical practice at the UCSF Mission Bay Outpatient Physical Therapy Practice, seeing over 21,000 physical therapy visits each year. The practice leadership and clinical providers are committed to supporting rehabilitation science research. The Outpatient Practice includes 15 practitioners, 11 of which have board-certified clinical specialties, including: Orthopaedic Clinical Specialists, Neurological Clinical Specialists, Certified Strength and Conditioning Specialists, Sports Certified Specialists, Performance Enhancement Specialists, and Certified Lymphedema Specialists.

Equipment available in the Outpatient Practice include:

● Alter-G body weight suspension treadmill ● PrimusRS by BTE ● FreeMotion Dual Cable Cross F624 ● Pilates Studio Reformer® By Balanced Body ● Pilates EXO® Chair by Balanced Body ● LeMond Fitness G-Force RT Recumbent Bike ● BIODEX Unweighing System and Active Trainer Harnesses by Guldmann ● Vertec (for vertical jump measurement) ● Agility ladder ● Large high low mat ● TRX Suspension Training ● BAPS Board Biomechanical Ankle Platform System ● Indo Board (for functional balance training) ● Stabilizer Pressure Biofeedback Unit by Chattanooga Group ● Trampoline ● BOSU ● Turf Cordz (for speed and resistance training) ● Leg Press ● Leg Curl ● Spin and Upright Bikes

Appendix C: List of Proposed External Reviewers for the PhD Proposal

Fabrisia Ambrosio, MPT, PhD Assistant Professor University of Pittsburgh Department of Physical Medicine & Rehabilitation 412-365-4850 [email protected]

Aileen Anderson, PhD Associate Professor University of California, Irvine Department of Anatomy and Neurobiology (949) 824-6750 [email protected]

Mary F. Barbe, PhD Professor Temple University Department of Anatomy and Cell Biology (215) 707-6422 [email protected]

Ann E. Barr-Gillespie, PT, DPT, PhD Vice Provost and Executive Dean Pacific Oregon University College of Health Professions 503-352-7372 [email protected]

James R. Carey, PT, PhD Professor Program in Physical Therapy University of Minnesota (612) 626-2746 [email protected]

Rebecca L. Craik, PT, PhD, FAPTA Professor and Chair Arcadia University Department of Physical Therapy [email protected]

Gammon M. Earhart, PT, PhD Associate Director, Movement Science PhD Program Associate Professor Washington University at St. Louis Departments of Physical Therapy, Neurology, Neurobiology (314) 286-1425 [email protected]

Ramona Hicks, PhD Program Director, Extramural Research Program NIH/NINDS [email protected]

Kornelia Kulig, PT, PhD, FAPTA Professor University of Southern California Division of Biokinesiology and Physical Therapy (323) 442-2911 [email protected]

Richard L. Segal, PT, PhD, FAPTA Professor and Chair Medical University of South Carolina Department of Health Professions College of Health Professions [email protected]

Appendix D: Faculty Biosketches

Enclosed Faculty Biosketches Include:

• Gary Abrams, MD, Professor and Director of Neurorehabilitation, Neurology • Diane Allen, PT, PhD, Associate Professor, Physical Therapy, SFSU • Allan Basbaum, PhD, Professor and Chair, Anatomy • Michael Beattie, PhD, Professor, Neurological Surgery • Jacqueline Bresnahan, PhD, Professor, Neurological Surgery • Nancy Byl, PT, MPH, PhD, Professor and Chair Emeritus, Physical Therapy and Rehabilitation Science • Sibel Demir-Deviren, MD, Associate Professor, Orthopaedic Surgery • Adam Ferguson, PhD, Assistant Professor, Neurological Surgery • Donna Ferriero, MD, Professor, Pediatrics • Amber Fitzsimmons, PT, DPTSc, Assistant Professor, Physical Therapy and Rehabilitation Science • Karunesh Ganguly, PhD, Assistant Professor, Neurology • Kate Hamel, PhD, Assistant Professor, Kinesiology, SFSU • Robert Hiatt, MD, PhD, Professor, Epidemiology and Biostatistics • Wendy Katzman, PT, DPTSc, Associate Professor, Physical Therapy and Rehabilitation Science • Galateia Kazakia, PhD, Assistant Professor, Radiology and Biomedical Imaging • Thomas Lang, PhD, Professor, Radiology and Biomedical Imaging • Jeannette Lee, PT, PhD, Assistant Professor, Physical Therapy, SFSU • Jon Levine, MD, PhD, Professor, Oral and Maxillofacial Surgery • Xiaojuan Li, PhD, Associate Professor, Radiology and Biomedical Imaging • Thomas Link, MD, PhD, Professor, Radiology and Biomedical Imaging • Jialing Liu, PhD, Professor, Neurological Surgery • Anthony Luke, MD, MPH, Professor, Orthopaedic Surgery • Benjamin Ma, MD, Associate Professor, Orthopaedic Surgery • Sharmila Majumdar, PhD, Professor, Radiology and Biomedical Imaging • Marvyn Maze, MB ChB, Professor and Chair, Anesthesia and Perioperative Care • Patrick McQuillen, MD, Associate Professor, Pediatrics and Critical Care • Christine Miaskowski, RN, PhD, Professor, Physiological Nursing • Srikantan Nagarajan, PhD, Associate Professor, Radiology and Biomedical Imaging • Linda Noble, PhD, Professor, Physical Therapy and Rehabilitation Science • Sandy Radtka, PT, PhD, Professor, Physical Therapy, SFSU • Susanna Rosi, PhD, Associate Professor, Physical Therapy and Rehabilitation Science • Mark Schumacher, PhD, MD, Professor, Anesthesia and Perioperative Care • Betty Smoot, PT, DPTSc, Assistant Professor, Physical Therapy and Rehabilitation Science • Richard Souza, PT, PhD, Associate Professor, Physical Therapy and Rehabilitation Science • Raymond Swanson, MD, Professor, Neurology • Kimberly Topp, PT, PhD, Professor and Chair, Physical Therapy and Rehabilitation Science • Zena Vexler, PhD, Professor, Neurology • Linda Wanek, PT, PhD, Professor and Chair, Physical Therapy, SFSU • Midori Yenari, MD, Professor, Neurology

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Gary M. Abrams Professor eRA COMMONS USER NAME Rehabilitation Section Chief ABRAMSG EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) State University of New York, Buffalo BA 1970 Psychology University of Pittsburgh MD 1974 Medicine Columbia University 1975-1978 Neurology Columbia University/National Institute for 1979-1981 Neuroendocrinology/

Medical Research, London, UK Peptide Chemistry

A. Personal Statement I have long-standing interest and experience in the clinical investigation of techniques for neurological evaluation and neural compensation and repair, particularly as it relates to the functional consequences associated with acquired brain injury (ABI). During my career, I have worked collaboratively with many investigators in the areas of stroke recovery, brain injury and pain management, with research that has included novel orthotics, robotics, and rehabilitation therapy interventions. As an educator, I have actively participated in the training of medical students, pre-doctoral physical therapy graduate students, and post- doctoral trainees in multiple disciplines. I have mentored 2 recent VA Research Career Development Awardees, who are currently clinical investigators in the neurological rehabilitation field. I have been particularly interested in fostering interdisciplinary collaboration of neuroscientists, physical therapists, engineers, psychologists, etc in the San Francisco Bay Area in order to address multi-faceted problems associated with restoration of participation and community reintegration for individuals with disabilities.

Time and Effort: 35% Research; 45% Clinical; 10% Administrative; 10% Teaching

B. POSITIONS and HONORS: 1980-1986 Assistant Professor of Neurology, College of Physicians & Surgeons, Columbia University, New York, NY. Assistant Attending Neurologist, Columbia-Presbyterian Medical Center, New York, NY. 1982-1995 Attending Neurologist, Helen Hayes Hospital, West Haverstraw, New York. 1986-1993 Medical Director and Chief of Columbia-Presbyterian Medical Services; Chief of Neurorehabilitation, Helen Hayes Hospital, West Haverstraw, NY. 1987-1995 Associate Professor of Clinical Neurology, College of Physicians & Surgeons, Columbia University, New York, NY. Associate Attending Neurologist, Columbia- Presbyterian Medical Center, New York, NY. 1995 - Associate Professor of Clinical Neurology, University of California, San Francisco, San Francisco, CA. Attending Neurologist, University of California Medical Center, San Francisco, CA. 1995-2000 Director of Rehabilitation Medicine, UCSF/Mount Zion Medical Center, San Francisco, CA. 1997-2000 Chief of Neurology, UCSF/Mount Zion Medical Center, San Francisco, CA. 2000- Rehabilitation Section Chief, San Francisco Veteran Affairs Medical Center, San Francisco, CA. 2001- Director, Neurorehabilitation Clinic, University of California Medical Center, San Francisco, CA. 2010 Professor of Clinical Neurology, University of California, San Francisco, San Francisco, CA

PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Other Experience and Professional Memberships American Academy of Neurology, Fellow World Federation for NeuroRehabilitation Society for Neuroscience Consultant, Orthopaedic and Rehabilitation Devices Panel, Food and Drug Administration, 1997-present Consultant Cardiovascular Devices Panel, Center for Devices and Radiological Health, Food and Drug Administration, 2003-present American Society for Neurorehabilitation, Certified; Board of Directors – 2009- VA Rehabilitation Research and Development Service, Scientific Review Committee, Brain Injury Research Washington. 2009, 2010. Chair, Chronic TBI Section 2012

Honors 1970 Phi Beta Kappa, Upsilon Beta 1974 Student Scientific Day Award, Upjohn Company, University of Pittsburgh 1978 Chief Resident, Neurological Institute of New York, Columbia University 1980-1985 Teacher Investigator Development Award, NIH/NINCD, #NS00478 1993 Fellow, American Academy of Neurology 2001 Robert B. Layzer Outstanding Teacher Award, UCSF Department of Neurology 2007 Haile T. Debas UCSF Academy of Medical Educators – Award for Excellence in Mentoring and Advising. 2011-2014 SGE: VA Rehabilitation Research and Development Service Scientific Merit Review Board: Traumatic Brain Injury and Stroke.

B. SELECTED PUBLICATIONS: (Selected from 64 peer-reviewed publications)

1. Byl NN, Gerber J, Chan M, Hanny M, Kottler J, Smith A, Tang M, Abrams G. Effectiveness of upper limb rehabilitation based on the principles of neuroplasticity: Patients six months post stroke. Neurorehabil Neural Repair 2003;17:6-191. 2. Piper M, Abrams GM, Marks WJ. Deep brain stimulation for the treatment of Parkinson’s disease: Overview and impact on gait and mobility. Neurorehabilitation 2005;20:223-232. 3. Chen A, Abrams GM, D’Esposito M. Re-integration of prefrontal networks for enhancing recovery after brain injury. J Head Trauma Rehabil 2006;2:107-118. 4. Byl NN, Pitsch EA, Abrams GM: Functional outcomes can vary by dose: Learning based sensorimotor training for patients stable post stroke. Neurorehabil Neural Repair 2008;22:494-504 5. Gorman S, Radtka S, Melnick M, Abrams GM, Byl NN. Development and validity of the Function In Sitting Test (FIST) in adults with acute stroke. J Neurologic Phys Ther 2010;34:150-160. 6. Chen A J-W, Novakovic-Agopian T, Nycum TJ, Song S, Turner G, Rome S, Abrams GM, D'Esposito M. Training of goal-directed attention regulation enhances control over neural processing for individuals with brain injury. Brain 2011;134:1541-45. Epub 4/22/11:1-14. 7. Kim H, Miller LM, Byl N, Abrams GM, Rosen J. Redundancy resolution of the human arm and an upper limb exoskeleton. IEEE Trans Biomed Eng. 2012 Jun; 59(6):1770-9. 8. Novakovic-Agopian T, Chen A J-W, Rome S, Rossi A, Abrams G, D’Esposito M, Turner G, McKim R, Muir J, Hills N, Kennedy C, Garfinkle J, Murphy M, Binder D, Castelli H. Assessment of sub-components of executive functioning in ecologically valid settings: The Goal Processing Scale. J Head Trauma Rehab 2012;27:1-11 9. Stein RB, Everaert DG, Abrams GM, Dromerick AW, Elovic EP, Francisco G, Hafner BJ, Hegde S, Herman R, Huskey T, Munin MC, Nolan KJ, Kufta C. Effect of a foot drop stimulator and ankle-foot orthosis on walking ability after stroke: a multicenter randomized controlled trial. Neurorehabil Neural Repair 2013 DOI: 10.1177/1545968313481278. 10. Byl NN, Abrams GM, Pitsch E, Fedulow I, Kim H, Simpkins M, Nagarajan, S, Rosen J. Chronic stroke survivors achieve comparable outcomes following virtual task specific repetitive training guided by a wearable robotic orthosis (UL-EXO7) and actual specific repetitive training guided by a therapist. J Hand Therapy 08/2013; DOI:10.1016/j.jht.2013.06.001 PHS 398/2590 (Rev. 11/07) Page Continuation Format Page 11. Ganguly K, Byl NN, Abrams GM. Neurorehabilitation: Motor recovery after stroke as an example. Ann Neurol DOI:10.1002/ana.23994. 12. Kim H, Miller LM, Fedulow I, Simkins M, Abrams GM, Byl N, Rosen J. Kinematic data analysis for post stroke patients following bilateral rehabilitation with an upper limb wearable robotic system. Trans Neural Sys Rehab Eng 2013;21:153-164. 13. Simkins M, Kim H, Abrams G, Byl N, Rosen J. Robotic unilateral and bilateral upper-limb movement training for stroke survivors afflicted by chronic hemiparesis. IEEE Int Conf Rehabil Robot. 2013 Jun;2013:1-6 14. Simkins M, Ryan J, Kim H, Abrams G, Byl N, Rosen J. Pre-clinical trial assessment tool for rehabilitation robotics. Proc 6th Ann Dynamic Systems Control Conf (In press) 15. Bethoux F, Rogers HL, Abrams GM, Annaswamy T, Arora AK, Brandstater M, Browne B, Burnfield J et al. The effects of a peroneal nerve functional electrical stimulation versus ankle-foot orthosis wear on gait performance and quality of life at 6 months in patients with chronic stroke: a randomized trial. Neurorehabil Neural Repair (in press)

Additional recent publications (in chronological order) 1. Ganguly K, Abrams GM. Management of chronic myelopathy symptoms and activities of daily living. Semin Neurol. 2012 Apr; 32(2):161-8. 2. Langford DJ, West, C. Elboim C, Cooper BA, Abrams G, Paul SM, Schmidt BL, Levine JD, Merriman JD, Dhruva A, Neuhaus J, Leutwyler H, Baggott C, Sullivan CW, Aouizerat BE, Miaskowski C. Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery. J Neurogenet 2014 Jan 7. 3. Smoot B, Paul S, Aouzeriat B, Elboim C, Levine J, Abrams G, Hamolsky D, Neuhaus J, West C, Topp K, Miaskowski C. Side of cancer does not influence limb volumes in women prior to breast cancer surgery. Lymph Res Biol (in press) 4. Miaskowski C, Paul SM, Cooper B, West C, Levine JD, Elboim C, Hamolsky D, Abrams G, Luce J, Dhruva A, Langford DJ, Merriman JD, Kober K, Baggott C, Aouizerat BE: Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery. Eur J Oncol Nurs (in press)

Research Support:

Ongoing Research Support VA SDR-04-408 (Seal PI) 10/01/10-09/30/14 Neuropsychological Screening of OEF/OIF Veterans in VA Primary Care To examine the reliability, validity, and sensitivity of the VA TBI screen used in the primary care setting for identifying TBI and cognitive symptoms and to examine issues relating to overlap with current mental health diagnoses Role: Co-Investigator

VANCHCS Project # B7467I (D'Esposito PI) 10/01/10-09/30/14 Neural Bases of Cognitive Rehabilitation for Brain Injury Extension of work investigating neurophysiological correlates of cognitive rehabilitation strategy using functional MRI. Role: Co-Investigator

NIH/NCI R01 CA 151692 (Miaskowski PI) 04/01/11-03/31/16 Characterization of and Treatment for Chemotherapy Neuropathy Clinical investigation of chemotherapy neuropathy including pilot trial of phototherapy Role: Co-Investigator

DoD W81XWH-11-2-0145 (Batki PI) 07/01/13-12/31/14 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans with TBI

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Clinical trial of topiramate as adjunctive treatment for hazardous alcohol use in veterans. Role: Co-Investigator

VA 1IO1RX001111-01A1 (Novakovic-Agopian PI) 01/01/13-12/31/15 Rehabilitation of Executive Functioning in Veterans with PTSD and TBI Trial of novel cognitive rehabilitation program to enhance emotional regulation in symptomatic control of post- traumatic stress disorder. Role Co-Investigator

NIH/NINDS U10 NS086494-0 (Smith PI) 10/01/13-09/30/18 Nor-Cal – Coordinating Stroke Center

UCSF is site for NINDS sponsored Stroke Trial Network. Will be team member leading evaluation and participation in future trials investigating issues related to stroke rehabilitation and recovery. Role: Co-Investigator

Completed: Innovative Neurotronics NCIRE#001599 05/01/11-06/30/13 Randomized Trial of the Innovative Neurotronics WalkAide Compared to Conventional Ankle-Foot Orthosis (AFO) in Stroke patients (INSTRIDE)

Multi-center randomized trial of FES-based AFO with conventional AFO for treatment of foot-drop following stroke. Role: PI.

R01 CA118658 - NIH/NCI (Miaskowski PI) 07/01/06-06/30/11 Long-Term Arm Morbidity Following Breast Cancer Treatment.

Determine prevalence, severity, and the timing of lymphedema (LE); changes in shoulder mobility/grip strength associated with LE; compare behavioral symptoms, functional status, and quality of life in women who develop LE; elucidate genetic markers for neuropathic pain and LE following breast cancer surgery. Role: Co-Investigator

VA RCDA (Chen PI) 07/01/06-06/03/10 Investigations of Rehabilitation Induced Plasticity in Brain Networks.

Study of behavior induced changes after TBI using neurophysiological monitoring with fMRI Role: Co-Mentor for VA RCDA

UC-CITRIS Seed Funding (Rosen PI) 07/01/10-06/30/11 Paradigm Shift of Neurorehabilitation of Stroke Patients Using Wearable Robotics.

Trial of newly developed upper extremity robotic device for rehabilitation of chronic stroke patients testing robotic therapy vs. conventional physical therapy. Role: Co-PI

R24 HD039629 (RehabNet~West/NIH). 07/01/04-06/30/05 MR Imaging of Neuroplasticity with Stroke Rehabilitation.

Pilot study investigating metabolic, structural, and perfusion changes with magnetic resonance imaging following constraint induced upper extremity therapy for stroke. Role: PI

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Allen, Diane D Associate Clinical Professor—UCSF eRA COMMONS USER NAME (credential, e.g., agency login) Associate Professor—SFSU SFSUALLEN

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Post- Measurement in Boston University, Boston, MA doctoral 06/07 Rehabilitation Fellowship Education: Quantitative University of California, Berkeley PhD 06/05 Measurement and Evaluation Medical Allied Health University of North Carolina, Chapel Hill MS 06/91 Services: Emphasis in Neuromuscular Science BS and University of California, San Francisco 06/78 Physical Therapy Certificate University of California, Santa Barbara 06/77 Pre-Physical Therapy

A. Personal Statement My areas of research and academic expertise are in qualitative and quantitative tests and measures, neuro- rehabilitation, and evidence-based practice. I am currently collaborating with other researchers in investigating the effects of Balance-Based Torso-Weighting on balance and gait for people with multiple sclerosis. As a recipient of one of the first PCORI grants (Patient-Centered Outcomes Research Institute), I am also investigating outcomes across six dimensions of movement for patients undergoing physical therapy. For this research, we have developed a computer-adaptive test (CAT) version of a patient-report instrument. We utilize this instrument to examine whether movement abilities improve more when the physical therapy episode of care focuses on the dimensions of movement with the largest patient-perceived gaps between current and preferred movement ability. I teach courses in the Doctor of Physical Therapy and Doctor of Physical Therapy Science programs and have mentored students in both programs as they pursue their own or collaborative research agendas. I also provide statistical consultation for students and colleagues. B. Positions and Honors Principals Positions Held 2008 present University of California San Associate Professor Graduate Program in Francisco/San Francisco State Physical Therapy University 2007 present Samuel Merritt University, Oakland, Adjunct Associate Department of Physical CA Professor Therapy 2007 present Kaiser Permanente Neurologic Instructor Physical Therapy Residency Program 2007 2008 University of California San Lecturer Graduate Program in Francisco/San Francisco State Physical Therapy University 1991 2007 Samuel Merritt College Adjunct Assistant Department of Physical Professor Therapy 2006 2007 School of Public Health, Boston Post-doctoral Fellow Health and Disability University Research Institute 2002 2005 University of California, Berkeley Graduate student Graduate School of researcher Education 2002 2003 Interim Health Care, San Jose, CA Contract Physical Therapist 2001 2002 University of California, Berkeley Graduate student researcher 1991 2000 Stanford University Hospital Contract Physical Therapist 1988 1990 Hillhaven Convalescent Center Staff Physical Therapist 1989 1990 University of North Carolina at Graduate Assistant Division of Occupational Chapel Hill Instructor Therapy 1987 1988 University of North Carolina at Graduate Assistant Division of Physical Chapel Hill Therapy 1985 1987 Medical Personnel Pool, Raleigh, Contract Physical North Carolina Therapist 1982 1985 Holy Cross Hospital, Austin, Texas Contract Physical Home Health Department Therapist 1982 1985 Nursefinders of Austin, Inc., Austin, Staff Physical Texas Therapist 1982 1982 Texas School for the Deaf, Austin, Physical Therapist Texas 1981 1981 Christian Medical College and Instructor, Clinical Hospital, Vellore, India Coordinator, and Staff Physical Therapist 1978 1981 Goleta Valley Community Hospital, Staff Physical Goleta, California Therapist C. Selected Peer-Reviewed Publications 1. Crittendon A, O'Neill D, Widener GL, Allen DD. Standing data disproves biomechanical mechanism for balance-based torso-weighting. Arch Phys Med Rehabil. 2014;95:43-49. 2. Allen DD, Widener GL. Tone Abnormalities. In: Cameron MH, ed. Physical Agents in Rehabilitation. 4th ed. St. Louis, MO: Elsevier; 2012. Chapter 5. 3. Hallum A, Allen DD. Neuromuscular Diseases. In Umphred DA, Burton GU, Lazaro RT, Roller ML, eds. Umphred's Neurological Rehabilitation, 6th ed. St. Louis, MO: Elsevier; 2012. Chapter 16. 4. Allen DD, Wagner JM. Assessing the gap between current movement ability and preferred movement ability as a measure of disability. Phys Ther. 2011;91:1789-1803. 5. Katz PP, Radvanski DC, Allen D, et al. Development and validation of a short form of the Valued Life Activities Disability Questionnaire for rheumatoid arthritis. Arthritis Care Res. 2011;63:1664-1671. 6. Tyner T, Allen DD. Balance Disorders and Fall Risk. In Cameron MH, Monroe L eds. Physical Rehabilitation for the Physical Therapist Assistant. St. Louis, MO: Elsevier; 2010. 7. Ewert T, Allen DD, Wilson M, et al. Validation of the International Classification of Functioning Disability and Health framework using multidimensional item response modeling. Disabil Rehabil. 2010;32(17):1397- 1405. 8. Allen DD. Using item response modeling methods to test theory related to human performance. J Appl Meas. 2010;11(2):99-111. 9. Allen DD, Cott CA. Evaluating rehabilitation outcomes from the client's perspective by identifying the gap between current and preferred movement ability. Disabil Rehabil. 2010;32(6):452-461. 10. Widener GL, Allen DD, Gibson-Horn C. Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis. Neurorehabil Neural Repair. 2009;23(8):784- 791. 11. Widener GL, Allen DD, Gibson-Horn C. Balance-based torso-weighting may enhance balance in persons with multiple sclerosis: preliminary evidence. Arch Phys Med Rehabil. 2009;90:602-609. 12. Allen DD, Mulcahey MJ, Haley SM, DeVivo MJ, Vogel LC, McDonald C, Duffy T, Betz RR. Motor function after pediatric spinal cord injury. Spinal Cord. 2009;47:213-217. 13. Allen DD, Gorton GE, Oeffinger DJ, Tylkowski C, Tucker CA, Haley SM. Analysis of the Pediatrics Outcomes Data Collection Instrument (PODCI) in ambulatory children with cerebral palsy using confirmatory factor analysis and item response theory methods. J Pediatr Orthop. 2008;28:192-198. 14. Allen DD, Ni P, Haley SM. Efficiency and sensitivity of multidimensional computerized adaptive testing of pediatric physical functioning. Disabil Rehabil. 2008;30(6):479-484. 15. Allen DD, Widener GL. Tone Abnormalities. In Cameron MH. Physical Agents in Rehabilitation: From Research to Practice, 3rd ed. St. Louis, MO: Saunders; 2008. Chapter 4. 16. Allen DD. Responsiveness of the Movement Ability Measure, a self-report instrument proposed for assessing movement across diagnoses and ability levels. Phys Ther. 2007;917-924. 17. Allen DD. Validity and reliability of the Movement Ability Measure, a self-report instrument proposed for assessing movement across diagnoses and ability levels. Phys Ther. 2007;899-916. 18. Allen DD. Proposing six dimensions within the construct of movement in the Movement Continuum Theory. Phys Ther. 2007;888-898. 19. Tyner T, Allen DD. Balance Disorders and Fall Risk. In Cameron MH, Monroe L eds. Physical Rehabilitation Assessment and Intervention: An Evidence-Based Approach. St. Louis, MO: Elsevier; 2007. Chapter 13. 20. Wilson M, Allen DD, Li JC. Improving measurement in health education and health behavior research using item response modeling: comparison with the classical test theory approach. Health Education Research. 2006;21(Supplement 1):i19-i32. 21. Mâsse LC, Allen DD, Wilson M, Williams GC. Introducing equating methodologies to compare test scores from two different self-regulation scales. Health Education Research. 2006;21(Supplement 1):i110-i120. 22. Baranowski T, Allen DD, Mâsse L, Wilson M. Does participation in an intervention affect responses on self-report questionnaires? Health Education Research. 2006;21(Supplement 1):i98-i109. 23. Allen DD, Wilson M. Introducing multidimensional item response modeling in health education research. Health Education Research. 2006;21(Supplement 1):i73-i84. 24. Wilson M, Allen DD, Li JC. Improving measurement in behavioral sciences using item response modeling: introducing item response modeling. Health Education Research. 2006;21(Supplement 1):i4-i18. 25. Pyle GG, Paaso B, Anderson BE, Allen D, et al. Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses. Clinical Gastroenterology and Hepatology. 2005;3(7):679-686. 26. Pyle GG, Paaso B, Anderson BE, Allen DD, et al. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology. 2005;3(7):687-694. 27. Allen DD, Widener GL. Tone Abnormalities. In: Cameron MH. Physical Agents in Rehabilitation: From Research to Practice, 2nd ed. St. Louis, MO: Saunders; 2003. Chapter 4. 28. Allen DD, Widener GL. Tone Abnormalities. In Cameron MH. Physical Agents in Rehabilitation: From Research to Practice. Philadelphia: W. B. Saunders; 1999. Chapter 5. 29. Martin SC, Marquez FA, Ordonio MA, Allen DD. Measuring functional range of motion in ballet dancers' hips. J of Dance Medicine and Science. 1998;2(2):56-62. 30. Gross MT, Sekerak DK, Allen DD. Effect of including a clinical example on the ability of physical therapists to apply information in a technical research report. Phys Ther. 1994;74:963-968. D. Research Support On-going Research Support Pilot Grant Allen (PI) 10/31/2012 - 12/31/2014 Patient-Centered Outcomes Research Institute Mind the Gap—Targeting Differences in Patients’ Current and Preferred Abilities Role:PI Completed Research Support R15HD066397 Widener (PI) 09/16/2010 - 09/15/2013 National Institute of Child Health and Human Development Movement Ability Changes with Balance-Based Torso-Weighting in Multiple Sclerosis. Role:Co-PI IM101137 Katz (PI) 01/01/2008 - 01/01/2010 Bristol-Myers Squibb Research and Development Global Epidemiology and Outcomes Research. Development and Validation of a Short-Form Valued Life Activity Disability and Task Modification Instrument (VLA-SF) for Use among Individuals with Rheumatoid Arthritis Role:consultant, research design, data analysis Greenwald (PI) 01/01/2011 - 12/31/2011 California Physical Therapy Fund Motor Imagery for Gait Improvement in Acute Stroke Rehabilitation: a Randomized Controlled Trial Role:Collaborator

Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2 (key personnel). Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Allan I. Basbaum Professor and Chair eRA COMMONS USER NAME Abasbaum EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) McGill University, Montreal, Canada BSc 1968 Psychology Univ. Pennsylvania, Philadelphia PhD 1972 Psych/Anatomy Univ. College London, United Kingdom Postdoc 1972-74 Neurophysiology Univ. California, San Francisco Postdoc 1974-77 Neuroanatomy

A. Personal Statement

My laboratory examines the mechanisms through which tissue and nerve injury produce changes in the peripheral and central nervous system, resulting in persistent pain. The hallmark of our work is its multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically modified mice. Recently, we developed a transgenic mouse in which wheat germ agglutinin transneuronal labeling of complex circuits can be triggered from neurons in any region of the brain or spinal cord, during development or in the adult. We are using these mice to study the development and adult organization of CNS circuits engaged by small diameter primary afferent nociceptors (“pain fibers”) and to study their modifications after tissue or nerve injury. In the course of our work we use a host of behavioral tests to study pain processing. Most recently, we have turned out attention to the possibility of overcoming the neurological consequences of peripheral nerve damage, by transplanting embryonic cortical GABAergic precursor cells into the spinal cord, a procedure that we find can ameliorate the persistent pain associated with nerve damage.

B. Positions and Honors

1966-1968 Research Assistant (Ronald Melzack), McGill University 1972-1974 Postdoctoral Fellow, (Patrick D. Wall) Univ. College London 1974-1977 N.I.H. Postdoctoral Fellow (Howard Fields), UCSF 1977-‘80/1980-‘84 Assistant/Associate Prof, Depts. Anatomy and Physiology, UCSF 1984-1997 Professor, Dept. Anatomy (joint appt. in Dept. Physiology), UCSF 1998 to present: Professor and Chair, Department of Anatomy, UCSF

N.I.H. Research Career Dev. Award (1978); Alfred P. Sloan Fellow (1979); Jacob Javits Invest. Award (1985- 92; 1992-99; 2007-2014); SFN Public/Special Lecturer (1986; 1997); UCSF Medical School Teaching Awards (1987-2002); F.W. Kerr Memorial Prize of the American Pain Soc. (1993); Bristol-Myers Squibb Prize for Distinguished Achievement in Pain Research (1994); John Bonica Distinguished Lecture and Prize (2002); Editor-in-Chief: Pain (2003-present); Fellow, Amer. Acad. Arts and Sciences (2003); Member, Inst. of Medicine (2005); Fellow, Royal Society, UK (2006); Fellow, British Acad. Medical Sciences (2007); Ynvge Zotterman Prize, Stockholm Physiol. Soc. (2007); Fellow, American Assoc. Anatomists, (2009); Joseph Erlanger Lecture, Amer Physiol. Soc, (2010); Fellow, American Assoc Advancement Science (2010); Faculty Lecturer, UCSF (2012), Founder’s Award, American Academy of Pain Medicine, 2013

PHS 398/2590 (Rev. 06/09) Page

Program Director/Principal Investigator (Last, First, Middle):

C. Selected Publications

1. Malmberg, A.B., Chen, C., Tonegawa, S. and Basbaum, A.I. 1997 Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science 278: 279-283. http://preview.ncbi.nlm.nih.gov/pubmed/9323205?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa nel.Pubmed_RVDocSum&ordinalpos=13 2, Liu, H., Mantyh, P.W. and Basbaum, A.I. 1997 NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature 386:721-724. http://www.ncbi.nlm.nih.gov/pubmed/9109489?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPane l.Pubmed_RVDocSum&ordinalpos=5 3. Cao, Y.Q., Mantyh, P.W., Carlson, E.J., Gillespie, A.M., Epstein, C.J., Basbaum, A.I. 1998 Primary afferent tachykinins are required to experience moderate to intense pain. Nature 392:390-394. http://preview.ncbi.nlm.nih.gov/pubmed/9537322?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa nel.Pubmed_RVDocSum&ordinalpos=8 4. Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.F., Trafton, J.A., Petersen-Zeitz, K,R., Koltzenburg, M., Basbaum, A.I., Julius, D. 2000 Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306-313. http://www.ncbi.nlm.nih.gov/pubmed/10764638?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPan el.Pubmed_RVDocSum&ordinalpos=3 5. Braz, J.M., Nassar, M.A., Wood, J.N. and Basbaum, A.I. 2005 Parallel “pain” pathways arise from subpopulations of primary afferent nociceptor. Neuron 47: 797-793. http://www.ncbi.nlm.nih.gov/pubmed/16157274?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPan el.Pubmed_RVDocSum&ordinalpos 6. Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. 2008 Innocuous, not noxious, input activates PKCγ interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 28:7936-7944. http://www.ncbi.nlm.nih.gov/pubmed/18685019?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPan el.Pubmed_RVDocSum&ordinalpos=1 7. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. 2009 TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci (USA). 106:11330-11305. http://preview.ncbi.nlm.nih.gov/pubmed/19564617?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum&ordinalpos=4 8. Basbaum, A.I., Bautista, D.M., Scherrer, G., Julius, D. 2009 Cellular and molecular mechanisms of pain. Cell 139: 267-284. http://www.ncbi.nlm.nih.gov/pubmed/19837031?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa nel.Pubmed_RVDocSum&ordinalpos=1 9. Cavanaugh, DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. 2009 Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci, (USA) 106: 9075-9080. http://preview.ncbi.nlm.nih.gov/pubmed/19451647?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum&ordinalpos= 10. Seal, RP, Wang, X, Guan, Y, Raja, SN, Woodbury, CJ, Basbaum, AI, Edwards, RH. 2009 Low threshold C-mechanoreceptors are required for injury-induced mechanical hypersensitivity. Nature 462: 651-655. http://preview.ncbi.nlm.nih.gov/pubmed/19915548?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum&ordinalpos=1 11. Scherrer G, Imamachi N, Cao Y-Q, Contet C, Mennicken F, O’Donnell D, Kieffer BL, Basbaum AI. 2009 Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell, 137:1148-69. http://preview.ncbi.nlm.nih.gov/pubmed/19524516?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum&ordinalpos=5

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

12. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. 2010 VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci (USA) 2010 107:22296-222301 http://www.ncbi.nlm.nih.gov/pubmed/21135246 13. Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. 2011 Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain. 152:990-1000. http://www.ncbi.nlm.nih.gov/pubmed/21256675 14. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. 2011 Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 31:5067-5077. http://www.ncbi.nlm.nih.gov/pubmed/21451044 15. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury- induced neuropathic pain. Neuron. 2012 74:663-75. http://www.ncbi.nlm.nih.gov/pubmed/22632725 16. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI. 2013 Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron, 78: 312-324. http://www.ncbi.nlm.nih.gov/pubmed/23622066 17. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. 2013 TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing. Nature Neurosci. 16: 1284-1290. http://www.ncbi.nlm.nih.gov/pubmed/23872594http://www.ncbi.nlm.nih.gov/pubmed/22632725

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator: Beattie, Michael S.

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Beattie, Michael, Stephen Professor, Director of Research eRA COMMONS USER NAME (credential, e.g., agency login) BEATTIE01

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Davis B.S. 06/72 Biological Psychology Ohio State University M.A. 06/74 Neuropsychology Neuropsychology/ Ohio State University Ph.D. 06/77 Neuroanatomy NIH Ohio State University Postdoctoral 06/78 Neuroanatomy fellow Michigan State University Postdoctoral 06/79 Neurophysiology

A. Personal Statement I have been working on the cell biology of spinal cord injury and repair for many years, and have mentored numerous graduate students, postdocs, and residents, many of who have gone on to successful scientific and clinical careers. I have also served as the director of an NIH training grant and a Neuroscience Graduate Program (at Ohio State), and am currently a member of the UCSF Biomedical Sciences Program. Our laboratory is known for developing useful animal models for brain and spinal cord injury in rodents and non- human primates. The environment here at the Brain and Spinal Injury Center is ideal for combined scientific and clinical training, with basic scientists and physician-scientists working together to translate biomedical science into clinical practice at a level 1 trauma center. Current funded projects include 1) development of anti- inflammatory therapies for acute and chronic applications in brain and spinal cord injury, 2) development of the non-human primate model of cervical spinal cord injury with the California SCI Consortium, 3) development of models of chronic cervical spinal cord compression in rodents that will allow MR Imaging of treatment effects, 4) the effects of combined brain and spinal cord injury on neurological outcomes, 5) the role of de- and re- myelination in recovery from cord and brain trauma, 6) the role of synaptic plasticity in rehabilitation after SCI, 7) the effects of acute critical care and blood pressure management on outcomes after human and rodent SCI. The laboratory is actively seeking translational solutions to SCI and TBI, collaborating with BASIC physicians and scientists. The lab supports the research of fellows and residents in neurosurgery, anesthesiology, neurology, and radiology along with postdoctoral fellows, graduate students and a spectacular technical staff. My professional duties include service on editorial boards, NIH and foundation grant review boards, and service to the National Neurotrauma Society. My administrative and teaching duties are as Director of Research for BASIC, supervising and coordinating preclinical research projects and funding, and mentoring junior faculty, postdocs, and students. B. Positions and Honors Principals Positions Held 1992 1999 Ohio State University Professor Cell Biology, Neurobiology, and Anatomy and Neurological Surgery 2002 2006 Ohio State University Brumbaugh Neuroscience Professor and Chair 2003 2006 Ohio State University Director Neurobiology of Disease Institute

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Beattie, Michael S.

2003 2006 Ohio State University Director Neuroscience Graduate Program 2006 present University of California, San Professor Dept. of Neurological Francisco Surgery, Brain and Spinal Injury Center (BASIC) 2010 present University of California, San Director of Research UCSF Brain and Spinal Francisco Injury Center

Other Positions Held Concurrently 2007 present University of California, San Member, UCSF Francisco Biomedical Sciences Graduate Program 2008 present University of California, San Member, UCSF Francisco Institute for Regeneration Medicine

Honors Awards 1997 Rudolf Magnus Visiting Professor and Lecturer Rudolf Magnus Insititute, Univ of Utrecht, NL 2000 John D. and E. Olive Brumbaugh Chair of Brain Research Ohio State University College of and Teaching Medicine 2013 2012 Reeve-Irvine Research Medal for meritorious Reeve-Irvine Research Center, UC research in spinal cord injury Irvine

Memberships

Service to Professional Organizations 2012 2013 National Neurotrauma Society Vice-President C. Selected Peer-Reviewed Publications (from over 110) 1. Crowe, M.J., Bresnahan, J.C., Shuman, S.L., Masters, J.N., and Beattie, M.S. (1997) Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nature Med., 3: 73-76. 2. Beattie EC, Stellwagen D, Morishita W, Bresnahan J, Ha B-K, Von Zastrow M, Beattie MS*, Malenka RC* (2002) Control of synaptic strength by glial TNFalpha. Science, 295: 2282-2285. *co- corresponding authors. 3. Beattie MS*, Harrington AW*, Kim MS, Boyce SL, Longo F, Hempstead BL, Bresnahan JC, Yoon SO (2002) Pro-NGF induces p75-mediated death of oligodendrocytes following spinal cord injury, Neuron, 36: 375-386. *co-1st authors 4. Ferguson AR, Christensen RN, Miller BA, Sun F, Beattie EC, Bresnahan JC, Beattie MS (2008). Cell death after spinal cord injury is exacerbated by rapid TNF-alpha-induced trafficking of GluR2- lacking AMPARs to the plasma membrane. J. Neurosci., 28: 11391-11400. PMCID: PMC2598739 5. Beattie MS, Ferguson AR, Bresnahan JC. AMPA-receptor trafficking and injury-induced cell death. Eur J Neurosci. 2010 Jul; 32(2):290-7. 6. Sun F, Lin CL, McTigue D, Shan X, Tovar CA, Bresnahan JC, Beattie MS. Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. Glia. 2010 Aug 15; 58(11):1304-19. 7. Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 2010 Dec; 13(12):1505-10. 8. Beattie MS, Manley GT. Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy. Brain. 2011 May; 134(Pt 5):1259-61. 9. Nout YN, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Neilsen JL, Roy R, Zhong H, PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: Beattie, Michael S.

Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC (2012). Methods for functional assessment after cervical spinal cord hemisection in the Rhesus monkey. Neurorehab. Neural Repair, online ahead of print. 10. Stuck ED, Christensen RN, Huie JR, Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR (2012) Tumor necrosis factor alpha (TNFα) mediates GABAA receptor trafficking to spinal plasma membrane in vivo. Neural Plasticity, article ID 261345, doi:10.1155/2012/261345. 11. Gensel JC, Tovar CA, Bresnahan JC, Beattie MS (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury, PLoS One, 13 March 2012, 10.1371/journal.pone.0033519. 12. Huie JR, Baumbauer KM, Lee KH, Bresnahan JC, Beattie MS, Ferguson AR, Grau JW (2012) Glial tumor necrosis factor-alpha (TNFa) generates metaplastic inhibition of spinal learning. PLoS One, 7(6), e39751, Jun 20, 2012. 13. Ferguson AR, Irvine K-A, Gensel JC, Nielson JL, Lin A, Ly J, Segal MR, Bresnahan JC, Beattie MS (2013) Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PLoS One, 8(3) e59712. 14. Inoue T, Lin A, Ma X, McKenna SL, Creasey GH, Manley GT, Ferguson AR, Bresnahan JC, Beattie MS (2013) Combined SCI and TBI: Recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement. Exp. Neurol. 248: 136-147. D. Research Support On-going Research Support NS 038097 Beattie (PI) 06/01/2005 - 02/28/2016 NIH, NINDS Mechanisms of secondary damage in spinal cord injury The aims of this project include extending current studies of AMPAR trafficking in neurons to glial cells, further testing the hypothesis that membrane AMPAR trafficking effects are recruited over time and space by the expanding wave of secondary injury, and using drugs that affect different points in the sequence of TNFa- mediated CP-AMPAR insertion to expand the preclinical evaluation of this target for clinical application Role:PI 1R01 NS069537-01 Ferguson (PI) 03/01/2010 - 12/31/2014 NIH/NINDS Metaplasticity and recovery after spinal cord injury: cellular mechanisms The proposed project explores cellular mechanisms that regulate a form of spinal cord learning that is thought to contribute to recovery of function after SCI. Role:Beattie, co-I; Ferguson, PI No number Tuszynski (PI) 03/01/2010 - 02/28/2014 California spinal cord injury consortium VA Merit Award to Mark Tuszynski, San Diego VAHC (interagency personnel agreement) This IPA provides salary support for work on the VA-California SCI consortium, which has developed a non- humabn primate model of SCI. Animal work is done at UC Davis. Data analysis and evaluation is done at UCSF. Role:Bresnahan and Beattie, UCSF PIs 1R01 NS067092-01A1 Ferguson (PI) 07/01/2010 - 06/30/2015 NIH/NINDS Bioinformatics for translational spinal cord injury research By pooling data from several laboratories and making cross-species comparisons, we will leverage existing experimental data to identify common metrics of SCI that can be used for evaluating mechanism of SCI that translate across species. Role:Beattie, Co-I; Ferguson, PI No number 06/01/2010 - 05/31/2012

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator: Beattie, Michael S.

Veterans Administration Pilot Grant Development of cervical contusion model of SCI in primates (Bresnahan and Beattie, UCSF PIs (interagency agreement)) Role:Tuszynski, PI NS042291-A1 Bresnahan (UCSF PI) Tuszynski (PI) 08/15/2011 - 08/14/2016 NIH, NINDS Plasticity and regeneration in the primate spinal cord This project proposes to examine the molecular, physiological, and behavioral effect of cortical stimulation on the pattern of recovery of function after cervical hemisection in the primate spinal cord. Chronic intermittent cortical stimulation and chondroitinase treatments will be tested in this primate model of SCI. Role:Co-I, UCSF subcontract SRA Beattie (PI) 01/01/2012 - 06/30/2014 Sanofi-Aventis Sanofi-BASIC collaboration, project 1: Traumatic brain injury biomarkers This project examines the effects of SAR127963 on biomarkers of inflammation in peripheral blood monocuclear cells in TBI patients Role:PI SRA Beattie (PI) 01/01/2012 - 12/31/2013 Sanofi-Aventis Sanofi-BASIC collaboration project 2: Protection of oligodendrocytes with SAR127963 after TBI in rats Examine the neuroprotective effects of SAR127963 on oligodendrocytes after experimental TB I in th rat Role:PI A119405 Beattie (PI) 04/15/2012 - 04/01/2014 SanBio, Inc. SB623 cells in sub-acute and chronic cervical spinal cord injury. The neuroprotective efficacy of human SB623 mesenchymal derived stem cells will be tested in sub-acute and chronic unilateral cervical spinal cord contusion injuries using a battery of forelimb function tests and histological outcome measures. Role:PI SC120259 Beattie (PI) 10/01/2013 - 09/30/2016 DoD, CDMRP, SCIRP SC120259 - Effects of Early Acute Care on Autonomic Outcomes in SCI: Bedside to Bench and Back. This project will study human critical care practices, including blood pressure management, as predictors of outcome after SCI in patients at SF General Hiospital, and in parallel rodent work, determine the relationship between early mean arterial pressure and outcome after throacic contusion injuries. Role:PI

CHN 260965 Bresnahan (PI) 07/01/2013 - 06/30/2016 Craig H. Neilsen Foundation Neuroprotection in a contusion SCI model in the non-human primate. This award will fund the continued development of a uniltaeral cervical contsuion injury model of SCI in NHPs, and fund a trial of anti-TNF therapies. Role:Co-I Completed Research Support 1 R21 AG032518-02, Beattie (PI) 06/01/2009 - 05/31/2011 NIH, NIA Cervical spinal injury and demyelination in aged rats This project aims to develop a model of chronic cervical spondylosis in the rat. An MRI-compatible device is

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator: Beattie, Michael S. being developed that can produce incremental compression . This model will serve as a platform for developing therapeutics for this growing clinical problem. Role:PI

W81XWH-10-1-0910 Beattie (PI) 09/01/2010 - 08/31/2013 DoD/CDMRP SCIRP Translational Partnership Award Mild TBI and spinal cord injury: a bedside to bench approach to model development This translational partnership award will use information from clinical practice on combined TBI and SCI to develop animal models that can help predict effective treatments for combined injuries. Role:M. Beattie (initiating PI), G. Manley, G. Creasey, partner PIs

PHS 398/2590 (Rev. 06/09) Page 5 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Jacqueline C. Bresnahan, Ph.D. Professor eRA COMMONS USER NAME BRESNAHAN01 EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Kent State Univ., Kent, OH B.A. 1968 Psychology The Ohio State University, Columbus, OH M.A. 1970 Psychology The Ohio State University, Columbus, OH Ph.D. 1973 Psychology The Ohio State University, Columbus, OH Postdoc 1977 Neuroanatomy A. Personal Statement My research program has been a cooperative effort with Dr. Michael Beattie for many years. We have focused on understanding the biological responses of the spinal cord to injury including cell death and repair after trauma, and the process of recovery of function after injury. Our laboratory has participated in the development of a number of models to study this devastating injury, including a number of outcome measures currently in wide use in the field. In 2006, we joined the Brain and Spinal Injury Center at UCSF with the goal of focusing on translational research. At that time, we joined the California Spinal Cord Consortium and have participated in the development of the primate model of spinal cord injury with a special focus on the behavioral outcome measures. We have also now developed a contusion model of SCI in the NHP which can be used as a translational platform for testing both cell based and neuroprotective therapies that show promise in rodent models of SCI. B. Positions and Honors Professional Experience 1968-73 Teaching Assistant, Instructor & Research Associate, Dept. Psychology, Ohio State University. 1973-77 Post-Doctoral Fellow, Dept. of Anatomy, The Ohio State University 1977-84 Clinical Assistant Professor, Dept. of Anatomy, The Ohio State University. 1984-85 Clinical Associate Professor, Dept. of Anatomy, The Ohio State University. 1985-91 Associate Professor, Dept. of Anatomy, The Ohio State University 1991-1999 Professor, Dept. of Cell Biology, Neurobiology and Anatomy, The Ohio State University 1999-2006 Professor, Dept. of Neuroscience, The Ohio State University 2004-2006 Professor, Dept. of Psychology, The Ohio State University 2001-2006 Associate Dean for Basic Research, College of Medicine and Public Health, Ohio State Univ. 2006-present Professor Emeritus, Department of Neuroscience, The Ohio State University 10/2006-present Professor, Dept. of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, CA Honors and Awards: 1983 - 1987 Member, Neurological Disorders Program Project Review A Committee, NINDS, NIH 1985 Chairman, Site Visit Committee, NINDS, NIH 1985 Chairman, Special Study Section, NINDS, NIH 1991 Member, Special Review Panel, NIH 1978, 1980, 1982-85, 1987, 1989 Scientific Advisory Consultant, NINDS, NIH 1982, 1991 Member, Technical Merit Review Panel, NINCDS, NIH 1998 – 2002 Member, VA Merit Review Panel 2003 – 2008 Member, NSD-A Study Section, NINDS, NIH, Chair 2007-2008 1994 – 1999 Scientific Advisory Council, American Paralysis Assoc 1999 -present Member, Scientific Advisory Council, Christopher and Dana Reeve Foundation 2009 – 2012 Chair, Scientific Advisory Council, Christopher and Dana Reeve Foundation 2001 - 2006 Scientific Review Panel, Texas Institute for Rehabilitation Research, Mission Connect 1997 -present Scientific Advisory Board, Acorda Therapeutics PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): 1993 -present International Scientific Advisory Board, International Neurotrauma Society 1998 President, National Neurotrauma Society 2014 President, National Neurotrauma Society 1992-95, 1999-01, 2008-2011 Councilor, National Neurotrauma Society 2000 - 2006 Member, PPG External Advisory Board, University of Texas at Galveston 2001 - 2009 Member, COBRE Grant External Advisory Board, University of Louisville 2008 - 2012 Member PPG Internal Advisory Board, UCSF Editorial Board: Journal of Neurotrauma; Restorative Neurology and Neuroscience; Journal of Neurodegeneration and Regeneration; Guest Editorial Referee, Exp. Neurol., Brain Res., Science, J. Comp. Neurol., Neurosci., J. Neurosci., Neurosci. Lett.; Blood, Glia, J. Neurosci. Res., Nature Med., Ann. Neurol., PNAS 2003 Faculty Teaching Award, College of Medicine, The Ohio State University 2005 Neuroscience Teaching Award, Dept. of Neuroscience, The Ohio State University 2012 Reeve-Irvine Research Medal for Spinal Cord Injury Research C. Selected peer-reviewed publications (from over 100) Bresnahan, J.C., Beattie, M.S., Stokes, B.T. and Conway, K.C., (1991). Three-dimensional studies of graded contusion lesions of the rat spinal cord. J. Neurotrauma, 8:91-101. Behrmann, D.L., Bresnahan, J.C., and Beattie, M.S., (1992). Spinal cord injury produced by consistent mechanical displacement of the cord in rats: Behavioral and histologic analysis. J. Neurotrauma, 9:197- 217. Bresnahan, J.C., Behrmann, D.L., and Beattie, M.S., (1992). Studies of spinal cord contusion by consistent, rapid displacement of the cord surface: The Ohio State impact device. J.Neurotrauma, 8:197-217. Behrmann, D.L., Beattie, M.S., and Bresnahan, J.C., (1993). A comparison of YM-14673, U-50488, and nalmefene after spinal cord injury in the rat. Exp. Neurol, 119:258-267. Bresnahan, J.C., Behrmann, D.L. and Beattie, M.S., (1993). Anatomical and behavioral outcome after spinal cord contusion injury produced by a displacement controlled impact device. Restor. Neurol. & Neurosci., 5:76. Behrmann, D.L., Beattie, M.S., and Bresnahan, J.C., (1994). Modelling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone and YM14673. Exp. Neurol., 126:61-75. Campbell, H.L., Bresnahan, J.C., and Beattie, M.S., (1994). The distribution and morphology of sacral spinal cord neurons innervating pelvic structures in Xenopus laevis. J. Comp. Neur., 347:619-627. Basso, D.M., Beattie, M.S., and Bresnahan, J.C., (1995) A new sensitive locomotor rating scale for locomotor recovery after spinal cord contusion injuries in rats. J. Neurotrauma, 12: 1-21. Beattie, M.S., Bresnahan, J.C., Tovar, C.A., Koman, J., Van Meter, M. et al. (1997) Endogenous repair mechanisms after spinal cord contusion in rats. Exp. Neurol., 148:453-463. Crowe, M.J., Bresnahan, J.C., Shuman, S.L., Masters, J.N., and Beattie, M.S. (1997) Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nature Medicine, 3(1), 73-76. Beattie MS*, Harrington AW*, Kim MS, Boyce SL, Longo F, Hempstead BL, Bresnahan JC, Yoon SO (2002) Pro-NGF induces p75-mediated death of oligodendrocytes following spinal cord injury, Neuron, 36: 375- 386. . *co-1st authors Beattie EC, Stellwagen D, Morishita W, Bresnahan J, Ha B-K, Von Zastrow M, Beattie MS*, Malenka RC* (2002) Control of synaptic strength by glial TNFalpha. Science, 295: 2282-2285. *co-corresponding Nout, YS, Schmidt, MH, Tovar, CA, Culp, E, Beattie, MS, Bresnahan, JC (2005) Telemetric monitoring of corpus spongiosum penis pressures in conscious rats for assessment of micturition and sexual function following spinal cord contusion injury. J. Neurotrauma, 22, 429-441. Gensel JC, Tovar CA, Hamers FPT, Deibert RJ, Beattie MS, Bresnahan JC (2006) Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J Neurotrauma, 23: 36-54. Ferguson AR, Christensen RN, Miller BA, Sun F, Beattie EC, Bresnahan JC, Beattie MS (2008). Cell death after spinal cord injury is exacerbated by rapid TNF-alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. J. Neurosci. 28(44):11391–11400. PMCID: PMC2598739. Nout YS, Mihai G, Tovar CA, Schmallbrock P, Bresnahan JC, Beattie MS (2009) Hypertonic saline attenuates cord swelling and edema in experimental spinal cord injury: A study utilizing magnetic resonance imaging. Critical Care Med, 37 (7), DOI: 10.1097/CCM.0b013e3181a05d41.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Irvine K-A, Ferguson AR, Mitchell KC, Beattie SB, Beattie MS, Bresnahan JC. (2010) A novel method for assessing proximal and distal forelimb function in the rat: Irvine, Beatties and Bresnahan (IBB) Forelimb Scale. Journal of Visualized Experiments. Sun, F, McTigue, D., Lin, CG, Shan, X, Tovar, CA, Bresnahan, JC, Beattie, MS (2010) Effects of axon degeneration on oligodendrocyte lineage cells: Dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. Glia, 58: 1304-1319 . Beattie MS, Ferguson AR, Bresnahan JC (2010) AMPA-receptor trafficking and injury-induced cell death. Eur. J. Neurosci., 32: 290-297. Kwon BK, Okon E, Guest JD, Beattie MS, Bresnahan JC, Tsai E, Magnuson DK, Popovich PG, Saunders N, Whittemore SR, Oudega M, Weaver LC, Fehlings MG, Tetzlaff W (2010) A grading system to objectively evaluate the strength of preclinical data of acute neuroprotective therapies for clinical translation in spinal cord Injury, J. Neurotrauma, May 10, 2010 (ahead of print). Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH (2010) Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience, 13 (12): 1505- 1510. Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble M, Beattie MS, Bresnahan JC. (2011) Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in Rats. Exp. Neurol. 227:159-171. PMC3018678. Bresnahan JC, Beattie MS (2011) Spinal cord injury: Taking a detour to recovery. Eur J Neurosci, 34:8;1254- 1255. DOI: 10.1111/j.1460-9568.2011.07913.x Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosensweig ES, Brock JH, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. (2012) Methods for functional assessment after C7 spinal cord hemisection in the Rhesus monkey. Neurorehabilitation and Neural Repair, 26,6:556-569. Published online Feb 13, 2012; DOI: 10.1177/1545968311421934 Gensel J, Tovar CA, Bresnahan JC, Beattie MS (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. PLoS One, 7,3:e33519-e Nout YS, Beattie MS, Bresnahan JC (2012) Severity of locomotor and cardiovascular derangements after experimental high thoracic spinal cord injury is anesthesia dependent. J Neurotrauma, 29: 990-999. Stuck E, Christensen RN, Huie JR,Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR (2012) Tumor necrosis factor alpha (TNFa) mediates GABA-A receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural Plasticity, article 261345, doi 10.1155/2012/261345. Sorani MD, Beattie MS, Bresnahan JC (2012) A quantitative analysis of clinical trial designs in spinal cord injury based on ICCP guidelines. J Neurotrauma, 29:1736-1746. DOI: 10.1089/neu.2011.2162 Huie JR, Baumbauer K, Lee K, Beattie MS, Bresnahan JC, Ferguson AR, Grau J (2012) Glial tumor necrosis factor alpha (TNF alpha) generates metaplastic inhibition of spinal learning. PLoS ONE, 7(6) e-39751 June 20, 2012. Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecher S, Zdunowski S, Nielson J, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH (2012) Animal models of neurologic disorders: A non-human primate model of spinal cord injury. NeuroRX, 9:380-392. Downing TJ, Wang A, Yan Z, Lee AL, Nout YS, Beattie MS, Bresnahan JC, Farer DL, Li S. (2012) Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. Journal of Controlled Release,161,3:910-17. Ferguson AR, Irvine K-A, Gensel JC, Nielson JL, Lin, A, Ly J, Segal MR, Ratan RR, Bresnahan JC, Beattie MS (2013). Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PLoS One, 8(3):e59712, March 27, 2013. Inoue, T, Lin A, Ma X, McKenna SL, Creasy GH, Manley GT, Ferguson AR, Bresnahan JC, Beattie MS. (2013) Combined SCI and TBI: Recovery of forelimb function after unilateral cervical spinal cord inury (SCI) is

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): retarded by contralateral and enhanced by ipsilateral cortical contusion traumatic brain injury (TBI). Experimental Neurology, 238: 136-147.

Other Support ACTIVE

R01 NS038079 (Co-PIs: Beattie/Bresnahan) 08/15/2011 – 03/31/2016 2.4 calendar mos. NIH/NINDS $229,041 TDC Mechanisms Of Secondary Damage After Spinal Cord Injury This work is aimed at understanding the biology of the expanding lesion and the mechanisms of cell death and repair that might be modified or enhanced to promote regeneration and recovery after spinal cord injury in a rat contusion model. Role: Co-Principal Investigator

R-01 NS042291 (Tuszynski/Bresnahan) 08/15/2011 – 03/31/2016 1.44 calendar mos. NIH/NINDS $65,929 TDC Plasticity and Regeneration in the Primate Spinal Cord The aims of this project are to examine the effects of cortical stimulation on plasticity and recovery of function after hemisection injury to the cervical spinal cord of the rhesus monkey. Role: Subcontract Principal Investigator

Craig H. Neilsen Foundation (Bresnahan) 07/01/2013-06/30/2016 1.08 calendar mos. $190,930 TDC Neuroprotection in a Contusion SCI Model in the NHP Our overall objective is to provide a translational platform for the evaluation of therapies for cervical spinal cord injury (SCI) that moves promising preclinical findings in rodents to the nonhuman primate (NHP), and ultimately to human trials.

DOD US Army Med. Res. Acq. Activity (Beattie) 09/01/2013-08/31/2016 0.84 calendar mos. $250,000 TDC Effects of Early Acute Care on Autonomic Outcomes in SCI:Bedside to Bench and Back The objective of this proposal is to understand the role of cardiovascular variables in the recovery process after acute spinal cord injury using clinical data to model the range of variations, then testing methods to determine how to achieve the best outcome. Role: Co-Investigator

R01 NS069537 (Ferguson) 03/01/2010 – 02/28/2014 0.40 calendar mos. NIH $242,800 TDC Metaplasticity And Recovery After Spinal Cord Injury: Cellular Mechanisms The proposed project explores cellular mechanisms that regulate a form of spinal cord learning that is thought to contribute to recovery of function after SCI. Role: Co-Investigator

R01 NS067092-01A1 (Ferguson) 05/01/2010 – 04/30/2015 0.60 calendar NIH $214,375 Bioinformatics for translational spinal cord injury research This represents a new direction for the field of experimental SCI and we expect this approach to help define outcome metrics that are comparable across species, facilitating translational SCI research. Role: Co-Investigator

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person.

NAME POSITION TITLE Nancy Nies Byl Professor Emeritus eRA COMMONS USER NAME (credential, e.g., agency login) Byln EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, San Francisco BS 1963 Physical Therapy University of California, Berkeley MPH 1968 Public Health University of California Berkeley and San PhD 1985 Education Francisco State University ______

A. Personal Statement I have been a practicing clinician in physical therapy for 50 years. In this period of time, I pursued advanced education to provide a foundation to provide leadership in education and research. While I have assumed leadership in academic development, administration and both basic and clinical research, I consistently maintained my clinical skills as a physical therapist through patient care in our UCSF Faculty Practice. Currently I provide consultations, direct patient care, oversee group classes of intensive exercise for patients with PD and carry out clinical research studies in the PT Health and Wellness Center at Mission Bay. Over the last 3 decades I have transitioned from animal based models of wound healing and overuse syndromes to clinical research studying the etiology of focal dystonia to applications of rehabilitation technology and learning based intervention strategies to facilitate recovery of function in patients post CVA, PD, brain trauma and chronic pain. Working with collaborators in neuroscience, we designed an animal model to study the etiology of focal hand dystonia. Our findings created a paradigm shift in the understanding of focal dystonia as neural maladaptation of sensory and motor processing versus psychopathology. Based on these findings we developed a learning based sensorimotor training program as a critical factor in recovery for patients post neurological dystunction. I work collaboratively with researchers in the Departments of Radiology and Neurology to try to understand the biomarkers associated with patients who recover substantially post stroke or post dystonia and those who do not as well as design and test the effectiveness of learning based training.

