3 Timetable for Development of the Proposed Phd Program, Including Enrollment Projections

PROPOSAL FOR A PROGRAM OF GRADUATE STUDIES IN GLOBAL HEALTH SCIENCES LEADING TO THE PHD DEGREE

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO GLOBAL HEALTH SCIENCES (GHS)

September 24, 2014

PhD Program Director:

Sally Rankin, RN, PhD, FAAN Faculty Associate Global Health Sciences Professor Emeritus, School of Nursing [email protected]

GHS Directors:

Jaime Sepúlveda, MD, MPH, MSc, DrSc Executive Director Global Health Sciences [email protected]

Molly Cooke, MD, MACP Education Director Global Health Sciences Professor, Department of Medicine [email protected]

Colin Boyle, MBA Deputy Director Global Health Sciences [email protected]

Lead Administrative Staff:

Karen Nelson, MA Special Projects Global Health Sciences [email protected]

Table of Contents

SECTION 1. INTRODUCTION ...... 4 1.1 Aims and Objectives ...... 4 1.2 Historical Development of the Field ...... 5 1.2.1 UCSF Global Health Sciences ...... 7 1.3 Timetable for Development of the Proposed PhD Program, Including Enrollment Projections ...... 11 1.4 Relationship of the Proposed Program to Existing Programs on Campus and to Campus Academic Plan ...... 12 1.5 Interrelationship of the Program with Other University of California Institutions ...... 14 1.6 Administration and Governance of the Program ...... 15 1.7 Plan for the Evaluation of the Program ...... 16 SECTION 2. PROGRAM ...... 16 2.1 Candidates’ Preparation, Admission Requirements, and Process ...... 16 2.2 Language Requirements ...... 17 2.3 Program of Study ...... 17 2.3.1 Specific Fields of Emphasis ...... 17 2.3.2 Unit Requirements ...... 20 2.3.3 Required and Recommended Courses including Teaching Requirement ...... 20 2.3.4 Licensure ...... 23 2.4 Field Examinations ...... 23 2.5 Qualifying Examinations ...... 23 2.6 Dissertation ...... 24 2.7 Final Examination ...... 25 2.8 Explanation of Special Requirements (if applicable) ...... 25 2.9 Relationship of masters and doctoral programs ...... 25 2.10 Special Preparation for Careers in Teaching ...... 26 2.11 Sample Program ...... 26 2.12 Normative Time for Matriculation to Degree ...... 27 SECTION 3. PROJECTED NEED ...... 28 3.1 Student Demand for the Program ...... 28 3.2 Opportunities for Placements of Graduates ...... 32 3.3 Importance to the Discipline...... 32 3.4 Ways the Program Will Meet the Needs of Society ...... 33 3.5 Relationship of the Program to Research and/or Professional Interests of the Faculty ....33

3.6 Program Differentiation ...... 35 SECTION 4. FACULTY ...... 36 4.1 List of Faculty Members, Ranks, and Highest Degrees...... 36 4.2 Commitment Letters from Faculty ...... 38 4.3 Letters of Departmental, School, and Program Support ...... 38 SECTION 5. COURSES ...... 38 5.1 Description of Present and Proposed New Courses ...... 38 SECTION 6. RESOURCE REQUIREMENTS...... 42 6.1 FTE Faculty and Staff Organizational Chart ...... 42 6.2 Library Acquisitions ...... 43 6.3 Computing Costs ...... 43 6.4 Equipment ...... 43 6.5 Space and Other Capital Facilities ...... 43 6.6 Other Operating Costs ...... 43 SECTION 7. GRADUATE STUDENT SUPPORT ...... 44 SECTION 8. CHANGES IN SENATE REGULATIONS ...... 45 APPENDICES ...... 46

SECTION 1. INTRODUCTION

1.1 Aims and Objectives

UCSF Global Health Sciences (GHS) is dedicated to improving health and reducing the burden of disease in the world’s most vulnerable populations. GHS integrates UCSF’s expertise in the health, social, population and biological sciences, and focuses that expertise on pressing issues in global health. Founded in 2003 by former Dean of the School of Medicine and UCSF Chancellor, Haile Debas, GHS is composed of an innovative team of educators, researchers, and healthcare professionals working in California and around the world to train global health leaders and build sustainable solutions to improve health and eliminate disease.1

Building on the strength of its MS degree in Global Health Sciences, UCSF seeks to establish the first University of California PhD degree in Global Health Sciences. The goal of the program is to prepare doctoral level graduates competent to apply research methods to explore and solve global health problems within academia and bilateral, multilateral, and non-governmental organizations.

As the Institute of Medicine observes, “Health knows no borders… global health is aimed at advancing the health of populations worldwide. It includes, among other subjects, disease and disability in developing countries, existing and emergent threats to international health, and U.S. international health policy.” Global health focuses on transdisciplinary approaches2 to understanding and addressing health inequities wherever they occur. While many/most students will consider health problems occurring in low- and middle-income countries, the setting is not an element of the definition of the field. The science and substantive knowledge base of global health is growing, and our proposed rigorous and scholarly doctoral program will accelerate the development of the field.

Our specific aims and objectives are:

1. To establish a premier PhD program that will guide and contribute to the science and knowledge base of the emerging discipline of global health. 2. To leverage the expertise of GHS faculty and faculty from the four UCSF health science schools and the Graduate Division involved in global health research and education. 3. To provide a preeminent program for health sciences professionals to gain the research skills and knowledge base for careers in global health. 4. To develop a PhD program with four concentrations representing areas in which UCSF Global Health Sciences has major strengths and active research programs. Each concentration is a combination of coursework and research training:

a. Clinical concentration – focus areas include non-communicable/ neglected/ tropical/ infectious diseases and maternal/child health.

1 In this proposal the term global health connotes the field, whereas the term global health sciences refers to our MS and PhD programs, and our proposed School. 2 The concept of transdisciplinary science is discussed later in this document, but a useful definition is, “transdisciplinary research aims to integrate knowledge from various scientific and societal bodies of knowledge” such that it will yield qualitatively different results than interdisciplinary research (Popa F, et al., A pragmatist approach to transdisciplinarity in sustainability research: From complex systems theory to reflexive science. Futures (2014), dx.doi.org/10.1016/j.futures.2014.02.002). 4

b. Policy concentration – public health policy in a globalized world. c. Health systems concentration – workforce capacity and health systems strengthening. d. Social and behavioral science concentration – examples include theories related to and derived from health economics, law, medical anthropology, and medical sociology:

This unique program of study will allow graduates to make significant contributions to the multidisciplinary field of global health, expand UCSF training opportunities, and complement, but not compete with, existing highly ranked UCSF doctoral programs.

1.2 Historical Development of the Field

In a frequently cited Lancet article from 2009, members of the Consortium of Universities for Global Health reflected on the origins of global health and developed a definition (Koplan, Bond, Merson et al, 2009). Pointing out that the foundations of global health are in public and international health, they also recognize the earlier influence of hygiene and tropical medicine. Public health has a long and respected history, having emerged in its modern form in the mid- nineteenth century in the US, England, and Europe. Key to public health has been its emphasis on: 1) decision-making based on vital statistics, surveillance and outbreak data, and laboratory science; 2) focus on populations rather than individuals; 3) goal of social justice; 4) emphasis on prevention rather than curative care (Farr, Chadwick, Virchow et al, as cited in The Lancet 2009). International health has largely concentrated on health work abroad, especially in lower- and middle-income countries, where it has been focused on infectious and tropical diseases, water and sanitation, malnutrition, and maternal and child health; global health displays its relationship to international health in its concern with the same issues. Similarly, public, international, and global health share many of the same characteristics, principles, research methods, and interdisciplinary approaches.

In both the social and natural sciences, philosophical shifts have played an important role in the ascendance and decline of fields, that is, their historical development.3 For example, environmental science is an academic field that came into existence in the 1960’s, not as a result of any particular methodological innovation or scientific advance but spurred by Rachel Carson’s The Silent Spring. In the same way, a recent shift in philosophy and attitudes in the global health community has resulted in a definition of global health that underlies the basis of our proposed program:

Global health is an area for study, research and practice that places a priority on improving health and achieving equity in health for all people worldwide. Global health emphasizes transnational health issues, determinants and solutions; involves many disciplines within and beyond the health sciences and promotes interdisciplinary [transdisciplinary] collaboration; and is a synthesis of population-based prevention with individual-level clinical care. (Koplan, J P, Bond, T C, Merson, M H, et al. (2009).

The recognition that we live in a globalized world in which we have an interest in the health of others—because everyone’s health affects our health, our security, and our moral standing—is motivating the development of the field of global health.

3 Kuhn, Thomas (1962). The structure of scientific revolutions. University of Chicago Press. 5

The field of global health is transdisciplinary and considers health from perspectives ranging from biological to environmental to cultural, and health improvement approaches from personal to political. The expertise that defines global health is 1) a comprehensive understanding of the factors that bear on the health of individuals, communities, and populations; 2) command of a diverse array of analytic approaches in exploring significant problems in health worldwide; and 3) skill in transdisciplinary work, research, practice and/or education, to address health inequities. The scale and complexity of the problems in global health require a synthetic, transdisciplinary approach, that is, skill and versatility in the application of a plethora of scientific theories, concepts, approaches, and methods.

Global health’s emphasis on knowledge development, practice, and research forms the basis for our proposal for a PhD program that is academically challenging, requires original research using appropriate theoretical approaches and research methods, builds the science of global health, and prepares graduates for an academic career in a level-one research institution. A PhD in global health provides greater depth in research methods and better prepares academicians for careers in research than the DrPH, the professional practice degree in public health. Furthermore, lacking a School of Public Health, UCSF cannot offer a DrPH.

Global health is emerging as a vital field of expertise to improve the health of populations in both industrialized and developing nations. As such, it has taken center stage in transnational public health efforts and funding, and has galvanized academic institutions, their faculty, and students to join forces with the goal of improved health for all. At least eight factors can be cited for the growing importance and popularity of global health:

Globalization: Globalization is transforming the world order in trade, commerce, and information flow, promoting regional economic integration, creating new partnerships between health professionals across national borders, and altering global disease patterns. As labor-intensive manufacturing and service industries move increasingly to low- and middle-income countries (LMICs), and individuals and their families emigrate to pursue work and a better standard of living, a globalized workforce is emerging. The preparation of this workforce to address transnational disease burdens and health needs demands a rigorous and intentional approach.

The Millennium Development Goals (MDG): Established in 2000 following the United Nations (UN) Millennium Summit (www.un.org/millenniumgoals/bkgd.html), these goals are endorsed by 189 nations as a path to alleviate extreme poverty and multiple deprivations worldwide (e.g., goal 1 – eradicate extreme poverty and hunger, goal 2 – achieve universal primary education, goal 6 – combat HIV/AIDS, malaria and other diseases). Although it was intended that the MDGs be achieved by 2015, the reality is that goal achievement will be an ongoing process, and the UN is currently formulating a successor set of Sustainable Development Goals (SDGs, www.sustainabledevelopment.un.org) for the post-2015 era. The SDGs are likely to be closely linked to the previous MDGs, with a focus on sustainable development and non-communicable diseases. The goals should continue to serve as a foundation for global health efforts and will require a long-term, collaborative commitment of well-trained global health professionals.

Health Equity and Social Justice: Recognition that food, potable water, health care resources, and health itself are inequitably distributed has stimulated concern among faculty and students in academic institutions and public health practitioners across the globe. Students, in particular, contribute idealism and seek more agency and skills to move the world toward equity.

Health Diplomacy: This new branch of “soft power” is broadly defined as the application of targeted global public health efforts to advance bilateral and multilateral government-to- government relations, particularly in high-conflict areas and low-income countries. Health diplomacy melds public health, economics, management, law, and international affairs, and can be considered a marriage of diplomatic and global health efforts to improve health.

Global Health Policy: The health of the world’s population is related to the health delivery policies determined by national, bilateral, and multilateral organizations. However, academic researchers are often naïve about how policy is formulated and too often policy makers move forward with policies that are inadequately empirically informed. Global health policy should be founded on solid evidence that can inform policy making and eventually implementation.

Emerging/ Tropical/ Infectious Diseases: The HIV/AIDS pandemic continues to take a heavy human toll. It has devastated many countries in sub-Saharan Africa, depleting their workforces, economies, and social and cultural fabric, while simultaneously threatening their national security. The12 million children in Sub-Saharan Africa who are “AIDS orphans” urgently require the world’s attention. The HIV pandemic is also a major health problem in India, Southeast Asia, and China, and has become an increasing public health problem in Latin America. Migration plays a central role in HIV transmission, as it does with many other health challenges; research is needed to promote primary and secondary prevention among migrant populations.

Malaria is the major cause of death in children under five in Sub-Saharan Africa and is a major focus of research at GHS. Dengue and Chagas disease are among the 17 neglected tropical diseases enumerated by WHO and are a focus of study by University of California scientists. The National Institute of Infectious and Allergic Diseases defines emerging diseases as those pathogens identified in the last two decades; examples include new strains of human herpes virus and putative zoonotic pathogens such as the Middle Eastern Respiratory Syndrome (MERS) virus. Re-emerging diseases include tuberculosis, enterovirus 71, Clostridium difficile, mumps virus, Group A Streptococcus, and methicillin-resistant Staphylococcus aureus.

Non-communicable Diseases: Research on the global burden of disease indicates that chronic disease conditions and their risk factors figure prominently in disease morbidity and mortality in developing countries. Heart disease, diabetes, hypertension, cerebrovascular disease, obesity, and traffic accidents now account for about 50 percent of the global disease burden. Mental illness is projected to soon top the list of NCDs in the developing world. New, multidisciplinary approaches to prevention, diagnosis, and treatment of non-communicable disease are required. The Framework Convention on Tobacco Control, the first public health treaty negotiated under World Health Organization (WHO) auspices, addresses tobacco use as a leading cause of illness.

Population Control, Maternal and Child Health: Population control measures and access to contraception for women have had measurable salutary effects on global health, but much more needs to be done. The outcomes of uncontrolled population growth include food and water insecurity, environmental degradation, and growing social inequality. Maternal and child mortality rates, still alarmingly high in many countries, are linked to limited family planning.

1.2.1 UCSF Global Health Sciences

UCSF Global Health Sciences was established in 2003 to provide institutional leadership for the emerging field of global health at UCSF. The creation of GHS underscores UCSF’s commitment

to global health and to the care of vulnerable populations at home and throughout the world. Since September 2011, GHS has been under the leadership of Jaime Sepúlveda, who followed the tenures of Sir Richard Feachem and Haile Debas, former Executive Directors. In its ten-year history, Global Health Sciences has experienced rapid expansion, with about 200 faculty and staff working across its programs, the inclusion of The Institute of Global Health, an Organized Research Unit, and a growing number of educational, research, and action-oriented projects underway in dozens of countries.

A GHS organizational chart and brief descriptions of GHS units and programs that have expertise in both research and teaching follow below. These units, as well as the PhD Graduate Group, will meet the pedagogical objectives of the program and provide research opportunities for students.

GHS Organizational Chart

MS Graduate Group PhD Graduate Group

The GHS Education and Training Group has trained 761 participants since formal GHS education programs began in 2005: 163 in the MS degree program; 82 in the Pathway to Discovery in Global Health program; 201 in the Clinical Scholars program; and 317 in Complex Humanitarian Emergency Training. Molly Cooke became the education director in 2012.

The Global Health Sciences MS degree program has completed its sixth year. Graduates of the one-year program are prepared for leadership careers in global health policy, health care, research, and international development. Approximately half of the graduates are employed in the global/ public health sector, teaching and/or conducting research in academia, and working at NGOs and in other public and non-profit areas. The remaining alumni are enrolled in advanced academic or professional degree programs and residency programs.

The MS program, initially under the leadership of John Ziegler, successfully completed its first five-year Academic Program Review in May 2013. External reviewers noted the outstanding academic quality of the program, diverse and formative experiential practica, strong and committed faculty, and high achieving students.

The Pathway to Discovery in Global Health program serves UCSF health professions students who desire a concentration in global health through coursework and clinical or research experience with an underserved population. In 2013, the program offered an MD with Distinction in Global Health for the first time.

The Clinical Scholars program is a training track for UCSF graduate healthcare professionals (UCSF residents, scholars, fellows, and graduate students) from the Schools of Medicine, Nursing, Dentistry, Pharmacy, and the Graduate Division, who wish to formally incorporate global health into their professional careers.

GHS provides supports an annual Complex Humanitarian Emergency Leadership Training two- day program that simulates a refugee crisis (e.g. the border of Syria and Turkey). Under the guidance and supervision of experienced professionals, participants perform a rapid assessment and develop plans to meet the needs of the simulated refugee population. The event challenges trainees to consider water sanitation concerns, learn sampling and communication skills, and address emergency medical needs, providing simulated on-the- ground experience.

Other entities with a largely educational function include the International Traineeships in AIDS Prevention Studies (I-TAPS). A joint program between GHS and the UCSF Center for AIDS Prevention Studies (CAPS), I-TAPS offers short-term post-doctoral research training for health professionals from low- and middle-income countries. Now in its 25th year, I-TAPS has trained more than 241 alumni from 46 countries, who have gone on to become leaders at their home universities, Ministries of Health, National Aids Control Programs, and United Nations Agencies. Collaborations between GHS doctoral students and I-TAPS scholars are planned.

The MS Graduate Group in Global Health Sciences, chaired by Craig Cohen, was established in 2008 as the degree-granting arm of GHS education programs, and includes faculty from across the four schools and members from other UC campuses. GHS has also formed a PhD Graduate Group and developed by-laws that are included in Appendix 2.

In addition to education programs, GHS is home to three groups working broadly in the area of implementation and systems strengthening. Two of these groups have content experts who currently teach in the Master’s program, and all three will be involved in teaching in the PhD program. Projects within the Global Health Group (GHG) and the Prevention and Public Health Group (PPGH) have served as the platform for MS students’ capstone work. We expect that PPGH, GHG, and the new Center for Implementation Science will likewise afford opportunities for our doctoral students’ research.

The Global Health Group (GHG) bridges the gap between evidence, policy, and implementation to stimulate practical international and local action to solve critical health challenges. Its team conducts targeted research and advocacy on behalf of three signature initiatives—the Malaria Elimination Initiative, the Private Sector Healthcare Initiative, and the Evidence to Policy Initiative—expanding global understanding and engaging a growing network of partners to take forward new approaches. Through its work, policymakers, funders, and country leaders gain access to new and relevant data, recommendations, and tools—and make informed decisions about important next steps in strategy, funding, and implementation.

The GHG is directed by Sir Richard Feachem, the Founding Executive Director of the Global Fund to Fight AIDS, TB and Malaria, and former Under Secretary General of the United Nations.

GHG collaborates closely with the WHO, the Bill & Melinda Gates Foundation, bilateral donors, and a number of other policy, finance, and academic groups around the world. The GHG has made significant contributions to: the advancement of malaria elimination; enhancing the role of the private sector in health systems strengthening; and synthesizing evidence to inform global health policy broadly.

The Prevention and Public Health Group (PPHG) works to strengthen public health systems and to prevent and control high-burden infectious and tropical diseases worldwide. PPHG’s 70 affiliated faculty and senior staff deploy their expertise and field experience around the world to conduct research, inform public health and clinical policy, train local professionals, and build capacity. PPHG leverages strengths in epidemiologic research methods, public health surveillance, monitoring and evaluation, systematic reviews and guidelines development, training, technical assistance, and mentoring.

Directed by George Rutherford, PPHG is supported by the US Centers for Disease Control and Prevention, the National Institutes of Health, Joint United Nations Program on HIV/AIDS, The President’s Emergency Program for AIDS Relief (PEPFAR) and the WHO, and works with academic, government, private, and community partners in more than 40 countries. PPHG also conducts systematic reviews of interventions and, as host of the Cochrane Collaboration’s HIV/AIDS Group, works in close collaboration with the WHO to develop clinical prevention and treatment guidelines, especially in the areas of HIV and HIV-related opportunistic infections.

The newest group is the Center for Implementation Sciences led by Eric Goosby, a UCSF- trained physician who, in November 2013, stepped down from his role as the nation’s Global AIDS Ambassador and head of PEPFAR. Dr. Goosby has returned to his alma mater and joined GHS to develop and lead a new center on Implementation Sciences.

Global Health Sciences also houses large research and applied research programs focused on three conditions or clusters of conditions of global importance: AIDS, neglected tropical illnesses, and preterm birth. GHS PhD students who choose to concentrate on a particular condition of global importance will find ample opportunities in association with these initiatives.

AIDS Research Institute (ARI) coordinates and integrates all AIDS research activities at UCSF. The ARI stimulates innovation and supports interdisciplinary collaboration aimed at all aspects of the epidemic domestically and around the world. Bringing together hundreds of scientists and more than 50 programs from throughout the university and affiliated labs and institutions, and working in close collaboration with affected communities, the ARI is one of the premier AIDS research entities in the world. ARI was formerly directed by John Greenspan, Associate Dean of Global Oral Health in the School of Dentistry, and has been under the leadership of Paul Volberding since 2012.

Fighting Infections through Research, Science and Technology (FIRST) is a partnership between the Carlos Slim Health Initiative (ICSS), the Bill & Melinda Gates Foundation, and UCSF that seeks to reduce the burden of infectious tropical diseases in neglected populations across Mesoamerica. The initiative comprises eight projects in the current portfolio; GHS serves as the prime grantee with Executive Director Jaime Sepúlveda as the principal investigator. GHS works with 15 different research partners—including UC Berkeley, San Diego, and Santa Cruz—on projects ranging from drug discovery to blood bank screening processes to innovative community-based vector control models. By bringing leading-edge research and new

technologies to bear on preventable infections, FIRST will significantly advance health and reduce inequities in the region’s eight countries.

A new partnership between the Bill & Melinda Gates Foundation and the Benioff Foundation with UCSF, the Preterm Birth Initiative constitutes a unique opportunity to address, over the next ten years, one of the most neglected global health challenges of our time: Preterm Birth (PTB). Prematurity is now the number one cause of neonatal death globally. The PTB Initiative will bring together several existing programs pioneered by UCSF research faculty in collaboration with local investigators at sites in East Africa, Central America, and Southeast Asia, as well as in the Bay Area and will develop new programs strategically designed to explore and address the complex convergence of biological, social and environmental factors that lead to PTB. The planning phase, currently underway, will create an integrated approach to reducing the burden of PTB, involve transdisciplinary teams who will develop research roadmaps for both discovery and implementation of new tools to tackle PTB, and enable the establishment of the project and knowledge management infrastructure to oversee the initiative.