B. Honors and Positions Honors 1959 Deans List 1960 Deans List 1961 Deans List 1962 Deans List 1968 Honor Society, School of Public Health, University of California, Berkeley 1982 Honors, Qualifying Examination for Candidacy

1 1988 University of California, San Francisco Faculty Development Award 1992 Outstanding Research Award, California Chapter, American Physical Therapy Association 1993 Charles Magistro Outstanding Service Award, California American Physical Therapy Assn 2000 Catherine Worthingham Fellow, APTA 2000 Royce B Noland Award of Merit, CAPTA 2001 Outstanding Graduate Alumni, San Francisco State University 2004 Lucy Blair Service Award. American Physical Therapy Association 2005 Outstanding Research Presentation, CAPTA Annual Meeting Research Special Interest Group 2006 Keynote Speaker, Smart Prosthetics, Academy of Science, Keck Foundation 2007 Outstanding Lecturer, Medical Students, UCSF School of Medicine 2008 Keynote speaker, Brain Conference on Learning, Jensen Learning Corporation 2008 Keynote speaker: Research Day USC, School of Dentistry, Case Western, SOM, Div Rehab 2009 Keynote speaker, White coat ceremony, Samuel Merritt University 2009 Keynote speaker, Research Day UCSF/SFSU 2010 Special Issue Editor, Journal of Hand Therapy, Focal Hand Dystonia 2013 Keynote speaker, White Coat Ceremony, UCSF/SFSU 2013 Anne Shumway Cook Research Lecturer, APTA, Section on Neurology 2013 Marian Rogers Special Lecturer, Rancho Los Amigos, Downey, CA

Positions: Present Professor and Chair Emeritus Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, School of Medicine Professor, Emeritus SFSU Graduate Program in Physical Therapy, Professor, Emeritus Joint UCSF/SFSU Bioengineering Physical Therapist Consultant, UCSF, Peter Ostwald Health Program for Performing Artists Professor, Emeritus PT Health and Wellness Center, Bakar Fitness Center, Rukker Community Center, Campus Life Services, Mission Bay

Past Positions at UCSF

1968-69 Acting Director, Health Services Research, Division of Ambulatory and Community Medicine, Department of Medicine

1971-84 Deans Advisory Committee, Curriculum in Physical Therapy

1972-79 Lecturer, Division of Ambulatory and Community Medicine, Department of Medicine, School of Medicine

1975-79 Physical Therapy Consultant, General Medical Clinics, Division of Ambulatory and Community Medicine, Department of Medicine, School of Medicine

1974-79 Coordinator, Interdisciplinary Teaching Program, (grant) Division of Ambulatory and Community Medicine, Department of Medicine, School of Medicine

1975-79 Evaluator, Primary Care Teaching Program (grant), Division of Ambulatory and Community Medicine, Department of Medicine, School of Medicine

2

1974-79 Clinical Preceptor, Curriculum in Physical Therapy, School of Medicine

1972-2006 Lecturer, Department of Family and Community Medicine

1984-85 Lecturer, Curriculum in Physical Therapy, School of Medicine

1985-86 Assistant Professor in Residence, Acting Director, Curriculum in Physical Therapy

1986-89 Assistant Professor, Director, Curriculum in Physical Therapy

1989-97 Associate Professor, Director UCSF Graduate Program in Physical Therapy

1989-1998 Administrative Director, Center for Human Performance Testing, Education and Research, Graduate Program in Physical Therapy, School of Medicine

1989-2009 Administrative Coordinator, UCSF Peter Ostwald Health Program for Performing Artists, School of Medicine

1989- 2009 Physical therapy faculty member and clinician, Faculty Practice, Department of Physical Therapy and Rehabilitation Science)

1989- 2007 Co Director UCSF/SFSU Graduate Program in Physical Therapy

1997- 1999 Professor, Director, UCSF Graduate Program in Physical Therapy

1999-2000 Professor, Interim Chair, UCSF Department of Physical Therapy and Rehabilitation Science, School of Medicine

2000-2007 Professor and Chair, Department of Physical Therapy and Rehabilitation Science, School of Medicine, University of California San Francisco

2007-2008 Professor, Department of Physical Therapy and Rehabilitation Science, School of Medicine, University of California, San Francisco

2007-2008 Director/Coordinator PT Health and Wellness Center, Bakar Fitness Center, Rukker Community Center, Mission Bay

2008-present Professor Emeritus, PT Health and Wellness Center Bakar Fitness center

PROFESSIONAL LICENSURE

9/63-present Registered Physical Therapist; State of California, Board of Medical Quality Assurance, Physical Therapy Examining Committee License 479

Professional Memberships Member American Physical Therapy Association

3 Member of the California Physical Therapy Association Member of the American Society of Hand Therapy Member of the Movement Disorders Society Member of the Society for Neuroscience

Editorial Board/Reviewer

J of Physical Therapy Education, reviewer 1990-present J of Physical Therapy Education: Editorial Board 2000-2007 Journal of Isokinetics and Exercise, Editorial Board 1990-present Journal of Orthopedics and Sports Physical Therapy, Reviewer 1990-present Physical Therapy, reviewer 1993-present PT Talk: Newsletter to Insurance Industry 1993-present J of Clinical Ultrasound, invited reviewer 1994-present Perceptual Motor Skills, invited reviewer 1995-present Internal J of Occupational Medicine, guest reviewer 1995-present J of Investigative Dermatology, guest reviewer 1998-present J of Hand Therapy, reviewer 1995-present J of Hand Therapy, Editorial Board 1998-present J of Hand Therapy, Speciall Editor 2008-present Neurology Guest reviewer 2000-present Muscle and Nerve; Guest reviewer 2001-present Annals of Neurology, Guest reviewer 2001-present Movement Disorders Guest reviewer 2001-present Archives of Physical Medicine and Rehabilitation Guest Reviewer 2004-present Lancet, Guest Reviewer 2003-present Neural Repair and Neural Plasticity guest reviewer 2003-present Stroke Guest reviewer 2004-present J of Neurophysiology Guest Reviewer 2004-present Neuroscience Letters- Guest Reviewer 2004-present J of Physical Medicine Guest Reviewer 2007-present J of Neurophysiology Guest Reviewer 2006-present Brain, Guest Reviewer 2009-present Clinical Rehabilitation, Guest Reviewer 2009-present Journal of Neurophysiology, Guest Reviewer 2009-present

PUBLICATIONS

1. Howard J and Byl N. Pitfalls in interdisciplinary teaching. Journal of Medical Education, 46 (9) : 772-78l, l97l

2. Brodsky C. Byl N. The concern about work in the practice of psychiatry. Community Hospitals and Psychiatry, 27 (2), 13-23, l976

3. Byl N and Clever L. Stable chronic disease: a behavioral model. Journal of the American Geriatric Society, XVV (7):408-414, l977

4 4. Byl N. and Sykes B.The approach to work/health problems in a primary care setting. Community Health, 9 (2): 149-158, l978

5. Byl N.Teaching rehabilitation within primary care setting. Archives of Physical Medicine and Rehabilitation, 60 (5): 230-236, l979

6. Dienst, R and Byl N. Evaluation of an Educational Program in Health Care Teams. Journal of Community Health 6 (4). 282-298, l981

7. Byl N and Gaylord-Ross R. Projecting the need for physical therapy in a pediatric population: a study polling the opinion of experts. Totline 11(2). 8-13 , l985

8. Byl N, Richards S and Asturias J. Intrarater and interater reliability of strength measurements of the biceps and deltoid using a hand held dynamometer. Journal of Orthopaedic and Sports Physical Therapy. 9 (12): 399-405, l988

9. Byl ,N. Prescreening admissions criteria and academic success in baccalaureate-certificate program in physical therapy. Journal of Physical Therapy Education, Spring: 13-17, l988

10. Byl N, Byl F, & Rosenthal J: The interaction of spatial perception, vestibular function and exercise in young school age males with learning disabilities. Perceptual and Motor Skills, 68:727-738, l989

11. Byl, N, Radtka S, Allen J. Physical Therapy Education in Transition: Advising Students. The Advisor, 9: 17-21, 1989

12. Byl N, Sinnott P: Variations in balance and body sway in middle aged adults: subjects with healthy backs compared to subjects with low back dysfunction. Spine, 16: 325-330, 1991

13. Friedlander, A, Block Jon, Byl N, Stubbs H, Sadowsky H S, Ganant H: Isokinetic limb and trunk muscle performance testing: short term reproducibility. J Orthopedic and Sports Physical Therapy. 14: 220-224, 1991

14. Byl, N. Incorporating movement awareness into muisicians’ lives. Strings. Nov/Dec: 53-57, 1990

15. Byl, N, Wells, L, Grady, D, Friedlander, A, Sadowsky, S. Consistency of repeated isokinetic testing: effect of different examiners, sites and protocols, J of Isokinetics and Exercise, 1: 122-130, 1991

16. Grady, D, Halloran, B, Cummings, S, Leveille, S, Wells, L, Black, D, Byl, N. 1, 25 Dihydrroxyvitamin D3 and Muscle Strangth in the Elderly: A Randomized controlled trial. J of Clinical Endocrinology and metabolism, 73: 1111-17, 1991

17. Byl, N, McKenzie, A, West, J, Whitney, J, Hunt TK. Low Dose Ultrasound Effects on Wound Healing: A Controlled Study with Yucatan Pigs. Arch Phy Med and Rehab, 73: 656- 664, l992

5

18. Byl, Nancy. Spatial Orientation to gravity and implications for balance training. Orthopaedic Physical Therapy. Clinics of North America, l (2):207-242, l992

19. Sullivan, EA, Radtka, S, Byl NN. Measurement of postural control in normal children. Network :May, 3-7, 1992

20. Byl N, McKenzie, A, West J, Stern, R, Longacker, M. Amniotic Fluid Modulates Wound Healing. European J of Rehabilitation Medicine, 2:184-190, l993

21. Byl, N, Gray, J. Complex Sensory Integrative Balance Reactions: Adolescents with Idiopathic Scoliosis and Normal Adolescents. Clinical Orthopedics and Related Research 11: 215-227, 1993

22. Byl N, McKenzie A, Longacher M Stern R, Hunt TK: HA modulates scar formation: Three week follow up, European J of Rehabilitation Medicine, 3: 10-15, 1993

23. Byl, N, Sadowsky S. Intersite Reliability of repeated isokinetic measurements: Cybex Back Systems including trunk rotation, trunk extension-flexion, and lifttask. Isokinetics and Exercise.3: 1-9, 1993

24. Harris, S, Takeguchi D, Byl N. The correlation of gain in knee strength and lifting. Isokinetics and Related Research, 3: 181-187, 1993

25. Byl, N, Arriaga R. Physical therapy and the injured musician. Physical Therapy Management. 10: 62-68, l993

26. Byl N, Hutchins B. California’s 1993 Legislative Reform for Workers’ Compenation. Newsletter, CAPTA Dec, 9-14, l993

27. Byl, N, McKenzie, A, Wong, T, West, J, Hunt, TK, Wong, T. Incisional wound healing: A controlled study of high and low dose ultrasound. J of Orthop and Sports PT, 18: 619-628, 1994

28. Byl, N, McKenzie, A, Wong, T, Halliday, B. Effects of Corticosteroids and phonophoresis: A controlled pilot study. J of Orthop and Sports PT, 18: 590-600, 1994

29. Byl N, McKenzie A, West, J, Whitney J, Hunt T, Hopf, H, Scheuenstuhl, H. Pulsed microamperage stimulation: A controlled study of healing of surgically induced wounds in Yucatan Pigs. Physical Therapy 74: 201-218

30: Ostwald P, Baron,B,Byl, N.Wilson,F.Performing Arts Medicine.West J of Med 1994:160: 48-52

31. Byl, N, Arriaga R. Treating the injured musician. PT Magazine. October: 62-65, 1993

6 32. Byl, N. Ultrasound as an Enhancer of Topically Applied Drugs, Phys Ther 75: 539-553, 1995

33. Friedlander, A, Genant H, Sadowsky, S, Byl N. Cluer, CC. A Two Year Program of Aerobics and Weight Training Enhances Bone Mineral Density of Young Women. J of Bone and Mineral Research; 10: l995 574-585

34 Byl, N, Merzenich, M, Jenkins, W. A Primate Genesis Model of Focal Dstonia and Repetitive Strain Injury: I. Learning-Induced De-differentiation of the Representation of the Hand in the Primary Somatosensory Cortex in Adult Monkeys, Neurology. 1996; 47: 508-520

35. Byl, N, Wilson, F, Merzenich, M, Melnick, M, Scott, P, Oakes, A, McKenzie, A. Sensory dysfunction associated with repetitive strain injuries of tendinitis and focal hand dystonia: A comparative study. J of Orthopaedic and Sports Physical Therapy, l996, 23: 234-244

36. Byl, N, Hamati, D. McKenzie, A, Melnick, M,Wilson, F. The Sensory consequences of repetitive strain injury in musicians: Focal dystonia of the hand; J of Back and Musculoskel Rehab . 1996; 7: 27-39

37. Ochs, C, Byl, N, Shoet, J. The symptomatology of Myasthenia Gravis. Alabama Medical Journal, 1998 12: 124-31

38. Byl, N, Holland S, Jurek, A, Hu S. Vibration and complex balance responses in patients with idiopathic scoliosis, J of Orthopedics and Sports Physical Therapy.1997, 26:60-68

39. Byl N, Toulouse L, Sitton, P. The directional effect of ultrasound movement on the orientation of fibroblasts. European J of Rehabilitation 1996; 6: 180-184

40. Fung, S, Byl, N, Melnick, M: Reliability and sensitivity of a new functional evaluation tool, European Journal of Rehabilitation. 1996: 7; 154-187

41. Jobst, E, Melnick, Byl, N, Dowling GA, Aminoff, M. Sensory Processing in Patients with Parkinsons Disease, Neurology 1997: 54: 450-454

42. Byl, N, Merzenich, M, Cheung, S, Bedenbaugh, P, Jenkins, WM, A primate genesis model of focal dystonia and repetitive strain injury: II. The effect of movement strategy on the de- differentiation of the hand representation in the primary somatosensory cortex in adult monkeys. Physical Therapy :1997: 77: 269-284

43. Byl, N, Melnick, M. The Neural consequences of repetition: clinical implications of a learning hypothesis. J of Hand Therapy. 1997 10: 160-174

44. Jobst, EE, Melnick, ME, Byl, NN, Dowlin, GA, Aminoff, M Sensory perception in Parkinson disease. Arch Neurol. 1997 Apr;54(4):450-4.

44. Byl, NN, Topp, K. Focal Hand Dystonia. Physical Therapy Case Report 1998: 2: 39-52

7 45. Nagarajan, SS, Blake DT, Wright BA, Byl N, Merzenich MM. Practice-related improvements in somatosensory interval discrimination are temporally specific but generalize across skin location, hemisphere, and modality. J of Neuroscience 1998: 18 (4), 1559-1570

46. Topp K, Byl N. Repetitive Strain Injury-Focal Hand Dystonia: An anatomic analysis, Movement Disorders, l999 14 (2); 295-206

47. Byl NN, Kohlase, W, Engel, G. Functional limitations immediately after cast immobilization and closed reduction of distal radius fractures J of Hand Therapy 1999 12:201- 211

48. Lenz, F, Byl, N. Reorganization in the cutaneous core of the human principal thalamic somatic sensory nucleus in patients with dystonia. J of Neurophysiology, 11:3204- 3212, 1999

49. Byl, N, McKenzie, A. Treatment effectiveness of patients with a history of repetitive hand use and focal hand dystonia: A planned prospective follow up study J of Hand Therapy, Oct-Dec 2000, 289-301

50. Byl, N, McKenzie, A, Newton, N, Nagarajan S. Differences in somatosensory hand organization: healthy flutist and flutist with Focal Hand Dystonia, J of Hand Therapy 2000, Oct Nov, 302-309

51. Byl, N, McKenzie, A, Nagarajan, SS. Effect of sensory discrimination training on structure and function in a musician with focal hand dystonia; A case study. Physical Therapy Case Reports, 3, 2000, 93-113.

52. Byl N, and Cheney, L. A new instrument for the measurement of stereognosis, in press. J of Hand Therapy 2002; Oct-Dec: 315-330

53 Sanger, T, Delgado, M, Gaebler-spira, D, Hallett, M, Mink, JW, and other task force members including Byl, N. Classification and definition of disorders causing hypertonia in childhood, in press, Developmental Medicine and Child Neurology, 2002

54. Byl, C, Puttlitz, C, Byl, N, Lotz, J, Topp, K. Strain in the median and ulnar nerves during upper extremity positioning. J of Hand Surgery 2002 27 1032-1040

55. Blake DT, Cheung S, Bedenbaugh, P, Nagarajan, S, Lamb, Byl, N,;M, Merzenich, M. Sensory representation abnormalities that parallel focal hand dystonia in a primate model, Somatosensory and Motor Research 2002 19; 347-357

56. Byl, N, McKenzie, AM Effect of sensory discrimination training on structure and function in patients with focal hand dystonia: A Case Series. 2003; Arch of Phys Med and Rehab; 84: 1505-1513

8 57. Byl N, Merzenich, M, Roberts, T, Nagarajan, S, McKenzie, AM. The correlation of clinical neuromusculoskeletal and central somatosensory parameters in patients with focal hand dystonia. Neural Plasticity 2002,9: 177-208

58. Byl N, Gerber, J, Mohamed O, Hanny M, Kotler, J, Smith, A, Tang, M, Abrams, G. Effectiveness of sensory and motor rehabilitation of the upper limb following the principles of neuroplasticity: Patients Stable Post Stroke, Neural Rehabilitation and Neural Repair 2003,17:176-191

59. McKenzie, A, Nagarajan, SS,Roberts, TPL, Merzenich,M, Byl, NN Somatosensory representation of the digits and clinical performance in patients with focal hand dystonia.. 2003; Ann of PM & R 82: 737-749

60. Byl, NN. What can we learn from animal models of focal hand dystonia Rev Neurol (Paris) 2003, 159: 1-17

61. Byl, NN. Focal hand dystonia may result from aberrant neuroplasticity Dystonia 4: Annals of Neurology. 2004; 94: 19-27

62. Whithall, J, Byl, NN Editorial Stroke Rehabilitation Research: Time to Answer more specific questions? Neural Rehabilitation and Neural Repair, 2004, 18: 3-11

63. Strata F, Coq, JO, Byl, N, Merzenich MM. Effects of sensorimotor restriction and anoxia on gait and motor cortex organization: implications for a rodent model of cerebral palsy. Neuroscience 2004 129:141-156

64. Mehling, WE, Hamel, KA, Acree, M, Byl, N, Hecht, FM. Randomized, controlled trial of breath therapy for patients with chronic low back pain. Alternative Therapies 2005; 11 : 44-52

65. Satyendra, L, Byl, N. Evidence Based Review of Achilles Tendonitis and the Effectiveness of Isokinetic Exercise, Isokinetics and Exercise, 2006, 14: 71-80

66. Byl, N. Aberrant Learning in Individuals who Perform Repetitive Skilled Hand Movements: Focal Hand Dystonia, Parts 1 and 2, J of Bodywork and Movement Therapies, 2006: 10: 227-247 and 248-252

67. Esteil, S, Byl N. An evidence-based review of magnetic resonance angiography for diagnosing arterial thoracic outlet syndrome. J Hand Therapy; 2006 Oct-Dec 19; 410-419

68. Wampler, M, Topp, K, Byl, N, Hamel, K, Rugo, H, Miaskowski, Quantitative and Clinical Description of Postural Instability in Women with Breast Cancer Treated with Taxane Chemotherapy” Archives of Physical Medicine and Rehabilitation, -2007

69. Byl N. Learning-based Animal Models: Task-specific Focal Hand Dystonia Special Issue Animal Models Used in the Study of Movement Disorders ILAR Journal,2007 48:411-431

9 70. Coq, O,, Strata, F, Russier, M, Safadi, FF, Merzenich, M, Byl, N, Barbe, M Impact of neonatal asphyxia and hind limb immobilization on musculoskeletal tissues and S2 map organization: Implications for Cerebral Palsy Accepted 10/2007, Experimental Neurology 2008 ;210,95-108

71. Byl N, Pitsch, E, Abrams, G. Effect of Intensity of rehabilitation on recovery in patients stable post stroke. Neural Rehabilitation and Neural Repair, 2008 22(5): 494-504

72 .Eisner ,MD, Iribarren, C, Yelin, EH, Sidney, S, Katz, PP, Ackerson, L, Lathon, P, Tolstykh, I, Omachi, T, Byl, N, Blanc,PD. Pulmonary function and the risk of functional limitation in COPD, American J of Epidemiol 2008; 167(9): 1090-101,

73. Eisner, MD, Blanc, PD, Yelin, EH, Signey, S, Katz, PP, Ackerson, L, Lathon, P, Tolstykh, I, Omachi, T, Byl, N, Iribarren, C. COPD as a systemic disease: impact on physical functional limitations. Am J Med 2008; 121(9): 789-96

74. Byl, N, Archer, E, McKenzie, A Effectiveness of learning based memory and sensorimotor training for focal hand dystonia: the benefit of PT supervision and compliance J of Hand Ther 2009; 22,183-197

75. McKenzie A, Goldman S, Barrano C, Shrine M, Wong T, Byl, N Differences in physical characteristics and response to rehabilitation for patients with hand dystonia: musicians” cramp compared to writers’ cramp. 2009 J of Hand 2009; 22, 172-181

76. Leighton, H, Webster, B, Byl, N, Nagajaran, S Neuroimaging and focal hand dystonia J of Hand Ther 2009; 22, 125-134

77. Byl, NN, Editorial, Focal hand dystonia: a historical perspective from a clinician scholar; J of Hand Ther 2009: 22.106-108

78. Lui, L, Byl N The Effect of Moderate Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis:An Evidence-Based Review J Neurol Phys Ther 2009; 33: 68-87 Review PMD 195569 16 JNPT 2009;33: 000–000)

79. Jacques,Olivier, Barr, Ann E., Strata, Fabrizzio, Russier,Michael, Kietrys, David M., Merzenich, Michael M., Byl, Nancy N., Barbe, Mary F.,Peripheral and central changes combine to induce motor behavioral deficits in a moderate repetition task, Experimental Neurology (2009), Experimental Neurology 220 (2009) 234–245,doi:10.1016/j.Exp Neurol.2009; 220: 234-45 Epub 2009 Aug 15.

80. Smoot, B, Wong L, Cooper B, Wanek L, Topp K, Byl N, Dodd M. Upper extremity impairments in women with or without lymphedema following breast cancer treatment. J Cancer Surviv 3010; 4: 167-78 Epub 2010 Apr 7

81. Eisner, MD , Iribarren, C, Blanc, PD, Yelin, EH, Ackerson L, Byl N, Omachi TA, Signey S, Katz PP Development of disability in chronic obstructive pulmonary disease beyond lung function. Thorax 2011; 66: 106-14 Epub3010 Nov 3

10 82. Gorman, S, Byl, N, Radtka, S Measurement Scale for Sitting Balance for Patients Acute Post Stroke, J of Neurology Reports 2010; 24; 150-160

83. Byl, N, Caguimbaga, J Dual Task Training un Aerobic Conditions for Patients with Parkinson’s Disease: The Use of an Air Distributed Body Weight Support System, Advance in PT 2010; 327; 7-12

84. Bae J, Kong K, Byl N, Tomizuka M. A mobile gait monitoring system for abnormal gait diagnosis and rehabilitation: a pilot study for Parkinson disease patients. J Biomech Eng 2011; 133: 041005

85. Kim H, Miller LM, Byl N, Abrams GM, Rosen J. Redundancy resolution of the human arm and an upper limb exoskeleton.IEEE Trans Biomed Eng. 2012 Jun;59(6):1770-9. Epub 2012 Apr 11

86. Byl N, Managing Focal Hand Dystonia, Current Opin Rheumatol, 2012; 24 (2):222-31

87. Dolberg R, Hinkley LB, Honma S, Zhu Z, Findlay AM, Byl NN, Nagarajan SS.Clin Neurophysiol. 2011 Dec;122(12):2441-51. Epub 2011 Jul 28. 21802357

88. Webster R, Hinkley L, Byl N, Nagarajan S Changes in sensory responses in focal hand dystonia Brain Mapping, 9-2012 accepted

89. Westlake, KP, Hinkley, LB, Bucci, M, Guggisberg, AG, Findlay, AM, Byl, N, Henry, RG, Nagarajan, SS. Resting State Alpha-band functional connectivity and recovery after stroke. Exp Neurology accepted 9-2012

90. Westlake, KP, Byl N. Translating science to clinical practice: Neural plasticity and neuro- rehabilitation J of Hand Therapy, Accepted 10-2012

91. Simkins M, Fedulow I, Byl N, Hyunchu K, Rosen J. Robotic Rehabilitation Game Design for Chronic Stroke. Games for Health Journal. Accepted Nov 2012

92. Hinkley L, Byl N, Nagarajan S Complex-value coherence mapping reveals novel abnormal resting- state functional connectivity networks in task-specific focal hand dystonia, Frontiers in Neurology accepted 3/2-13

93. Byl N, Abrams G, Nagarajan S, Simpkins M, Rosen J. Effectiveness of task specific repetitive training guided by a physical therapist or a dynamic orthosis, J Hand Therapy, accepted 9/2013

Book Chapters

1. Byl, N , Kloth L, Enwemeka C, Zellerback L. The Skin in Physical Therapy for the Experienced Physical Therapy Clinician, Saunders Publishing Company, First Edition, l994

2. Byl N, Hopf H. Role of Oxygen in Wound Healing: Chapter 16 in Kloth L, McCulloch J. Alternatives in Management in Wound Healing, Saunders Publishing Company, NY, Second Edition, 1994

11 3. Hoagland, F and Byl, N. Chapter 12: Musculoskeletal Injuries; . LaDoe, Joe, MD, Occupational Medicine 1995, 1998

4. Byl, N, Cameron M, Zellerbach, L, Pfalzer, C. The Integumentary System, Chapter 24 Anatomical and Physiological Considerations. Chapter 25 Integumentary System Screening, Examination, and Assessment; Chapter 26 Systemic Issues and Skin Conditions: Wound Healing, Oxygen Percutaneous Drug Delivery, Burns and Desensitized Skin; Chapter 27, Treatment and prevention: Goals and Objectives in Myers, Rose Sgarlat (Ed). Saunders Manual of Physical Therapy Practice, 1999

5. Byl, N. Chapter: Electricity and Tissue Repair; Chapter Clinical Applications of Electrical Current and Wound Healing in Nelson, R, Currier, D (Eds) Clinical Electrotherapy, 3rd edition, Appleton and Lange, l998

6. Sussman, C, Byl, N. The Clinical applications of Electrical Current for Wound Healing, in Sussman, C. Editor, Wound Healing, Williams and Wilkins 1998, 2000

7. Byl, NN, Merzenich M. Focal Hand Dystonia, Chapter in Hunter, JM, Mackin,EJ, Callahan, AD. Rehabilitation of the Hand: Surgery and Therapy, Fifth Edition, 2001

8. Byl NN, Merzenich MM. Principles of Neuroplasticity , Chapter 16, Physiological Basis of Rehabilitation, 2000

9. Byl NN. Focal Hand Dystonia: Principles of Neuroplasticity Applied to Treatment, in On the Move, Dystonia Foundation, 2001

10. Byl, NN, Neuroplasticity Chapter 4, in Motor Control in Children, Patricia Montgomery (Ed) 2001

11. Umphred, DA, Byl, NN, Lazaro, RT, Roller, ML. Chapter 9 Interventions for Clients with movement Limitations, in Umphred Darcy, Neurological Rehabilitation, Fifth Edition, Mosby Elsevier, 1999, 2005; 2007,2009,2012 187-281

12. Byl K, Byl M, Byln, Umphred DA. Rehabilitation Robotics in Neurological Rehabilitation, in Umphred, DA, Burton G, Lazaro, RT, Roller, ML. Chapter 9 Interventions for Clients with movement Limitations, in Umphred Darcy, Neurological Rehabilitation, Sixth Edition, Mosby Elsevier, 2012

13. Byl NN Focal Dystonia: Conservative, Nonpharmacologic Treatment in WE MOVE, Dystonia Monograph, 2004, pp 1-29

14. Byl, NN and Priori,A. Focal hand dystonia and maladaptive plasticity: Implications for Intervention, Altenmueller, E (Ed) Proceedings from International Conference on Health Problems for Performing Artists, 2004

15. Byl NN. Behavioral basis of focal hand dystonia: Aberrant Learning in the somatosensory cortex. Ebner, F Behavioral Models of Movement Disorders, CRC publishing, 2005

12

16. Byl, NN, Focal Dystonia , Chapter 127 in Mackin, EJ, Callahan, AD, Skirven, TM, Schneider, LH, Osterman, AL Rehabilitation of the Hand and Upper Extremity, 2004, Mosby Publishers, Fifth Edition, 2053-2075 (revision 2009-10)

17. Blake, D, Byl ,N, Merzenich, M. The Owl Monkey model of focal dystonia. LeDoux, M (Eds) Animal Models of Movement Disorders, Lippincott Publishers, 2005

18. Byl, N, Barbe, M, Barr A. Repetitive Strain Injuries Chapter 22, in Zackaguski J (Ed) Evidence Based Practice and Musculoskeletal Injuries, FA Davis,, 2008

19. Byl, N and Priori, R. Chapter 19 The development of focal dystonia in musicians as a consequence of maladaptive plasticity: implications for intervention 293-308 in Altenmuller, E, Wiesendanger, M, Kesselring, J. (Eds) Music, Motor Control and the Brain, Oxford University Press, 12/2006

20. Jacobson T and Byl N Dystonia Chapter 23, in Sullivan, Katherine, Neurologic Physical Therapy and Measurement of Neurologic Function FA DAVIS 2012

Research Grant Support:

Recent Funded Research

NIH RO1 Sensorimotor Rehabilitation and Focal Hand Dystonia PI Srikantan Nagarajan Co-PI Nancy Byl (20%) 2009-2012

NIH R01 Brain Recovery and Reorganization Post Stroke PI Sirkantan Nagarajan; CoPI Kelly Westlake Byl Consultant 10% 2009- 2012

CITRESS PI Jacob Rosen, Byl N, Abrams G 2010-2012 Upper Limb Rehabilitation with Robotic Exoskeleton: Bilateral, Unilateral and Usual PT

NSF Kyoungchul, Kong and T Kumicuchi, Co PI 2009-2014 Networked Rehabilitation System Byl Consultant 5% time

Ekso Bionics Byl N and Riley A 2012-2013 CVA and Integration of a Robotic Exoskeleton for Ambulation

Funded and Completed Research

Tibion Byl N Effectiveness of the Bionic Leg 100 : Case Series 2010

Ames Laboratory 2007-2010 PI Paul Cordo, PhD Subacute Stroke Program: Robotic training

13 Nancy Byl, PhD, PT PI UCSF Site and Evaluator 5% time

Alterg PI N Byl PI 2009-2010 Dual Task and Aerobic Training: Patients with PD Equipment and AA

Dystonia Foundation PI Leighton Hinkley 2008-2010 Neuroimaging and Connectivity: Focal Hand Dystonia Byl, N Mentor

Stroke Foundation PI Westlake Kelly 2008-2010 Neuroimaging and brain reorganization post stroke Byl, N Mentor

Canadian Foundation for Rehabilitation PI Westlake K 2008-2010 Fellowship Neuroimaging and brain reorganizationPost stroke Byl, N consultant

NIH RO1 PI Dr. Christine Miakowski Effect of Flying on Lymphadema in Patients With Breast Cancer Byl Consultant (15%) 2006-2009

VA Gary Abrams, MD PI 2004-2005 Stroke Rehabilitation: New Imaging Techniques Byl Consultant and evaluator 12 %

Northstar Gary Abrams, MD PI 2005-2007 Randomized Clinical Trial: Electrical Stimulation and Stroke Rehab Byl Consultant and evaluator (15%)

REAC Kate Hamel, PhD (PI) Nancy Byl, co-PI Shared Equipment Grant 2004-2005

Lee Family Foundation Nancy Byl, Erica Pitsch, Co PI Stroke Rehabilitation: Body Weight Supported Gait Training 2004-2006 Byl Evaluator 5% time

NIH RO1 Dr. Mark Eisner, PI Longitudinal Study of Disability in Patients with COPD 2004-2009 Byl Consultant 5% time

NS 3483E Michael Merzenich, PhD (PI) 1992-2000 Neuroplasticity, Byl Consultant and provided financial support for primate research on focal dystonia ( Keck Center for Neuroscience)

14 NINDS-NS 10414 Steve Lisbrger, PhD (PI) 1995-2006 Neuroplaticity Byl Consultant

NIH Grant KO1 Phil Starr, MD (PI) 1999-2004 NINDS Training Grant, Career Research Award Pallidal Physiology of Human and Primate Dystonia Byl Consultant

PI Bart Kylstra 2005-2007 NIH SBIR (Small Business Innovation Research) Phase II grant 2 R44 HD043567-02,"Manual Wheelchair Utilizing Single Lever for Propulsion" Byl Consultant 2% time

PI Susan Brown, PhD 2005- 2007 NIH Department of Education Sensory Training for Adults with Cerebral Palsy Byl Consultant ; equipment supplied for UCSF to become a site

NIH RO1 B. Halloran, MD (PI) 1994-1996 Effect of Vitamin D on Strength in the Elderly Byl Consultant

NIH RO1 H.Genant, MD (PI) 1995-1997 Effect of Exercise and Calcium on Bone Mineralization and Strength Byl Consultant

NIH RO1 TK Hunt, PI 1991-93 Wound Healing and Oxygen Byl Research Associate

NIH Training Grant Robert Crede, MD (PI Interdisciplinary Teaching in the Health Sci 1971-1979 Byl Project Coordinator

NIH Training Grant Robert Crede, MD (PI) 1975-1979 Teaching Rehabilitation in Primary Care Byl Co PI and Curriculum Coordinator

NIH Training Grant Robert Crede, MD (PI 1971-1976 Residency in Primary Care: Pediatrics and Internal Medicine Byl Co PI and Evaluator

Total Control Systems NightWrest Splints 2007-2008

15 PI N Byl Use of NightWrest Splints for RSI Supply splints and support for research assistant

UCSF Mt Zion Endowment 2008-2010 Nancy Byl PI Multidisciplinary Balance Clinic

REAC Gary Abrams , MD and Nancy Byl co-PI’s Stroke Rehabilitation and BWSTT 2002-2003

REAC Nancy Byl PhD, PT, (PI) 2001 School of Medicine, UCSF Shared Equipment Grant

REAC Nancy Byl PhD, PT, (PI) 1997 School of Medicine, UCSF Primate studies : Etiology of FHD

Academic Senate Nancy Byl, PhD, PT (PI) 1994, 1996 Neuroplasticity changes in the sensorimotor cortex with repetitive overuse

CAL PT Fund Smith, MSPT (student PI) 2000 Nancy Byl, Faculty PI Effectiveness of neuroplasticity and sensorimotor training for patients with CVA

Roalia Ulloa, MSPT (Student PI) 1999 Nancy Byl and Kimberly Topp, Faculty mentors Neurovascular Entrapment: Effects of Progressive Stretch

Nancy Byl PhD, PT, (PI) Visual imagery and bone healing l997

Bonnie Brill ( PI) 1995 Magnetic imaging of the carpal tunnel with different splints

Nancy Byl PhD, PT, (PI) 1994 Use of the Clavinova for Motor Retraining

16 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Sibel Demir-Deviren, MD Associate Clinical Professor eRA COMMONS USER NAME (credential, e.g., agency login) SDEVIREN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Hacettepe University, Ankara, Turkey M.D. 07/93 Medicine

Ankara Education and Research Hospital, Physical Medicine & Ankara, Turkey Resident 07/97 Rehabilitation

Ankara Education and Research Hospital, Physical Medicine & Ankara, Turkey Post Graduate 07/99 Rehabilitation

University of California, San Francisco Post Graduate 07/02 Spinal Disorders

A. Personal Statement It has been known for decades that the disease processes associated with chronic low back pain are marked by altered spine kinematics. I have been trying to establish quantified descriptions of physiologic and pathologic spinal kinematics and demonstrate how these are influenced by disc and facet joint degeneration and paraspinal muscles as well as to define a treatment-focused functional grading scheme that can tailor treatment interventions with the potential improvement in patients’ outcomes. Our long-term goal from this study is to develop improved diagnostic classification systems that guide patient-specific treatment decisions to help avoid unnecessary spine surgeries so as to improve outcomes and reduce cost. My second research project is about Modic I degenerative disc disease (DDD). DDD is the most common cause of LBP, accounting for 39% of its incidence. As a result, estimates suggest there are average 4 million adults in the US with DDD-related LBP that failed conservative management and await therapeutic intervention, of which there are few options beyond spinal fusion and disc replacement. The success rate of surgeries for DDD has been reported as 41–57%, with early complication rate of 16% and reoperation rate of 5-11%. A major obstacle for the development of new therapeutic interventions and diagnostic modalities is uncertainty regarding why some degenerated disc hurt, since most of adults have degenerated disc that are asymptomatic. In fact, disc degeneration is normal in humans, the prevalence of which increases with age from 6% in those under 20, to 79% in those over 60. The etiologic factors that distinguish silent from symptomatic or physiologic from pathologic, degeneration are unclear. We theorize that some degenerated discs hurt because tissue microdamage at the disc/vertebra interface allows anaerobic bacteria to invade into the avascular disc and induce an inflammatory response at the endplate and outer annulus. Because of low virulence of microorganism, the patients present a chronic inflammatory response with accompanying symptoms without having clinical presentation of an infection. If this hypothesis is proven true, the course of diagnosis and treatment of this very prevalent condition could be significantly changed, with a potential improvement in patient outcomes. As an Associate Professor of Orthopaedic Surgery at University of California, San Francisco, Spine Center, I have treated more than 13,000 patients with spinal disorders and performed more than 10,000 fluoroscopy guided spine injections. Regularly following up all my patients after treatments including physical therapy with exercise programs, medications, and spine injections has helped me to develop anecdotal experience to distinguish between patients who would benefit from improving muscle function versus surgical interventions. Even though we are a tertiary center for the treatment of spinal disorders, 76% of our patients show improvement with non-surgical treatments. As a physiatrist, my primary goal is to help my patients to achieve maximum functionality of the musculoskeletal system. I would more than happy to contribute creation of a preeminent center of learning and discovery in rehabilitation science at the doctoral level and share my extensive clinical and research experience with the doctoral students.

B. Positions and Honors

Positions and Employment 1997-1999 Clinician, Physical Medicine and Rehabilitation Specialist, Ankara State Hospital, Ministry of Health, Ankara, Turkey 1997-1999 Chief, Pulmonary and Cardiovascular Rehabilitation Unit, Department of Physical Medicine and Rehabilitation, Ankara, Turkey Hospital, Ministry of Health, Ankara, Turkey 1999-2000 Research Associate, Department of Physiological Nursing, University of California at San Francisco 2001-2002 Specialist, Department of Physiological Nursing, University of California at San Francisco 1999-2002 Visiting Associate Researcher/Visiting Postdoctoral Scholar, Department of Orthopaedic Surgery University of California, San Francisco 2002-2010 Assistant Clinical Professor, Department of Orthopaedic Surgery, University of California, San Francisco 2010- Present Associate Clinical Professor, Department of Orthopaedic Surgery, University of California, San Francisco

Other Experience and Professional Memberships 1994-Present Turkish National Society of Physical Medicine and Rehabilitation 2002-Present American Academy of Physical Medicine and Rehabilitation 2009-Present North American Spine Society

Honors 2003 European PM&R Board Certified 2000 Chosen as one of (the most scientific) 25 papers among 5,000 papers in International Conference, American Thoracic Society 1993 Ranked in the 99th percentile in the country-wide residency examination 1986 Ranked in the 99th percentile in OSS and OYS (national student selection and placement examinations given annually in Turkey to 1,200,000 examinees)

C. Selected Peer-reviewed Publications

1. Hanelin J., Singh, S., Demir-Deviren S., Superior recess access of the lumbar facet joint. 2013 Submitted to Journal of Spinal Disorders & Techniques 2. Carrieri-Kohlman V., Nguyen H.Q., Donesky-Cuenco D., Demir-Deviren S., Neuhaus J., Stulbarg M.S., Impact of brief or extended exercise training on the benefit of a dyspnea self-management program in COPD. J Cardiopulm Rehabil. 2005 Sep-Oct;25(5):275-84. 3. Berven S., Deviren V., Demir-Deviren S., Hu S.S., Bradford D.S., Studies in the modified Scoliosis Research Society Outcomes Instrument in adults: validation, reliability, and discriminatory capacity. Spine. 2003 Sep 15;28(18):2164-9; discussion 2169. 4. Stulbarg M.S., Carrieri-Kohlman V., Demir-Deviren S., Nguyen H., Adams L., Tsang A.H., Duda J., Gold W.M., Paul S.M., Exercise training improves outcomes of a dyspnea self-management program. J Cardiopulmonary Rehab. 2002; 22: 109-121. 5. Bolgen-Cimen O., Demir-Deviren S., Yorgancioglu R., Cardiopulmonary exercise test response, pulmonary function test, maximum inspiratory and expiratory pressure and their correlations with clinical findings in patients with Rheumatoid Arthritis. J of Rheumatology. 2001; 20: 168-173. 6. Carrieri-Kohlman V., Gormley J., Eiser S., Demir-Deviren S., Nguyen H., Paul S.M., Stulbarg M.S., Dyspnea and the affective response during exercise training in chronic obstructive pulmonary disease. Nurs Res. 2001; 50: 136-146. 7. Demir-Deviren S., Koseoglu F., Ardicoglu O., Bolgen-Cimen O., Karabiyikoglu G., Yorgancioglu R., Exercise test response and effects of the pulmonary rehabilitation program on the ergospirometry test parameters and clinical findings in patients with Ankylosing Spondylitis. Physical Medicine. 1998; 1:1-8. 8. Koseoglu F., Ozel S., Demir-Deviren S., Karabiyikoglu G., Yorgancioglu R., Effects of the pulmonary rehabilitation program on pulmonary functions, cycle ergometry test parameters, exercise tolerance, and spinal mobility in patients with Ankylosing Spondylitis. Euro J Phy Med Rehab. 1998; 8: 67-70. 9. Aksoy M. A., Karaoglan B., Demir-Deviren S., Investigation of Chlamydia trochamatis Ig G and IgM antibodies in various cases of arthritis. Journal of Clinical Laboratory Research. 1997; 1: 17-22. 10. Koseoglu F., Inan L., Ozel S., Demir-Deviren S., Karabiyikoglu G., Yorgancioglu R., Atasoy T., Ozturk A., Effects of the pulmonary rehabilitation program on pulmonary function tests and exercise tolerance in patients with Parkinson's Disease. Functional Neurology. 1997; 12:319-325. 11. Gun F., Koseoglu F., Karaoglan B., Demir-Deviren S., Investigation of pulmonary function tests and exercise capacity in patients with scoliosis. Journal of Ege Physical Medicine and Rehabilitation. 1997; 3: 19-25.

D. Research Support

Completed Research Support

"The Minimal Clinically Important Difference for Degenerative Spinal Disorders: Finding the Threshold of Clinically Significant Change" North American Spine Society, 2006, $49,890. 1/1/2006 – 1/1/2008 Principal Investigator: Vedat Deviren, MD, Co-Investigators: Sigurd Berven, MD & Sibel Demir-Deviren, MD As we begin to utilize patient-based health status outcomes as a measure of the utility for a given intervention, it becomes important to differentiate between statistically and clinically significant changes in health status. Small differences in health-related quality of life or health related outcome measures may be statistically significant, yet clinically unimportant. The minimal clinically important difference (MCID) defines a threshold of change that is recognized by the patient as valuable and appreciable. The primary purpose of this project is to establish the minimal clinically important difference for the SF-36, SRS, and Oswestry Disability Index in patients undergoing treatment (surgical and non-surgical) for cervical and lumbar degenerative spinal disorders. Secondary aims of this study include: Comparing different methods of measuring the MCID and evaluating the effect of measurement method, prognosis, and diagnosis on the magnitude of the MCID.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person DO NOT EXCEED FOUR PAGES NAME POSITION TITLE Adam Ferguson, Ph.D. eRA COMMONS USER NAME Assistant Professor AFerguson EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Southwestern University, Georgetown, TX B.A. 05/1998 Psychology Texas A&M University, College Station, TX M.S. 12/2000 Psychology Texas A&M University, College Station, TX Ph.D. 05/2004 Psychology The Ohio State University, Columbus, OH Postdoc 05/2004-10/2006 Neuroscience University of California, San Francisco, CA Postdoc 11/2006-02/2007 Neurosurgery University of California, San Francisco, CA NIH Postdoc 03/2007-02/2010 Neuroscience/ Neurosurgery

A. Personal Statement

My laboratory focuses on spinal cord injury (SCI) and traumatic brain injury (TBI) research with support of the NIH/NINDS, DoD, VA and a variety of private foundations. My team consists of graduate student trainees from the UCSF doctorate of physical therapy training program, post-baccalaureate and postdoctoral students. In addition I serve as faculty on the UCSF-Biomedical Science Graduate program. My goal is to help train next- generation scientists to help integrate diverse outcome measures using bioinformatics approaches to provide a holistic complete understanding of complex interrelationships between behavioral, physiological, and morphological manifestations of recovery. I have the training necessary guide graduate students in their conceptual and technical education about biomedical research projects. With a PhD in psychology, I have significant formal training in multivariate statistics and serve as PI on an NIH R01 that specifically focuses on applying this statistical knowledge to complex datasets produced in bio-behavioral neuroscience research. In addition, I offer consultation on other technical elements biomedical research. My graduate work and 6 years of postdoctoral training focused on behavioral, cellular and molecular mechanisms of cell death and plasticity after neurotrauma, providing the background to understand the technical language of a variety of research projects. I also serve as PI on an NIH R01 that focuses on mechanisms of neurological metaplasticity and have experience with a variety of basic biological techniques including behavioral assessment, immunohistochemistry, microscopy, algorithmic image analysis, and biochemistry. This background allows me to understand nuances of data from diverse sources within biomedicine. I take pride in passing this knowledge along to trainees, successfully sponsoring two postdoctoral fellowships and sending post-baccalaureate students onto prestigious graduate and medical schools.

B. Positions and Honors

Positions and Employment 1995-1998 Research Assistant, Dept. of Psychology, Southwestern University, Texas. 1998-2004 Teaching Assistant, Instructor & Research Assistant, Dept. Psychology, Texas A&M University. 2004-2006 Postdoctoral Researcher, Dept. of Neuroscience, The Ohio State University. 2006-2012 Visiting Scholar, Dept. of Neuroscience, The Ohio State University. 2007-2010 Individual NIH NRSA Postdoctoral Fellow, University of California, San Francisco. 2010-present Assistant Professor, University of California, San Francisco.

Other Experience and Professional Memberships 1998-present Society for Neuroscience 2006-present American Association for the Advancement of Science 2006-present New York Academy of Sciences 2004-present National Neurotrauma Society 1998-2006 American Psychological Association, Division 6 2009 Chair, Society for Neuroscience Nanosymposium: “Spinal Cord Injury: Beyond Biology to Therapy” 2007-present Reviewer: Behavioral Neuroscience; Brain Research; European Journal of Neuroscience; Journal of Neuroscience; Journal of Neurotrauma; PLoS One 2012-present External advisory board for NIH common data elements project for spinal cord injury 2012-present Outside consultant NIH common data elements working group for preclinical traumatic brain injury 2012 Planning committee for NIH-funded workshop “Growth cones and axon regeneration: entering the age of informatics”

Honors Phi Kappa Phi Psi Chi Texas A&M University Thesis Minigrant, 2000 Texas A&M University Department of Psychology Travel award, 1999, 2000, 2001, 2003 Texas A&M University Faculty for Neuroscience Travel award, 1999, 2001, 2003 Society for Neuroscience Chapters/Eli Lilly Graduate Student Travel Award, 2002 Texas A&M University Assoc. of Former Students Distinguished Graduate Doctoral Research Award, 2004 Winner, OSU Medical Center Graduate and Postgraduate Research Day Poster competition, 2006 The Michael Goldberger Prize from the National Neurotrauma Society, 2007 Individual NIH National Research Service Award, 2007-2010 NIH Early Stage Investigator, 2010

C. Selected Peer-reviewed Publications (selected from 119 peer-reviewed papers and abstracts)

Most relevant to the current application 1. Rosenzweig, E.S., Courtine, G.C., Jindrich, D.L., Brock, J.H., Ferguson, A.R., Strand, S.S., Nout, Y.S., Roy, R.R., Miller, D., Beattie, M.S., Havton, L.A., Bresnahan, J.C., Edgerton, V.R., Tuszynski, M.H. (2010). Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience, 13, 1505-1510. [PMID: 2107642][PMCID: PMC3144760] 2. Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 2012 Jul-Aug; 26(6):556-69. PMID: 22331214 3. Ferguson, A. R., Hook, M.A., Garcia, G., Bresnahan, J. C., Beattie, M. S., & Grau, J. W. (2004). A simple post-hoc transformation that improves the metric properties of the BBB scale for rats with moderate tosevere spinal cord injury. Journal of Neurotrauma, 21, 1601-1613. [PMID: 15684652] 4. Ferguson, A.R., Stuck, E.D., Nielson, J.L. (2011) Syndromics: A bioinformatics approach for neurotrauma research. Translational Stroke Research, 2, 438-454. [PMID:22207883][Free PMC article] 5. Ferguson, A.R., Irvine, K-A., Gensel, J.C., Nielson, J.L., Lin, A., Ly, J., Segal, M.R., Ratan, R.R., Bresnahan, J.C., Beattie, M.S. (2013). Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PLoS One. doi:10.1371/journal.pone.0059712 [PubMed-In process][Free PMC Article]

Additional recent publications of importance to the field (in chronological order) 1. Crown, E. D., Ferguson, A. R., Joynes, R. L., & Grau, J. W. (2002). Instrumental learning within the spinal cord: II. Evidence for central mediation. Physiology and Behavior, 77, 259-267. [PMID:12419402] 2. Ferguson, A. R., Washburn, S. N., Crown, E. D., Grau, J. W. (2003). GABAA receptor activation is involved in non-contingent shock inhibition of instrumental conditioning in spinal rats. Behavioral Neuroscience, 117, 799-812. [PMID:12931964] 3. Ferguson, A. R., Crown, E. D., & Grau, J. W. (2006). Nociceptive plasticity inhibits adaptive learning in the spinal cord. Neuroscience, 141, 421-431. [PMID:16678969] 4. Bigbee, A.J., Crown, E.D., Ferguson, A.R., Roy, R.R., Tillakaratne, N.J.K., Grau, J.W., & Edgerton, V.R. (2007). Two chronic motor training paradigms differentially influence acute instrumental learning in spinally transected rats. Behavioural Brain Research, 180, 95-101. [PMID:17434606] 5. Ferguson, A. R., Bolding, K.A., Huie, J. R., Hook, M. A., Santillano, D.R., Miranda, R.C. & Grau, J. W. (2008). Group I Metabotropic Glutamate Receptors Control Metaplasticity of Spinal Cord Learning through a PKC-Dependent Mechanism. Journal of Neuroscience, 28, 11939-11949. [PMID:19005059] [Free PMC article] 6. Ferguson, A.R., Christensen, R.N., Gensel, J.C., Miller, B.A., Sun, F., Beattie, E.C., Bresnahan, J.C., & Beattie, M.S. (2008). Cell death after spinal cord injury is exacerbated by rapid TNFα-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. Journal of Neuroscience, 28, 11391-11400. [PMID:18971481] [PMCID: PMC2598739] 7. Stück, E.D., Christensen, R.N., Huie, J.R., Tovar, C.A., Miller, B.A., Nout, Y.S., Bresnahan, J.C., Beattie, M.S., Ferguson, A.R. (2012). Tumor necrosis factor alpha mediate GABAA receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural plasticity. doi:10.1155/2012/261345 [PMID:22530155] [PMCID: PMC3317039] 8. Huie, J.R., Baumbauer, K.M., Lee, K.H., Bresnahan, J.C., Beattie, M.S., Ferguson, A.R.*, and Grau, J.W. (2012) Glial tumor necrosis factor alpha (TNFa) generates metaplastic inhibition of spinal learning. PloS One. http://dx.plos.org/10.1371/journal.pone.0039751 *corresponding senior author [PubMed - in process] [Free PMC Article] 9. Yuh, E.L., Cooper, S.A., Ferguson, A.R., Manley, G.T. (2012). Quantitative CT improves outcome prediction in acute traumatic brain injury. Journal of Neurotrauma, 29, 735-746. [PMID:21970562] [Free PMC Article] 10. Yuh, E.L., Mukherjee, P., Lingsma, H.F., Yue, J.K., Ferguson, A.R., Gordon, W.A., Valadka, A.B., Schnyer, D.M., Okonkwo, D.O., Maas, A.I.R., Manley, G.T. (2013). MRI and CT Improve 3-month outcome prediction in mild TBI. Annals of Neurology, 73, 224-35, doi: 10.1002/ana.23783. [PMID:23224915] [PubMed - in process]

D. Research Support

Ongoing Research Support

R01 NS069537 Ferguson (PI) 03/01/10-02/28/14 (in NCE) Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms This project explores cellular mechanisms that regulate a form of spinal cord plasticity that is thought to contribute to recovery after SCI. Role: Principal Investigator

R01 NS067092-01 Ferguson (PI) 05/01/10-04/30/15 Bioinformatics for Translational Spinal Cord Injury This project proposes to build a large database repository of basic spinal cord injury research data to enable multivariate datamining and knowledge discovery with the goal of identifying the best translational metrics for evaluating experimental therapeutics across species. Role: Principal Investigator

R01 NS038079-11 Bresnahan/Beattie (PIs) 09/01/11-08/31/16 Mechanisms of Secondary Damage After Spinal Cord Injury The aims of this project include extending current studies of AMPAR trafficking in neurons to glial cells, further testing the hypothesis that membrane AMPAR trafficking effects are recruited over time and space by the expanding wave of secondary injury, and using drugs that affect different points in the sequence of TNFa- mediated CP-AMPAR insertion to expand the preclinical evaluation of this target for clinical application. Role: Co-Investigator

R01 NS042291 Tuszynski (PI) 09/01/11-08/31/16 NIH/NINDS Plasticity and Regeneration in the Primate Spinal Cord This project supports studies of mechanisms of endogenous plasticity and recovery within the primate spinal cord following spinal cord injury. Role: Co-Investigator on UCSD Subaward to UCSF PI Bresnahan

IPA Tuszynski (PI) 01/01/09-09/30/13 VA RR and D Merit Review Award California Spinal Cord Injury Consortium This project supports a combinatorial treatment evaluation in the primate after spinal hemisection. Role: Statistician *salary support only, provided via IPA

W81XWH-10-1-0910 Beattie (PI) 09/01/10-08/31/13 DOD US Army Med. Res. Acq. Activity SCI with Brain Injury: Bedside to Bench Modeling for Developing Treatment and Rehabilitation Strategies This project supports a new collaboration between basic scientists at UCSF and clinicians at the UCSF, Palo Alto VA, the Santa Clara Valley Rehabilitation Center. Role: Co-Investigator

224308 Ferguson (PI) 07/01/12-06/30/14 Neilsen Foundation Visualizing Translational Spinal Cord Injury Research This project aims to improve clinical translation of basic SCI research findings through the development of a novel integrative toolkit for SCI data-mining and multivariate data visualization. Role: Principal Investigator

WFL-US-008/12 Ferguson (PI) 07/01/12-06/30/14 Wings for Life Foundation Datasharing and Bioinformatics for Previously Funded Projects This project aims to expand our ongoing database development for SCI research with data contributions from the European Union Role: Principal Investigator

Completed Research Support

F32 NS053059 Ferguson (PI) 03/03/07-02/28/10 Role of AMPAR Trafficking in Spinal Cord Injury This was a fellowship award to support my work on mechanisms of cell death in secondary injury after spinal cord trauma, focusing on excitotoxicity. Role: Principal Investigator

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Donna M. Ferriero, M.D. Professor of Neurology and Pediatrics eRA COMMONS USER NAME (credential, e.g., agency login) DFerriero EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Rutgers University, NCAS, NJ BA 1967-71 Zoology Rutgers University, New Brunswick, NJ MS 1971-73 Immunology Univ. Calif. San Francisco, CA MD 1975-79 Medicine Univ. Calif. San Francisco, CA postdoc 1985-87 Neurobiology A. Personal Statement As Principal Investigator of the Neonatal Brain Disorders Center, I have directed NIH-funded research for over 20 years. I have extensive mentoring experience as the PI of a K12 NSADA from NINDS since 1998. This grant requires expertise in training and mentoring that I have demonstrated through my existing funded proposals. I have mentored three KL2 scholars in addition to many K23 and K08 applicants. I have received multiple awards for mentoring, including the Chancellors Award for the Advancement of Women and the Maureen Anderson Award from the Society for Pediatric Research. Our Newborn Brain Research Institute offers rich resources for trainees who wish to pursue clinical and translational research and training at UCSF.

B. Positions and Honors 1998- present Professor and Chief Child Neurology (to 2010), UCSF, Neurology and Pediatrics 1998- present Member, Biomedical Sciences Graduate Program 2004-present Member, Institute for Regeneration Medicine 2005-11 Vice Dean, Academic Affairs, UCSF School of Medicine 2005 Institute of Medicine of the National Academy of Sciences 2007-present Co-Director, Newborn Brain Research Institute UCSF 2011-present Physician-in-Chief, UCSF Benioff Children’s Hospital 2011 Election to the Association of American Physicians 2013 Election to American Academy of Arts and Sciences

C. Selected Peer-reviewed Publications 1. 2001 Northington FJ, FERRIERO DM, Flock DL, Martin LJ. Delayed thalamic neurodegeneration after hypoxia-ischemia in neonatal rat diencephalon is programmed cell death. J. Neurosci 21:1931-1938. 2. 2002 Parent JM, Vexler ZS, Gong C, Derugin N, FERRIERO DM. Focal cerebral ischemia increases adult rat forebrain subventricular zone neuroblast proliferation and induces neostriatal neurogenesis. Ann Neurol 52(6):802-813 3. 2003 McQuillen PS, Sheldon RA, Shatz CJ, FERRIERO DM. Selective vulnerability of subplate neurons following early neonatal hypoxia ischemia. J Neurosci 23:3308-15 4. 2004 Chou W-H, Choi D-S, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, FERRIERO DM, Messing RO. Neutrophil protein kinase C delta as a mediator of stroke-reperfusion injury. J Clin Invest 114;49-56 5. 2008 Jiang X, Mu D, Faustino J, Chang S, Rincón CM, Sheldon RA, and FERRIERO DM. Activated Src family kinases have enhanced interaction with N-Methyl-D-Aspartate receptor after neonatal brain ischemia. Ann Neurol ;63(5):632-41 6. 2009 Miller SP and FERRIERO DM From selective vulnerability to connectivity: insights from newborn brain imaging. Trends in Neurosci 32(9):496-505 PMC2743801 7. 2010 Osredkar D, Sall J Bickler P and FERRIERO DM. Erythropoietin promotes hippocampal neurogenesis in in-vitro models of neonatal stroke. Neurobiol of Disease, Fe 1 epub. NIHMS 175788 8. 2010 Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero DM, McQuillen P. Subventricular Zone Type B Cells Do Not Contribute to Neurogenesis Following Neonatal Stroke. Devp Neurosci 32(2):101- 113 9. 2011 Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, FERRIERO DM. Hypoxia alone compared to ischemic-hypoxic forebrain injury is sufficient to induce cerebellar damage in the developing rat brain. Neurobiol of Disease an;41(1):138-46 10. 2011 Tam EWY, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, Fok EDY, Grunau R, Glidden D, Miller SP. Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids. Science Translational Medicine Oct 19;3(105):105ra105 11. 2012 Tymofiyeva O, Hess CP, Ziv E, Tian N. Bonifacio SL, McQuillen P. Ferriero DM, Barkovich AJ, and Xu D. Towards the Baby Connectome: Mapping the structural connectivity of the newborn brain. Plos One. Epub Feb 6, 2012 12. 2013 Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM. Erythropoietin increases neurogenesis and oligodendrogliosis of SVZ precursor cells after neonatal stroke Stroke .;44:753-758 13. 2013 van Velthoven C TJ, Sheldon,RA Kavelaars A, Derugin N, Vexler ZS, Willemen HDLM, Maas MM, Heijnen C, Ferriero DM. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke, Stroke. 2013 May;44(5):1426-32 14. 2013 Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D (2013) A DTI- Based Template-Free Cortical Connectome Study of Brain Maturation. PLoS ONE 8(5):e63310. doi:10.1371/journal.pone.0063310 15. 2013 Liu J, Sheldon RA, Segal M, Kelly MJS, Pelton JG, Ferriero DM, James TL, Litt L. 1H NMR brain metabolomics in a neonatal mouse hypoxia-ischemia model distinguishes mild hypothermia from normothermia recovery. Pediatric Research, May 24. doi: 10.1038/pr.2013.88 16. 2013 Pathipati P, Mueller S, Jiang X, Ferriero DM. Phenotype and secretory responses to oxidative stress in microglia. Dev Neurosci, 35(2-3):241-54. 17. 2013 Knox R, Zhao C, Miguel-Perez D, Wang S, Yuan J, Ferriero DM and Jiang X. Neuronal Fyn overexpression exacerbates brain injury following neonatal hypoxia- ischemia in mice. Neurobiology of Disease 51: 113-19 18. 2013 Zhao J, Qu Y, Wu J, Cao M, Ferriero DM, Zhang L, Mu D. PTEN inhibition prevents rat cortical neuron injury after hypoxia-ischemia. Neuroscience. May 15;238:242-51 19. 2013 Dzietko M, Derugin N, Wendland M, Vexler Z, Ferriero DM. Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke. Translational Stroke Res, 4 (2):189-200. 20. 2013 Semple, BD.; Blomgren, K; Gimlin, K; Ferriero, DM Noble-Haeusslein, LJ. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Progress in Neurobiology Apr 11. doi:pii: S0301-0082(13)00030-0

D. Research Support Active Type: PO1 (PI: Ferriero) 1/01/2014 – 12/31/201 Agency: NIH/ NINDS $ 824,286 (Year 1 directs) Title: Repair after Neonatal Brain Injury This grant proposes to study both structural and functional correlates of brain developmental maturation and network organization using advanced imaging techniques in our human populations and similar correlates in newborn rodents with a focus on defining basic mechanisms of repair. We will translate these findings to the development of appropriate hardware and software for imaging the fragile newborn to enhance our capabilities in understanding how and when reparative processes originate and are executed. Role: Principal Investigator

Type: Foundation Ferriero (PI) Period: 10/1/10-9/30/15 Agency: Fondation Leducq Transatlantic Network on Newborn Stroke: Inflammatory Modulation of Neurovascular Injury

Goal is to set up a network for training of junior investigators and a nidus for discovery of modulators of injury to bring to clinical trials. Role: Co- Principal Investigator

Type: P50 NS35902 Ferriero (PI) Period: 4/1/97-1/31/14 Agency: NINDS Title: Mechanisms of Ischemic Neonatal Brain Injury The goal of this project is investigate the role of ischemia in the generation of neonatal brain injury. Project 1 is evaluating MRI/S as predictors of outcome in humans; Project 2 is studying the role of fructose bis-phosphate; Project 3 is studying the role of growth factors; and Project 4 is studying the role of meningitis and inflammatory mediators- all after neonatal hypoxic-ischemic injury. The core is responsible for developing new models, housing the MR core and NIRS lab as well as centralizing techniques used in all projects. Administrative Supplement for Development of Preclinical Trials is to choose conditions for comprehensive testing of the hypothesis that hypothermia is neuroprotective. Role: Principal Investigator

Type: R01 NS033997 Ferriero (PI) Period: 4/1/96-1/31/17 Agency: NINDS Title: Oxidant Mechanisms in Neonatal Brain Injury The goal of this grant is to determine the mechanisms by which reactive oxygen species mediate cell death after hypoxic-ischemic insult in the developing nervous system. The PI is responsible for overall design and execution of the project. Role: Principal Investigator

Type: 2K12 NS001692- Ferriero (PI) Period: 7/15/98-6/30/14 Agency: NIH/NINDS Title: Neurological Sciences Academic Development Award Academic training grant for three candidates who will pursue a career in clinical or basic science related to genotype-phenotype correlations of childhood neurological diseases. Role: Principal Investigator

Type: R01 EB009756 Xu/Barkovich (Co-PI) Period: 9/1/09-6/30/14 Agency: NIBIB/Bioengineering Research Partnerships Title: Development of Advanced Techniques for MR of the Newborn Brain The goal of this project is to develop advanced MR tools for the evaluation of newborn brain at 3T. This bioengineering partnership consists of scientists and engineers from UCSF, Stanford, and MGH to develop not only the software tools but also hardware components for optimized acquisitions of the newborn brain. Role: Co-investigator

Type: R01 NS050159 Noble (PI) Period: 7/1/11-3/31/14 Agency: NIH/NINDS Trauma To Developing Brain -- Injury and Repair Mechanisms The major goal of this project is determine if increased activity of the antioxidant glutathione peroxidase (GPx) will reduce inflammation and cell injury thereby supporting structural and functional recovery. Role: Co-Investigator

Type: Child Neurology Foundation Ferriero (PI) Period: 1/1/06-12/31/13 Agency: CNF/CNS Multicenter Clinical Research Grant (no cost extension) Towards the establishment of a Multicenter, Multi-National Research Network for Neonatal Seizures This grant is to set up a consortium that will develop protocols for clinical trials in newborns with seizures. Role : Principal Investigator

Type: T32 HD044331 Ferriero (PI) Period: 5/1/07-4/30/14

Agency: NICHD Institutional Training for Pediatricians The goal of this application is to train future academic pediatricians for successful careers. Role : Principal Investigator

Type: R01 NS077767 Noble (PI) Period: 7/1/2012 - 6/30/17 Agency: NIH- Determinants of vulnerability and recovery after trauma to the developing brain Using genetic and pharmacologic approaches in a murine model of TBI, we will determine how unchecked, neutrophil elastase (NE)-directed proteolysis establishes an environment that is unfavorable to recovery and if early blockade of this activity supports cognitive recovery. These studies establish the basis for developing a NE-targeted therapeutic for the brain-injured child. Role: Co- Investigator

UCSF Foundation (PI: Ferriero) 12/1/2012 – 12/31/2015 as needed UCSF Pledge for Pediatrics $500,000 (total) A murine model of repetitive head injury Goals: to produce a murine model of repetitive head injury to evaluate the role of concussive changes and to test novel therapies to reverse brain damage Role: Principal Investigator

Program Director/Principal Investigator: Fitzsimmons

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Fitzsimmons, Amber Assistant Adjunct Professor eRA COMMONS USER NAME (credential, e.g., agency login) Fitzhike

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) UCSF/SFSU DPTSc 09/13 Physical Therapy Pacific University MS 06/96 Physical Therapy California Polytechnic State University BS 06/93 Biochemistry

A. Personal Statement My areas of research and academic interests are in health professional education using mixed method or qualitative research methodology. In my doctoral work, I investigated the extent and quality of interprofessional experiences of first year Doctor of Physical Therapy students in their first clinical clerkships. In my role as a faculty member, I am focused on imbedding interprofessional collaborative learning experiences in UCSF’s longitudinal curriculum for graduate-level learners in the schools of pharmacy, nursing, medicine, dentistry and physical therapy. I hold appointments in both the Department of Anatomy and Department of Physical Therapy and Rehabilitation Science. B. Positions and Honors Principals Positions Held 1996 1998 Saint Joseph Medical Center – Staff Physical Stockton, California Therapist 1998 1998 Group One / Ukiah Transitional Care Staff Physical Unit – Ukiah, California Therapist 1999 2000 Physical Therapy At The Health Club Director of Aquatic – Ukiah, California Rehabilitation

2000 2007 Saint Charles Medical Center, Bend, Staff Physical Oregon Therapist 2013 present University of California, San Assistant Adjunct Physical Therapy and Francisco Professor Rehabilitation Science 2013 present University of California, San Assistant Adjunct Anatomy Francisco Professor

Other Positions Held Concurrently 2013 present University of California, San Interprofessional Physical Therapy and Francisco Education Lead Rehabilitation Science

Honors Awards 2013 Graduate Student Award for Distinguished Achievement San Francisco State University 2012 Clinical Translational Research Fellowship (formerly called University of California, San Francisco PACCTR) 2011 Interprofessional Education Curriculum Ambassador University of California, San Francisco

Memberships 2009 present American Physical Therapy Association - Member, Education, Geriatric sections

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Fitzsimmons

2010 present American Association of Anatomists - Member 2009 present California Physical Therapy Association -Member

Service to Professional Organizations C. Selected Peer-Reviewed Publications 1. Fitzsimmons A, Cisneros B, and Samore J. 2013. Learner Developed Interprofessional Curriculum (doi:10.3109/13561820.2013.820692). 2. Rivera J, Yukawa M, Hyde S, Fitzsimmons A, Christman J, Gahbauer A, Scheid A, Wamsley M. Interprofessional Standardized Patient Exercise (ISPE): The Case of “Elsie Smith”. MedEdPORTAL; 2013. D. Research Support On-going Research Support

Completed Research Support TL1 RR024129 07/01/2011 - 07/31/2012 This project was supported by the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director, National Institutes of Health, through UCSF- CTSI Role:Trainee

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Karunesh Ganguly Assistant Professor, in residence eRA COMMONS USER NAME (credential, e.g., agency login) Staff Physician, Neurology & Rehabilitation Service KARUNESHG EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Stanford University BS 06/95 Chemistry University of California, San Diego MD 06/04 Medicine University of California, San Diego PhD 06/04 Neuroscience University of California, San Francisco 06/05 Internal Medicine University of California, San Francisco 06/08 Neurology University of California, Berkeley 6/12 Neural Engineering

A. Personal Statement I have multidisciplinary expertise in systems neuroscience, rehabilitation neurology and neural engineering. Our laboratory is interested in understanding the neural basis of biological sensorimotor learning and control, and how it can be used in brain-machine interfaces (BMI). BMIs offer the possiblity of allowing subjects with permanent motor disability to exert direct neural control over assistive devices. In addition, BMIs may eventually allow us to promote functional recovery after stroke and brain injury. We use computational as well as electrophysiological techniques. We are pursuing both animal-based basic research as well as clinical translational research. We currently use chronic electrophysiological recordings to understand the neurophysiological basis of motor recovery after stroke and brain injury. We are also testing how to incorporate artificial electronic systems into the nervous system. Moreover, we are testing the feasibility of controlling complex upper-limb exoskeleton systems using electrical potentials recorded from the cortical surface (i.e. electrocorticography or ECoG) in human subjects. Our research is funded by the Veterans Health Association, the Department of Defense and multiple private foundations. I have mentored both students and residents who are interested in rehabilitation and neuroscience research. Our laboratory also has six post-doctoral fellows with multidisciplinary training in bioengineering, neuroscience and clinical research.

B. Positions and Honors Positions and Employment 2008-2010 Instructor, Department of Neurology, University of California, San Francisco 2009- Staff Neurologist, San Francisco VA Medical Center 2010-2012 Assistant Adjunct Professor, Department of Neurology, University of California, San Francisco 2012- Assistant Professor, in residence Department of Neurology, University of California, San Francisco

Other Experience and Professional Memberships 2004- Member, American Academy of Neurology 2008- Society for Neuroscience 2008- American Heart Association/American Stroke Association

Honors 1994 Undergraduate Research Grant, Stanford University 1995 Phi Beta Kappa, Stanford University 1996-2004 Medical Scientist Training Program 2000-2002 National Science Foundation Graduate Fellowship 2004 Neurology Award for Outstanding Medical Student 2007 American Neurological Association Resident’s Program Scholarship 2009 Career Development Award, Veteran Health Association 2011 Burroughs-Wellcome Fund Career Award for Medical Scientists

C. Selected Peer-reviewed Publications Most relevant to the current application 1. Ganguly K and Poo MM. Activity-dependent neural plasticity from bench to bedside. Neuron (2013). 80(3): 729-41. 2. Ganguly K, Byl, NN and Abram, GM. Neurorehabilitation: Motor recovery after stroke as an example. Annals of Neurology (2013). 74(3). 373-381. 3. Canolty RT, Ganguly K, Carmena JM. Task-Dependent Changes in Cross-Level Coupling between Single Neurons and Oscillatory Activity in Multiscale Networks. PLoS Comput Biol. (2012). 4. Ganguly K, Abrams GM. Management of chronic myelopathy symptoms and activities of daily living. Semin Neurol. 2012 Apr; 32(2):161-8. 5. So K, Koralek AC, Ganguly K, Gastpar MC, Carmena JM. Assessing functional connectivity of neural ensembles using directed information. J Neural Eng. 2012 Apr; 9(2):026004. 6. Canolty RT, Cadieu CF, Koepsell K, Ganguly K, Knight RT, Carmena JM. Detecting event-related changes of multivariate phase coupling in dynamic brain networks. J Neurophysiol. 2012 Apr; 107(7):2020-31. 7. So K, Ganguly K, Jimenez J, Gastpar M and Carmena JM. Redundant information encoding in primary motor cortex during natural and prosthetic motor control. J. Comp. Neurosci. (2011). 8. Ganguly K and Carmena JM. Neural correlates of skill acquisition with a brain-machine interface. (2010) Journal of Motor Behavior. 42, 355-360. 9. Heliot R, Orsborn AL, Ganguly K and Carmena JM. System Architecture for Stiffness Control in Brain- Machine Interfaces. (2010). IEEE Transactions on Systems, Man, and Cybernetics, Part B. 40,1387-97. 10. Canolty R, Ganguly K, Kennerley S, Cadieu C, Koepsell K, Wallis L, Carmena J. Oscillatory phase coupling coordinates anatomically-dispersed functional cell assemblies. (2010) Proc. Natl Acad Sci U S A. 10.1073/pnas.1008306107. 11. Heliot R., Ganguly K, Jimenez J and Carmena JM. Learning in closed-loop brain-machine interfaces: modeling and experimental validation. (2010) IEEE Transactions on Systems, Man, and Cybernetics, Part A 40, 732-742 12. Ganguly K and Carmena JM. Emergence of a cortical map for neuroprosthetic function. (2009) PLoS Biology 7, 1-13. e1000153. 13. Ganguly K, Secundo L, Ranade R, Orsborn A, Chang EF, Dimitrov DF, Wallis JD, Barbaro NM, Knight RT and Carmena JM. Ensemble representation of ipsilateral arm movements in monkey and man. (2009) Journal of Neuroscience 29(41):12948-12956. 14. Ganguly K and Kleinfeld D. Goal-directed whisking increases phase-locking between movement and electrical activity in primary sensory cortex in rat. (2004) Proc Natl Acad Sci 101,12348-53. 15. Woodin MA, Ganguly K and Poo M-m. Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity. (2003) Neuron. 39, 807-820 16. Ganguly K, Schinder AF, Wong, ST and Poo M-m. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. (2001) Cell 105, 21-32. 17. Ganguly K, Kiss L and Poo M-m. Enhancement of presynaptic neuronal excitability by correlated presynaptic and postsynaptic spiking. (2000) Nature Neuroscience. 10, 18-26.

RESEARCH AWARDS AND GRANTS Active CDA-2B6674W, US Department of Veterans Affairs Ganguly (PI) 08/01/09-07/31/14 A Brain-Machine Interface Using the Ipsilateral Arm Representation Stroke is a major cause of disability as a result of unilateral damage to a brain hemisphere. This project aims to understand the neural basis of the ipsilateral neural representation and its possible use in a BMI. Role: PI

CAMS, Burroughs Wellcome Fund Ganguly(PI) 10/01/11-08/30/16 Control of a Complex Neuroprosthetic Device Using Electrocorticography ECoG signals can be recorded stably for extended periods. This proposal aims to test the use of ECoG based recordings to control complex prosthetic devices in non-human primates. Role: PI

CSDA, Doris Duke Charitable Foundation Ganguly(PI) 7/01/13-0630/16 ECoG Based Control of a Wearable Exoskeleton The goal of this grant is to test the development of ECoG BMIs in clinical patients undergoing epilepsy monitoring. Role: PI

W81XWH-13-2-0091, Dept. of Defense Swanson(PI) 09/27/13-09/30/16 “Mechanistic links between PARP, NAD, and brain inflammation after TBI” The goal of this project is to apply electrophysiological monitoring to rat model of TBI. Role: Co-PI

Pending Searle Scholar Ganguly(PI) 06/01/14-05/31/17 Closed-loop control of cortical plasticity This proposal aims to test the use of BMIs for rehabilitation in an animal model of stroke.

DP2, NINDS Ganguly(PI) 09/01/14-08/31/19 Neuroprosthetic Control of an Anthropomorphic Exoskeleton in Tetraplegics The proposal aims to conduct a clinical translation trial of BMIs using ECoG signals.

Completed 0875016N, American Heart Association Ganguly (PI) 07/01/08-06/30/1 A Brain-Machine Interface Using Local Field Potentials Role (PI)

BIOGRAPHICAL SKETCH

NAME POSITION TITLE HAMEL, KATHRYN A. Associate Professor eRA COMMONS USER NAME SFSUHAMEL EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) State University of New York at Buffalo B.S. 1996 Mechanical Engineering State University of New York at Buffalo M.S. 1998 Biomechanics/Exercise Science Pennsylvania State University, University Park, PA Ph.D. 2002 Biomechanics/ Kinesiology

A. Personal Statement As director of the MAREY lab at SFSU, my research priorities are currently focused on fall prevention in older adults with specific studies that address age-related changes in biomechanical and sensory integration. We have two major projects that we recently completed. The first was a NIH-funded study that looked at age-related changes in the visual control of locomotion. We simultaneously measured gaze behavior and biomechanical output in young and older adults during locomotion over challenging terrain such as obstacles, steps and stairs. The second was a pilot study looking at the developmental changes that occur in the visual control of locomotion in young children. In addition to our work on the visual control of locomotion, we began an Air Force funded project focused on deception detection at security checkpoints in the Fall of 2012 in collaboration with my colleague in Psychology, Dr. David Matsumoto. The aim of this study is to determine if deceptive behavior can be detected through the use of motion capture data during the walk up phase to a security checkpoint prior to the individual actually reaching the checkpoint itself. In addition to our research in the MAREY lab, I currently teach three graduate courses in the Kinesiology program – Advanced Biomechanics, Advanced Neuromotor Control and Physical Dimensions of Aging as well as the undergraduate course in Anatomical Kinesiology.

B. Positions and Honors. Professional Positions 1996-98 Research and Teaching Assistant, Biomechanics Laboratory, SUNY Buffalo 1997-98 Biomechanics Intern, Kristal Systems, Amherst, NY 1999-02 Graduate Student Researcher, Center for Locomotion Studies, Penn State University 2002-2005 Assistant Professor, University of California San Francisco, Department of Physical Therapy and Rehabilitation Science 2002-2005 Director of the Movement Analysis Laboratory, University of California San Francisco 2002-2005 Joint Bioengineering Graduate Group Faculty Member, University of California San Francisco/University of California Berkeley 2006-2008 Assistant Professor, San Francisco State University, Department of Kinesiology 2008-Present Associate Professor, San Francisco State University, Department of Kinesiology 2009-Present Director of the MAREY (Movement Analysis Research on Elderly and Young) Laboratory

Awards and Other Professional Activities 1997 SUNY Buffalo Carlton R. Meyers Graduate Student Award 1999-0 Penn State University Friedman Foundation Research Grant 1999-02 NIH/NIA Penn State University Interdisciplinary Research Training Fellowship in Gerontology 2000 Gait and Clinical Movement Analysis Society Young Investigator Award 2000 NIA “Taking the Next Step: Technical Assistance Workshop” 2000-01 International Society of Biomechanics Dissertation Grant

2001 Grant to participate in the “Aging in a Welfare State” course at Jönköping University, Sweden 2003 National Institute on Aging Summer Institute on Aging Research 2003 National Institute of Health, NICHD: Special Emphasis Review Panel member for RFA entitled “Biomechanical Modeling of Movement” 2005 Nominated for the Outstanding Faculty Mentorship Award at UCSF 2008 Western Society for Physical Education for College Women - Emerging Professional Award

C. Selected peer-reviewed publications (in chronological order).

Peer-reviewed publications (maiden name – Kathryn A Christina): 1. Christina, KA, White, SC & Gilchrist, LA. Effect of Localized Muscle Fatigue on Vertical Ground Reaction Forces and Ankle Joint Motion During Running. Human Mov Sci 20:3, pp 257-276, 2001. 2. White, SC, Gilchrist, LA & Christina, KA. Within Day Accommodation Effects on Vertical Reaction Forces for Treadmill Running. J Appl Biomech 18, pp 74-82, 2002. 3. Christina, KA and Cavanagh, PR. Ground Reaction Forces and Frictional Demands During Stair Descent: Effects of Age and Illuminance. Gait and Posture 15:2, pp 153-158, 2002. 4. Hamel, KA Investigations of Stair Negotiation in the Elderly. University Park, PA: The Pennsylvania State University; 2002, Ph.D. Thesis. 5. Hamel, KA and Cavanagh, PR: Observational Stair Performance in People Over 75 Years Old. Journal of the American Geriatrics Society 52:563-567, 2004. 6. Hamel, KA, Okita, N, Higginson, JS and Cavanagh, PR. Foot clearance during stair descent: effects of age and illumination. Gait and Posture 21:2, pp 135-140, 2005. 7. Wampler, MA, Hamolsky, D, Hamel, K, Melisko, M, Topp, KS: Case report: painful peripheral neuropathy following treatment with docetaxel for breast cancer. Clin J Oncol Nurs. 9:2, pp 189-193, 2005. 8. Hamel, KA, Okita, N, Bus, S and Cavanagh, PR: A Comparison of Foot/Ground Interaction During Stair Negotiation and Level Walking in Women. Ergonomics 48:8, pp 1047-1056, 2005. 9. Mehling, WE, Hamel, KA, Acree, M, Byl, NN, Hecht, FM: Randomized Controlled Trial of Breath Therapy for Patients with Chronic Low Back Pain. Alternative Therapies in Health and Medicine 11:4, pp 44-52, 2005. 10. Wampler, MA*, Topp, KS, Miaskowski, C, Byl, NN, Rugo, HS, Hamel, KA: Quantitative and clinical description of taxane-induced postural instability in women with breast cancer. Archives of Physical Medicine and Rehabilitation 88(8), pp 1002-1008, 2007. 11. Katzman, WB*, Sellmeyer, DE, Stewart, AL, Wanek, L, Hamel, KA: Changes in flexed posture, musculoskeletal impairments and physical performace following group exercise in community-dwelling older women. Archives of Physical Medicine and Rehabilitation 88(2), pp 192-199, 2007. 12. Wampler, MA*, Miaskowski, C, Hamel, KA, Byl, N, Rugo, H, Topp, KS: The Modified Total Neuropathy Score: a clinically feasible and valid measure of taxane-induced peripheral neuropathy in women with breast cancer. Journal of Supportive Oncology 4(8), pp W9-W16, 2006. 13. Pawlowsky, SB*, Hamel, KA, Katzman WB*: Stability of Kyphosis, Strength, and Physical Performance Gains One Year After a Group Exercise Program in Community-Dwelling Hyper-Kyphotic Older Women. Archives of Physical Medicine and Rehabilitation 90(2), pp 358-361, 2009. 14. Chew-Bullock, T., Anderson, D.I., Hamel, K.A., Gorelick, M., Wallace, S., Sidaway, B.: Kicking performance in relation to balance ability over the support leg Human Movement Science 31(6), pp 1615-1623, 2012. 15. Loverro, K.*, Mueske, N.*, Hamel, K.A.: Effects of locomotor task and marker placement on minimum foot clearance. Journal of Biomechanics 46(11), pp 1842-1850, 2013.

(* indicates graduate student working under the supervision of Dr. Hamel)

D. Research Support.

RESEARCH FUNDING UNDER REVIEW: Air Force Office of Scientific Research Feb. 2014-Jan. 2016 (Approved – pending award) Subcontract to San Francisco State University from Humintell, Inc. Co-PI (with PI Dr. David Matsumoto in Psychology): “Human deception detection from whole body motion analysis” Total costs: $215,000

Current Research Support Air Force Office of Scientific Research Sept. 2012 - Jan. 2014 Subcontract to San Francisco State University from Humintell, Inc.

Co-PI (with PI Dr. David Matsumoto in Psychology): “Human deception detection from whole body motion analysis” Total costs: $195,000

Completed Research Support Office of Research and Sponsored Programs Research Award 2011-2012 San Francisco State University Primary Investigator: “Age-related changes in the visual control of locomotion”

Office of Research and Sponsored Programs Research Award 2010 San Francisco State University Primary Investigator: “Age-related changes in the visual control of locomotion

Summer Stipend Award San Francisco State University Primary Investigator: “Age-related Changes in Visual Guidance Strategies” One month salary stipend (June 2007)

NIH Exploratory/Developmental Research Grant Award (R21): Sept. 1, 2007 – August 31, 2009 San Francisco State University Primary Investigator: “Age-related changes in visual guidance strategies”

Academic Senate Individual Investigator Grant: Dec. 2002 – Dec. 2004 University of California San Francisco “Visual Input Requirements for Safe Mobility in the Elderly” (Primary Investigator)

Toyota Motor Corporation: December 2003 – December 2004 PATH, UC Berkeley and UC San Francisco “Investigation of Elderly Drivers” (Co-primary Investigator)

Mt. Zion Health Fund/Osher Center: March 2003 – July 2004 University of California San Francisco Co-investigator (5% effort; PI – Wolf Mehling, MD)): “Randomized Controlled Trial on the Effects of Breath Therapy in Adult Patients with Chronic Low Back Pain”

REAC Shared Equipment Grant: June 2004-June 2005 Research Evaluation and Allocation Committee, School of Medicine, University of California, San Francisco Primary Investigator: Neurocom SMART Balancemaster

Friedman Foundation Research Grant Penn State University Frictional Demands During Overground Walking and Stair Negotiation (Principal Investigator)

International Society of Biomechanics Dissertation Grant Penn State University Biomechanics of Stair Descent Under Altered Visual Conditions (Principal Investigator)

Program Director/Principal Investigator (Last, First, Middle): Anton-Culver / subaward / UCSF Core Hiatt

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Robert A. Hiatt, M.D., Ph.D. Professor and Chair of Epidemiology and Biostatistics Director of Population Sciences and Deputy Director, eRA COMMONS USER NAME (credential, e.g., agency login) Helen Diller Family Comprehensive Cancer Center rhiatt EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Univ. of Michigan, Ann Arbor, MI B.A. 1964 Zoology Univ. of Michigan Med School, Ann Arbor, MI M.D. 1968 Medicine San Francisco General Hospital, San Francisco, CA Internship 1969 USPHS Hospital, San Francisco, CA Residency 1971 Internal Medicine Univ. of California, Berkeley, CA MPH, PhD 1972, 80 Epidemiology

A. PERSONAL STATEMENT

I am Professor and Chair of Epidemiology and Biostatistics at UCSF and also the Director of Population Sciences and Associate Director for the Helen Diller Family Comprehensive Cancer Center. I came to UCSF in 2003 after being the first deputy director of the National Cancer Institute's Division of Cancer Control and Population Sciences, where, among other things, I oversaw the extramural cancer epidemiology and health disparities programs. I am a past president of the American College of Epidemiology and the American Society of Preventive Oncology. Over the last three and a half decades as an investigator and Assistant Director of the Kaiser Permanente's Division of Research, as Director of the Northern California Cancer Center's Prevention Sciences Program, and as the Deputy Director of the National Cancer Institute's Division of Cancer Control and Population Sciences I have had multiple informal mentoring activities with scores of scientists. In recent year I have enjoyed increased opportunities to teach and mentor graduate students, post-doctoral fellows and young faculty. I am an active member of the UCSF Committee on Curriculum and Educational Policy. Finally, since assuming chair responsibilities in the Department of Epidemiology and Biostatistics I have focused attention on the development of a graduate PhD training program in Epidemiology & Translational Science that was approved and admitted its first students in the fall of 2010 and which is going along successfully in its early years. I have served as the Program Director for this graduate program and mentor all students in a bi-weekly PhD Epidemiology Seminar over the last three years. I believe strongly in the value of cross-disciplinary and inter-professional education in the health sciences and look forward toward lending my expertise to this newly proposed PhD program in Rehabilitation Sciences.

B. POSITIONS AND HONORS 1972 - 1973 Research Associate, Haile Sellassie I. University Addis Ababa, Ethiopia, George Williams Hooper Foundation, UCSF, San Francisco, CA 1974 Clinical Instructor in Medicine & Director, Employee Health Service, San Francisco General Hospital and University of California Medical School, San Francisco CA 1974, 76-81 Physician, Berkeley and Hayward Industrial Medical Groups, Berkeley and Hayward, CA 1974 - 1976 Chief, Parasitology Section, San Juan Laboratories, San Juan, Puerto Rico, Center for Disease Control, US Public Health Service 1977 - 1998 Epidemiologist, Senior Epidemiologist (77-90), Assistant Director (91-98), Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 1980 - 1987 Lecturer, Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco, CA

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Anton-Culver / subaward / UCSF Core Hiatt 1981 - 1997 Lecturer, Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 1981 - 1986 Physician, Internal Medicine, Berkeley Family Practice Medical Group, Berkeley, CA 1988 - 1998 Associate Director for Detection, Prevention & Education (81-86), Director of Prevention Sciences (93-98), Northern California Cancer Center, CA 1998 - 2003 Deputy Director, Division of Cancer Control & Population Sciences, National Cancer Institute, NIH, Bethesda, MD 2003 - 2007 Senior Scientist, The Permanente Federation, Kaiser Permanente Medical Care Program, Oakland, CA 2003 - Director of Population Sciences and Deputy Director, UCSF Comprehensive Cancer Center and Professor of Epidemiology & Biostatistics, UCSF School of Medicine 2006 - Adjunct Investigator, Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 2006 - Chair, Department of Epidemiology & Biostatistics, UCSF School of Medicine 2007 - Senior Advisor, Community Health Initiative, Kaiser Foundation Health Plan 2008 - Adjunct Professor, Division of Epidemiology, School of Public Health, University of California, Berkeley

Awards and Other Professional Activities 1967 – 68, Victor Vaughn Medical Historical Society, University of Michigan Medical School; 1968, Department of Health, Education and Welfare, Children’s Bureau Fellowship, Belgrade, Yugoslavia; 2001, National Institutes of Health Merit Award, Quality of Cancer Care Committee; 2002, National Institutes of Health Merit Award, Cancer Progress Report; 2002, National Institutes of Health Director’s Award, Cancer Progress Report; 2003-present, Advisory Committee on Research, National Cancer Institute of Canada, Toronto, Ontario, Canada; Member: American Public Health Association, Society for Epidemiologic Research, American Society of Preventive Oncology (President 2003-05), American Epidemiological Society, American College of Epidemiology (President 1998-99), American College of Preventive Medicine, Cancer Prevention Committee, American Association of Cancer Research, Extramural Research Council, American Cancer Society.

Professional Qualifications Medical Licensure: California C-32334, Michigan 29031; 1974 American Board of Preventive Medicine, Fellow; 1971 American Board of Internal Medicine, Eligible; 1986 American College of Epidemiology, Fellow

C. SELECTED PUBLICATIONS (Since 2010 - total of 173) 1. Kranick JA, Schaefer C, Rowell S, Desai M, Petrek JA, Hiatt RA, Senie RT. Is pregnancy after breast cancer safe? The Breast Journal 2010; 16(4)404-411. PMID: 20522097. 2. Windham GC, Pinney SM, Sjodin A, Lum R, Jones RS, Needham LL, Biro F, Hiatt RA, Kushi LH. Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in U.S. girls. Environ Research 2010; 110:251-257. PMID 20129604. 3. Hade EM, Murray DM, Pennell ML, Rhoda D, Paskett ED, Champion VL, Crabtree B, Dietrich A, Dignan MB, Framer M, Fenton JJ, Flocke S, Hiatt RA, Hudson S, Mitchell M, Monahan P, Strickland PO, Shariff- Marco S, Stange K, Stewart SL. Intraclass correlation estimates for cancer screening outcomes: estimates and applications in the design of group randomized cancer screening studies. J Natl Cancer Inst Monogr. 2010; 40:97-103. PMID: 203386058. 4. Widome R, Samet JM, Hiatt RA, Luke DA, Orleans T, Ponkshe P, Hyland A. Science, prudence and politics: The case of smoke-free indoor spaces. Ann Epidemiol 2010; 20:428-35. PMID 20470969. 5. Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, Kushi LH, Erdman C, Hiatt RA, Rybak ME, Calafat AM and the Breast Cancer and Environment Research Centers. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates and phenols and pubertal stages in girls. Environ Health Perspectives 2010; 118(7):1039-1046. PMID 20308033. 6. Singh GK, Siahpush M, Hiatt RA, Timsina LR. Dramatic increase in obesity and overweight prevalence and body mass index among ethnic-immigrant and social class groups in the United States, 1976-2008. J Comm Health (published on line 12 June 2010 - DOI 10.1007) PMID: 20549318 7. Hiatt RA. The epicenter of translational science. Am J Epidemiol 2010;172(5):525-527. PMID: 20688901 PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Anton-Culver / subaward / UCSF Core Hiatt 8. Braithwaite D, Satariano WA, Sternfeld, B, Hiatt RA, Ganz PA, Kerlikowske K, Moore DH, Slattery ML, Tammemagi M, Castillo A, Melisko M, Esserman L, Weltzien E, Caan BJ. Long-term prognostic role of functional limitations among women with breast cancer. J Natl Cancer Inst; 2010; 102:1468-77. PMID: 20861456 9. Chlebowski RT, Johnson KC, Lane D, Pettinger M, Kooperberg CL, Wactawski-Wende J, Rohan T, O’Sullivan MJ, Yasmeen S, Hiatt RA, Shikany JM, Vitolins M, Khadekar J, Hubbell A. 25-Hydroxyvitamin D concentration, vitamin D intake and joint symptoms in postmenopausal women. Maturitas 2011;68:73-78. PMID 2109333181 10. Deardorff J, Ekwaru MA, Kushi L, Ellis B, Greenspan LC, Mirabedi A, Landaverde EG, Hiatt RA. Father absence, BMI and pubertal timing in girls: differential effects by family income and ethnicity. J Adolesc Health 2011; 48:441-7. PMID 21501801 11. Ponce NA, Tsui J, Knight SJ, Afable-Munsuz A, Ladabaum U, Hiatt RA, Haas JS. Disparities in cancer screening in individuals with a family history of breast or colorectal cancers. Cancer 2011 (in press) 12. Hiatt RA. Epidemiologic Basis of the Role of Environmental Endocrine Disruptors and Breast Cancer. In Russo J. Breast Cancer and the Environment. 2011 13. Willet WC, Colditz GA, Hiatt RA. Combating environmental causes of cancer. Response to Christiani. N Engl J Med 2011;364:2266. 14. Deppen SA, Aldrich MC, Hartge P, Berg CD, Colditz GA, Petitti DB, Hiatt RA. Cancer screening: the journey from epidemiology to policy, Ann Epidemiol 2012; 22:439-45. PMID:22626002 15. Braithwaite D, Izano M, Moore DH, Kwan ML, Tammemagi MC, Hiatt RA, Kerlikowshe K, Kronke CH, Sweeney C, Habel L, Castillo A, Weltzien E,Caan B. Smoking and survival after breast cancer diagnosis: a prospective observational study and systematic review.Breast Cancer Res Treat 2012;136:521-533. PMID 23053660 16. Khoury M, Lam T, Ioannidis J, Hartge P, Spitz M, Buring J, Chanock S, Croyle R, Goddard K, Ginsburg G, Herceg Z, Hiatt R, Hoover R, Hunter D, Kramer B, Lauer M, Meyerhardt J, Olopade O, Palmer J, Sellers T, Seminara D, Ransohoff D, Rebbeck T, Tourassi G, Zauber A, Winn D, Schully S. Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev 2013;22:508-16. PMID:23462917 17. Hiatt RA, Sulsky S, Aldrich MC, Kreiger N, Rothenberg R. Promoting innovation and creativity in epidemiology for the 21st century. Ann Epidemiol 2013; 23:452-454. PMID 23790350 18. Elson S, Hiatt RA, Anton-Culver H, Howell L, Naeim A, Parker B, van 't Veer L, Hogarth M, Hajopoulos K, Esserman L, the Athena Breast Health Network. The Athena Breast Health Network: Developing a rapid learning system in breast cancer prevention, screening, treatment and care. Breast Cancer Res Treat 2013 Jul 26 [Epub ahead of print]. PMID 2388767 19. Biro FM, Greenspan LC, Galvez MP, Pinney SM, Teitelbaum S, Windham GC, Deardorff J, Herrick R, Succop PA, Hiatt RA, Kushi LH, Wolff MS. Onset of breast development in a longitudinal cohort. Pediatrics 2013, Nov 4 (Epub ahead of print, PMID 24190685) 20. Barrett MA, Humblet O, Hiatt RA, Adler N. Big Data and disease prevention: from quantified self to quantified communities. Big Data. Sep 2013, 1(3): 168-175. doi:10.1089/big.2013.0027

D. Research Support Ongoing Research Support P30 CA82103-14 (McCormick) 09/19/12 - 05/13/17 NIH/NCI Cancer Center Support Grant Major goals: The Cancer Center Support Grant provides support for administration and infrastructure for the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). Role: Director of Population Sciences and Associate Director of the HDFCCC

01 ES019457 (Hiatt) 09/01/10 – 04/30/15 NCI/NIEHS Breast Cancer and the Environment Research Program Coordinating Center

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Anton-Culver / subaward / UCSF Core Hiatt Major goals: The BCERP CC works with three integrated cohorts of girls in centers across the country to study potential environmental causes of breast cancer by focusing on factors in puberty and adolescence. Role: Principal Investigator

RO1 (Shim) 07/01/10 - 06/30/14 NIH/NHGRI Conceptions of Race and Ethnicity used in Gene-Environment Interaction Studies Major goals: To anticipate and analyze how conceptions of race and ethnicity used in gene-environment interaction (GEI) research influence societal understandings of race, ethnicity, and individual and group identity; and to identify how policies and practices regarding conceptualization, measurement, and interpretation of race and ethnicity in genomic research might be elaborated in ways that render them more meaningful or robust. Role: Co-Investigator

U01 ES019435-01 (Kushi) 09/03/10-04/30/15 NCI/NIEHS The CYGNET Study: Environmental and Genetic Determinants of Maturation of Girls Major goals: To pursue hypotheses related to early development, puberty and adolescence with a focus on the influence of social determinants including socioeconomic status, race and ethnicity, the built environment, and other related issues like assessments of wealth, residential segregation and various stress pathways that might explain various social factors affecting early development and maturation in girls. Role: Co-investigator

P60 MD006902 (Bibbins-Domingo) 08/27/12 – 02/28/17 NMHHD The Center for Health and Risk in Minority Youth and Adults (CHARM) - To create the Center for Health And Risk in Minority youth and adults (CHARM), a new comprehensive center of excellence that will focus on chronic conditions and chronic disease risk in Latinos, African Americans and Asians across the arc from adolescence to young adulthood (age 8 to 35 years) as targeted prevention at this age group has the potential to greatly impact minority health and health disparities. Role: Co-Investigator

P30 A1027763 (Van Loon, K.) 07/01/11 – 02/28/14 Center for AIDS Research (CFAR) Building a Population-Based Cancer Registry in Dar es Salaam, Tanzania: A Pilot Project to Evaluate Completeness + Validity of Pathologic Data Major goals: As a pilot to developing a Cancer Registry for Tanzania this project assesses the completeness and accuracy of diagnoses of HIV related malignancies in Dar es Salaam, Tanzania over a 3 month period. Role: Mentor and Co-investigator

The Robert Wood Johnson Foundation (Adler) 09/03/10 – 4/30/15 The Robert Wood Johnson Health and Society Scholars Program: Implementation Phase Major goals: To implement an interdisciplinary, post-doctoral training program focused on the contextual, behavioral and biological determinants of health in order to improve the health of populations. Role: Primary Faculty and Mentor

COMPLETED Research Support (Since 12/2010)

5995SC Esserman (UC Systemwide PI) 01/01/10-12/31/12 UC Office of the President, Multi-campus Research Programs and Initiatives (MRPI) award Athena Breast Health Network

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Anton-Culver / subaward / UCSF Core Hiatt Major goals: The aim of the MRPI award is to support innovative collaborations that assemble multi- disciplinary, statewide teams of UC experts to focus their efforts around specific research areas important to California. MRPI funding for Athena supports the development of an infrastructure, shared across all UC medical centers, to integrate clinical data with research and learning and thus accelerate advancements in breast cancer prevention, screening, and treatment. Role: Co-Investigator

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Wendy B. Katzman, PT, DPTSc Associate Professor eRA COMMONS USER NAME WKATZMAN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) FIELD OF INSTITUTION AND LOCATION DEGREE mm/yy (if applicable) STUDY University of Texas Medical Branch, Galveston, TX BS 8/73 Physical Therapy International Society of Clinical Densitometry Certificate 8/03 Clinical Densitometry University of California San Francisco/San Francisco State University, DPTSc 6/06 Physical San Francisco, CA Therapy and Rehab Sci University of California, San Francisco, CA Certificate 5/09 Clinical Research

A. Personal Statement As a physical therapist and board certified Orthopedic Clinical Specialist, my research interests focus on age- related hyperkyphosis, an excessive curvature in the thoracic spine, and its effects on physical function in older adults. Hyperkyphosis affects approximately 14-40% of older adults and increases risk of morbidity and mortality. I am PI of an NIH RO1 grant from the National Institute of Aging, conducting a randomized controlled trial of the effects of a high-intensity spinal muscle strengthening exercise intervention on kyphosis, physical function and quality of life in community-dwelling older adults with hyperkyphosis. I am also project leader for a UCDavis P50 program project grant from the NIH Office of Research in Women’s Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases investigating sex differences in musculoskeletal conditions across the lifespan. I currently teach graduate students throughout the UCSF campus about management of osteoporosis and pelvic floor muscle dysfunction, and I provide an independent study course for physical therapy graduate students who are interested in participating in clinical research.

B. Positions and Honors

Positions and Employment: 1973-1974 Physical Therapist, Texas Institute for Rehabilitation and Research, Houston, TX 1974-1979 Physical Therapist, Pacific Medical Center, San Francisco, CA 1979-1982 Physical Therapist, Contract Physical Therapy, Berkeley, Oakland, CA 1982-1983 Chief Physical Therapist, Easter Seal Rehabilitation Center, Oakland, CA 1983-1985 Physical Therapist, Colby-Webster Physical Therapy, Berkeley, CA 1988-1993 Senior Physical Therapist, Patsi Sinnott and Associates, San Francisco, CA 1988-1994 Private Practice, Berkeley, CA 1988-1995 Director of Physical Therapy, Physiotherapy Associates, Berkeley, CA 2006 Project Director, UCSF Women’s Health Research Center, San Francisco, CA 2001-2004 Clinical Instructor, UCSF Department of PT and Rehab Science, SF, CA 2004-2010 Assistant Professor, UCSF Department of PT and Rehab Science, SF, CA 2010-current Associate Professor, UCSF Department of PT and Rehab Science, SF, CA Other Experience and Professional Memberships: 1987-current Clinical Faculty, University of California San Francisco/San Francisco State University Joint Graduate Program in Physical Therapy 1973-current American Physical Therapy Association (APTA), Geriatric, Research and Women’s Health Sections 1996-2000 National Osteoporosis Foundation 2010-current Gerontological Society of America 2010-current American Society for Bone and Mineral Research Honors and Awards: 2004 California Physical Therapy Fund Award 2005 Mt. Zion Health Fund Clinical Award 2005 APTA Geriatric Section - Adopt-A-Doc Award 2006 SFSU Graduate Student Distinguished Achievement Award 2007 CAPTA Best Faculty Manuscript Award 2010 ASBMR Travel Award 2008-2012 UCSF-Kaiser Building Interdisciplinary Research Careers in Women’s Health Scholar 2009-2012 UCSF CTSI KL2 Scholar’s Program

C. Peer-Reviewed Publications 1. Katzman WB, Sellmeyer DE, Stewart AL, Wanek L, Hamel KA. Changes in flexed posture, musculoskeletal impairments and physical performance after group exercise in community-dwelling older women. Arch Phys Med Rehabil. 2007; 88:189-199. PMID: 17270517 2. Pawlowsky S, Hamel K, Katzman WB. Stability of kyphosis, strength, and physical performance gains one year after a group exercise program in community-dwelling hyper-kyphotic older women. Arch Phys Med Rehabil 2009: 90:358-361. PMC2907351, PMID:19236993 3. Katzman, WB, Wanek, L, Shepherd, J, Sellmeyer, D. Age-related hyperkyphosis: Its causes, consequences and management. J Orthop Sports Phys Ther. 2010: 40 (5); 351-360. PMCID: PMC2907357 4. Katzman, WB, Vittinghoff, E, Kado, DM. Age-related hyperkyphosis, independent of spinal osteoporosis, is associated with impaired mobility in older community-dwelling women. Osteoporos Int. 2011 Jan;22(1):85-90. Epub 2010 May 18. PMC2958231, PMID: 20480146 5. Katzman WB, Vittinghoff, E, Ensrud, K, Black, D, Kado, DM. Increasing kyphosis predicts worsening mobility among older community-dwelling women: A prospective cohort study. J Am Geriatr Soc. 2011 Jan;59(1):96-100. PMID: 21198460 6. Katzman, W, Cawthon, P, Hicks, G, Vittinghoff, E, Shepherd, J, et al., Association of spinal muscle composition and prevalence of hyperkyphosis in healthy community-dwelling older men and women. J Gerontol A Biol Med Sci. 2011 Oct;26(10):2378-88. PMCID:PMC3297013 7. Knight, S, Luft, J, Nakagawa, S, Katzman, WB. Comparisons of pelvic floor muscle performance, anxiety, quality of life and life stress in women with dry overactive bladder. BJU Int. 2011 Oct 13. PMID: 21995304 8. Pastore, L & Katzman, WB. Recognizing myofascial pelvic pain in the woman with chronic pelvic pain. J Obstet Gynecol Neonatal Nurs. 2012 Aug 3. PMID: 22862153 9. Kado,DM, Huang, MH, Karlamangla, AS, Cawthon, P, Katzman, W, et al. Factors associated with kyphosis progression in older women: 15 years experience in the Study of Osteoporotic Fractures. J Bone Miner Res. 2013 Jan;28(1):179-87. PMID: 22865329, PMCID:PMC3693545 10. Katzman, WB, Huang, M, Lane, NE, Ensrud, K, Kado, DM. Hyperkyphosis and Decline in Physical Function in Older Community Dwelling Women: The Study of Osteoporotic Fractures (SOF). J of Gerontol Med Sci. 2013 Aug;68(8):976-83. PMID: 23633167 11. Bansal S, Katzman WB, Giangregorio LM. Exercise for improving age-related hyperkyphotic posture: a systematic review. Arch Phys Med Rehabil. 2014 Jan;95(1):129-40. PMID: 23850611 12. Katzman WB, Miller-Martinez D, Marshall LM, Lane NE, Kado DM. Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the osteoporotic fractures in men (MrOS) research group. BMC Musculoskelet Disord. 2014 Jan 16;15(1):19. PMID: 24428860

D. Research Support

Ongoing Research Support: NIA R01 AG041921 Katzman, WB (PI) 09/30/2012 – 08/30/2017 Study of Hyperkyphosis, Exercise and Function – SHEAF $2,435,662 This is a randomized controlled trial of a targeted exercise intervention to determine the effects on kyphosis and physical function in 100 community-dwelling older men and women with hyperkyphosis. Role: PI

NIH P50 AR063043 Lane, NE (PI) 09/01/2012 - 08/30/2017 Specialized Center of Research; subcontract with UCDavis $625,000 Sex Differences in Musculoskeletal Conditions across the Lifespan The goal of this project is to investigate sex differences in musculoskeletal issues acorss the lifespan. As project director of the kyphosis project, we will conduct a clinical trial of a targeted exercise intervention among 100 community-dwelling older men and women to determine effects on kyphosis, and to determine sex differences in response to the intervention. Role: Project leader

NIH/NIAMS RO1 Kado, DM (PI) 09/01/12-03/31/14 Biological and Structural Predictors of Kyphosis Progression in Older Men $94,134 The scope of the proposed projects are 1) to investigate the association of spinal muscle variables with the degree of kyphosis in older men in cross-sectional analysis in the Osteoporotic Study of Fractures in Men Study (MrOS cohort), and 2) to investigate allele variants for excessive degrees of kyphosis from the MrOS genome-wide association study. These analyses are part of Dr. Kado’s RO1 to investigate predictors of hyperkyphosis in the MrOS cohort. Role: Co-investigator

Completed During the Last three Years: NIH/NIAMS K24 PA-04-107 Lane, NE (PI) 07/01/12-12/31/12 NIH Midcareer investigator award in patient-oriented research $20,000 The goal of this subcontract is to conduct a genome-wide association study of kyphosis defined by the Cobb angle of kyphosis in a meta-analysis of data in the Health, Aging and Body Composition study (Health ABC), the Study of Osteoporotic Fractures (SOF), and the Osteoporotic Study of Fractures in Men Study (MrOS). Role: Investigator

NIAID U01 AI34989-19 Greenblatt, R (PI) 07/01/12-12/31/12 Women’s Interagency HIV Study (WIHS) IV $14,112 This funding supported the development of new musculoskeletal measurements of kyphosis and spinal muscle strength variables to be included in the Musculoskeletal substudy in WIHS-IV and future WIHS-V cohort of post-menopausal HIV-infected women. Role: Investigator K12 - 5K12 HD052163 Katzman (PI) 07/01/2008 – 06/30/2012 NIH UCSF-Kaiser Building Interdisciplinary Research Careers in Women’s Health The goal of this mentored career development award was to complete the UCSF Advanced Training in Clinical Research (ATCR) program, and develop relationships with established researchers to collaborate on numerous projects to determine important associations of hyperkyphosis and physical function. Role: PI

UCSF Resource Allocation Program Katzman (PI) 09/01/2009 – 12/31/2010 Collaboration with the UCSF Women’s Health Clinical Research Center Predictors of Kyphosis and Impaired Physical Function in Elderly Women in Health ABC

The goal for this research was to measure kyphosis angle from already existing computed tomography scans and answer important research questions about spinal muscle density among older adults with hyperkyphosis using data from an NIH-sponsored, multicenter, prospective cohort study – Health, Aging and Body Composition (Health ABC). Role: PI

Pfizer Pharmaceuticals Katzman (PI) 09/01/2007 – 03/31/2009 Investigator Initiated Grant Case control study of sEMG Performance of the Pelvic Floor Muscles in Women with Dry Overactive Bladder Compared to Asymptomatic Women As PI on this study, I wrote the proposal, obtained CHR approval, developed testing protocols, collected data, and participated in analyzing data and writing the published manuscript. Role: PI

Kazakia GJ Page 3

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Kazakia, Galateia J Assistant Professor In Residence eRA COMMONS USER NAME kazakia EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Cornell University B.S. May 1995 Mechanical Engineering

University of California, Berkeley M.S. May 2001 Bio/Mechanical Eng.

University of California, Berkeley Ph.D. Dec 2004 Bio/Mechanical Eng.

University of California, San Francisco Postdoctoral 2004-2008 Radiological Imaging

A. Personal Statement I have extensive experience using advanced in vivo imaging techniques including high resolution peripheral quantitative computed tomography (HR-pQCT) and magnetic resonance imaging (MRI) to investigate bone quality in health and disease. My expertise in bone quality assessment is aligned with the responsibilities I would undertake in mentoring students in this program. I began developing this expertise during my graduate studies at UC Berkeley. My PhD focused on bone mechanics, including mechanical testing and finite element analysis of human tissue and engineered bone substitutes. During my postdoctoral fellowship, supported by a NIH F32 award, I expanded my interest in bone quality assessment to include advanced imaging techniques. These two areas of expertise – bone mechanics and advanced imaging technology – inform and motivate my research directions in my current position as Assistant Professor. At the start of my faculty position, I was awarded a NIH/NIAMS Career Development Award (K01) to develop techniques and metrics for in vivo characterization of cortical pore structure. This work is ongoing and the novel bone quality assessment tools being developed will be applied to the data obtained in this proposed research. Building on this area of expertise, I was recently awarded a NIH R03 to perform ex vivo analysis of cortical bone pore contents and cellular environment in cadaver specimens. In my time as Assistant Professor, I have directed and participated in numerous human subject studies of both longitudinal and cross-sectional design focused on in vivo bone density, structure, and strength assessment. Among the human subject studies I have performed most recently are HR-pQCT and MR imaging studies investigating bone quality in the context of aging in a post-menopausal cohort, disuse in young athletes, gastric bypass surgery in a morbidly obese cohort, fracture in type II diabetics, and exercise in an elderly HIV+ population. These studies have provided exciting preliminary data and evidence of striking increases in cortical porosity. Importantly, we have found evidence of unique pathways of pore expansion among the cohorts we have studied. We plan to investigate this further to pinpoint systems associated with pore expansion in the context of aging, and to begin to isolate mechanisms and potential treatment and prevention strategies. Through these experiences I feel I have the ability to make a significant contribution to the proposed PhD program in Physical Therapy and Rehabilitation Science, and I would be happy to mentor students in this program that have interests that align with mine.

Kazakia GJ Page 4 B. Positions and Honors

Positions and Employment 1995-1998 Design Engineer, Biomechanics and Biomaterials, Hospital for Special Surgery, NY 1998-1999 Research Engineer, Biomechanics and Biomaterials, Hospital for Special Surgery, NY 1999-2004 Graduate Student Researcher, Mechanical Engineering, UC Berkeley, CA 2002 Graduate Student Instructor, Mechanical Engineering, UC Berkeley, CA 2004-2008 Postdoctoral Scholar, Radiology, UC San Francisco, CA 2009-2009 Associate Specialist, Radiology, UC San Francisco, CA 2009-present Assistant Professor in Residence, Radiology, UC San Francisco, CA

Other Experience and Professional Society Memberships 2005-present American Society of Bone and Mineral Research 2007-present American Association for the Advancement of Science 2013-present Orthopaedic Research Society 2008 Grant Reviewer for the American Institute of Biological Sciences 2008-present Associate Editor for Medical Physics 2012-present Scientific Advisory Board member for the International Conference on the Chemistry and Biology of Mineralized Tissues 2012-present Selection Committee member for the UC Office of Undergraduate Research Summer Research Fellowship Program 2013-present Abstract Reviewer for the Orthopaedic Research Society

Honors 1999-2002 Graduate Research Fellowship, NSF 2005-2007 National Research Service Award (F32 AR053446), NIH/NIAMS 2006 Young Investigator Award, 36th International Sun Valley Workshop on Skeletal Biology 2006 Excellence in Research Award, Musculoskeletal Quantitative Imaging Research Group, UCSF 2009 Mentored Career Development Award (K01 AR056734), NIH/NIAMS

Patents 1999 Rotationally Ratcheting Bone Screw, US 5997538 2000 Lateral Pelvic Positioner for Total Hip Arthroplasty, US 6311349

C. Selected Peer-reviewed Publications

Most relevant to the current application 1. Kazakia G.J., Hyun B., Burghardt A.J., Krug R., Newitt D.C., de Papp A., Link T.M., Majumdar S.: In vivo Determination of Bone Structure in Post-menopausal Women: A Comparison of HR-pQCT and High-field MR Imaging. Journal of Bone and Mineral Research 2008; 23(4):463-474. PMID: 18052756 2. Kazakia G.J., Burghardt A.J., Cheung S., Majumdar S.: Assessment of Bone Mineralization by Conventional X-ray Micro-Computed Tomography: Comparison with Synchrotron Radiation Micro- Computed Tomography and Ash Measurements. Medical Physics 2008; 35(7):3170-3179. PMCID: PMC2673562 3. Burghardt A.J., Kazakia G.J., Link T.M., Majumdar S.: Automated Simulation of Areal Bone Mineral Density Assessment from High Resolution Peripheral Quantitative Computed Tomography. Osteoporosis Imaging 2009; 20(12):2017-24. PMCID: PMC2777210 4. +Sekhon K., +Kazakia G.J., Burghardt A.J., Hermannsson B.J., Majumdar S.: Accuracy of Volumetric Bone Mineral Density Measurement in High Resolution Peripheral Quantitative Computed Tomography. Bone 2009; 45(3):473-9. PMID: 19501201 +Authors contributed equally to manuscript preparation. K. Sekhon worked as an undergraduate apprentice under the direct supervision and mentorship of G.J. Kazakia. *GJK corresponding author.

Kazakia GJ Page 5 5. Goldenstein J., Kazakia G.J., Majumdar S.: In Vivo Evaluation of the Presence of Bone Marrow in Cortical Porosity in Postmenopausal Osteopenic Women. Annals of Biomedical Engineering 2010; 38(2):235-46. PMCID: PMC2815796 6. Burghardt A.J., Kazakia G.J., Ramachandran S., Link T.M., Majumdar S.: Age and Gender Related Differences in the Geometric Properties and Biomechanical Significance of Intra-Cortical Porosity in the Distal Radius and Tibia. Journal of Bone and Mineral Research 2010; 25(5):983-93. PMCID: PMC3153365 7. Burghardt A.J., Kazakia G.J., Sode M., de Papp A.E., Link T.M., Majumdar S.M.: A Longitudinal HR-pQCT Study of Alendronate Treatment in Post-menopausal Women with Low bone Density: Relations between Density, Cortical and Trabecular Micro-architecture, Biomechanics, and Bone Turnover. Journal of Bone and Mineral Research; Epub 18 JUN 2010 DOI 10.1002/jbmr.157. PMCID: PMC3179276 8. Kazakia G.J., Burghardt A.J., Link T.M., Majumdar S.: Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. Journal of Biomechanics 2011; 44(2):257-66. PMCID: PMC3019283 9. Kazakia G.J., Speer D., Shanbhag S., Majumdar S., Conklin B.R., Nissenson R.A., Hsiao E.C.: Mineral Composition is Altered by Osteoblast Expression of an Engineering G(s)-coupled Receptor. Calcified Tissue International 2011; 89(1):10-20. PMCID: PMC3110278 10. +Tjong W., +Kazakia G.J., Burghardt A.J., Majumdar S.: The Effect of Voxel Size on High- Resolution Peripheral Computed Tomography Measurements of Trabecular and Cortical Bone Microstructure. Medical Physics 2012; 39:1893-1903. PMCID: PMC3316694 +W. Tjong worked as a Research Assistant under the direct supervision of G.J. Kazakia. *GJK corresponding author. 11. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. Age- and gender- related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2012 Nov 7. PMCID: PMC3564644 12. Kazakia G.J., Kuo D., Schooler J., Siddiqui S., Shanbhag S., Bernstein G., Horvai A., Majumdar S., Ries M., Li X.: Bone and Cartilage Demonstrate Changes Localized to Bone Marrow Edema- like Lesions within Osteoarthritic Knees. Osteoarthritis and Cartilage; Epub 28 Sept 2012. PMCID: PMC3538951 13. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S.: Multi-center precision of cortical and trabecular bone quality measures assessed by HR-pQCT. Journal of Bone and Mineral Research; Epub 16 Oct 2012. PMCID: PMC3577969 14. Tjong W, Nirody J, Carballido-Gamio J, Burghardt AJ, Kazakia GJ: Structural analysis of cortical porosity applied to HR-pQCT data. Medical Physics; in print. 15. Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch J, Link TM, Feeley B, Ma CB: The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone; in print.

D. Research Support

ACTIVE

K01AR056734 (Kazakia) 02/01/2009 – 6/30/2014 (NCE) NIH/NIAMS In vivo imaging of cortical porosity in the peripheral skeleton Objective: To investigate the structure of cortical porosity using in vivo high-resolution peripheral quantitative computed tomography (HR-pQCT), and specifically 1) to develop tools for the identification and structural characterization of cortical macro-porosity in HR-pQCT images, and 2) to utilize these tools to investigate the incidence, progression, and consequence of cortical macro-porosity in human subjects.

Kazakia GJ Page 6 R03AR064004 (Kazakia) NIH/NIAMS Visualizing Cortical Pore Space Constituents Objective: To determine cortical bone pore space contents by ex vivo histology combined with HR-pQCT and MR imaging in cadaver specimens.

R01 (Lotz) NIH/NIAMS Phenotypes of Pathologic Vertebral Endplate Degeneration Objective: To investigate the relationship between vertebral disc degeneration and vertebral bone and marrow pathology. Role: Co-Investigator

VA Program Project Award 1/1/12-12/31/15 Veterans Administration Mechanisms underlying hormonal regulation of fracture repair Goals of the three projects are to investigate: 1) The role of IGF-1 signaling in bone fracture repair (PI: Daniel Bikle, M.D. Ph.D.), 2) The role of the calcium-sensing receptor in the callus in fracture repair (PI: Dolores Shoback, M.D.), and 3) Targeting inhibitors of bone formation to promote fracture repair (PI: Robert Nissenson, Ph.D.). Role: Advisor

Obesity Pilot and Feasibility Award (Anne Schafer, MD) 10/11/2012-06/30/2014 UCSF Diabetes Center Marrow fat, bone mineral density, and body composition during gastric bypass-induced weight loss Objective: To measure the bone marrow fat, the fat content of pores in cortical bone, and fat-related hormones in a subset of an established, actively-enrolling cohort study of the effects of gastric bypass surgery on calcium metabolism and the skeleton. Role: Co-Investigator

Core Exploratory Award (Amanda Hutton-Parrott, DPT NP) 12/01/2012 - 1/31/2014 (NCE) UCSF Resource Allocation Program Effects of Exercise on Bone Quality and Bone Strength in HIV + Individuals Age 50 and Older Objective: To pilot the use of HR-pQCT in the assessment of bone quality changes in HIV with and without an exercise intervention. Role: Co-Investigator

Seed Grant Proposal 13-12 (Kazakia) 11/01/2013 - 10/31/2014 Department of Radiology and Biomedical Imaging Association of Hepatitis C Virus Infection with Reduced Bone Quality Objective: To pilot the use of HR-pQCT in the assessment of bone quality changes in HCV infected subjects. These funds are limited to use for scanner recharge and patient reimbursement only.

COMPLETED

Pilot Funding #08-03 (Kazakia / Xiaojuan Li, PhD) 1/26/09-1/26/10 UCSF Department of Radiology & Biomedical Imaging Multi-modality Imaging of Bone Marrow Edema-like Lesions in Osteoarthritis Role: Co-Principal Investigator

Individual Investigator Grant (Kazakia) 7/27/09-7/26/11 UCSF Academic Senate Committee on Research The Influence of Non-weight Bearing on Bone Structure and Strength

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE LANG, THOMAS F Professor in Residence University of California, San Francisco eRA COMMONS USER NAME (agency login) TFLANG

EDUCATION/TRAINING

(Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) INSTITUTION AND LOCATION DEGREE MM/YYYY FIELD OF STUDY (if applicable) University of Chicago BACHELOR OF ARTS 06/1983 Chemistry

University of California, Berkeley DOCTOR OF PHILOSOPHY 08/1990 Chemistry

University of California, San Francisco Postdoctoral Fellow 08/1992 Nuclear Medicine Imaging

A. PERSONAL STATEMENT

My primary research interests are the application of non-invasive imaging, in particular CT and PET, to study the morphological and functional alterations of the musculoskeletal system related to osteoporosis and sarcopenia. Over the last 15 years my laboratory has pioneered the use of volumetric quantitative computed tomography for studies of bone and muscle in large scale epidemiologic studies and clinical trials. Over the past two years, my group has pioneered the application of Voxel-Based Morphometry (VBM) to the study of proximal femoral structure, resulting in several publications listed below. As shown in our list of publications, we also have carried out exercise studies, including development of a new exercise system combining balance and resistance training modalities, that are directly relevant to the mission of the Physical Therapy Department.

B. POSITIONS AND HONORS

Positions and Employment

2007 - Professor in Residence, University of California, San Francisco 2003 - 2007 Associate Professor in Residence, University of California, San Francisco 2000 - 2003 Associate Adjunct Professor, University of California, San Francisco 1994 - 2000 Assistant Adjunct Professor, University of California, San Francisco 1992 - 1994 Medical Physicist, ADAC Laboratories

Other Experience and Professional Memberships

2013 - Associate Editor, Journal of Bone and Mineral Research 2013 - Faculty Advisor, Office of Ethics and Compliance, University of California, San Francisco 2010 - Distinguished Editor, NIH DCTS Clinical Translational Study Section 2010 - Chairman, Chancellor's Conflict of Interest Advisory Committee, University of California, San Francisco 2010 - 2012 Editorial Board Member, Journal of Bone and Mineral Research 2009 - 2013 Member, NIH CSR SBSR Study Section 2008 - 2012 Musculoskeletal Alterations Team Leader, National Space Biomedical Research Institute 2002 - 2010 Member, Chancellor's Conflict of Interest Advisory Committee, University of California, San Francisco 1994 - Member, American Society of Bone and Mineral Research

Honors

2014 Fellow, American Institute of Medical and Biological Engineering 2013 Distinguished Investigator Award, Academy of Radiology Research 2013 International Space Station Top Discoveries Award, NASA/American Astronautical Society 2013 Osteoporosis International Citation Award, Osteoporosis International 2004 Visiting Professor, Faculty of Medicine, University of Buenos Aires 1996 Young Investigator Award, World Congress of Osteoporosis

C. SELECTED PEER-REVIEWED PUBLICATIONS

Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR. Spatial Heterogeneity in the Response of the Proximal Femur to Two Lower-Body Resistance Exercise Regimens. J Bone Miner Res. 2013 Nov 30;PubMed PMID: 24293094. Keyak JH, Sigurdsson S, Karlsdottir GS, Oskarsdottir D, Sigmarsdottir A, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Lang TF. Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study. Bone. 2013 Nov;57(1):18- 29. PubMed PMID: 23907032; PubMed Central PMCID: PMC3786229. Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ 3rd, Keyak JH, Gudnason V, Khosla S, Harris TB, Lang TF. Structural patterns of the proximal femur in relation to age and hip fracture risk in women. Bone. 2013 Nov;57(1):290-9. PubMed PMID: 23981658; PubMed Central PMCID: PMC3809121. Leblanc A, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Spector E, Ploutz- Snyder R, Sibonga J, Keyak J, Nakamura T, Kohri K, Ohshima H. Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight. Osteoporos Int. 2013 Jul;24(7):2105-14. PubMed PMID: 23334732. Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ 3rd, Keyak J, Gudnason V, Khosla S, Harris TB, Lang TF. Proximal femoral density distribution and structure in relation to age and hip fracture risk in women. J Bone Miner Res. 2013 Mar;28(3):537-46. PubMed PMID: 23109068; PubMed Central PMCID: PMC3578081. Walker MD, Saeed I, McMahon DJ, Udesky J, Liu G, Lang T, Bilezikian JP. Volumetric bone mineral density at the spine and hip in Chinese American and White women. Osteoporos Int. 2012 Oct;23(10):2499-506. PubMed PMID: 22147209; PubMed Central PMCID: PMC3552556. Liu CT, Karasik D, Zhou Y, Hsu YH, Genant HK, Broe KE, Lang TF, Samelson EJ, Demissie S, Bouxsein ML, Cupples LA, Kiel DP. Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study. J Bone Miner Res. 2012 Apr;27(4):954-8. PubMed PMID: 22222934; PubMed Central PMCID: PMC3375687. Lang TF, Sigurdsson S, Karlsdottir G, Oskarsdottir D, Sigmarsdottir A, Chengshi J, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Keyak JH. Age-related loss of proximal femoral strength in elderly men and women: the Age Gene/Environment Susceptibility Study--Reykjavik. Bone. 2012 Mar;50(3):743-8. PubMed PMID: 22178403; PubMed Central PMCID: PMC3278586. Harnish R, Streeper T, Saeed I, Schreck C, Dannoon S, Slater J, Blecha J, VanBrocklin H, Hernandez-Pampaloni M, Hawkins R, Seo Y, Sayre G, Lang T. Quantification of Changes in Skeletal Muscle Amino Acid Kinetics in Adult Humans in Response to Exercise via Positron-emission Tomography with L-[methyl-11C] methionine. J Mol Imag Dynamic. 2012 January; 2(103). Streeper T, Cavanagh P, Hanson A, Dana C, Saeed I, Kornak J, Frassetto L, Grodsinsky C, Funk J, Lee S, Spiering B, Bloomberg J, Mulavara A, Sibonga J, Lang T. Development of an integrated countermeasure device for use in long-duration spaceflight. Acta Astronauta. 2011; 68(11-12):2029-2037. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Rogers H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, Guo XE. Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. J Bone Miner Res. 2010 Oct;25(10):2229-38. PubMed PMID: 20499344; PubMed Central PMCID: PMC3128822. Eastell R, Lang T, Boonen S, Cummings S, Delmas PD, Cauley JA, Horowitz Z, Kerzberg E, Bianchi G, Kendler D, Leung P, Man Z, Mesenbrink P, Eriksen EF, Black DM, HORIZON Pivotal Fracture Trial. Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2010 Jul;21(7):1277-85. PubMed PMID: 19802508. Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe DR, Harris TB. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int. 2010 Apr;21(4):543-59. PubMed PMID: 19779761; PubMed Central PMCID: PMC2832869. Miller PD, Delmas PD, Lindsay R, Watts NB, Luckey M, Adachi J, Saag K, Greenspan SL, Seeman E, Boonen S, Meeves S, Lang TF, Bilezikian JP, Open-label Study to Determine How Prior Therapy with Alendronate or Risedronate in Postmenopausal Women with Osteoporosis Influences the Clinical Effectiveness of Teriparatide Investigators. Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronate. J Clin Endocrinol Metab. 2008 Oct;93(10):3785-93. PubMed PMID: 18682511. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ, PaTH Study Investigators. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003 Sep 25;349(13):1207-15. PubMed PMID: 14500804.