Many other UCSF faculty members work worldwide on health issues of global importance beyond the units housed within GHS. The GHS Office of Research works with faculty and staff in GHS and across the campus to develop new areas of research, supports the creation of resources that facilitate global health research across UCSF, and provides funding and training opportunities for researchers. The GHS Office of Research oversees the Global Research Projects database, the UCSF East Africa office (with the Center for AIDS Research), RAP (Research Allocation Program) funding for basic science and policy research, the Burke Scholars Award program, and the Global Health Economics Consortium (GHECon). Paul Volberding is the Director of the GHS Office of Research.

All of the above research groups and initiatives, as well as those of our Graduate Group members, will constitute the foundation of our doctoral program, including teaching, research rotations, doctoral seminars, and the dissertation. These interdisciplinary and transdisciplinary entities also provide vital experiential opportunities to learn the skills needed to be a leader in the field of global health.

GHS also serves as the administrative home for the UC Global Health Institute (UCGHI). Directed by GHS’s Haile Debas and Thomas Coates from UCLA, the UCGHI is working to build an interdisciplinary, system-wide academic global health program that leverages the expertise of the ten UC campuses. UCSF is also the administrative hub for the NIH Fogarty GloCal Fellowship program through UCGHI, which provides 11-month international training opportunities to post-doctoral and pre-doctoral trainees.

Planning is underway at GHS for a UCSF School of Global Health Sciences; this school would be the first of its kind in the US.

1.3 Timetable for Development of the Proposed PhD Program, Including Enrollment Projections

GHS plans to enroll its first cohort of four students in Fall 2015. Initially, we plan to admit four new students every other year, and transition to an annual admission cycle as soon as additional funding is available. Student support will be derived from individual or group training grants (NIH F31, T32, or other mechanisms from NIH or UCSF intramural training grants), funding from GHS faculty, and philanthropically supported student fellowships. Additional

11 student support from UCSF Global Health Sciences has been guaranteed (see letter from Dr. Jaime Sepulveda). The timeline for development of the program follows.

Campus Review:

• Graduate Division Dean, April 2014 • Graduate Council, May-October 2014 • Academic Senate Coordinating Council, October-November 2014 • UCSF Academic Senate, November 2014 • Chancellor, December 2014

Systemwide Review:

• Coordinating Committee on Graduate Affairs, December-February 2015 • UCOP Provost/ Sr. VP/ President, March 2015

Program Launch:

• Application and admission process, spring quarter 2015 • Program start, fall quarter 2015

1.4 Relationship of the Proposed Program to Existing Programs on Campus and to Campus Academic Plan

International health programs and projects have long been part of the rich training and research portfolio of UCSF faculty; UCSF currently has many projects in scores of countries throughout the world representing all four of its professional schools, the basic science departments, and specialized interdisciplinary units such as the AIDS Research Institute. However, the campus has never had a graduate training track in this field, leaving students who are interested in global health careers to create interdisciplinary training on their own. It is expected that the PhD program in global health sciences will complement existing program activities, as opposed to being competitive with them, by sharing coursework and collaborating on research projects and rotations. As a result of this collaborative approach, the proposed PhD in Global Health Sciences has received wide support at UCSF from the other PhD program directors (see letters of support).

Medical Sciences Training Program (MSTP): The combined MD/PhD program usually enrolls twelve students each year, who complete both degrees in about seven years. Most students are enrolled in biomedical science doctoral programs, with one social science program (medical anthropology) represented. Since a Global Health Sciences PhD program would be an attractive degree option for MD students, GHS will explore partnering with the MSTP in the future and the feasibility of a joint degree program.

PhD Degree Programs in Medical Anthropology, History of Health Sciences, Medical Sociology, Nursing, and Epidemiology and Translational Science: The proposed GHS doctoral program will work closely with these well-established UCSF graduate programs to share coursework, mentors and advisors, and collaborate on mutually relevant research projects. Faculty members in these doctoral programs currently serve as course instructors, advisors, MS capstone

mentors, and as members of the MS GHS Graduate Group. Their contributions will be crucial to the success of the future doctoral program in global health.

The GHS PhD program will be closely affiliated with the Epidemiology and Translational (ETS) Science doctoral program. Dr. Maria Glymour, Director of the ETS PhD Program has contributed to productive discussions about its design. GHS doctoral students will be enrolled in some of the epidemiology and biostatistics coursework taken by the ETS students, including EPI 203, EPI 207, EPI 265, BIOSTAT 208, and BIOSTAT 209. This affiliation will allow development of colleagueship between the ETS and GHS students and will form the basis for later collaboration. We anticipate a balanced partnership based on the sharing of doctoral level courses, courses likely to be of interest to students in the global health concentration in ETS. To underline the distinction between the two programs, graduates of the ETS global health track will be epidemiologists while graduates of the GHS doctoral will be transdisciplinary experts in global health. We will jointly develop a FAQ list that assists applicants in deciding which doctoral program is better suited to their own research interests and capabilities.

School of Dentistry (SOD): The Program in Global Oral Health (dentistry.ucsf.edu/science- research/global-oral-health) in the SOD is led by the Associate Dean for Global Oral Health, John Greenspan and Director Ben Chaffee. Its mission is the improvement of oral and craniofacial health worldwide. The goals for the program include building, strengthening, and coordinating activities in global oral health, developing and supporting programs of excellence, educational, research and community/public service in global oral health and international health, and interacting with UCSF campus, systemwide, and other initiatives in global health. To achieve these goals, the SOD established a successful Oral Global Health Symposium in 2011; the program continues on an annual basis and has tackled challenging oral health problems.

School of Medicine (SOM): A number of the programs falling under the aegis of Global Health Sciences were initiated by faculty in the SOM in response to requests by medical students and residents for programs in global health. Other campus-wide projects such as CTSI, which has a global health component, were originally developed by the SOM. The Division of Hospital Medicine’s Global Health Core and residency program “aims to improve the health of vulnerable populations throughout the world by adapting the unique skill sets of academic hospitalists to resource-poor settings to reduce the burden of disease and realize global health equity.” Because of its size and the level of interest among its learners, the SOM has also provided leadership in a number of campus initiatives, including development of guidelines for student and trainee clinical rotations and safety and security protocols. The SOM has permitted a number of its faculty to teach and mentor students in GHS and continue a very close affiliation.

School of Nursing (SON): As have other professional schools, the SON has experienced burgeoning interest on the part of both master’s and doctoral students who desire global health opportunities either for clinical experiences or research sites for dissertations. As a result, the School initiated a global health minor in 2011, now the most popular minor in the SON. The interest of SON students in global health is evidenced by the fact that they are the second largest group of professional students enrolled in the Clinical Scholars program, Global Health 101, and the Pathways program, following learners from the much larger SOM. We expect that SON masters graduates will apply in substantial numbers for the proposed PhD in global health.

School of Pharmacy (SOP): Aligned with the UCSF tagline “advancing health worldwide™,” the SOP recognizes that their students benefit from international partnerships in teaching, research, and service. Pharmacy students and trainees nationwide are increasingly interested in including

13 global health content in their curricula and to this end the School of Pharmacy is working to provide global health experiences for PharmD students going abroad for advanced pharmacy practice experiences. SOP students also participate in the Global Health Pathways program and one PharmD student recently graduated from the GHS MS program.

Responding to the interest of students in all four professional schools and the Graduate Division, the Global Health Education Council was formed in September 2013. This group of cross-campus stakeholders is chaired by Molly Cooke and provides guidance on the implementation of the PhD program as well as the direction for other global health activities. A second group, the Global Health Education Faculty Interest Group (GHE-FIG) comprises faculty members in all four schools who sponsor learners in clinical settings globally. Both groups are working toward systematization of guidelines for students across all four schools and the Graduate Division, and are making global health student research and clinical and educational experiences safer and more meaningful. Future plans also include the development of joint or concurrent degree programs with the professional schools.

1.5 Interrelationship of the Program with Other University of California Institutions

The UCSF PhD in Global Health Sciences will be the first such stand-alone doctoral program in the UC system. While many institutions provide doctoral level training in related disciplines (see summary below), no campus provides this specific and unique transdisciplinary training and research opportunity. Section 3.1 below details data pertaining to global health academic programs outside of California and the foci of and differences between various programs within California. (See letters of support from other UC institutions.)

UC San Diego: A PhD in Public Health with a concentration in Epidemiology, Health Behavior, or Global Health is offered through the Joint Doctoral Program (JDP) between San Diego State University (SDSU) and the University of California, San Diego (UCSD). The JDP is jointly administered by the Graduate School of Public Health at SDSU and the Department of Family and Preventive Medicine in the School of Medicine. UCSD also offers an undergraduate minor in Global Health, and approval to launch a Global Health major in AY 2015 was announced in May 2014.

UC Davis: The Department of Public Health Sciences (formerly the Department of Epidemiology and Preventive Medicine) is a clinical and research department in the UC Davis School of Medicine. The mission of the Department of Public Health Sciences is to improve the health of people using approaches based in epidemiology, biostatistics, economics, and behavioral science through research, educational programs, clinical programs, public service, and policy development. UC Davis offers PhD programs in Epidemiology, Biostatics, and Pharmacology and Toxicology. The DVM and MPVM degrees are offered through the UCD School of Veterinary Medicine, which includes electives in One Health—a synthetic approach to public health that recognizes the connections between human health, animal health, and the environment.

UC Los Angeles: The Fielding School of Public Health comprises five departments: Biostatistics, Community Health Sciences, Environmental Health Sciences, Epidemiology, and Health Services. Programs leading to the MPH and DrPH degrees emphasize solving public health problems by applying professional disciplinary approaches and methods in professional environments such as local, state, or national public health agencies and health care organizations. Related PhD degrees offered at UCLA include Health and Policy Management,

Epidemiology, Environmental Health, Community Health Sciences, and Biostatistics. The UCLA David Geffen School of Medicine provides a wide array of global health education and training programs that includes coursework, clinical rotations, a speaker series and journal club.

UC Berkeley: The UCB School of Public Health offers a DrPH, which is an interdisciplinary, professional degree that trains doctoral students to be public health leaders and practitioners. The campus also offers PhDs in related public health fields through its Graduate Groups in Biostatistics, Environmental Sciences, Epidemiology, Health Services and Policy Analysis, and Infectious Diseases and Immunology, as well as a joint PhD in Medical Anthropology with UCSF. The School recently announced the formation of a Center for Global Health but has no plans to initiate PhD training in global health. UC Berkeley also offers a Master of Science in Global Health & Environment, an interdisciplinary, campus-wide program based in the School of Public Health that is oriented towards students in environmental sciences.

UC Irvine: The new UCI School of Public Health has recently implemented a PhD program in Public Health with a concentration in Global Health and Disease Prevention.

UC Riverside: The new UCR School of Public Policy plans to offer a master’s degree in Global Health in the fall of 2015, modeled closely on the UCSF MS program but offering a two-year thesis option. It is anticipated that this program, with an expected enrollment of approximately 30 students, will serve as a pipeline for the UCSF doctoral program.

1.6 Administration and Governance of the Program

The PhD will be housed at UCSF Global Health Sciences and governed by the PhD Graduate Group in Global Health Sciences. This is a multidisciplinary and broadly inclusive academic group unique at UCSF in its inclusion of faculty in the basic sciences, health policy, clinical medicine, and clinical research from across the four schools and the Graduate Division, all of whom have expertise in doctoral level training.

The Graduate Group will include an Executive Committee, a Curriculum Committee responsible for the ongoing enhancements of the doctoral curriculum, and an Admissions Committee responsible for the recruitment plan, admissions process, reviewing applications, and selecting candidates for the program. The by-laws of the Graduate Group are available in Appendix 2.

The PhD Program will have a dedicated faculty Program Director and staff Program Coordinator.

The Program Director will:

• Serve on the Executive Committee of the Graduate Group as a voting ex-officio member; • Set the academic standards for the degree program; • Ensure satisfactory student progress toward degree completion; • Ensure appropriate student, faculty, and course evaluation process; • Oversee funding and resources for the program and determine fellowship allocations; • Recruit and appoint faculty course directors, advisors, mentors, GSIs, GSRs; and, • Act as liaison to GHS and campus leadership, the other schools and Graduate Division, and outside organizations.

The PhD staff coordinator will:

• Implement the recruitment, application, and admission process; • Coordinate fellowships and other student support and facilitate grant writing efforts; • Provide staff support for the business and activities of the Graduate Group; • Maintain student and alumni tracking system; • Serve as liaison to central campus student services; • Coordinate course scheduling, evaluation process, digital enhancements to courses, student orientation, retreats;

1.7 Plan for the Evaluation of the Program

We will take a comprehensive, multi-method approach to the assessment of the program. This includes an overall examination of inputs and outputs:

• Demand for the program and qualifications of the applicants; • Comparisons with other global health doctoral programs; • Time to degree completion; • Peer teaching evaluations; • Formative and summative interviews with students; and, • Career choice of graduates and employment in the desired field

In addition, at the end of each quarter, students will evaluate the faculty instructor and course. The results of these evaluations will be analyzed by the Program Director, the Executive Committee, and the Curriculum Committee to assess strengths and weaknesses in the courses. Students will also have an annual evaluation with their advisors to assure that they are making satisfactory progress toward degree completion. These evaluations also will be reviewed by the Program Director and Executive Committee to determine if any interventions are needed.

Longitudinal data will be collected from alumni one-, three-, and five- year post-graduation to assess the graduates’ employment, publications, and success in acquiring grants. The Graduate Division and the Graduate Council will conduct the Academic Program Review approximately every five years according to Academic Senate regulations. This will include a self-study, external review by experts in the discipline, and a student survey.

SECTION 2. PROGRAM

2.1 Candidates’ Preparation, Admission Requirements, and Process

Minimum criteria for admission to UCSF graduate programs is determined by the Graduate Division and includes satisfactory completion of a bachelor’s degree from an accredited institution in the U.S or its international equivalent, with a GPA of 3.0. Successful candidates for admission to the GHS PhD program will also have completed a master’s degree in public health, global health, biomedical sciences, or its equivalent; or have completed a terminal professional degree, such as a DDS, MD, PharmD, MS in Nutrition, DVM, MS or DNP in Nursing. Concurrent enrollment also will be considered for students enrolled in terminal professional degree programs. Applicants will be expected to have experience working with underserved populations, prior exposure to scientific research, and have completed at least one

course each in biostatistics, epidemiology, and research methods. Applicants who do not conform to this profile may be considered on a case-by-case basis.

Admission requirements and process:

1. Completed online application and payment of the campus application fee. 2. Résumé summarizing education, professional experience, research experience, publications, honors and awards, US and international experience, volunteer work, extracurricular interests and special skills. 3. A personal statement outlining reasons for applying to the program and the area of interest (i.e. concentration), prior experience with underserved populations, and how the program will help achieve career goals. 4. Three letters of recommendation from individuals qualified to assess the applicant’s academic strengths, personal qualities, and accomplishments. 5. Original transcripts from undergraduate and graduate schools. 6. GRE scores within the last five years. 7. International applicants from non-English speaking countries must demonstrate proficiency in English by completing one year of study with a minimum GPA of 3.0 at an accredited college or university in the United States, or by obtaining specific scores on the Test Of English as a Foreign Language (TOEFL, administered by ETS), or the International English Language Testing System (IELTS, administered by the University of Cambridge, the British Council, and IELTS Australia). The minimum scores are posted at the UCSF Graduate Division website and it is incumbent upon the applicant to make sure that their scores are consistent with those required by the Graduate Division.

The admissions process will be overseen by the PhD Admissions Committee; the composition of the Admissions Committee is described in the bylaws of the PhD Graduate Group (Appendix 2).

2.2 Language Requirements

Although not an absolute requirement, proficiency in a second language will be viewed favorably. Demonstrated proficiency in a specific language will be required on a case-by-case basis in order for a student to conduct field research relevant to completion of their dissertation.

2.3 Program of Study

PhD students will be required to spend six quarters in residency and complete a total of 45 units prior to the qualifying examination and advancement to candidacy.

2.3.1 Specific Fields of Emphasis

The distinguishing feature of the graduates of this PhD program will be command of and skill in applying trandisciplinary knowledge drawing from public health, epidemiology and biostatistics, public policy, economics, development studies, clinical and basic sciences, political science, and other social sciences to address health problems of global importance.

There will be four areas of concentration in the new doctoral program that represent the strengths, research and teaching expertise, and sponsored projects within GHS, as well as the

Graduate Group and greater campus. Students will be admitted and matched to an appropriate advisor based on their area of concentration. Students will take the required courses listed in section 2.3.3 and will acquire depth and breadth in the specific concentration through participation in research rotations, electives, and independent studies with faculty.

1. Clinical concentration – non-communicable/neglected/tropical/infectious diseases and maternal/child health: a. Focus is on the major diseases that contribute to the global burden of disease and the application of research methods appropriate to interventions to decrease the global burden. 2. Policy concentration – public health policy in a globalized world: a. Focus is on independent analysis and evidence synthesis to inform discussion and decision-making on critical policy and strategic issues in global health. b. Focus is on identifying, understanding and promoting innovative models for engaging the private sector in health systems strengthening in developing countries. 3. Health systems concentration – workforce capacity and health systems strengthening: a. Focus is on identifying important models for financing and delivering health care around the world and analysis of strengths and weaknesses of various health care systems in achieving health and financial goals. b. Emphasis is on strengthening workforce capacity especially in LMIC, working with ministries of health to reduce the global burden of disease through health system strengthening employing implementation science research methods and health diplomacy strategies. 4. Social and behavioral science concentration – examples include theories related to and derived from health economics, law, medical anthropology, and medical sociology: a. Focus is on understanding health economics, legal structures, political influences and other barriers and facilitators to decreasing the global burden of disease. b. Emphasis on the social determinants of health and how social science theories such as those related to health promotion can improve health globally.

The concentrations differ from existing doctoral programs at UCSF in that the research approach and curriculum includes a synthesis of methods and courses from various fields and a transdisciplinary approach to understanding global health and its drivers. Appropriate methods for student dissertations include policy analytic techniques, implementation science, epidemiologic and biostatistical methods, and qualitative and mixed methods analysis.

As an example, the Global Health Group (GHG), previously described, is an “action tank” dedicated to identifying, elaborating, and translating innovative solutions to major global health challenges into large-scale action to advance health and save lives in low- and middle-income countries. The GHG’s team of global health experts conducts targeted research and advocacy with a focus on three areas: malaria elimination (globalhealthsciences.ucsf.edu/global-health- group/malaria-elimination-initiative); the role of the private sector (globalhealthsciences.ucsf.edu/global-health-group/private-sector-healthcare-initiative-pshi); and, translating evidence into policy (e2pi.org).

Thus, students who wish to focus on global health policy, advocacy, or financing, or those with a particular interest in malaria epidemiology, the role of the private sector, or global health governance, will affiliate with faculty in this group for research rotations and development of research proposals and dissertations. However, students in concentrations other than policy

may also choose to avail themselves of research rotations with faculty in this area. For example, a student in the health systems may also choose to work with faculty in GHG to develop expertise in the role of the private sector and how it might be mobilized to strengthen health systems. The GHS groups represent concentrations of particular interest and expertise but there is not a one-to-one correspondence between any GHS group and a concentration.

As previously described, another important group at GHS is the Prevention and Public Health Group (PPHG), which addresses both domestic health and global health through the training of local professionals, evaluation of data to inform policy, conduct of research, and building capacity. One of their areas of focus is health systems strengthening. Students who are interested in studying methods of increasing inter-professional education to strengthen health systems in low- and middle-income countries would be well matched to the PPHG.

Students with a more clinical focus will find research opportunities elsewhere at GHS. For example, a student interested in AIDS will find mentors among the faculty of the UCSF AIDS Research Institute (ARI). Similarly, a student desiring to concentrate on population control or gender-based violence in Sub-Saharan Africa could affiliate with the Bixby Center and work with Craig Cohen, Co-director of the UC-wide Center of Expertise in Women’s Health and Empowerment. That same student might also affiliate with Eric Goosby’s Center for Implementation Science to ascertain the most effective interventions for LMICs to reduce gender-based violence.

Additional examples below describe various scenarios related to the program concentrations and GHS groups and centers, as well as to applicant backgrounds and employment after completion of the PhD. As previously described, we expect that the majority of our PhD students will enter the program with some post-baccalaureate education (e.g., either master’s degrees in global or public health or as medical, dental, pharmacy or master’s level nursing students). Below, we illustrate how four students with different backgrounds might use the concentrations to focus their doctoral work and how they might prepare for subsequent careers in global health.

1. A graduate of the GHS master’s program: As mentioned, many graduates of our master’s program recognize that they would benefit from additional training; we are frequently asked when we will be admitting our first group of PhD candidates. A masters graduate might, for example, have a particular interest in community needs assessment and community engagement as they pertain to global health. Therefore, the methodological skills and research opportunities available through the social science concentration would be particularly useful. At graduation, she might take a position at a leadership level with an NGO or service organization. 2. An MPH graduate with three years of experience working as a research assistant in East Africa: Motivated by the problems he has seen, this student seeks to understand how to effect change at a regional or national level. He chooses the policy concentration and finds a mentor in the Global Health Group. After graduation, he takes a position as a project officer in a large foundation. 3. A nurse-midwife with a clinical position at a US academic health center: This student might gravitate to the Preterm Birth project, but would focus on approaches to bringing frugal interventions, such as kangaroo mother care, to scale. Having earned a PhD, she would now qualify for an academic appointment as a faculty member at her school of nursing. 4. A physician from a LMIC: This student’s clinical work has convinced him of the need for leadership in health systems strengthening in his home country. He chooses to develop

expertise in implementation science, working perhaps with the Center for Implementation Science or with the Private Sector Healthcare Initiative of the GHG. On completion of his PhD, he takes a position in his country’s Ministry of Health.

2.3.2 Unit Requirements

PhD students will be required to spend six quarters in residence. Generally, all coursework will be taken in years one and two for a minimum of 45 units prior to the written qualifying examination and advancement to candidacy. In addition, a student must register for a minimum of three quarters after advancement to candidacy.

Doctoral students will take advantage of GHS strengths in biomedical, clinical and policy research, as well as our transdisciplinary approach to training and research. Because of the diverse educational backgrounds of the applicants admitted, we expect that students in the PhD program will vary substantially in their prior preparation in epidemiology, biostatistics, mixed method analytic strategies, the social sciences, and global health coursework relevant to the study of global health and disease. Therefore, required and elective courses are available through both GHS and the wider campus offerings to prepare students for their research and future careers. It is expected that our applicants will have some knowledge of the clinical sciences that will serve as a foundation to their study and dissertation research in Global Health Sciences. The following section highlights the current understanding of transdisciplinary science and the approach we will use in integrating transdisciplinary science throughout this new doctoral program.

A definition of transdisciplinary research was offered earlier in this document. That is, “transdisciplinary research aims to integrate knowledge from various scientific and societal bodies of knowledge” (Popa F, et al., 2014) such that it will yield qualitatively different results than interdisciplinary research. Although questions related to the nature of transdisciplinary science are rife in the literature across fields as diverse as marine science (Ciannelli L, et al., 2014), ecosystems services (Costanza R, et al., 2011), and cancer research (Vogel AL, et al., 2012) transdisciplinary research is recognized as a method of addressing science and complex social problems, an approach that is especially well suited to global health research. A transdisciplinary approach uses “a shared conceptual framework and strategy to select and draw together disciplinary-specific theories, concepts, and approaches to address a particular problem.” This model is not different from the work that emanates from the population and social science disciplines, but is generally different from a basic sciences PhD. In the case of a PhD in Global Health Sciences the student may initiate a transdisciplinary approach as a means of addressing an important problem that has not previously been studied in this manner. Thus, a significant element of the intellectual work is the development of a conceptual framework and strategy that could be shared with faculty members who would agree to such an approach and support the student through exposure to theories, concepts, and methods so that the requirements of an independent and original dissertation can be met.

2.3.3 Required and Recommended Courses including Teaching Requirement

Coursework will provide the methodological expertise to design and independently conduct doctoral level dissertation research. Other coursework will survey the ongoing development of the knowledge base of the field. Electives provide the opportunity to deepen students’ knowledge in their area of concentration. It is anticipated that, while electives will be developed with a particular concentration in mind, there will be some crossover reflecting individual

students’ backgrounds, interests and goals. Electives may also be configured as independent studies or students may choose to enroll in other PhD courses on campus.

As with many doctoral programs, students’ program of study will be individualized to some extent based on their previous academic coursework. Students who have met competencies in the areas where we require coursework will be able to waive the course at the discretion of the instructor and Program Director. They will, however, be accountable for demonstrating their knowledge in the area during the qualifying examination process.

A sample program is included in section 2.11. Required courses are listed below and selected electives are listed in Appendix 1.

Required courses include:

1. Three courses in epidemiologic methods—one intermediate and two advanced level epidemiology courses; 2. Two courses in advanced level quantitative research methods—one in intermediate biostatistics and one in advanced biostatistics; 3. A minimum of one course in intermediate qualitative methods in the social sciences; 4. Two courses—Advanced Concepts in Global Health and Global Health Economics; 5. One course in communicable/infectious diseases; 6. One course in the social determinants of health; 7. One course in health systems strengthening; 8. One course in policy analysis and development; 9. Three quarters of research rotations of two units each (one rotation unit equals three rotation hours/week; two units equals 6 hours/week of research rotation or 60 hours research rotation/quarter) for a total of six units; students will be required to complete their three research rotations before they are advanced to candidacy so that they are prepared to begin writing their qualifying examinations during year two; 10. Three quarters of weekly Doctoral Seminars; and, 11. Two elective courses of which one may be an independent study with a faculty member.

Students have access to a broad array of elective courses through 1) UCSF; 2) any of the University of California campuses through the Intercampus Exchange Program; 3) the Stanford University-UCSF Exchange Program; and 4) the San Francisco Consortium of Bay Area Universities. These courses are expected to build depth in the student’s area of concentration. For example, a student in the social and behavioral sciences concentration focusing on gender based violence in low-and middle-income countries may choose GHS208 Women’s Health and Empowerment as one of two required electives. Similarly, another student in the global health policy concentration may choose elective coursework such as EPI 213 Decision and Cost- Effectiveness Analysis.

The objective of the research rotations is for the student to have the opportunity to:

1. Apply concepts taught in formal classes; 2. Learn practical aspects of conducting research, including how to work within a multidisciplinary team; 3. Acquire exposure to areas of research other than the student’s primary area; and 4. Explore and launch projects that have the potential to develop into a qualifying examination or dissertation research topic.

Research rotations are an opportunity to integrate PhD students into active research teams in GHS or other UCSF teams doing relevant research. The PhD Program Director will oversee the research rotations and training objectives. The Graduate Group Executive Committee, with input from GG members, will review annually, and revise when needed, research rotation objectives. At least one of the rotations will be guided by the student’s advisor. The Program Director will ensure that these rotations afford author-level involvement (i.e., participation in research at a level justifying future inclusion as an author on a subsequent publication) for the student. Each rotation should allow the student to create a specific product. Examples of useful research products include, but are not limited to:

1. A research questionnaire or other data collection tool; 2. An operations manual chapter; 3. Development of a human subjects protocol for approval by UCSF CHR; 4. Participation in the development and writing of a scholarly manuscript related to the research rotation; or 5. An annotated set of statistical analyses/tables/figures related to one research rotation.

Research rotations are graded on a pass/fail basis by the faculty advisor with whom the student has worked. Grades are based on the quality of the research rotation product. The following are examples of currently proposed objectives, although only some objectives will be appropriate for each research rotation:

1. Demonstrate knowledge of the proposal writing process by participating in research team meetings and planning for collaboration including conceptual discussions of research idea and framework and selection of data collection methods. 2. Exhibit knowledge of human subjects protection by writing IRB applications. 3. Make evident knowledge of research ethics through explicit discussion of ethical treatment of research subjects. 4. Validate preparation for research by: development of data collection instruments/questionnaires; obtaining informed consent on PI’s project; developing community or site relationships/entrée; and, preparing for and pilot testing various data collection methods. 5. Display knowledge of the data collection process by interviewing subjects; participating in psychosocial testing of human subjects, and collecting physiological data. 6. Demonstrate knowledge of data coding and preparation of data related to: computer data management; coding; data entry; utilizing a spreadsheet for managing data; qualitative data management; coding transcripts; and utilizing computer based programs for management of qualitative data. 7. Demonstrate knowledge of analytic strategies by: performing computerized data analysis; participating in team meetings for data analysis; and assisting with interpretation of findings. 8. Develop skills in research dissemination by: report writing; writing manuscripts; and revising manuscripts.

The two-hour weekly Doctoral Seminars (one unit of seminar credit equals two hours of classroom seminar) will begin during year one and continue during year two. The first doctoral seminar will introduce students to clinical research design including techniques for systematic review of the literature, writing measureable research questions, recruitment, sampling, validity and reliability of measurement, survey design, analytic strategies, and other topics that will conclude with the production of a ten page proposal that can be submitted for extramural

funding. Topics in the succeeding doctoral seminars will include, among others, Global Health Ethics, History of Science and History of Global Health, Responsible Conduct of Research, and issues confronted by students in global health research settings. Student preparation for qualifying examinations, development of the dissertation proposal, and writing of the dissertation will be included as well. Lastly, we will further explore the four PhD areas of concentration— clinical, policy, health systems, and social sciences—through assigned readings and presentations by experts. Faculty and students will be responsible for the presentation of Doctoral Seminar material.

During year two students will be required to submit papers related to their area of concentration. These papers will serve as the basis of their qualifying exams and dissertation proposals. In the population and social sciences it is not unusual for students to develop outlines or parts of qualifying examination papers as part of a doctoral seminar. In fact, we believe that the process of sharing their ideas with peer colleagues, as well as with the faculty member in charge, builds and extends the scientific community. The papers prepared for seminar will not be the qualifying examination papers in entirety but rather outlines, figures, annotated bibliographies, etc. that the student and the faculty member consider most likely to help move the examination process forward.

In addition to the six quarters of residency (which enforces minimum amounts of coursework), a written and oral qualifying examination and the completion of an approved dissertation are required.

Teaching Requirement: One quarter serving as a graduate student instructor is required. Teaching is available in the GHS MS program and all doctoral students are expected to work with their advisor to identify an appropriate placement. Faculty and students plan for a multi- faceted instructional experience, and concurrently examine the faculty role in university governance through readings, interviews, and observation of relevant meetings.

2.3.4 Licensure

Not applicable

2.4 Field Examinations

Not applicable

2.5 Qualifying Examinations

The purpose of the qualifying examination is to demonstrate that the student has adequate knowledge of the field and area of concentration, knows how to use academic resources, and is capable of conducting independent research for the dissertation. The following are the GHS expectations for the qualifying examination:

1. Before taking the qualifying examination, students will have completed foundational course work and completed three research rotations of at least two units each. 2. Essential qualities that should be exhibited in the focus papers are: a. Comprehensive knowledge of the literature for the area of concentration b. Critical approach to empirical evidence; and c. Integration and synthesis of ideas within each area.

Appointed in consultation with the student’s advisor and the PhD Program Director, the qualifying examination committee will be composed of at least two GHS Graduate Group members with the remainder of the faculty chosen from outside the Group. Members of the Qualifying Examination Committee from outside the GHS Graduate Group must have an appropriate level of prior experience serving on previous qualifying exam committees. Faculty members or subject matter experts from outside UCSF may be invited to serve on examination committees with the permission of the Graduate Division. In no case may the dissertation chair serve also as chair of the qualifying examination committee and in some cases it may not be in the best interests of the student for the dissertation chair to serve on the qualifying examination committee. In such cases, the PhD Program Director will identify another qualified member to serve on the qualifying exam committee.

The qualifying examination includes both the writing of the three papers, developed during the doctoral seminars and based on content from research rotations and coursework, and an oral examination based on the content of the papers. These three papers form the basis of the first three chapters of the dissertation. Typically, qualifying exams will held at the end of the second year.

At least one meeting of the entire qualifying examination committee must be held to discuss the results of the exam before a report is made to the dean of the Graduate Division. If a student fails the examination, the committee must make a recommendation for or against a second examination. If a second examination is allowed, the second qualifying examination committee must be identical in composition to the first. If the student failed in all areas, the re-examination must be on all subjects involved. A partial failure, in which the student passes some fields, but not others, also counts as a first examination. However, re-examination after partial failure may be restricted to those areas in which the original performance was unsatisfactory. A third examination is not permitted.

2.6 Dissertation

The dissertation is the final and most important step in the doctoral degree program. The dissertation will be a work of independent research that makes an original contribution to knowledge in global health, and will be of sufficient depth and quality to be submitted for publication. Each doctoral student will conduct research under the supervision of a dissertation advisor/research mentor and dissertation committee. The dissertation will follow the Graduate Division’s “Guidelines for Completion of the PhD Dissertation.”

Once a student successfully passes the qualifying examination, the student’s Dissertation Committee will be formed. The committee will consist of a minimum of three Academic Senate members who have sufficient experience to serve on dissertation committees. In some circumstances, the PhD Program Director may appoint a faculty member from outside the PhD Graduate Group to serve on the dissertation committee. Such a member would provide the necessary balance and independence needed to ensure that the student’s mastery of the subject matter is broad and comprehensive. If one or more proposed committee members are not members of the UCSF Academic Senate, the student may petition the Graduate Division to accept a non-senate member to serve on their committee. The non-senate member may not be the chair of the committee, but may serve on the committee as a regular member or co-chair with an approved Academic Senate member. The dissertation chair may not be the same person as the individual who chaired the qualifying examination committee.

Following approval of the dissertation draft by committee members the doctoral candidate will present their dissertation to the public (primarily faculty and students) and the dissertation committee will provide feedback to the doctoral candidate. Both major and/or minor changes may be required before the dissertation is filed.

2.7 Final Examination

Not applicable

2.8 Explanation of Special Requirements (if applicable)

Not applicable

2.9 Relationship of masters and doctoral programs

The GHS MS degree is a one-year, four-quarter, full-time program that requires a minimum of 36 units and a capstone project. This is a self-supporting program that enrolled 45 students from a wide diversity of backgrounds and disciplines in fall 2014.

It is expected that the proposed PhD and MS programs will be closely linked in terms of teaching, coursework, fieldwork sites, and research projects. The five GHS masters courses in which doctoral students will be enrolled are of sufficiently high quality that, through supplementation of the courses with additional readings and written requirements, the coursework will be suitably academically rigorous for doctoral students. Doctoral students will fulfill their teaching requirement by serving as teaching assistants in the MS program, and there will be the opportunity for collaboration between MS capstone projects and dissertation research topics.

There exists a current campus model, whereby doctoral students take courses in a self- supporting masters/certificate programs. In the Department of Epidemiology and Biostatistics, the Training in Clinical Research Certificate (TICR) is self-supporting, as is the masters in Clinical Research. Doctoral students in Epidemiology and Translational Science are enrolled in the TICR/masters courses for some of their coursework and serve as teaching assistants in those programs.

Because the enrollment of the GHS PhD program is relatively small (four new students admitted every other year until the program can support a new cohort each year), there will not be a significant effect on the total enrollment in the masters courses. Also, both programs will be located in Mission Hall, a new building at the UCSF Mission Bay campus that has more than adequate space to accommodate the new program.

Since numerous requests are received from the MS graduates each year for the opportunity to pursue doctoral study, it is anticipated that the program will serve as a significant pipeline for recruitment to the PhD. For example, data collected from GHS MS graduates from 2009-2012, indicates that of the 72 graduates who entered the program without a terminal degree, a total of 64 (89%) have enrolled in or plan to enroll in further graduate or professional education.

In summary, current faculty who teach and mentor students in the MS program are highly enthusiastic in their support of the PhD program. As noted in the support letter from the GHS MS Program Directors, the PhD will have a positive impact on the MS degree by: 25

• Creating the opportunity for MS and PhD students to work together on research projects; • Providing the opportunity for shared coursework across programs; • Providing opportunities for MS students to take new elective courses within the PhD program; • Serving as a pipeline for MS students who are interested in doctoral level training in global health; and, • Providing graduate student instructors for master’s courses, and conversely, providing valuable teaching experience for the PhD students.

For the reasons mentioned, we believe that it is advisable to closely link the PhD and the MS. However, we fully understand the need to ensure the academic and financial integrity of both programs. Consequently, we have worked closely with the MS Program Director, the GHS leadership, and the UCSF Budget office to ensure appropriate management of both programs in compliance with UC academic polices and those required of self-supporting programs. For example:

• The MS Program Director will be a member of the PhD Graduate Group and serve as an ex-officio member of the Executive Committee. Likewise, the MS Graduate Group bylaws will be amended to include the PhD Program Director as an ex-officio member of the MS Graduate Group and Executive Committee. • The PhD Program will be housed in the Education Unit of GHS, just as the MS degree program, both with administrative oversight by the GHS Education Director. Staff for both the MS and PhD degree will be housed in the same location offering easy access for planning and program coordination. • Fundraising activities for scholarships will be synergistic and under the auspices of the GHS Development Officer. • The UCSF Budget Office provides annual reviews of the MS self-supporting program budget and the GHS Education Officer will be responsible for the management of budgets and operations for both degree programs.

2.10 Special Preparation for Careers in Teaching

Each doctoral student will be required to serve as a teaching assistant for one quarter, but there will be no special preparation to prepare students for a career in teaching.

2.11 Sample Program

Below is a sample program for the PhD program. Students who have previously completed the coursework or demonstrate competencies in the subject area may be approved for a waiver of the required coursework by the faculty instructor and Program Director.

Year Quarter Course Units 2015 Fall EPI 203 – Epidemiologic Methods 4 GHS 201C - Social and Behavioral Science Approaches in Global Health 2 GHS XXX – Advanced Concepts in Global Health 2 GHS XXX – Proposal Writing & Doctoral Seminar 1 (2 hours/week) 2016 Winter EPI 207- Epidemiologic Methods II 3 GHS 202A - Communicable Diseases of Global Importance 3 BIOSTAT 208- Biostatistical Methods for Clinical Research II 3 GHS XXX Research Rotation #1 1

Year Quarter Course Units 2016 Spring BIOSTAT 209 - Biostatistical Methods for Clinical Research III 3 GHS XXX Health Systems Strengthening 2 GHS XXX Research Rotation #2 2 (6 hours/week) GHS 205 - Global Health Policy—Transforming Evidence Into Action 2 2016 Fall GHS 201B - Global Health Economics 2 GHS XXX Research Rotation #3 2 (6 hours/week) Doctoral Seminar #2 1 (2 hours/week) Elective #1 3 2017 Winter GHS 202B – Sociocultural and Behavioral Determinants of Health 3 Doctoral Seminar #3 1 Elective #2 2 2017 Spring EPI 265 - Research Methods in Chronic Disease Epidemiology 3 Qualifying Examinations Preparation & Oral Exam Individually determined 2017 Summer Dissertation Proposal Approval Individually determined 2017 Fall Data Collection and Writing Individually determined 2018 Winter Data Collection and Writing Individually determined 2018 Spring Data Collection and Writing Individually determined 2018 Fall Data Collection and Writing Individually determined 2019 Winter Data Collection and Writing Individually determined 2019 Spring Data Collection and Writing Individually determined Total number of units 45 units

2.12 Normative Time for Matriculation to Degree

Normative time to degree for GHS PhD students is expected to be four years, but will ultimately depend on the background, preparation, and proposed research topic of the individual student. The pre-candidacy period will include two years of coursework; students are expected to advance to candidacy in spring quarter of the second year; dissertation research and writing will occur in years three and four.

SECTION 3. PROJECTED NEED

3.1 Student Demand for the Program

According to an unpublished web-based survey conducted by the UC Global Health Institute (UCGHI), there has been exponential growth in the number of global health academic programs nationally between 2001 and 2011.

Additionally, a May 2014 report in the New England Journal of Medicine by Michael Merson indicates that approximately 250 North American universities have global health education offerings at the undergraduate and graduate levels. The Association of Schools and Programs of Public Health has developed a global health competency model and 20% of US medical specialty residency programs have global health activities. This immense growth in global health offerings at all levels of academic and professional education suggests the need for more research trained faculty and thus a unique role for UCSF’s proposed program.

Another UCGHI sponsored report, The Importance of the Global Health Sector in California: An Evaluation of the Economic Impact, published in 2009, suggests that the time is right for a PhD program in global health at UCSF. Interest in global health is intensifying among university leaders, faculty members, and students at the same time that “borderless” health issues and rapidly globalizing societies are crying out for greater academic global health involvement. Important reasons for including global health programs in academic environments include: 1) student interest - about 75% of students state that they are interested in acquiring knowledge germane to global health; 2) societal responsibility of universities to improve the human condition which in turn offers scientific opportunities for US investigators to extend their training and research across different disciplines; 3) programs in global health position universities to contribute and compete in our globalized world; 4) investments in global health research may benefit the US as well as lower and middle income countries by influencing the quality and costs of health care.

We propose an enrollment of four new students every other year until demand and funding allow us to increase enrollment. We expect no difficulty in finding high quality applicants to fill a class of this size, as most top-rated programs in global health turn away strong applicants. The following are tables of peer institutions, noting the number of applications received each year and the number of students admitted. It is clear from this information that there are many more students interested in PhD programs in Global Health or in PhDs in Public Health with a global health focus than there are available openings. Additionally, we present profiles of universities offering global health tracks; characteristics of the top five universities with PhD programs in public health; and, the characteristics of the California public and private universities offering public health programs. Since there are only three programs in the US offering PhDs in global health, all with foci very different from our proposed areas of concentration, we believe this is the time for UCSF to offer such a program.

Profile at Peer Institutions Offering the PhD in Global Health Institution and Applications Students Desired Areas of Training Funding Sources Year Initiated Admitted Employment Areas Arizona State 12-14 5-6 50% academia; Complex adaptive Faculty grants University - 50% NGOs systems science; 2005 Health & culture; Urbanism University of 70-100 7 No graduates yet; Global health metrics; Research and Washington- preparation is for Implementation teaching 2012 academia Science assistantships for both domestic and international students University of 18-20 5-7 Academia incl. Global Health and the Research and Florida- research & labs; Environment; One teaching Gainesville - federal agencies Health (med, vet, & assistantships 2010 environment)

Profile of Universities offering Global or International Health Tracks Institution and Applications Students Desired Areas of Training Funding Year Initiated Admitted Employment Sources Areas Duke University Scholars 6-8 Scholars-2 Environmental; Doctoral Scholars Duke GH Certificate- Certificate-8 public policy; Doctoral Certificate Institute provides No doctoral level NA clinical psychology; in various areas of 50% of tuition & PhD program; MS civil engineering faculty research stipend to only. A doctoral Doctoral scholars program Scholars. and certificate Doctoral program. Certificate program funded Doctoral by competitive scholars-2010; grants Certificate-2013 UCSD/SDSU 40 Accept 4-7; Bilateral federal Epidemiology, Mentors provide Joint PhD enroll 1-2 organizations Health Behavior, 2 years of program in (CDC); academia; Global Health funding to all Epidemiology, NGOs; US students; Health Behavior, community health teaching Global Health- work assistantships 2008 available

Tulane University 300-400 Accept 80; CDC; NGOs; NIH; Biostat and Limited number PhD in Public enroll 25 academic Bioinformatics; Epi; of partial and full Health with postdoctoral Global Community fellowships Global Health fellowships Health and tracks Behavioral Sciences; Global 2011- global Environmental health track; Health Sciences; School of Public Global Health Health & Tropical Medicine Brandeis Unclear Unavailable Prepare health and GH and Info unavailable University development Development Policy PhD awarded by economists and concentration; the Heller School social policy purpose is to for Social Policy analysts address problems of and Management poverty and ill health in low-income countries Columbia Unclear Unclear as to Since this is a DrPH in Leadership Limited financial University number of leadership in Global Health and aid. applicants program most of Humanitarian Intended for and number the applicants hold Systems launched in leaders in public admitted positions that are Fall 2012. health public health oriented.