D. RESEARCH SUPPORT

Ongoing Research Support

R01 AR064140- 02, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 2013/08/01-2017/05/31 LANG, THOMAS F (PI) CT-based modeling to analyze variation in skeletal response to osteoporosis drugs Role: PI

NNJ11HE31A, Universities Space Research Association/NASA 2011/10/01-2015/09/30 LEBLANC, ADRIAN (PI) Bisphosphonate as a Countermeasure to Space Flight Induced Bone Loss Role: KP

R01 AR060700- 04, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 2011/08/01-2015/07/31 LANG, THOMAS F (PI) Bone quality by vQCT and HR-pQCT: translation to multi-center clinical research Role: PI

R01 DK 069350, NIH/NIDDK 2010/07/01-2015/06/30 BILIZEKIAN, JOHN (PI) Bone Properties in Hypoparathyroidism: Effects of PTH Role: KP

R21 AR062479- 02, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 2012/08/17-2014/06/30 LANG, THOMAS F (PI) PET/CT of skeletal muscle amino acid kinetics Role: PI

Completed Research Support

R01 AG029571- 04, National Institute on Aging (NIA) 2008/09/01-2013/05/31 LANG, THOMAS F (PI) The Proximal Femoral Musculature: A new Risk Factor for Hip Fracture Role: PI R01 AG028832- 05, National Institute on Aging (NIA) 2007/07/15-2013/04/30 LANG, THOMAS F (PI) Age-related changes in proximal femoral strength in men and women Role: PI

R21 AR055253- 02, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 2008/09/05-2011/08/31 LANG, THOMAS F (PI) Quantitative periprosthetic PET/CT Role: PI

R01 AR046197- 04, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 2001/04/01-2006/03/31 LANG, THOMAS F (PI) Race differences in hip strength, density and geometry Role: PI

R42 AR045713- 03, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 1999/01/01-2004/12/31 LANG, THOMAS F (PI) Precise 3D QCT to Monitor Osteoporosis Therapy Role: PI

1999/09/30-2000/09/29 R41 AR045713- 01A1, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) LANG, THOMAS F (PI) PRECISE 3-D QCT TO MONITOR OSTEOPOROSIS THERAPY Role: PI Program Director/Principal Investigator: Wanek

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Lee, Jeannette Q. Assistant Professor eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Santo Tomas, Manila, Philippines BS 1994 Physical Therapy Texas Woman’s University, Houston, TX MS 2001 Physical Therapy Texas Woman’s University, Houston, TX PhD 2006 Physical Therapy Manual Lymphatic Dr. Vodder School International, Stowe, VT Certificate 2010 Drainage/ Combined Decongestive Therapy

A. Personal Statement Dr. Lee teaches content in the evidence based practice course and content related to acute care and oncology. She received her entry-level PT degree from University of Santo Tomas, and a MS and PhD in Physical Therapy from Texas Woman’s University in 2006. She is a member of the American Physical Therapy Association (acute care, orthopedic, oncology sections); California Physical Therapy Association; and National Strengthening and Conditioning Association. Dr. Lee has participated in a number of continuing education activities, including: Management of Lower Extremity Lymphedema workshop, APTA combined sections meetings, Upper Extremity Lymphedema: the Art and Science of PT Interventions workshop, Dr. Vodder Manual Lymphatic Drainage/ Combined Decongestive Therapy certification, Acute Care: the Front Line workshop, Human Simulation: Effecting a Change in Paradigm for Acute Care Eduction, and End of Life Care: Isses of Living and Dying in Clinical Practice workshop.

Lee is a licensed physical therapist in the state of California since 2011 (#38298), Pennsylvania since 2007 (#PT018932), and Texas since 2001 (#1145100). Additionally, she has Certification in Manual Lymphatic Drainage/ Combined Decongestive Therapy. Most recently, Lee was a Staff Physical Therapist at UPMC Hamot Medical Center in Erie, PA (2007-2011). Additionally, she was a Staff Physical Therapist at Memorial Hermann Hospital in Houston, TX, a Senior Physical Therapist at SPRINT Sports Rehabilitation in Pasig City, Philippines and a Staff Physical Therapist at the University of Santo Tomas in Manila, Philippines.

Lee’s research interests are primarily in oncology rehabilitation, particularly in the role of exercise and activity in patients who have cancer, and/or cancer-related sequalae, such as lymphedema. She has published and presented in this area at both local and national conferences. Ongoing research activities include analysis of physical performance and self-report data collected on a cohort of patients with advanced metastatic cancer participating in different modes of exercise, and evaluating the effects of an exercise program for women during or after breast cancer treatment who are at risk for developing lymphedema.

Lee is a member of the APTA and the National Strengthening and Conditioning Association. Within the APTA, she serves the Oncology section, currently as Vice President of the Section and as Section Delegate to the House of Delegates of the APTA. In this capacity, she assisted the section with strategic planning efforts and planning national educational program offerings. She is also on the Editorial Board of the Rehabilitation Oncology Journal. Within the program, Lee serves on the Curriculum Committee and participates in the admissions process and advises pre-PT students. Within the community, she consults and works pro bono as a physical therapist educator and clinician with a number of non-profit organizations, including Clinic by the Bay and Project Medishare for Haiti. Both groups seek to provide healthcare to underserved areas locally and internationally, the former to uninsured working residents from various neighborhoods in San Francisco and Daly City; the latter to patients in Hospital Bernard Mevs, the only critical care trauma and rehabilitation hospital in Port au Prince, Haiti.

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Wanek

Lee incorporates firm expectations of student performance with a flexible learning approach that takes into considerations students’ different individual learning styles. Her goal is to create a safe, open learning environment, and to be open to diverse points of view. Lee uses various avenues of instruction, ranging from classroom lectures, small group discussions, projects, practical exams, clinical simulations, expert guest lecturers, and real-life patient interactions/experiences. Student evaluations of Lee’s performance have been very high. She is cited as being very helpful and available to students. She offers compelling lectures and provides effective feedback to students. B. Positions and Honors Principal Positions Held Dates Institution and Location Title Faculty Rank Tenure Status 2011 – San Francisco State University, San Assistant Assistant Tenure track present Francisco, CA Professor Professor Adjunct Gannon University, Physical Assistant Non-tenure 2011 Assistant Therapy Program, Erie, PA Professor track Professor 2007- Gannon University, Physical Assistant Assistant Non-tenure 2011 Therapy Program, Erie, PA Professor Professor track Per Diem 2007- UPMC Hamot Medical Center, Erie, Physical N/A N/A 2011 PA Therapist Supplemental 2006- Memorial Hermann Hospital, Physical N/A N/A 2007 Houston, TX Therapist Supplemental 2003- Texas Woman’s University, School Learning Lab N/A N/A 2006 of Physical Therapy, Houston, TX Coordinator Graduate 1999- Texas Woman’s University, School Teaching N/A N/A 2002 of Physical Therapy, Houston, TX Assistant Graduate 2000- Texas Woman’s University, School Research N/A N/A 2001 of Physical Therapy, Houston, TX Assistant Senior 1998- SPRINT Sports Rehabilitation physical N/A N/A 1999 Center, Pasig City, Philippines therapist University of Santo Tomas Hospital, 1996- Chief physical Department of Rehabilitation, N/A N/A 1998 therapist Manila, Philippines University of Santo Tomas Hospital, 1994- Staff physical Department of Rehabilitation, N/A N/A 1996 therapist Manila, Philippines

Other Positions Held Concurrently

Honors Awards Texas Woman’s University Pioneer Proud Outstanding Staff Award, 2005 TWU Staff Scholarship, 2005, 2006 Jacqueline Niehuss Scholarship, 2005 Betty Reynolds Anderson Scholarship, 2004-05 Irene Bollier Memorial Scholarship, 2004-05

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: Wanek Sheila Kellagher Scholarship, 2003-04 Tom and Tillie McDonald Scholarship, 2002-03 American Physical Therapy Association Oncology Section Outstanding Student Research Award, 2002 Pauline Terrell Scholarship, 2000-01 Graduated cum laude, BS in Physical Therapy, 1994

Memberships American Physical Therapy Association Orthopedic section member: 1999 – present Oncology section member: 2000 – present Vice President: 2012 – present Secretary: 2010 – 2012 Editorial Board, Rehabilitation Oncology: 2009 – present Programming committee member: 2009 – present Chair, Nominating committee: 2008 – 2009 Nominating committee member: 2007 – 2008 Pennsylvania Physical Therapy Association Secretary, Northwest chapter: 2009 – 2011 Member: 2007 – 2011 Texas Physical Therapy Association Member: 1999 – 2007 National Strengthening and Conditioning Association Certified Strengthening and Conditioning Specialist: 2000 – present C. Peer-Reviewed Publications Shelton ML, Lee JQ, Morris GS, Massey PR, Kendall DG, Anderson KO, Bartlett WP, Simmonds MJ, Giralt SA. Comparison of a home versus a supervised exercise program for stem cell transplant patients: a randomized controlled trial. Psychooncology. 2009; 18(4):353-9.

LeeJQ, Bartlett WP, Simmonds MJ, Olson SL, Anderson KA, Roddey TR. Activity and sleep characteristics in recent allogeneic bone marrow transplant patients participating in exercise. Rehab Oncology. 2007; 25(1):24.

Lee JQ, Simmonds MJ, Wang XS, Novy DM. Differences in physical performance between men and women with and without lymphoma. Arch Phys Med Rehabil 2003; 84:1747- 52.

D. Research Support Completed Research Support

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE LEVINE, Jon David Professor eRA COMMONS USER NAME jonlevine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Michigan BS 1966 Biophysics Yale University PhD 1972 Neuroscience University of California at San Francisco MD 1978 Medicine A. Personal Statement I have employed a multidisciplinary approach — molecular, biochemical, in vitro and in vivo electrophysiological, behavioral and clinical — to evaluate mechanisms underlying pain, analgesia and inflammatory states. I have extensive expertise in investigating signal transduction mechanisms for mechanical, neuropathic and generalized pain, thermal and chemical stimulus-induced activation of sensory neurons and mechanisms underlying sensitization of responses to these stimuli. I have described a novel transducer mechanism for thermal stimuli, and the role of a second messenger, the epsilon isoform of PKC (PKCε), in mediating nociceptor sensitization and the role it plays the transition from acute to chronic pain. I have employed a variety of pain models, including neuropathic pain (e.g. diabetic- and chemotherapy-induced neuropathy), as well as ergonomic musculoskeletal pain associated with vibration exposure and eccentric exercise including the role of stress in chronic musculoskeletal pain. I have also investigated neural and endocrine contributions to pain and inflammation as well as sexually dimorphic mechanisms in pain, analgesia and inflammation. B. Positions and Honors. Vice Chair Department of Oral and Maxillofacial Surgery 2005-present Professor of Divisions of Rheumatology and Clinical Immunology, and Experimental 1993-Present Medicine Therapeutics, Dept. of Anatomy and Oral and Maxillofacial Surgery, UCSF Member Program in Biomedical Sciences, UCSF 1992-Present Assoc. Prof. Divisions of Rheumatology and Clinical Immunology, and Experimental 1989-93 Medicine Therapeutics, Dept of Anatomy and Oral and Maxillofacial Surgery, UCSF Member Division of Neurobiology, UCSF 1987-Present Assist. Prof. Divisions of Rheumatology and Clinical Immunology, and Experimental 1983-89 Medicine Therapeutics, Dept. of Anatomy and Oral and Maxillofacial Surgery, UCSF Instructor in Department of Physiology, UCSF 1981-1983 Residence Guest Investigator, ARC Muscle Mechanisms Unit, Oxford University 1968 Chancellor's Commendation for Research Excellence, University of California 1978 Hartford Foundation Fellow 1984-1987 Most Important New Research in Rheumatic Diseases, Annual NIH Report to Congress 1985 Member, American Association of Professors 2000 Rita Allen Foundation Fellow 1988-1993 Young Investigator Award, International Association for the Study of Pain 1990 Frederick J. Kerr award, American Pain Society 2002

C. Selected peer-reviewed publications (in chronological order). (Selected from over 350 publications) 1. Hucho, T. B., Dina, O. A., Kuhn, J., and Levine, J. D. Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons. Eur J Neurosci 2006; 24:527-534. 2. Khasar, S. G., Burkham, J., Dina, O. A., Brown, A. S., Bogen, O., Alessandri-Haber, N., Green, P. G., Reichling, D. B., and Levine, J. D. Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain. J Neurosci 2008; 28:5721-5730. PMC2518401 3. Khasar, S. G., Dina, O. A., Green, P. G., and Levine, J. D. Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines. J Pain 2009; 10:1073- 1077. PMC2757466 4. Joseph, E. K., and Levine, J. D. Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. Neuroscience 2010; 169:431-435. PMC2903040 5. Ferrari, L. F., Bogen, O., and Levine, J. D. Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience 2010; 165:896-901. PMC2815163 6. Dina, O. A., Levine, J. D., and Green, P. G. Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress. Eur J Pain 2011; 15:796–800. PMC3123688 7. Joseph, E. K., Gear, R. W., and Levine, J. D. Mechanical stimulation enhances endothelin-1 hyperalgesia. Neuroscience 2011; 178:189-195. PMC3049981 8. Chu, C., Levine, E., Gear, R. W., Bogen, O., and Levine, J. D. Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia. Pain 2011; 152:1832-1837. PMC3161405 9. Ferrari, L. F., Chum, A., Bogen, O., Reichling, D. B., and Levine, J. D. Role of drp1, a key mitochondrial fission protein, in neuropathic pain. J Neurosci 2011; 31:11404-11410. PMC3157245 10. Bogen, O., Alessandri-Haber, N., Chu, C., Gear, R. W., and Levine, J. D. Generation of a pain memory in the primary afferent nociceptor triggered by PKCepsilon activation of CPEB. J Neurosci 2012; 32:2018-2026. PMC3305286 11. Alvarez, P., Gear, R. W., Green, P. G., and Levine, J. D. IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Exp Neurol 2012; 233:859-865. PMC3272112 12. Joseph, E. K., and Levine, J. D. Sexual dimorphism in endothelin-1 induced mechanical hyperalgesia in the rat. Exp Neurol 2012; 233:505-512. NIHMS342702 13. Ferrari, L. F., Levine, E., and Levine, J. D. Role of a novel nociceptor autocrine mechanism in chronic pain. Eur J Neurosci 2013; 14. Joseph, E. K., and Levine, J. D. Role of endothelial cells in antihyperalgesia induced by a triptan and beta- blocker. Neuroscience 2013; 232:83-89. NIHMS430242 15. Joseph, E. K., Green, P. G., Bogen, O., Alvarez, P., and Levine, J. D. Vascular endothelial cells mediate mechanical stimulation-induced enhancement of endothelin hyperalgesia via activation of P2X2/3 receptors on nociceptors. J Neurosci 2013; 33:2849-2859. D. Research Support. Ongoing Research Support

1 R01 AR063312 Levine (PI) 03/05/13 – 02/28/2018 $416,274/year Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor Mechanisms This study will investigate the nociceptor as a primary site at which activation of neuroendocrine stress axes contributes to chronic pain.

R01 AR048821 Levine (PI) 07/01/02 – 08/31/2014 (will not be renewed) $203,148 Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome

The goal of the project is to characterize the vagotomy-based model of generalized hyperalgesia, and to use this model to elucidate mechanisms underlying chronic generalized pain. To provide important new insights into the pathophysiology of generalized pain conditions, including that associated with fibromyalgia.

1R01NS084545-01A1 Levine (PI) Impact score: 17/Percentile: 3.0 Nociceptor mechanisms in the transition from acute to chronic pain The project is focused on the understanding of acute-to-chronic pain at the level of the peripheral nociceptor, and potential prevention and reversal of such enhanced pain states.

Pending Research Support

R01 (PA-13-302) Levine (PI) 07/01/14 – 06/30/2019 $450,134/year Ectopic Uterine Tissue as a Pain Generator In our proposed study, we will employing a novel model of endometriosis, to evaluate pain by direct stimulation of an endometrial lesion, the site from which the pain inducing signal is generated and record sensory neuron activity that arises from the sensory innervation of the ectopic endometrium. Base on our findings we will conduct interventions to evaluate peripheral mechanisms underlying endometriosis pain. Role: PI

*R01 (PA-13-302) Levine (PI) 07/01/14 – 06/30/2019 $459,946/year Vascular Pain Mechanisms In our proposed study of the role of endothelin and the endothelium in vascular pain, we will perform behavioral, pharmacological and biochemical/molecular studies. Role: PI

Completed Research Support

1 R01AA017384 Levine (PI) 09/15/08 – 05/31/2013 $214,107 Mechanisms of Interactions of Alcohol Abuse HIV Neuropathogenesis The goal of the project has been to investigate the cellular mechanisms by which consumed alcohol aggravates antiretroviral-induced neuropathic pain. Role: PI

R01 DE018526 Levine (PI) 08/01/07 – 07/31/2013 $360,272/year Modeling Kappa Opioid Analgesic Mechanisms in Chronic Orofacial Pain Disorders The goal of this project was to study the mechanisms underlying the sexual dimorphism in the analgesic effect of kappa-opioids for acute and chronic pain syndromes.

1R01 AR054635 Levine (PI) 08/01/07 – 07/31/2013 $208,593/year Mechanisms and Risk Factors in Musculoskeletal Pain The goal of this project was to study the mechanisms underlying acute muscle pain and its transition to chronic pain, using ergonomic models of muscle pain.

P01 NS053709 Levine (PI) 09/01/07 – 06/30/2013 $755,893/year Receptors and Second Messengers for Pain and Analgesia The goal of this project was to study the role of PKCε, a Ca++-independent novel protein kinase C isoform in nociceptor function, including in the transition from acute to chronic pain 1-4. These studies will be completed prior to the proposed start date of this grant application. In the current grant application, we propose to develop the next phase of our research on the role of PKCε in acute and chronic pain, in a R01 format. Thus,

the proposed research has no redundancy with any grant that will be active when the present grant application would start. Role: Director/PI

Itzhak Perlman Grant Div. Rheumatology 01/01/13 – 06/30/2013 $25,639/year Stress and Musculoskeletal Ergonomic Function Role: Co-PI

1 R01 AR052106 Levine (PI) 05/16/06 – 02/28/2012 $186,528/year Sex dimorphism in neuroendocrine control of inflammation The goal of this study has been to study the roles of gonadal hormones, the sympathoadrenal axis, and control of sympathoadrenal axis by stress and by vagal afferent activity in the sexually dimorphic modulation of here principal components of the inflammatory response: plasma extravasation, leukocyte accumulation, and hyperalgesia. Role: PI

1 R01 NS053880 Levine (PI) 05/17/06 – 02/28/2011 $225,000/year Integrin family of proteins in acute and chronic pain The goal of this project was to study interdisciplinary approach utilizing behavioral and electrophysiological methods in concert to pharmacologically dissect apart the differential roles of individual integrin subunits in the acute and chronic hyperalgesia and nociceptor hyperexcitability that occurs in both inflammatory and neuropathic pain states. Role: PI

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Xiaojuan Li Associate Professor eRA COMMONS USER NAME XIAOJUAN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Tsinghua University B.S. 1996/06 Biomedical Engineering Tsinghua University M.S. 1999/06 Biomedical Engineering University of California, Berkeley and San Francisco Ph.D. 2003/12 Bioengineering

A. Personal Statement My current research program aims at developing advanced and quantitative imaging techniques, and evaluating their clinical significance for musculoskeletal diseases including arthritis and osteoporosis. I have extensive experience in developing advanced MRI and high field NMR techniques for cartilage, bone, fat and synovial fluid quantification. I have also fostered close collaborations with clinicians to apply these advanced techniques to clinical applications. I have established collaboration with various faculty in the Department of Physical Therapy and Rehabilitation Science and look forward to mentoring students in the proposed PhD program in Rehabilitation Science.

B. Positions and Honors. Positions and Employment 2004-2006 Assistant Research Scientist, Department of Radiology, University of California at San Francisco (UCSF) 2006-2010 Assistant Professor, Musculoskeletal Quantitative Imaging Research group (MQIR) Department of Radiology and Biomedical, UCSF Department of Orthopaedic Surgery (joint faculty appointment) 2010-Present Associate Professor, Musculoskeletal Quantitative Imaging Research group (MQIR) Department of Radiology and Biomedical Imaging, UCSF Department of Orthopaedic Surgery (joint faculty appointment) 2006-Present Member, Joint Bioengineering Graduate Program, UC Berkeley and UCSF Professional Memberships 1998-Present Institute of Electrical and Electronics Engineers (IEEE) 2000-Present International Society of Magn. Reson. in Medicine (ISMRM) 2006-Present Orthopaedic Research Society (ORS) 2006-Present Osteoarthritis Research Society International (OARSI) 2009-Present American College of Rheumatology (ACR) Honors 1992-95, 1997 Tsinghua Outstanding Student Scholarship 1999 Tsinghua Honored Graduate Student 1999-2000 Regents Fellowship, University of California at Berkeley 2001/02/03 Student Conference Travel Award, ISMRM 2006 Orthopaedic Research Society New Investigator Recognition Award finalist 2006 NIH Mentored Quantitative Research Career Development Award 2007 Outstanding Paper Award, 2007 Inter. Osteoporosis Conference – Bone and Joint Decade, Beijing, China 2008 Young Investigator, 2008 AAOS/ORS Research Symposium (AICKH) 2011 Editor Awards (corresponding author), Skeletal Radiology 2012 Distinguished Reviewer, MRM 2012 2012 JOSPT George J. Davies - James A. Gould Excellence in Clinical Inquiry Award (Co-author)

C. Selected peer-reviewed publications (selected from more than 80 in chronological order). 1. Li X, Han ET, Ma CB, Link TM, Newitt DC, Majumdar S, “In Vivo 3T Spiral Imaging Based Multi-slice T1ρ Mapping of Knee Cartilage in Osteoarthritis”, Magn. Reson. Med, 54(4): 929-936, 2005. 2. Li X, Ma B, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S, In vivo T1rho and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 Tesla MRI, Osteoarthritis and Cartilage, 15(7): 789-97, 2007. 3. Li X, Han ET, Busse RF, Majumar S, In vivo T1rho mapping in cartilage using 3D magnetization- prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS), Magn Reson Med, 59(2):298-307, 2008. PMCID: 18228578. 4. Li X, Ma CB, Bolbos RI, Stahl R, Lozano J, Zuo J, Lin K, Link TM, Safran M, Majumdar S, Quantitative assessment of bone marrow edema pattern and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging, J. Magn Reson Imaging, Aug;28(2):453-61, 2008. PMCID: 18666183. 5. Bolbos RI, Zuo J, Banerjee S, Link TM, Ma CB Li X, Majumdar S, Relationship between trabecular bone and articular cartilage T1ρ and T2 relaxation times, thickness and volume of the knee joint in early OA using parallel MRI at 3T. Osteoarthritis and Cartilage, 16(10):1150-9, 2008. PMCID: 18387828. 6. Bolbos RI, Ma CB, Link TM, Majumdar S, Li X, In vivo T1ρ quantitative assessment of knee cartilage after anterior cruciate ligament (ACL) injury using 3T MRI, Invest Radiol 43(11):782-8, 2008. PMCID: 18923257) 7. Li X, Pai A, Blumenkrantz G, Carballido-Gamio J, Link TM, Ma CB, Ries MD, Majumdar S, Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis, Magn Reson Med 61(6):1310-8, 2009. 8. Taylor C, Carballido-Gamio J, Majumdar S, Li X, Comparison of quantitative imaging of cartilage for osteoarthritis: T2, T1rho, dGEMRIC, and contrast-enhanced CT, Magn Reson Imag., 27(6):779-84, 2009. PMID: 19269769 9. Zhao J, Li X, Link TM, Bolbos R, Majumdar S, Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3T MR T1rho quantification, Musculoskeletal Radiology, 2010 Mar 1. [Epub ahead of print]. PMID: 20195865. 10. Theologis, AA, Kuo D, Cheng J, Bolbos RI, Carballido-Gamio J, Ma CB, Li X, Evaluation of bone bruises and associated cartilage in ACL inured knees using quantitative T1rho MRI: one-year cohort study, Arthroscopy, 27(1): 65-76, 2011. PMCID: PMC3011041. 11. Li X, Kuo D, Theologis AA, Carballido-Gamio J, Stehling C, Link TM, Ma CB, Majumdar S, MRI T1rho and T2 of cartilage in anterior cruciate ligament-injured and reconstructed knees: initial experience with one-year follow-up, Radiology, 2011 Feb;258(2):505-14. PMID: 21177392. 12. Tang SY, Souza RB, Ries M, Hansma PK, Alliston T, Li X, Local Tissue Properties of Human Osteoarthritic Cartilage Correlate with Magnetic Resonance T1rho Relaxation Times, J Orthop Res. 2011 Sep;29(9):1312-9. PMID: 21445940. 13. Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV, Quantification of Vertebral Bone Marrow Fat Content using 3 Tesla MR spectroscopy: Reproducibility, Vertebral Variation and Applications in Osteoporosis, J Magn Reson Imag, 2011 Apr;33(4):974-9. PMID: 21448966. 14. Theologis AA, Haughom B, Liang F, Zhang Y, Majumdar S, Link TM, Ma CB, Li X. Comparison of T1rho relaxation times between ACL-reconstructed knees and contralateral uninjured knees. Knee Surg Sports Traumatol Arthrosc. 2013 Jan 31. PMID: 23370983. 15. Souza RB, Feeley BT, Zarins ZA, Link TM, Li X, Majumdar S. T1rho MRI relaxation in knee OA subjects with varying sizes of cartilage lesions. Knee. 2013 Mar; 20(2):113-9. PMID: 2315971. D. Research Support Active

NIH/NIAMS R01 AR057819 PI: Li, X and Schwartz, A 4/1/2010-3/31/2013 Bone Marrow Adiposity, Bone and Body Composition The goals of this study are to measure bone marrow adiposity using MR spectroscopy and to explore the relationship between marrow fat, bone parameters and other fat depots in a cohort of older adults. Role: Principal Investigator

NIH/HIAMS P50AR060752 (Majumdar/Lane) 04/01/2011 – 03/31/2016 Translation of Quantitative Imaging in Osteoarthritis The overall objective of this proposal is to integrate cutting edge, quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. Research Project 2: Quantitative MRI and Gait Analysis for ACL-injured and Reconstructed Knees (Li/Ma) Role: Project Leader Core B: Imaging and Data Analysis Core (IDAC) (Li/McCulloch) Role: Core Leader

NIH/NIAMS R01AR046905-11A1 (Majumdar) 06/20/2011 – 05/31/2016 Loaded and Unloaded MR Imaging of Meniscus-Cartilage-Trabecular Bone in OA This study will develop non invasive biomarkers for cartilage and meniscus degeneration in the knee.We will also examine differences in these tissues with loading. This will help individuals who have or are at risk for deveolping osteo-arthritis. Role: Co-investigator

NIH/NIDDKR01DK08921601 (Schwarz, Lustig) 7/1/2010 – 6/30/2015 UCSF subcontract; PI Noworolski Pediatric Fructose Restriction: Reducing Co-morbidity The goals of this grant are to assess the effects on metabolism of reducing fructose intake in an obese pediatric population. Role: Subcontract Co-investigator

Completed

NIH/NIAMS K25 AR053633 PI: Li, X 04/01/2006-03/31/2012 Early detection of cartilage degeneration using high field MRI The goals of this project are to develop imaging techniques at 3T for detecting cartilage degeneration at early stages and to evaluate the techniques in patients with osteroarthritis and ACL-injuries. Role: Principal Investigator

NIH/NIAMS R21 AR056773-01A1 PI: Li, X 9/1/2009-8/31/2012 NMR spectral markers of cartilage degeneration in osteoarthritis The goal of this study is to evaluate biochemical changes in osteoarthritic cartilage using high- resolution magic angle spinning (HRMAS) NMR techniques. Role: Principal Investigator

Roche Laboratories PICS Black, D (PI) 3/27/2008-12/31/2012 PTH and Ibandronate Combination Study (PICS) The overall goals of PICS are to examine two different ways of combining Parathyroid Hormone (PTH) and antiresorptive therapy (ibandronate for this study) to see if we can optimize the increase in bone density and strength. Role: Co-investigator

NIH/NIAMS K25 AR053633 Supplement PI: Li, X 09/15/2009-09/14/2011 Early detection of cartilage degeneration using high field MRI Role: Principal Investigator

Aircast Foundation #S0505R Li, X (PI) 08/01/2006-07/31/2008 Assessment of Cartilage and Subchondral Bone Injuries of the Knee Following Anterior Cruciate Ligament Tear with High Field Magnetic Resonance Imaging The goals of this project are to evaluate cartilage and bone injuries using MRI and MR spectroscopic imaging techniques at 3T for patients with ACL tears. Role: Principal Investigator

NIH R01 HL075675 Havel, P (PI) (UC Davis) 07/01/2005-06/30/2006 Effects of consumption of high sugar beverages with meals for 10 weeks on hormones and lipids The goal of this subcontract is to measure intromycellular lipids using MR spectroscopic imaging method. Role: Principal Investigator of subcontract to UC Davis

GlaxoSmithKline Link, T (PI) 12/1/2005-6/30/2007 New MRI parameters to study Cartilage Matrix in Patients with Osteoarthritis The goal of this grant is to use new MRI parameters such as T1rho measurements, T2 relaxation time measurements and cartilage volumetric assessment to characterize cartilage matrix in patients with early and advanced osteoarthritis as well as normal volunteers. Role: Co-investigator

UC Discovery Grant BIO07-10641 Majumdar, S (PI) 2/1/2008 – 1/31/2010 Non-Invasive Biomarkers Of Disc Degeneration Researchers at UCSF have recently identified chemical features of painful discs that are measurable using high strength MR technology. Nocimed has licensed this technology and is developing the hardware and software to allow these chemical features to be measured painlessly in back pain patients. Role: Co-investigator

American Orthopaedic Society for Sports Medicine Ma, B (PI) 01/01/07 - 12/31/08 Evaluation of the Treatment of Articular Cartilage Injuries using Quantitative MR Imaging The goal of this study is to study the treatment of articular cartilage in a rabbit model. Role: Co-investigator

UCSF REAC Li, X (PI) 11/1/2007-10/31/2009 Quantitative assessment of bone marrow edema pattern in osteoarthritic and ACL-injured knees. The goal of this study is to quantify water and lipids changes in BMEP using 3D MRSI and to quantify perfusion using dynamic enhanced MRI. Role: Principal Investigator

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Thomas M. Link Prof. in Residence; Chief, Musculoskeletal Radiology and Clinical Director, Musculoskeletal & Quantitative Imaging eRA COMMONS USER NAME (credential, e.g., agency login) Research Group, Department of Radiology and Biomedical LINKTHOMAS Imaging, UCSF EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

University of Mainz, Germany MD 11/1986 Medicine University of Muenster, Germany PhD 11/1997 Radiology

A. Personal Statement Over the last 20 years I have acquired extensive research and clinical experience in imaging of the musculoskeletal system in particular of bone and cartilage. Our research group aims to develop the best possible tools to diagnose and monitor osteoarthritis; a particular focus of my research work has been to identify the impact of modifiable risk factors of osteoarthritis, which include physical activity, obesity and muscle strength. I am currently the Clinical Director of the Musculoskeletal and Quantitative Imaging Research group at UCSF. In this role I mentor numerous emerging scientists, some medical students, PhD students, postdocs, and residents. Many of our research projects have included strong collaborations with faculty in the Department of Physical Therapy and Rehabilitation Science. As such, I would be delighted to continue our collaborations as the Department of Physical Therapy begins a new PhD in Rehabilitation Science program, and I am looking forward to mentor PhD students in this program.

B. Positions and Honors Positions and Employment 1987 - 1988 Resident, Department of Radiology, Center for Rheumatic diseases of the State of Rheinland- Pfalz, Bad Keuznach, Germany 1988 – 1991 Resident, Department of Radiology, City Hospital Luedenscheid, Teaching Hospital of the University of Bonn, Germany 1991 – 1993 Resident, Department of Radiology, University of Muenster, Germany 1993 – 1995 Staff Radiologist, Department of Radiology, University of Muenster, Germany 1996 Research Fellow, Department of Radiology, UCSF, San Francisco 1997 – 2000 Attending Radiologist and Associate Professor, University of Muenster, Germany 1999 – 2001 Visiting Associate Professor, Department of Radiology, UCSF, San Francisco 2000 – 2003 Vice Chairman and Associate Professor, Technische Universitaet of Munich, Germany 2003 - present Professor of Radiology, Technische Universitaet of Munich, Germany 2003 - 2007 Associate Professor in Residence, Department of Radiology, UCSF 2003 - present Clinical Director Musculoskeletal and Quantitative Imaging Research, UCSF 2007 - present Professor of Radiology, Department of Radiology, UCSF 2008 - present Chief, Musculoskeletal Radiology

Honors and Awards 1997 Caffey Award of the Society of Pediatric Radiology 2000 Award for the best teaching course for medical students at the Medical School of the Technische Universitaet of Munich 2000-2003 Elected Member of the Editorial Board of European Radiology 2003 Award for best scientific exhibit at the European Congress of Radiology “cum laude”

2003 Professor of Radiology, Technische Universitaet of Munich, Germany, title awarded one year earlier due to outstanding research and academic qualifications 2003 Elected member, International Skeletal Society 2004-2007 Section Editor Musculoskeletal Radiology for European Radiology since 2006 Chairman of the Osteoporosis Group of the ESSR 2007 Editor’s Recognition Award 2006, European Journal of Radiology 2008 Editor’s Recognition Award 2007, European Journal of Radiology 2008 Editor’s Recognition Award 2008 with distinction, Radiology 2008 Elected Member Editorial Board Osteoarthritis and Cartilage 2009 Elected Member Editorial Board European Radiology 2009 Top Cited Award 2006-2008 - Osteoarthritis and Cartilage 2009 The Founder’s Lecturer of the International Skeletal Society, Washington 2010 Editor’s Recognition Award 2010 with special distinction, Radiology 2011 Editors Award, Skeletal Radiology 2011 Editor’s Recognition Award 2011 with distinction, Radiology 2011 Editorial Board Skeletal Radioloy 2011 Certificate of Distinction, Skeletal Radiology 2012 Editor’s Recognition Award 2012 with distinction, Radiology 2012 George J. Davies – James A. Gould, Excellence in Clinical Inquiry Award

C. Selected Peer-reviewed Publications (Selected from 300 peer-reviewed publications) 1. Link, TM, Steinbach, L, Ghosh, S, Ries, M, Lu, Y, Lane, N and Majumdar, S. MR-Findings in Different Stages of Osteoarthritis and Correlation with Clinical Findings. Radiology, 226: 373-81, 2003. 2. Link, TM, Koppers, BB, Licht, T, Bauer, J, Lu, Y and Rummeny, EJ. In Vitro and in Vivo Spiral CT to Determine Bone Mineral Density: Initial Experience in Patients at Risk for Osteoporosis. Radiology 231: 805- 811, 2004. 3. Hudelmaier, M, Kollstedt, A, Lochmuller, EM, Kuhn, V, Eckstein, F, Link, TM. Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence. Osteoporos Int. 2005 Sep;16(9):1124-33. 4. Link TM, Sell CA, Masi JN, Phan C, Newitt D, Lu Y, Steinbach L, Majumdar S. 3.0 vs 1.5T MRI in the detection of focal cartilage pathology - ROC analysis in an experimental model. Osteoarthritis Cartilage. 2006 Jan;14(1):63-70. 5. Bauer JS, Krause SJ, Ross CJ, Krug R, Carballido-Gamio J, Ozhinsky E, Majumdar S, Link TM. Volumetric Cartilage Measurements of Porcine Knee at 1.5-T and 3.0-T MR Imaging: Evaluation of Precision and Accuracy. Radiology. 2006 Nov;241(2):399-406. 6. Bauer JS, Henning TD, Mueller D, Lu Y, Majumdar S, Link TM. Volumetric quantitative CT of the spine and hip derived from contrast-enhanced MDCT: conversion factors. AJR 2007; 188(5): 1294-301. 7. Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM. MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthritis Cartilage. 2007; 15(11): 1225- 34. PMC Journal - In Process 8. Huber MB, Carballido-Gamio J, Bauer JS, Baum T, Eckstein F, Lochmüller EM, Majumdar S, Link TM. Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT-- correlation with biomechanical strength measurement. Radiology. 2008; 247(2):472-81. 9. Rauscher I, Stahl R, Cheng J, Li X, Huber MB, Luke A, Majumdar S, Link TM. Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthritis. Radiology. 2008; 249(2): 591- 600. PMCID 2657859 10. Diederichs G, Link TM, Kentenich M, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Rogalla P, Issever AS. Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing. Bone. 2009; 44(5): 976-83. PMC Journal - In Process. PMID: 19442610 11. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May;25(5):983-93. PMID: 1988

12. Stehling C, Liebl H, Krug R, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology. 2010 Feb;254(2):509-20. PMCID: PMC2809928 13. Hovis KK, Stehling C, Souza RB, Haughom BD, Baum T, Nevitt M, McCulloch C, Lynch JA, Link TM. Physical activity is associated with MR-based knee cartilage T2 measurements in asymptomatic subjects with and without osteoarthritis risk factors. Arthritis Rheum. 2011 2011 Aug;63(8):2248-56. 14. Jungmann PM, Kraus MS, Alizai H, Nardo L, Baum T, Nevitt MC, McCulloch CE, Joseph GB, Lynch JA, Link TM. Metabolic risk factors are associated with cartilage degradation assessed by T2 relaxation time at the knee. Arthritis Care Res (Hoboken). 2013 Aug 7. doi: 10.1002/acr.22093. [Epub ahead of print] PMID: 2392602715. 15. Lin W, Alizai H, Joseph GB, Srikhum W, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Physical activity in relation to knee cartilage T2 progression measured with 3 Tesla MRI over a period of 4 years: Data from the Osteoarthritis initiative. Osteoarthritis Cartilage. 2013 Jul 3. doi:pii: S1063-4584(13)00858-3.

D. Research Support

Ongoing Research Support

T32EB001631-06 Link (PI) 07/01/10-06/30/15 NIH Biomedical imaging for clinician scientists The goal of this grant is to establish a structured intensive one year training program in Biomedical Imaging based in the Department of Radiology at UCSF. The program will be open to Radiology residents who are in or have completed training. The primary long term objective of this training program is to produce a cadre of academic radiologists who will become leaders in Biomedical Imaging, and help address the current lack of such clinical scientific investigators. Role: Co-Investigator, Associate Director

BAA-NHLBI-AR-10-06 Nevitt (PI) 06/01/10 – 05/31/15 NHLBI Hip Morphology and Limb-specific Risk Factors for Radiographic Hip Osteoarthritis Research concerns the identification and validation of risk factors for knee and hip OA and the evaluation of novel and efficient tools for analysis of x-rays that can be applied to large numbers of images with high degrees of reproducibility Role: Co-Investigator

1U01AR059507 - 01 Link (PI) 07/01/10-06/30/14 NIAMS/NIH T2 Relaxation Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort The aim of this project is to study whether T2 relaxation time measurements of the cartilage can be used as a sensitive measure to predict degeneration of the knee joint in individuals from the osteoarthritis incidence cohort with different levels of physical activity.

P50 AR060752 Majumdar/Lane (PI) 08/01/2011- 07/31/2016 NIH/NIAMS Translation of Quantitative Imaging in Osteoarthritis The overall objective of this proposal is to integrate cutting edge, quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. Role: Co-Investigator and PI subproject 3, Cartilage T2 Relaxation Time in the OAI normal, incidence and progression cohorts

2R01 AR046905-11A1 Majumdar (PI) 06/20/2011 – 05/31/2016 NIH/NIAMS

Loaded and Unloaded MR Imaging of Meniscus-Cartilage-Trabecular Bone in OA This study will develop non invasive biomarkers for cartilage and meniscus degeneration in the knee. We will also examine differences in these tissues with loading. This will help individuals who have or are at risk for developing osteoarthritis.

Completed Research Support

1RC1AR058405-01, NIH Link (PI) 09/30/09 – 08/31/12* Cortical Bone Porosity Identifies Diabetes Subjects with Fragility Fractures The major goal of this grant is to study cortical and trabecular bone architecture in diabetes subjects with and without osteoporotic fractures and to compare these findings to those in normal subjects and osteoporotic fracture subjects. *NCE from 09/01/11-08/31/12

R01 AG017762, PAR-04-023, NIH Majumdar (PI) 07/01/08 - 06/30/12 Bioengineering Research Partnership: Morphological and Functional Imaging of the Musculoskeletal System In response to PAR-04-023, participants from the University of California San Francisco (UCSF),University of California Berkeley (UCB), Massachusetts general Hospital (MGH) and industry (General Electric, GE) propose a competing renewal of a Bioengineering Research Partnership (BRP) focused on the systematic study of the morphology and function of the musculoskeletal system in disease and health. We hypothesize that high field (3 Tesla and 7 Tesla), high resolution, fast MR combined with quantitative tissue assessment, would significantly impact the clinical assessment of musculo-skeletal degeneration and reparative processes, spanning a range of scales, from the tissue to the whole organ. The long-term vision of this partnership is to understand the link between morphology, function and clinical symptoms, with a specific focus on osteoporosis, osteoarthritis and degenerative disc disease. Role: Co-investigator

R01 AR46905-01, NIH Majumdar (PI) 04/19/06 – 01/31/12* Cartilage Bone Interactions in Osteoarthritis *NCE from 2/1/11-1/31/12 The major goals of this project are to study whether MR parameters may be used as better surrogate markers for osteoarthritis disease progression than standard conventional radiographs. Role: Co-Investigator

1R21AR055253, NIH Lang (PI) 09/05/08-08/31/11* Quantitative Periprosthetic PET/CT * NCE from 9/1/10-8/31/11 Develop method for quantitative uptake measurements for PET/CT around prostheses by correcting CT attenuation maps for metal artifacts Role: Co-Investigator

AO Foundation, Davos, Switzerland, Subcontract Link (PI) 04/01/2006 – 03/31/10 Fracture Fixation in Osteoporotic Bone: Project X-ray/CT based analysis of trabecular bone texture The major goals of this project are to develop structure analysis techniques in conventional radiographs and CT images of the proximal femur to assess fracture risk and predict loosening of total hip prostheses. Role: Principal Investigator

BIO07 – 10641, UC Discovery Grant-Biotechnology Majumdar (PI) 02/01/2008 – 01/31/2010 Non-Invasive Biomarkers Of Disc Degeneration Researchers at UCSF have recently identified chemical features of painful discs that are measurable using high strength magnetic resonance technology. Nocimed has licensed this technology and is developing the hardware and software to allow these chemical features to be measured painlessly in back pain patients. If successful, this technology will revolutionize the way physicians diagnose and treat low back pain. Role: Co-Investigator

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE LIU, JIALING Professor of Neurosurgery (UCSF) eRA COMMONS USER NAME Research Career Scientist (VA) JAILING EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) National Taiwan University B.A. 1984 Medical Science Boston University Medical Center Ph.D. 1992 Immunology University of California, San Francisco, CA Postdoctoral 1992-1996 Neurology fellow

A. Personal statement I have a longstanding interest in brain injury, regeneration and functional recovery for the last 12 years here at UCSF. I am the scientific director of the Neurobehavioral Core at the San Francisco VA medical center, and a member of the Brain and Spine Injury Center (BASIC) and the Cerebrovascular Research Program at UCSF. I routinely train my colleagues and their lab personnel in behavioral assays and provide consultation in study design and data analysis, as well as interpretation. The generous support from NIH, VA, AHA and DoD over the years has not only expanded my research program, but also given me an opportunity in training pre-doctoral students and postdoctoral fellows. Many of them have either continued their pursuit in medical research or even assumed faculty positions in various academic institutes. I have also participated in teaching in the Neuroscience Graduate Program and the Biomedical Graduate Program and coaching journal club presentations. In addition, I also teach in the neuroscience course and research conference of the neurosurgery residents.

Time and effort statement: Research, 80%; Teaching/mentoring, 10%; Administration, 10%

B. Positions, Honors and Professional Experience 1986- 1992 Research assistant and Ph.D. student, Boston University Medical Center, Mass. 1992- 1996 Postdoctoral fellow, Neurology, UCSF 1996- 1998 Postgraduate researcher, Neurology, UCSF 1998- 1999 Assistant research neuroscientist, Neurology, UCSF 1999- 2001 Assistant Research Scientist, Neurological Surgery, UCSF and NCIRE 2001- 2005 Assistant Professor, Neurological Surgery, UCSF and NCIRE 2005- 2011 Associate Professor, Neurological Surgery, UCSF and NCIRE 2011- p Professor, Neurological Surgery, UCSF and NCIRE

2002-2005 Member, AHA Brain 2 study section 2004- p Member, AHA Western Affiliate study section 2007-p Editorial Board of Stroke 2007-p NIH CSR ETTN-C11B (BDCN-A11) study section 2007 Ad hoc DoD PTSD/TBI Concept Award Reviewer Panel #4 2007 Ad hoc DoD PTSD/TBI Intramural Program Review Panel #2 2007 Ad hoc NIH ZRG1 MDCN-B study section 2008 Ad hoc NIH CSR NT-B study section 2008 Ad hoc NIH CSR BINP study section 2008 Ad hoc DoD deployment related medical research program in PTSD/TBI, Advanced Technology/Therapeutic development ATTDC panel #5 2008 Ad hoc DoD deployment related medical research program in PTSD/TBI, Hypothesis development panel #3

2008 Ad hoc NIH CSR NT-B study section 2009 Ad hoc DoD PH/TBI Concepts #2 peer review panel 2009 Ad hoc NIH ZRG1 MDCN-P study section 2009-p Brain Injury and Stroke VA Merit Review Panel RR&D 2009- 2014 Career scientist award from VA BLR&D

Princeton Conference (2000, 2004, 2006). Ad hoc reviewer for Trends in Neuroscience (TINS), PNAS, J Neuroscience, Ann Neurology, FASEB, Stroke, Glia, Journal of Cerebral Blood Flow and Metabolism, Neurobiology of Disease, Neuroscience, E J. Neuroscience, J Neurotrauma, Experimental Neurology, J Neuroscience Methods, J Neuroscience Res., Developmental Biology, Neuroscience Letters, Neuroreport and Brain Research. Translational Stroke Research.

C. Selected Publications

Most recent publications

1. TI Lam, D Bingham, TJ Chang, CC Lee, J Shi,, D Wang , S Massa, RA. Swanson and J Liu. Beneficial effects of minocycline and modified constraint physical therapy following experimental TBI. Neurorehabilitation and Neural Repair 27:889-899, 2013. PMID: 23778701 2. CL Hsieh, CC Kim, BE Ryba, EC Niemi, JK Bando, RM Locksley, J Liu, MC Nakamura, and WE Seaman. Traumatic brain injury induces unique macrophage subsets and CCR2-dependent cognitive impairment. Eur. J. Immunol. 43(8): 2010-22, 2013. PMID: 23630120 3. C Sun, H Sun, S Wu, CC Lee, Y Akamatsu, RK Wang, SG Kernie and J Liu. Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of post-stroke cognitive function and reduces synaptic connectivity in the perforant pathway. J Neuroscience 33:17314-25, 2013. 4. J Liu, Y Wang, Y Akamatsu, CC Lee, MT Lawton and GY Yang. Vascular remodeling after stroke: mechanisms and therapeutic potentials. Progress in Neurobiology doi: 10.1016/ j.pneurobio. 2013.11.004. [Epub ahead of print]. PMID: 24291532

Other relevant publications (brain injury, functional recovery, regeneration) 1. Liu J, K Solway, RO Messing, and FR Sharp. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neuroscience 18:7768-7778, 1998. 2. Raber J, Y Fang, Y Matsumori, P.R. Weinstein, JR. Fike and J. Liu. Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann. Neurology 55: 381-9, 2004. 3. Schmitt-Ulms G, K Hansen, J Liu, C Cowdrey, J Yang, SJ DeArmond, FE Cohen, SB Prusiner and MA Baldwin. In vivo analysis of protein interactions involving the prion protein using time-controlled transcardiac perfusion crosslinking. Nature Biotechnology 22:724-731, 2004. 4. Suh SW, F. Yang, MS Hong, Y Matsumori, PR Weinstein, RA Swanson and J Liu. Hypoglycemia induces neuronal regeneration and progenitor cell loss in the rat dentate gyrus. Diabetes 54:500-9, 2005. 5. Matsumori Y, MS Hong, K Aoyama, Y Fan, T Kayama, AR Sheldon, ZS Vexler, DM Ferriero, PR Weinstein and J Liu. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J. Cere. Blood Flow & Metabolism 25:899-910, 2005. 6. Matsumori Y, FJ Northington, MS. Hong, Y Fan, T Kayama, AR Sheldon, ZS Vexler, DM Ferriero, PR Weinstein and J Liu. Reduction of Caspase-8, 9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice over- expressing Hsp70. Stroke 37:507-12, 2006. 7. Matsumori Y, MS Hong, Y Fan, T Kayama, C Hsu, PR Weinstein and J Liu. Enriched environment and spatial learning enhances hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiology of Disease 22:187-98, 2006. 8. Liu ZY, F Yang, SJ Won, M Neumann, DZ Hu, L Zhou, PR Weinstein, and J Liu. Chronic treatment of minocycline preserves newborn neurons and reduces functional impairment after focal cerebral ischemia. Stroke 38: 146-52, 2007.

9. Fan Y, PR Weinstein, JR Fike and J Liu. Environmental Enrichment Enhances Neurogenesis and Improves Functional Outcome after Cranial Irradiation. Eur. J. Neurosci.. 25:38-46, 2007. 10. SM Hong, Y Fan, M Neumann, SJ Won, D Lac, X Lum, PR Weinstein, and J Liu. Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Exp. Neurology 206: 24-32, 2007. 11. Rapp J, X Pan, M Neumann, SM Hong, K Hollenbeck and J Liu. Microemboli composed of cholesterol disrupt blood brain barrier and reduce cognitive function in aged rats. Stroke 39: 2354-61, 2008. 12. Wang Y, SM Hong, B Bontempi, PR Weinstein, GM Abrams and J Liu. Environmental enrichment reduces gait impairment after experimental stroke. J Cere. Blood Flow & Meta. 28:1936-50, 2008. 13. Suh, SW, SJ Won, AM Hamby, Y Fan, CT Sheline, H Tamano, A Takeda and J Liu. Decreased zinc availability reduces hippocampal neurogenesis in mice and rats. J Cere. Blood Flow & Meta. 29: 1579-88, 2009. 14. Sun H, T Le, A Habib, TJ Chang, S Wu, F Shen, WL Young, H Su and J Liu. AAV-mediated Netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke Neurobiol Dis. 44:73-83, 2011. 15. Wang Y, M Neumann, K Hansen, SM Hong, S Kim, LJ Noble-Haeusslein and J Liu. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma 28(2):259-68, 2011.

D. Research Support.

On-going Projects Title: Neuroplasticity after experimental stroke Agency: NIH NINDS RO1 NS071050-01A1 (Liu) Period: 5/1/2011-4/30/2016 The goal of this study is to investigate whether constraint induced movement therapy reduces hippocampal hypofunction induced by experimental stroke.

Title: The recovery of post stroke mild cognitive impairment: an experimental model Agency: American Heart Association (National EIA 0940065N) (Liu) Period: 4/01/09-6/30/14 The goal of this proposal is to study the underlying mechanism for post stroke MCI and functional recovery.

Title: Mechanisms underlying Netrin-1-mediated functional recovery after stroke Agency: Department of Veterans Affairs RehabR&D, I01RX000655 Investigator initiated award (Liu) Period: 4/1/12-3/31/16 The goal of this study is to investigate the beneficial effects of Netrin-1 in reducing inflammation and in enhancing plasticity during rehabilitation.

Title: Multimodal strategies for improving recovery from brain injury Agency: Department of Veterans Affairs, RehabR&D REAP (Swanson) Role: co-investigator Period: 7/01/09-6/30/14 The goal of this research enhancement award is to investigate the combined effect of small molecule neurotrophin, anti-inflammatory agent and constraint-induced therapy on functional recovery of stroke and TBI.

Title: Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Agency: Department of Veterans Affairs, BLR&D Merit Review IO1BX001960-01 (Chang) Role: co-investigator Period: 4/1/2013- 1/31/2017 The goal of this proposal is to study the interplay of CaSR and GABA-B-R1 following ischemic brain injury.

Completed Projects.

Title: The role of microglial subsets in regulating traumatic brain injury Agency: Department of defense, intramural program (Seaman) Role: collaborator Period: 12/01/08-11/30/12 The goal of this proposal is to study role of M2 microglia in mediating brain inflammation after traumatic brain injury and the treatment effect of PPARg and TREM2 agonists given post TBI.

Title: Reducing functional deficits following traumatic brain injury Agency: Department of Veterans Affairs, BLR&D (Liu) Period: 10/1/07-9/30/11 The goal of this proposal is to study how cognitive therapy promotes memory function and how new neurons are recruited during memory acquisition and recall.

Title: Micro-atheroemboli and small artery disease of the brain Agency: Department of Veterans Affairs, BLR&D (Rapp) Role: co-investigator Period: 10/01/07-09/30/11 The goal of this proposal is to study the effect of micro-atheroemboli on brain injury and small artery disease

Title: A potential compound to protect against damage from TBI Agency: Department of defense W81XWH-05-2 (Simpson) Role: co-investigator Period: 1/01/10-12/31/11 The goal of this proposal is to search compounds that will proactively protect against neurological damage caused by TBI by targeting the Alpha-1-adrenergic receptors.

Overlap: None

Program Director/Principal Investigator: Luke

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Luke, Anthony, Cho-Chak Professor of Clinical Orthopaedic Surgery eRA COMMONS USER NAME (credential, e.g., agency login) LUKEA1

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Studies in Faculty of Arts Univ. of Toronto, Toronto, Ontario, Canada B.A. 06/91 & Science Univ. of Toronto, Toronto, Ontario, Canada M.D. 06/95 Doctor of Medicine St. Joseph's Health Care Centre Resident 06/97 Family Practice Primary Care Sports Harvard University, Boston, MA Fellowship 06/99 Med Program in Clinical Harvard University, Boston, MA 06/99 Effectivenes s Harvard University, Boston, MA Masters 06/00 Public Health

A. Personal Statement For the Department of Orthopedic Surgery, I am Director of Primary Care Sports Medicine and the Director of the UCSF Human Performance Center (HPC). My experience in clinical sports medicine, public health, activity promotion, exercise testing, biomechanics, and clinical research have allowed me to build a cutting edge center for UCSF at the Mission Bay campus. The goal of the HPC is to promote the highest level of clinical care and research in the areas of Orthopaedics, Sports Medicine and Performing arts by focusing on preventive care and optimization of human performance. I have developed programs to complement our clinical sports medicine services and research studies with Biomechanical testing and Exercise physiology measurements. Many students are able to learn through the lab and our HPC staff assist faculty to add biomechanical or exercise physiology outcomes to their studies. From 2012 to 2013, the lab has conducted over 556 biomechanical studies. The HPC has 6 research students including 1 PhD candidate; 2 Post Doctoral staff in Physical therapy; 4 physical therapy students; 2 achelor Degree students. The HPC also is a local educational resource for the community. The goal of financial sustainability of the lab will be met through clinical services and research grants. At present the RunSafe program and exercise testing provide direct income to the Center and Department. The HPC is part of an accepted NIH core P50 grant where 2 out of 4 project involve biomechanics testing. HPC research projects include several PENDING R01 submissions. My own research involves biomechanical assessment and have had NIH-CTSI funding. I am also working with industry start-ups who have been interested in product testing and development using our expertise and equipment. We are working with local start ups to perform product testing or preliminary validation studies with different technologies such as testing algorithms in self-monitoring devices. I have a broad background in clinical sports medicine and non-operative treatment of sports injuries. I can also help enroll patients through my busy clinical practice and the high schools we work with. My research work includes clinical evaluation of athletes in particular runners with 2D and 3D analysis. My research has included work with the Musucloskeletal and Quantitative Image Research group with several publications coming from work on knee osteoarthritis, runners and articular cartilage changes using advanced MRI techniques. This includes MRI techniques similar to this proposal on young healthy marathon runners which has been published in the American Journal of Sports Medicine. For training I have completed the Clinical Effectiveness program and Masters of Public Health at Harvard. I have successfully completed studies for

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Luke

publication as well as lead position statements with groups of writers involved in large sports organizations. I have experience organizing and directing various staff to accomplish research goals and writing projects. Because of my contacts through previous work experience at University of Western Ontario and as a fellow of the American College of Sports Medicine, I have good network contacts in other large biomechanics labs. In summary, I have demonstrated a record for clinical research projects, have recruitment opportunities in my busy clinical practice and experience organizing projects. I have supervised PhD level students in the past at University of Western Ontario and peripherally at UCSF. I have supervised research and mentored many premedical, medical, residents and fellows over the years. As the Department of Physical Therapy and Rehabilitation proposes a new PhD program in Rehab Science, I offer my full support and would be happy to mentor students in this program. B. Positions and Honors Principals Positions Held 2012 present University of California, San Professor of Clinical Department of Orthopaedic Francisco Orthopaedics Surgery

2012 present University of California, San Joint Appointment Department of Family and Francisco Professor Community Medicine

Other Positions Held Concurrently

Honors Awards 2001 Alice G. Brandfonbrener Young Investigator Award 2002 NETWORK Research Award 2005 2005 Clinical Teaching Award, Awarded by UCSF Graduating Class to 5 best teachers, University of California, San Francisco 2006 New Investigator Research Award (NIRA), Orthopaedic Research Foundation, Quantitative Cartilage Imaging of Knee Osteoarthritis - An In Vivo Comparison between T1p and T2 mapping using 3T MRI, Li, X; Link, T M; Ma, C B; Blumenkrantz, G; Lozano J; Luke A; Majumdar S. 2011 SF Business Times Health Care Heroes Finalist San Francisco Business Times 2013 UCSF Exceptional Physician Award University of California, San Francisco

Memberships 1996 present Canadian Academy of Sports & Exercise Medicine (CASEM) 2000 present International Federation of Sports Medicine (FIMS) 2004 present Member, American Medical Society for Sports Medicine (AMSSM) 2005 present Fellow, American College of Sports Medicine

Service to Professional Organizations 2001 present CASM Research Committee Member 2006 2013 ACSM Fit Society Editorial Board Member 2006 present California Interscholastic Federation of High Schools, Sports Member Medicine Committee 2007 2010 ACSM Research Committee Member 2008 present ACSM Strategic Health Initiative for Youth Health and Sports Chair (reappointed for 2nd term starting 2011) 2013 present Current Sports Medicine Reports Reviewer C. Selected Peer-Reviewed Publications 1. Luke A, Malthaner R, Winton T. Case Report of a Patient with an Extrapulmonary Arteriovenous Fistula. PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: Luke

University of Toronto Medical Journal (Feature Article), 1994, 71:3:6-9. 2. Chitayat D, Hodgkinson K, Luke A, Winsor E, Rose T, Kalousek D. Prenatal Diagnosis and Fetopathological Findings in Five Fetuses with Trisomy 9. Am J Med Genet, 1995, 56: 247-251. 3. Micheli LJ, Luke AC, Mintzer CM, Waters PM. Elbow arthroscopy in the pediatric and adolescent population. Arthroscopy 2001 Sep;17(7):694-699. 4. Kocher MS, Micheli LJ, Zurakowski D, Luke A. Partial tears of the anterior cruciate ligament in children and adolescents. Am J Sports Med. 2002; 30(5): 697-703. 5. Luke A, Kinney S, D'Hemecourt PD, Baum J, Owen M, Micheli LJ. Determinants of Injuries in Young Dancers. Medical Problems of Performing Artists, 2002; 17:3: 105-112. 6. Luke A, Philpott J, Brett K, Cruz L, Lun V, Prasad N, Zetaruk M. Physical Inactivity in Children and Adolescents. Clin J Sport Med, 2004; 14: 5: 260-266. 7. Bergeron MF, McKeag DB, Casa DJ, Clarkson PM, Dick RW, Eichner ER, Horswill CA, Luke AC, Mueller F, Munce TA, Roberts WO, Rowland TW. Youth football: Heat stress and injury risk. Med Sci Sports Exerc, 2005; 37(8):1421-30. 8. Luke A, Ma CB. Case Report: Exertional thigh pain in a runner. Curr Sports Med Rep, 2006; 5(5): 251- 253. 9. Iyengar J, Luke A, Ma CB. Case Report: An unusual presentation of synovial chondromatosis. Clin J Sport Med, 2007;17(2):157-9. 10. Luke AC, D'Hemecourt PA. Prevention of infectious diseases in athletes. In: Best T, Borchers J (eds) Clin Sports Med, 2007; 26 (3): 321-344. 11. Luke AC, Bergeron M, Roberts WO. Survey on heat injury prevention practices in American football programs. Clin J Sport Med, 2007; 17:488-493. 12. Stahl R, Luke AC, Ma CB, Krug R, Steinbach L, Majumdar S, Link TM. Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison to physically active subjects - a 3.0 Tesla MRI study with optimized cartilage imaging. Skeletal Radiology, 2008, 37(7):627-38. 13. Rauscher I, Stahl R, Cheng J, Li X, Huber MB, Luke A, Majumdar S, Link TM. Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthritis. Radiology, 2008; 249(2): 591- 600. 14. Stahl R, Luke A, Li X, Carballido-Gamio J, Ma CB, Majumdar S, Link TM. T1rho, T(2) and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients-a 3.0-Tesla MRI study. Eur Radiol. 2009 Jan;19(1):132-43. 15. Philpott JF, Wilson E, Luke AC. The Importance of Exercise: Know How to Say Go. Pediatr Ann. 2010 Mar;39(3):162-4, 166-8, 171. PMID: 20302248 16. Philpott JF, Luke AC, Houghton K. Physical Activity Recommendations for Children with Chronic Health Conditions: Juvenile Idiopathic Arthritis, Hemophilia, Asthma, Cystic Fibrosis. Joint position statement for the Canadian Academy of Sport Medicine and the Canadian Pediatric Society. Clin J Sport Med, 2010; 20:3: 167- 172. (Joint position statement by the Canadian Academy of Sports Medicine and the Canadian Pediatric Society for publication). 17. Philpott JF, Luke AC, Houghton K. Physical Activity Recommendations for Children with Chronic Health Conditions: Juvenile Idiopathic Arthritis, Hemophilia, Asthma, Cystic Fibrosis. Joint position statement for the Canadian Academy of Sport Medicine and the Canadian Pediatric Society. Paediatr Child Health, 2010; 15:4: 213-218, 219-225 (in French). (Joint position statement by the Canadian Academy of Sports Medicine and the Canadian Pediatric Society for publication). 18. Luke AC, Stehling C, Stahl R, Li X, Kay T, Takamoto S, Ma, CB Majumdar S, Link T. High Field MRI assessment of articular cartilage before and after marathon running: Does long-distance running lead to cartilage damage? Am J Sports Med, 2010; 38(11): 2273-80. PMID: 20631252. 19. Stehling C, Luke A, Stahl R, Baum T, Joseph G, Pan J, Link TM. Meniscal T1rho and T2 measured with 3.0T MRI increases directly after running a marathon. Skeletal Radiol, 2011; 40:6: 725-735. PMID: 21052658. 20. Luke AC, Lazaro RM, Bergeron MF, Keyser L, Benjamin H, Brenner J, d’Hemecourt PA, Grady M, Philpott J, Smith A. Sports-related injuries in youth athletes: Is overscheduling a risk factor? Clin J Sport Med, 2011, 21(4):307-14. PMID: 21694586 21. Behera SK, Pattnaik T, Luke A. Practical Recommendations and Perspectives on Cardiac Screening for Healthy Pediatric Athletes. Current Sports Medicine Reports, 2011. 10(2): 90-98. PMID: 21623290. 22. Souza R, Fang C, Wu S, Luke A, Li X, Majumdar S. Relationship between Knee Kinetics during Jumping PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator: Luke

Tasks and Knee Articular Cartilage MRI T1rho and T2 Relaxation Times. Clin Biomech (Bristol, Avon), 2012; 27(4):403-408. PMID: 22115848. 23. D'hemecourt PA, Luke AC. Sport-Specific, Biomechanics of the Spinal Injuries in Aestehtic athletes (Dancers, Gymnasts, and Figure skaters). Clin Sports Med, 2012; 31(3): 397-408. PMID: 22657991. 24. Thuillier DU, Souza RB, Wu S, Luke A, Li X, Feeley BT. T1? imaging demonstrates early changes in the lateral patella in patients with patellofemoral pain and maltracking. Am J Sports Med. 2013 Aug; 41(8):1813-8. PMID: 23845401 25. Difiori JP, Benjamin HJ, Brenner J, Gregory A, Jayanthi N, Landry GL, Luke A. Overuse injuries and burnout in youth sports: a position statement from the american medical society for sports medicine. Clin J Sport Med. 2014 Jan; 24(1):3-20. PMID: 24366013 26. Souza RB, Hatamiya NS, Allen C, Aramaki A, Martinelli B, Wong J, Luke A. Medial and Lateral Heel Whips: Prevalence and Characteristics in Recreational Runners. Submitted to the Journal of Orthopedic and Sports Physical Therapy, 2013.