Characteristics of Top 5 US Schools of Public Health*

Institution Areas of Training Student Body & Admission Other Financial Aid Requirements Columbia • Biostatistics Doctoral students Most applicants have Population and • Environmental Health comprise 14% of a 3.3 or >GPA; GREs Family Health Sciences their 1,293 student are required. • Epidemiology body. Scholarships, • Health Policy and fellowships, and Management grants are available. • Socio-medical Sciences Harvard Division of Biological Sciences Students in PhD Bachelor’s degree as Offers a Doctor of • Biostatistics program have 5 well as competence Science and a • Health Policy years of tuition & in coursework DrPH as well as the stipend support matching area of PhD, under the training. aegis of the GREs required. Harvard Graduate School of Arts and Sciences. New DrPH in Global Health initiated in July 2014 Johns Departments of: Limited number of GRE required; some -- Hopkins • Biochemistry and full tuition fields require BS or Molecular Biology scholarships; MS in biostats, stats • Biostatistics however, after 6 full or closely related field • Environmental Health terms all students Sciences receive 75% tuition • Epidemiology scholarships • Health Policy and Management • Mental Health

• Molecular Microbiology and Immunology • Population, Family and Reproductive Health • Graduate Training Programs in Clinical Investigation UNC- • Biostatistics Limited number of Bachelor’s degree in Graduate Chapel Hill • Environmental Science and full-tuition a related field and Certificate in Global Engineering scholarships acceptable GREs. Health prepares • Epidemiology residential graduate • Health Behavior students to work in • Maternal and Child Health changing • Nutrition environments and • Health policy and with diverse management populations • Public health Leadership U of • Biostatistics Limited funding for No required courses Michigan • Epidemiology tuition and stipends. or prerequisites for • Environmental Health most programs with Sciences/ Toxicology exceptions for • Health Behavior and Environmental Health Health Education Sciences and • Health Services Biostatistics. Organization and Policy Require GREs and GPA>3.0 *US News and World Report ranking of top 5 public health PhD programs

Profile of California Public and Private Universities with Public Health/Global Health Offerings

Institution Public/Global Health Offerings Other

University of PhD tracks: The Global Health California, Berkeley • Biostatistics Specialty Area has been School of Public • Environmental Health Sciences suspended until further Health • Epidemiology notice. • Health Services & Policy Analysis • Infectious Diseases & Immunology University of PhD tracks: California, Los • Biostatistics Angeles • Community Health Sciences Fielding School of • Environmental Health Sciences Public Health • Epidemiology • Health Policy and Management. University of PhD tracks: California, Davis • Epidemiology School of Public • Biostatistics Health • Pharmacology & Toxicology Stanford University The Center for Innovation in Global Health (CIGH) aims to No PhD programs in Center for Innovation provide undergraduate students with opportunities to achieve Public or Global Health in Global Health a well-rounded experience that incorporates an understanding of the global environment University of Southern • BS in Global Health (undergraduate) No PhD programs in California • MS in Global Medicine: Public or Global Health • MPH in Global Health Leadership

3.2 Opportunities for Placements of Graduates

As already outlined in this document, there are only three universities in the US offering a PhD in global health and five universities with global health areas of specialization at the PhD level. Additionally, there are numerous masters and DrPH programs in global health in the US that are either currently operational or being planned and thus will need doctorally prepared faculty in leadership and academic roles. Many global health education and training programs also have partnerships with LMICs and are involved in capacity building and health systems strengthening abroad. Therefore, Global Health is a growing area of academic employment in US universities and is an opportunity for the UCSF GHS graduates’ placements.

In addition to academic career paths with universities, our PhD graduates will be uniquely prepared to offer leadership and research expertise within governmental, non-governmental and bilateral/multilateral organizations focusing on global health. It is expected that our graduates would be competitive for positions within the National Institutes of Health, USAID, the Fogarty International Center of the NIH, the US Department of Defense, WHO, the Global Fund to Fight AIDS, TB, and Malaria, GAVI (Global Alliance for Vaccines and Immunization), and the Bill & Melinda Gates Foundation. In addition, our international graduates will contribute leadership capacity to their ministries of health and education, as well as international NGOs.

Lastly, the private sector offers opportunities for research. These include pharmaceutical companies; see, among others, Burroughs-Wellcome (www.bwfund.org/grant- programs/biomedical-sciences/career-awards-medical-scientists), Gilead (www.gilead.com/research/investigator-sponsored), and Pfizer (www.pfizer.com/research). These private sector multinationals have offices worldwide with many career options, including those that would use the skills of our PhD graduates. Global Health Sciences has a Private Healthcare Sector Initiative (PHSi) that works to advance the understanding of private sector healthcare provision in developing countries. Given the primacy of private healthcare services in developing countries, especially for the poorest populations, the private sector is a crucial focus area for overall health systems strengthening. Our students will have ample opportunity to study with mentors whose research involves the private healthcare sector from a global health perspective.

3.3 Importance to the Discipline

Global health is a developing field with its own developing body of disciplinary knowledge. This knowledge is transdisciplinary in scope, drawing from public health, epidemiology and biostatistics, public policy, development studies, clinical and basic sciences, economics, political science, and other social sciences. UCSF Global Health Sciences, as a leader nationally and internationally in global health, is in a unique position to build the substantive body of theoretical and research knowledge that is key to the foundation of a new discipline. The aim of this program, to prepare doctoral level graduates competent to apply research methods to explore and solve global health problems within academia, bilateral, multilateral and non-governmental organizations, will accelerate the growth of the discipline. For example, we expect our graduates to be in the vanguard of global health research and to aid in further establishing the theoretical, methodological, and substantive body of knowledge that are related to this new academic discipline.

The PhD Program in Global Health Sciences will be housed within UCSF, which will allow it to become a premier intellectual and geographical setting for researchers interested in the field.

UCSF is ranked first among public institutions and first among all institutions nationwide in research support from the National Institutes of Health (NIH) for fiscal year 2013. Acclaimed faculty within GHS are conducting investigations involving malaria, HIV/AIDS, workforce issues, women’s reproductive health, child health, environmental influences on human health, and many other areas of unique global health research.

3.4 Ways the Program Will Meet the Needs of Society

Global health activities play a vital role in the economy of California, as described in The University of California Global Health Institute (UCGHI) report titled The Importance of the Global Health Sector in California: An Evaluation of the Economic Impact. California has the largest economy of any US state and one of the ten largest in the world. It is known worldwide as a trendsetter and innovator, as the birthplace of biotechnology and the place where information technology was conceived and initially developed. California’s economic position in the world, the depth of its intellectual and creative resources and its geographic position on the Pacific Rim and proximity to Latin America make it a magnet for international activity, including that related to global health.

The report noted that California’s academic community is an important actor in global health in California with a total business activity of almost $4 billion in 2007. This is almost certainly an underestimation of impact since the study was restricted to research activity only and, in addition, only research supported by local, state or federal grants. The report demonstrates the economic advantages of global health endeavors to the state of California. Additionally, there are advantages that accrue to other states, universities, and bilateral-multilateral organizations as well as non-governmental organizations.

We will prepare graduates who can provide leadership to bilateral, multilateral and non- governmental organizations. Currently, many developed countries are making massive government investments in global health, but leadership in organizations at the forefront of these investments is generally limited. Our graduates will be able to provide this leadership armed with sound research methodology, strong clinical backgrounds, and theoretical understanding pertinent to work at the international, regional and national levels.

3.5 Relationship of the Program to Research and/or Professional Interests of the Faculty

As an internationally renowned health science campus, UCSF has extensive global health research projects throughout the world. The Global Research Projects database (globalprojects.ucsf.edu) highlights the work of more than 600 UCSF investigators conducting projects in more than 190 countries. These diverse research and training projects encompass the fields of policy, epidemiology, behavioral science, diagnostics and drug development, clinical trials, bench science and implementation. Key UCSF areas of focus include HIV, malaria, tuberculosis, maternal/child health, in addition to cross-cutting themes such as implementation science and economics. As a leading educational institution, UCSF is also active in training and capacity building activities world-wide.

In addition to the extensive research projects within Global Health Sciences described in section 1.2.1 above, other closely aligned programs include the following:

• The mission of the Bixby Center for Reproductive Health is to advance women's health worldwide through research, training, policy analysis and services. The Bixby Center is

the parent organization for the Family AIDS Care and Education Services (FACES) program and the Safe Motherhood Initiative. • The Center for Tobacco Control Research and Education serves as a focal point for a broad range of research, education, and public service activities for 46 faculty members in 11 departments and all four schools at UCSF, as well as colleagues at UC Berkeley and UC Merced. It is part of the UCSF Cardiovascular Research Institute and its membership is congruent with the UCSF Helen Diller Family Comprehensive Cancer Center’s Tobacco Control Program. The Center is also a WHO Collaborating Centre on Tobacco Control. • The Proctor Foundation was founded in 1947 with the specific aim of eradicating trachoma worldwide. Since that time, it has evolved into a major research and teaching unit at UCSF, and its goal has broadened to the prevention and treatment of blindness worldwide. The International Programs division at Proctor has taken over the original goal of the foundation and has focused on the prevention of blindness programs in Asia and Africa. • The San Francisco General HIV/AIDS Division is engaged in research and education around the world. Their partnerships address the most pressing issues of the HIV epidemic in resource limited settings. Projects span disease pathogenesis to epidemiology to treatment to models of care delivery. The HIV/AIDS Division co-directs the Makerere University–UCSF research collaboration which has enrolled over 20,000 patients on clinical studies evaluating HIV, TB, malaria, and nutrition in Uganda. • UCSF Gladstone Institute of Virology and Immunology research at Gladstone is focused primarily on three primary and urgent challenges in HIV/AIDS. Development of a vaccine for those at risk of coming in contact with the virus, as well as a cure for the millions of people who are already infected are two; the third is to discover new approaches for restoring a normal lifespan to those who are HIV-positive—but dying much too early from diseases of aging. • UCSF Institute of Health and Aging was the University of California's first campus-wide organized research unit (ORU) devoted to the study of health and aging issues. The original mission of the Institute was to “foster multidisciplinary, collaborative research, education, and public service in the field of health and aging.” Over the years, the mission of the Institute has continued to stress multidisciplinary, collaborative research, education, and public service. Within these three realms, the Institute has expanded its research interests to encompass more broadly issues of health, illness, and social and economic policy research that impact the aging process and the elderly population. • The mission of the Philip R. Lee Institute for Health Policy Studies is to contribute to the solution of complex and challenging problems through leadership in health policy and health services research, education and training, technical assistance, and public service. The Institute conducts, synthesizes, and translates research among multiple academic disciplines and fields to provide a base of evidence to share with people who make decisions about health and health care. They focus on providing information about policy decisions that will affect people’s health and lives, from helping to improve clinical decision-making at a patient’s bedside to assessing the potential impact of state and national health legislation. • The Center for Health and Community at UCSF was established to assess the challenges of the changing health care delivery environment and identify policies and interventions that will maximize the beneficial impact of the changing health care delivery system. The Center is comprised of programs and individual faculty from all UCSF Schools who have been at the cutting edge of health services and policy-related research. The Center also plays a leading role in developing innovative curricula for both

pre-clinical and clinical years that will promote an understanding of the contributions of non-biological factors to health, disease, and recovery.

3.6 Program Differentiation

As indicated previously, there is currently no PhD program in Global Health Sciences in the UC system and only very few nationally. This program will differ from existing programs that primarily fall within Public Health doctoral degrees with a global health emphasis by focusing in four specific areas:

1. Clinical concentration – non-communicable/neglected/tropical/infectious diseases and maternal/child health. 2. Policy concentration – public health policy in a globalized world. 3. Health systems concentration – workforce capacity and health systems strengthening. 4. Social and behavioral science concentration – examples include theories related to and derived from health economics, law, medical anthropology, and medical sociology.

These are areas of demonstrated strength at UCSF and reflect the active research programs of GHS faculty. Although there are other complementary programs at UCSF, such as the newly approved MS program in Health Policy and Law, offered jointly by the Institute for Health Policy (SOM) and Hastings Law School, this innovative, self-supporting program is primarily directed at health policy and law in the US rather than globally. Other health policy programs include the Health Policy masters and PhD tracks in the Department of Social and Behavioral Sciences (SON) that is also focused primarily on the US. As described, the PhD in Epidemiology and Translational Science is related to the proposed PhD and GHS doctoral students and Epi doctoral students are expected to share coursework. The PhD in Global Health Sciences, however, can be differentiated from these and other programs by its primary focus on global health and its emphasis on transdisciplinary science.

SECTION 4. FACULTY

4.1 List of Faculty Members, Ranks, and Highest Degrees

Faculty for the doctoral program will be drawn from the existing MS Graduate Group in Global Health Sciences, instructors in the MS program, GHS faculty program directors, and other UCSF faculty from the four schools who have expertise in doctoral level training and relevant research expertise. Over 50% of the inaugural GHS PhD Graduate Group has had experience serving on five or more PhD qualifying exam and/or dissertation committees; biosketches are located in Appendix 5, which includes their area of expertise. Below is a list of the Graduate Group members and the PhD areas of concentration for which they will provide advising and mentoring.

Graduate Group Area of Concentration for Member Degree Rank Advising/Mentoring Adams, Vincanne PhD Professor Social & Behav. Science Adler, Nancy PhD Professor Policy Baltzell, Kimberly PhD, MS Assistant Professor Clinical Brindis, Claire MPH, DrPH Professor Policy Professor, Associate Brock, Tina MS, EdD Dean Clinical Burke, Nancy MA, PhD Associate Professor Social & Behav. Science Coates, Thomas MA, PhD Professor Policy, Health Systems Cohen, Craig MD, MPH Professor Clinical, Health Systems Cooke, Molly MD Professor Clinical, Health Systems Craik, Charles MA, PhD Professor Clinical Dandu, Madhavi MD, MPH Associate Professor Clinical, Health Systems Dawson-Rose, Policy, Social & Behav. Carol PhD, RN Associate Professor Science Professor, Dean Emeritus, Former Clinical, Policy, Health Debas, Haile MD Chancellor Systems Policy, Social & Behav. Dohan, Daniel PhD Professor Science Dow, William PhD Professor Policy Professor, Associate Dworkin, Shari PhD, MS Dean Social & Behav. Science Enanoria, Wayne MPH, PhD Assistant Professor Clinical Feachem, Sir Clinical, Policy, Health Richard FREng, DSc(Med), PhD Professor Systems Gershon, Robyn MHS, DrPH Professor Policy Policy, Social & Behav. Glantz, Stanton PhD Professor Science Glymour, Maria MS, ScD Associate Professor Social & Behav. Science Clinical, Policy, Health Goosby, Eric MD HS Clinical Instructor Systems Gosling, Roland (Roly) MD, PhD Associate Professor Clinical, Policy PhD, MRCPath, Professor, Associate Greenspan, John FRCPath Dean Clinical, Health Systems

Havlir, Diane MD Professor Clinical Project Director/ Clinical, Social & Behav. Hemmerling, Anke MD, PhD, MPH Academic Coordinator II Science Hiatt, Robert MD, MPH, PhD Professor, Chair Clinical, Health Systems Hills, Nancy PhD Associate Professor Health Systems Justice, Judith PhD, MPH Associate Professor Social & Behav. Science Kahn, Jim G. MD, MPH Professor Policy, Health Systems Lindan, Krysia MD, MS Associate Professor Policy, Health Systems Macfarlane, Sarah MSc Econ, PhD Professor Health Systems Martin, Jeffrey MD, MPH Professor Clinical, Health Systems Martin-Holland, Judy RN, PhD Associate Dean Policy, Health Systems Max, Wendy MA, PhD Professor Policy, Health Systems Miller, Suellen PhD, RN CNM, MHA Professor Clinical, Health Systems Montagu, Dominic MBA, MPH, DrPH Associate Professor Policy, Health Systems Partridge, Colin MD, MPH Professor Clinical Health Systems, Social & Portillo, Carmen RN, PhD Professor Behav. Health Systems, Social & Rankin, Sally RN, PhD Professor Behav. Professor, Associate Reingold, Art MD Dean Clinical, Health Systems Reynolds, Teri Ann PhD, MD, MS Assistant Professor Clinical, Health Systems Rosenthal, Philip MD Professor Clinical Clinical, Policy, Health Rutherford, George MD, MA Professor, Vice Chair Systems Schillinger, Dean MD Professor Clinical, Health Systems Schwarcz, Sandy MD, MPH Assistant Professor Clinical, Health Systems Clinical, Policy, Health Sepulveda, Jaime MD, MPH, MSc, DrSc Professor Systems Seward, James MD, MPP Professor Clinical Shiboski, Caroline DDS, MPH, PhD Professor Clinical, Health Systems Health Systems, Social & Steward, Wayne PhD, MS Associate Professor Behav. Stewart, Chris MA, MD Professor Clinical, Health Systems Clinical, Social & Behav. Thompson, Lisa RN, PhD Associate Professor Science Health Systems, Social & Vlahov, David RN, PhD Dean, Professor Behav. Volberding, Paul MD Professor Clinical, Health Systems Whitmarsh, Ian PhD Associate Professor Social & Behav. Science Yamey, Gavin MB BS, MRCP, MSc Associate Professor Policy, Health Systems Zablotska, Lydia MD, MPA, PhD Associate Professor Clinical, Health Systems Ziegler, John MD, MSc Professor Emeritus Clinical, Health Systems Zimmer, Zachary PhD Professor Social & Behav. Science

4.2 Commitment Letters from Faculty

Commitment letters from the faculty are included in Appendix 3.

4.3 Letters of Departmental, School, and Program Support

Letters of support are included in Appendix 4.

SECTION 5. COURSES

5.1 Description of Present and Proposed New Courses

The following are present and proposed courses for the PhD in Global Health Sciences (proposed courses are indicated with an asterisk), which include currently offered GHS MS courses, new courses to be developed, and existing campus courses. Given the relatively small class size of the PhD program (four students every other year until there is sufficient funding to admit a cohort on a yearly basis) there will be minimal to no impact on existing course loads. Since the MS program is a self-supporting program, however, funding will be provided to cover the costs of the additional students in each course (estimates are included in the budget below– Section 7). The GHS PhD program will reimburse the Training in Clinical Research (TICR) program for the four courses that comprise part of the core curriculum in global health. It is expected that newly developed PhD courses and future MS electives will be open to other UCSF learners.

The transdisciplinary nature of global health requires coursework in a number of different fields and from faculty in other departments and schools. The courses described below are required for all students. For those students who have completed previous coursework in Public or Global health, waivers and substitutions may be approved in consultation with instructors and the Program Director.

EPI 203 Intermediate Epidemiology (4 units)

All clinical research regardless if classified as patient-oriented, translational, epidemiologic, comparative effectiveness, behavioral, outcomes, or health services research has individual human beings or groups of human beings as its unit of observation. As such, principles of epidemiology serve as the basic scientific methodology of all clinical research. The objectives of this course are to provide a detailed understanding of the basic principles of epidemiology including:

• diverse array of study designs, and their theoretical interrelatedness, available in clinical and epidemiologic research; • importance of measurement; • different types of measures of disease occurrence; • methods to measure risk factor ("exposure") - disease ("outcome") association; • measures of attributable risk; • interaction; • approaches to identify and minimize selection, measurement and confounding bias; and

• conceptual motivation for more sophisticated methods (e.g., regression or marginal structural approaches) to manage confounding, which are increasingly common tools in epidemiologic analyses. (Faculty: Department of Epidemiology and Translational Science)

GHS 201C – Social and Behavioral Science Approaches in Global Health (2 units)

This course covers research methods appropriate for addressing social and behavioral science research questions in global health. It addresses the following areas: methods health professionals use to attain competence in the socio-political-cultural environments where they work; ethnographic methods, surveys, and key informant interviews to gather relevant health data; social and behavioral science researchers’ preparation for global health field research, including moving from data to problem; and, best methods for qualitative data coding and analysis. (Faculty: Global Health Sciences)

GHS XXX – Advanced Concepts in Global Health (2 units)

This course will investigate the advanced concepts involved in global health that are related to the global health competencies in education as articulated by various groups involved in global health education.4,5 These include the global burden of disease; the social/cultural/environmental determinants of health; the divergence in health systems funding, governance, and leadership internationally and at the local and national US levels; the need for health systems management and leadership in the health workforce crisis; and health as a right and development resource. A recurring theme will emphasize the evolving structural landscape of multi-sectoral global health institutions ranging from governments, bilateral and multilateral organizations, NGOs, civil society, and the private sector. (Faculty: Global Health Sciences)

GHS XXX – Doctoral Seminar - Designing a Global Health Research Proposal (1 unit)

This course is an introduction to the process of proposal writing with particular emphasis related to problems in global health. The focus is on clinical research, defined broadly as patient- oriented, translational, epidemiologic, comparative effectiveness, behavioral, outcomes, or health services research. Students will learn the skills required to effectively critique the existing research in their area of study; how to design a study from the writing of research aims and hypotheses to the choice of appropriate research methods and the correct analytic techniques for data analysis. The product of the course is a research proposal suitable for submission to an extramural funder. (Faculty: Global Health Sciences)

EPI 207 – Epidemiologic Methods II (3 units)

Epidemiologic Methods II extends upon the topics taught in Epidemiologic Methods (EPI 203) and includes more advanced instruction in the methodologies central to epidemiologic research. Topics will include: the interrelationships between various measures of disease occurrence and association; concepts of attributable risk; interactions; practical and theoretical considerations of the most common study designs in observational research; methods of reducing confounding

4 Pfeiffer J, Beschta J, Hohl S et al. (2013). Competency-based curricula to transform global health: Redesign with the end in mind. Academic Medicine, 88 (1), pp. 131-136. 5 Global Health Education Consortium and Association of Faculties of Medicine of Canada (AFMC) on globalhealthcompetencies.wikispaces.com/;accessed 9-2-14. 39 including matching, instrumental variables and propensity scores. More advanced analytic techniques specific to epidemiologic research are covered, including regression model building and diagnostics and hierarchical modeling. There is also in depth instruction in quantitative bias analysis for misclassification, selection bias, and unmeasured confounding. The main objective of the course is to enhance a student’s ability to design and conduct unbiased and efficient research. (Faculty: Epidemiology and Biostatistics).

GHS 202A – Communicable Diseases of Global Importance (3 units)

This course approaches the global burden of communicable disease from the perspectives of biology, history, epidemiology, economics, prevention and control. The course broadly covers the basic principles of infection, inflammation, and immunity, the pathogenesis and major types of communicable infections, with a focus on HIV, malaria and tuberculosis, and the environmental and public health control measures for major communicable diseases. Through a combination of lectures, seminars and independent study, students will learn about communicable diseases of global importance, concepts of surveillance and outbreak investigations, vaccine programs, emerging infections, low-technology solutions to disease control in the developing world, and the global/economic politics of infectious diseases. (Faculty: Global Health Sciences)

BIOSTAT 208 – Biostatistical Methods for Clinical Research II (3 units)

This is an intermediate level course in statistics, covering multi-predictor methods, including exploratory data analysis and multiple regression (linear and logistic). Emphasis is on the practical and proper use of statistical methodology and its interpretation. The statistics package STATA will be used throughout the course. At the end of the course, students will be able to:

• Describe the roles of descriptive versus inferential statistics. • Identify characteristics of the problem to help choose the appropriate analytic technique. • Describe techniques appropriate for handling a single outcome variable and multiple predictors. (Faculty: Epidemiology and Biostatistics)

BIOSTAT 209 – Biostatistical Methods for Clinical Research III (3 units)

This is the third course in the TICR/Epi Program biostatistics sequence, covering multi-predictor variable methods in the context of survival analysis and repeated measures analysis. Emphasis is on the practical and proper use of statistical methodology and its interpretation. The statistics package STATA will be used throughout the course. At the end of the course, students will be able to:

• Understand the basics of survival analysis • Apply Cox regression in multiple predictor variable settings • Understand the basic concepts of repeated measures data • Apply multiple predictor regression in the repeated measures setting • Perform and summarize the results of a data analysis. (Faculty: Epidemiology and Biostatistics)

GHS XXX – Health Systems Strengthening (2 units)

According to the WHO, health systems strengthening can be defined as: 1) the process of identifying and implementing the changes in policy and practice in a country’s health system such that the country can respond better to its health and health system challenges and 2) any array of initiatives and strategies that improves one or more of the functions of the health system and that leads to better health through improvements in access, coverage, quality, or efficiency. Health systems strengthening involves a systematic, evidence-based approach designed to bring about significant improvement in patient and population health outcomes, efficiency and effectiveness of systems and processes of care, and social responsiveness and accountability. Building and strengthening workforce capacity, strengthening the medical supply chain, understanding systems logistics, and devising logic models to measure health systems change are included. (Faculty: Global Health Sciences)

GHS 205 – Global Health Policy—Transforming Evidence into Action (2 units)

Students will examine different policy environments using selected case studies. Using Walt and Gilson’s “policy triangle” as an organizing framework (Walt & Gilson, 1994), students will examine global health interventions ranging from disease control to eradication that represent both policy successes and failures. The role of agenda setting, stakeholders, power, advocacy, and the political process in policy development will be examined. In conjunction with the University of Sheffield UK and the Karolinska Institute, UCSF has produced the first ever comprehensive textbook on global health policy, called The Handbook of Global Health Policy, which will be published in the US in June 2014. (Faculty: Global Health Sciences)

GHS 201B – Global Health Economics (2 units)

This course explores the role of economics in global health. It reviews the history of health systems development (organization, financing) and examines health metrics and measurement of disease burden at the population level. A focus will be on the impact of social, political and economic globalization on public health and will analyze economic inequality as a determinant of social and health disparities. The course will pursue the major debates in economic development is some detail, looking at poverty reduction schemes (e.g. aid, microfinance, social entrepreneurism) and evidence-based health systems reform. (Faculty: Global Health Sciences)

GHS XXX – Doctoral Seminars 2 and 3 (1 unit each with 1 unit=2 hours of seminar/week)

Doctoral seminars are required of all students and faculty from GHS will rotate responsibility for leadership during each of the three seminars. Topics will include Global Health Ethics, History of Science and History of Global Health, Responsible Conduct of Research, student preparation for qualifying examinations, development of the dissertation proposal, writing of the dissertation, and other topics. Additionally, we will further explore the four areas identified as PhD tracks including: non-communicable/neglected/tropical/infectious diseases; global health policy; workforce and health systems strengthening; and social and behavioral sciences (health economics and behavior change). Faculty and students will take responsibility for leading the seminars. (Faculty: Global Health Sciences)

GHS 202B – Sociocultural and Behavioral Determinants of Health (3 units)

This course will examine social, cultural and behavioral determents of health. Moving from social theories to behavior, the course will cover the effects of socio-economic inequality and other forms of health disparities on population health. The course will draw on faculty expertise and experience in a variety of global contexts, allowing students to compare and contrast the varied influences of cultures on health. The course will combine the methodological approaches of anthropologists, sociologists, and behavioral scientists to inform health promotion strategies and health-seeking behavior. Throughout the course we will emphasize the complex, transdisciplinary interactions between human society and health. The content of this course examines the confluence of social and cultural factors (including globalization, the impact of social, economic, and political systems, the local and global economy, transnational organizations, culture, race, class, gender, sexuality, and North/South inequality) that lead to disparities in health both domestically and globally. (Faculty: Global Health Sciences)

EPI 265 – Research Methods in Chronic Disease Epidemiology (3 units

The class will emphasize the determinants of disease incidence and the challenges of causal inference from observational studies. We will review alternative study designs, and equip students to propose alternative approaches to evaluating a research question. In particular, students will understand the trade-offs implicit in any particular chosen design relating to sample size and generalizability, measurement validity and precision, and internal validity. These considerations will be contextualized within extant literature on chronic disease epidemiology, focusing on particular 'hot-topic' theoretical debates, such as early life sensitive periods, the obesity epidemic, determinants of dementia, and cohort trends in chronic disease incidence and prevalence. (Faculty: Epidemiology and Biostatistics)

SECTION 6. RESOURCE REQUIREMENTS

6.1 FTE Faculty and Staff Organizational Chart

The GHS Education unit currently consists of an education director, three faculty program directors, and a PhD director. In addition, there are five staff members supporting the educational programs of GHS, with the expectation that a sixth staff coordinator will be hired to support the doctoral program. Teaching faculty will be recruited from current GHS units, the MS and PhD Graduate Groups, and other schoools and departments at UCSF. Below is an organizational chart of the GHS Education program.

GHS Education Program Organizational Chart

6.2 Library Acquisitions

There are no additional library acquisitions that will be necessary for the PhD program. The books and journals necessary for the graduate program are already available in the library or on-line. These materials are essential to the on-going research of many of UCSFs existing faculty and students.

6.3 Computing Costs

All students will be expected to have their own computers and internet access and will receive the standard computer support of all students. Students will be required to cover the costs of specific software (i.e. STATA, SPSS).

6.4 Equipment

Other than the normal equipment necessary for the administration of the program, no additional equipment costs are expected.

6.5 Space and Other Capital Facilities

The doctoral program will be housed in the new Mission Bay building completed in October 2014, Mission Hall: Global Health and Clinical Science. Global Health Sciences faculty and staff will be located on the third floor of the facility; state-of-the-art classrooms and common areas comprise the first floor. Also included will be a student lounge, study space, satellite office for student services, and a café.

6.6 Other Operating Costs

Since many students in the program will conduct international research, GHS will put additional effort into securing gift funds to help support student travel costs. Students will also work with their PIs and advisors to obtain funding, as well as apply for Graduate Division travel awards.

SECTION 7. GRADUATE STUDENT SUPPORT

The program plans to support each student with an annual stipend of approximately $21,500 and cover the costs of fees and non-resident tuition for a four year period (our planned normative time to degree). Financial support will include the following:

• First and second year students will be supported primarily by the Graduate Division block grant and campus fellowships, in addition to student initiated fellowship awards and possible support from ministries of health for international students. Second year students may also serve as teaching assistants in MS courses. • Third and fourth year students will be appointed as Graduate Student Researchers and teaching assistants, nominated for appropriate campus fellowships, receive expected GHS gift funds, support from ministries of health, and support from student initiated fellowship awards. It should be noted that many students will be conducting dissertation research abroad and will be eligible for reduced fees through in absentia registration.

Future plans include applying for a T32 NIH training grant when such grants are available for global health doctoral training programs and pursuing discussions with the MSTP Program Director for a possible future slot in this program.

Below is the estimated budget for graduate student support and for the operation of the PhD program. Faculty and staff salaries and benefits, as well as non-payroll expenses will be covered by GHS funds, gifts, and fee income. As mentioned previously, appropriate compensation for courses taken in self-supporting programs are included in the budget, which has been reviewed by the UCSF Budget Office.

Graduate Studies in Global Health Sciences leading to the PhD Degree

2015-16 2016-17 2017-18 2018-19

Enrollment 4 4 8 8

Revenue Source GHS support, gifts, fellowships, GSRs, etc. $ 217,865 $ 208,820 $ 442,478 $ 438,789 Graduate Division Block grant estimate $ 156,552 $ 162,785 $ 167,272 $ 174,029 Total Revenue $ 374,417 $ 371,605 $ 609,750 $ 612,818

Expenses PhD Program Director (.40-.50 FTE) 74,000 76,220 98,133 101,077 Staff Coordinator (.30-.50 FTE) 21,000 21,630 37,132 38,245 Benefits (Director and Staff) 34,930 37,935 54,371 57,395 Payroll subtotal: $ 129,930 $ 135,785 $ 189,636 $ 196,718

Non-payroll Expenses $ 55,919 $ 56,066 $ 63,467 $ 63,680 Supplies, network, travel, curriclum & instruction

Stipends $ 86,000 $ 88,000 $ 176,000 $ 180,000 Resident/ Non-resident Tuition & Fees $ 102,568 $ 91,754 $ 180,647 $ 172,420 Student support subtotal: $ 188,568 $ 179,754 $ 356,647 $ 352,420

Total Expenses: $ 374,417 $ 371,605 $ 609,750 $ 612,818 SECTION 8. CHANGES IN SENATE REGULATIONS

There will be no changes in Senate regulations.

APPENDICES

Appendix 1. Selected Elective Courses

Appendix 2. Bylaws of the PhD Graduate Group in Global Health Sciences

Appendix 3. Letters of Support

Appendix 3a. UCSF Schools

Appendix 3b. UCSF Departments and Programs

Appendix 3c. Other UC Campuses

Appendix 4. Faculty Biosketches

Appendix 1. Selected Elective Courses

Global Health Sciences PhD Elective Courses

GHS Courses GHS 208 - Women's Health and Empowerment GHS 210A - Emerging Topics in Global Health GHS 202F - Strategic Information in Global Health GHS 205 - Global Health Policy—Transforming Evidence Into Action

Epidemiology and Translational Science Courses EPI 213 - Decision and Cost-effectiveness Analysis (3 units) EPI 217 - Molecular and Genetic Epidemiology (3 units) EPI 255 - Social Epidemiology: Concepts and Measures for Studying Social Factors and Health (3 units) EPI 252 - Cancer Epidemiology (3 units) EPI 222 - Health Disparities Research Methods (3 units) EPI 210 - Epidemiology of Aging (3 units) EPI 256 – Environmental and Occupational Epidemiology

School of Nursing – Nursing Science 294A Introduction to Human Genomics (3 units) 291 Applied Statistical Methods For Longitudinal & Hierarcharchical Data (4 units) 289A Advanced Quantitative Research Methods I (4 units) 289B Advanced Quantitative Research Methods II (3 units) 289.01 Advanced Methods: Meta-Analysis (2 units) 285A Qualitative Methods I (5 units) 285B Qualitative Methods II (5 units)

School of Nursing- Sociology 207 Sociology of Health & Medicine (2 - 4 units) 219 Social Policy in Aging (2 - 3 units) 245 Gender, Race & Coloniality 246 Communications & Policy Leadership (3 units) 284 Health Care Economics (4 units) 286 Gender, Sex, & Health (2 - 4 units)

Medical Anthropology 205A Introduction to Sociocultural Theory (4 units) 205B Intro to Sociocultural Theory (4 units) 224 Critical Social Science Case Conference (2 units) 225 Contemporary Issues (2 - 4 units)

History of Health Sciences 223 Medicine, Disease, and Public Health in Modern Latin America (4 units) 255 History of the Social Sciences and Population Health Policy (4 units)

Additionally, we expect that students may choose to take selected courses offered in the 12 Basic Science PhD programs (e.g., Biochemistry and Molecular Biology, Biological and Medical Informatics, Genetics, Neuroscience, Oral and Craniofacial Sciences) may be taken as electives with the approval of the faculty member in charge of the course.

Appendix 2.Bylaws of the UCSF PhD Graduate Group in Global Health Sciences

BYLAWS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHD GRADUATE GROUP IN GLOBAL HEALTH SCIENCES

September 2014

Article I. Purpose

The primary purpose of the PhD Graduate Group in Global Health Sciences (GGGHS) is to establish and administer a graduate program of instruction and research leading to a Ph.D. degree in Global Health Sciences in conformity with the regulations of the Graduate Division of the University of California San Francisco (UCSF).

The PhD GGGHS will provide for the regular assembly of professional personnel involved in this field, assure the maintenance of high standards of performance in instruction and research within its purview, provide Program representation to the university administration and to other organizations, and provide a forum to coordinate interest in global health sciences across the UCSF campus and from other UC campuses. Consequently, the structure and operation of the PhD GGGHS shall be construed broadly enough to permit consideration of all academic aspects of global health and all other appropriate matters affecting the position and progress of the discipline on the UCSF campus.

Article II. Membership

The PhD GGGHS is responsible for the educational policies and the curricula of the academic programs it oversees, and for periodically reviewing the manner in which these policies and curricula are implemented.

Membership criteria will be:

A. Membership in the PhD Graduate Group shall be open to those UCSF and UC faculty members who have an educational, research or service interest in global health and are qualified to supervise graduate students in this area. All GGGHS members must be members of the Academic Senate. B. A person desiring to become a member of the GGGHS shall submit an application to the Executive Committee giving his/her qualifications for membership. Documented interest and experience in global health and a curriculum vitae are required for membership consideration. C. Nominations and applications for membership shall be reviewed and approved by the Executive Committee. If the applicant is not already a member of the UCSF or UC Academic Senate, he/she will additionally have to be approved by appointment to an appropriate academic position within UCSF or a UC Department. D. Membership of the GGGHS shall be reviewed every second year by the Executive Committee. Inactive members may be removed from the membership by a majority vote of the Executive Committee. E. Faculty will be notified of their status in writing annually by the Chair of the Executive Committee. Faculty wishing to have their status reconsidered may appeal to the Executive Committee. A current membership roster shall be maintained on the program website. F. Membership criteria include at least one of the following: 1. Willingness and adequate funding to support the research activities of graduate students. 2. Willingness, expertise and experience in serving on graduate student qualifying exams and dissertation committees. 3. Willingness and expertise to teach a course, seminar, or serve as guest lecturer 4. The ability to accommodate graduate student research projects and experiential learning activities internationally and locally. 5. Attendance and participation in GGGHS retreats or meetings. 6. Willingness to serve in group committee functions.

Article III. Committees and Officers

A. The PhD GGGHS and its activities shall be administered by an Executive Committee consisting of a Chair and four other members. Members of the Executive Committee shall be elected by a majority vote of the Graduate Group, are elected for two-year terms, with the exception of the Chair who will remain on the Committee for the duration of the time necessary to complete the three-year term of that office. Committee members may be re-elected or reappointed. Ex-officio members of the Executive Committee will include the PhD Program Director (voting, ex officio), the GHS Education Director, and the MS Program Director. Individual vacancies on the Executive Committee shall be filled by appointment by the Chair. B. The principal responsibilities of the Executive Committee are: 1. To nominate from among the Executive Committee members a Chair and a Co- Chair. 2. To represent the PhD GGGHS in official matters pertaining to the Graduate Group, both within and outside of the University. 3. To carry on the activities and services of the GGGHS and its academic programs, and encourage further development of the Group. 4. To review, nominate or remove members in the GGGHS in order to maintain an academically active, intellectually stimulating and productive Graduate Group, and to maintain broad and active communications with the GGGHS relevant to the field of Global Health. 5. To establish and maintain liaison with the MS GHS Graduate Group and programs interested in global health at UCSF and on other campuses of the University of California system. 6. To review the PhD academic program and when changes seem desirable, to recommend these to the membership and the Admissions and Curriculum Committees. 7. Appoint such additional standing committee(s) or ad hoc committee(s) as it deems necessary to properly administer the activities of the Group. C. The Admissions Committee shall consist of five members: four faculty members and one graduate student (or recent graduate) appointed by the Executive Committee. The PhD Program Director will be a voting ex-officio member. Initially, appointments will be for one year. Thereafter, individual appointments will be staggered two-year appointments so that 50% of the members are replaced biannually, except for the student representative, who will be a one-year appointment. Members may be reappointed or re- elected. The Admission Committee will have responsibility for the recruitment plan, admissions requirements and process, reviewing applications, and selecting candidates for the program. D. The Curriculum Committee shall consist of five members: four faculty members and one graduate student (or recent graduate) appointed by the Executive Committee. The PhD Program Director and the MS Program Director will be voting ex-officio members. Initially, appointments will be for one year. Thereafter, individual appointments will be staggered two-year appointments so that 50% of the members are replaced biannually, except for the student representative, which will be a one-year appointment. Members may be reappointed or re-elected. The Curriculum Committee will be responsible for the doctoral curriculum, including course content, changes and enhancements to courses, evaluation of courses, and recommending course instructors. E. New Committees may be proposed by the Executive Committee with majority approval of the PhD GGGHS membership.

Article IV. Meetings

A. The Chair shall call such meetings of the GGGHS as are deemed necessary or desirable by him/her or by the Executive Committee. He/she shall call at least one meeting per year. B. The Chair shall call a special meeting of the GGGHS at any time he/she is so requested by written notice of five or more members of the GGGHS. C. At meetings, 30% of the GGGHS membership shall constitute a quorum.

Article V. Amendments

Changes in these By-laws shall be made by approval of both a majority of the Executive Committee and at least two-thirds of the GGGHS membership, either by mail vote or at a meeting, provided that notice of such proposed changes shall have been sent to the members at least one week prior to the date of voting.

Appendix 3. Letters of Support

Appendix 3a. UCSF Schools

University of California San Francisco

School of Pharmacy April 30, 2014

UCSF Box 0622, Rm C152 UCSF Graduate Council 521 Parnassus Ave San Francisco, CA 94143 Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I have reviewed the program proposal for the proposed PhD in Global Health Sciences (GHS) and as the Associate Dean for Global Health in the School of Pharmacy, I am most happy to lend my strong support to this new UCSF PhD. Global health is a growing area of interest within our academic programs and students are eager to pursue more in- depth study in global health. Some of our PharmD students will undoubtedly be interested in pursuing their PhD in global health sciences either while enrolled in our program or after graduation. Additionally, I believe that some of students, who might not choose to pursue a PhD would benefit from coursework within the new GHS PhD program since we are unable to offer the type of coursework offered by GHS. We in turn have been working with GHS on various educational programs in the University of Namibia and in providing classes on the medication supply chain and other medicines- related topics. Thus, the proposed program would benefit not only the School of Pharmacy but also Global Health Sciences in its ability to provide for bi-directional learning.

The integration of UCSF expertise in the health, social, and biological sciences is key to launching a successful PhD program in global health sciences. The program’s design that includes four tracks representing the areas in which UCSF Global Health Sciences (GHS) already has major strengths assures the academic success of the program. The program developers have made the wise decision to limit the number of students to four admitted every other year thus assuring adequate financial resources to fund all students.

Therefore, I am most happy to give support for this new and innovative doctoral program and I look forward to working with the GHS faculty in assisting in the further development of coursework and planning for this exciting new program.

Sincerely,

Tina Penick Brock, EdD Professor of Clinical Pharmacy and Associate Dean for Global Health & Educational Innovations

John S. Greenspan S-612, Box 0422 BSC, BDS, PhD, FRCPath, ScD [hc], FDSRCS [Eng] San Francisco, California 94143-0422 Distinguished Professor of Oral Pathology voice: 415.476. 2220 Department of Orofacial Sciences Associate Dean for Global Health, School of Dentistry assistant: 415.476.1690 Director-Emeritus, AIDS Research Institute, Distinguished Professor of Pathology, School of Medicine fax: 415.514.0395 [email protected]

April 30, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I enthusiastically write to support this proposal for the new degree, Doctor of Philosophy (PhD) in Global Health Sciences at the University of California, San Francisco. Having served on the Global Health Sciences Education Council I am well aware of the proposed PhD program. I commend the initiators of this new PhD program for their interdisciplinary endeavor that will offer new course work in global health, while also providing students access to coursework and professional colleagues in a variety of graduate programs.

I am currently the Associate Dean for Global Health in the School of the Dentistry and am well aware of the growing interest on the part of our dental students and faculty in global health. For example, we have held well attended Global Health and Dentistry conferences every year for the past 4 years—an indication of this growing interest.

The proposed PhD program articulates well with the UCSF integrated DDS/PhD program, a highly competitive program that allows qualified students admission to both the PhD and DDS programs. Some of our students in past years have done joint DDS/PhD programs in dentistry and epidemiology as well as other fields; I believe that some of our students will apply for our funding to complete the DDS/PhD in Global Health Sciences.

In closing, I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities at UCSF.

Sincerely,

John Greenspan

OFFICE OF THE DEAN N-319, Box 0604 April 28, 2014 San Francisco, CA 94143-0604 tel: 415/476-1805 UCSF Graduate Council fax: 415/476-9707 www.ucsf.edu/nursing Academic Senate Office UCSF Box 0764, MUE Room 253

San Francisco, CA 94143

Dear Council Members,

I have reviewed the program proposal for the proposed PhD in Global Health Sciences (GHS). As the Associate Dean and Graduate Program Director for the School of Nursing’s PhD Program, I am most happy to lend my strong support to this new UCSF PhD proposal. Many of our doctoral students in Nursing conduct research that is oriented towards global health, sometimes with data

collection in international settings. The School of Nursing has instituted a global health minor for our masters’ and doctoral students. It is the most popular minor in the school, which is certainly an indication of the strong interest our students have in global health. Our doctoral students would benefit from coursework within the new GHS PhD program since we are unable to offer as broad a choice of global health coursework as is offered by GHS. Likewise, our qualitative methods courses, taught in tandem with the Medical Sociology faculty in Social and Behavioral Sciences, would be most useful to GHS PhD students who will need to develop depth in qualitative methods. Thus, the proposed program would benefit not only the School of Nursing but also Global Health Sciences in its ability to provide for bi-directional learning.

The integration of UCSF expertise in the health, social, and biological sciences is key to launching a successful PhD program in global health sciences. The program’s design includes four tracks representing the areas in which UCSF Department of Global Health Sciences already has major strengths. This assures the academic success of the program. The program developers have made the wise decision to limit the number of students enrolled by planning to admit four students every other year, thus assuring adequate resources to financially support all students.

Although there was originally some concern that a PhD in Global Health Sciences would be competitive to our PhD program in Nursing,

Letter of Support Global Health Sciences PhD Proposal April 28, 2014

after reviewing the proposal I do not believe the two programs would compete with each other, but rather the two programs would be complementary for the reasons outlined above. Therefore, I enthusiastically support this new and innovative doctoral program! I look forward to working with the GHS faculty assisting in the further development of coursework and planning for this exciting new program.

Sincerely,

Judy Martin-Holland, PhD, MPA, RN, CNS, FNP, FAAN Associate Dean for Academic Programs, Graduate Program Director, Interim Director, Masters’ Entry Program in Nursing

Appendix 3b. UCSF Departments and Programs

David O. Morgan PhD FRS Professor and Vice-Chair, Dept. of Physiology Telephone: (415) 476-6695 UCSF MC-2200 Fax: (415) 476-5233 Genentech Hall Room N312B [email protected] 600 - 16th Street http://physio.ucsf.edu/morgan/ San Francisco, CA 94158-2517

August 26, 2014

Molly Cooke, MD, MACP Education Director Global Health Sciences Professor, Department of Medicine

Sally Rankin, RN, PhD, FAAN Faculty Associate Global Health Sciences Professor Emeritus, School of Nursing

Dear Molly and Sally:

We are happy to support your proposal for a new PhD program in Global Health Sciences at UCSF. Your program promises to apply rigorous scientific approaches to the critical problem of global health, and we are excited by the opportunities for collaboration with students in the basic science programs. We look forward to working with you to make this program a success.