27. Kumar D, McDermott K, Feng H, Goldman V, Luke A, Souza RB, Hecht FM. Effect of a training in ChiRunning on running biomechanics: A pilot randomized trial in individuals with pre-hypertension(Submitted to Physical Medicine & Rehabilitation, 2014) D. Research Support On-going Research Support AR060752-01 Majumdar & Lane (PI) 07/01/2011 - 06/30/2016 Centers of Research Translation (CORT) NIH/ NIAMS – P50 Translation of Quantitative Imaging for Osteoarthritis (TOQIO) The goal of this program grant is to advance the field of quantitative imaging of osteoarthritis. It includes 3 cores and 4 independent research studies, which involve various aims from translating knee quantitative imaging to hip OA and investigating the biomechanics of post-traumatic OA following ACL-injury. Role:Co-Investigator 444530 Luke (PI) 09/01/2011 - 08/31/2016 Genzyme Sanofi Aventis Long-term Management of “Younger, Active” Patients with Pain from Early Knee Osteoarthritis with Synvisc- One (hylan G-F 20) This is a natural history cohort study investigating the benefits of Hylan G-F 20 injections as a means of reducing pain and maintaining physical activity levels in individuals with mild knee osteoarthritis in active patients 30-50 years of age. Role:Principal Investigator Completed Research Support Massachusett's Governing Committee on Physical Activity in Sports 09/01/2000 - 06/30/2001 Walnut Hill High School for the Arts / Children's Hospital of Boston, Natick, MA Prospective Pilot Study: Determinants of Injuries in Young Dancers; Article published in Medical Problems of Performing Artists, 2002; 17:3: 105-112. Role:PI 01/01/2007 - 05/30/2007 Canadian Academy of Sports Medicine Web-based International Survey of Health and Physical Activity Levels (WISHPAL) to assess the Effects of Socioeconomic Factors on Activity in High School Students; Investigate socioeconomic factors that influence sports participation using an internet-based survey; we hope to understand how socioeconomic status, culture, ethnicity, and other competing interests affect physical activity levels in high school students in the United States, Canada, and Switzerland. Manuscript in progress Role:PI UL1 RR024131 Luke (PI) 05/01/2011 - 06/30/2012

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator: Luke

CTSI T1 Catalyst Grant National Center for Research Resources (NCRRNIH/NCRR UCSF-CTSI) Validation of the RunSafe™ 2-Dimensional gait analysis method against the gold standard, 3-Dimensional gait analysis This project is to analyze the 2 dimensional (2D) video capture and compare the assessment to 3 dimensional (3D) running gait analysis in order to identify statistically relevant deviations in diagnosis between methods and understand biomechanical assessment of specific variables in the 2D running analysis. Role:PI 3202V1-1000 Ma (PI) 06/15/2009 - 12/31/2013 Wyeth Pharmaceuticals Outcomes of arthroscopic double row rotator cuff repair The major goals of this project are to study the outcomes of rotator cuff tear repairs; I will be performing the serial musculoskeletal ultrasounds on the shoulders to follow presence re-tearing Role:Co-Investigator

PHS 398/2590 (Rev. 06/09) Page 5 Biographical Sketch Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Ma, C. Benjamin Associate Professor In Residence eRA COMMONS USER NAME (credential, e.g., agency login) BENJMA

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

A. Personal Statement As a clinician/scientist, I have always been interested in improving patient care with joint problems. I am currently the Chief of the Sports Medicine and Shoulder Service at UCSF. My group has been actively involved in studies that allow early detection and improve treatment in joint injuries. I have been a PI of an OREF research grant, Cartilage initiative, AOSSM grants and a number of clinical trials. We have been actively looking at early radiologic markers to identify cartilage degeneration. The current proposal will allow us to study a common clinical problem and surgical procedure on meniscus injuries. The findings will be important to allow us to better manage our patients. I am in full support of the proposed PhD in Rehabilitation Science program and would be happy to mentor students with aligned research interests. B. Positions and Honors Principals Positions Held 2003 present University of California, San Assistant Professor Department of Orthopaedic Francisco In Residence Surgery 2007 present University of California, San Chief Sports Medicine and Francisco Shoulder Service 2009 present University of California, San Associate Professor Department of Orthopaedic Francisco In Residence Surgery

Other Positions Held Concurrently

Honors Awards 2002 Best Resident of the Year, UPMC Orthopaedics 2004 New Investigator Research Award, Orthopaedic Research Society, San Francisco 2005 UCSF Orthopaedic Surgery Teaching Award 2006 New Investigator Research Award Finalist, Co- investigator, Orthopaedic Research Society, Chicago 2006 Young Investigator Initiative Workshop Participant US Bone and Joint Decade 2008 Excellence in Teaching Award for Clinical Teaching Faculty UCSF School of Medicine, Class of 2008 2008 UCSF Exceptional Physician Award 2009 New Investigator Research Award, (Choongsoo Shin) Principle investigator: Ma CB Orthopaedic Research Society, Chicago 2009 Excellence in Patellofemoral ResearchPrinciple investigator: Ma CBISAKOS, Osaka, Japan 2011 Charles S Neer Award: American Shoulder and Elbow Society 2011 Henry Kaiser Award for Excellent in Teaching in the 2011 Ambulatory Care Setting, UCSF

2012 American Shoulder and Elbow Society 2013 Charles S Neer Award: American Shoulder and Elbow Society 2013 Orthopaedics Today: Top 19 US Sports Medicine Specialists 2013 Best Paper Award Shoulder Program. 12th International Congress for Shoulder and Elbow Surgery, Nagoya, Japan

Memberships

Service to Professional Organizations C. Selected Peer-Reviewed Publications 1. Ma CB, MacGillivray JD, Clabeaux J, Lee S, Otis J: Biomechanical Evaluation of an Arthroscopic Rotator Cuff Stitch - the Massive Cuff Stitch. Journal of Bone and Joint Surgery Am 2004 Jun 86-A (6):1211-6. 2. Ma CB, Comerford L, Wilson J, Puttlitz C: Biomechanical analysis of arthroscopic rotator cuff repairs - double row versus single row fixation. Journal of Bone and Joint Surgery 2006 Feb: 88(2): 403-10. 3. Kuhn JE, Dunn WR, Ma C, Wright RW, Jones G, Spencer EE, Wolf B, Safran M, Spindler KP, McCarty E, Kelly B, Holloway B: Interobserver agreement in the classification of rotator cuff tears. Am J Sports Med 2007 Mar; 35(3): 437-41. 4. Ma, CB; Kawamura, S; Deng, XH.; Ying L; SchneidkrautJ; Hays, P; Rodeo, SA : BMP-Signaling Plays a Role in Tendon-to-Bone Healing: A Study of rhBMP-2and Noggin. Am J Sports Medicine 2007 Apr 35(4): 597- 604. 5. Rodeo SA, Kawamura S, Ma CB, Deng XH, Sussman PS, Hays, P, Ying L:The effect of osteoclastic activity on tendon-to-bone healing: An experimental study in rabbits. J Bone and Joint Surgery 2007 Oct 89(10): 2250- 9. 6. Bolbos RI, Zuo J, Banerjee S, Cheng J, Link TM, Ma BC, Li X, Majumdar S.Interrelationship between trabecular bone and articular cartilage of the knee joint in early OA using parallel MRI at 3T. Osteoarthritis and Cartilage 2007 Dec 15: 168-169 7. Spencer EE Jr, Dunn WR, Wright RW, Wolf BR, Spindler KP, McCarty E, Ma CB, Jones G, Safran M, Holloway GB, Kuhn JE: Interobserver agreement in the classification of rotator cuff tears using magnetic resonance imaging. Am J Sports Med 2008 Jan 36(1): 99-103. 8. Lugo R, Krug P, Ma CB: Shoulder biomechanics European J Radiology 2008 Oct 68(1): 16-24. 9. Carpenter RD, Majumdar S, Ma CB: Magnetic resonance imaging of 3-dimensional in vivo tibiofemoral kinematics in anterior cruciate ligament- reconstructed knees. Arthroscopy 2009 Jul;25(7):760-6. 10. Holtzman DJ, Theologis AA, Carballido-Gamio J, Majumdar S, Li X, Ma CB: T1rho and T2 quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures. J Magn Reson Imaging� 2010 Oct: 32(4): 914-23. 11. Theologis AA, Kuo D, Cheng J, Bolbos RI, Carballido-Gamio J, Ma CB, Li X: Evaluation of Bone Bruises and Associated Cartilage in Anterior Cruciate Ligament-Injured and – Reconstructed Knees using Quantitative T1rho Magnetic Resonance Imaging: 1-year Cohort Study. Arthroscopy 2010 Jan 27 (1):65-76. Li X, Kuo D, Theologis A, Carballido-Gamio J, Stehling C, Link TM, Ma CB, Majumdar S: Cartilage in Anterior Cruciate Ligament-Reconstructed Knees: MR imaging T1rho and T2- initial experience with 1-year follow-up. Radiology 2010 Dec 21. 13. Haughom B, Schairer W, Souza RB, Carpenter D, Ma CB, Li X: Abnormal tibiofemoral kinematics following ACL reconstruction are associated with early cartilage matrix degeneration measured by MRI T1rho. Knee 2011, Jul 30 Epub ahead of print. 14. Schairer WW, Haughom BD, Morse LJ, Li X, Ma CB: Magnetic Resonance Imaging Evaluation of Knee Kinematics After Anterior Cruciate Ligament Reconstruction with Anteromedial and Transtibial Femoral Tunnel Drlling Techniques. Arthroscopy 2011 Dec; 27 (12): 163-70. 15. Borchers JR, Kaeding CC, Pedroza AD, Huston LJ, Spindler KP, Wright RW; on behalf of the MOON Consortium and MARS study groups. Intra-articular Findings in Primary and Revision Anterior Cruciate Ligament Reconstruction Surgery: A Comparison of the MOON and MARS study group. Am J Sports Med 2011 Sep; 39(9): 1889-1893. 16. Pinney JR, Taylor C, Doan R, Burghardt A, Li X, Kim HT, Ma CB, Majumdar S: Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magnetic Resonance Imaging [Epub] 2011 17. Theologis AA, Schairer WW, Carballido-Gamio J, Majumdar S, Li X, Ma CB: Longitudinal analysis of T1rho and T2 quantitative MRI of knee cartilage laminar organization following microfracture surgery. Knee 2011; Oct 20. [Epub ahead of print] 18. Jungmann PM, Li X, Nardo L, Subburaj K, Lin W, Ma CB, Majumdar S, Link TM. Do cartilage repair procedures prevent degenerative meniscus changes?: longitudinal t1? and morphological evaluation with 3.0-T MRI. Am J Sports Med. 2012 Dec; 40(12):2700-8. 19. Kothari A, Haughom B, Feeley B, Li X, Ma CB: Evaluating rotational kinematics of the knee in ACL reconstructed patients using 3.0 Tesla magnetic resonance imaging. Knee 2012 Jan 19 [Epub ahead of print] 20. Haughom BD, Souza R, Schairer WW, Li X, Ma CB: Evaluating rotational kinematics of the knee in ACL- ruptured and healthy patients using 3.0 Tesla magnetic resonance imaging. Knee Surg Sports Traumatology Arthroscopy 2012 Apr; 20 (4): 663-70. 21. Kim JM, Ma CB: Quantitative MRI of the ACL-injured and Reconstructed Knee. Clin Sports Med 2013 Jan; 32(1):21-36. 22. Theologis AA, Haughom B, Liang F, Zhang Y, Majumdar S, Link TM, Ma CB, Li X. Comparison of T1rho relaxation times between ACL-reconstructed knees and contralateral uninjured knees. Knee Surg Sports Traumatol Arthrosc. 2013 Jan 31. 23. Su F, Hilton JF, Nardo L, Wu S, Liang F, Link TM, Ma CB, Li, X. Cartilage morphology and T1rho and T2 quantification in ACL-reconstructed knees: A 2- year follow-up. Osteoarthritis Cartilage. 2013 Aug; 21 (8). PMID 23707754 24. Chen JL, Allen CR, Stephens TE, Haas AK, Huston LJ, Wright RW, Feeley BT, Multicenter ACL Revision Study (MARS) Group. Differences in Mechanisms of Failure, Intraoperative Findings and Surgical Characteristics Between Single- and Multiple-Revision ACL Reconstruction: A MARS Cohort Study. Am J Sports Med 2013 July 41 (7) PMID 23698386 D. Research Support On-going Research Support P50AR060752 (Majumdar/Lane) Ma (PI) 08/01/2011 - 07/31/2016 NIH/NIAMS Translation of Quantitative Imaging in Osteoarthritis The overall objective of this proposal is to integrate cutting edge, quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. Role:Clinical Director Co-Project Leader Majumdar Rodeo (PI) 09/01/2013 - 08/31/2015 Arthritis Foundation A Multi-center Feasibility Trial establishing Imaging and Biochemical Technologies as Measures of Knee Cartilage Composition Following Acute ACL Injury A multi-center study to look at quantitative MRI on cartilage degeneration following ACL injury Role:Site Leader Ma (PI) 03/15/2012 - 02/28/2015 Histogenics, Inc. Neocart versus microfracture Phase III: Randomized clinical trial on two cartilage resurfacing procedures Role:PI Ma (PI) 12/2012 - 12/01/2022 Moximed Phase I clinical IDE trial for the KineSpring Knee Implant, an investigational device intended to treat pain and loss of function caused by medial compartment knee osteoarthritis Role:P.I. 05/01/2011 - 04/30/2024 Zimmer, Inc. Zimmer Prospective Post Market Clinical Follow-Up Study of the Zimmer® Trabecular Metal™ Reverse Shoulder System Role:PI P50AR060752 Majumdar/Lane (PI) 07/01/2011 - 03/31/2016 NIH/NIAMS Translation of Quantitative Imaging in Osteoarthritis This CORT grant investigates the possibility of quantitative imaging on evaluating the progression of osteoarthritis. In this study, we have one out of the four project on the evaluation of cartilage degeneration following ACL tear and reconstruction. This study utilizes T1rho imaging, kinematic MRI and function evaluation of ACL injured patients. Role:Co Project Leader, Clinical Director AOSSM/Genzyme Osteoarthritis Grant for Clinical Research Ma (PI) 01/01/2012 - 12/31/2014 AOSSM ACLinjury, gender and cartilage degeneration This grant explores the effect of gender on outcome following ACL reconstructive surgeries Role:PI Completed Research Support 2001 - 2002 Orthopaedic Research and Education Foundation Cine Magnetic Resonance Imaging of the ACL-deficient and reconstructed knees Role:PI 08/01/2004 - 08/01/2004 University of California, San Francisco REAC grant Kinematic Magnetic Resonance Imaging of Cruciate Ligament Injured Knees Role:PI Young Investigator Grant 08/01/2004 - 08/01/2004 AOSSM Kinematic Magnetic Resonance Imaging of the Anterior Cruciate Ligament Injured and Reconstructed Knee Role:PI 08/01/2005 - 08/01/2008 Orthopaedic Research Education Foundation Grant Dynamic Magnetic Resonance Imaging of the Knee - the Effect of Ligament Injury and Reconstruction" Role:PI Aircast Foundation Research Grant 08/01/2005 - 08/01/2005 Assessment of Cartilage and Subchondral Bone Injuries of the Knee Following ACL Tear with High Field Magnetic Resonance Imaging Role:Co-investigator, 20% effort AOSSM Cartilage Workshop Grant 01/01/2007 - AOSSM Evaluation of the Treatment of Articular Cartilage Injuries using Quantitative MR Imaging Role:PI OREF/ASES/Rockwood Clinical Shoulder 05/01/2011 - 04/30/2012 American Orthopaedic Society for Sports Medicine (OREF) Impact of Postoperative Management on Patient Outcomes and Healing of Rotator Cuff Repairs Role:Co-Investigator 01/01/2011 - 12/31/2012 Arthrex Inc. Impact of Postoperative Management on Patient Outcomes and Healing of Rotator Cuff Repairs Role:Co-Investigator 05/01/2009 - 12/31/2013 Wyeth A Prospective Study to Evaluate Surgical Outcomes in Subjects with Full-Thickness Rotator Cuff Tears Treated by Means of a Double-Row Arthroscopic Role:PI RO1 AG017762 09/15/2007 - 06/30/2012 NIH Bioengineering Research Partnership: Morphological and Functional Imaging of the Musculoskeletal System Role:Co-investigator, 5% effort 08/15/2007 - 08/14/2012 Histogenics, Inc. Neocart versus microfracture Phase II clinical tria: Randomized clinical trial on two cartilage resurfacing procedures Role:PI RO1 AR46905-01 08/01/2006 - 08/01/2010 NIH Cartilage Bone Interactions in Osteoarthritis Role:Co-investigator, 5% effort

BIOGRAPHICAL SKETCH NAME POSITION TITLE Majumdar, Sharmila Professor and Vice Chair, Radiology eRA COMMONS USER NAME (credential, e.g., agency login) Director, MQIR SMAJUMDAR EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) St. Stephens College, University of Delhi, India B.S. 1983 Physics Yale University, Connecticut, USA M.S. 1984 Eng. & Applied Physics Yale University, Connecticut, USA Ph.D. 1987 Eng. & Applied Physics Yale University, Connecticut, USA Postdoctoral 1988 Radiology A. Personal Statement I have worked in the area of Musculo-skeletal Imaging for the past 20 years. My research specifically uses and develops imaging technology such as MRI, µCT, HRpQCt to quantify cartilage morphology, biochemistry, trabecular bone density and structure, to quantify the structure of the invertebral disk and to analyze the complex kinematics of the knee. These projects require 3D image processing, and computation of kinematic models, all of which require high level computational resources. I serve as the Vice Chair of Research and Professor in the Department of Radiology and Biomedical Imaging, and the director of the Musculoskeletal Quantitative Imaging Research group (MQIR); the resources from this proposal will be a benefit to the research programs not just of MQIR but for many of the departmental projects. As such, I am in full support on the proposed PhD program in Rehabiliation Science and look forward to continuing interactions with the faculty and students in the Department of Physical Therapy and Rehabiliation Science.

B. Positions and Honors Positions and Employment 2001–present Professor, Dept. of Radiology, University of California, San Francisco, CA 2002–2009 Member, Division of Bioengineering, University of California San Francisco, CA 2002–present Professor, Dept. of Bioengineering, University of California, Berkeley, CA 2003–present Director, Musculo-skeletal and Quantitative Imaging Research Group, Dept. of Radiology, University of California, San Francisco, CA 2003–present Member, California Institute for Quantitative Biomedical Research (QB3) 2008–present Vice Chair, Dept. of Radiology, University of California, San Francisco, CA 2009–present Joint Faculty Member, Dept. of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA Honors 2002 Celebrating Woman Faculty, Award and Recognition, Chancellor and Deans of UCSF 2004 Fellow of the American Institute of Medical and Biological Engineers (AIMBE) 2008 Fellow of the International Society of Magnetic Resonance in Medicine (ISMRM)

C. Selected Peer-reviewed Publications (Selected from 327) 1. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution Dependence of the Non-metric Trabecular Structure Indices. Bone. Apr/2008;42(4):728-736. PMCID: PMC2329672 2. Carballido-Gamio J, Joseph GB, Lynch JA, Link TM, Majumdar S. Longitudinal analysis of MRI T(2) knee cartilage laminar organization in a subset of patients from the osteoarthritis initative. Magn Reson Med. 2010 Feb;63(2):465-72. PMID: 19918905 3. Folkesson J, Carballido-Gamio J, Eckstein F, Link TM, Majumdar S. Local bone enhancement fuzzy clustering for segmentation of MR trabecular bone images. Med Phys. 2010 Jan;37(1):295-302. PMCID: PMC2804381 4. Carballido-Gamio J, Majumdar S. Atlas-based knee cartilage assessment. Magn Reson Med. 2011 Aug;66(2):574-83. PMCID: PMC3346276 5. Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S. Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior

cruciate ligament transection model of osteoarthritis. Magn Reson Imaging. 2012 Feb;30(2):271-82. PMCID: PMC3307548 6. Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr;39(4):1893-903. PMCID: PMC3316694 7. Joseph GB, Baum T, Alizai H, Carballido-Gamio J, Nardo L, Virayavanich W, Lynch JA, Nevitt MC, McCulloch CE, Majumdar S, Link TM. Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years—data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2012 Jul;20(7):727-35. PMCID: PMC3595156 8. Alizai H, Nardo L, Karampinos DC, Joseph GB, Yap SP, Baum T, Krug R, Majumdar S, Link TM. Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women. Eur Radiol. 2012 Jul;22(7):1592-600. PMCID: PMC3584153 9. Stehling C, Souza RB, Hellio Le Graverand MP, Wyman BT, Li X, Majumdar S, Link TM. Loading of the knee during 3.0T MRI is associated with significantly increased medial meniscus extrusion in mild and moderate osteoarthritis. Eur J Radiol. 2012 Aug;81(8):1839-45. PMCID: PMC3399044 10. Kumar D, Schooler J, Zuo J, McCulloch CE, Nardo L, Link TM, Li X, Majumdar S. Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn meidal meniscal tears. Osteoarthritis Cartilage. 2013 Jan;21(1):86-93. PMCID: PMC3538917 11. Kazakia GJ, Kuo D, Schooler J, Siddiqui S, Shanbhag S, Bernstein G, Horvai A, Majumdar S, Ries M, Li X. Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthritis Cartilage. 2013 Jan,21(1):94-101. PMCID: PMC3538951 12. Jobke B, Bolbos R, Saadat E, Cheng J, Li X, Majumdar S. Mechanism of disease in early osteoarthritis: application of modern MR imaging techniques – a technical report. Magn Reson Imaging. 2013 Jan;31(1):156-61. PMCID: PMC3504629 13. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt A, Majumdar S. Age-and gender-related differences in cortical geometry and microcstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb;52(2):623-31. PMCID: PMC3564644 14. Souza RB, Feeley BT, Zarins ZA, Link TM, Li X, Majumdar S. T1rho MRI relaxation in knee OA subjects with varying sizes of cartilage lesions. Knee. 2013 Mar;20(2):113-9. PMCID: PMC356898 15. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke JK, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multi-center precision of cortical and trabecular bone quality measures assessed by HR- PQCT. J Bone Miner Res. 2013 Mar;28(3):524-36. PMCID: PMC3577969

D. Research Support Ongoing Research Support ACL Feasibility Trial (Majumdar) 08/01/2013-06/30/2015 NIH/NIA A multicenter feasibility trial establishing imaging and biochemical technologies as measures of knee cartilage composition following acute ACL injury The aim of this project is to establish precise, accurate quantitative measures of T1p and T2 of articular cartilage and meniscus, and to validate morphological characteristics of the joint using 3 Tesla MR imaging, both in phantoms and control subjects, across three nationally recognized sports medicine centers.

P50AR060752 (Majumdar/Lane MPI) 08/01/2011-07/31/2016 NIH/NIAMS Translation of Quantitative Imaging in Osteoarthritis The overall objective of this proposal is to integrate cutting edge, quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. Role: PI

R01AR046905-11A1 (Majumdar) 06/20/2011- 05/31/2016 NIH/NIAMS Loaded and Unloaded MR Imaging of Meniscus-Cartilage-Trabecular Bone in OA

This study will develop non invasive biomarkers for cartilage and meniscus degeneration in the knee.We will also examine differences in these tissues with loading. This will help individuals who have or are at risk for developing osteo-arthritis. Role: PI

R01 AR060700-01 (Lang/Burghardt) 09/01/2011-07/31/2015 NIH Bone quality by vQCT and HR-pQCT: translation to multi-center clinical research The major goal of this project is to develop cross-calibration techniques for bone strength and structure assessments from vQCT and HR-pQCT and to make publically available the analytic software developed by Lang’s group at UCSF. Role: Co-Investigator

MERCK & CO Contract (Majumdar) 06/01/2013-05/31/2014 Non-invasive Assessment of Bone Micro-architecture and Strength Changes in Androgen Deprivation Therapy. The goal of this project is to study regional changes in trabecular bone, as well as changes in cortical porosity in the context of male osteoporosis, and determine how they affect bone strength and other precursors to other therapeutic trials.

Bell Biosystems Contract (Majumdar) 06/01/2013-05/31/2014 The goal of this project is to determine the longevity of Magnelles in phantom models and performing ex vivo imaging with post-mortem mice to establish optimal anatomical sites for Magnelles labeled cell implantation and imaging.

GE Contract Exhibit A-77 (Majumdar) 11/01/2012-10/31/2013 GE Healthcare Improved Quantitative and Real Time MR imaging The goal of this project is to develop new technology for clinical use that tracks real-time changes in tissue metabolism while focusing on developing new magnetic resonance (MR) imaging and spectroscopy techniques that are expected to enable earlier diagnosis and treatment of cancer and other diseases tailored to individual patients. The ultimate goal here is to redefine the detection, diagnosis and treatment timeline of diseases such as prostate cancer. This is a holistic and patient-focused approach where UCSF is providing computational and clinical expertise.

Completed Research Support R01 AR057336-01 Krug (PI) 09/01/09 – 08/31/13 In-Vivo Assessment of Trabecular Microstructure at the Proximal Femur The objective of this project is to conduct unprecedented high-resolution imaging of the human musculoskeletal system through the use and development of multichannel coils and novel acquisition techniques. Role: Co-Investigator

U01AR059507 Link (PI) 07/01/10-06/30/13 NIAMS/NIH T2 Relaxation Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort The aim of this project is to study whether T2 relaxation time measurements of the cartilage can be used as a sensitive measure to predict degeneration of the knee joint in individuals from the osteoarthritis incidence cohort with different levels of physical activity. Role: Co-Investigator

5 R01 AR05449602 Recker (PI) 04/01/08 – 03/31/13 A Study of Reduced Bone Quality As A Cause of Fractures The purpose of this human study is to use biopsy and imaging assessments to characterize defects in bone quality, independent of bone mass, that contribute to low trauma fractures in postmenopausal women. Role: Co-Investigator

RC1 AR058405 Link (PI) 09/30/09 – 08/31/12 NCE Cortical Bone Porosity Identifies Diabetes Subjects with Fragility Fractures

The major goal of this grant is to study cortical and trabecular bone architecture in diabetes subjects with and without osteoporotic fractures and to compare these findings to those in normal subjects and osteoporotic fracture subjects. Role: Co-Investigator

F32 AR059478 Blumenkrantz (PI) 04/01/10 – 06/30/12 MRI T2 Relaxation Time as a Predictor of Osteoarthritis The ultimate goal of this project is to assess the relationship between cartilage biochemical composition, as quantified by novel MRI techniques (specifically T2 mapping), and longitudinal changes in cartilage morphology. Role: Sponsor

R01 AG017762 Majumdar (PI) 09/15/2007 – 06/30/2012 NIH/NIA Bioengineering Research Partnership: Morphological And Functional Musculo-Skeletal Imaging In this grant, participants from the University of California, San Francisco (UCSF), University of California, Berkeley (UCB), and industry (General Electric) have renewed a Bioengineering Research Partnership (BRP) focused on the systematic study of the morphology and function of the musculoskeletal system in disease and health. We hypothesize that high field (3 Tesla and 7 Tesla), high resolution, fast MR combined with quantitative tissue assessment would significantly impact the clinical assessment of musculoskeletal degeneration and reparative processes, spanning a range of scales, from the tissue to the whole organ. The long-term vision of this partnership is to understand the link between morphology, function and clinical symptoms, with a specific focus on osteoporosis, osteoarthritis, and degenerative disc disease. Role: PI

Nelson/Vigneron (Co-PIs) 06/01/10 – 05/31/12 UC Discovery Research & Training Grant (DRT) Novel MR Technology for Monitoring Treatment Effects in Human Disease The objective is to advance cutting edge non-invasive Magnetic Resonance (MR) imaging technologies that are being developed as part of a collaborative partnership between researchers at UCSF and GEH, to use improved hardware and software capabilities to define the improvements in diagnostic and therapy monitoring capabilities of two key technologies: (1) use of new 7T whole body scanner technology to more clearly visualize small vascular structures, increased iron deposition associated with degeneration of neuronal structures, radiation damage, abnormal metabolism and changes in cartilage thickness. (2) use of hyperpolarized C-13 metabolic imaging, to provide a very rapid readout of changes in biochemical properties associated with abnormal tissue structure and function. Role: Co-Investigator

R01AG029571-01A2 (Lang) 09/01/2008 - 05/31/2012 NIH/NIA The Proximal Femoral Musculature: A New Risk Factor for Hip Fracture Understand the role of muscle parameters characterized by CT as predictors of hip fracture and to develop new approaches to quantifying muscle size and density of the hip musculature from CT scans of the hip Role: Co-Investigator

R01 AR046905-09 Majumdar (PI) 04/19/06 – 01/31/12 Cartilage-Bone Interactions In Osteoarthritis This grant focuses on using magnetic resonance (MR) imaging at 3 Tesla to study joint degeneration and the manifested changes in articular cartilage, subchondral bone, peri-articular trabecular bone and bone marrow. Role: PI

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Maze, Mervyn Professor and Chair, Department of Anesthesia and eRA COMMONS USER NAME (credential, e.g., agency login) Perioperative Care, UCSF Mervyn EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Cape Town, South Africa MB ChB 1965-1970 Medicine Groote Schuur Hospital, Cape Town, South Africa 1972 Internship Royal Free Hospital, London Registrar 1973-1976 Medicine Stanford University Postdoc 1976-1979 Medicine Stanford University Resident 1979-1981 Anesthesia

A. Personal Statement I am an experienced investigator with more than 250 peer-reviewed publications describing my original research that has also spawned the filing of 9 patents, the establishment of one company, the clinical use of two new compounds and the virtual abandonment of another. My recent research is focused on neuroinflammation, macrophage polarization and inflammation resolving mechanisms. My laboratory was the first to uncover a link between peripheral surgery and neuroinflammation. Using probes that disrupt the inflammatory cascade, such as anti-TNF antibody, clodrolip (depletion of peripheral macrophages), and genetically-modified reagents, we have established a causal relationship between surgery-induced neuroinflammation and short-lived cognitive decline. We have identified a role for resolving mechanisms to dampen the postoperative neuroinflammatory response and curtail the cognitive decline that follows and have demonstrated the consequences of disabling the cholinergic anti- inflammatory pathway in the setting of the aseptic trauma of surgery. We are now studying the influence of pre—operative exercise training on the inflammatory response to surgery in reagents with dysregulated inflammation resolving mechanism in the setting of the Metabolic Syndrome. Regarding postgraduate training, I have supervised 10 PhD students and 22 postdoctoral fellows.

B. Positions and Honors Positions and Employment 1981-1987 Assistant Professor, Department of Anesthesia, Stanford University 1981-1999 Staff Physician, Veterans Affairs, Palo Alto Health Care System 1987-1999 Neuroscience Graduate Program, Stanford University 1995-1997 Director of Research, Department of Anesthesia, Stanford University 1988-1994 Associate Professor, Department of Anesthesia, Stanford University 1994-1999 Professor, Department of Anesthesia, Stanford University 1995-1997 Director of Research, Department of Anesthesia, Stanford University 1997-1999 Associate Chair for Research, Department of Anesthesia, Stanford University 1999-Present Sir Ivan Magill Professor of Anaesthetics, Imperial College 2000-Present Head, Department of Anaesthetics and Intensive Care, Imperial College 2000-2007 Deputy Head, Division of Surgery, Anaesthetics and Intensive Care, Imperial College 2001-2008 Director, Research and Development, Chelsea and Westminster Hospital, London, UK 2002-2006 Director, Multi-Disciplinary Education Training and Research, Chelsea and Westminster Hospital, London, UK 2002-2009 Campus Dean for the Chelsea and Westminster Hospital Site, Imperial College, London 2007-2009 Head of Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College, London 2009-Present Chair, Department of Anesthesia and Perioperative Care, UCSF

Other Experience and Professional Memberships Certifications 1973 (March) Member of the Royal College of Physicians, UK, (M.R.C.P.) 1982 (April) Certified by the American Board of Anesthesiology University and Hospital 1981-1990 Resident’s Education Committee, Stanford University 1982-1999 Well-Being of Physicians, Stanford Health Services 1985-1995 Animal Care & Use Committee, Veterans Affairs Hospital 1987-1999 Appointment and Promotions Committee, Stanford University 1988-1992 Minority Admissions Advisory Panel, Stanford University 1992-1999 Medical School Admission Committee, Stanford University 1992-1999 South African Faculty Initiative Committee, Stanford University 1995-1999 Research Committee, Stanford University 1996-1999 Laboratory Safety Committee, Stanford University 2001-2009 Chair, Finance Committee, Faculty of Medicine, Imperial College 2001-2009 HR Committee, Faculty of Medicine, Imperial College 2001-2009 NHS-Imperial College Liaison Group 2002-2009 Principal’s Advisory Group, Imperial College 2009-Present UCSF SOM Finance Committee 2009-Present UCSF Space Committee 2009-Present Faculty Oversight Committee on Operational Excellence 2011-Present Long Range Development Plan Clinical Facilities Planning Subcommittee

National 1988-1992 Scientific Advisory Board, Association of University Anesthesiologists 1988-1992 Associate Editor, Anesthesiology 1995-1998 Councilor, Association of University Anesthesiologists 1995-1999 Associate Editor, Anesthesiology 1999-2008 Editor, Anesthesiology 2008-2009 Chair, Specialty of Anaesthesia, UK CRN

Honors 1995 Fellow of Royal College of Physicians 1999 Fellow of Royal College of Anaesthetists 2002 Fellow of Academy of Medical Sciences 2003 Excellence in Research Award from the American Society of Anesthesiologists. 2009 FAER Plenary Lecturer 2010 AUA Plenary Lecturer

C. Selected peer-reviewed publications (selected from 259 articles, 30 chapters, 3 books) 1. Vacas S, Degos V, Feng X, Maze M: The neuroinflammatory response of postoperative cognitive decline. Br Med Bull. 2013;106:161-78. 2. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M: Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013;118(3):527-36. 3. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H: Bone Fracture Exacerbates Murine Ischemic Cerebral Injury. Anesthesiology. 2013 Jun;118:1362-72. 4. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M: Surgery Results in Exaggerated and Persistent Cognitive Decline in a Rat Model of the Metabolic Syndrome. Anesthesiology. 2013 May;118:1098-105. 5. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M: Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 8;18:1481-90. PMC3576477

6. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D: Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. PLoS One. 2011;6(11). PMC3207823 7. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M: Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec;70(6):986-95. doi: 10.1002/ana.22664. 8. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M: Anticipating and managing postoperative delirium and cognitive decline in adults. BMJ. 2011 Jul 20;343:d4331. 9. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D: Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci Lett. 2011 Jul 1;498(1):63-6. 10. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG: Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Anesthesiology. 2011 Apr;114(4):891-900. PMC3063324 11. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M: Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20518-22. PMC2996666 12. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D: Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Crit Care Med. 2010 Nov;38(11):2190-8. 13. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS,Maze M: Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol.2010Sep;68(3):360-8. 14. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007 Mar;106(3):436-43. 15. Newman S, Sytgall J, Hirani S, Shaefi S, Maze M. Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology. 2007 Mar; 106(3):572-90

D. Research Support Ongoing Research Support 1R01 GM104194-01A1 Maze (PI) 09/01/13-08/31/17 Inflammation resolving mechanism dysregulation in postoperative cognitive decline Purpose: To test the hypothesis that the abnormalities in inflammation-resolution are the cause for the exaggerated and persistent postoperative cognitive decline in this rat model of the Metabolic Syndrome. Role: PI

Medical Research Council Experimental Medicine (PI) 2009-2013 Neuroprotective effects of hypothermia combined with inhaled xenon and inhaled Xenon following perinatal asphyxia Role: Investigator

5R01 HL111111-02 Pandharipande (PI) 08/15/12-06/30/17 Altering sedation paradigms to improve brain injury and survival in severe sepsis Purpose: To maximize the efficacy of sedation and reduce neurological dysfunction and mortality in septic patients with acute respiratory failure. Role: Co-Investigator

Completed Research Support MRC Clinical Scientist Training Fellowship Award (PI) 2009-2011 Dexmedetomidine or Midazolam sedation and immune function in the inflamed lung Role: Co-Principal Investigator

Program Director/Principal Investigator: McQuillen

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE McQuillen, Patrick Sean Associate Professor In Residence eRA COMMONS USER NAME (credential, e.g., agency login) MCQUILLEN

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Stanford University, Palo Alto, CA B.S. 06/86 Biology University of California, San Diego M.D. 06/91 HHMI NIH National Cancer Institute Research 06/91 Immunology Scholar University of California, San Francisco Resident 06/94 Pediatrics Clinical University of California, San Francisco 06/97 Pediatric Critical Care Fellow University of California, Berkeley Postdoctoral Developmental 06/99 Supervisor: Dr. Carla Shatz Fellow Neuroscience

A. Personal Statement As a pediatric critical care clinical specialist and neuroscientist, my research program focuses on the effects of early brain injury on brain development and plasticity. In addition to a basic laboratory research program, I direct a multicenter clinical research program using advanced magnetic resonance imaging in fetuses and newborns with congenital heart disease. These research programs are fully supported by NIH grants (R01 & P01) and have involved high school students, undergraduates, medical and graduate students, pediatrics residents, clinical and postdoctoral fellows. I serve on departmental, medical school and university Academic Senate committees focused on fostering student research and fellow/faculty development. I am a member of the UCSF Biomedical Sciences and Graduate Education in Medical Sciences Training Programs, serving on thesis committees (3) and teaching (Group leader, Tissue and Organ Biology). I participate in the research training of Pediatric clinical fellows by serving as faculty for three T32 and one K12 training programs. I was a founding member of the Department of Pediatrics Professional Development Committee that created the Fellow’s College and Scholarship Oversight Committees to advise and supervise research by clinical fellows. Within my clinical division, I organize a monthly joint research conference for the divisions Pediatric Critical Care and Neonatology programs. In my own lab, I have directly supervised four undergraduate, six post- graduate, one medical student and two junior faculty over the last four years. These individuals have successfully applied for AHA (2), UCSF Dean's Office research internships and a Doris Duke Foundation Clinical Research Scholarship. The research has led to ten first author publications by mentees. Four undergraduates mentored have successfully applied for medical school admission. Three have been admitted to graduate studies in neuroscience. Three clinical fellows have obtained academic faculty positions and one has been admitted to fellowship training in neonatology. I look forward to participating as a research mentor in this new Department of Physical Therapy and Rehabilitation Science Ph.D. program in Rehabilitation Science. I am committed to creating an atmosphere that welcomes and inspires trainees to become enthusiastic about science and medicine. B. Positions and Honors Principals Positions Held 2008 present University of California San Associate Professor Pediatrics Francisco in Residence

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: McQuillen

Other Positions Held Concurrently 2008 present University of California San Faculty Francisco, Graduate Research Training in Perinatal Biology (T32, Rowitch PI) 2008 present University of California San Faculty Francisco, Research Training in Pediatric Critical Care Medicine (T32, Fineman PI) 2008 present University of California San Faculty Francisco, Training in Developmental Cardiovascular Biology (T32, Srivastava PI) 2008 present University of California San Faculty Francisco, Neurological Scientist Academic Development Program (K12, Fullerton PI) 2009 present University of California San Faculty Advisor Francisco, Graduate Education in Medical Sciences (GEMS) Training Program 2009 present University of California San Faculty Neuroscience Francisco, Graduate Program in Biomedical Sciences (BMS) 2010 present University of California San Faculty Francisco, School of Medicine Pathways to Discovery in Molecular Medicine 2010 present University of California San Associate Professor Neurology Francisco in Residence

Honors Awards 1990 Howard Hughes Medical Institute Research Scholarship 1995 Pediatric Scientist Development Award 2000 NIH, NICHD Mentored Clinical Scientist Award 2004 NIH, NINDS Independent Scientist Award 2005 Society of Pediatric Research 2006 Outstanding Investigator Children's Hospital of Philadelphia, Cardiology. 2011 American Pediatric Society

Memberships

Service to Professional Organizations C. Selected Peer-Reviewed Publications 1. DeFreitas MF, McQuillen PS, Shatz CJ. A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons. J Neurosci. 2001 Jul 15; 21(14):5121-9. PMID: 11438587 2. McQuillen PS, DeFreitas MF, Zada G, Shatz CJ. A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation. J Neurosci. 2002 May 1; 22(9):3580-93. PMID: 11978834 3. McQuillen PS, Sheldon RA, Shatz CJ, Ferriero DM. Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia. J Neurosci. 2003 Apr 15; 23(8):3308-15. PMID: 12716938 4. Chang YS, Mu D, Wendland M, Sheldon RA, Vexler ZS, McQuillen PS, Ferriero DM. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res. 2005 Jul; 58(1):106-11. PMID:

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: McQuillen

15879287 5. Gonzalez FF, McQuillen P, Mu D, Chang Y, Wendland M, Vexler Z, Ferriero DM. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci. 2007; 29(4-5):321-30. 17762200 6. Miller SP, McQuillen PS, Hamrick S, Xu D, Glidden DV, Charlton N, Karl T, Azakie A, Ferriero DM, Barkovich AJ, Vigneron DB. Abnormal brain development in newborns with congenital heart disease. N Engl J Med. 2007 Nov 8; 357(19):1928-38. PMID: 17989385 7. Nguyen V, McQuillen PS. AMPA and metabotropic excitoxicity explain subplate neuron vulnerability. Neurobiol Dis. 2010 Jan; 37(1):195-207. PMID: 19822212 PMCID: PMC2789448 8. Failor S, Nguyen V, Darcy DP, Cang J, Wendland MF, Stryker MP, McQuillen PS. Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex. J Neurosci. 2010 Jan 6; 30(1):81-92. PMID: 20053890 PMCID: PMC2822440 9. Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. Dev Neurosci. 2010 Jul; 32(2):101-13. PMID: 20453463 10. Block AJ, McQuillen PS, Chau V, Glass H, Poskitt KJ, Barkovich AJ, Esch M, Soulikias W, Azakie A, Campbell A, Miller SP. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2010 Sep; 140(3):550-7. PMID: 20434174 PMCID: PMC2917479 11. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter- Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. Harnessing neuroplasticity for clinical applications. Brain. 2011 Jun; 134(Pt 6):1591-609. PMID: 21482550 PMCID: PMC3102236 12. Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Towards the "baby connectome": mapping the structural connectivity of the newborn brain. PLoS One. 2012;7(2):e31029. Epub 2012 Feb 7. PMID:22347423 PMCID: PMC3274551 13. Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM. Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. Stroke. 2013 Mar; 44(3):753-8. PMID: 23391775 14. Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS. Single ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 Feb 13. PMID: 23407116 15. Dimitropoulos A, McQuillen PS, Sethi V, Moosa A, Chau V, Xu D, Brant R, Azakie A, Campbell A, Barkovich AJ, Poskitt KJ, Miller SP. Brain injury and development in newborns with critical congenital heart disease. Neurology. 2013 Jul 16; 81(3):241-248. PMID: 23771484 D. Research Support On-going Research Support 2R01 NS060896 06/01/2013 - 05/31/2018 NIH NINDS - Impact score 23, Percentile 10% Critical Period Plasticity Following Neonatal Brain Injury. These are studies of activity dependent brain development and repair following early hypoxia ischemia in a rodent model. Role:PI 1 P01 NS082330 09/01/2013 - 08/31/2018 NIH NINDS - Impact score 17, Project 2 Impact score - 12 Repair after neonatal brain injury (Ferriero). Project 2: Repair in high risk newborns with congenital heart disease. These are clinical studies of brain development, injury and repair in high risk newborns with critical congenital heart disease. Role:Project 2 PI

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator: McQuillen

#6-FY2009-303 Miller (PI) 10/01/2009 - 05/30/2015 March of Dimes Birth Defects Foundation Practice Variation Contributes to Brain Injury in Newborns with Congenital Heart Disease. This project investigates the contribution of clinical practice pattern differences across two centers and how these differences are associated with perioperative brain injury on MRI. Role:Site-PI U01HL09434511A1 Moler (PI) 07/01/2011 - 06/30/2016 NIH NIHLB NICHD Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trials This is a multicenter clinical trial to determine if moderate hypothermia improves one year outcome in children following cardiac arrest. Role:Site-PI Completed Research Support 2 P50 NS035902-11A1 Ferriero (PI) 09/01/2007 - 01/31/2014 NIH NINDS Mechanisms of Ischemic Neonatal Brain Injury The goal of this project is investigate the role of ischemia in the generation of neonatal brain injury. The current projects include Project 1, White matter injury as predictor of outcome in neonatal brain injury (A. James Barkovich, PI), Project 2, The role of VEGF in recovery after ischemic neonatal brain injury (Donna Ferriero, PI), Project 3, Effect of polyphenols on neonatal HI brain injury (David Holtzman, PI). There are two cores: administration Core A and imaging (Scientific, Zena Vexler, PI) Core B. Role:Project 2 Co-I 5R01NS060896-02 McQuillen (PI) 04/01/2008 - 03/30/2013 NIH NINDS Critical Period Plasticity Following Early Brain Injury. The overall goal of this grant is to understand the basic mechanisms behind impaired structural plasticity following early brain injury in a rodent model. Ocular dominance plasticity in the visual system serves as a novel outcome measure and a model for the functional regeneration of neuronal connections following injury. Role:PI 1R01NS063876-01A2 McQuillen (PI) 09/30/2009 - 08/31/2012 NIH NINDS White Matter Injury in Critically Ill Newborns With Congenital Heart Disease. The goal of this study is to use perioperative advanced MR imaging in fetuses and neonates with congenital heart disease to determine if fetal and postnatal delayed brain development is a risk factor for perioperative white matter injury. Role:PI 6-FY2008 McQuillen (PI) 05/01/2008 - 04/28/2011 March of Dimes Birth Defects Foundation Role of gap-junction coupling in impaired cortical plasticity following neonatal brain injury. This project investigates the specific role of gap-junction mediated subplate neuron excitotoxicity as a mechanism of selective subplate neuron vulnerability involved in impaired cortical plasticity following neonatal brain injury. Role:PI 1 K02 NS047098-01A1 McQuillen (PI) 09/01/2004 - 08/31/2009 NIH NINDS Selective Subplate Vulnerability and Cortical Plasticity. The goal of this investigation is to understand the relationship between hypoxic-ischemic subplate neuron death and cortical plasticity, both anatomical and physiologic. Role:PI

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Miaskowski, Christine A. Professor eRA COMMONS USER NAME Miaskowski EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Molloy College, Rockville Center, NY BSN 1974 Nursing Adelphi University, Garden City, NY MS 1979 Nursing St. John’s University, Jamaica, NY MS 1984 Biology St. John’s University, Jamaica, NY PhD 1987 Physiology University of California, San Francisco, CA Post-doc 1988-90 Pain management

A. Personal Statement

Dr. Miaskowski is highly qualified to serve as a mentor for the doctoral program in physical therapy because of her previous experience mentoring predoctoral students, postdoctoral fellows, and junior faculty members across a variety of health care disciplines. Dr. Miaskowski’s program of research focuses on the identification of phenotypic and genotypic markers that place patients at highest risk for the development of the most deleterious symptoms that occur as a result of cancer and its treatment. Currently, she has three federally funded R01 grants that span the spectrum of descriptive correlational research to randomized clinical trials of pharmacologic and behavioral interventions to decrease cancer pain.

During the past 22 years, Dr. Miaskowski has served as the dissertation chair for 24 doctoral students, served on an additional 29 dissertation committees, has mentored 10 postdoctoral fellows, and served as the primary mentor for 16 junior faculty members. In her role as Department Chair from 1994 to 2004, Dr. Miaskowski mentored 20 faculty members to receive NIH funding. Dr. Miaskowski has published 207 peer reviewed papers with her trainees and has facilitated their obtaining extramural funding and faculty positions. In 2008, she received the Teaching Award for Excellence in Research Mentoring. She will provide trainees with research space, methodological and statistical training with members of her research team, and access to data from five federally funded R01 studies.

B. Positions and Honors

Positions and Employment 1979-81 Staff Development Instructor, Hospital of Albert Einstein College of Medicine, Bronx, NY 1981-85 Clinical Nurse Specialist in Oncology and Critical Care and Nurse Coordinator of the Pain Evaluation Group, Hospital of Albert Einstein College of Medicine, Bronx, NY 1985-88 Assistant Professor and Coordinator of the Oncology Master’s Program, School of Nursing, Department of Continuing Education, Adelphi University, Garden City, NY 1986-88 Coordinator of Clinical Practice and Quality Assurance, Hospital of Albert Einstein College of Medicine, Bronx, NY 1988-90 Robert Wood Johnson Clinical Nurse Scholar, Department of Physiological Nursing, University of California, San Francisco, CA 1990-96 Associate Professor, Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA 1996-now Professor, Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA

Program Director/Principal Investigator (Last, First, Middle): Other Experiences and Professional Memberships 1996-2000 Councilor (elected), International Association for the Study of Pain 2002-03 President, American Pain Society 2002-now Co-Program Leader in Symptom Management, Palliative Care, and Survivorship, UCSF Comprehensive Cancer Center 2005 Chair of the Nursing Study Section, Center for Scientific Review, National Institutes of Health Honors 2000 Distinguished Nurse Researcher, Oncology Nursing Society 2000 Helen Nahm Research Lecturer, School of Nursing, University of California, San Francisco 2000 Wilbert Fordyce Clinical Investigator Award, American Pain Society 2002 Distinguished Merit Award from the International Society of Nurses in Cancer Care 2005 Distinguished Service Award, American Pain Society 2006 Distinguished Researcher Award, Western Institute of Nursing Research 2008 Sharon A. Lamb Endowed Chair in Symptom Management Research 2010 American Cancer Society Clinical Research Professorship

C. Selected peer-reviewed publications (in chronological order). (Selected from 400 peer-reviewed publications)

1. Stephens K, Cooper BA, West C, Paul SM, Baggott CR, Merriman JD, Dhruva A, Kober KM, Langford DJ, Leutwyler H, Luce JA, Schmidt BL, Abrams GM, Elboim C, Hamolsky D, Levine JD, Miaskowski C, Aouizerat BE. Associations Between Cytokine Gene Variations and Severe Persistent Breast Pain in Women Following Breast Cancer Surgery. J Pain. 2013 Oct 12. Epub ahead of print. 2. Ritchie C, Dunn LB, Paul SM, Cooper BA, Skerman H, Merriman JD, Aouizerat B, Alexander K, Yates P, Cataldo J, Miaskowski C. Differences in the Symptom Experience of Older Oncology Outpatients. J Pain Symptom Manage. 2013 Jul 31. Epub ahead print. PMCID: PMC3833968. 3. Langford DJ, West C, Elboim C, Cooper BA, Abrams G, Paul SM, Schmidt BL, Levine JD, Merriman JD, Dhruva A, Neuhaus J, Leutwyler H, Baggott C, Sullivan CW, Aouizerat BE, Miaskowski C. Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery. J Neurogenet. 2014 Jan 7. Epub ahead of print. 4. Jeevanjee S, Penko J, Guzman D, Miaskowski C, Bangsberg DR, Kushel MB. Opioid Analgesic Misuse is Associated with Incomplete Antiretroviral Adherence in a Cohort of HIV-Infected Indigent Adults in San Francisco. AIDS Behav. 2013 Sep 28. Epub ahead of print. 5. Rustøen T, Valeberg BT, Kolstad E, Wist E, Paul S, Miaskowski C. A Randomized Clinical Trial of the Efficacy of a Self-care Intervention to Improve Cancer Pain Management. Cancer Nurs. 2014;37(1):34-43. 6. Vijayaraghavan M, Penko J, Bangsberg DR, Miaskowski C, Kushel MB. Opioid analgesic misuse in a community-based cohort of HIV-infected indigent adults. JAMA Intern Med. 2013;11;173(3):235-7. 7. Cataldo JK, Paul S, Cooper B, Skerman H, Alexander K, Aouizerat B, Blackman V, Merriman J, Dunn L, Ritchie C, Yates P, Miaskowski C. Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study. BMC Cancer. 2013;13:6. PMCID: PMC3576303. 8. Miaskowski C, Cooper B, Paul SM, West C, Langford D, Levine JD, Abrams G, Hamolsky D, Dunn L, Dodd M, Neuhaus J, Baggott C, Dhruva A, Schmidt B, Cataldo J, Merriman J, Aouizerat BE. Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery. J Pain. 2012;13(12):1172-87. PMCID: PMC3511823. 9. Penko J, Mattson J, Miaskowski C, Kushel M. Do patients know they are on pain medication agreements? Results from a sample of high-risk patients on chronic opioid therapy. Pain Med. 2012;13(9):1174-80. PMCID: PMC3443332. 10.Humphreys J, Cooper BA, Miaskowski C. Occurrence, characteristics, and impact of chronic pain in formerly abused women. Violence Against Women. 2011;17(10):1327-43. 11.Miaskowski C, Penko JM, Guzman D, Mattson JE, Bangsberg DR, Kushel MB. Occurrence and characteristics of chronic pain in a community-based cohort of indigent adults living with HIV infection. J Pain. 2011;12(9):1004-16. PMCID: PMC3164738. 12.Miaskowski C. Effective pain management for older adults: a growing need. J Pain. 2011;12(3 Suppl 1):S1- 2.

Program Director/Principal Investigator (Last, First, Middle): 13.Langford DJ, Tripathy D, Paul SM, West C, Dodd MJ, Schumacher K, Miaskowski C. Trajectories of pain and analgesics in oncology outpatients with metastatic bone pain. J Pain. 2011;12(4):495-507. PMCID: PMC3073575. 14.Miaskowski C. Outcome measures to evaluate the effectiveness of pain management in older adults with cancer. Oncol Nurs Forum. 2010;37 Suppl:27-32. 15.Løyland B, Miaskowski C, Wahl AK, Rustøen T. Prevalence and characteristics of chronic pain among long- term social assistance recipients compared to the general population in Norway. Clin J Pain. 2010;26(7):624-30.

Ongoing Research Support

K05CA168960 (Miaskowski) 07/01/2013-06/30/2018 NIH/NCI Advancing the Science of Symptom Management in Oncology Patients An evaluation of similarities and differences in the trajectories of five common symptoms that occur as a result of cancer and/or its treatments (i.e., pain, fatigue, sleep disturbance, depression, anxiety). Role – PI

R01DA034625 (Knight) 06/01/2013-04/30/2017 NIH/NIDA Pain Management in Clinic & Community The proposed project is a qualitative study that will examine the factors that impact primary care providers’ and patients’ pain management practices in clinical settings and patients’ home communities. This study will target patients with a history of substance use (past or current) who access healthcare in low income, safety net clinic settings and their primary care providers. Study results will improve our understanding of the individual, interactive, and socio-cultural dimensions of chronic non-cancer pain management to inform future research and clinical practice. Role – Co-Investigator

R01 CA 134900 (Miaskowski, Multiple PI) 2009-2014 NIH/NCI Symptom Clusters in Oncology Patients Receiving Chemotherapy This study will address two important aspects of symptom cluster research, namely 1) the identification of symptom clusters in oncology outpatients who are receiving chemotherapy and 2) the identification of subgroups of oncology outpatients based on their experience with four highly prevalent symptoms (i.e., pain, fatigue, sleep disturbance, and depression). Based on our previous research, we anticipate that two subgroups of patients will be identified (i.e., patients who experience high levels of all 4 symptoms (approximately 10% of the sample) and patients who experience low levels of all 4 symptoms (approximately 43.0% of the sample). A two-stage genome wide association study will be done with the DNA from these two subgroups to identify genomic markers for these two distinct groups of patients. Role – Multiple PI

R01 CA151692 Miaskowski (PI) 09/09/2011-8/31/2016 NIH/NCI Characterization of and Treatment for Chemotherapy Neuropathy This study will be conducted in two parts. In Part 1, using a sample of patients with (n=400) and without (n=200) CIN who have completed CTX, differences in phenotypic (i.e., sensory characteristics, motor characteristics, mood, concurrent symptoms, balance, quality of life) and genotypic characteristics (i.e., candidate gene studies) will be evaluated. In Part 2, based on recent work from our group that demonstrated the efficacy of photon stimulation in improving sensation and quality of life in patients with painful diabetic peripheral neuropathy, we will conduct a pilot study to determine effect sizes for the effects of photon stimulation compared to placebo in improving light touch sensation, pain intensity, and pain qualities in oncology patients with CIN who have completed CTX. In addition, we will determine the feasibility of the treatment protocol and the safety of photon stimulation in patients with CIN.

Program Director/Principal Investigator (Last, First, Middle):

(Schumacher) 06/05/12-10/14/14 Altarum Institute(NIH subcontract ) Interprofessional development of pain education competencies To establish a detailed roadmap of pain curriculum for each of the four UCSF professional schools (Medicine, Pharmacy, Nursing, Dentistry) followed by a coordinated effort to build on and integrate case-based pain content into existing curriculum and competency-based assessments. Role: Co-I

Completed Research Support

R01 DA 022550 (Kushel) 09/30/07-04/30/2010 NIH/NIDA Pain and Misuse of Prescription Opioids in a Community-Based HIV-Infected Cohort The specific aims of this study, in a community-based sample of persons infected with HIV are to: determine the prevalence, characteristics and variability of pain in those who do and do not have a history of substance abuse; to determine whether control of pain is predicted by the site of pain treatment and the use of pain contracts; and determine predictors of aberrant opiaid analgesic behaviors. Role - Co-Investigator

5 R21 NR010600 (Miaskowski) 09/14/07-05/31/10 NIH/NINR Symptom Clusters in Pediatric Oncology Patients The specific aims of this project are to (1) identify the prevalence, severity, frequency, and distress of single symptoms that occur acutely, (2) identify the number and types of symptom clusters that occur acutely, (3) determine if the number and types of symptom clusters change over the course of one cycle of CTX, and (4) determine, at each time point, the association between the numbers of symptoms and symptom cluster “scores” identified in the analyses for Aims 1 and 2 with children’s reported QOL scores. Role: PI

5 R01 CA107091 Miaskowski (PI) 09/01/03-06/30/09 NIH/NCI Symptom Management After Breast Cancer Surgery The major goals of this project are to evaluate the prevalence, severity, and timing of the occurrence of breast symptoms following breast cancer surgery and to determine the factors that predict the development of breast symptoms. Role: PI

5 R01 CA118658 Miaskowski (PI) 9/01/06-07/31/11 NIH/NCI Long-Term Arm Morbidity Following Breast Cancer Treatment The specific aims of this study is to determine the prevalence, severity, and the timing of the lymphedema (LE); determine the prevalence and timing of occurrences of changes in shoulder mobility and changes in grip strength associated with LE; compare differences in anxiety, depressed mood, fatigue, sleep disturbance, functional status, and quality of life (QOL) in women who do and do not develop LE; and determine the factors that predict the development of LE. A secondary aim of this study is to begin to elucidate genetic markers for neuropathic pain and LE following breast cancer surgery. Role: PI

BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2. Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Nagarajan, Srikantan S., Ph.D. Professor eRA COMMONS USER NAME NAGARAJAN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) University of Madras, Madras, India B.E. 1985-1989 Electrical Engineering Case Western Reserve University, Cleveland, Ohio M.S. 1989-1991 Biomedical Engineering Case Western Reserve University, Cleveland, Ohio Ph.D. 1991-1995 Biomedical Engineering University of California, San Francisco, California Post-doc 1995-1998 Integrative Neuroscience

A. Personal Statement My training and experience as an integrative neuroscientist and biomedical engineer enables me to contribute in many ways to this grant proposal. Specifically, my research interests include study of brain plasticity since my postdoctoral fellowship in the laboratory of Dr. Michael Merzenich. Moreover, for the past several years I have been involved in the continued development and improvement of multimodal brain imaging methods such as fMRI, diffusion MRI, magnetoencephalography (MEG) and electroencephalography (EEG). I have been the Director of the Biomagnetic Imaging Laboratory at UCSF since 2002. For the past 4 years, I am also the Co- Director of the Brain Research Interest Group within the Department of Radiology and Biomedical Imaging, which spearheads and facilitates functional brain imaging projects within our department and collaborators.