Sincerely,

David Morgan, Tetrad Graduate Program, for Patsy Babbitt, Biological and Medical Informatics Program Charles Craik, Chemistry and Chemical Biology Program Jason Cyster, Biomedical Sciences Program Pamela Den Besten and Ralph Marcucio, Oral and Craniofacial Sciences Program Matt Jacobson, Biophysics Graduate Program Deanna Kroetz, Pharmaceutical Sciences and Pharmocogenomics Program Sarah Nelson, Bioengineering Graduate Program Roger Nicoll, Neuroscience Graduate Program Jeremy Reiter, Developmental and Stem Cell Biology Program

April 30, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Graduate Council Members,

We are writing as the Directors of the Masters Program in Global Health Sciences (GHS) at UCSF to enthusiastically support this proposal for the new degree, Doctor of Philosophy (PhD) in Global Health at the University of California, San Francisco. Having discussed the plans for this new program with Drs. Cooke and Rankin, we look forward to the opportunity for the masters and new doctoral program to work together on selected coursework and research projects. The MS program is prepared to integrate doctoral students into our masters coursework with recognition of the need to compensate faculty for the extra time required for doctoral students. We are particularly happy that doctoral students will have the opportunity to develop teaching skills through their work as graduate student instructors in the GHS masters program. We foresee significant collaboration between the doctoral and masters students in the area of the masters students capstone projects as these may evolve from and be related to doctoral dissertation work.

We are enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across our graduate programs. Many of our masters students havean interest in advanced epidemiology and biostatistics and the proposed program provides educational opportunities for our masters students to build depth in these areas by participating in such coursework. Additionally, many of our masters students have expressed interest in further education in global health that would prepare them for academic careers and the proposed doctoral program offers an opportunity for them to enroll in a program that would be tailored to their needs.

We believe this PhD will further advance our working relationships across GHS educational programs and help us embrace interprofessional collaboration and educational activities. Global Health Sciences is by nature interprofessional and the broad spectrum of faculty already teaching in the masters program will be further enhanced by new faculty who will join the PhD program. The uniqueness of global health is its transdisciplinary approach to building sustainable solutions to improve health and eliminate disease.

The development of the PhD in Global Health is timely and helps UCSF address the growing need for qualified faculty in global health and investigators who can contribute to the body of research related to global health. We sincerely hope

this proposal for the PhD in Global Health will be favorably reviewed and we offer our enthusiastic support for the development of this program. We look forward to continued collaboration with this degree program in the future.

Sincerely,

Madhavi Dandu, MD, MPH Director, UCSF MS in Global Health Associate Professor, UCSF School of Medicine

Kimberly Baltzell, RN, MS, PhD Associate Director, UCSF MS in Global Health Assistant Adjunct Professor, UCSF Department of Family Health Care Nursing

Department of Social and Behavioral Sciences

Shari Dworkin, Ph.D., M.S. Professor, Sociology April 30, 2014

Vice-Chair UCSF Graduate Council Department of Social and Behavioral Sciences Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143 Site Address: 3333 California Street Suite 455 Dear Council Members, San Francisco, CA 94118 I am pleased to include this letter of support given that I am indeed enthusiastic about the proposal for Mailing Address: UCSF Box 0612 the new degree, Doctor of Philosophy (Ph.D.) in Global Health Sciences at the University of California, San Francisco, CA 94143-0612 San Francisco. This degree is an interdisciplinary and inter-professional endeavor that will offer new coursework in the diverse areas that comprise the rapidly growing field of global health. As a member of 415.476.9487 (office) 415.476-6552(fax) the faculty teaching in GHS Master’s program (since its inception), I am well aware of the depth and breadth of interest in global health on the part of our Masters’ students and I am quite sure there is an [email protected] equally well prepared cadre of doctoral applicants waiting to apply for the UCSF Ph.D. program. I currently teach a course titled Sociocultural and Behavioral Determinants of Health in the Global Health Sciences MS Program and I look forward to adapting this course for doctoral students. I also look forward to integrating doctoral students from this new program in my own program of research.

I am particularly enthusiastic about the benefits and opportunities that are generated by identifying coursework that can be shared across graduate programs. Many of the Medical Sociology doctoral students in the Department of Social and Behavioral Sciences in the School of Nursing will undoubtedly choose to do some of the coursework in the proposed doctoral program because of their own interest in Medical Sociology and Global Health. We will look forward to integrating doctoral students in theory and methods courses if they wish to gain expertise in these fields through our highly ranked program and well regarded courses. I believe this PhD will further advance our working relationship across programs and help us embrace interprofessional collaboration and educational activities. Additionally, other opportunities for collaboration between the two programs (GHS PhD and Medical Sociology) are plentiful as many of our doctoral students are involved in research related to global health issues and would benefit from further allying themselves with research opportunities in GHS.

Another very important aspect of this proposal that is worth highlighting is the way in which it embraces an integration of UCSF expertise in the health, social, and biological sciences. This is key to launching a successful Ph.D. program in global health sciences. The program design that includes four tracks representing the areas in which UCSF Global Health Sciences (GHS) already has major strengths helps to assure the academic success of the program. The ongoing programs of research in which GHS has traction are important areas for doctoral level dissertations. Additionally, the program directors at GHS have made the wise decision to limit the number of students to four to five admitted every other year thus assuring adequate financial resources to fund all students.

I consider the GHS MS program an incredibly bright light at UCSF and I urge you to seriously consider this proposal for the PhD in Global Health Sciences. I sincerely hope that the proposal will be favorably reviewed and I offer my highest level of support for the development of this program. I look forward to continued collaboration with Global Health Sciences both in the MS and within this new and innovative degree program in the future.

Sincere and best regards, May 1, 2014 Page 2

Shari Dworkin, Ph.D., M.S. Professor

September 11, 2014

To the members of the UCSF Graduate Council: The Global Health Group

Sir Richard Feachem As the Director of the Global Heath Group – one of UCSF Global Health Sciences’ (GHS) KBE, FREng, DSc(Med), PhD, HonDEng Director flagship research groups – and on behalf of the faculty leads of our three signature initiatives, I

50 Beale Street, Suite 1200 write to enthusiastically endorse GHS’ proposal for a doctoral program in Global Health San Francisco, CA 94105, USA tel: 415.597.9276, 415.597.4660 Sciences. We look forward to engaging with future doctoral candidates, as graduate student [email protected] researchers, and ideally as future members of our team.

The Global Health Group is an “action tank,” dedicated to identifying, elaborating and translating innovative solutions to major global health challenges into large‐scale action, to advance health and save lives in low‐ and middle‐income countries. We work across the spectrum, from conducting research and policy analysis, to building consensus, to catalyzing the development and implementation of pioneering programs in collaborating countries. Our activities are focused under three core initiatives: the Malaria Elimination Initiative, which provides guidance and support to 34 countries to achieve their elimination goals, the Private Sector Healthcare Initiative, which seeks to understand and strengthen delivery of care by formal and informal private sector actors, and the Evidence to Policy Initiative, which synthesizes best evidence to inform the policies and decisions of donor and country leaders to improve financing and delivery of care.

Since our founding in 2007 we have raised over $53M in sponsored research funding, primarily from non‐federal sources including the Bill & Melinda Gates Foundation, ExxonMobil, the Novartis Foundation for Sustainable Development, the Rockefeller Foundation, and recently a $2M contract from the US Navy. Additional 3‐year funding is anticipated later this fall.

Since the inception of the highly successful GHS Master’s Degree program in 2008, our faculty have made meaningful contributions to the program through teaching, advising and mentoring. Our faculty and research staff regularly sponsor and mentor 6‐8 students per year during their field work and capstone projects, and we have been pleased to hire 13 students to date, both during their program and full time after their graduation. Our ongoing success will be enhanced by a strong cadre of doctoral‐level global health students. We look forward to being actively involved in their recruitment, and as funding and alignment of research interests permit, support their training and longer term career development.

Thank you for your consideration of GHS’ PhD proposal. Please don’t hesitate to contact me if I can provide any additional background.

With best regards,

Sir Richard Feachem, KBE, FREng, DSc(Med), PhD Director, The Global Health Group Professor of Global Health

University of California San Francisco

Department of Epidemiology & Biostatistics China Basin Landing

May 2, 2014 M. Maria Glymour, S.D.

Associate Professor UCSF Graduate Council Department of Epidemiology & Biostatistics Academic Senate Office Director, Epidemiology and UCSF Box 0764, MUE Room 253 San Francisco, CA 94143 Translational Science PhD Program Dear Council Members,

University of California, I write to express my enthusiastic support this proposal for the new degree, Doctor of Philosophy (PhD) in Global San Francisco Health Sciences here at the University of California, San Francisco. As director of the Epidemiology & Translational UCSF Box 0560 Science PhD program, I anticipate the new Global Health PhD program will strengthen the university, enrich our 185 Berry Street, Lobby 5 Suite 5700 existing training, and complement the Epidemiology & Translational Science PhD. The global health PhD degree is an San Francisco, CA 94107 interdisciplinary and interprofessional endeavor that will offer new coursework in the diverse areas that comprise the important and growing field of global health. Doctoral students in the new PhD program in Global Health will take 415/514-8014 tel [email protected] epidemiology and biostatistics courses with our Epi students and likewise our Epi students will avail themselves of advanced coursework in Global Health Sciences. Additionally, there may be opportunities for our faculty to obtain some salary support if they develop and teach courses in the new program.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across graduate programs. Many doctoral students in various UCSF PhD program have an interest in global health and the proposed program provides educational opportunities for all doctoral students at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities. Additionally, opportunities for collaboration between the two programs (GHS PhD and Epi PhD) are manifold as many of our doctoral students are involved in research related to global health problems. Epidemiologic tools are often the cornerstone of global health research, so the programs are conceptually synergistic. Creating a rich intellectual community for students to engage and learn from one another is a key goal for our training activities, and I anticipate the GHS PhD program, by attracting top notch students with deep and serious commitments to improving global health, will foster that goal.

The program’s design includes four tracks representing the areas in which UCSF Global Health Sciences (GHS) already has major strengths; building on these existing assets assures the academic success of the program. The ongoing programs of research in which GHS has traction are important areas for doctoral level dissertations. Additionally, the program directors have considered how to handle each year’s cohort size in a way to assure adequate financial resources to fund all students.

I sincerely hope this proposal for the PhD in Global Health Sciences will be favorably reviewed and I offer my enthusiastic support for the development of this program. I look forward to continued collaboration with this degree program in the future.

Sincerely,

Dr. M. Maria Glymour Associate Professor and Program Director, PhD Program in Epidemiology and Translational Science

University of California San Francisco

Department of Epidemiology & Biostatistics China Basin Landing

Robert A. Hiatt, MD, PhD May 20, 2014

Professor and Chair, Department of Epidemiology UCSF Graduate Council & Biostatistics Academic Senate Office Director of Population Sciences and Associate Director, Helen UCSF Box 0764, MUE Room 253 San Francisco, CA 94143 Diller Family Comprehensive Cancer Center Dear Council Members, University of California, San Francisco I write to offer my enthusiastic support this proposal for the new degree, Doctor of Philosophy UCSF Box 0560 185 Berry Street (PhD) in Global Health Sciences at the University of California, San Francisco. This degree is an Lobby 5, Suite 5700 interdisciplinary and interprofessional endeavor that will offer new coursework and perspectives San Francisco, CA 94107 in the diverse areas that comprise the new and growing field of global health.

415/514-8113 tel 415/514-8150 fax As the Chair of Epidemiology and Biostatistics I am aware of the potential complementarity of our [email protected] two programs. We offer advanced epidemiology and biostatistics courses and training in population health important for your students in the new PhD program in Global Health; our graduate students will be able to avail themselves of advanced coursework in Global Health Sciences. I am particularly interested in supporting new coursework that addresses complex global and population health problems that can be shared by both graduate programs. Many doctoral students in various UCSF PhD program have an interest in global health and the proposed program provides educational opportunities for all doctoral students at UCSF who are interested in enrolling in courses in these subject areas. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities as well as training in transdisciplinary approaches to new knowledge generation. Already opportunities for collaboration between the two programs (GHS PhD and Epidemiology & Translational Science PhD) are manifold as many of our doctoral students are involved in research related to global health problems.

The integration of UCSF expertise in the health, social, and biological sciences is key to launching a successful PhD program in global health sciences. The program’s design that includes four tracks representing the areas in which UCSF Global Health Sciences (GHS) already has major strengths assures the academic success of the program. The ongoing programs of research in which GHS has traction are important areas for doctoral level dissertations. Additionally, the program directors have made the wise decision to limit the number of students to four to five admitted every other year thus assuring adequate financial resources to fund all students.

Sincerely,

Robert A. Hiatt, MD, PhD Professor and Chair Department of Epidemiology and Biostatistics

Department of Social and Behavioral Sciences

Janet K. Shim, PhD , MPP April 23, 2014 Associate Professor Director, Doctoral Program in Sociology UCSF Graduate Council

Tel: (415) 476-9392 Academic Senate Office Fax: (415) 476-6552 UCSF Box 0764, MUE Room 253 Email: [email protected] San Francisco, CA 94143 UCSF Box 0612 3333 California Steet, Suite 455 San Francisco, CA 94143-0612 Dear Council Members:

I have reviewed the program proposal for the proposed PhD in Global Health Sciences , and as the Director for the Doctoral Program in Sociology, I am most happy to lend my strong support to this new UCSF PhD program . Many of our doctoral students in Sociology conduct research that i s oriented towards global health, often involving data collection in international settings. I believe that some of these students wo uld benefit from coursework in the new PhD program. Likewise, some of our courses would be of interest to students enrolled in the Global Health Sciences program .

The integration of UCSF expertise in the health, social, and biological sciences is key to launching a successful PhD program in global health sciences. The program’s design that includes four tracks representing the areas in which UCSF Global Health Sciences (GHS) already has major strengths assures the academic success of the program. The ongoing programs of research in which GHS has tra ction are important areas for doctoral level dissertations. Additionally, the program directors have made the wise decision to limit the number of students to four to five admitted every other year thus assuring adequate financial resources to fund all stu dents.

Given the possibilities for collaboration at t he faculty and student levels between a GHS PhD program and the Sociology program, and the important niche that this new and innovative program would fill, I am most happy to give support for a PhD program in Global Health Sciences and I look forward to working with the GHS faculty in assisting in the further development of coursework and planning for this exciting new program.

Sincerely,

Janet K. Shim, PhD, MPP Associate Professor of Sociology Directo r, Doctoral Program in Sociology University of California San Francisco

Department of Anthropology, History and Social Medicine

3333 California Street Suite 485 San Francisco, CA 94143-0850 tel: 415/476-7234 fax: 415/476-6715 April 28, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I write to support the proposal for the new degree, Doctor of Philosophy (PhD) in Global Health Sciences at the University of California, San Francisco. As the Program Director of the UCSF side of the joint UCSF-UCBerkeley PhD Program in Medical Anthropology I commend the initiators of this new PhD program for their interdisciplinary endeavors that will offer new course work in global health, while also providing students access to coursework and professional colleagues in a variety of graduate programs, such as Epidemiology, Medical Anthropology, Medical Sociology, Nursing, and Biomedical Sciences by allowing them to choose a curriculum tailored to their needs.

As the program director of the Medical Anthropology program, I am aware that faculty from my group, myself included, have been heavily involved in the MS in Global Health Sciences and they have worked with faculty at Global Health Sciences to develop clinical and teaching programs for GHS students. Additionally, we have provided faculty to the masters program in global health sciences and will continue to do this; we look forward to the inclusion of doctoral students in the appropriate courses. We do not foresee that our PhD program will be threatened by the new PhD in GHS because our foci are so different and our students want greater depth in the social sciences than will your students. Therefore, there are no territorial issues and we look forward to working together as you further develop the course content.

The goals of this new program are in line with the vision and mission of UCSF, and this new program offers opportunity for collaboration across the University. I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across graduate programs. I believe this PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities. Sincerely,

Ian Whitmarsh, Ph.D. Associate Professor Director, Medical Anthropology Ph.D. Program Department of Anthropology, History, and Social Medicine University of California, San Francisco [email protected] (415) 476-6164

Appendix 3c. Other UC Campuses

May 21, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I am pleased to learn that UCSF Global Health Sciences is moving forward with its plans to initiate a PhD in Global Health. The University of California system has major strengths at most UC campuses in global health, but none of the campuses have yet developed a PhD that is exclusively oriented to global health sciences. This degree, an interdisciplinary and interprofessional endeavor, will offer new coursework in the diverse areas that comprise the new and growing field of global health. As such it will prepare faculty to join academic institutions in academic and research positions. As the Director of the UCLA Center of World Health in the School of Medicine, I am well aware of the depth and breadth of interest in global health on the part of California undergraduate, graduate, and professional degree students and I am sure that many of them will be attracted to the UCSF PhD program.

I am particularly enthusiastic about the benefits and opportunities generated by identifying coursework that can be shared across graduate programs, especially through the mechanisms offered by the University of California, Global Health Institute (UCGHI), for which I am the co-Executive Director with Dr. Haile Debas. Having been the co-founder of the UCSF Center for AIDS Prevention Studies (CAPS) and the founding Executive Director of the UCSF AIDS Research Institute I am aware of the many and varied resources at UCSF and the complementary resources at UCLA. I believe this new PhD will further advance our working relationships across programs and help us embrace interprofessional collaboration and educational activities.

We look forward to sending some of our students to UCSF and hope that there will be opportunities for our UCLA World Health center, UCGHI, and the new program at UCSF to collaborate. Global health is a rapidly growing discipline and the proposed program at UCSF benefits all of us. I sincerely hope this proposal for the PhD in Global Health Sciences will be favorably reviewed and I offer my enthusiastic support for the development of this program.

Sincerely,

Thomas J. Coates, PhD Distinguished Professor of Medicine Michael & Sue Steinberg Endowed Professor of Global AIDS Research Director, Center for World Health David Geffen School of Medicine & UCLA Health University of California, Los Angeles

10833 Le Conte Avenue, CHS 12-105 Los Angeles, CA 90095 (310) 825-2440 UNIVERSITY OF CALIFORNIA, DAVIS

BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO SANTA BARBARA SANTA CRUZ

SCHOOL OF VETERINARY MEDICINE ONE SHIELDS AVENUE DEPARTMENT OF VETERINARY PATHOLOGY, DAVIS, CALIFORNIA 95616-8739 MICROBIOLOGY AND IMMUNOLOGY TELEPHONE (530) 752-1385 FAX (530) 754-8124

May 22, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members,

I am pleased to learn that UCSF Global Health Sciences plans to initiate a PhD in Global Health Sciences, which will capitalize on the many strengths of UCSF, as well as help advance the overall profile of the University of California as a leader in this growing field. This proposed degree, an interdisciplinary and interprofessional endeavor, will offer new coursework and research opportunities in the diverse areas that comprise global health. As such, it will prepare faculty to join academic institutions in teaching and research positions, as well as train future leaders in global health. As the Associate Dean for Global Programs in the UC Davis School of Veterinary Medicine and co-director of the UC Global Health Institute, One Health Center of Expertise: Water, Animals, Food and Society, I am well aware of the strong interest in global health on the part of students, postdoctoral scholars, and faculty members across the UC system.

I am particularly enthusiastic about the benefits and opportunities generated by identifying course-work and other training opportunities that could be shared across our programs. At UCD we offer a Masters in Public Health, Masters in Preventive Veterinary Medicine, and Masters in International Agricultural Development. In addition, we hope to launch an undergraduate Major/Minor in Global Disease Biology in the fall of 2014. Our programs could serve as a pipeline for each other and the complementary resources and geographic locations of UCSF and UCD have the potential to advance our working relationships across programs.

We look forward to opportunities for our educational programs to collaborate as global health is a rapidly growing discipline and the proposed program at UCSF benefits all of us. I sincerely hope this proposal for the PhD in Global Health Sciences will be favorably reviewed and I offer my enthusiastic support.

Sincerely,

Patricia A. Conrad, DVM, PhD Associate Dean for Global Programs School of Veterinary Medicine University of California, Davis

Co-Director, One Health Center University of California Global Health Institute

Steffanie Strathdee, PhD 9500 Gilman Drive, MC-0507 Harold Simon Professor La Jolla, California 92093-0507 Associate Dean of Global Health Services (858) 822-1952 Fax (858) 534-7566 Chief, Division of Global Public Health E-Mail: [email protected] Director, UCSD Global Health Initiative University of California San Diego School of Medicine

May 16, 2014

UCSF Graduate Council Academic Senate Office UCSF Box 0764, MUE Room 253 San Francisco, CA 94143

Dear Council Members:

I am pleased to learn that UCSF Global Health Sciences is moving forward with its plans to initiate a PhD in Global Health Sciences. The University of California system has major strengths at many UC campuses in global health, including the educational and training programs offered at UC San Diego. This proposed degree, an interdisciplinary and inter-professional endeavor, will offer new coursework and research opportunities in the diverse areas that comprise the growing field of global health. As such, it will prepare faculty to join academic institutions in teaching and research positions, as well as train future leaders in global health. As the Associate Dean of Global Health in the UCSD Department of Medicine, member of the Leadership Committee of the UC Global Health Institute, and co-PI of the NIH Fogarty GloCal Fellowship Program with Craig Cohen, I am well aware of the depth and breadth of interest in global health on the part of undergraduate, graduate and professional degree students, and postdoctoral scholars.

I am particularly enthusiastic about the benefits and opportunities generated by identifying course work and other training opportunities that could be shared across our programs. At UCSD we offer a joint PhD with San Diego State University in Public Health with a global health concentration, an undergraduate minor in global health, and a newly approved undergraduate major in global health. Our undergraduate programs could serve as a pipeline for the new PhD program and the complementary resources of UCSF and UCSD have the potential to advance our working relationships across programs.

We look forward to sending some of our students to UCSF and hope that there will be opportunities for our educational programs to collaborate. Global health is a rapidly growing discipline and the proposed program at UCSF benefits all of us. I sincerely hope this proposal for the PhD in Global Health Sciences will be favorably reviewed and I offer my enthusiastic support.

Sincerely,

Steffanie Strathdee, PhD Associate Dean of Global Health Sciences Harold Simon Professor and Chief of the Division of Global Public Health University of California, San Diego

Appendix 4. Faculty Biosketches

Vincanne Adams, PhD Curriculum Vitae

CURRENT POSITION Professor and Vice Chair Department of Anthropology, History and Social Medicine School of Medicine University of California San Francisco

EDUCATION 1989 University of California, Berkeley and UCSF PhD, Medical Anthropology 1982 Brown University, Providence, RI BA, Biology

PRINCIPAL POSITIONS HELD 2000-pres Associate and Full Professor, Dept. of Anthropology, History and Social Medicine, University of California, San Francisco 1992-1999 Assistant and Associate Professor, Department of Anthropology, Princeton University

HONORS, AWARDS, RECOGNITIONS 2014 Finalist, C. Wright Mills Prize (for Markets of Sorrow, Labors of Faith) 2009 Winner of the Basham Medal, presented by the International Association for the Study of Traditional Asian Medicine, at the ICTAM VII Congress in Thimpu Bhutan 2009 Nominee and runner up for President of Society for Medical Anthropology, American Anthropological Association. 2006 Polgar Prize, Society for Medical Anthropology (awarded to best article appearing in flagship journal MAQ over a two year period) 2006 Nominee: Outstanding Faculty Membership Award 2000 Winner of the YuThog Cup Award, Lhasa 2000 Conference on Tibetan Medicine, Minority Medical Association of China, Lhasa TAR, PRC.