I have extramural funding for my research from NIH, NSF and several private foundations. I have served as a mentor for several undergraduate students, graduate students, medical students, residents, clinical fellows and postdoctoral fellows. I currently hold membership in the joint UCSF/UCB Graduate Program in Bioengineering, and I serve on the program’s Executive Committee. I have mentored several graduate students in the Department of Physical Therapy (both DPT and DPTSci), and I look forward to mentoring many more students through my continued participation in this Ph.D. program.

B. Positions 1995-1998 Post-doctoral fellow, Keck Center for Integrative Neuroscience, UCSF 1998-1999 Research Scientist, Scientific Learning Corporation, Berkeley, California 1999-2000 Adj. Assistant Prof., Department of Otolaryngology, University of California, San Francisco 2000-2002 Assistant Professor, Depart. of Bioengineering, Radiology & Neuroscience, University of Utah 2000-2002 Director, Functional Brain Imaging Laboratory, University of Utah, Salt Lake City 2002-2004 Assistant Professor, Department of Radiology, UCSF 2002-present Director, Biomagnetic Imaging Laboratory, UCSF 2004-2008 Associate Professor, Department of Radiology and Biomedical Imaging, UCSF 2008-present Professor, Department of Radiology, UCSF Study Section and Public Advisory Committee Memberships 2002,3,8,10 Member of NSF Panel on Cognitive Neuroscience 2004 Ad-Hoc Member of Special Emphasis Panels: NLM, mBIRN, IFCN 2005 Ad-Hoc Member of Study Section ZRG1 MDCN-K 2005 Ad-Hoc Member of VA Study Section 2006 Ad-Hoc Member of NIH Study Section BMIT 2007-8 Reviewer for AAAS – LSD Program 2007 Reviewer for Tinnitus Study Section (ZDC1 SRB-R) 2008-12 Member of Study Section COG/SPC 2009 Adhoc Member of Study Section ZRG-ETTN-C53

Honors/Awards 1991,93 Student Paper Finalist, IEEE-EMBS Conference 2007 Senior Member, IEEE 2009 Associate Editor for Frontiers in Human Neuroscience, Brain Imaging Methods 2010-present Editorial Board Member for Neuroimage 2011 Editors Choice award for Neuroimage Methods paper 2013 Distinguished Investigator of American Academy of Radiology Research C. Selected Peer Reviewed Publications (from >100 published full-length papers) 1. Nagarajan, S.S., Attias H.T., Hild K.E., Sekihara K., A Graphical Model for Estimating Stimulus-Evoked Brain Responses in Noisy MEG data with Large Background Brain Activity, Neuroimage. 2006 Apr 1;30(2):400-16. PubMed PMID: 16360320. 2. Nagarajan, S.S., Attias H.T., Hild K.E., Sekihara K., A Probabilistic Algorithm for Robust Interference Suppression in Bioelectromagnetic data, Stat Med. 2007 Sep 20;26(21):3886-910 PubMed PMID: 17546712. 3. Zumer J.M, Attias H.T, Sekihara K and Nagarajan S.S, “A probabilistic algorithm for interference suppression and source reconstruction from MEG/EEG data”, Neuroimage, 37(1):102-115, 2007 PubMed PMID: 17574444 4. Wipf D, Nagarajan SS. A unified Bayesian framework for MEG/EEG source imaging. Neuroimage. 2009 Feb 1;44(3):947-66. Epub 2008 Mar 18. PubMed PMID: 18602278. 5. Wipf DP, Owen JP, Attias HT, Sekihara K, Nagarajan SS. Robust Bayesian estimation of the location, orientation, and time course of multiple correlated neural sources using MEG. Neuroimage. 2010 Jan 1;49(1):641-55. Epub 2009 Jul 10. PubMed PMID: 19596072. 6. Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Berger MS, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. Neuroimage. 2008 May 1;40(4):1686-700. Epub 2008 Jan 31. PubMed PMID: 18356081; PubMed Central PMCID: PMC2426929. 7. Guggisberg AG, Honma SM, Findlay AM, Dalal SS, Kirsch HE, Berger MS, Nagarajan SS. Mapping functional connectivity in patients with brain lesions. Ann Neurol. 2008 Feb;63(2):193-203. PubMed PMID: 17894381. 8. Zumer, J., Attias, HT, Sekihara, K and Nagarajan SS, “Probabilistic algorithm for MEG/EEG imaging using temporal basis functions learned from data”, Neuroimage, 2008 Jul 1;41(3):924-40. PubMed PMID: 18455439 9. Limpiti T, Van Veen BD, Attias HT, Nagarajan SS. A spatiotemporal framework for estimating trial-to-trial amplitude variation in event-related MEG/EEG. IEEE Trans Biomed Eng. 2009 Mar;56(3):633-45. Epub 2008 Oct 31. PubMed PMID: 19272883; PubMed Central PMCID: PMC2756105. 10. Wipf DP and Nagarajan SS. Journal of Selected Topics in Signal Processing (Special Issue on Compressive Sensing). Iterative Reweighted L1 and L2 and Methods for Finding Sparse Solutions. 2010; 2(4). 11. Wipf D, Rao, B and Nagarajan SS, Latent Variable Bayesian Models for promoting sparsity, IEEE Transactions in Information Theory, 2011, Vol. 57, Issue: 9 : 6236 - 6255 12. Sekihara K, Owen JP, Trisno S, Nagarajan SS. Removal of spurious coherence in MEG source-space coherence analysis. IEEE Trans Biomed Eng. 2011 Nov; 58(11):3121-9. 13. Brookes MJ, Hale JR, Zumer JM, Stevenson CM, Francis ST, Barnes GR, Owen JP, Morris PG, Nagarajan SS. Measuring functional connectivity using MEG: Methodology and comparison with fcMRI. Neuroimage. 2011 Jun 1;56(3):1082-104. Epub 2011 Feb 23. PubMed PMID: 21352925. 14. Chang EF, Niziolek CA, Knight RT, Nagarajan SS, Houde JF. Human cortical sensorimotor network underlying feedback control of vocal pitch. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2653-8. PubMed PMID: 23345447; PubMed Central PMCID: PMC3574939. 15. Herman AB, Houde JF, Vinogradov S, Nagarajan SS. Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction. J Neurosci. 2013 Mar 27;33(13):5439-53. PubMed PMID: 23536060; PubMed Central PMCID: PMC3711632.

D. Research Support (current)

R21 NS76171 09/1/12-08/14 Fusion of Electromagnetic Brain Imaging and fMRI Role: Principal Investigator 2 calendar months Direct costs: 150K for Year 1, 125K for Year 2 The goal of this application is to develop new algorithms for fusing of fMRI and MEG data.

BCS 1262297 07/01/2013 - 06/30/2016 Function of Auditory Feedback Processing During Speech NSF Cognitive Neuroscience Program Role: PI The goals of this grant are to examine feature and category specificity in auditory cortical representations during speaking. There is no overlap with experiments in this NSF proposal and the current grant.

R01 DC010145 (PI: Houde) 07/01/2010-6/30/15 Neuroimaging of speech motor control NIH/NIDCD $250,000/yr direct costs Role: Co-Investigator 3 calendar months The goal of this grant is to develop and test a new model of speech motor control using MEG and ECoG. Although this grant is in the same research topic, no experiment proposed in this grant overlaps with those proposed in the current application.

R01 NS067962-01 12/1/2009-11/30/2014 Multimodal Connectivity for Surgical Mapping NIH/NINDS $215,000/yr Role: Co-investigator (PI: Roland Henry) 1 calendar month The goals of this grant are to improve preoperative delineation of cortical and white matter regions that are vital to motor function, and to use functional and structural connectivity to predict those cortical and subserving white matter pathways at risk for postoperative clinical deficits.

Simons Foundation (PI: Sherr) 08/01/10-07/31/13 Simons Variation in Individuals Project The project will intensively study hundreds of patients and their families with 16p11.2 deletions and duplications. Patients will come to UCSF for comprehensive imaging and psychometric investigation. Role: Co-Investigator

DOD/CDMRP 07/01/2013 - 06/30/2015 Tinnitus Multimodal Imaging Role: Co-Investigator (PI: Dr. Steven Cheung) The goals of this project are to examine multimodal imaging data in patients with tinnitus.

Completed R01 DC006435 12/01/2004-11/30/12 Neural mechanisms of auditory feedback during speaking NIH/NIDCD $250,000/yr direct costs Role: PI The goal of this grant was to develop and test a novel state-feedback network control model on processing of feedback during speech.

R01DC004855 6/1/2001-5/31/2013 Cortical Spatiotemporal Plasticity in humans NIH/NIDCD $215,000/yr direct cost Role: PI

The goals of this grant were to use MEG based imaging to document cortical plasticity associated with auditory perceptual learning.

NSF BCS0926196 10/1/2009-4/30/2013 Using Neuroimaging to test models of speech motor control NSF Cognitive Neuroscience Program $150,000/yr direct costs Role: Co-PI (PI: Dr. John Houde) The goals of this research were to conduct speech feedback perturbation experiments using MEG and ECoG to test models of speech motor control. This grant was focused on pitch perturbation studies.

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE LINDA J NOBLE, Ph.D. PROFESSOR eRA COMMONS USER NAME (credential, e.g., agency login) lnoble EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Nevada, Reno, Nevada B.S. 06/75 Prephysical Therapy University of Utah, Salt Lake City, Utah B.S. 06/75 Physical Therapy University of California, Los Angeles, California Ph.D. 05/82 Anatomy

A. Personal Statement I have studied brain and spinal cord injury for well over 2 decades with funding provided by NINDS, private foundations and the Department of Defense. This research has supported medical students, graduate students and postdoctoral fellows. I currently hold memberships in the Neuroscience Graduate Program and the Biomedical Graduate Program where I have participated in journal club presentations, oral examinations, and rotations of graduate students through my laboratory. In addition, I direct research for all graduate students in the Department of Physical Therapy and Rehabilitation Science and serve as a research mentor for on average 6 of these graduate students annually. I am co-director of the Neurobehavioral Core, which provides the necessary infrastructure to conduct a wide range of behavioral assays in mice. An objective of this Core is to educate about behavioral paradigms and as such, I oversee a “boot camp” class for the incoming neuroscience graduate students. The Core also provides small group tutorials that attract the remainder of the research community including graduate and postdoctoral students and faculty. Finally, I initiated a new mini course this past fall on Brain Injury that was open to graduate students, postdoctoral fellows, residents, and technicians. Representatives from each of these groups attended this 2-week course that offered an intensive overview of brain injury from the perspective of pathobiology to preclinical design to successful translation to the clinic. B. Positions and Honors Positions and Employment

1975-1976 Physical Therapist, Cedars-Sinai Medical Center, Los Angeles 1977-1978 Physical Therapist, University of California, Los Angeles 1977-1982 Predoctoral Fellow, Department of Anatomy, University of California, Los Angeles 1982-1983 Instructor, Department of Anatomy, University of Maryland, Baltimore 1983-1985 Research Associate, Department of Anatomy, Georgetown University, Washington, D.C. 1985-1990 Assistant Research Neuroanatomist, Department of Neurology, UCSF 1990-1993 Assistant Professor, Department of Neurosurgery, UCSF 1994-1999 Associate Professor, Department of Neurosurgery, UCSF 2000-2003 Professor and Vice Chair, Department of Neurosurgery, UCSF 2003- Professor and Alvera Kan Endowed Chair, Department of Neurosurgery, UCSF 2007- Professor, Department of Physical Therapy and Rehabilitation Science, UCSF

Other Experience and Professional Memberships

1980- Member, Society for Neuroscience 1980- Member, National Neurotrauma Society 1993-1997 Member NINDS Neurology B1 Study Section 1996-1997 Chair NINDS Neurology B1 Study Section 1998-2007 Ad hoc reviewer, NINDS

2007-2008 Member, Committee on Gulf War and Health: Brain Injury in Veterans and Long-Term Health Outcomes, Institute of Medicine of the National Academies 2010-11 Member, Committee on Nutrition, Trauma, and the Brain, Institute of Medicine of the National Academies 2009 NINDS, NSDA study section 2010 Chair, NINDS, NSDA study section 2012-13 Member, Committee on Gulf War and Health: Long-term effects of blast exposures, Institute of Medicine of the National Academies

Peer-reviewed Publications 1. Noble L J and Maxwell DS. Blood-spinal cord barrier response to transection. Exp Neurology. 79:188- 199. 1983 2. Noble L J and Maxwell DS. Morphometric analysis of effects of spinal cord transection. Exp Neurology. 79:200-211. 1983 3. Noble L J and Wrathall JR. Spinal cord contusion in the rat: morphometric analysis of alterations in the spinal cord. Exp Neurology. 88:135-149. 1985 4. Noble L J and Wrathall JR. An inexpensive apparatus for producing graded spinal cord contusive injury in the rat. Exp Neurology. 95:530-533. 1987 5. Noble L J and Wrathall JR. The blood-spinal cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat. Brain Research. 424:177-188. 1987 6. McIntosh TK, Noble L J, Andrews BA, and Faden AI. Traumatic brain injury in the rat: characterization of a midline fluid percussion model. CNS Trauma. 4:119-134. 1987 7. Noble L J and Wrathall JR. Blood-spinal cord barrier disruption proximal to a spinal cord transection: time course and pathways associated with protein leakage. Exp Neurology. 99:567-578. 1988 8. Faden, AI, Sacksen I, and Noble L J. Structure activity relationships of TRH analogs in rat spinal cord injury. Brain Research. 448:287-293. 1988 9. Faden AI, Sacksen I, and Noble L J. Opiate-receptor antagonist nalmefene improves neurological recovery after traumatic spinal cord injury in rats through a central mechanism. J Pharmacol Exp Ther. 245:742-748. 1988 10. Faden AI, Lemke M, Simon R, and Noble L J. N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic and neurochemical studies. J Neurotrauma. 5:33-45. 1988 11. McIntosh TK, Vink R, Noble L J, Yamakami I, Fernyak S, Soares H, and Faden AI. Traumatic brain injury in the rat: characterization of a lateral fluid percussion model. Neuroscience. 28:233-244. 1989 12. Noble L J and Wrathall JR. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurology. 103:34-40. 1989 13. Vink R, Noble L J, Knoblach S, Bendall MR, and Faden AI. Metabolic changes in rabbit spinal cord after trauma: NMR spectroscopy studies. Ann Neurology. 25:26-31. 1989 14. Noble L J and Wrathall JR. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Research. 482:57-66. 1989 15. Cortez S, McIntosh T, and Noble L J. Experimental fluid percussion brain injury; vascular disruption and neuronal and glial alterations. Brain Research. 482:271-282. 1989 16. Noble L J, and Ellison J. Effect of transection on the blood-spinal cord barrier of the rat after isolation from descending sources. Brain Research. 487:299-310. 1989 17. Faden AI, Ellison J, and Noble L J. Effects of competitive and non-competitive N-methyl-D-aspartate antagonists in experimental spinal cord injury. Eur J Pharmacol. 175:165-174. 1990 18. Noble L J, Cortez S, and Ellison JA. Endogenous peroxidatic activity in astrocytes after spinal cord injury. J Comp Neurol. 296:674-685. 1990 19. Dux E, Noble L J, and Chan PH. Glutamine stimulates growth in rat cerebral endothelial cell culture. J Neuroscience Res. 29:355-361. 1991 20. Sharp F, Jasper P, Hall J, Noble L J, and Sagar SM. MK801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurology. 30:801-809. 1991

21. Tanno H, Nockels R, Pitts L, and Noble L J. Breakdown of the blood-brain barrier after fluid percussive head injury in the rat. Part 1. Distribution and time course of protein extravasation. J Neurotrauma. 9:21-32. 1992 22. Noble L J, Hall JJ, Chen S and Chan PH. Morphologic changes in cultured astrocytes after exposure to glutamate. J Neurotrauma. 9: 255-267. 1992 23. Tanno H, Nockels R, Pitts L and Noble L J. Breakdown of the blood-brain barrier after fluid percussive head injury in the rat. Part 2. Effect of hypoxia on permeability to plasma proteins. J Neurotrauma. 9:335-347. 1992 24. Sharp FR, Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Noble L, Berger P and Longo FM. Haloperidol prevents induction of the 70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, ketamine. J Neuroscience Res. 33:605-616. 1992 25. Tanno H, Nockels RP, Pitts L, and Noble L J. Immunolocalization of heat shock protein after fluid percussive brain injury and relationship to breakdown of the blood-brain barrier. JCBF. 13:116-124. 1993 26. Aihara N, Tanno H, Hall JJ, Pitts LH, and Noble L J. Immunocytochemical localization of immunoglobulins in the rat brain: Relationship to the blood-brain barrier. J Comp Neurol. 342:481-496. 1994 27. Noble, LJ, Kalinyak JE, Pitts LH, and Hall JJ. Fluid-phase endocytosis of horseradish peroxidase by cerebral endothelial cells in primary culture. Characterization and kinetic analysis. J Neuroscience Res. 38:654-663. 1994 28. Aihara N, Hall J, Pitts LH, Fukuda K, and Noble L J. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma. 12:53-63. 1995 29. McKenzie A, Hall J, Aihara N, Fukuda K, and Noble L J. Immunolocalization of endothelin in the traumatized spinal cord: Relationship to blood-spinal cord barrier breakdown. J Neurotrauma. 12:257- 268. 1995 30. Westmark R, Noble L J, Fukuda K, Aihara N, and McKenzie A. Intrathecal administration of endothelin-1 in the rat: Impact on spinal cord blood flow and the blood-spinal cord barrier. Neuroscience Lett. 192:173-176. 1995 31. 30, Fukuda K, Panter SS, Sharp F, and Noble L J. Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat. Neuroscience Lett. 199: 127-130. 1995 32. Richmon J, Fukuda K, Sharp F, and Noble L J. Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neurosci Lett. 202:1-4. 1995 33. Yibing L, Huang T, Carlson E, Melov S, Ursell P, Olson J, Noble L J, Yoshimura M, Berger C, Chan P, Wallace D, and Epstein C. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature. 11:376-381. 1995 34. Fukuda K, Aihara N, Sagar S, Pitts L, Sharp F, Honkaniemi J, and Noble L J. Purkinje cell vulnerability to mild traumatic brain injury. J Neurotrauma. 13:255-266. 1996 35. Fukuda K, Richmon J, Sato M, Sharp F, Panter S, and Noble L J. Induction of heme oxygenase-1 in glia after traumatic brain injury. Brain Research. 736:68-75. 1996 36. Mautes AEM, Fukuda K, and Noble L J. Cellular response in the cerebellum after midline traumatic brain injury in the rat. Neuroscience Lett. 214:95-98. 1996 37. Kim D, Gutin P, Noble L J, Nathan D, Yu J, and Nockels R. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. NeuroReport. 7:2221-2225. 1996 38. Basso D, Beattie M, Bresnahan J, Anderson D, Faden A, Gruner J, Holford T, Hsu C, Noble L J, Nockels R, Perot P, Salzman S, and Young W. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 13:343-59. 1996 39. Noble L J, Mautes A, and Hall JJ. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol. 376:542-556. 1996 40. Cobbs C, Fenoy A, Bredt D, and Noble L J. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Research. 751:336-338. 1997 41. Beattie M, Bresnahan J, Komon J, Tovar A, Van Meter M, Anderson K, Faden A, Hsu C, Noble L J, Salzman S, and Young W. Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurology. 148:453-63. 1997

42. Richmon J, Fukuda K, Maida M, Sato M., Bergeron M, Sharp F, Panter S, and Noble L J. Induction of heme oxygenase-1 after hyperosmotic opening of the blood brain barrier. Brain Research. 780:108- 118. 1998 43. Turner C, Bergeron M, Matz P, Zegna A, Noble L J, Panter SS, and Sharp F. HemeOxygenase-1 (HO-1) is induced in microglia throughout brain by subarachnoid hemoglobin. JCBF. 18:257-73. 1998 44. Mautes A, Kim D, Sharp F, Panter S, Sato M, Maida N, Bergeron M, Guenther K, and Noble L J. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat. Brain Research. 795:17- 24. 1998 45. Sato M, and Noble L J. Involvement of the endothelin receptor subtype A in neuronal pathogenesis after traumatic brain injury. Brain Research. 809:39-49. 1998 46. Mautes A, Weinzierl M, Donovan F, and Noble L J. Vascular Events After Spinal Cord Injury: Contribution to Secondary Pathogenesis. Physical Therapy. 80:673-685. 2000 47. Mautes A, Bergeron M, Sharp F, Panter S, Weinzierl M, Guenther K, and Noble L J. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurology. 166:254265. 2000 48. Mautes A and Noble L J. Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat. Brain Research. 883:233237. 2000 49. Sheldon A, Hall J, Noble L J, and Ferriero D. Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic. Neuroscience Letters. 304:165-8. 2001 50. Sato M, Chang E, Igarashi, T and Noble L J. Patterns of acute and delayed neuronal injury after mild traumatic brain injury. Brain Research. 917:45-54. 2001 51. Igarashi T, Huang T, and Noble L J. Regional vulnerability after traumatic brain injury: Gender differences in mice that overexpress human copper, zinc superoxide dismutase. Exp Neurology. 172:332-341. 2001 52. Noble L J, Donovan F, Igarashi T, Goussev S, and Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events J. Neuroscience. 22 7526- 7535. 2002 53. Tong W, Igarashi T, Ferriero D, and Noble L J. Traumatic brain injury in the immature mouse brain: Characterization and regional vulnerability. Exp Neurology. 176:105-116. 2002 54. Weinzierl M, Mautes AE, Lin Y, and Noble L J. Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase. Neuroscience Letters. 336:13-16. 2003 55. Fan P, Yamauchi T, Noble L J, and Ferriero DM. Age-dependent susceptibility to oxidative stress after traumatic brain injury in the immature brain. J Neurotrauma. 20:437-45. 2003 56. Chang E, Wong R, Vreman H, Galo E, Sharp F, Igarashi T, Stevenson D, and Noble-Haeusslein L J. Heme oxygenase protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neuroscience. 23:3689-96. 2003 57. Whetstone W, Eisenberg M, Werb Z, and Noble-Haeusslein LJ. The blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing. J Neuroscience Res. 74:227-239. 2003 58. Luk H, Noble L J, and Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neuroscience Res. 73:644-658, 2003. 59. Goussev S, Hsu J-Y, Lin Y, Tjoa T, Maida N, Werb Z, and Noble-Haeusslein, L J. Differential temporal expression of matrix metalloproteinases after spinal cord injury: Relationship to revascularization and wound healing. J Neurosurg. 99(2 Suppl):188-97. 2003 60. Tjoa T, Strausbaugh H, Maida N, Rosen S, and Noble-Haeusslein, L J. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neuroscience Methods. 129:49-59. 2003 61. Fiore C, Inman D, Hirose S, Noble L J, Igarashi T, and Compagnone N. Treatment with the neurosteroid dehydroepiandrosterone (DHEA) promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neuroscience Res. 75:391-400. 2004 62. Yamauchi T, Lin Y, Sharp F, and Noble-Haeusslein L J. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 21:1017-30. 2004

63. Weinzierl M, Mautes AE, Whetstone W, Lin Y, and Noble-Haeusslein L J. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Research. 1030:125-32. 2004 64. McLean C, Mirochnitchenko O., Claus C, Noble-Haeusslein L J, and Ferriero D. Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress. Dev Neuroscience. 27:169-75. 2005 65. Chang E, Claus C, and Noble-Haeusslein L J. Regulation of heme after traumatic brain injury: The role of heme oxygenases. JCBF. 27:169-75. 2005 66. Trivedi A, Hsu J-Y,Lin Y, Goussev S,Gan J,Topp S, and Noble-Haeusslein L J. The effects of acute and extended inhibition of matrix metalloproteinases on demyelination and functional recovery after spinal cord injury. Int J Neuroprotection and Neuroregeneration. 2:30-38. 2005 67. Trivedi A, Igarashi T, Compagnone N, Fan X, Hsu J, Hall D, John C, and Noble-Haeusslein L. Allogenic sertoli cells as a vehicle for the delivery of human neurotrophin-3 to the injured spinal cord. Exp Neurology. 198:88-100. 2006 68. Potts M, Koh, S-E, Whetstone W, Walker B, Yoneyama T, Claus C, Manvelyan H, and Noble- Haeusslein L J. Traumatic injury to the developing brain: Strategies to limit early damage and restore function. NeuroRx. 3:143-53. 2006 69. Trivedi A, Olivas A, and Noble-Haeusslein LJ. Inflammation and spinal cord injury: Infiltrating leukocytes as determinants of injury and repair processes. Clin Neuroscience Res. 83-292, 2006 70. Rola R, Mizumatsu S, Otsuka S, Morhardt D, Noble-Haeusslein LJ, Potts MB, Fike JR. Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp Neurology. 202:189-199. 2006 71. Pulella R, Raber J, Ferriero D, Claus C, Koh S, Yamauchi T, Rola R, Fike J, and Noble-Haeusslein LJ. Traumatic injury to the developing brain results in progressive neuronal loss, hyperactivity, and delayed cognitive impairments. Dev Neuroscience. 28:396-409, 2006 72. Hsu J-Y, McKeon R, Goussev S, Werb Z, Lee J-E, Trivedi A, and Noble-Haeusslein LJ. Matrix metalloproteinase-2 deficiency results in wound healing events that limit functional recovery after spinal cord injury. J Neuroscience. 26:9841-50. 2006 73. Lin Y, Vreman HJ, Wong RJ, Tjoson T, Yamauchi T, Noble-Haeusslein L J. Heme Oxygenase-1 stabilizes the blood-spinal cord barrier and attenuates white matter damage in the acutely contused murine spinal cord. JCBF. 27:1010-21, 2007 74. Igarashi T, Potts M, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurology. 203: 258-268. 2007 75. Boyd B, Puttlitz C, Noble-Haeusslein L, John C, Trivedi A, Topp K. Deviations in gait pattern in experimental models of hindlimb paresis demonstrated by a novel pressure mapping system. J Neuroscience Res. 85:2272-83, 2007 76. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble- Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neuroscience. 28:13467-77, 2008. 77. Potts M, Rola R, Claus C, Ferriero D, Fike J, Noble-Haeusslein L. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neuroscience Res. 87:1848-57. 2009. 78. Kyoko Tsuru-Aoyagi K, Potts M, M.D.1, Trivedi A, Phankuch T, Raber J, Wendland M, Claus C, Koh S, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Annals of Neurology. 18:540-549, 2009. 79. Margulies S, Hicks R, and the Traumatic Brain Injury Workshop Leaders including Ansel B, Bullock R, Clifford D, Clifton G, Conwit R, Dash P, Diaz-Arrastia R, Dietrich D, Dunn B, Emerson S, Fertig S, Hall E, Hoyt D, Janis S, Koroshetz W, Laskowitz D, Meaney D, Morrison B, Noble L, Povlishock, Robertson C, Soares H, Sopko G, Sullivan P, Weinrich M, Wright D, Zafonte Z. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 26:925-939, 2009. 80. Potts M, Adwanikar H, Noble-Haeusslein L. Models of traumatic cerebellar injury. Cerebellum. 8:211- 221, 2009. 81. Rutherford G, Bazarian J, Cernak I, Dikman S, Grady S, Hesdorffer D, Kraus J, Levin H, Noble L, Potolicchio S, Rauch S, Stiers W, Tamminga C, Temkin N, Weisskopf. Gulf War and Health. Volume 7. Long-term Consequences of Traumatic Brain Injury. Institute of Medicine of the National Academies. 2009.

82. Bazarian J, Cernak I, Noble-Haeusslein L, Potolicchio S, Temkin N. Long-term neurologic outcomes after traumatic brain injury. Journal of Head Trauma Rehabilitation, 24:439-51, 2009. 83. Cernak I and Noble-Haeusslein LJ. Traumatic Brain Injury: An Overview of Pathobiology with Emphasis on Military Populations. JCBF. 30:255-66, 2010. 84. Zhang H, Adwanikar H, Werb Z, and Noble-Haeusslein LJ. 2010. Matrix metalloproteinases and Neurotrauma: Evolving roles in injury and reparative processes. Neuroscientist. 16:156-70, 2010. 85. Yoneyama-Sarnecky T, Olivas A, Azaria S, Ferriero DM, Manveylan H, Noble-Haeusslein LJ. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neuroscience. 32:81-90, 2010. 86. Mao H, Jin X, Zhang L, Yang K, Igarashi, T, Noble-Haeusslein LJ, and King A. Finite element analysis of controlled cortical impact injury- Investigation of intracranial tissue biomechanics. J Neurotrauma 2010; 27(5):877-88. 87. Claus C, Tsuru-Aoyagi K, Adwanikar H, Walker B, Whetstone W, Noble-Haeusslein LJ. Age is a determinant of the inflammatory response and loss of cortical volume after traumatic brain injury. Dev Neuroscience. 32:454-65, 2010. 88. Chui K, Trivedi A, Cheng C, Cherbavaz D, Dazin P, Huyhn A, Mitchell J, Rabinovich G, Noble- Haeusslein LJ, and John C. Characterization and functionality of proliferative human sertoli cells. Cell Transplantation. 20:619-35, 2011 89. Wang Y, Neumann M, Hansen K, Hong S, Kim S, Noble-Haeusslein LJ, Liu J. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma 28:259-268, 2011 90. Levine J, Levine G, Porter B, Topp K, Noble-Haeusslein LJ. Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J Neurotrauma. 28:675-88 2011 91. Zhang H, Chang M, Hansen C, Basso DM, Noble-Haeusslein LJ. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics. 8:206-220, 2011 92. Chui K, Trivedi A, Cheng C, Cherbavaz D, Dazin P, Huyhn A, Mitchell J, Rabinovich G, Noble- Haeusslein LJ, and John C. Characterization and functionality of proliferative human sertoli cells. Cell Transplantation. In Press, 2011 93. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocytes recruitment promotes recovery after spinal cord injury. J. Neurotrauma. 28:1893-907, 2011 94. Zhang H, Trivedi A, Lee J, Lohela M, Lee, SM, Fandel T, Werb Z, and Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood borne monocytes into the injured spinal cord. J. Neuroscience. 2:15894-903, 2011 95. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490:187-9, 2012 96. Semple BD, Canchola SA, and Noble-Haeusslein LJ. Deficits in social behavior emerge during development after pediatric brain injury in mice. J Neurotrauma. 29:2672-83, 2012 97. Lapchak PA, Zhang JH, and Noble-Haeusslein LJ. Rigor guidelines: Escalating stairs and steps for effective translational research. In submission, Translational Stroke Research.4:279-285, 2013 98. Mahuvakar A, Lee SM, Zhang H, and Noble-Haeusslein LJ. Neutrophils as determinants of vascular stability in the injured spinal cord. In submission, Translational Stroke Research 99. Semple BD, Blomgren K, Gimlin K, Ferriero DF, Noble-Haeusslein. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Progress in Neurobiology. In Press 100. Hansen CH, Fisher LC, Dibert RJ Jakeman L, Zhang H, Noble-Haeusslein LJ, White S, Basso DM. Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice. Journal of Neuroscience. 33:13101-11, 2013 101. Chen CY, Noble-Haeusslein LJ, Ferriero, DM, Semple BD. Traumatic injury to the immature frontal lobe. A new murine modle of long-term motor impairment in the absence of psychosocial or cognitive deficits. In Press, Developmental Neuroscience

D. Research Support ONGOING SUPPORT R01 NS050159 (PI) 03/31/2011 - 03/31/2014 NIH/NINDS Trauma To Developing Brain-Injury And Repair Mechanisms This grant explores the biologic basis for the unique vulnerability of the developing brain to traumatic brain injury.

W81XWH-11-1-0797 (PI) 09/01/2011 - 06/30/2014 DOD Matrix metalloproteinases as a therapeutic target to improve neurologic recovery after spinal cord injury The key objective in this grant is to define the mechanisms underlying matrix metalloproteinase-mediated secondary damage and to determine if time- dependent inhibition improves neurological outcome after spinal cord injury R01NS077767 (PI) 07/01/2011 - 06/30/2013 NIH/NINDS Determinants of vulnerability and recovery after trauma to the developing brain This grant examines the relationship between neutrophils and neutrophil elastase in mediating tissue damage to the injured developing brain and determines if blockade of this protease early after injury results in structural and functional recovery. W81XWH-12-1-0563 (PI) 09/30/2012 - 09/29/2015 DOD Targeting L-selectin to improve neurologic and urologic function after spinal cord injury This grant examines the preclinical efficacy of the anti-inflammatory diclofenac in supporting recovery after spinal cord injury through its ability to promote shedding of L-selectin from the surface of leukocytes. TR3-5606 (Co-Investigator, PI A Kriegstein) 12/01/2012 - 11/30/2015 CIRM Human ES cell-derived MGE inhibitory interneuron transplantation for spinal cord injury This grant will determine if transplantation of neurons that assume an inhibitory phenotype will reduced bladder spasticity after spinal cord injury Private Gift/UCSF (Co-PI with D Ferriero) 01/01/2013-12/31/2016 Exercise as a strategy to improve cognitive outcome in a murine model of repeated concussive insults This grant will develop a new model of concussion to the developing brain and will determine if repeat concussions alters long-term behavior and if exercise, initiated shortly after injury will improve long-term outcomes.

COMPLETED RESEARCH

RC1 NS068200 (Shared PI) 05/08/2009 - 07/31/2012 NIH/NINDS Spinal cord injury: Targeting local inhibition to improve outcome

R01 NS039728 (PI) 07/27/2009 - 06/30/2012 NIH/NINDS Matrix metalloproteinases and spinal cord injury

R21 NS065937 (Shared PI) 05/08/2009 - 07/31/2012 NIH/NINDS Trauma to developing brain: Model refinement and therapeutic intervention

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Sandra Radtka, PT, PhD Professor, San Francisco State University (SFSU), eRA COMMONS USER NAME Department of Physical Therapy; Clinical Professor, UCSF, Department of Physical Therapy & Rehabilitation Sciences

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Michigan, Ann Arbor, MI BS 1974 Physical Therapy

Physical Therapy University of North Carolina, Chapel Hill, NC MA 1977 (Pediatrics & Clinical Education)

University of California, Berkeley, CA PhD 1985 Higher Education

Shriner’s Hospital for Children, Orthopedic Post- 1991-1993 Research Fellow Biomechanics Lab, San Francisco, CA doctoral training

A. Personal Statement

Dr. Radtka is Professor in the joint UCSF/SFSU Graduate Program in Physical Therapy where she currently teaches PT management of children with neurologic disorders and human growth and development across the lifespan. She previously taught PT management of adults with neurologic disorders. She is the Director of SFSU’s PT Movement Research Laboratory where she conducts biomechanics research using motion analysis, force plates, and electromyography. Her biomechanics research has examined the: 1. kinetics, kinematics and muscle activity during gait with and without lower extremity orthotics in cerebral palsy; 2. effects of neurodevelopment treatment interventions on sitting balance in cerebral palsy; and 3. kinetics and kinematics during sitting balance in healthy children and adults, children with cerebral palsy and hemiplegia from stroke and traumatic brain injury. These research studies have been supported by funding from the Eva Benson Buck Trust. She has also served as a consultant for a NIH funded grant examining the effects of balanced-based torso-weighting in multiple sclerosis in this lab and for a NIH funded grant on a computer- based video game therapy for gait and balance in cerebral palsy.

B. Positions and Honors

Positions and Employment (Academic) 1979-1981 Instructor, School of Physical Therapy, Texas Woman's University, Denton, Texas 1984 Lecturer, Graduate Program in Physical Therapy, Stanford University, Palo Alto, California 1986-1993 Assistant Clinical Professor, Graduate Program in Physical Therapy, University of California at San Francisco 1993-1999 Associate Clinical Professor, Graduate Program in Physical Therapy, University of California at San Francisco 1999-2005 Associate Professor, Graduate Program in Physical Therapy, San Francisco State University 1999-2006 Associate Clinical Professor (without salary), Dept. of Physical Therapy and Rehabilitation Sciences, University of California at San Francisco 2007-2014 Clinical Professor (without salary), Dept. of Physical Therapy and Rehabilitation Sciences, University of California at San Francisco 2006-2014 Professor, Graduate Program in Physical Therapy, San Francisco State University Other Experiences and Professional Memberships 1973-2014 Member, American Physical Therapy Association 1992-2014 Fellow, American Academy for Cerebral Palsy and Developmental Medicine 1997-2014 Member, North American Society of Gait and Clinical Movement Analysis

Honors 1983 Physical Therapy Foundation Graduate Award 1991 Shriner's Research Fellowship Award 1997 Faculty Publication Award, California Chapter, American Physical Therapy Association 2004 Presidential Award for Professional Development, San Francisco State University

C. Peer-reviewed Publications

1. Radtka S, Hone R, Brown C, Mastick J, Melnick M, Dowling G. Feasibility of Computer-Based Videogame Therapy for Children with Cerebral Palsy. Games for Health Journal 2(4):1-7, 2013 2. Gorman S, Radtka S, Melnick M, Abrams G, Byl N. Development and Validation of the Function In Sitting in Adults with Acute Stroke. Journal of Neurologic Physical Therapy 34:150-160, 2010 3. Radtka S, Oliveira G, Eldred K, Borders M: The Effects of Solid, Hinged, and No Ankle Foot Orthoses on Lower Extremity Kinematics and Kinetics During Stair Climbing in Healthy Adults. Gait and Posture 24:211- 218, 2006 4. Johanson ME, Radtka S: Amplitude Threshold Criteria Improve Surface Electrode Specificity During Walking and Functional Movements. Gait and Posture 24:429-434, 2006 5. Radtka S, Skinner S, Johanson ME: A Comparison of Gait with Solid and Hinged Ankle-Foot Orthoses in Children with Spastic Diplegic Cerebral Palsy. Gait and Posture 12:303-310, 2005 6. Melnick M, Radtka S, Alsbury N, Peterson J, Pisenti M, Christine C, Starr P, Marks W: The Effects of Unilateral Deep Brain Stimulation on Gait in Patients with Parkinson’s Disease. Movement Disorders 15:64, 2000 7. Bank J, Denton M, Hannemann C, Rose J, Radtka S: Employers' Perceptions of New Graduate Physical Therapists: Baccalaureate versus Postbaccalaureate Level of Education. Journal of Physical Therapy Education 12:(1):30-40, 1998 8. Radtka S, Skinner S, Dixon D, Johanson ME: A Comparison of Gait with Solid and Dynamic Ankle-Foot Orthoses in Children with Spastic Cerebral Palsy. Physical Therapy 77:395-409, 1997 9. Radtka S: Predictors of Physical Therapy Faculty Job Turnover. Physical Therapy 73:243-253, 1993 10. Baldauf K, Swenson D, Mederios J, Radtka S: Clinical Assessment of Trunk Flexor Muscle Strength in Healthy Girls 3 to 7 Years of Age, Physical Therapy 64:1203-1208, 1984 11. Radtka S, Dragotta N, Needham S, Smith S, Tucker J: Texas Consortium for Physical Therapy Clinical Education - A Model for Interinstitutional Consortium Arrangements, Physical Therapy 63:971-974, 1983

D. Research Support 1. Shriner's Research Fellowship Grant for two projects. 1. Effects of Solid Versus Inhibitive Ankle-Foot Orthoses on Ambulation in Children with Spastic Cerebral Palsy; 2. Effects of Neurodevelopmental Therapy on Sitting and Kneeling Equilibrium Reactions in Children with Spastic Cerebral Palsy June 1991 to June 1993, Principal Investigator 2. Shriner's Research Grant. A Comparison of Gait with Hinged and Solid Ankle-Foot Orthoses in Spastic Cerebral Palsy, January 1994 to December 1995, Principal Investigator 3. Eva Benson Buck Trust. Motion Analysis and Electromyography Equipment for Physical Therapy Pathokinesiology Lab at San Francisco State University. December 1997 to December 1998, Co- Investigator with Marsha Melnick 4. Research and Professional Development Mini-Grant, San Francisco State University. The Effects of Solid, Hinged, and No Ankle Foot Orthoses on Stair Climbing in Children with Spastic Hemiplegic Cerebral Palsy, August 1999 to May 2000, Principal Investigator 5. Research and Professional Development Mini-Grant, San Francisco State University. The Effects of Solid, Hinged, and No Ankle Foot Orthoses on Lower Extremity Muscle Activity During Stair Climbing in Normal Adults, August 2000 to May 2001, Principal Investigator 6. Research and Professional Development Mini-Grant, San Francisco State University. Effectiveness of the Neuro-developmental Treatment Approach in Improving Gait and Sitting Balance in Children with Cerebral Palsy. August 2001 to May 2002, Principal Investigator 7. Eva Benson Buck Trust. Effectiveness of Physical Therapy Treatment in Improving Sitting Balance in Children with Spastic Cerebral Palsy. January 2003 to December 2004, Principle Investigator 8. Presidential Award for Professional Development of Probationary Faculty, San Francisco State University. Physical Therapy Treatment for Children with Spastic Cerebral Palsy, August 2004 to May 2005, Principal Investigator 9. Consultant for NIH Grant #1R41HD061155-01. Principal Investigator(s): Glenna Dowling, RN, PhD, UCSF School of Nursing and Robert Hone, Red Hill Studios. Project Title: Computer-based Video Game Therapy for Gait and Balance in Cerebral Palsy, 2009-2010 10. Consultant for NIH Grant #1R15HD066397-01. Principal Investigator(s): Diane Allen, PT, PhD, Gail Widener, PT, PhD, San Francisco State University/Samuel Merritt University. Project Title: Changes in Movement Ability Changes with Balance Based Torso Weighting in Patients with Multiple Sclerosis, 2010- 2013

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Susanna Rosi Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) Director of Neurocognitive Research, Brain and SusRosi Spinal Injury Center, BASIC EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Florence, Italy B.S. 06/1995 Science University of Florence, Italy Ph.D. 06/2000 Biological Sciences University of Florence, Italy Postdoctoral 2000-2001 Pharmacology Postdoctoral University of Arizona, Tucson, Arizona Research 2002-2006 Psychology Associate

A. Personal Statement One of the great honors and pleasures of being a faculty member at a research university is the opportunity to work with graduate students pursuing doctoral degree. I can think of nothing that keeps a researcher more intellectually active that having eager, interested graduate students with which to interact. It has therefore been my extremely good fortune to be part of the graduate program in Neuroscience and Biomedical Science and have had the opportunity to teach, mentor and supervise a number of students. I regularly participated in journal club presentations, oral examinations, and rotations of graduate students through my laboratory. I currently have a Neuroscience graduate student in thesis in my laboratory. I am the director and instructor of the Neuroscience course for the Doctor in Physical Therapy Students. I am also the director and instructor of a minicourse on Neuroinflammation for Neuroscience and BMS graduate students. My goal as mentor and PI in my lab is to prepare graduate students and postdoctoral to be an independent researcher. My research is focused on analyzing in detail how the innate immune system affects information processing and cognition from a cellular and network prospective. Currently in my laboratory in the Brain and Spinal Injury Center (BASIC) at UCSF I use different animal models of brain injury to study the molecular mechanism of altered neuronal function that lead to impaired cognition. My long term goal is to identify diagnostic tools for treatment of cognitive dysfunctions associated with brain injury. As director of Neurocognitive research at BASIC I develop and oversee behavioral tests for animals that are comparable to the cognitive tests used in the clinic. I have a demonstrated record of successful and productive research projects in an area of high relevance for chronic inflammatory disease and plasticity. My achievements have also been recognized by an accelerated promotion to Associate Professor and promotion to Director of Neurocognitive Research at the Brain and Spinal Injury Center.

B. Positions and Honors Positions and Employment 2000-2001 Postdoctoral Fellow, University of Florence, Italy 2002-2006 Postdoctoral Research Associate, University of Arizona, Tucson, AZ 2006-2011 Assistant Professor, Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco, CA 2011-present Associate Professor (1 year Accelerated), Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco. 2011-present Director of Neurocognitive Research, Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA

Honors and Awards: 1996-2000 Graduate Fellowship, University of Florence, Italy 2000 Graduated with Distinction, University of Florence, Italy PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page 2001 Postdoctoral Fellowship Award, Department of Pharmacology, University of Florence, Italy 2004 Travel Award, Winter Conference on Brain Research 2006 Special Award for Research and Career, “Vel l’Etrusco”, Castiglion Fiorentino, Arezzo, Italy 2007 UCSF, Academic Senate Committee on Research - Individual Investigator Award: seed funding 2007 UCSF, Research Evaluation and Allocation Committee Award: seed funding 2007 Tuscany Special Award “Young Talents and Magnificent Excellences”, Arezzo, Italy 2008 New Investigator Research Grant, Alzheimer’s Association 2012 UCSF, Department of Radiology and Biomedical Imaging, Seed Grant Other Experience and Professional Memberships: 2008-present Grant reviewer, Alzheimer’s Association, International Research Grant Program 2008-present Grant reviewer, Canada Foundation for Innovation 2008-present Grant reviewer, Ontario Mental Health Foundation 2011-present Grant reviewer, American Federation for Aging Research’s National Scientific Advisory Council 2011-present Grant reviewer, National Science Center, Poland 2011-present Board of Directors, Winter Conference on Brain Research 2011-present Program Committee, Winter Conference on Brain Research 2012-present Fellowship Committee Chair, Winter Conference on Brain Research 2014-present Ad hoc study section member, NIH NDPR Neural Differentiation, Plasticity, and Regeneration

Memberships: Society for Neuroscience (2002-present), Radiation Research Society (2009-present), American Society for Neurochemistry (2009-present), International Society to Advance Alzheimer Research and Treatment (2011-present)

C. Peer-review publications 1. Giovannini MG, Scali C, Prosperi C, Bellucci A, Vannucchi MG, Rosi S, Pepeu G, Casamenti F. β- Amyloid-induced Inflammation and Cholinergic Hypofunction in the Rat Brain in vivo: Involvement of the p38MAPK Pathway (2002) Neurobiology of Disease. 11: 257-274. 2. Wenk GL, Rosi S, MC Gann K and Hauss-Wegrzyniak B. An NO-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat (2002) European Journal of Pharmacology. 453: 319-324. 3. Rosi S, McGann K, Hauss-Wegrzyniak B and Wenk GL. Potential Role of A2b receptor in the reduction of microglial activation pathway in an Alzheimer’s disease model (2003) Journal of Neurochemistry. 86: 220- 226. 4. Wenk GL, McGann K, Hauss-Wegrzyniak B and Rosi S. The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: Implications for Alzheimer’s disease (2003) Neuroscience.121: 719-129. 5. Wenk GL, McGann K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparrini L, and Ongini E. Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivate of the antioxidant ferulic acid (2004) Journal of Neurochemistry. 89: 484-493. 6. Rosi S, Giovannini MG, Lastage PJ, Munoz C, Pepeu G. S-18986-1, a positive modulator of AMPA receptors with cognition-enhancing properties, increases Ach release in the hippocampus of young and aged rat (2004) Neuroscience Letters. 361: 120-3. 7. Rosi S, Ramirez-Amaya V, Hauss-Wegrzyniak B, Wenk GL. Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors (2004) Journal of Neuroinflammation. 1(1):12-18. 8. Rosi S, Ramirez-Amaya V, Vazdarjanova A, Worley PF, Barnes CA, Wenk GL. Neuroinflammation alters the pattern of behaviorally induced Arc in the hippocampus (2005) Journal of Neuroscience. 25(3): 723- 731. 9. Ramirez-Amaya V, Vazdarjanova A, Mikael D, Rosi S, Worley PF, Barnes CA. Coordinate Arc mRNA and protein expression in the neuronal networks activated by spatial exploration (2005) Journal of Neuroscience. 25(7): 1761-1768. 10. Rosi S, Pert CB, McGann-Gramling and Wenk GL. CCR5 Chemokine Receptor Antagonist regulates microglia and astrocytes activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's

PHS 398/2590 (Rev. 06/09) Page 2 Continuation Format Page disease (2005) Neuroscience. 134 (2):671-6. 11. Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer T, Rosi S, Mikhael D, Worley PF, Guzowski JF, Barnes CA. Behavior induces Arc a plasticity-related immediate-early gene in the principal excitatory and inhibitory CAMKII-positive neurons (2006) The Journal of Comparative Neurology. 498 (3): 317-29. 12. Rosi S, Vazdarjanova A, Ramirez-Amaya V, Worley PF, Barnes CA, Wenk GL. Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression (2006) Neuroscience. 142(4):1303-15. 13. Marchalant Y, Rosi S, Wenk GL. Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a neuroinflammation rat model of Alzheimer disease (2007) Neuroscience. 144(4):1516-22. [PMCID: PMC1852513] 14. Rola R, Zou Y, Huang TT, Fishman K, Baure K, Rosi S, Milliken H, Limoli CL, Fike JR. Lack of EC-SOD in the Microenvironment Impacts Radiation-Induced Changes in Neurogenesis (2007) Free Radicals in Biology & Medicine. 42(8):1133-45. [PMCID: PMC1934512] 15. Andres-Mach M, Rosi S, Rola R, Nalin G, Fike JR. Radiation Effects on Neurogenic Regions in the Mammalian Forebrain (2008) Future Neurology. 2(6):647-659. 16. Rola R, Fishman K, Baure J, Rosi S, Lamborn KR, Obenaus A, Nelson GA, Fike JR. Cranial irradiation with 56Fe reduced hippocampal neurogenesis (2008) Radiation Research 169(6):626-32. [PMCID: PMC2583781] 17. Rosi S, Andres-Mach M, Fishman K, Ferguson R, Levy W, Fike JR. Cranial irradiation alters the behaviorally-induced immediate early gene Arc (activity-regulated cytoskeleton-associated protein) (2008) Cancer Research, Dec 1; 68 (23):9763-70. [PMCID: PMC2597278] 18. Fike JR, Rosi S, Limoli CL. Neural precursor cells and CNS radiation sensitivity (2009) Semin Radiat Oncol. Apr; 19(2):122-32. [PMCID: PMC2683587] 19. Rosi S, Ramirez-Amaya V, Vazdarjanova A, Esperanza EE, Larkin P, Fike JR, Wenk GL, Barnes CA. Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine (2009) Brain; 132:2464-77. [PMCID: PMC2732266] 20. Rosi S, Belarbi K, Ferguson RA, Fishman K, Obenaus A, Raber J, Fike JR. Trauma induced alterations in cognition and expression of the behaviorally-induced immediate early gene Arc are reduced by a previous exposure to 56Fe. Hippocampus:. 2012 Mar;22(3):544-54. doi: 10.1002/hipo.20920. Epub 2010 Dec 29. 21. Rosi S. (2011) Neuroinflammation and the plasticity-related immediate-early gene Arc. Brain Behavior and Immunity: (25): S39-49. [NIHMS273755] 22. Acharya MM , Christie LA, Lan ML, Giedzinski E, Rosi S, Limoli CL. Transplantation of human neural stem cells ameliorates radiation-induced cognitive dysfunction. Cancer Res. 2011 Jul 15;71(14):4834-45. Epub 2011 Jul 14. 23. Raber J, Rosi S, Chakraborti A, Fishman K, Dayger C, Davis M, Villasana L, Fike JR. Effects of 56Fe cranial radiation on hippocampus-dependent cognition and Arc protein expression in the dentate gyrus depend on the salience of the environmental stimuli. Radiat Res. 2011 Aug 8. [Epub ahead of print] 24. Belarbi K, Arellano C, Ferguson R, Jopson T, Rosi S. Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. Brain Behav Immun. 2012 Jan;26(1):18-23. Epub 2011 Jul 20. 25. Rosi S, Ferguson R, Fishman K, Raber J, Fike RJ. The polyamine inhibitor α-Difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. PlosOne 2012;7(1):e31094. Epub 2012 Jan 27. 26. Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S. TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation. 2012 Jan 25;9:23. 27. Tweedie D, Ferguson RA, Fishman K, Frankola KA, van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, Barlati S, Ray B, Lahiri DK, Bosetti F, Greig NH and Rosi S. Tumor necrosis factor- α synthesis inhibitor 3,6’-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease J Neuroinflammation. 2012 May 29;9(1):106. [Epub ahead of print] 28. Chakraborti A, Antino A, Barrett A, Rosi S, Fike JR.Cranial Irradiation Alters Dendritic Spine Density and Morphology in the Hippocampus. PlosOne, 2012;7(7):e40844. Epub 2012 Jul 16. 29. Belarbi K, Jopson T, Arellano C, Rosi S. CCR2 deficiency prevents neuronal dysfunction and cognitive PHS 398/2590 (Rev. 06/09) Page 3 Continuation Format Page impairments induced by cranial irradiation. Cancer Research, 2013 Feb 1;73(3):1201-10. doi: 10.1158/0008-5472.CAN-12-2989. Epub 2012 Dec 13. 30. Ramirez-Amaya V, Argulo P, Chawla M, Barnes C, Rosi S. Sustained transcription of the immediate early gene Arc in the dentate gyrus after spatial exploration. Journal of Neuroscience, 2013 Jan 23;33(4):1631- 1639. 31. Raber J, Allen A, Rosi S, Dayger A, Davis MJ, Fike JR. Effects of whole body 56Fe radiation on fear conditioning and Arc-positive cells in the dentate gyrus. Behav Brain Res. 2013 Feb 28. doi:pii: S0166- 4328(13)00096-X. 10.1016/j.bbr.2013.02.022. [Epub ahead of print] 32. Raber J, Allen A, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR. The effects of 56Fe radiation on hippocampal function are modulated in mice deficient in chemokine receptor 2 (CCR2). Behav Brain Res. 2013 Mar 13. doi:pii: S0166-4328(13)00136-8. 10.1016/j.bbr.2013.03.003. [Epub ahead of print] 33. Allen A, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2 (CCR2). Radiation Research, 2013 Jun 17. [Epub ahead of print] 34. Chakraborti A, Allen A, Sharma S, Fishman K, Obenaus A, Rosi S, Raber J and Fike JR Effects of 56Fe irradiation and trauma on cognition and Arc expression in mice deficient in chemokine receptor 2. Radiation Environmental Biophysics, under review 35. Allen A, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age. International Journal of Radiation Biology, 2013 Oct 29. [Epub ahead of print] 36. Vlkolinsky R, Rudobeck E, Campbell-Beachler M, Allen AR, Allen B, Rosi S, Nelson GA, Ramachandran S, Turner J, Fike JR, Raber J. 28Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice Radiation Research, in press . 37. Belarbi K, Rosi S. Plasticity of adult-born new neurons in the inflamed hippocampus Frontiers in Cellular Neuroscience, 2013 Sep 6;7:145. 38. Acharya MM#, Rosi S#, Jopson T, Limoli C. Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Stem Cells, under review #equal first author contribution 39. Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Low-dose cranial irradiation alters the brain’s microenvironment and permits CCR2+ macrophage infiltration. Plos One, under final revision 40. Allen A, Eilertson K, Sharma S, Baure J, Allen B, Clark DJ, Rosi S, Raber J, Huang TT, Fike JR. Delayed administration of α-difluoromethylornithine prevents hippocampal dependent cognitive impairment after single and combined injury in mice. Under review D. Research Support Ongoing Research Support

NIH/R01 CA133216-01 Rosi (PI) 06/1/09-05/30/14 Brain irradiation affects neuronal function The goal of this study is to use immediate-early gene imaging and neuroinflammation markers to assess the effects of brain irradiation on neuronal functioning with the long term goal of identifying how the evolution of radiation-induced neuronal deficits.

Alzheimer’s Association IIRG-11-202064 Rosi (PI) 09/01/11-08/30/14 Restoring synaptic plasticity in a rat model of Alzheimer’s disease The goal of this proposal is to determine if TNFα-SI treatment restores the ability of hippocampal networks to properly mediate spatial information processing during the pre-plaque amyloid-associated pathology in a novel rat model of Alzheimer’s disease.

NIH/R21 R21AG042016-01A1 Rosi (PI) 06/01/13-05/31/15 Effects of traumatic brain injury on hippocampal network activity: age difference The proposed studies are aimed to test the long term effect of traumatic brain injury on hippocampal network stability in young and old animals.

PHS 398/2590 (Rev. 06/09) Page 4 Continuation Format Page NASA Rosi (PI) 01/01/14-30/01/18 The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

NASA/NNX13AD60G (Raber) Rosi (Institutional PI) 12/31/12-12/30/15 The relation between cognitive injury, network stability, and epigenetic change following exposure to space radiation. The proposed studies will test the effect of space radiation on hippocampal networks stability.

NASA/NSCOR (Nelson) Rosi (institutional PI) 11/1/09-12/30/14 Charged particle radiation and resultant oxidative stress elicit deleterious functional changes in the Central Nervous System. The goal of this proposal is to study the consequences of charged particle radiation on the central nervous system using in vitro and in vivo models and different markers or oxidative stress.

NIH/R01 (Limoli) Rosi (Co-I) 05/01/11-04/31/16 Rescuing radiation-induced cognitive deficits through cranial transplantation of stem cells. The goal of this proposal is to investigate the translational potential and mechanistic basis underlying the capability of intrahippocampal transplantation of human neural stem cells to restore cognition.

NIH/R01NS038079 (Beattie & Bresnahan) Rosi (Co-I) 08/15/2011-3/31/2016 Mechanisms of secondary injury after SCI The goal of this proposal is to optimize dose and timing of single and combination therapies to maximize six week recovery after unilateral cervical spinal cord injury.

Imaging Seed Grant Rosi (PI) 01/01/13-01/31/13 Department of Radiology and Biomedical Imaging (UCSF) In Vivo Imaging of Inflammation in the CNS After Traumatic Brain Injury Using 19F MRI The goal of this proposal is to characterize in vivo the regional distribution of inflammation after TBI and validate the use of 19F MRI as a possible biomarker for predicting cognitive dysfunction and sub -regional changes after TBI in rats.

Completed Research Support NIRG-08-90589 (PI) 09/01/08-08/30/10 Alzheimer’s Association Altered neuronal-microglia communication impacts neuronal functions Role: PI

Academic Senate Individual Investigator Grant (PI) 01/07-01/08 UCSF, Academic Senate Grant Neuroinflammation and neuronal networks activation involved in learning and memory Role: PI

Research Evaluation and Allocation Committee Award (PI) 06/01/07-05/31/08 UCSF REAC GRANT Mapping neural-circuits associated with learning and memory during chronic neuroinflammation Role: PI

Academic Senate Shared equipment Grant (Co-PI) 03/07-02/08 UCSF, Academic Senate Grant Role: Co-PI

NIH/R01 NS046051-05 (Co-I) 01/01/09-12/30/12 Radiation and oxidative stress: effects on neurogenesis PHS 398/2590 (Rev. 06/09) Page 5 Continuation Format Page Role: Co-I

NIH/R21/R33 AI080531 (Co-I) 7/01/08 – 6/30/13 Combined Effects of Traumatic Brain Injury and Ionizing Irradiation on Cellular and Molecular Determinates of Cognitive Functions. Role: Co-I

NASA/NN X08BA07G (Co-I) 10/1/08-06/30/13 Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus dependent cognition and neurogenesis Role: Co-I

PHS 398/2590 (Rev. 06/09) Page 6 Continuation Format Page BIOGRAPHICAL SKETCH

NAME POSITION TITLE Schumacher, Mark A. Professor eRA COMMONS USER NAME (credential, e.g., agency login) Schumacm EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

University of California, San Diego B.A. 06/79 Biology University of California, San Diego Physiology- Ph.D. 04/87 (Advisors: P. Taylor, T. Friedmann) Pharmacology University of California, San Diego M.D. 06/90 Medicine Cedars-Sinai Medical Center, Los Angeles Internship 06/91 Internal Medicine University of California, San Francisco Residency 06/94 Anesthesia Post-Doc (D. Julius, J. Levine) UCSF 06/95 Pain Research Imperial College London, UK Sabbatical 07/04 Biophysics (N. Franks, M. Maze)

A. Personal Statement

I am a clinician-scientist within the Department of Anesthesia and Perioperative Care, UCSF. In addition to serving as Chief of the Division of Pain Medicine, I serve a broad educational role in the clinical and scientific training domains. This includes being the project manager of the UCSF, NIH Center of Excellence in Pain Education, a member of the Molecular Medicine Training program, a faculty within our own Departmental T32 research-training program and directing my own research laboratory. Being part of the proposed Graduate Program in Rehabilitation Science will be a natural fit given my clinical duties in pain management and overall research emphasis in the regulation of peripheral pain transduction. My research group has forged a challenging path to define what controls the expression of TRPV1 (Capsaicin Receptor) at the transcriptional level and that TRPV1 activation can also be negatively regulated by splice variants. Moreover, because TRPV1 has been shown to play a central role in pain and nociceptive signaling, it is likely that the specialized factors that regulate TRPV1 expression also play a key role in regulating other nociceptive genes. We are currently focused on understanding a family of transcription factors that we believe regulate a nociceptive transcriptome in sensory neurons. This is being investigated through the use of a wide range of techniques integrating nociceptive behavior in mice to molecular genetics and large-scale deep sequencing of genes regulated by transcription factors in sensory neurons. Ongoing investigations have now unveiled a network of nociceptive – related genes that function together to mediate the transition from acute to persistent thermal and mechanical hyperalgesia. We have also recently reported (in press) that the anticancer antibiotic mithramycin- A, inhibits TRPV1 expression in sensory neurons. Taken together, we propose that a class of small molecules that down regulate Sp1-like transcription factors in turn will inhibit transitions from acute to chronic pain. We are confident that this line of investigation will provide stimulating questions for developing graduate students to pursue that will be relevant to the clinically challenges of limiting the progression of painful conditions and to restore function.

B. Positions and Honors Professional Experience: 1989-1990 Post Doc, Pain Research, University of California, San Diego 1990-1991 Internship, Internal Medicine, Cedars-Sinai Medical Center, California 1991-1994 Residency, Anesthesia, University of California, San Francisco, 1993-1994 Chief Resident, Dept. of Anesthesia, Moffitt/Long Hospitals University of California, San Francisco 1994-1995 Fellow, Pain Research, University of California, San Francisco (Julius & Levine laboratories) 1994-1995 Clinical Instructor, Dept. of Anesthesia, Moffitt/Long Hospitals, UCSF 1995 -2001 Assistant Professor in Residence, Dept. of Anesthesia, UCSF 1995 -2001 Assistant Professor in Residence, Dept. of Oral & Maxillofacial Surgery, UCSF 1995 -present Attending Anesthesiologist Dept. of Anesthesia and Perioperative Care, UCSF 2001-2003 Associate Professor in Residence, Department of Anesthesia, UCSF 2001-2003 Associate Professor in Residence, Dept. of Oral & Maxillofacial Surgery, UCSF 2003-2012 Associate Professor, Department of Anesthesia, UCSF 2003-2012 Associate Professor, Dept. of Oral & Maxillofacial Surgery, UCSF 2003-2004 Visiting Reader, Dept. of Anaesthetics and Intensive Care, Imperial College London, UK 2010-present Chief, Division of Pain Medicine, Dept. of Anesthesia and Perioperative Care, UCSF 2010-present Medical Director Pain Services, UCSF Medical Center 2013-present Professor - Department of Anesthesia, UCSF 2013-present Professor - Dept. of Oral & Maxillofacial Surgery, UCSF

Honors: 1997-1999 Radiometer/John Severinghaus Fellow in Anesthesia Research, Dept. of Anesthesia, UCSF 1998 - 2000 Foundation for Anesthesia Education Research, New Investigator Award 2000 Sessler Family Anesthesia Research Award, UCSF 2001 International Anesthesia Research Society (IARS), Frontiers in Anesthesia Research Award

Patents: Application: UCSF-435WO, “Methods and Compositions for the Treatment of Pain”

C. Selected Peer-reviewed Publications

Most relevant to the current application 1. Xue Q, Jong B, Chen T and Schumacher MA: “Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by Nerve Growth Factor” J Neurochem. 101: 212-22, 2007 2. Schumacher MA and Eilers H: “TRPV1 splice variants: structure and function” Front Biosci. 15, 872-882, 2010. 3. Eilers, H., Cattaruzza, F., Chu, C., Nassini, R., Materazzi, S., Andre, E., Chu C, Cottrell GS, Schumacher,M.A., Geppetti, P., Bunnett, N.W. Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction” Anesthesiology 112, 1452-1463, 2010. 4. Chu, C., Zavala, K., Fahimi, A., Lee, J., Xue, Q., Eilers, H. and Schumacher, M.A. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons Mol Pain. Jun 6;7:44, 2011. 5. Zavala, K., Lee, J., Chong, J., Sharma. M., Eilers, H., and Schumacher, M. The anticancer antibiotic mithramycin-A, inhibits TRPV1 expression in dorsal root ganglion neurons” Neurosci Lett. 2014 (In press - epub). Additional recent publications (in chronological order) – selected (10 of 31) 1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD and Julius D: “The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway”. Nature 389, 816-824, 1997. 2. Schumacher MA, Moff I, Sudanagunta S and Levine JD: “Molecular Cloning of a N-terminal Splice Variant of the Capsaicin Receptor”: J. Biol. Chem. 275, 2756-2762, 2000. 3. Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD: “The Stretch inactivated Channel SIC, a Vanilloid Receptor Variant, is Expressed in Small-diameter Sensory Neurons in the Rat”. Neurosci. Lett. 287, 215-218, 2000. 4. Stander S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D and Steinhoff M: “Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures” Exp Dermatol. 13, 129-139, 2004. 5. Eilers E, Trilk S, Lee S-Y, Xue Q, Jong B, Moff I, Levine J and Schumacher MA: "Isolation of an mRNA Binding Protein Homologue that is expressed in Nociceptors" Eur. J. Neurosci. 20, 2283-2293, 2004. 6. Eilers H, Lee S-Y, Hau CW, Logvinova A and Schumacher MA: “The rat vanilloid receptor splice variant VR.5’sv blocks TRPV1 activation” Neuroreport. 18, 969-73, 2007 7. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP.:“Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.” J Biol Chem. 282, 20977-90, 2007. 8. Zecharia A, Nelson-Carney L, Gent T, Schumacher M, Jurd R, Rudolph U, Brickley S, Maze M and Franks N: “The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor B3N265M knock-in mouse” J Neurosci. 29, 2177-87, 2009. 9. Schumacher, M.A.: “Transient receptor potential channels in pain and inflammation: therapeutic opportunities” Pain Pract. 10,185-200, 2010. 10. Schumacher M.A. Back Pain and the Mineralocorticoid Receptor: Is There a Connection? Anesthesiology 117, 951-2, 2012.

D. Research Support

Ongoing Research Support NIH R01 NS38737-11 Schumacher (PI) 7/2009 – 6/2013 Capsaicin Receptor Subtypes in Pain Transduction Investigate the regulation of the rTRPV1 gene by Sp1-like transcription factors; determine the physiologic role of TRPV1 splice variants in nociceptive neurons. Role: PI

NIH (CoEPE) Center of Excellence in Pain Education Schumacher (PI) 5/2012 – 8/2014 NIH Pain Consortium Initiative; Develop pain management training resources for health care professionals to advance the assessment, diagnosis, and treatment of pain across all four health professional schools at UCSF. Role: PI – Project Manager (salary support effort = 6%)

NIH T32 GM08440 Young (PI) 7/2012 – 6/2017 Basic Science Anesthesia Research Training Grant Provide oversight and research training opportunities in the area of peripheral pain transduction. Role: Faculty, Mentor; Pain and Addiction Program Administrator

Pending Funding R01 NS38737-08 (Principal Investigator) 2014-2018 Capsaicin Receptor subtypes in Pain Transduction

Completed Research Support

NIH R01 DK046285-09 Kirkwood (PI) 7/2008 – 6/2013 Neural Regulation of Pancreatic Function Investigate the role of nociceptive channels TRPV1, TRPA1 and the PAR 2 receptor in inflammatory pancreatitis. Role: Co-investigator

NIH 3R01NS038737-09S1 Schumacher (PI) 7/2010 – 6/2011 Supplement: Optogenetics Utilize TRPV1 promoter elements to direct expression of light-triggered inhibitory chloride channels in nociceptive neurons. Role: PI

Office of Naval Research/UCSD Schumacher (PI) 7/2010 – 6/2011 Pain Management by an Endogenous Antihyperalgesic Subcontract to determine if halogenated amino acids function as activators / inhibitors of TRPV1 and/or TRPA1. Role: PI

National Headache Foundation Schumacher (PI) 2008-2009 Research Grant Role: PI

UCSF Springer H. Mem. Foundation 2007-2008 Capsaicin Receptor Subtypes in Pain Transduction Role: PI

FAER 2008 summer Medical Student Anesthesia research Fellowship Student Stipend Role: Mentor

NIH T32 - PACCTR 2006-2007 Fellow’s salary Pathways to Careers in Clinical and Translational Research Role: Co-mentor

IARS Frontiers in Anesthesia Research Award 2001-2006 Stretch-Inactivated Channels in Pain Transduction Role: PI

Program Director/Principal Investigator (Smoot, Betty Jeanne): BIOGRAPHICAL SKETCH

NAME POSITION TITLE Betty Smoot Assistant Professor, Dept. of Physical Therapy & eRA COMMONS USER NAME (credential, e.g., agency login) Rehabilitation Science and Dept. of Anatomy BSMOOT EDUCATION/TRAINING DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) San Francisco State University BA 05/81 Biology University of California, San Francisco Post-Bacc. Certificate 09/83 Physical Therapy University of California, San Francisco DPTSc 06/09 Physical Therapy Science American College of Sports Medicine Certification 09/08 Cancer Exercise Trainer Norton School of Lymphatic Therapy Certification 10/10 Lymphedema Therapist

A. Personal Statement

My research encompasses two related areas: 1) Assessment and treatment of physical impairments that result from breast cancer treatment and 2) clinical diagnosis of breast cancer-related lymphedema. I am co- investigator on the Breast Symptoms Study (Miaskowski, PI), a prospective, longitudinal study to evaluate neuropathic pain and lymphedema following breast cancer surgery. This dataset includes a variety of lymphedema and other upper extremity outcomes in a longitudinal dataset that evaluated women prior to, during, and following breast cancer treatment. In 2013, I was awarded a UCSF- Kaiser/DOR Building Interdisciplinary Research Careers in Women’s Health Program (BIRCWH) K12 mentored career award. I am enrolled in the UCSF Master's of Advanced Studies in Clinical Research program and will learn the methods necessary to analyze the longitudinal data from the Breast Symptoms Study to answer the Specific Aims of my BIRCWH proposal. I will identify subgroups of women based on volume changes over time and analyze predictors of group membership. In addition, I will evaluate the ability of bioimpedance to detect early limb volume changes, and evaluate other treatment-related upper extremity impairments. Analysis from the Breast Symptoms Study also includes evaluation for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema following breast cancer treatment. This will provide me with additional research training and expertise. My 2 to 3-year research goal is to transition from the BIRCWH K12 to a NIH NCI K23 or K07 to continue my mentored career development to conduct a pilot study on implementation of risk stratified screening in women at risk for lymphedema after breast cancer treatment, informed by the results of the analysis proposed during the BIRCWH award period. My 5-7 year goal is to become an independent investigator in the field of diagnosis and management of cancer-related LE, and to expose graduate physical therapy students to oncology rehabilitation research.

As part of their doctoral training the Doctor of Physical Therapy (DPT) students participate in research. From 2007-2009, I mentored 3 students in data collection and data analysis. The students prepared and presented the results from a small observational study at the Graduate Research Day at San Francisco State University. From 2011-2012, I mentored 2 DPT students in 2 research projects, one of which resulted in a publication in a peer-reviewed journal. I currently supervise 2 DPT students in their research requirement, which includes participation in data collection, data analysis, and CHR document preparation. I am the course director for PT 251, Research Design, in which students have the opportunity to develop a research question, and become skilled at critical appraisal of published literature. I am also faculty/reader in PT 209/910, Evidence Based Practice, and encourage students to submit abstracts for regional and national conferences, as well as to follow their manuscripts through to publication. Additionally, I am advisor for 10 DPT students. We schedule meetings quarterly on a formal basis; and meet more often as need arises.

OMB No. 0925-0001/0002 (Rev. 8/12 Approved Through 8/31/2015) Page Biographical Sketch Format Page Program Director/Principal Investigator (Smoot, Betty Jeanne): B. Positions and Honors PRINCIPLE POSITIONS 1983 – 1985 Ralph K. Davies Medical Center, San Francisco, CA, Physical Therapist 1985 – 1986 Sonoma Physical Therapy Center, Sonoma, CA, Lead Physical Therapist 1986 – 1987 Readicare Industrial Medicine Clinic, Burlingame/Emeryville, CA; Lead Physical Therapist 1987 – 1988 METS/ Kentfield Hospital, Kentfield CA, Physical Therapist 1988 – 2010 Sonoma Valley Hospital, Sonoma, CA, Lead Physical Therapist 2009 – 2010 University of California, San Francisco, San Francisco, CA, Dept. of Physical Therapy and Rehabilitation Science, Instructor 2010 – present University of California, San Francisco, San Francisco, CA, Dept. of Physical Therapy and Rehabilitation Science, Assistant Adjunct Professor (Primary Appointment) 2010 – present University of California, San Francisco, San Francisco, CA Dept. of Anatomy, Assistant Adjunct Professor (Secondary Appointment)

OTHER POSITIONS HELD CONCURENTLY 2007 – 2008 Sonoma State University, Dept of Kinesiology, Lecturer 2008 – 2008 University of California, San Francisco, Dept. of Physical Therapy and Rehabilitation Science, Teaching Assistant 2006 – 2009 University of California, San Francisco, Dept. of Physiological Nursing, Research Assistant 2008 – 2009 University of California, San Francisco, Dept. of Anatomy, Teaching Assistant 2009 – 2009 University of California, San Francisco, Dept. of Physical Therapy and Rehabilitation Science, Visiting Asst. Professor 2009 – 2010 San Francisco State University, Graduate Program in Physical Therapy, Lecturer 2010 – present San Francisco State University, Graduate Program in Physical Therapy, Asst. Professor Physical Therapy (Volunteer appointment)

HONORS AND AWARDS 2006 Burditt Memorial Mathematics Scholarship, Napa Valley College 2006 Kean Graduate Fellowship Award, University of California, San Francisco 2008 University of California, San Francisco Graduate Student Research Award 2008 California Physical Therapy Association Research Award 2009 UCSF Graduate Division-Earle C. Anthony Travel Award 2009 Graduate Student Distinguished Achievement Award, San Francisco State University 2010 Norton School of Lymphedema, Medi Certified Lymphedema Therapist Scholarship 2010 American Association of Anatomist Training Program Scholarship 2011 California Physical Therapy Association Research Publication Award 2011 Nominee, Outstanding Faculty Mentorship Award, UCSF Graduate Student's Association 2012 Haile T. Debas Academy of Medical Educators Excellence in Teaching Award 2012 Nominee, Distinction in Teaching Award, Under 5 years category; UCSF Academic Senate 2012 Nominee, Outstanding Faculty Mentorship Award, UCSF Graduate Student’s Association 2012 Nominee, Kaiser Award for Excellent in Teaching 2013 Essential Core Teaching Award Commitment to Teaching 2013 UCSF-Kaiser Building Interdisciplinary Research Careers in Women’s Health Scholar

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Smoot, Betty Jeanne): C. Selected Peer-reviewed Publications 1. Smoot BJ, Wampler MA, Topp KS. Breast cancer treatment and complications. Rehabilitation Oncology. 2009; 27:16-26. PMCID: NA 2. Smoot B, Wong J, Cooper B, Wanek L, Topp K, Byl N, Dodd M. Upper extremity impairments in women with or without lymphedema following breast cancer treatment. J Cancer Surviv. 2010 Jun; 4(2):167-78. PMCID: PMC2882040 3. Smoot BJ, Wong JF, Dodd MJ. Comparison of diagnostic accuracy of clinical measures of breast cancer- related lymphedema: area under the curve. Arch Phys Med Rehabil. 2011 Apr; 92(4):603-10. PMCID: PMC3698223 4. Smoot B, Johnson M, Duda J, Krasnoff J, Dodd M. . Cardiorespiratory fitness in women with and without lymphedema following breast cancer treatment. Cancer and Clinical Oncology. 2012; (1):21-31. PMCID: PMC3778372 5. Miaskowski C, Dodd M, Paul SM, West C, Hamolsky D, Abrams G, Cooper BA, Elboim C, Neuhaus J, Schmidt BL, Smoot B, Aouizerat BE. Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery. PLoS One. 2013; 8(4):e60164. PMCID: PMC3629060 6. Smoot BJ, Boyd BS, Byl NN, Dodd MJ. Upper extremity mechanosensitivity following breast cancer treatment. J of Hand Ther. J Hand Ther. 2013 Sep 28. pii: S0894-1130(13)00124-5. doi: 10.1016/j.jht.2013.08.021. [Epub ahead of print]. PMCID in process. 7. Rennke S, Mackin L, Wallhagen M, Tam E, Jue V, Smoot B, Lai C. GeriWard: An Interprofessional Curriculum for Health Professions Student Teams on Systems-Based Care of the Hospitalized Older Adult. MedEdPORTAL; 2013. Available from: www.mededportal.org/publication/9533 8. Leung G, Baggot C, West C, Elboim C, Paul S, Cooper B, Abrams G, Dhruva A, Schmidt B, Kober D, Merriman J, Leutwyler J, Neuhaus J, Langford D, Smoot B, Aouizerat B, Miaskowski C. Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery. Lymphatic Research and Biology. Accepted July 2013. 9. Smoot B, Paul SM, Aouizerat BE, Elboim C, Levine JD, Abrams G, Hamolsky D, Neuhaus J, Schmidt B, West C, Topp K, Miaskowski C. Side of Cancer Does Not Influence Limb Volumes in Women Prior to Breast Cancer Surgery. Lymph Res Biol. Accepted Nov 2013. 10. Chu J, Smoot B, Pawlowsky S, Allen D. Peripheral Response to Cervical or Thoracic Spinal Manual Therapy: An Evidence-Based Review with Meta Analysis. J Man Manip Ther. Accepted December 2013.

SELECTED ABSTRACTS 1. Smoot BJ, Wong J, Cho M, Dodd M, Byl N. The Effect of Breast Cancer Related Lymphedema on Arm Function. 1) Combined Sections Meeting APTA, Las Vegas, NV, February 2009. 2) Western Institute of Nursing Research Conference, Salt Lake City, UT, April 2009 2. Smoot BJ, Butler B, Havard R, Kitano K, Miller L, Topp KS. Interlimb differences in arm function, neurodynamics, and volume in 25 healthy adult women. California Chapter APTA, Annual Meeting, San Diego, CA, October 2009 3. Smoot BJ, Wong J, Dodd MJ, Byl N. Arm function in women with and without breast cancer related lymphedema. California Chapter APTA, Annual Meeting, San Diego, CA, Oct 2009 4. Smoot BJ, Wong J, Dodd MJ. Comparison of clinical measures of breast cancer-related lymphedema using receiver operator characteristic curves. California Chapter APTA Annual Meeting, Oakland, CA, October 2010. 5. Smoot B, Aouizerat B, Topp K, Miaskowski C. Upper limb volume asymmetries in women prior to breast cancer treatment. Annual BIRCWH Scholars Meeting. Washington DC. October 2013. 6. Smoot B, Boyd B, Byl N, Dodd M. Mechanosensitivity in the Upper Limb Following Breast Cancer Treatment. Annual BIRCWH Scholars Meeting. Washington DC. October 2013; APTA Combined Sections Meeting; February 2014. Las Vegas, NV.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Smoot, Betty Jeanne): 7. Lee J, Smoot B, Irwin C, Peled A, Dhruva A, Chesney M, Serrurier K, Sbitany H. The effects of Ashtanga Yoga on arm volume, strength, and range of motion in women at risk for breast cancer-related lymphedema. APTA Combined Sections Meeting; February 2014. Las Vegas, NV. Podium presentation

D. Research Support Ongoing Research Support

K12HD052163 (Scholar) 05/01/2013 - 05/31/2015 NICHD/NIH UCSF-Kaiser/DOR Building Interdisciplinary Research Careers in Women’s Health Program (BIRCWH

R01CA151692 Miaskowski (PI) 09/09/2011 - 08/31/2016 NIH Characterization of and Treatment for Chemotherapy Neuropathy (CIN) In Part 1 of this study, patients who have finished chemotherapy and did or did not develop CIN will be evaluated to determine why some patients do and other patients do not develop CIN. Part 2 of this study will test the effects of a new treatment called photon stimulation (also called infrared light therapy) compared to placebo treatment to improve sensations in the feet of oncology patients with CIN. Role: Co-investigator

R01 CA118658-04 Miaskowski (PI) 09/01/2006 - 07/31/2011 NIH/NCI Long-Term Arm Morbidity Following Breast Cancer Treatment The aims of this study are to determine the prevalence, severity, and the timing of the lymphedema (LE); determine the prevalence and timing of occurrences of changes in shoulder mobility and grip strength associated with LE; compare differences in anxiety, depressed mood, fatigue, sleep disturbance, functional status, and quality of life (QOL) in women who do and do not develop LE; and determine the factors that predict the development of LE. Role: Other Investigator

UCSF Mount Zion Health Fund Sbitany (PI) 02/19//2013 - 02/01/2016 A Pilot Study of Ashtanga Yoga in Prevention of Breast Cancer-Related Lymphedema The goals of this pilot study are to assess the feasibility of incorporating a yoga program into post-operative care for patients at high risk for BCRL and to collect pilot data regarding the efficacy of this intervention in preventing lymphedema. Role: Other investigator

Completed Research Support University of California San Francisco 09/01/2008 - 07/01/2008 Graduate Student Research Award Interlimb differences in function and fluid volume in upper extremities of healthy adult women

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Richard B. Souza Associate Professor eRA COMMONS USER NAME rbsouza EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Davis B.S. 06/98 Exercise Science University of California, Davis A.T.C. 06/99 Athletic Training Samuel Merritt College, Oakland, CA M.P.T. 02/02 Physical Therapy University of Southern California Ph.D. 05/08 Biokinesiology University of California, San Francisco Post-doc 01/10 Radiology & Biomedical Imaging

A. Professional Qualifications Through a combination of clinical and research experiences, I have the expertise to serve as a research mentor in a PhD program in Rehabilitation Science here at UCSF. My clinical experiences as a physical therapist allowed me to see first-hand the effects of disability, and the improved quality of life observed during and after rehabilitation. I have extensive research experience in biomechanics based investigations of the lower extremity. I completed a postdoctoral fellowship in Radiology and Biomedical Imaging focusing on quantitative imaging of cartilage and bone in health and disease. I am currently an Associate Professor with joint appointments in the Departments of Physical Therapy and Rehabilitation Science, Radiology and Biomedical Imaging, and Orthopaedic Surgery. This unique appointment positions me ideally to use cutting edge quantitative imaging to investigate orthopaedic pathology. Over the past 10 years, I have performed numerous studies investigating the influence knee joint contact mechanics on cartilage and bone health, and am proficient in the acquisition, processing and interpretation of kinematic and quantitative MRI of cartilage and bone. In summary, I am ideally suited to serve as a PhD adviser and mentor for students interested in a PhD in Rehabilitation Science with specific focus on Musculoskeletal Biomechanics.

B. Positions and Honors

Positions and Employment 2002-2003 Staff Physical Therapist, Physiotherapy Associates, Kentfield, CA 2002-2003 Per Diem Physical Therapist Care Center of Rossmoor, Walnut Creek, CA. 2003-2008 Teaching/Research Assistant, Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA. 2008-2009 Post-doctoral Scholar, Musculoskeletal Quantitative Imaging Research laboratory, Department of Radiology & Biomedical Imaging, University of California, San Francisco. 2008-2009 Assistant Clinical Professor, University of California, San Francisco, Department of Physical Therapy and Rehabilitation Sciences. 2010- Assistant Professor, University of California, San Francisco, Department of Physical Therapy and Rehabilitation Sciences.

Honors 2001 Physical Therapists Professional Education Scholarship; California Physical Therapy Association 2002 Outstanding Student Award, Samuel Merritt College, Department of Physical Therapy 2005 Outstanding Presentation Award, Southern California Conference of Biomechanics 2006 Jacqueline Perry Scholarship Award – USC, Dept of Biokinesiology and Physical Therapy 2006 Outstanding Mentorship Award – USC, Dept of Biokinesiology and Physical Therapy

2007 Promotion of Doctoral Students (PODS II) Scholarship - Foundation for Physical Therapy 2007 University of Southern California Outstanding Teaching Award 2008 Student Research Award - American College of Sports Medicine, Biomechanics Interest Group 2008 The Dean’s Research Award – Best overall outstanding presentation at USC Research Day 2009 Student Research Publication Award; California Physical Therapy Association 2010 Outstanding Poster Award; California Physical Therapy Association Annual Meeting 2010 NIH/NIAMS P30 American Recovery and Reinvestment Act Faculty Hire 2011 Faculty Publication Award; California Physical Therapy Association

Memberships of Professional Societies 1997-present National Athletic Training Association member 1999-present American Physical Therapy Association member 2001-present American College of Sports Medicine member 2008-present Orthopaedic Research Society member 2008-present International Society for Magnetic Resonance in Medicine member

C. Peer-reviewed Publications

1. Souza RB, Powers CM. Musculoskeletal Imaging: Trochlear Groove Spur in a Patient with Patellofemoral Pain. J Orthop Sports Phys Ther. 2008; 38: 158. 2. Farrokhi SS, Pollard C, Souza RB, Chen Y, Reischl S, Powers CM. Trunk Position Influences Lower Extremity Demands during a Forward Lunge Exercise. J Orthop Sports Phys Ther. 2008; 38:403-9. 3. Austin AB, Souza RB, Meyer JL, Powers CM. Identification of Abnormal Hip Motion Associated with Acetabular Labral Pathology: A Resident's Case Problem. J Orthop Sports Phys Ther. 2008; 38:558- 65. 4. Souza RB, Powers CM. Predictors of Hip Internal Rotation during Running: An Evaluation of Hip Strength and Femoral Morphology in Females with and without Patellofemoral Pain. Am J Sports Med. 2009; 37: 579-87. 5. Souza RB, Powers CM. Hip Kinematics and Patellofemoral Pain: A Comparison of Females with and without Symptoms. J Orthop Sports Phys Ther. 2009;39:12-19. 6. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev E, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues Solan X, Mellivosky L, Pena M, Ferrer O, Matthews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Perez A, Alliston T, Weaver V, Lotz J. A Handheld Instrument for Quantifying Mechanical Properties of Tissues. Rev Sci Instrum. 2009; 80: 054303. PMCID: PMC2832056. 7. Souza RB, Powers CM. Concurrent Criterion-Related Validity and Reliability of a Clinical Test to Measure Femoral Anteversion. J Orthop Sports Phys Ther. 2009; 39:586-92. 8. Fowler EG, Knutson LM, DeMuth SK, Siebert K, Simms V, Sugi M, Souza RB, Karim R, Azen SP. Pediatric Endurance and Limb Strengthening (PEDALS) for Children with Cerebral Palsy Utilizing Stationary Cycling: A Randomized Controlled Trial. Phys Ther. 2010; 9:1-15. 9. Wirth W, Frobell RB, Souza RB, Li X, Wyman BT, Hellio-Le Graverand MP, Link T, Majumdar S, Eckstein F. A Three Dimensional Quantitative Method for Measures of Meniscus Shape, Position, and Signal Intensity Using MRI - Pilot Results in Knee Osteoarthritis. Mag Res Med. 2010; 63:1162-71. 10. Souza RB, Draper CE, Fredericson M, Powers CM. Femoral Rotation and Patellofemoral Joint Alignment: A comparison of females with and without patellofemoral pain using weight-bearing MRI. J Orthop Sports Phys Ther. 2010; 40:277-285. 11. Sorenson SC, Arya S, Souza RB, Pollard CD, Salem GJ, Kulig K. Altered Knee Extensor Dynamics in the Volleyball Approach Jump: The Influence of Patellar Tendinopathy. J Orthop Sports Phys Ther. 2010; 40:568-76. 12. Zarins ZA, Bolbos RI, Pialat JB, Link TM, Li, X, Souza RB, Majumdar S. Cartilage and Meniscus Assessment Using T1rho and T2 Measurements in Healthy Subjects and Patients with Osteoarthritis. Osteoarthritis Cartilage. 2010; 18: 1408-16. 13. Kulig K, Hanigan K, Souza RB, Powers CM. Femoral Torsion Measured by Ultrasound: Test-retest Reliability and Concurrent Validity. Phys Ther. 2010; 90:1-8.

14. Souza RB, Arya S, Pollard CD, Salem G, Kulig K. Patellar Tendinopathy Alters the Distribution of Lower Extremity Joint Effort during Hopping. J Applied Biomech. 2010; 23:249-256. 15. Souza RB, Stehling C, Wyman BT, Le Graverand MP, Li X, Link TM, Majumdar S. The Effects of Acute Loading on T1rho and T2 Relaxation Times of Tibiofemoral Articular Cartilage. Osteoarthritis Cartilage. 2010; 18: 1557-1563. 16. +Souza RB, +Tang SY, Ries M, Hansma PK, Alliston T, Li X. Local Tissue Properties of Human Osteoarthritic Cartilage Correlate with Magnetic Resonance T1rho Relaxation Times. J Orthop Res. 2011; 29: 1312-9. (+ equal contribution first author) 17. Cotofana S, Eckstein F, Wirth W, Souza RB, Li X, Wyman B, Hellio-Le Graverand M-P, Link TM, Majumdar S. In Vivo Measures of Cartilage Deformation Patterns in Healthy and Osteoarthritic Knees using MR Imaging. Eur Radiol. 2011; 6: 1127-35. 18. Hovis K, Haughom BH, Souza RB, Stehling C, Baum T, Nevitt M, McCulloch C, Link TM. Association of Exercise, Strength Training, and Knee-bending Activities with Knee Cartilage T2 Values and WORMS using 3T MRI in Asymptomatic Subjects With and Without Osteoarthritis Risk Factors. Arthritis Rheum. 2011; 63: 2248-56. 19. Baker R, Souza RB, Fredericson M. ITBand Iliotibial Band Syndrome: Soft Tissue and Biomechanical Factors in Evaluation and Treatment Phys Med Rehabil. 2011; 3: 550-61. 20. Haughom B, Schairer W, Souza RB, Carpenter D, Li X, Ma CB. Abnormal Tibiofemoral Kinematics Following ACL Reconstruction Leads to Early Cartilage Degeneration. Knee. 2012; 19: 482-7. 21. Shin CS, Souza RB, Kumar D, Wyman BT, Link TM, Majumdar S. In vivo Tibiofemoral Cartilage-to- cartilage Contact Area of Moderate Osteoarthritis Subjects Under Acute Loading Using MR Imaging. J Magn Res Imaging. 2011; 34: 1405-13. 22. Stehling C, Souza RB, Hellio Le Graverand MP, Wyman BT, Li X, Majumdar S, Link T. Loading of the Knee during 3.0T MRI is Associated with Significantly Increased Medial Meniscus Extrusion in Mild and Moderate Osteoarthritis. Eur J Radiol. 2012; 81:1839-45. 23. Subburaj K, Souza RB, Stehling C, Wyman BT, Le Graverand-Gastineau MP, Link TM, Li X, Majumdar S. Association of MR Relaxation and Cartilage Deformation in Knee Osteoarthritis. J Orthop Res. 2012; 30: 919-26. 24. Haughom B, Souza RB, Schairer W, Hovis K, Feeley B, Li X, Ma CB. Evaluating Rotational Kinematics of the Knee in ACL Ruptured and Healthy Patients. Knee Surg Sports Traumatol Arthrosc. 2012; 20: 663-70. 25. Souza RB, Fang C, Luke A, Wu S, Li X, Majumdar S. Relationship between Knee Net Joint Moments during Jumping Tasks and Knee Articular Cartilage MRI T1rho and T2 Relaxation Times. Clin Biomech. 2012; 27: 403-8. NIHMS 336486. 26. Hovis KK, Alizai H, Tham SC, Souza RB, Nevitt MC, McCulloch CE, Link TM. Non-traumatic anterior cruciate ligament abnormalities and their relationship to osteoarthritis using morphological grading and cartilage T2 relaxation times: data from the Osteoarthritis Initiative (OAI). Skeletal Radiol. 2012; 41:1435-43. 27. Souza RB, Baum T, Wu S, Feeley BT, Kadel N, Li X, Link TM, Majumdar S. Effects of Unloading on Knee Articular Cartilage T1rho and T2 MRI Relaxation Times. J Orthop Sports Phys Ther. 2012; 42: 511-20. 28. Lee SP, Souza RB, Powers CM. The Influence of Hip Abductor Muscle Performance on Dynamic Postural Stability in Females with Patellofemoral Pain. Gait Posture. 2012; 36: 425-9. 29. Subburaj K, Kumar D, Souza RB, Alizai H, Li X, Link TM, Majumdar S. Acute Effect of Running on Knee Articular Cartilage and Meniscus MR Relaxation Times in Young Healthy Adults. Am J Sports Med. 2012; 40: 2134-41. 30. Souza RB, Feeley BT, Zarins ZA, Link TM, Li, X, Majumdar S. T1rho MRI Relaxation in Knee OA Subjects with Varying Sizes of Cartilage Lesions. The Knee. 2013; 20: 113-9. NIHMS 418412. 31. Thuillier D, Souza RB, Wu S, Luke A, Feeley B. T1rho Imaging Demonstrates Early Changes in the Lateral Patella in Patients With Patellofemoral Pain and Maltracking. Am J Sports Med. 2013; 41:1813- 8.

32. Marsh M, Souza RB, Wyman BT, Hellio Le Graverand MP, Karuppasamy S, Link TM, Majumdar S. Differences between X-ray and MRI-determined knee cartilage thickness in weight-bearing and non- weight-bearing conditions. Osteoarthritis Cartilage. 2013; EPub ahead of print. 33. Nardo L, Sandman DN, Virayavanich W, Zhang L, Souza RB, Steinbach L, Guindani M, Link TM. MR Imaging Appearance and Natural Evolution of Disuse Osteopenia. Eur Radiol. 2013; EPub ahead of print. 34. Subburaj K, Souza RB, Wyman BT, Le Graverand-Gastineau MP, Li X, Link TM, Majumdar S. Changes in MR Relaxation Times of the Meniscus with Acute Loading: an in vivo pilot study in knee osteoarthritis. J Magn Res Imaging. 2014; [in press] 35. Kumar D, Subburaj K, Alizai, H, Luke A, Li X, Majumdar S, Link TM, Souza RB. Static and Dynamic Alignment, Functional Loading and Knee Cartilage MR Relaxation Times in Young Adults. [paper in review] J Orthop Res. 36. Li X, Schooler J, Liang F, Shet K, Han E, Chen W, Souza RB, Majumdar S. Simultaneous Acquisition of T1ρ and T2 Quantification in Cartilage - Reproducibility and Diurnal Variation. [paper in review]. 37. Kumar D, Subburaj K, Lin W, Karampinos D, Li X, Link TM, Souza RB, Majumdar S. Thigh Muscle Morphology is Related to Walking Mechanics and Knee Cartilage Relaxation Times in Young Adults. [paper in review]. J Orthop Sports Phys Ther. 38. Kumar D, Wyatt C, Lee S, Nardo L, Link TM, Majumdar S, Souza RB. Association of Cartilage Defects, and other MR Findings with Pain and Function in Individuals with Mild-Moderate Radiographic Hip Osteoarthritis and Controls. J Orthopaedic Res. 2013; 21:1685-1692. 39. Souza RB, Wu S, Morse LJ, Subburaj K, Allen CR, Feeley BT. Cartilage MRI Relaxation Times after Arthroscopic Partial Medial Meniscectomy Reveal Localized Degeneration. [paper in review]. Knee Surg Sports Traumatol Arthrosc.

D. Research Support

Ongoing Research Support

1 R01 AR062370-01 (PI: Souza) 9/1/11-8/31/15 NIH/NIAMS Contact Mechanics, Neuromuscular Control, and Cartilage Composition in Knee OA This project will enable the compilation of a comprehensive database of articular contact mechanics using kinematic-MRI, neuromuscular control during walking, metrics of functional performance, and quantitative MR for cartilage and meniscus composition over 3 years in subjects with and without knee OA. Role: PI

OREF/Goldberg Arthritis Research Grant (Co-PI) 7/1/12-06/30/14 (NCE) Orthopaedic Research & Education Foundation Quantitative MRI Evaluation of Articular Cartilage and Kinematic changes in the knee after Meniscectomy The objective of this project is to evaluate the early changes in cartilage health following partial meniscectomy of the posterior horn of the medial meniscus.

P50 AR060752 (Co-PIs: Majumdar & Lane) 4/1/2011–3/31/2016 NIH/NIAMS Translation of Quantitative Imaging in Osteoarthritis The overall objective of this proposal is to integrate cutting edge, quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. Role: Co-investigator, Project Co-PI, Core Director

2 R01 AR046905-11 (PI: Majumdar) 6/1/2011-5/31/2016 NIH/ NIAMS Loaded and Unloaded MR Imaging of Meniscus-Cartilage-Trabecular Bone in OA

The goal of this study is to determine the predictive capability of cartilage biomechanics, assessed though loaded MRI, of determining disease onset and progression in persons with and without knee osteoarthritis. Role: Co-investigator

Radiology Seed Grant #13-23 (PI: Souza) 09/10/2013 - 09/09/2014 UCSF Department of Radiology and Biomedical Imaging Gait Retraining to Reduce Progression of Knee OA The goal of this seed grant is to determine the effects gait retraining on cartilage composition, muscle and joint morphology, pain, function, and kinematics and kinetics during functional tasks in persons with symptomatic knee OA.

Completed Support (past 2 years)

Mobile Health Research Grant (PI: S Roy) 3/1/12-2/28/13 UCSF Resource Allocation Program (RAP) Universal Bluetooth 4.0 Module and Data Transfer Protocol Framework for Clinical Device Studies The goal of this project is to use Bluetooth technology to optimize data transfer to secure networks for devices such as the wireless Physical Activity Monitor (wi-PAM) and others. Role: Co-investigator

Strategic Opportunity Support - Shared Equipment Grant Souza – (PI: Souza) 1/1/2011-6/30/2012 Center for Translational Science Institute (CTSI) - University of California, San Francisco Bringing Muscle Performance Assessment to UCSF’s Mission Bay Campus The goal of this project is to equip the UCSF Mission Bay campus with the latest technology in muscle performance assessment through multi-modal dynamometry. Through isometric, isokinetic, and isotonic testing, comprehensive muscle performance testing is now a reality at UCSF's Mission Bay campus. Role: PI

REAC Award (PI: Souza) 6/1/2010-5/31/2012 University of California, San Francisco Bone and Cartilage Adaptation to Load The goal is to perform a comprehensive analysis of foot and ankle structural properties in three distinct activity populations – long-distance runners, pointe ballet dancers, and sedentary controls. Using HRpqCt to evaluate metatarsal structural properties, and MRI to quantify cartilage composition, this study will determine how different habitual loading strategies influence bone and cartilage structure. Role: PI

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Raymond A. Swanson, M.D Professor and Vice-Chair, Dept. of Neurology, UCSF Chief, Neurology and Rehab. Service, VAMC San Francisco eRA COMMONS USER NAME SWANSON EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Michigan B.S. 1974-1978 Cell Biology University of Michigan M.D. 1978-1982 Medicine Virginia Mason Hospital, Seattle, WA 1982-1983 Internship (Medicine) University of California, San Francisco 1983-1986 Residency (Neurology) University of California, San Francisco 1986-1989 Post-doc (Neuroscience) Stanford University 1989-1990 Post-doc (Neuroscience)

A. Personal Statement I have 25 years experience in clinical neurology and in basic science of neurological disorders. My primary research aim is to identify interventions that can improve outcomes after stroke and other neurological disorders. My work focuses on oxidative stress as a product of both excitoxicity and post-injury inflammation, and I am particularly interested in bioenergetic and metabolic factors that can modulate these factors after injury. I have recently served as PI on a program project-type grant, funded by the Dept. of Veterans Affairs Rehabilitation Research and Development division, evaluating multimodal therapeutic interventions in animal models of CNS injury., I have served as a mentor for 32 post-doctoral fellows, several of whom have established independent funding and laboratories. Time and effort statement: Research 60%; Teaching/mentoring 25%; Administration 15%

B. Positions 01/01/94-06/15/01 Staff Physician and Assistant Chief of Neurology and Rehabilitation, VAMC San Francisco 11/15/00-05/15/01 Visiting Professor, Buck Institute for Age Research, Novato, CA 07/01/02 - present Professor and Vice-Chair, Dept. of Neurology, UCSF 07/01/02- present Chief, Neurology and Rehabilitation Service, VAMC San Francisco Other Positions, Honors, and Professional Memberships 1998 – 2002, 2008 American Heart Association (Stroke) Grant Review Committee 1998 - 2000 Amyotrophic Lateral Sclerosis Association Grant Review Committee 1999 - 2002 NIH BDCN-3 study section 1999 - present Editorial Board, Glia 2001, 2006 NIH Stroke Progress Review Group 2002 - 2010 Handling Editor, Journal of Neurochemistry 2003 - present Board of Directors, Northern California Institute for Research and Education. 2005 Study section chair, “Neurodegeneration, Neuroinflammation, and Mitochondria” (NDBG) 2006- present ad hoc reviewer for Neural Oxidative Metabolism and Death Study Section (NOMD) 2012-present Editorial Board (Associate Reviewer), Journal of Neuroscience Member: American Academy of Neurology, American Neurological Association, Society for Neuroscience, International Society for Neurochemistry, Stroke Council of the American Heart Association, International Society of Cerebral Blood Flow and Metabolism

C. Peer-Reviewed Publications (last 3 years and selected others from 130) 1985 Montiero MLR, Swanson RA, Coppetto JR, Cuneo RA, DeArmond SJ, Prusiner SB A microangiopathic syndrome of encephalopathy hearing loss, and retinal arteriolar occlusions. Neurology 35:1113-1121 1990 Swanson RA, Morton MT, Tsao-Wu G, Savalos R, Davidson C, Sharp FR: A semi-automated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10:290-293 1992 Swanson RA, Morton MT, Sagar SM, Sharp FR: Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography Neuroscience 51:451-461 1993 Swanson RA, Choi DW: Glial glycogen stores affect neuronal survival during glucose deprivation in vitro. J Cereb Blood Flow Metab 13:162-169 1997 Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Longuemare MC: Neuronal regulation of glutamate transporter expression in astrocytes. J Neuroscience 17:932-940 1999 Swanson RA: Intravenous heparin for acute ischemic stroke: What can we learn from the megatrials? Neurology 52:1746-1750 1999 Duan S, Farrell K, Guenza JK, Stein BA, Swanson RA: Glutamate induces a rapid upregulation of astrocyte glutamate transport and redistribution of GLAST. J Neuroscience 19:10193-10200 2001 Ying W, Sevigny MB, Chen Y, Swanson RA: Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc Natl Acad Sci , 98:12227-12232, 2001 2002 Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA: Barbiturates potentiate excitotoxicity by inhibiting mitochondrial respiration. J Neuroscience, 22:9203-9209 2003 Duan S, Anderson CM, Keung E, Farrell K, Chen Y, Chen Y, Swanson RA: ATP induces glutamate release from astrocytes through a P2X7 receptor. J Neuroscience, 23:1320-1328 2003 Garnier P, Ying W, Swanson RA : Ischemic preconditioning by caspase cleavage of Poly(ADP-ribose) polymerase-1. J Neuroscience 23:7967-7973 2003 Suh SW, Aoyama K, Chen Y, Garnier P Matsumori Y, Gum E, Liu J, Swanson RA: Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J Neuroscience 23:10681-10690 2005 Giffard R, Swanson RA, Ischemia-induced programmed cell death in astrocytes. Glia 21:299-306 2005 Kauppinen TM, Swanson RA: Poly(ADP-ribose)polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9 – mediated neuron death. J Immunology, 15:2288-2296 2006 Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nature Neuroscience 9:119-126 2006 Kauppinen TM, Suh SW, Wiggins AK, Huang EJ, Swanson RA: Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated proteins 1/2 . Proc Natl Acad Sci 103:7136-41 2006 Alano CC, Kauppinnen TM, Swanson RA: Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci 103:9685-90 2007 Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA: Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest 117:910-8. 2008 Kauppinen TM, Higashi, Y, Suh SW, Escartin C, Nagasawa K, Swanson RA: Zinc triggers microglial activation. J Neuroscience 28:5827-35 2008 Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA: Glucose and NADPH oxidase drive neuronal superoxide production during ischemia-reperfusion. Annals of Neurology 64:654–663 2009 Kauppinen TM, Suh SW, Hamby AM, Berman A, Swanson RA: Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury. J Cereb Blood Flow Metab, 29:820-9 2009 Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, Edling Y, Chan PH, Swanson RA: NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nature Neuroscience, 12:857-63, 2009

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page 2010 Alano C, Garnier P, Ying W, Higashi Y, Kauppinen TM, Swanson RA. NAD+ depletion is necessary and sufficient for PARP-1 - mediated neuronal death. J Neuroscience, 30:2967-78 2010 Berman AE, Chan WY, Brennan AM, Adler BL, Swanson RA: N-Acetylcysteine Prevents Loss of Dopaminergic Neurons in the EAAC1-/- Mouse. in press, Annals of Neurology 2010 Won SJ, Yoo BH, Brennan AM, Shin BS, Kauppinen T, Berman A, Swanson RA, Suh SW: EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia., J Neuroscience 30:15409-18 2011 KauppinenTM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid beta. J Neuroinflammation, 8:152 2011 Berman AE, Chan WY, Brennan AM, Adler BL, Swanson RA: N-Acetylcysteine Prevents Loss of Dopaminergic Neurons in the EAAC1-/- Mouse. Annals of Neurology 69:509-20 2011 Escartin E, Won SJ, Malgorn C, Auregan G, Berman AE, Chen P-C, Deglon N, Johnson JA, Suh SW, Swanson RA: Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression. J Neuroscience 31:7392-7401 2011 Won SJ, Tang X, Suh SJ, Yenari MA, Swanson RA: Hyperglycemia promotes tPA-induced hemorrhage by promoting superoxide production. Annals of Neurology 70:583-90, 2011 2012 Won SJ, Choi BY, Ying W, Swanson RA, Suh SW: Prevention of traumatic brain injury-induced neuron death by intranasal delivery of NAD+. J Neurotrauma, 29:1401-9 2012 d’Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa SM, Liu J, Swanson RA: Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation, 9:31-36 2012 Swanson RA: One cell’s poison is another cell’s cure. Nature Neuroscience, 15:505-6 [invited commentary] 2012 Reyes RC, Brennan AM, Shen Y, Baldwin Y, Swanson RA: Activation of neuronal NMDA receptors induces superoxide - mediated oxidative stress in neighboring neurons and astrocytes. J Neurosci, 32:12973-8 2012 WonSJ, Yoo BH, Kauppinen T, Choi BY, Kim JH, Jang BG, Lee MW, Sohn M, Liu J, Swanson RA, Suh SW: Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglia activation and cognitive impairment in diabetic rats. J Neuroinflammation, 9:182-187 2013 Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa SM, Swanson RA, Liu J. Beneficial effects of minocycline and modified constraint physical therapy following experimental TBI. Neurorehabilitation and Neural Repair 9:889-99 2013 Brennan-Minella AM, Shen Y, Swanson RA. Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. Cell Death and Disease, 4:e580 2013 Kauppinen TM, Gan L, Swanson RA: Poly(ADP-ribose) polymerase-1 -induced NAD+ depletion promotes Nuclear Factor-κB transcriptional activity by preventing p65 deacetylation. Biochim Biophys Acta, i833:1985-9 2013 Chen Y, Won SJ, Xu Y, Swanson RA: Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. Curr Med Chem, in press 2013 Brennan-Minella AM, Won SJ, Swanson RA: NADPH oxidase: linking glucose, acidosis, and excitotoxicity in stroke. Antioxidant and Redox Signaling, in press 2013 Min SW, Sohn PD, Cho SH, Swanson RA, Gan L: Sirtuins in neurodegenerative diseases: An update on potential mechanisms. Frontiers in Aging Neuroscience, 5:53-58 2013 Lam TI, Brennan-Minnella AM, Won SJ, Shen Y, Hefner C, Shi Y, Sun D, Swanson RA. Intracellular pH reductions prevent excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase, Proc Natl Acad Sci, 110:E4362-8 2013 Baxter P, Chen Y, Swanson RA: Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke. Translational Stroke Research, in press

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page D. Research Support Current Research support 1) DoD (W81XWH-13-1-0091 09/25/13 – 09/24/16 Mechanistic Links Between PARP, NAD, and Brain Inflammation after TBI Role: PI Aims: To determine whether additive or synergistic effects can be obtained on recovery after injury using physical therapy, a neurotrophin agonist, and an anti-inflammatory agent

2) National Institutes of Health (R01 NS081149) 09/01/12 - 05/31/17 “Regulatory Control of Glutamate-induced Superoxide Production Role: PI Aims: To identify the physiological mechanisms regulating NMDA-induced neuronal superoxide production

3) National Institutes of Health (2R01 NS041421) 07/01/10 - 06/30/15 “PARP and PARG – mediated neuronal death” Role: PI Aims: To elucidate how PARP and PARG influence the inflammatory response in the CNS

4) Department of Veterans Affairs (REAP Award; similar to NIH PPG) 07/01/09 – 06/30/14 Multimodal strategies for improving recovery from brain injury Role: PI Aims: To determine whether additive or synergistic effects can be obtained on recovery after injury using physical therapy, a neurotrophin agonist, and an anti-inflammatory agent

Prior support (last 3 years) National Institutes of Health (R13 NS59367) Role: PI 07/0/11 – 06/30/12 “10th International Conference on Brain Energy Metabolism Bioenergetics of neurological disease and aging” Role: PI National Institutes of Health P50 NS14543- Role: project PI 07/01/07 - 06/30/12 CNS Injury and Research Center Project #2 “Glucose, oxidative stress, and reperfusion hemorrhage” Department of Veterans Affairs (Merit Review Award) Role: PI 07/01/07 – 06/30/11 A novel mouse model of Parkinson’s disease Michael J Fox Research Foundation Role: PI 01/01/10 – 12/31/10 N-acetyl cysteine CSF levels and biomarkers in a mouse model of PD NCIRE (DoD cooperative award) Role: PI 10/01/08 – 09/31/10 Promoting recovery from traumatic brain injury by suppressing Inflammation

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Program Director/Principal Investigator: Topp

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Topp, Kimberly S. Professor eRA COMMONS USER NAME (credential, e.g., agency login) TOPPKIM

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Northern Arizona University, Flagstaff B.S. 06/81 Physical Therapy Anatomy and Cell University of California, Davis Ph.D. 06/90 Biology Postdoctoral University of California, San Francisco 06/94 Neurobiology Fellow

A. Personal Statement In my 20 years at UCSF, have mentored physical therapy students in the MS and DPT professional programs, and doctoral students in the Doctor of Physical Therapy Science (DPTSc) program. I have also guided doctoral students outside of UCSF. I directed Meredith Wampler, a DPTSc student, in an evaluation of the extent of sub-clinical and overt sensorimotor neuropathy in subjects with breast cancer treated with taxanes. Dr. Wampler documented the sensory neuropathy and measured the correlation between severity of neuropathy and quality of life, level of pain, and balance impairments. Another DPTSc student, Betty Smoot, worked in collaboration with Marylin Dodd in the School of Nursing, on a large dataset from the oncology population to quantify lymphedema and its functional consequences in patients treated with surgery and chemotherapy. Dr. Smoot subsequently received funding through a BIRCWH K award, and has been productive in her early faculty position. We continue to collaborate with Dr. Christine Miaskowski in the School of Nursing to extend the studies and better predict who is most likely to develop severe chemotherapy-induced neuropathy. I have a strong interest in peripheral nerve biomechanics, and mentored DPTSc student, Benjamin Boyd, in his studies quantifying nerve motion during limb motion. Lastly, I was a mentor to DPTSc student, Amber Fitzsimmons, in her qualitative and quantitative study of interprofessional experiences in physical therapy clinical clerkships. Dr. Fitzsimmons is continuing her work as a Faculty Lead in Interprofessional Education at UCSF. All four of these DPTSc graduates moved into faculty positions, and continue to publish in their fields. As Department Chair, I oversee our Outpatient Physical Therapy Faculty Practice and our Physical Therapy Health and Wellness Center, which is well equipped for aerobic training. I also direct the anatomy curriculum for the School of Medicine, teach courses in anatomy, nerve biomechanics and medical screening.

B. Positions and Honors Principal Positions Held 1993-1994 University of California, San Francisco Assistant Adjunct Anatomy Professor 1994-2000 University of California, San Francisco Assistant Professor Physical Therapy 2000-2003 University of California, San Francisco Associate Adjunct Anatomy Professor 2003-2006 University of California, San Francisco Associate Professor Anatomy 2000-2006 University of California, San Francisco Associate Professor Physical Therapy 2006-present University of California, San Francisco Professor Physical Therapy 2006-present University of California, San Francisco Professor Anatomy 2007-2009 University of California, San Francisco Interim Chair Physical Therapy 2009-present University of California, San Francisco Chair Physical Therapy PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Topp

Other Positions Held Concurrently 1996-present UCB/UCSF Program in Bioengineering Affiliate Member 2003-present UCSF Discipline leader, Department of Anatomy Anatomy Curriculum, Medical School Essential Core 2009-present UCSF/SFSU Graduate Program in Director, UCSF Physical Therapy

Honors Awards 2000 Faculty Mentorship Award Graduate Student Association and Graduate Division Alumni Association, UCSF 2002 Steven J. Rose Lecturer School of Medicine, Washington University, St. Louis, MO 2004 Outstanding Lecture Series Award School of Medicine, UCSF 2004 Elected member, Academy of Medical Educators Academy of Medical Educators, UCSF 2005 Innovative Teaching Award School of Medicine, UCSF 2006 Henry J. Kaiser Award for Excellence in Teaching School of Medicine, UCSF 2006 Commitment to Teaching Award School of Medicine, UCSF 2006 Outstanding Service Award Academy of Medical Educators, School of Medicine, UCSF 2010 Fellow of the American Association of Anatomists American Association of Anatomists 2010 Essential Core Teaching Award, Class of 2013, School of Medicine, UCSF Outstanding Lecture Series 2011 Essential Core Teaching Award, Class of 2014, School of Medicine, UCSF Outstanding Lecture

Memberships 1981 present American Physical Therapy Association 1990 present Research, Orthopedic, Education, Oncology Sections, American Physical Therapy Association 1981 present California Physical Therapy Association 1985 present American Society for Cell Biology 1990 present Society for Neuroscience 1994 present American Association of Anatomists 2004 present American Association of Clinical Anatomists 2013 present Society of Ultrasound in Medical Education

C. Peer-Reviewed Publications 1. Topp, K.S., Faddis, B.T. and V.K. Vijayan. 1989. Trauma-induced proliferation of astrocytes in the brains of young and aged rats. Glia. 2:201-211. (PMID: 2526082) 2. Topp, K.S., Tablin, F. and J. Levin. 1990. Culture of isolated bovine megakaryocytes on reconstituted basement membrane matrix leads to proplatelet process formation. Blood. 76:912-924. (PMID: 2393717) 3. Topp, K.S., and F. Tablin. 1991. Bovine megakaryocyte integrins: their association with extracellular matrix in vivo, Comp. Haematol. Intl. 1:135-144. 4. Navarro, D., Paz, P., Tugizov, S., Topp, K., LaVail, J., and L. Pereira. 1993. Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology. 197:143-158. (PMID: 7692667) 5. LaVail, J.H., Topp, K.S. and S.R. Carter. 1993. The retrograde tracer Fluoro-Gold affects the infectivity of herpes simplex virus. Brain Res. 625:57-62. (PMID: 8242400) PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: Topp

6. Topp, K.S., Meade, L.B., and J.H. LaVail. 1994. Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J. Neurosci. 14:318-325. (PMID: 8283239) 7. Grimes, M.L., Zhou, J., Beattie, E., Yuen, E.C., Hall, D.E., Valletta, J.S., Topp, K.S., LaVail, J.H., Bunnett, N.W., and W.C. Mobley. 1996. Endocytosis of activated TrkA: evidence that NGF induces formation of signalling endosomes. J. Neurosci. 16:7950-7964. (PMID: 8987823) 8. Topp, K.S., Rothman, A.L., and J.H. LaVail. 1997. Herpes virus infection of RPE and MDCK cells: polarity of infection. Exp. Eye Res. 64:343-354. (PMID: 9196385) 9. LaVail, J.H., Topp, K.S., Giblin, P.A., and J.A. Garner. 1997. Factors that contribute to the efficiency of transneuronal spread of herpes simplex virus. J. Neurosci. Res. 49:485-496. (PMID: 9285524) 10. Byl, N. and K.S. Topp. 1998. Focal hand dystonia: A case report. Phys. Ther. Case Reports. 1:39-52. 11. Tanner, K.D., Levine, J.D., and K.S. Topp. 1998. Microtubule disorientation and axonal swelling in unmyelinated sensory axons during vincristine-induced painful neuropathy in rat. J. Comp. Neurol. 395:481-492. (PMID: 9619501) 12. Topp, K.S., and N.N. Byl. 1998. Movement dysfunction following repetitive hand opening and closing: anatomical analysis for evidence of tissue microtrauma in Owl monkeys. Mov. Disord. 14:295-306. (PMID: 10091624) 13. Topp, K.S., Tanner, K.D., and J.D. Levine. 2000. Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. J. Comp. Neurol. 424:563-576. (PMID: 10931481) 14. Byl, C. Puttlitz, C., Byl, N., Lotz, J., and K. Topp. 2002. Strain in the median and ulnar nerves during upper extremity positioning. J. Hand Surg. 27:1032-1040. (PMID: 12457354) 15. Painter, P.L., Topp, K.S., Krasnoff, J.B., Adey, D., Strasner, A., Tomlanovich, S., and P. Stock. 2003. Health-related fitness and quality of life with steroid minimization following renal transplantation. Kidney Intl. 63:2309-2316. (PMID: 12753323) 16. Painter, P.L., Walcott, S., Krasnoff, J.B., Taylor, J., Adey, D., Tomlanovich, S., Stock, P., and K.S. Topp. 2003. Exercise capacity and muscle structure in kidney recipient and twin donor. Clin. Transplant. 17:225-230. (PMID: 12780672) 17. Topp, K.S., Painter, P.L., Walcott, S., Krasnoff, J.B., Adey, D., Sakkas, G., Taylor, J., McCormick, K., teNyenhuis, M., Iofina, M., Tomlanovich, S., Stock, P. 2003. Alterations in skeletal muscle structure are minimized with steroid withdrawal following renal transplantation. Transplantation. 76:667-673. (PMID: 12973106) 18. Topp, K.S. Prosection versus dissection: the debate continues. 2004. Anat Rec. 281B:12-14. (PMID: 15558780) 19. Wampler, M.A., Hamolsky, D., Hamel, K., Melisko, M., Topp, K.S. Case report: painful peripheral neuropathy following treatment with docetaxel for breast cancer. Clin. J. Oncol. Nurs. 9:189-193, 2005. (PMID: 15853162) 20. Boyd, B., Puttlitz, C., Gan, J., Topp, K.S. Strain and excursion in the rat sciatic nerve in situ during a modified straight leg raise are altered after traumatic nerve injury. J. Orthop. Res. 23:764-770, 2005. (PMID: 16022988) 21. Trivedi, A., Hsu, J-Y.C., Lin, Y., Goussev, S., Gan, J., Topp, K.S., Noble-Haeusslein, L.J. The effects of acute and extended inhibition of matrix metalloproteinases on demyelination and functional recovery after spinal cord injury. Internatl. J. Neuroprotection and Neuroregeneration. 2:30-38, 2005. 22. Topp, K.S., Boyd, B.S. Structure and biomechanics of peripheral nerves: nerve responses to physical stresses and implications for physical therapist practice. Phys. Ther. 86:92-109, 2006. (PMID: 16386065) 23. Chou, C.L., Topp, K.S., O'Sullivan, P. Multidisciplinary teaching of the musculoskeletal physical examination. Med. Educ. 40:481-482, 2006. (PMID: 16635154) 24. Wampler, M.A., Miaskowski, C., Hamel, K., Byl, N., Rugo, H., Topp, K.S. The modified Total Neuropathy Score: a clinically feasible and valid measure of taxane-induced peripheral neuropathy in women with breast cancer. J. Supportive Oncol. 4:397-403, 2006. 25. Boyd, B.S., Puttlitz, C., Noble-Haeusslein, L.J., Constance, C.M., Trivedi, A., Topp, K.S. Deviations in gait pattern in experimental models of hindlimb paresis demonstrated by a novel pressure mapping system. J. Neurosci. Res., 85:2272-2283, 2007. (PMID: 17539027) PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator: Topp

26. Wampler, M.A., Topp, K.S., Miaskowski, C., Byl, N.N., Rugo, H.S., Hamel, K. Quantitative and clinical description of postural instability in women with breast cancer treated with taxane chemotherapy. Arch. Phys. Med. Rehabil. 88:1002-1008, 2007. (PMID: 17678662) 27. Smoot, B.J., Wampler, M.A., Topp, K.S.. Breast cancer treatment and complications. Rehabil. Oncol. 27:16-26, 2009. 28. Zaid, H., Ward, D., Sammann, A., Topp, K., Tendick, F., Maa, J.. Integrating surgical skills education into the anatomy laboratory. J. Surg. Res. 158:36-42. 2010. (PMID: 19159909) 29. Boyd, B.S., Wanek, L., Gray, A., Topp, K.S. Mechanosensitivity of the lower extremity nervous system during straight leg raise neurodynamic testing in healthy individuals. J. Orthop. Sports Phys. Ther. 39:780-790, 2009. (PMID: 19881004) 30. Smoot, B.J., Wong J., Cooper, B., Wanek, L., Topp, K.S., Byl, N.N., Dodd, M.J. Upper extremity impairments in women with or without lymphedema following breast cancer treatment. J Cancer Surviv. 4:167-178, 2010. (PMID: 20373044) 31. Boyd, B.S., Wanek, L., Gray, A.T., Topp, K.S. Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. BMC Neurol. Aug 28;10:75, 2010. (PMID: 20799983) 32. Chou, C.L., Topp, K.S., Kruidering-Hall, M. Integrating surface anatomy learning with clinical skills training. Med. Educ. 44:1127-1128, 2010. (PMID: 20946492) 33. Levine, J.M., Levine, G.J., Porter, B.F., Topp, K., Noble-Haeusslein, L.J. Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J. Neurotrauma. 28:675- 688. 2011. (PMID: 21438715) 34. Topp, K.S. and Boyd, B.S. Peripheral nerve: from the microscopic functional unit of the axon to the biomechanically loaded macroscopic structure. J Hand Ther. 25:142-151, 2012. (PMID:22133662) 35. Wamsley, M.A., Staves, J., Kroon, L., Topp, K.S., Hossaini, M., Newlin, B., Lindsay, C., O’Brien, B. The impact of an interprofessional standardized patient exercise on attitudes toward working in interprofessional teams. J Interprofessional Care 26:28-35. 2012. (PMID: 22233365) 36. Kinder, J., Lee, K., Thompson, H., Hicks, K., Topp, K., Madsen, K.A. Validation of a hip-worn accelerometer in measuring sleep time in children. J Ped. Nursing. 27:127-133. 2012. (PMID:22341191) 37. Chou, C., Promes, S., Souza, K., Topp, K., O'Sullivan, P. Twelve tips for facilitating successful teleconferences. Medical Teacher. 34:445-449, 2012. (PMID:22449266) 38. Boyd, B.S., Gray, A.T., Dilley, A., Wanek, L., Topp, K.S. The pattern of tibial nerve excursion with active ankle dorsiflexion is different in older people with diabetes mellitus. Clin. Biomech. 27:967-971, 2012. (PMID:22809735) 39. Boyd, B.S., Topp, K.S., Coppieters, M.W. Impact of movement sequencing on sciatic and tribial nerve strain and excursion during the straight leg raise test in embalmed cadaver. J. Orthop. Sports Phys. Ther. 43:398-403, 2013. (PMID:23633619) 40. Smoot, B., Miaskowski, C., Aouizerat, B., Topp, K., Hamolsky, B., Abrams, G., Neuhaus, J., Elboim, C., Schmidt, B., Levine, J., Paul, S., West, C. Side of cancer does not influence limb volumnes in women prior to breast cancer surgery. Lymphatic Res. Biol. 2013. 41. Topp, K.S. Nerve Biomechanics. in Gray's Anatomy, 41st Ed. Elsevier Publishers. 2014. (in press) D. Research Support On-going Research Support

R01CA151692 Miaskowski (PI) 09/09/2011 - 08/31/2016 NIH Characterization of and Treatment for Chemotherapy Neuropathy This study will be conducted in two parts. In Part 1, patients who have finished chemotherapy and did or did not develop CIN will be evaluated to determine why some patients do and other patients do not develop CIN. Part 2 of this study will test the effects of a new treatment called photon stimulation (also called infrared light therapy) compared to placebo treatment to improve sensations in the feet of oncology patients with CIN. Role:Co-investigator

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator: Topp

NIH PCORI Allen (PI) 06/01/2012 - 05/30/2014 NIH Minding the Gap: Targeting Differences Between Patients' Current and Perceived Abilities This study develops the 6-dimensional Movement Assessment Measure into a web-based platform, and uses the assessment in the UCSF Physical Therapy Faculty Practice and Health and Wellness Center. The study will apply principles of patient preferences and goals to facilitate physical therapists' patient care and improve health outcomes. Role:Co-Investigator Completed Research Support

R01 NS039278 Noble-Haeusslein (PI) 07/01/2004 - 04/30/2009 NIH, NINDS Role of matrix metalloproteinases in spinal cord injury Role:Co-investigator R01 NR008286 11/01/2003 - 10/31/2007 NIH/NIDDK Comparison of exercise responses in four end-stage renal disease treatments Role:Co-investigator, (Painter Individual Investigator Grant 11/01/2001 - 10/31/2002 UCSF Academic Senate Contribution of neuronal intermediate filaments to vincristine-induced peripheral neuropathy Role:Principal investigator K01 HD01162 11/01/1997 - 10/31/2002 NIH/NICHD Role of axonal transport in peripheral nerve function Role:Principal investigator

PHS 398/2590 (Rev. 06/09) Page 5 Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Zinaida S. Vexler, Ph.D. Professor In Residence eRA COMMONS USER NAME Vexler EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Moscow State University, Dept. of Chemistry M.S. 1979 Chemistry Institute of Biophysics, Ministry of Health Ph.D. 1990 Biochemistry&Radiobiolog University of California, San Francisco, CA Postdoc 1990-1995 Neuropharmacologyy University of California, San Francisco, CA Postdoc 1995-1996 Signal Transduction A. Personal Statement Over the last twenty years, my research has been centered on the mechanisms of experimental stroke with the long-term goal of developing effective therapies. I have contributed to the fields of brain vascular and cellular injury after experimental stroke first in the adult and, over more than fifteen years, in the neonate. I have multi-disciplinary training in chemistry, biochemistry, pharmacology, and physiology. I have served as Director of MRI Core on PPG since 2002, and as the Director of Research of Neonatal Brain Disorders Center at UCSF since 2003. My lab was the first to establish and characterize the in vivo model of neonatal focal stroke in rats, and ours is the only laboratory that can produce focal arterial stroke in neonatal mice. With these age appropriate models, we have recently shown that depletion of microglia before neonatal stroke does not limit neuroinflammation or protect and that in fact microglial cells contribute to endogenous defense mechanisms. We discovered that, strikingly, the blood-brain barrier (BBB) is markedly more intact after acute neonatal stroke than after adult stroke and that, based on the endothelial transcriptosome, the “signature” of genes that regulate BBB permeability is vastly different in acutely injured adult and neonatal brain. Also, we were one of the first to show that neuronal progenitor cells differentiate into a region-appropriate neuronal phenotype, but only a limited number of progenitor cells migrate to the injured cortex. We showed that angiogenesis is diminished and delayed after neonatal stroke and were able to modulate angiogenesis and neurogenesis and repair after neonatal stroke by enhancing it with erythropoietin and reducing angiogenesis and repair by inhibiting VEGFR2 signaling. Currently we are testing several hypotheses on how interactions between microglial cells and various components of the neurovascular unit affect short- and long-term injury outcome. To address some of the concepts we are developing in vivo imaging tools to longtitude tracking of immune cells. With the use of novel concepts, experimental models and imaging modalities we are uniquely positioned to advance the field of neonatal stroke. B. Positions and Honors. Professional Positions 1979-1981 Fellow Institute of Biophysics, Ministry of Health, USSR 1981-1990 Research Scientist Institute of Biophysics, Ministry of Health, USSR 1990-1995 Postgraduate Researcher University of California, San Francisco, CA 1995-1996 Postgraduate Researcher University of California, San Francisco, CA 1996-1999 Assistant Researcher Neurobiologist University of California, San Francisco, CA 1999-2002 Assistant Professor University of California, San Francisco, CA 2002-2010 Associate Professor University of California, San Francisco, CA 2010- Professor University of California, San Francisco, CA 2003-present Director of Research, Neonatal Brain University of California, San Francisco, CA Disorders Center 2008- Member, Biomedical Sciences University of California, San Francisco, CA Graduate Program

Honors and Service NIH/NICHD (2001) Study Section; Israel Science Foundation (2003, 2004); NIH NHLBI/NINDS Study Section (2005); American Heart Association, Western, Committee 1A (2004-2006); American Heart Association, Brain 3 (2006); Veteran Administration Medical Research Service/Department of Defense (2005, 2006, 2007, 2008); American Heart Association, Brain 2 (2008); American Heart Association, Brain 2, Co-Chair (2009); NIH 05 ZRG1 EMNR-N (2010, 2011); American Heart Association, Brain 3, Chair (2010, 2011), AHA Steering sub-committee (2012); DBD, Ad-hoc member NINDS/NIH (2012); BINP Ad-hoc member NINDS/NIH (2013), study section member, NINDS/NIH BINP (2014).