RESEARCH ACTIVITIES Major Fieldwork: 2010-pres Metrics of the Global Sovereign: Evidence and Efficacy In Global Health 1982-pres Modernization and Trauma in Tibet 2007-pres Disaster Recovery in Post-Katrina New Orleans 2006-2010 Voluntary Blood Donation and HIV Prevention in China (Shanghai) 2001-2005 Safe Motherhood and Women’s Health in Tibet 2000 Tibetan Medicine and Modernization in Lhasa, TAR. 1990-1996 Nepalese Physicians and Democratic Revolution, Medical Science and Social Change (International Health, Science Studies). 1986-1989 Medical Pluralism and Social Change among Sherpas of Nepal (Ethnographic Theory, Tourism, Medical Knowledge and Ritual)

1 PROFESSIONAL ACTIVITY 2013-pres Vice Chair, Department of Anthropology, History and Social Medicine 2012 Interim Chair, Department of Anthropology, History and Social Medicine 2000-2012 Director, Graduate Program in Medical Anthropology, UCSF (joint program with UC Berkeley) 1992-1999 Director, Graduate Program in Anthropology, Princeton University

Administrative Service (since 2000) 2012- Global Health Sciences Education Development Committee, UCSF 2010-pres Pacific Rim Research Award Committee, UCSF 2006-pres Center for Science, Technology and Medicine Studies, UC Berkeley 2006 -pres Institute on Global Conflict and Cooperation, Campus Program Director or Steering Committee Member (excluding 2012-2013) 2000-2011 Faculty in-charge, Medical Anthropology Departmental Colloquium 2006-2011 Global Health Sciences Curriculum Development Committee, UCSF 2003-2010 Deans Research Prize Committee, UCSF 2003-2004 Chancellor’s Advisory Committee on the Status of Women, UCSF 2003-2006 Pathways to Discovery SOM Task Force, UCSF 2005-2008 Medical Humanities Area of Concentration, co-director, UCSF 2000-2004 Center for Health and Community, Steering Committee, DAHSM, UCSF 2000-2001 Culture in the Curriculum, Development Committee, UCSF 2000-2001 Brain, Mind and Behavior Block, Development Committee, UCSF 2000-2003 UC Humanities Research Institute, Advisory Board, UCI

EXTRAMURAL FUNDING (5 years only) Age, Disruption and Life Reorganization after Hurricane Katrina NIH(NIA) R01 AB028621 PI: Adams, V $1,203,840 6/07-5/12 Blood Donation and HIV Prevention in China NIMH R21 PI: Adams, V $336,643 3/06-2/09 Science and Morality in Tibet: Research Across Cultures PI: Adams, V $79,404 1/06-4/09 PUBLICATIONS BOOKS, Peer-Reviewed Adams, V. PreOccupied: Writing In-The-Gap About Tibet (under review, Duke). Adams, V. ed. Metrics, Global: Numbers and Stories in Global Health (under review, Duke) Adams, V. Markets of Sorrow, Labors of Faith: New Orleans in the Wake of Katrina Durham: Duke University Press 2013. (excerpted in The Utne Reader (no. 179, Sept.- Oct. 2013, interviews with BBC “Thinking Allowed” and with Peter Collins Radio, finalist C. Wright Mills Prize). Adams, V., Schrempf, M. and Craig, S., eds., Medicine Between Science and Religion: Explorations on Tibetan Ground London: Berghahn Publishers 2010.

2 Adams, V. and S.L. Pigg, eds., Sex and Development: Science, Sexuality and Morality in Global Perspective Durham: Duke University Press 2005. Adams, V. Doctors for Democracy: Health Professionals in the Nepal Revolution Cambridge University Press (Series in Medical Anthropology), 1998. Adams, V. Tigers of the Snow and Other Virtual Sherpas: An Ethnography of Himalayan Encounters Princeton University Press, 1996.

ARTICLES AND CHAPTERS, Peer-Reviewed (Selective list, since 2008 only) Adams, V. “Tibet on Fire” In Veena Das and Clara Han, eds. An Anthropology of Living and Dying in the Contemporary World, Universitiy of California Press (in press). Adams, V. “The Poverty Factory” to appear in Ananya Roy and Emma Shaw Crane, eds, Territories of Poverty, University of California Press (in press). Adams, V. “Evidence of the Tibetan Body: Making the Subtle Winds Visible in an Evidence Economy” Pordie, L. ed. Volume Asia and Europe in Global Perspective (in press). Adams, V., I. Whitmarsh and N. Burke “Slow Research: Thoughts for A Movement in Global Health” Medical Anthropology 33(4) 2014. Adams, V. “A History of International Health Encounters: Diplomacy in Transition” in T. Novotny and I. Kickbusch, eds, Global Health Diplomacy 2013. Adams, V. “Evidence Based Global Public Health: Subjects, Profits, Erasures” in J. Beihl and A. Petryna Editors When People Come First Princeton University Press, 2013. Adams, V. “The Other Road to Serfdom: Recovery by the Market and the Affect Economy in New Orleans” Public Culture 24(1):185-216, 2012. Adams, V. "Encounters with Efficacy” Journal of Asian Medicine 6:1-21, 2011. Adams, V. T. VanHattum, S. Kaufman and S. Moody-Ayers "Aging Disaster: Mortality, Vulnerability, Resilience and How Age Matters over the Long Term among Katrina Survivors" Medical Anthropology 30(3):247-270, 2011. Adams, V. and S. R. Kaufman "Ethnography and the Making of Modern Health Professionals" Culture, Medicine and Psychiatry 35(2):313-320, 2011. Adams, V., K. Erwin, and P.V.Le "Governing through Blood: Biology, Donation and Exchange in Urban China" in A. Ong, and N. Chen, eds., Asian Biotech: Bioeconomics and Communities of Fate. Duke University Press 2010. Adams, V. "Against Global Health? Arbitrating Science, Non-Science and Nonsense Through Health" in Jonathan Metzl Anna Kirkland eds., Against Health:How Health Became a New Morality NYU Press pp.40-60, 2010. Adams, V, R Dongzhu, and P.V. Le "Translating Science: The Arura Medical Group at the Frontiers of Medical Research" In S. Craig, M. Cuomu, F. Garrett, and M. Schrempf eds., Studies of Medical Pluralism in Tibetan History and Society International Institute for Tibetan and Buddhist Studies, pp.111-136, 2010. Adams, V., T. VanHattum, and D. English "Chronic Disaster Syndrome: Displacement, Disaster Capitlaism and the Eviction of the Poor from New Orleans" American Ethnologist 26(4): 615-636, 2009. Adams, V., A. Clarke and M. Murphy "Anticipation: Technosciene, Life, Affect and Temporality" Subjectivities 28: 246-265, 2009. Adams, V., K. Erwin, and P.V.Le "Public Health Blood Donation in Urban China" Social Science and Medicine 68(2009): 410-418. Adams, V., T. Novotny, H. Leslie "Global Health Diplomacy" Medical Anthropology 12(4):315- 323, 2008.

3 Adams, V. "Modernity and the Problem of Secular Morality in Tibet. In Vincent Houben and Mona Schrempf, eds., Figurations of Modernity: Global and Local Representations in Comparative Perspective Frankfurt: Campus Verlag 2008: 105-120.

Principal Investigator/Program Director (Last, First, Middle): Baltzell, Kimberly A.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Baltzell, Kimberly A. Assistant Adjunct Professor, Department of Family eRA COMMONS USER NAME Health Care Nursing/Associate Director, MS in Baltzell Global Health Science, Department of Global Health EDUCATION/TRAINING (Begin with baccalaureate or other initial professionalSciences education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) St. Mary’s College of Maryland, St. Mary’s City, B.A. 1975-1979 English UniversityMD of Pennsylvania, Philadelphia, PA N/A 1987-1988 Nursing University of San Francisco, San Francisco, CA B.S.N. 1989-1991 Nursing University of California San Francisco, CA Ph.D. 2001-2005 Nursing University of California San Francisco, CA M.S. 2009-2010 Global Health Science

A. Personal Statement My program of research has focused on malaria and non-malarial fevers in sub- Saharan Africa. As part of this research program, I have conducted qualitative studies to explore how health workers make diagnostic decisions in resource limited settings. Additional, as Associate Director of the MS in Global Health Sciences at UCSF, I have developed and supervised multiple qualitative and quantitative studies of graduate students in topics ranging from HIV risk in men in Malawi to perception of malaria risk.

B. Positions and Honors Positions and Employment 1981-1984 Account Executive, Dean Witter Reynolds, Philadelphia, PA 1984-1989 Vice President, Sales, Smith Barney, Philadelphia, PA 1989-1991 Nursing Student, University of San Francisco, San Francisco, CA 1992-1998 Clinical Nurse II, University of California San Francisco, San Francisco, CA 1999-2001 Volunteer R.N., San Francisco Free Clinic, San Francisco, CA 2004-2006 Clinical Nurse III, University of California San Francisco, San Francisco, CA 2006-present Assistant Adjunct Professor, University of California San Francisco 2010-2013 Faculty Associate, Department of Global Health Sciences, University of California San Francisco 2013-present Associate Director, MS in Global Health Sciences, University of California San Francisco 2014-present Director, UCSF School of Nursing International Programs & Global Health

Professional Memberships 2001-present Member, Sigma Theta Tau International 2002-present Member, Oncology Nursing Society 1996-2004 Founding Board Member, Sarcoma Alliance 2006-present Founder, NetGain-Malawi 2008-2012 Board Member, Global AIDS Interfaith Alliance 2009-present Board Member, The Milagro Foundation 2009-2012 Chair, Strategic Planning Committee, Global AIDS Interfaith Alliance 2010-present Malaria Program Director, Global AIDS Interfaith Alliance 2013-present Member, American Academy of Nursing 2014-present Fellow, American Academy of Nursing

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page

C. Selected peer-reviewed publications (in chronological order). Baltzell K, Eder S, Wrensch M. Breast carcinogenesis: can the examination of ductal fluid enhance our understanding? Oncol Nurs Forum. 2005 Jan 19;32(1):33-39

Baltzell K, Wrensch MR. Strengths and limitations of breast cancer risk assessment. Oncol Nurs Forum. 2005 May 10;32(3):605-16

Baltzell K, Wrensch MR, Sison J. A descriptive study of variables associated with obtaining nipple aspirate fluid in a cohort of non-lactating women. BMC Women’s Health, 2006, 6(15).

Baltzell K, Moghadassi M, Rice T, Sison J, Wrensch MR. Epithelial cells in nipple aspirate fluid and subsequent breast cancer risk: a historic prospective study. BMC Cancer, 2008, 8:75.

Baltzell K, Shen H. & Buehring G. Oncogenic viruses in nipple aspirate fluid: biomarkers for breast cancer risk assessment? BMC Proceedings 2009, 3(Suppl 5):S4

Baltzell K, Buehring G, Krishnamurthy S, Kuerer H, Shen H, Sison J. Limited evidence of human papilloma virus in breast tissue using molecular in situ methods, Cancer, 2011, doi: 10:1002/cncr.26389.

Baltzell K, Buehring G, Krishnamurthy S, Kuerer H, Shen H, Sison J. Epstein-Barr virus is seldom found in mammary epithelium of breast cancer tissue using in situ molecular methods, Breast Cancer Research and Treatment, 2012, 132(1):267-74.

Shakely D, Elfving K, Morris U, Aydin-Schmidt B, Jornhagen L, Ferreira PE, Ali AS, Msellem MI, Petzold M, Baltzell K, Greenhouse B, Bjorkman A, Martensson A. Effectiveness of malaria rapid diagnostic tests in fever patients attending primary health care facilities in the context of low malaria transmission in Zanzibar. Tropical Medicine & International Health, 2011,16: Supp 1,140.

Baltzell K, Shakely D, Hsiang M, Kemere J, Ali A, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal P, Greenhouse B. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar, American Journal of Tropical Medicine & Hygiene, 2013 Feb;88(2):289-91.

Baltzell K, Elfving K, Shakely D, Ali AS, Msellem M, Gulati S, Mårtensson A. Febrile illness management in children under five years of age: a qualitative pilot study on primary health workers’ practices in Zanzibar, Malaria Journal, 2013, 12(1); 37.

Bauch J, Gu J, Msellem M, Mårtensson A, Ali AS, Gosling R, Baltzell K. Perception of malaria risk in a setting of reduced malaria transmission: a qualitative study in Zanzibar, Malaria Journal, 2013, 12:75.

Shakely D, Elfving K, Schmidt B, Msellem M, Morris U, Omar R, Xu W, Petzold M, Greenhouse B, Baltzell K, Ali A, Björkman A, Mårtensson A. The usefulness of rapid diagnostic tests in the new context of low malaria transmission in Zanzibar, PLoS ONE, 2013, 8(9): e72912. doi: 10.1371/journal.pone.0072912: PMID: 24023791

Dial NJ, Ceesay SJ, Gosling RD, D'Alessandro U, Baltzell KA. A qualitative study to assess community barriers to malaria mass drug administration trials in The Gambia, Malaria Journal, 2014, Feb 4;13:47. doi: 10.1186/1475-2875-13-47. PMID: 24495715

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Baltzell, Kimberly A.

D. Research Support. Ongoing Research

Bill & Melinda Gates Foundation #A122394 (Co-investigator) 1/14 – 12/16 Accelerating Progress on Elimination

The specific aims of this study are to compare reactive case detection in malaria index cases with total parasite elimination in Swaziland.

Avon Foundation Grant #02-2011-103 (PI) 1/12 – 12/14

The specific aims of this study of 150 women without breast cancer are 1) to determine if HPV and BLV play a role in the cause and progression of breast cancer during early nonmalignant stages and compare the frequency of virus markers in high risk versus low risk forms of nonmalignant pathology classifications and 2) to determine the potential utility of NAF cells to serve as a non-invasive surrogate measure of the presence of HPV and BLV within nonmalignant breast tissue.

Completed Research

Department of Defense #DAMD17-03-1-0354 (PI) 6/03 – 6/05 Exploring Early Detection Methods: Using the Intraductal Approach to Predict Breast Cancer

This historic prospective cohort study followed a cohort of breast clinic patients to the present, determining vital status and breast cancer incidence, statistical models of the association were constructed between categories of breast fluid cytology measurement and breast cancer incidence.

Dr. Susan Love Research Foundation Pilot Grant (co-PI) 3/07 – 3/09 Oncogenic Viruses in Nipple Aspirate Fluid: Biomarkers for Breast Cancer Risk Assessment?

The specific aims of the study are: 1) to determine the feasibility of detecting BLV, EBV, and HPV in NAF and NAF cells by different types of polymerase chain reaction (PCR) methods 2) to determine if these viruses are present more frequently in women with a history of breast cancer versus those with no history.

Avon Foundation Grant #07-2007-073 (PI) 1/08 – 6/10 Viruses in Breast Fluids: Biomarkers for Breast Cancer Risk?

The aims of this study are 1) to perfect the technique of using in situ polymerase chain reaction (PCR) to detect bovine leukemia virus (BLV), Epstein-Barr virus (EBV) and human papilloma virus (HPV) in nipple aspirate fluid (NAF) cells and fluid 2) to compare breast tumor and non-neoplastic tissue and NAF from the same subject for the presence of BLV, EBV and HPV and 3) to compare both breast tissue and NAF specimens from the diseased and contralateral breast of the same subject for evidence of BLV, EBV and HPV.

Milagro Foundation (PI) 2/09-2/10 NetGain-Malawi – Universal bednet distribution project

Bill and Melinda Gates Foundation Grand Challenges Exploration (co-investigator) 3/10-3/11 PlasmoTrack: Spatiotemporal Tracking of Malaria Parasites for Malaria Elimination

The goal of this research is to test a novel system that utilizes molecular and computational tools to track individual malaria parasites across space and time to determine whether a parasite is locally transmitted or imported, and from where the parasite originated. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Baltzell, Kimberly A.

Milagro Foundation (PI) 2/10-2/11 Netgain-Malawi – Universal bednet distribution project

The goal of this project was to distribute over 200,000 insecticide-treated bed nets in southern Malawi to residents without access to health care facilities. Nets were provided by The Global Fund for HIV, TB and Malaria.

ACT Consortium #ITGB5170/KI (field coordinator) 3/11-8/11 Infectious disease etiologies of uncomplicated febrile illness in children <5 years of age in rural Zanzibar

The goal of this project was to study infectious disease etiologies in uncomplicated febrile illness in children 2- 59 months seeking care at primary health care centers in Zanzibar and to assess how RDT incorporated in the IMCI guidelines identifies ACT- and antibiotic requiring patients.

Center for AIDS Research – University of California San Francisco (PI) 9/11 – 9/12 Provider Practices with Childhood Non-Malarial Fevers: A Pilot Study in Zanzibar

The specific aims of this mixed methods study are: 1) to determine the specific diagnoses and treatments assigned by health care providers to febrile patients under the age of 5 in clinics in Zanzibar and 2) to characterize health care provider practices leading to the diagnosis and treatment of febrile patients under the age of 5 in Zanzibar.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Brindis, Claire D. Professor of Pediatrics and Health Policy; eRA COMMONS USER NAME (credential, e.g., agency login) Director, Philip R. Lee Institute for Health Policy Brindis Studies EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Los Angeles, CA BA 1972 Sociology, Cum Laude University of California, Los Angeles, CA MPH 1973 Maternal/Child Public Health/Behavioral University of California, Berkeley, CA DrPH 1982 Sciences

A. Personal Statement

My research focuses on young adult, adolescent, and child health policy, and topics related to adolescent health and risk-taking behaviors, social, health, and economic disparities among a wide variety of sub-groups of adolescents, and multi-method evaluations of health interventions aimed at ameliorating the impact of social and health disparities. My research has examined health and economic disparities among multi-ethnic/racial groups nationally, including in health insurance coverage, risk taking behaviors, including teenage pregnancy, as well as issues such as suicide, substance use, and other health outcomes, in addition, I have special expertise on Latino/a diverse populations, global reproductive health, migration and health, as well as examining the impact of migration and acculturation on Latina/o immigrants. I have served on the Steering Committee of the University of California, Global Health Initiative’s Center of Expertise on Migration and Health (COEMH) (being one of the co-founders with colleagues at UCSD, UCLA, and UC Irvine) and the Center of Expertise on Women’s Health and Empowerment (also a co-founder), serving as a liaison between both groups. Among my publications are three reports, which I have co-authored: “Creating a Health Research and Policy Agenda for Immigration Between Mexico and California”, and “Migration and Health: Mexican Immigrant Women in the U.S.” and “A Health Profile of Immigrant Teenagers”, representing a multi-campus, cross-border collaboration between the National Population Council of the Government of Mexico (CONAPO), UCB School of Public Health Initiative of the Americas (ISA), UCLA School of Public Health, UC, Davis and UC Berkeley Migration and Health Research Center (MAHRC), and UCSF’s Bixby Center for Global Reproductive Health (I am one of the co-Directors). In addition, I bring particular expertise in the translation of research findings into policy and its dissemination to a wider variety of stakeholders, using both academic and non-academic channels, including films, briefs, webinars, training curriculum and materials.

B. Positions and Honors. Positions and Employment 1974 - 1977 Assistant Professor, Division of Allied Health Professions, School of Medicine, Emory University, Atlanta, GA 1982 - 1983 Assistant Professor, Department of Physical and Health Education, San Francisco State University, San Francisco, CA 1982 - 1987 Senior Research Associate, Institute for Health Policy Studies, University of California, San Francisco, San Francisco, CA 1992 - Assistant Adjunct Professor (1992-1998), Associate Adjunct Professor (1998-2000), Adjunct Professor (2000-2003), Professor, In Residence (2000-) Pediatrics and Health Policy, Department of Pediatrics, Division of Adolescent Medicine and Institute for Health Policy Studies, School of Medicine, University of California, San Francisco, San Francisco, CA 2003 - Joint Appointment, Department of Obstetrics, Gynecology, and Reproductive Health Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 2005 - Associate Director (2005-2009), Acting Director (2006-2007), Interim Director (2007-2009), Director (2009-) Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California, San Francisco, San Francisco, CA

Selected Honors 1991 Community Leadership Award, National Family Planning and Reproductive Health Association 1994 Integrity Award, Office of Inspector General, Office of Evaluation and Inspections, U.S. Department of Health and Human Services 1998 Society for Adolescent Medicine/Organon Visiting Professor in Adolescent Health 2000 Mark Pearlman Outstanding Service Award, California Child, Youth and Family Coalition 2000 California State Senate Resolution for distinguished service to the public and the State of California in conjunction with National Public Health Week 2000 Beverly A. Meyer Award for Excellence in Public Health, California Department of Health 2001 John C. MacQueen Lecture Award, Association of Maternal and Child Health Programs 2005 Maternal & Child Health Bureau Director’s Award: In Recognition of Contributions Made to the Health of Infants, Mothers, Children, Adolescents & Children with Special Needs 2006 California’s Family Planning Champion Award, California Family Health Council, Inc. For vision and commitment in creating and sustaining the California Office of Family Planning and the Family PACT Program. 2009 Chancellor’s Award for the Advancement of Women, UCSF 2011 - Member, Institute of Medicine of the National Academies (IOM) 2012 - UCLA School of Public Health Alumni Hall of Fame

C. Selected Peer-Reviewed Publications (selected from 145 peer-reviewed publications)

Most relevant to the current application 1. Guendelman S, Fernandez A, Thornton D, Brindis CD. Birthplace, Language Use, and Body Size Among Mexican American Women and Men: Findings from NHANES 2001-2006. Journal of the Poor and Underserved. Vol. 22, No. 2, 590– 605. 2011. 2. Brindis CD, Wolfe A, McCarter V, Ball S, Starbuck-Morales S. The association between immigrant status and risk-behavior patterns in Latino adolescents. Family Planning Perspectives 17:99-105, 1995. 3. Rodriguez M, Brindis CD. Violence and Latino youth: Prevention and methodological issues. Public Health Reports, 110(3):261-267.1995. 4. Canton G, Brindis CD. Prevalencia de Chlamydia en la mujer Embarazada (Prevalence of Chlamydia in Pregnant Women), Revista Centroamericana de Obstetricia y Ginecologìa (REVCOG) (Central American Journal of Obstetrics and Gynecology), 8(2):33-37.1998. 5. Chavez Alvarado S, Brindis CD, Yon C, Goldfarb N. Rural Andean Women’s Perspectives on Menopause. Hispanic Health Care International. 1(3): 142- 152.2002.