C. Selected Peer-reviewed Publications (from a total of 53) Most relevant 15 publications to the current application 1. Derugin N, Ferriero DM and Vexler ZS, "Neonatal reversible focal cerebral ischemia: a new model". Neurosci. Res., 1998, 32:349-353. 2. Derugin N, Muramatsu K, Wendland MF, Gregory G, Ferriero DM, Vexler ZS. “Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rat". Stroke, 2000, 31:1752-1761. 3. Parent J, Vexler ZS, Derugin N, Gong C, Ferriero FM. ‘Focal Cerebral Ischemia Increases Adult Rat Forebrain Subventricular Zone Neuroblast Proliferation and Induces Neostriatal Neurogenesis’. Ann Neurology, 2002, 52(6):802-813. 4. Manabat C, Han H, Wendland M, Derugin N, Holtzman D, Ferriero DM, Vexler ZS. “Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after focal ischemia in immature brain”. Stroke, 2003, 34:207-213. 5. Denker, Ji S, Lee SY, Dingman A., Derugin N, Wendland MF, Vexler ZS. “Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke”. J Neurochem. 2007, 100: 893-904. PMID: 17212701 6. Gonzalez F, McQuillen P, Mu D, Chang Y, Wendland M, Vexler ZS, Ferriero DM, “Erythropoietin enhances long-term protection and neurogenesis in neonatal stroke”. Dev Neurosci 2007, 29: 321- 330. PMID: 17762200 7. Wendland M, Faustino J, West T, Holtzman D, and Vexler ZS “Early diffusion-weighted MRI as predictor of caspase-3 activation following hypoxia-ischemia in neonatal rodents”. Stroke, 2008, 39:1862-1868. PMID: 18420950 8. Shimotake J, Derugin N, Wendland M, Vexler ZS* and Ferriero DM*. “Vascular Endothelial Growth Factor Receptor2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke”. Stroke, 2010, 41:343-349. * - co-senior authors. PMID: 20101028 9. Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS. "MRI as a Translational Tool for the Study of Neonatal Stroke" J Child Neurol, 2011, 26(9):1145-1153. PMID: 21670390 10. Faustino J, Wang X, Jonhson C, Klibanov A, Derugin N, Wendland M, Vexler ZS. “Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke”. J. Neurosci. 2011: 31:12992-13001. PMID: 21900578 11. Fernandez-Lopez D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro A, and Vexler ZS. “Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke”. Neurosci, 2012, 207:307-15. Epub 2012 Jan 12. PMID: 22285309 12. Fernandez-Lopez D, Faustino J, Daneman R, Zhou L, Derugin N, Wendland M, and Vexler ZS. “Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke” J. Neurosci, 2012, Jul 11; 32(28): 9588-9600. PMID: 22787045 13. Woo MS, Wang X, MD, Faustino J, Derugin N, Wendland M, Zhou P, Iadecola C, and Vexler ZS. “Genetic deletion of CD36 enhances injury after acute neonatal stroke“,Ann Neurol, 2012, 72:961- 970. PMID: 23280844

14. Fernández-López D, Faustino J, Derugin N, Vexler ZS. “Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat”. Translational Stroke Res, 2013, 4 (2):179-188. PMID: 23730350 15. van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. “Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke”. Stroke. 2013, 44(5):1426-32. PMID: 23539530

Review Articles and Recent Abstracts Directly Relevant to the Submission: 16. Vexler ZS, Yenari MA. Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci. 2009; 31(5):378-93. 17. Bowers KJ, Deveber GA, Ferriero DM, Roach ES, Vexler ZS, Maria BL “Cerebrovascular disease in children: recent advances in diagnosis and management”. J Child Neurol. 2011 Sep; 26(9):1074- 1100. 18. Fernández-López D and VexlerZS. “Inflammation after Acute Brain Injuries Affect the Developing Brain Differently than Adult Brain”. In “Immunological Mechanisms and Therapies in Brain Injuries and Stroke”, edited by Drs. Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, and John Zhang, 2013. 19. Fernández-López D and VexlerZS. “Blood-Brain Barrier and Stroke”. In “Blood Brain Barrier in Health and Disease”; Topics in Medicinal Chemistry, Springer, edited by Dr Gert Fricker, 2013. D. Research Support Ongoing Research Support

RO1NS044025-10 Vexler (PI) 9/01/02-2/28/18 Agency: NIH/NINDS Title of the Project: Neonatal Stroke: the role microglia. The goal of this grant is to determine if ablation of microglial cells, change in redox metabolism in these cells or depletion of the CD36 receptor on microglial cells exacerbate acute ischemia-reperfusion injury to the neonatal brain by limiting clearance of apoptotic neurons. Role: Principal Investigator

R01 NS076726-01 Vexler (PI) 7/1/12-6/30/17 Agency: NIH/NINDS Title of the Project: Macrophages as modulators of repair after neonatal stroke. The major goal of this project is to delineate the mechanisms of galectin-3 produced in microglia/macrophages on angiogenesis and repair after neonatal stroke. Role: Principal Investigator

1R21NS080015-01 Vexler (PI) 7/1/12-6/30/14 Agency: NIH/NINDS Title: Blood-brain barrier function after neonatal and pediatric experimental stroke The goal of this grant is to understand the role of brain maturation on the blood-brain barrier integrity in pediatric compared to neonatal stroke. Role: Principal Investigator

NS35902 (Ferriero PI; Vexler - Project Leader, Core B) 4/1/97-1/31/14 (no cost extension) Agency: NIH/NINDS Title of the Program Project: Mechanisms of Ischemic Neonatal Brain Injury. Core B: Magnetic Resonance Imaging Core. Role: Project Leader

P50 NS35902 Ferriero (PI) 4/1/97-1/31/14 (no cost extension) Agency: NIH/NINDS

Title of the Program Project: Mechanisms of Ischemic Neonatal Brain Injury. Project 2: Role of vascular derived growth factor in neonatal brain injury. The major goal of this project is to determine the role of the VEGF in regulating neurogenesis after hypoxic- ischemic injury in neonatal rats. Role: Co-Investigator Completed Research Support (last 3 years)

R01NS055915-01A2 Vexler (PI) 8/5/09-7/30/12 Agency: NIH/NINDS Title of the Project: CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke. The goal of this grant is to determine relationships between circulating CINC-1, neutrophil transmigration and blood-brain barrier integrity after neonatal stroke. Role: Principal Investigator

Grant-in-Aid Vexler (PI) 7/1/08-6/30/10 AHA Western Affiliates Title of the Project: “Macrophages as modulators of brain repair after neonatal stroke”. The goal of this grant was to identify the effect of monocyte deletion during an acute injury phase on long-term injury outcome after neonatal stroke. Role: Principal Investigator

Program Director/Principal Investigator: Wanek

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Wanek, Linda Professor eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Kansas University, Lawrence KS BS 1976 Physical Therapy University of North Carolina, Chapel Hill, N.C. MS 1980 Physical Therapy University of Southern California, Los Angeles PhD 1993 Anatomy/Cell Biology

A. Personal Statement Dr. Wanek teaches content related to pathokinesiological and musculoskeletal principles applied to physical therapy assessment and intervention for patients with musculoskeletal movement dysfunctions of the spine and lower quarter. She also teaches content related to the preparation of case reports as evidence to document best practice and clinical decision making. Wanek received her BS in Physical Therapy from the University of Kansas in 1976, her advanced MS in Physical Therapy with an emphasis in Sports Medicine and Biomechanics from the University of North Carolina, Chapel Hill in 1980 and her PhD in Anatomy and Cell Biology from the University of Southern California in 1993.

Wanek is a licensed physical therapist in California (#12880) and Nebraska (#357) and also held NATA certification until 2008. She participates in a number of continuing education activities related to her teaching area including attending the California APTA annual conferences, Orthopaedic Section of the APTA independent study courses on Orthopedic interventions for pediatric patients, current concepts for orthopedic physical therapy and conservative management of the foot, along with courses on Ethics and Best practice and law tutorials. Over 30 years as a physical therapist, Wanek has worked extensively in the clinic with patients having musculoskeletal movement dysfunctions. At SFSU she has provided services to the SFSU student population through the Student Health Service. Since becoming Chair of the SFSU PT program in 2002, Dr. Wanek has reduced her hours in the clinic but continues to provide consultations to students, faculty, and staff.

Dr. Wanek’s research interests have stemmed from her experience as a physical therapy clinician. Her pursuit of a PhD in Anatomy and Cell Biology from the University of Southern California was directly related to an interest in muscle atrophy post- injury and the lack of full muscle girth recovery that is often seen post-rehabilitation. Her doctoral work and early research activity at SFSU were in the areas of muscle regeneration. Her clinical work along with her teaching expertise in musculoskeletal movement dysfunctions in the lower quarter led to work in the area of low back pain in young adults, adolescents, and children. Dr. Wanek has presented a number of posters on the issue of low back pain. Most recently poster presentations addressing the issues of musculoskeletal risk factors and impact of low back pain on quality of life in young adults were presented at California APTA annual conferences. Wanek also has an interest in the use of case reports as evidence to document best practices and clinical decision making and has worked with several 3rd year students to develop their case reports into presentations or publications.

Wanek has participated in a number of consultation and service activities related to her teaching areas, including participating in the TRUST San Quentin Health Fair, Physical Therapy Services at Valencia Health Services, and Physical Therapy Clinic at Mission High School Health Center. She is also a member of the APTA, CPTA, and Golden Gate District along with membership in the Orthopaedic, Sports PT, and Education sections. At the University she is an elected member of the Academic Senate representing the College of Health and Social Sciences. She also sits on the Academic Policy Committee of the Senate. Dr. Wanek has also served on University-wide strategic planning and search committees. As a past member of Graduate Council, Wanek played a lead role in revising the Paired Course Policy and establishing a SFSU Graduate Fellowship program to provide scholarships to graduate students demonstrating excellence in their academic work. In the College of Health and Social Sciences she is a member of Chairs Council and in the Program she works closely with Dr. Galvan to provide pre-PT advising to undergraduate and high school students. She also works with campus and high school health fairs to provide educational information and musculoskeletal health screenings. PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Wanek

Wanek has been a PT educator for 20 years. She teaches first-year, second year, and third year students and received the Sarlo Award for Excellence in Teaching at SFSU in 2009. Wanek utilizes teaching methods including lecture, large and small group discussions, self-directed learning, hands-on laboratory experiences, and online lecture style videos. Student evaluations of her primary teaching content areas have always been high and have exceeded the average core faculty teaching means. Peer evaluations of her teaching have also been excellent. B. Positions and Honors Principal Positions Held Dates Institution and Location Title Faculty Rank Tenure Status 2007- San Francisco State University, Physical Professor Professor Tenure present Therapy 2003- San Francisco State University, Physical Associate Chair Tenure track present Therapy Professor 2002- San Francisco State University, Physical Associate Interim Chair Tenure track 2003 Therapy Professor 1999- San Francisco State University, Physical Associate Associate Tenure track 2007 Therapy Professor Professor 1993- San Francisco State University, Physical Assistant Assistant Tenure track 1999 Therapy Professor Professor

Other Positions Held Concurrently Dates Institution and Location Title Faculty Rank Tenure Status 2007- Assoc. Clin. Associate Non-tenure Univ. of California San Francisco present Prof. Professor track 1993- Assistant Clin. Assistant Non-tenure Univ. of California San Francisco 2007 Prof. Professor track

Honors Awards 2009 San Francisco State Univ. Sarlo Excellence in Teaching Award

Memberships 1975-present American Physical Therapy Association 1993-present APTA Sports Medicine Section 1993-present APTA Orthopedics Section 2002-present APTA Education Section 1993-present California Chapter, APTA 1993-2008 American College of Sports Medicine 1978-2008 National Athletic Trainers Association

C. Peer-Reviewed Publications 1. Geriatric Rehabilitation and Resilience from a Cultural Perspective by Darlene Yee-Melichar, Andrea Renwanz Boyle, Linda J. Wanek, and Sarah B. Pawlowsky 2. Submitted to Topics in Geriatric Rehabilitation in Fall 2013Boyd BS, Gray AT, Dilley A, Wanek L, Topp KS. The pattern of tibial nerve excursion with active ankle dorsiflexion is different in older people with diabetes mellitus. Clinical Biomechanics (in press 2012). 3. Boyd BS, Wanek L, Gray AT, Topp KS. Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. BMC Neurology 10:75, 2010.

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator: Wanek

4. Smoot B, Wong J, Cooper B, Wanek L, Topp K, Byl N, Dodd M. Upper extremity impairments in women with or without lymphedema following breast cancer treatment. J Cancer Surviv. 4(2):167-178, 2010. 5. Katzman WB, Wanek L, Shepherd JA, Sellmeyer DE. Age-related hyperkyphosis: Its Causes, consequences and management. JOSPT 40(6):352-360, 2010. 6. Boyd BS, Wanek L, Gray AT, Topp, KS. Mechanosensitivity of the lower extremity nervous system during straight leg raise neurodynamic testing in healthy individuals. JOSPT 39(11):780-790, 2009. 7. Estilaei SK, Wanek L, Andrade CK. Spinal Accessory Nerve Injury in a Patient with Burkitt’s Lymphoma Presenting with Multiple Concurrent Issues. Rehabilitation Oncology 25(1):8-20, 2007. 8. Katzman WB, Sellmeyer DE, Stewart AL, Wanek L, Hamel KA. Changes in Flexed Posture, Musculoskeletal Impairments and Physical Performance Following Group Exercise in Community-Dwelling Older Women. Archives Phys Med and Rehab 88:192-199, 2007. 9. Wanek L. and Snow MH. Activity induced fiber regeneration in rat soleus muscle, Anat. Rec. 258:176-185, 2000. 10. Wanek L. and Snow MH. Presence of embryonic myosin in normal muscles of the rat, Cell and Tissue Research, 280:541-548, 1995.

D. Research Support Completed Research Support Expanding CSU Allied Health Program 1/1/2010-3/32/2011 CLS; Employment Development Dept. $143,132 direct State of California

Healthcare Laboratory Workforce Initiative 3/1/2010-3/31/2011 Clinical Laboratory Science Training Grant $42,945 direct

Healthcare Laboratory Workforce Initiative 2007-2008 Clinical Laboratory Science Training Grant $46,889 direct Healthcare Laboratory Workforce Initiative 2006-2007 Clinical Laboratory Science Training Grant $49,988 direct

SFSU Research and Development Grant 1998-1999 Therapeutic US and skeletal muscle regeneration $2800 direct

SFSU Research and Development Grant 1995-1996 Early peripheral nerve and muscle changes post injury $5000 direct

SFSU Research and Development Grant 1994-1995 US and skeletal muscle healing $5000 direct

SFSU Research and Development Grant 1993-1994 Reduced muscle activity and muscle regeneration $5000 direct

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Midori A. Yenari, MD Professor eRA COMMONS USER NAME (credential, e.g., agency login) YENARI.MIDORI EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Massachusetts Institute of Technology SB 1985 Mech. Engineering Tulane University School of Medicine MD 1989 Medicine Hospital of St. Raphael Internship 1990 Internal Medicine Stanford University School of Medicine Residency 1993 Neurology Stanford University School of Medicine Fellowship 1995 Cerebrovascular Fellow A. PERSONAL STATEMENT: I am a neurologist and physician scientist with laboratory training in neuroscience and stroke. I have over 15 years of experience in brain injury models, both in vitro and in vivo. A focus of my research has been to understand the pathomechanisms of stroke and neuroprotection as it pertains to inflammation. More recently, this work has expanded into the area of recovery and repair following stroke and TBI. I have mentored many undergraduate, graduate and medical students, as well as post docs at UCSF, UC Berkeley, MIT and Stanford. I have held appointments in the Biomedical Sciences Program at UCSF, and in the Neurosciences Program at Stanford. I have participated in journal club presentations, oral examinations, and rotations of graduate students through my laboratory. In addition, I serve as neurology ward attending for the student neurology rotation at the San Francisco VAMC. I have also participated in a new mini course this past fall on Brain Injury that was open to graduate students, postdoctoral fellows, residents, and technicians, and have served as faculty facilitator for the Dept of Neurology’s Brain, Mind & Behavior Course.

B. POSITIONS & HONORS

1993 Sandoz Award for Superior Academic Achievement and Contribution to Health Care 1994-1995 National Stroke Association Research Fellowship Award, “Thrombolytics and Antithrombins in a Rabbit Stroke Model” 1995-1997 Acting Assistant Professor, Departments of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 1998-2003 Assistant Professor (Research), Departments of Neurosurgery, Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 1999 American Heart Association Bugher Foundation Award Review Committee 2001 NIH/NINDS, Clinical Trials Review Committee (ZNS1 SRB-K) (2001) 2001-2003 American Heart Association National Peer Review: Brain Study Group 2002-06, 11-15 NIH/NINDS, Neurological Sciences and Disorders A (NSD-A) Review Committee 2002 Women’s International Scientific Cooperation (WISC) travel grant award, American Association for the Advancement of Science 2003-06,10-13 Editorial Board, Section editor for Translational Research, Stroke 2003 Member, American Neurological Association 2004 Associate Professor (Research), Departments of Neurosurgery, Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 2004-2010 Associate Professor, Department of Neurology, University of California, San Francisco, CA 2005-2009 Editorial Board, Neurobiology of Disease 2005-2012 Editorial Board, Journal of Cerebral Blood Flow and Metabolism 2007-2011 NIH/CSR, Brain Injury and Neurovascular Pathologies Study Section (BINP), charter member 2009 Fellow, American Academy of Neurology 2009 Editorial Board, Translational Stroke Research 2009-2013 Editorial Board, World Journal of Cardiology 2010 Editorial Board, Therapeutic Hypothermia 2010 Professor, Department of Neurology, University of California, San Francisco, CA 2011 Editorial Board, Anatomy and Cell Biology 2012 Director, San Francisco VAMC Stroke Center

C. PEER-REVIEWED ARTICLES (selected from over 100 peer reviewed publications)

Yenari MA, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, Onley D, Ho DY, Sapolsky RM & Steinberg GK, Gene therapy with Hsp72 is neuroprotective in rat models of stroke and epilepsy, Ann Neurol (1998) 44(4):584-591 Hoehn, B, Ringer TM, Xu LJ, Giffard RG, Sapolsky RM, Steinberg GK, Yenari MA, The overexpression of HSP72 after the induction of experimental stroke protects neurons from ischemic damage, J Cereb Blood Flow Metab (2001) 21:1303-1309 Zhang ZJ, Sobel RA, Cheng D, Steinberg GK, & Yenari MA, Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia, Mol Brain Res (2001) 95(1-2):75-85 Kelly S, Zhang Z, Zhao H, Xu L, Giffard RG, Sapolsky RM, Yenari MA, Steinberg GK, Gene Transfer of HSP72 Protects CA1 Neurons from Global Ischemia: Influence of Bcl-2 Ann Neurol (2002) 52:160-167 Yenari MA, Iwayama S, Maier CM, Cheng D, Sun GH, Fujimura M, Morita-Fujimura Y, Chan PH, Steinberg GK, Influence of mild hypothermia on Bcl-2/Bax expression, cytochrome c release and caspase activation following experimental stroke, J Cereb Blood Flow Metab (2002) 22:29-38 Han HS, Qiao Y, Giffard RG, Yenari MA, Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation, J Neurosci (2002) 22(10):3921-3928 Xu L, Yenari MA, Steinberg GK, & Giffard RG, Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade, J Cereb Blood Flow Metab (2002) 22:21-28 Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA, Mild hypothermia inhibits nuclear factor-kB translocation in experimental stroke, J Cereb Blood Flow Metab (2003) 23:589-598 Deng H, Han HS, Cheng D, Sun GH, Yenari MA, Mild Hypothermia Inhibits Inflammation Following Experimental Stroke and Brain Inflammation, Stroke (2003) 34:2495-2501 Kelly S, Bliss TM, Shah AK, Sun GH, Ma M, Foo WC, Yenari MA, Weissman IL, Uchida N, Palmer T, Steinberg GK, Transplanted human fetal neural stem cells survive, migrate and differentiate in ischemic rat cerebral cortex, Proc Nat Acad Sci (2004) 101(32):11839-44 Lee JE, Kim YJ, Kim JY, Lee WT, Yenari MA, Giffard RG, The 70 kD heat shock protein suppresses matrix metalloproteinases in astrocytes, Neuroreport (2004) 15:499-502 Zhao H, Yenari MA, Cheng D, Sapolsky RM, Steinberg GK, Bcl-2 transfection via herpes simplex virus blocks apoptosis inducing factor translocation after focal ischemia in rats, J Cereb Blood Flow Metab (2004) 24(6):681-92 Bright R, Raval AP, Dembner JM, Perez-Pinzon MA, Steinberg GK, Yenari MA, Mochly-Rosen D, Protein kinase C δ mediates cerebral reperfusion injury in vivo, J Neurosci (2004) 24(31):6880-8 Kelly S, Zhao H, Sun GH, Cheng D, Qiao Y, Luo J, Martin K, Steinberg GK, Harrison SD, Yenari MA, Glycogen synthase kinase 3β inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity and cerebral ischemia, Exp Neurol (2004) 188:378– 386 Kelly S, Cheng D, Steinberg GK, Yenari MA, Mild Hypothermia Alters GSK3β Expression Following Global Cerebral Ischemia, Neurocritical Care (2005) 2(2):212-7 Zhao H, Yenari MA, Cheng, Sapolsky RM, Steinberg GK, Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia, J Cereb Blood Flow Metab (2005) 25:1119-29 Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG, Microglia potentiate damage to blood brain barrier constituents: improvement by minocycline in vivo and in vitro, Stroke (2006) 37(4):1087-93 Zheng Z, Yenari MA, The application of HSP70 as a target for gene therapy, Front Biosci. (2006)11:699-707 Tang XN, Yenari MA, Inflammation in stroke, In Yenari MA, Giffard RG (Eds), Glia and inflammation in neurodegenerative disease, Nova Science Publishers, Inc., Hauppauge, NY (2006) 85-115 Liu L, Yenari MA, Therapeutic hypothermia: neuroprotective mechanisms, Front Biosci. (2006) 12:816- 25 Zhao H, Wang J, Shimohata T, Sun G, Yenari MA, Sapolsky RM, Steinberg GK, Conditions of protection by hypothermia and effects on apoptotic pathways in a model of permanent middle cerebral artery occlusion, J Neurosurg (2007) 107:636-641 Tang XN, Wang Q, Koike MA, Cheng D, Goris ML, Blankenberg FG, Yenari MA, Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia (2007) 48(11):1822-8 Wang Q, Tang XT, Yenari MA, The inflammatory response in stroke, J Neuroimm (2007) 184:53-68 PMC1868538 Han HS and Yenari MA, Effect of gene expression on therapeutic hypothermia in cerebral ischemia, Future Neurology (2007) 2(4):435-440 Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg, GK, Lee JE, Yenari MA, Mild hypothermia inhibits FasL shedding in experimental stroke, J Neurochem (2008) 106:541-50 Tang XN, Cairns B, Cairns N, Midori A. Yenari MA, Apocynin improves outcome in experimental stroke with a narrow dose range, Neuroscience (2008) 154:556-562 Bright R, Sun G, Yenari MA, Steinberg GK, Mochly-Rosen D, PKC confers acute tolerance to cerebral ischemic reperfusion injury, Neurosci Lett (2008) 441:120-124 PMC2597630 Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA, Glucose and NADPH oxidase drive neuronal superoxide formation in stroke, Ann Neurol (2008) 64:654-63 Zheng Z, Kim JY, Ma H, Lee JE, Yenari MA, Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke, J Cereb Blood Flow Metab (2008) 28(1):53-63 Yenari MA, Kitagawa K, Lyden PD, Perez-Pinzon M, Metabolic down regulation: A key to successful neuroprotection? Stroke (2008) 39:2910-2917 PMC2597567 Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA, Glucose and NADPH oxidase drive neuronal superoxide formation in stroke, Ann Neurol (2008) 64(6):654-663 Tang XN, Liu L, Yenari MA, Combination therapy with hypothermia for treatment of cerebral ischemia, J Neurotrauma (2009) 26:325-31 Hsieh C, Koike M, Spusta S, Niemi E, Yenari M, Nakamura M, and Seaman W, A role for TREM2 ligands in the phagocytosis of neuronal cells by microglia, J Neurochem (2009) 109:1144-56 NIHMSID:104493 Wang Q, van Hoecke M, Tang XN, Lee H, Zheng Z, Swanson RA, Yenari M, Pyruvate protects against experimental stroke via an anti-inflammatory mechanism, Neurobio Dis (2009) 36(1):2223-31 PMC2742567 Webster CM, Kelly S, Koike M, Chock V, Giffard RG, Yenari MA, Inflammation and NFkB activation is decreased by hypothermia following global cerebral ischemia Neurobio Dis (2009) 33:301-12 Tang XN, Berman A, Swanson RG, Yenari MA, Digitally quantifying cerebral hemorrhage using Photoshop and Image J, J Neurosci Methods (2010) 190:240-43 Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA, Direct protection of cultured neurons form ischemia-like injury by minocycline, Anat and Cell Biol (2010) 43(4):(325-31) Yenari MA, Kaupinnen TM, Swanson RA, Microglial activation in stroke: therapeutic targets, Neurotherapeutics (2010) 7:378-91 Kacimi R, Giffard RG, Yenari MA, Endotoxin activated microglia injure brain derived endothelial cells via NF- κB, JAK-STAT and JNK stress kinase pathways, J Inflammation (2011) 8:7 Shah MP, Zimmerman L, Bullard J, Yenari MA, Therapeutic hypothermia after cardiac arrest: Experience at an academically-affiliated community-based Veterans Affairs Medical Center, Stroke Research and Treatment (2011) Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA, Hyperglycemia promotes tissue plasminogen activator- induced brain hemorrhage by increasing superoxide production, Ann Neurol (2011) 70:583-590 Tang XN, Zheng Z, Zu L, Giffard RD, Yenari MA, NADPH oxidase from marrow derived blood cells contributes significantly to ischemic worsening in experimental stroke Ann Neurol (2011) 70:606-15 Kim JY, Kim N, Yenari MA, Chang W, Mild hypothermia suppresses calcium sensing receptor (CaSR) induction following forebrain ischemia while increasing GABA-B receptor1 (GABA-B-R1) expression, Translational Stroke Research (2011) 2:195-201 Yenari MA, Han HS, Neuroprotective mechanisms of hypothermia in brain ischemia, Nature Rev Neurosci (2012) 13(4):267-78 Kim JY, Kim N, Yenari MA, Chang W, Hypothermia and pharmacological regimens that prevent overexpression of the extracellular calcium-sensing receptor (CaSR) protect neurons against traumatic brain injury, J Neurotrauma (2013) 30(13):1170-6 Tang XN, Liu L, Koike MA, Yenari MA, Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and BBB disruption after experimental stroke, Therapeutic Hypothermia and Temperature Management (2013) 3(2):74-83 Kim JY, Kim N, Lee JE, Yenari MA, The 70kD heat shock protein protects against experimental traumatic brain injury, Neurobiology of Disease (2013) 58C:289-95 Webster CM, Hokari M, McManus A, Tang XN, Ma H, Kacimi R, Yenari MA, Microglial P2Y12 deficiency/inhibition protects against brain ischemia, PLoS ONE (2013) 8(8):e70927 Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CS, Nakamura MC, Yenari MA, Triggering receptor expressed on Myeloid Cells-2 (TREM-2) correlates to hypothermic neuroprotection in ischemic stroke Therapeutic Hypothermia and Temperature Management (2013) 3(4):189-98

D. RESEARCH SUPPORT (past 3 years)

Ongoing Research Support R01 NS40516 (Yenari, PI) 8/15/01-5/31/15 NIH NINDS Inflammatory Mechanisms in Cerebral Ischemia. The major goals of this project are to study the inflammatory mechanisms of TREM-2 in vitro and in vivo following experimental stroke. VA REAP (Swanson, PI) 07/01/09-06/30/14 “Multimodel strategies for improving recovery from brain injury” (Yenari, participating investigator) This is a multi-PI project to study potential rehabilitative therapies plus pharmacological therapies to improve outcome from experimental stroke.

1 I01 BX000589 (Yenari, PI) 1/01/11-09/30/15 VA Merit “Heat shock proteins in brain ischemia and stroke” The major goals of this project are to explore the roles played by HSP70 in brain ischemia as it pertains to blood brain barrier integrity.

Completed Research Support P50 NS014543 (P.H. Chan, PI) 9/27/02-6/30/12 NIH/NINDS “CNS Injury and Edema Research Center” (Projects 2 & 3, Yenari, collaborator) This project will examine the contribution of inflammation to blood brain barrier damage in stroke models.

DOD DAMD17-03-1-0532 (Yenari, PI) 5/01/09-4/30/11 DOD “Regulation of matrix metalloproteinases by heat shock proteins in TBI” This project will examine the role of HSP70 in suppressing matrix metalloproteinases in experimental brain trauma.

0540066N (Yenari) 1/1/05-12/31/09 American Heart Association Established Investigator Award Mechanisms of heat shock protein protection The major goals of this project are to study the mechanism by which heat shock proteins interact with the inflammatory transcription factor nuclear factor kappa B.

P01 NS37520 (G. K. Steinberg) 3/1/04-2/28/09 NIH/NINDS "Center for Cerebrovascular Disease" (Project 1, Yenari, collaborator) The goals of this project are to understand the molecular mechanisms underlying the pathogenesis of cerebral ischemia. Appendix E: Letters of Support from Schools, Departments and Programs

Enclosed Letters of Support Include:

Program Directors • Jason Cyster, PhD, Program Director of PhD in Biomedical Sciences • Tejal Desai, PhD, Program Director of Master in Translational Medicine • Chris Diederich, PhD, co-Chair of UCSF/UCB Graduate Program in Bioengineering • Maria Glymour, PhD, Program Director of PhD in Epidemiology and Translational Science • Roger Nicoll, PhD, Program Director of PhD in Neuroscience • Mitul Kapadia, MD, Clinical Director, Physical Medicine and Rehabilitation Program

Deans • Elizabeth Watkins, PhD, Dean, Graduate Division • Sam Hawgood, MBBS, Dean, School of Medicine • John Featherstone, MSc, PhD, Dean, School of Dentistry • Joseph Guglielmo, PharmD, Dean, School of Pharmacy • David Vlahov, RN, PhD, FAAN, Dean, School of Nursing

Department Chairs • Ronald Arenson, MD, Chair, Department of Radiology and Biomedical Imaging • Mitchell Berger, MD, Chair, Department of Neurological Surgery • Stephen Hauser, MD, Chair, Department of Neurology • Thomas Vail, MD, Chair, Department of Orthopaedic Surgery

San Francisco State University • Linda Wanek, PT, PhD, Chair, Department of Physical Therapy at SFSU and Ann Hallum, PT, PhD, Dean, Graduate Studies at SFSU

Notes of Support from Basic Science Department Chairs and Basic Science Program Directors

Biomedical Sciences Graduate Program January 22, 2014 513 Parnassus Avenue Box 0505, Room HSE-1285 UCSF Graduate Council San Francisco, CA 94143- Academic Senate Office 0505 UCSF Box 0764, MUE Room 253

San Francisco, CA 94143 Tel: (415) 476-8467 Fax: (415) 502-7970 Dear Council Members,

I write as Director of the PhD Program in Biomedical Sciences (BMS) at UCSF to enthusiastically support this proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of

California, San Francisco. Having discussed the proposal with Dr. Topp and her colleauges, I have learnt that this degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically informed neuroscience, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Neuroscience, and Bioengineering. I am happy to add the BMS graduate program to this list. I was also pleased to hear that the PhD in Rehabilitation Science program will draw on the existing partnership between UCSF and San Francisco State University, and

will provide students with the necessary skills to become leaders and researchers in rehabilitation within the dynamic new American health care system.

The BMS program seeks to equip students with the training and research tools to study the function of tissue and organ systems in development, physiology, and disease. The goals of our programs are in many ways complementary, and I see a range of opportunities for collaboration in our training efforts.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our PhD students have an interest in anatomy, neuroscience, and biomechanics, and the proposed program provides educational opportunities for our students and others at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Jason Cyster, PhD Program Director, PhD in Biomedical Sciences Professor, Department of Microbiology & Immunology

Schools of Pharmacy and Medicine Bioengineering and Therapeutic Sciences

January 31, 2014

Tejal Desai, Ph.D, Professor

1700 4th Street, Byers Hall, Room 203C UCSF Graduate Council San Francisco, CA 94158-2550 tel: 415-514-4503 Academic Senate Office fax: 415-514-9658 email: [email protected] UCSF Box 0764, MUE Room 253

San Francisco, CA 94143

Dear Council Members,

I enthusiastically write to s upport this proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically informed neuroscience, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering. The PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders and researchers in rehabilitation within the dynamic new American health care system. I serve as Program Director of the UCSF Master of Translational Medicine Program, which is a multidisciplinary program focusing on technology and building the skills to navigate the challenges inherent in translating research from bench to bedside. Additionally, I am a core faculty member of the PhD Program in Bioengineering, which provides opportunities for basic and applied bioengineering research in a wide variety of related fields which reflect the strengths and breadth of program faculty. The goals of the PhD in Rehabilitation Science are in line with the MTM and PhD in Bioengineering programs, and this new program offers opportunity for collaboration between our graduate programs and the PhD Rehabilitation Science.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our students have an interest in anatomy, neuroscience, and biomechanics, and the proposed program provides educational opportunities for our students and others at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future. Sincerely,

Tejal Desai, PhD Program Director, Master in Translational Medicine Program Core Member, UCB/UCSF Graduate Group in Bioengineering Professor, Bioengineering & Therapeutic Sciences Professor, Physiology

January 22, 2014

UCSF Graduate Council Chris J Diederich, PhD Professor & Director Academic Senate Office Clinical Hyperthermia Physics & Thermal Therapy Research UCSF Box 0764, MUE Room 253 Radiation Oncology Department San Francisco, CA 94143

University of California, San Francisco 1600 Divisadero St. Dear Council Members, MZ Bldg H1031, Box 1708 San Francisco, CA 94143-1708 tel: 415-476-8641 The purpose of this letter is to enthusiastically state my support toward this proposal for the new degree [email protected] program, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically informed neuroscience, while also providing students access to coursework and professional colleagues

in a variety of graduate programs, such as Bioengineering, Biomedical Sciences, Neuroscience, and

Epidemiology. This PhD in Rehabilitation Science program would build on the existing partnership

between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders and scientific research experts in the field of rehabilitation within the ever dynamic new American health care system.

I am co-Chair of the UCB-UCSF Bioengineering Graduate Group for the joint PhD Program in Bioengineering at UCSF and UCB. This program provides opportunities for basic and applied bioengineering research in a wide variety of related fields, with close to 100 core faculty members, which reflect the strengths and breadth of program faculty across both campuses. The stated goals of the PhD in Rehabilitation Science are well in line with the PhD program in Bioengineering, and this new program offers opportunity for collaboration between our graduate program and the PhD Rehabilitation Science program.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our PhD students have an interest in

anatomy, neuroscience, and musculoskeletal biomechanics, and the proposed program provides

additional and complementary educational opportunities directly applicable for our students and others

at UCSF who are interested in courses within these subject areas. I believe this PhD will further advance our working relationships and integration across programs, and facilitate inter-professional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program at UCSF will address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Chris Diederich, PhD Co-Chair, UCB-UCSF Joint Graduate Program in Bioengineering Core Member, UCB/UCSF Graduate Group in Bioengineering Professor, Radiation Oncology University of California San Francisco

Department of Epidemiology & Biostatistics China Basin Landing

M. Maria Glymour, S.D. UCSF Graduate Council Associate Professor Academic Senate Office Department of Epidemiology & Biostatistics UCSF Box 0764, MUE Room 253 Director, Epidemiology and San Francisco, CA 94143 Translational Science PhD January 31, 2014 Program

Dear Council Members, University of California, San Francisco I enthusiastically write to support this proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation UCSF Box 0560 Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, 185 Berry Street, Lobby 5 Suite 5700 San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal San Francisco, CA 94107 biomechanics and clinically informed neuroscience, while also providing students access to coursework and

415/514-8014 tel professional colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, [email protected] Neuroscience, and Bioengineering, by allowing them to choose a curriculum tailored to their needs. The PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders and researchers in rehabilitation within the dynamic new American health care system.

I direct the PhD Program in Epidemiology and Translational Science at UCSF, in which doctoral students receive high caliber training in core skills of epidemiologic and biostatistical methods along with opportunities for practical experience in applied research and public health translational activities. The goals of the PhD in Rehabilitation Science are in line with the PhD in Epidemiology and Translational Science, and this new program offers opportunity for collaboration between our graduate program in Epidemiology and the PhD Rehabilitation Science.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our PhD students have an interest in anatomy, neuroscience, and biomechanics, and the proposed program provides educational opportunities for our students and others at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with the PhD in Rehabilitation Science program in the future.

Sincerely,

Maria Glymour, ScD Program Director, PhD in Epidemiology and Translational Science Associate Professor Department of Epidemiology and Biostatistics

University of California San Francisco

UCSF Cellular and Molecular Pharmacology

UCSF Graduate Council January 27, 2014 Academic Senate Office

UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Roger A. Nicoll, M.D. Professor Dear Council Members,

UCSF Mission Bay Campus I enthusiastically write to support this proposal for the new degree, Doctor of 600 16th Street Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy Box 2140, GH-N272D and Rehabilitation Science at the University of California, San Francisco. This degree San Francisco, CA 94158-2140 is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically informed neuroscience, while also providing students TEL: 415.476.2018 FAX: 415.502.8644 access to coursework and professional colleagues in a variety of graduate programs, [email protected] such as Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering, by allowing them to choose a curriculum tailored to their needs. The PhD in Rehabilitation

Science program draws on the existing partnership between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders

and researchers in rehabilitation within the dynamic new American health care system. I direct the PhD Program in Neuroscience at UCSF, in which doctoral students

are trained to be experts in one particular approach to neuroscientific research, while also having a strong general background in other areas of neuroscience and related disciplines. The goals of the PhD in Rehabilitation Science are in line with the PhD in Neuroscience, and this new program offers opportunity for collaboration between our graduate program in Neuroscience and the PhD Rehabilitation Science. I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our PhD students have an interest in anatomy, neuroscience, and biomechanics, and the proposed program provides educational opportunities for our students and others at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities. The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation. I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Roger Nicoll, MD Program Director, Graduate Ptogram in Neuroscience Professor Department of Cellular and Molecular Pharmacology

January 31, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I enthusiastically write to support this proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically informed neuroscience, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering. The PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders and researchers in rehabilitation within the dynamic new American health care system.

I am an Assistant Clinical Professor of Pediatrics and the Clinical Director of Pediatric Rehabilitation at the UCSF Benioff Children’s Hospital. I am a pediatric physiatrist, specializing in physical medicine and rehabilitation for infants, children and adolescents and treating disabling conditions, such as brain and spinal cord injuries, rheumatologic disorders, amputations or limb deficiencies, cancer, neurologic conditions, and orthopedic and musculoskeletal conditions. In this role, I work closely with the Physical Therapy department in the UCSF Medical Center and I can see the opportunities for collaboration with PhD students in the clinically-informed neuroscience track of the proposed PhD in Rehabilitation Science.

I am particularly enthusiastic about the benefits and opportunities generated by requiring students to participate in laboratory rotations in labs across the university. The proposed program provides educational opportunities for students to learn from a number of researchers across the University. I believe this PhD will further advance my working relationship with the Department of Physical Therapy and Rehabilitation Science and help us embrace interprofessional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Mitul Kapadia, MD Assistant Clinical Professor Department of Pediatrics Clinical Director, Physical Medicine and Rehabilitation Program UCSF Benioff Children’s Hospital

University of California, San Francisco Office of the Dean, School of Dentistry Box 0430, 513 Parnassus Avenue, Room S630 San Francisco, CA 94143-0430 Phone 415-476-1323/Fax 415-476-4226 e-mail: [email protected]

January 30, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I am writing to support the proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically- informed neuroscience, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering. I an pleased to see that the PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, while building on the strengths of basic science programs across UCSF, and facilitating connections between the basic and clinical sciences. The PhD program will help address the growing need for research faculty in Physical Therapy programs and investigators who can contribute to the body of research in the interdisciplinary field of rehabilitation.

The goals of this program are in line with the vision and mission of UCSF, and this new program offers opportunity for collaboration across the University. The four professional schools and the Graduate Division have worked closely together to meet the needs of our students and the populations we serve, and this program will continue to strengthen those relationships. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to watching this degree program grow through strong collaborations across schools and programs.

Yours Sincerely,

John D. B. Featherstone, M.Sc., Ph.D. Dean and Distinguished Professor UCSF School of Dentistry

University of California

San Francisco

School of Pharmacy Office of the Dean

B. Joseph Guglielmo, PharmD January 29, 2014 Dean Troy C. Daniels Distinguished Professor in Pharmaceutical UCSF Graduate Council Sciences Academic Senate Office 521 Parnassus Avenue Box 0622, Room C-156 UCSF Box 0764, MUE Room 253 San Francisco, CA 94143-0622 San Francisco, CA 94143 tel: 415/476-8010 fax: 415/476-6632 [email protected] http://pharmacy.ucsf.edu Dear Council Members,

I am writing in strong support of this proposal for the new degree, Doctor of

Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This unique

interdisciplinary endeavor will offer new coursework in musculoskeletal biomechanics and clinically-informed neuroscience, while also providing students access to coursework and professional colleagues in other graduate programs, including Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering.

The PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, while building on the strengths of core science programs across UCSF, and facilitating connections between the basic and clinical sciences. The PhD program will help address the growing need for research faculty in Physical Therapy programs and investigators who can contribute to the body of research in the interdisciplinary field of rehabilitation.

The goals of this program are in line with the vision and mission of UCSF, and this new program offers opportunity for collaboration across the University. The four professional schools and the Graduate Division have worked together to meet the needs of our students and the populations we serve, and this program will continue to strengthen those relationships. This PhD will further advance relationships across programs toward optimal interprofessional collaboration and educational activities.

I offer my enthusiastic support for the development of this novel program, and I look forward to its development.

Sincerely,

B. Joseph Guglielmo, PharmD Dean Troy C. Daniels Distinguished Professor in Pharmaceutical Sciences

MITCHEL S. BERGER, MD Chairman

Adult Brain Tumors Manish K. Aghi, MD, PhD Mitchel S. Berger, MD January 28, 2014 Sandeep Kunwar, MD Michael W. McDermott, MD Philip Theodosopoulos, MD

Brain and Spinal Injury Sanjay Dhall, MD Gregory Hawryluk, MD, PhD Michael Huang, MD UCSF Graduate Council Geoffrey T. Manley, MD, PhD Academic Senate Office Cerebrovascular Disorders Michael T. Lawton, MD Michael Huang, MD UCSF Box 0764, MUE Room 253

Epilepsy and Pain San Francisco, CA 94143 Edward F. Chang, MD

Neuro-oncology Anuradha Banerjee, MD Dear Council Members, Nicholas Butowski, MD Susan M. Chang, MD Jennifer L. Clarke, MD, MPH Sabine Mueller, MD, PhD I enthusiastically write to support this proposal for the new degree, Doctor of Theodore Nicolaides, MD Michael D. Prados, MD Philosophy (PhD) in Rehabilitation Science within the Department of Physical Neuropsychology Therapy and Rehabilitation Science at the University of California, San Caroline Belkoura, PhD Francisco. This degree is an interdisciplinary endeavor that will offer new Neurospinal Disorders Christopher P. Ames, MD Dean Chou, MD coursework in musculoskeletal biomechanics and clinically-informed Sanjay Dhall, MD Praveen V. Mummaneni, MD neuroscience, while also providing students access to coursework and Philip R. Weinstein, MD professional colleagues in a variety of graduate programs, such as Pediatric Neurosurgery Kurtis Auguste, MD Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering, by Nalin Gupta, MD, PhD Corey Raffel MD, PhD allowing them to choose a curriculum tailored to their needs. The PhD in Ronald Shallat, MD Peter Sun, MD Rehabilitation Science program draws on the existing partnership between

Peripheral Nerve Disorders UCSF and San Francisco State University, and will provide students with the Michel Kliot, MD

Pituitary Endocrinology necessary skills to become leaders and researchers in rehabilitation within Lewis S. Blevins Jr., MD the dynamic new American health care system. Functional Neurosurgery Edward F. Chang, MD Paul S. Larson, MD Daniel A. Lim, MD, PhD As the Chair of the Department of Neurological Surgery, I see the potential for Philip A. Starr, MD, PhD Phiroz E. Tarapore, MD collaboration between our faculty and the proposed PhD in Rehabilitation Community Extension Tarun Arora, MD, Director Science. The goals of this program are in line with the vision and mission of Keith Quattrocchi, MD, PhD Archimedes Ramirez, MD UCSF, and this new program offers opportunity for collaboration across the Jeffrey Yablon, MD

University. RESEARCH LABORATORIES Brain Tumor Research Center Arturo Alvarez-Buylla, PhD I am particularly enthusiastic about the benefits and opportunities generated Krystof Bankiewicz, MD, PhD Gabriele Bergers, PhD by identifying coursework that can be shared across graduate programs. I Joseph F. Costello, PhD John Forsayeth, PhD believe this PhD will further advance our working relationships across Rintaro Hashizume MD, PhD Jeanette Hyer, PhD C. David James, PhD programs and help us embrace interprofessional collaboration and Annette M. Molinaro, PhD Arie Perry, MD educational activities. Claudia Petritsch, PhD Joanna Phillips, MD, PhD Russell O. Pieper, PhD John Wiencke, PhD The development of the PhD in Rehabilitation Science program is timely and Margaret Wrensch, PhD Shichun Zheng, MD helps UCSF address the growing need for qualified faculty in Physical Kyle Walsh, PhD

Brain and Spinal Injury Center Therapy programs and investigators who can contribute to the body of Michael S. Beattie, PhD Jacqueline C. Bresnahan, PhD research related to rehabilitation. Adam R. Ferguson, PhD Linda J. Noble-Haeusslein, PhD

Cerebrovascular Research NEUROSURGERY/NEURO-ONCOLOGY CLINICS ADMINISTRATIVE OFFICE RESEARCH LABORATORIES COMMUNITY EXTENSION Arnau Benet, MD 400 Parnassus Avenue, 8th Floor 505 Parnassus Avenue 1450 Third Street, Mission Bay Napa Neurosurgery Clinic Jialing Liu, PhD Box 0350 (Neurosurgery) Room M-779, Box 0112 Helen Diller Family Cancer Research Building Phone: 707/554-8273 S. Scott Panter, PhD Box 0372 (Neuro-oncology) San Francisco, CA 94143 Mail Code 0520; P.O. Box 5859001 Fax: 707/642-8273 San Francisco, CA 94143 Phone: 415/353-3933 San Francisco, CA 94158-9001 Marin Neurosurgery Clinic Epilepsy Research Phone: 415/353-7500 (Neurosurgery) Fax: 415/353-3910 Phone: 415/476-2876 Phone: 415/514-6868 Scott C. Baraban, PhD 415/353-2966 (Neuro-oncology) Fax: 415/514-9792 Fax: 415/461-4398 Fax: 415/353-2889 415/353-2167 February 3, 2014 Page 2

I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Mitchel S. Berger, MD, FACS, FAANS Berthold and Belle N. Guggenhime Professor Chairman, Department of Neurological Surgery Director, Brain Tumor Research Center University of California, San Francisco

University of California San Francisco

Department of Neurology School of Medicine

Stephen L. Hauser, MD January 31, 2014 Chair, Department of Neurology Sandler Neurosciences Center 675 Nelson Rising Lane UCSF Graduate Council San Francisco, CA 94158 Academic Senate Office UCSF Box 0764, MUE Room 253 tel: 415/476-9211 San Francisco, CA 94143 [email protected]

Dear Council Members,

I write with great enthusiasm, and no reservations whatsoever, in support of this proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. This degree is an interdisciplinary endeavor that will offer new coursework in musculoskeletal biomechanics and clinically-informed neuroscience, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, Neuroscience, and Bioengineering, by allowing them to choose a curriculum tailored to their needs. The PhD in Rehabilitation Science program draws on the existing partnership between UCSF and San Francisco State University, and will provide students with the necessary skills to become leaders and researchers in rehabilitation within the dynamic new American health care system.

As the Chair of the Department of Neurology, I see extraordinary potential for tight-knit collaboration between our faculty and the proposed PhD in Rehabilitation Science. Developing effective ways to protect residual function, and restore lost capabilities for terrible brain diseases, is the next frontier for the clinical neurosciences. Advances in imaging, bioengineering, stem cell biology, as well as experimental therapeutics set the stage for truly dramatic advances in our lifetimes. We have many outstanding faculty who will be natural partners and mentors for the new program; they include Gary Abrams, Karunesh Ganguly, Wade Smith, Bruce Miller, and Adam Gazzaley, among others. Thus, the goals of this program are absolutely in line with the vision and mission of our department, and this new program offers opportunity for collaboration across the University.

I’m particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across graduate programs. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

The development of the PhD in Rehabilitation Science program is timely and helps UCSF address the growing need for qualified faculty in Physical Therapy programs and investigators who can contribute to the body of research related to rehabilitation.

I hope that this proposal for the PhD in Rehabilitation Science degree will be favorably reviewed and I offer my enthusiastic support for its development.

Sincerely,

Stephen L. Hauser, M.D. Robert A. Fishman Distinguished Professor and Chair

University of California San Francisco

Department of Orthopaedic Surgery January 28, 2014

UCSf Graduate Council

Thomas Parker Vall, M.D. Academic Senate Office Professor and Chairman UCSF Box 0764, MUE Room 253 David S. Bradford, M.D. Professor and Chairman - Emeritus , San Francisco, CA 94143

Arthritis and Joint Replacement Kevin Bozic, M.D. Hany E. Jergesen, M.D. Dear Council Members, Erik Hansen, M.D. Alfred Kuo, M.D. Michael D. Ries, M.D. I enthusiastically write to support this proposal for the new degree, Doctor of Philosophy Thomas Parker Vail, M.D. (PhD) in Rehabilitation Science within the Department of Physical Therapy and Rehabilitation ArthritisfCartiiage Injury Science at the University of California, San Francisco. This degree is an interdisciplinary Hubert Kim. M.D., Ph.D. endeavor that will offer new coursework in musculoskeletal biomechanics and clinical/y­ Foot & Ankle R. Richard Coughlin, M.D. informed neuroscience, while also providing students access to coursework and professional Landrus Pfeffinger, M.D. colleagues in a variety of graduate programs, such as Epidemiology, Biomedical Sciences, Kirstina Olson, M.D. Neuroscience, and Bioengineering, by allowing them to choose a curriculum tailored to their Hand and Upper Extremity Mohana Amlrtharajah, M.D. needs. The PhD in Rehabilitation Science program draws on the existing partnership lisa L. Latlanza, M.D. between UCSF and San francisco State University, and will provide students with the Scott Hansen, M.D. Mathias Masem, M.D. necessary skills to become leaders and researchers in rehabilitation within the dynamic new

Oncology American health care system. Richard O'Donnell, M.D. Orthotics and Prosthetics As the Chair of the Department of Orthopaedic Surgery, I see the potential for collaboration Matthew Garibaldi, C.P.D. between our faculty and the proposed PhD in Rehabilitation Science. The goals of this Pediatric Orthopaedics Ellana Delgado, M.D. program are in line with the vision and mission of UCSF, and this new program offers Mohammad Diab, M.D. opportunity for collaboration across the University. Coleen Sabatini, M.D. Aenor Sawyer, M.D.

Physical Medicine & Rehabilitation ; I am particularly enthusiastic about the benefits and opportunities generated by identifying Slbe! Demir-Deviren, M.D. ' coursework that can be shared across graduate programs. I believe this PhD will further Masato Nagao, M.D. Usa Pascual, M.D. advance our working relationships across programs and help us embrace interprofessional

Podiatry collaboration and educational activities. Monara Dinl, DPM Diana Werner, DPM The development of the PhD in Rehabilitation Science program is timely and helps UCSF Sports Medicine Christina Allen, M.D. address the growing need for qualified faculty in Physical Therapy programs and W. Dilworth Cannon, M,D. investigators who can contribute to the body of research related to rehabilitation. Alexis Dang, M.D, Brian Feeley, M.D. Anthony Luke, M.D. I sincerely hope this proposal for the PhD in Rehabilitation Science degree will be favorably C. Benjamin Ma, M.D, Carlin Senter, M.D. reviewed and I offer my enthusiastic support for the development of this program. I look

Research forward to continued collaboration with this degree program in the future. Tamara Alliston, Ph.D. Xuhui liu, M,D, Jeffrey Lotz, Ph,D, Sincerely, Ralph Marcuclo, Ph.D, Richard Schneider. Ph,D.

Spinal Disorders Sigurd Berven, M.D. Shane Burch, M,D, Vedat Devlren, M.D, Serena S. Hu, M.D. Thomas P. Vail, MD Bobby K-B Tay, M.D. Professor and Chairman Trauma Department of Orthopaedic Surgery Utku Kandemlr, M.D. Melr Marmor, M.D. Arnlr Matltyahu, M.D. R. Trigg McClellan, M,D. Eric Meinberg, M.D, UCSF MEDICAL CENTER UCSF ORTHOPAEDIC INSl1TUTE MT, ZION MEDICAL CENTER SAN FRANCISCO GENERAL HOSPITAL Theodore MIclau. M,D. 500 Pamassus Avenue (MU-320W) 1500 Owens Street 1600 Divisadero Street, 4th Floor 1001 Potrero Avenue, (3A36) San Francisco, CA 94143-0728 San FranCiSCO, CA 94158 San FranCiSCO, CA 94115 Saam Morshed, M,D" Ph,D, San FranCisco, CA 94110-0842 tel: 415/476-1166 tel: 4151353-2808 tel: 4151885-3800 tel: 415/206-8812 Murat Pekmezci, M,D, fax: 4151476-1304 fax: 4151885-9643 fax: 4151353-7299 fax: 415/647-3733 Nicole Strauss, M.D, www.orthosurg.ucsf,edu www.orthotrauma.com UCSF/SFSU GRADUATE PROGRAM SAN FRANCISCO IN PHYSICAL THERAPY 1600 Holloway Avenue STATE UNIVERSITY San Francisco, CA 94132 phone: 415/338-2001 fax: 415/338-0907 e-mail: [email protected] UCSF Graduate Council web: www.pt.sfsu.edu Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

We are writing to support the proposal for the new degree, Doctor of Philosophy (PhD) in Rehabilitation Science housed within the Department of Physical Therapy and Rehabilitation Science at the University of California, San Francisco. The Ph .D. in Rehabilitation Science, offered in collaboration with faculty from the Department of Physical Therapy and Clinical Laboratory Science at San Francisco State University, will address the growing need for research faculty in physical therapy programs and increase the number of investigators who can contribute to the body of research in the interdisciplinary field of rehabilitation.

Drawing on the strengths of both universities, this bold step to offer a doctorate in Rehabilitation Science will increase the opportunity for extramural support gained by faculty at both universities. PhD students will also be able to participate in laboratory rotations and mentoring with faculty at SFSU in addition to UCSF. Therefore, we support the PhD proposal and continued collaboration between SFSU and UCSF.

Sincerely, '-- . {A~~ ;J~

Lind :{a~e:, PT, PhD Professor and Chair Department of Physical Therapy and Clinical Laboratory Science San Francisco State University

Dean, Graduate Studies San Francisco State University

THE CALIFORNIA STATE UNIVERSITY: Bakersfield, Channel Islands, Chico, Dominguez Hills, East Bay, Fresno, Fullerton, Humboldt, Long Beach. Los Angeles, Maritime Academy, Monterey Bay, Northridge, Pomona, Sacramento, San Bernardino, San Diego, San Francisco, San Jose, San Luis Obispo, San Marcos, Sonoma, Stanislaus Letters of Support from Basic Science Department Chairs and Basic Science Program Directors

Basic Science Department Chairs

From: David Julius, PhD Professor and Chair, Department of Physiology Date: January 26, 2014 1:35 PM Hello Kim, Yes, I am in support of your plans for this new graduate program in Rehabilitation Science. Very best, DJ From: Grae Davis, PhD Professor and Chair, Department of Biochemistry and Biophysics Date: January 26, 2014 6:40 PM Hi Kim- I am supportive. Best of luck with this. Cheers Grae From: Kathy Giacomini, PhD Professor and Chair, Department of Bioengineering and Therapeutic Sciences Date: January 27, 2014 7:21 AM Hi Kim, I also support your proposed PhD in Rehabilitation Science and see potential synergies with our joint UC Berkeley-UCSF Bioengineering PhD program. Kathy From: Allan Basbaum, PhD Professor and Chair, Department of Anatomy Date: January 26, 2014, 10:03 PM Dear Kim, I am very happy to support the proposal. Seems to me that greater reference to the strength of UCSF in preclinical and clinical studies of pain might be valuable. I noted that there was only one reference to pain (in the context of arthritis). Given that the proposed program indicates that fundamental studies (molecular, etc.) are envisioned, perhaps the pain faculty hear (in addition to Christine Miaskowski) can be helpful. Good look with the proposal. Regards, Allan

From: Lewis Lanier, PhD Professor and Chair, Department of Microbiology and Immunology Date: January 27, 2014 9:39 AM Sounds like a great program - happy to support. Lewis From: Kevan Shokat, PhD Professor and Chair, Department of Cellular and Molecular Pharmacology Date: January 27, 2014 9:25 AM Dear Kim, Great work on getting the program off the ground. I'm in support also. Best, Kevan

Basic Science Graduate Program Directors

From: Matt Jacobson, PhD Professor and Vice Chair, Pharmaceutical Chemistry; Director, Biophysics Graduate Program Date: January 25, 2014 8:40 PM I am happy to provide my support, but it would be good, at some point, to discuss a little more your vision for this program, including opportunities to connect to the basic sciences. -- Matt From: Charles Craik, PhD Professor, Pharmaceutical Chemistry; Director, Chemistry and Chemical Biology Graduate Program Date: January 26, 2014 12:26 AM Hi Kim, I am more than happy to provide my support. I like the proposal you outline. At some point it would be good to see the faculty that you will have in the program, how you choose them and how you plan to support the students in their labs. We have one quarter of teaching until they pass their qualifying exam in their second year and then they can do more teaching after that if they are interested. I expect these will be questions you get asked at graduate council. Hope it goes well. Best, Charly From: Patricia Babbitt, PhD Professor, Bioengineering and Therapeutic Sciences; Director, Biological and Medical Informatics Program Date: January 26, 2014 12:08 PM Hi Kim, I also am happy to provide my support. If you want to talk at some point about how Bioinformatics might fit into your program, I'd be happy to meet with you. I second Charly's points as well. Patsy

From: David Morgan, PhD Professor, Physiology; Director, TETRAD Graduate Programs Date: January 26, 2014 12:39 PM Hi Kim: I am also happy to provide my support, and I look forward to hearing more about the program. All the best, Dave From: Jeremy Reiter, PhD Associate Professor, Biochemistry and Biophysics; Director, Developmental and Stem Cell Biology Graduate Program Date: January 26, 2014 2:07 PM Hi Kim, Likewise, I'm happy to support your new program and eager to learn more. While stem cell therapies remain, outside of blood and skin, largely a fantasy, there might be some synergy between DSCB and Rehabilitation Science in years to come. Best, Jeremy From: Deanna Kroetz, PhD Professor, Bioengineering and Therapeutic Sciences; Director, Pharmaceutical Sciences and Pharmacogenomics Graduate Program Date: February 2, 2014 11:06 PM Hi Kim, Sorry, was out when this came and still playing catch up. PSPG is in support of this new program and I hope we can find ways to interact. Best, Deanna