Additional recent publications of importance to the field (in chronological order)

6. Abbey N, Brindis CD, Casas M, Schoonmaker S. Family life education for Hispanics: Practical guidelines for schools. Family Life Educator, 6(1):4-10, Fall, 1987. 7. Brindis CD. Adolescent pregnancy prevention for Hispanic youth: The role of schools, families and communities. Journal of School Health, 62(7):345-351, 1992. 8. Garcia Baltazar J, Figueroa-Perea JG, Zapata HR, Brindis CD, Perez-Palacios G. Reproductive characteristics of adolescents and youths in the metropolitan area of Mexico City, 1987. Salud Pública de Mexico, 35(6):682-691.1993.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): 9. Chirinos JL, Brindis CD, Salazar VC, Bardales OT, Reategui LR. Perfil de las estudiantes adolescentes sexualmente activos en colegios secundarios de Lima, Peru (A profile of sexually active male adolescent high school students in Lima, Peru). Rev Med Hered, 10(1):49-61, 1999. 10. Castañeda X, Brindis CD, Castañeda I. Nebulous margins: Sexuality and social constructions of risks in rural areas of Central Mexico. Culture, Health, and Sexuality, 3(2): 203-219.2001. 11. Denner J, Kirby D, Coyle K, Brindis CD. The protective role of social capital and cultural norms in Latino communities: A study of adolescent births. Hispanic Journal of Behavioral Sciences, 23(1):3- 21.2001. 12. Clayson Z, Castaneda X, Sanchez E, Brindis CD. Unequal Power-Changing Landscapes: Negotiations Between Evaluation Stakeholders in Latino Communities. American Journal of Evaluation, 23(1): 33-44.2002. 13. Maternowska C, Estrada F, Campero L, Herrera C, Brindis CD, Votrejs MM, Brindis CD, Cuenca LC. Gender, Culture and Reproductive Decision Making Among Recent Mexican Migrants in California. Culture, Health, and Sexuality.1-15, iFirst. (http:// dx.doi.org/10.1080/13691050903108688).2009. 14. Schwartz S, Brindis CD, Ralph L, Biggs MA. Latina Adolescents’ Perceptions of their Male Partners’ Influences on Childbearing: Findings from a Qualitative Study in California. Culture, Health and Sexuality. Volume 13, (8) 873-886. 2011. 15. Minnis AM, Marchi K, Ralph L, Biggs A, Schwartz S, Arons A, Brindis CD, Braveman P. Limited socioeconomic opportunities and Latina teen childbearing: a qualitative study of family and structural factors affecting future expectations. Journal of Immigrant and Minority Health. Online. DOI 10.1007/s10903-012-9653-z. 2012.

D. Research Support

ACTIVE 10-95221 (Darney) 07/1/2010 - 06/30/2015 State of California, Office of Family Planning Evaluation of the Family PACT (Planning, Access, Care and Treatment) Program This evaluation of the states’ comprehensive family planning program includes billing data analyses, focus groups with providers and clients, exit interviews, cost-benefit analyses, and case studies.

10-10111 (Brindis) 12/1/2010 – 11/30/2013 California Department of Public Health Building Capacity to Advance the Health & Well-being of Adolescents To provide information, resources and expertise to support the provision of quality health care services to adolescents, increase the capacity of local Maternal, Child and Adolescent Health (MCAH) jurisdictions and their adolescent health practitioners to promote the health of adolescents, and to influence policy with the intent of improving the health and well-being of California’s adolescents.

10-95452 (Brindis) 07/01/2010 - 06/30/2015 California Department of Public Health Teen Pregnancy Prevention Project Evaluation California Department of Public Health, Office of Family Planning Evaluation research that help characterize the funded programs and estimate how well they are meeting the State’s objectives. Program evaluation results help public health professionals, educators, and policymakers to support more effective teenage pregnancy prevention interventions to reduce the negative social and economic consequences of this important public policy issue.

FPR PA006051 (Darney) 9/1/2009 - 8/31/2014 DHHS - Office Population Affairs Innovative evaluation of Title X and 1115 Waiver Family Planning Program Provide conceptual guidance to the development of project design and methodology and oversight of project planning and implementation. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

PENDING None.

OVERLAP None.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Tina Penick Brock Associate Dean for Global Health & Educational eRA COMMONS USER NAME (credential, e.g., agency login) Innovations; Professor of Clinical Pharmacy tmpbrock UCSF School of Pharmacy EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

University of Mississippi BA 05/90 German University of Mississippi BS 12/90 Pharmacy University of Mississippi MS 12/92 Pharmaceutical Sciences University of North Carolina at Chapel Hill EdD 12/04 Curriculum & Instruction

A. Personal Statement I am a pharmacist and educator with 20 years of experience in curriculum development in health professions educational programs around the world. My expertise is in health workforce assessment, curriculum development, technology-enhanced learning, interprofessional education and capacity building. I have successfully mentored numerous PharmD students, residents, fellows, and PhD students from idea generation through publication.

B. Positions and Honors

Positions and Employment: 1991 – 1991 Pharmacist, Student Health Center Pharmacy, Oxford, MS 1992 – 1992 Consultant, Partners in Pharmacy, McComb, MS 1992 – 1992 Assistant Manager, Medical Center Pharmacy, McComb, MS 1992 – 1995 Pharmacist, Psychiatry Service, Methodist Medical Center, Jackson, MS 1993 – 1995 Manager, Professional Development and Membership Services, Mississippi Pharmacists Association, Jackson, MS 1995 – 2001 Clinical Assistant Professor and Coordinator, Pharmaceutical Care Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 1998 – 1999 Clinical Pharmacist, UNC-Kerr Drug Enhanced Pharmaceutical Care Center, Chapel Hill, NC 1998 – 1999 Assistant Director, Student Services, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 1997 – 2005 Clinical Specialist, Pharmacy, Department of Pulmonary Medicine, University of North Carolina Hospitals Ambulatory Care Center, Chapel Hill, NC 1999 – 2005 Director, Student Services, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 2001 – 2006 Clinical Associate Professor, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 2005 – 2008 Lecturer and Director, MSc in Clinical Pharmacy - International Practice & Policy, School of Pharmacy, University of London, London, United Kingdom 2006 – 2011 Adjunct Assistant Professor, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 2008 - 2010 Director, Capacity Building & Performance Improvement, Center for Pharmaceutical Management, Management Sciences for Health, Arlington, VA 2008 - present Honorary Senior Lecturer in Practice & Policy, School of Pharmacy, University of London, London, United Kingdom

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page 2010 – present Professor of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA 2011 – present Associate Dean for Global Health & Educational Innovations, School of Pharmacy, University of California, San Francisco, San Francisco, CA

Honors and Awards 1990 Roche Pharmacy Communications Award 1990 AFPE/McNeil Graduate Fellowship Award 1993 Marion Merrell Dow Distinguished Young Pharmacist of Mississippi 1998 APhA – APPM Presentation Merit Award 2000 Paul G. Rogers/NCPIE Medication Communicator Award – Honorable Mention 2000 APhA – APPM Presentation Merit Award 2000 Albert B. Prescott/GlaxoSmithKline Leadership Award 2002 APhA – APPM Presentation Merit Award 2004 UNC Order of the Grail/Valkyries 2005 APhA-ASP National Outstanding Advisor Award 2006 Invited guest scientist, Ministry of Health, Welfare and Labor, Japan 2012 Elected President, Phi Lambda Sigma Leadership Honorary 2013 Outstanding Alumnus, University of Mississippi Department of Pharmacy Administration 2014 Fellow, American Pharmacists Association

C. Selected publications, posters & presentations (relevant to the current application):

Publications 1. Brock TP and Smith SR. An Interdisciplinary, Online Health Informatics Course. American Journal of Pharmaceutical Education. 2007, 71(3). Article 43. 2. Anderson C, Bates I, Beck D, Brock T, et al. FIP Pharmacy Education Taskforce – Enabling Concerted and Collective Global Action. American Journal of Pharmaceutical Education 2008, Vol: 72, Issue 06; Article: 127. 3. Anderson C, Bates I, Beck D, Brock T, et al. Scaling Up, Strengthening and Improving Pharmacy Education. Human Resources for Health 2009, 7:45. 4. Bruno A, Bates I, Brock T, Anderson C. Towards a global competency framework. American Journal of Pharmaceutical Education 2010, 74(3): Article 56. 5. Anderson C, Brock T, Bates I , Rouse M, Marriott J, Manasse H, Futter B, Bhojraj S, Brown A, and Gal D. Transforming health professional education. American Journal of Pharmaceutical Education 2011; 75(2): Article 22. 6. Anderson C, Bailey R, Bates I , Bhojraj S, Brock T, Brown A, Gal D, Futter B , Marriott J , Manasse H, and Rouse M. A Response to "Health professionals for a new century: transforming education to strengthen health systems in an interdependent world"(letter) The Lancet 2011; 377 (9773):1236-1237. 7. Anderson C, Bates I, Brock T. Seven billion humans and 98 trillion medicine doses. American Journal of Pharmaceutical Education 2012, 74(3): 75(10): Article 194. 8. Anderson C, Brown AN, Brock T, Rennie T, Bates I, Rouse M, Futter B, Bruno A. Needs-based education in the context of globalization. American Journal of Pharmaceutical Education 2012, 74 (4): Article 56. 9. Anderson C, Bates I, Brock T, Brown A, Bruno A, Gal D, Galbraith K, Marriott J, Rennie T, Rouse MJ, Tofade T. Highlights from the FIPEd global education report. Am J Pharm Educ. 2014 Feb 12;78(1):Article 4

Posters: 1. Bruno A, Bates I, Brock T. A global survey of pharmacy workforce competency frameworks. Annual Congress of the International Pharmaceutical Federation. Lisbon, Portugal. (September 2010) 2. Bruno A, Bates I, Brock T. Synthesising practitioner competencies in a global context. Annual Congress of the International Pharmaceutical Federation. Lisbon, Portugal. (September 2010) PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page 3. Sagwa E, Haoses-Gorases G, Mazibuko G, Mabirizi D, Nwokike J, Brock T, Lates J, Durango L, Bradley H, Duwiejua M, Woode E, Smit L, Stergachis A. Development of a needs- and competency- based pharmacy degree for Namibia. Annual Congress of the International Pharmaceutical Federation. Lisbon, Portugal. (September 2010) 4. Hitayezu F, Ntokamunda K, Ngangi P, Buki G, Morris M, Brock T. Strengthening the curriculum of the pharmacist degree course and harmonizing this with the comprehensive pharmacist profile for Rwanda. Annual Congress of the International Pharmaceutical Federation. Lisbon, Portugal. (September 2010) 5. Gal D, Chan XH, Bruno A, Anderson C, Brock T, Bates I, Rouse M, Bailey R. Assessing the status of pharmacy education globally: What information should regularly be collected and analysed at the global level. Annual Meeting of the European Association of Faculties of Pharmacy. Lisbon, Portugal (June 2011) 6. Rouse M, Brown A, Bruno A, Bates I, Brock TP. Developing consensus on foundation level competencies in a global competency framework. Lifelong Learning in Pharmacy Conference. Rotura, New Zealand. (June 2011) 7. Bruno A, Bates I, Brock T. Validating global competencies for hospital and community pharmacy. COIFFA Congress. European Association of Faculties of Pharmacy. Lisbon, Portugal (June 2011). 8. Brock TP, Bonnarens J, Hoffman J, Spies A, Euler M. A global dilemma for the pharmacy profession: leadership development. Annual Congress of the International Pharmaceutical Federation. Hyderabad, India. (September 2011) 9. Brock T, Cai J, Colley P, et al. Seeding strong roots for bountiful fruits: Interprofessionalism at the University of California, San Francisco. Annual Meeting of the American Association of Colleges of Pharmacy. Kissimmee, FL (July 2012) 10. Bouldin A, Brock TP, Bonnarens J. Transformational leadership in pharmacy: What is it and how do we develop it? Annual Congress of the International Pharmaceutical Federation. Amsterdam, The Netherlands (October 2012) 11. Bekes L, Brock T, Hamblett K, et al. Conceptualizing and implementing a new center for interprofessional education at the University of California, San Francisco. Collaborating Across Borders IV Conference. Vancouver, BC (June 2013) 12. Tran D, Beechinor R, Trester M, Brock TP. Interprofessional Learning Experience:A Pharmacy Student-Led Introductory Pharmacology Course for Physical Therapy Students. American Society of Health-System Pharmacists Midyear Clinical Meeting. Orlando, FL (December 2013) 13. Le P, Shoeb M, Glass M, Logar T, James-Ryan S, Brock T. An Experiential Learning Curriculum in Global Health Ethics Using Simulation. International Meeting on Simulation in Healthcare. San Francisco, CA (January 2014) 14. Anderson C, Bates I, Besançon L, Brock T, Brown AN, Bruno AF, Gal D, Galbraith K, Marriott J, Rennie T, Rouse M. Capability, Capacity and Scope – Developing and Applying the Tools Needed for Transformative Education, Optimising Access to and Use of Essential Medicines Worldwide. Prince Mahidol Award Conference –Transformative Learning for Health Equity. Bangkok, Thailand (January 2014) 15. Le P, Shoeb M, Glass M, Logar T, James-Ryan S, Brock T. Global Health Ethics Simulation. Unite For Sight 11th Annual Global Health & Innovation Conference. Yale University (April 2014)

Presentations: 1. Global pharmacy education taskforce update. 68th Annual Congress of the International Pharmaceutical Federation. Basel, Switzerland (September 2008) 2. When a lion eats your pharmacist: Implications for task-shifting on patient and provider safety in the developing world. Injury Risk Management Research Centre at the University of New South Wales. Sydney, Australia (January 2009) 3. Learning to teach: A Workshop for new pharmacy faculty in the developing world. 69th Annual Congress of the International Pharmaceutical Federation. Istanbul, Turkey (September 2009) 4. National pharmacovigilance systems: Ensuring the safe use of medicines through capacity building. USAID-sponsored conference held in Nairobi, Kenya (August 2010) 5. How to develop academic capacity to ensure seamless education. 70th Annual Congress of the International Pharmaceutical Federation. Lisbon, Portugal (September 2010) PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page 6. Global competencies for pharmacy education and the UNITWIN project. Global Health Workforce Alliance 2nd Forum on Human Resources for Health. Bangkok, Thailand (January 2011) 7. Careers and leadership in pharmacy and education. 71st Annual Congress of the International Pharmaceutical Federation. Hyderabad, India (September 2011) 8. Pedagogy driving the use of technology in global education. 71st Annual Congress of the International Pharmaceutical Federation. Hyderabad, India (September 2011) 9. The impact of clinical pharmacist roles in global health. American College of Clinical Pharmacy Annual Meeting. Pittsburgh, PA (October 2011) 10. Using student portfolios to enhance reflective learning in health professions education. Hawai’i International Conference on Education. Honolulu, HI (January 2012) 11. Performance-based learning… the Top Gear Approach. Monash Pharmacy Education Symposium. Prato, Italy (July 2013) 12. Using the virtual environment to link teaching and learning. Monash Pharmacy Education Symposium. Prato, Italy (July 2013)

D. Funded Research (relevant to the current application)

2002 – 2003 UNC Interdisciplinary Education Grant: $25,000. An interdisciplinary course in health informatics. (Principal investigator) 2003 – 2005 Merck Company Foundation: $30,000. An interdisciplinary distance education program in health informatics. (Principal investigator) 2007 – 2010 UK Department for International Development/DElPHE scheme: £16,500. Promoting appropriate use of medicines for poorer patients in Indonesia through pharmacy service development and evaluation. (Co-investigator) 2007 – 2010 NHS Connecting for Health Evaluation Programme: £745,608.24. Evaluation of the electronic prescription service in primary care. (Co-investigator) 2013 – 2015 UCSF Interprofessional Instructional Improvement Grant. Deepening patient-centered interviewing and counseling for behavior change skills. $16,000. Collaborator with JoAnne Saxe, RN, DNP. 2013 – 2015 UCSF Interprofessional Instructional Improvement Grant. An Interprofessional Experiential Learning Curriculum in Global Health Ethics Using Simulation. $15,260. Collaborator with Phuoc Le, MD, MPH

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Burke, Nancy J.

NAME POSITION TITLE Burke, Nancy J. Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) BurkeNA EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Tennessee, Knoxville, TN B.A. 1990 English Literature University of Oregon, Eugene, OR M.A. 1995 Cultural Anthropology University of New Mexico, Albuquerque, NM Ph.D. 2001 Ethnology

A. Personal Statement A medical anthropologist and health disparities researcher, I have taught the Social and Cultural Determinants of Health (Fall 2009) and Global Health Research Methods (Winter 2009-Fall 2014) courses in the Global Health Sciences Master’s Program at UCSF. I have served as academic mentor for 13 students and as primary capstone research mentor for three students. One of these has published his Capstone (Collins et al. 2013), another has a manuscript under review (Gabitova & Burke, Under Review), and the third in preparation (Napoles & Burke). I have an active research program in Havana, Cuba, focused on integrative oncology and chronic disease management. I recently published Health Travels: Cuban Health(care) on and off the Island (2013), the first critical analysis of Cuban healthcare from a global health perspective. In the Unites States, I am currently Principal Investigator of an NCI K07 Career Development Award that addresses organizational and interpersonal aspects of information disparities in cancer clinical trial recruitment (“Communicating about Clinical Trials: Bringing the CIS to the Underserved”), as well as several other projects addressing health literacy and social inequality in cancer care. As an example, I am currently working with a community based organization to develop and implement a peer support navigation program for Tagalog speakers to address systems navigation challenges, and recently completed a study of the use of community-based care navigators as sources of low literacy multi-lingual clinical trial information for underserved women. My research program, generally focused on social inequalities in cancer and chronic disease prevention and treatment, serves as a rich pedagogical resource for global health students.

B. Positions and Honors Positions and Employment 2000 - 2002 Research Scientist, Refugee and Immigrant Health Promotion Program, Harborview Medical Center, University of Washington 2001 Lecturer, University of Washington, Women’s Studies Department, Spring Quarter 2001 Visiting Professor, Pacific Lutheran University, Department of Anthropology, Fall Quarter 2001 - 2002 Qualitative Data Analyst (P/T), University of Washington and Fred Hutchinson Cancer Research Center 2002 Visiting Professor, University of Washington, Bothell, Interdisciplinary Arts and Sciences 2002 - 2004 Research Scientist, Comprehensive Cancer Center Population Sciences, University of California, San Francisco 2004 - 2010 Assistant Professor, Department of Anthropology, History, and Social Medicine/Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco 2010 - present Associate Professor, Department of Anthropology, History, and Social Medicine/Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Burke, Nancy J. Honors and Awards (last 10 years) 2003 Fellow, Cancer, Culture, and Literacy Institute, Moffitt Cancer Center and Research Institute, Tampa, Florida 2003 Latino Studies Research and Dissertation Award, Latin American Studies Association, Honorable Mention 2004-present National Institutes of Health, Health Disparities Loan Repayment Program 2005 Fellow, Advanced Training Institute on Health Behavior Theory, National Cancer Institute, Madison, Wisconsin 2008 Advanced Training in Scientific Leadership, Gladstone Institute, UCSF 2008 Medical Diplomacy Fellow, Institute for Global Health Sciences, UCSF 2012 Community Researcher Award, Zero Breast Cancer, Marin Co., CA 2014 Coro Faculty Leadership Collaborative, Chancellor's Council on Faculty Life, CORO Center f or Civic Leadership, UCSF

C1. Selected Peer-reviewed Publications Collins SP, Goldenberg SM, Burke NJ, Bojorquez-Chapela I, Silverman JG, & Strathdee SA. Situating HIV risk in the lives of formerly trafficked female sex workers on the Mexico–US border, 2012 AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV Gabitova G, Burke NJ. Improving Healthcare Empowerment through Breast Cancer Patient Navigation: A Mixed Methods Evaluation in a Safety-net Setting. BMC Health Services Research. Under Review. Burke NJ, Bird JA, Clark MA, Rakowski W, Guerra C, Barker JC, Pasick RJ. Social and cultural meanings of self-efficacy. Health Education and Behavior 2009; 36:111S-128S. PMCID: PMC2921833 Joseph G, Burke NJ, Tuason N, Barker JC, Pasick RJ. Perceived susceptibility to illness and perceived benefits of preventive care: An exploration of behavioral theory constructs in a transcultural context. Health Education and Behavior, 2009; 36:71S-90S. PMCID: PMC2941192 Gao G, Burke NJ, Somkin CP, Pasick R. Considering culture in physician-patient communication during colorectal cancer screening. Qualitative Health Research 2009; 19:778-789. PMCID: PMC2921881 Burke NJ, Barker JC. Health Communication “Noise”: Insights from Medical Anthropology. Hamilton H and Chou WY, Eds. Routledge Handbook of Language and Health Communication. Oxfordshire: Routledge, Taylor & Francis Group. January 2014. Burke NJ, Jackson JC, Thai HC, Stackhouse F, Nguyen T, Chen A, Taylor VM. Honoring Tradition, Accepting New Ways: Development of a hepatitis B control intervention for Vietnamese immigrants. Ethnicity and Health 2004; 9:153-169. PMID: 15223574 Burke NJ, Jackson JC, Thai HC, Lam DH, Chan N, Acorda E, Taylor VM. Good Health for New Years: Development of a cervical cancer control outreach program for Vietnamese immigrants. Journal of Cancer Education 2004; 19:244-250. PMID: 15725644 Taylor VM, Yasui Y, Burke NJ, Nguyen T, Acorda E, Thai H, Qu P, Jackson JC. Pap testing adherence among Vietnamese American women. Cancer, Epidemiology, Biomarkers and Prevention 2004; 13:613-619. PMID: 15066927 Taylor VM, Yasui Y, Burke NJ, Nguyen T, Chen A, Acorda E, Choe JH, Jackson JC. Hepatitis B testing among Vietnamese American men. Cancer Detection and Prevention 2004; 28:170-177. PMID: 15225896 Taylor VM, Yasui Y, Burke NJ, Choe JH, Acorda E, Jackson JC. Hepatitis B knowledge and testing among Vietnamese-American women. Ethnicity and Disease 2005; 15:761-767. PMID: 16259505 Taylor VM, Choe JH, Yasui Y, Li L, Burke NJ, Jackson JC. Hepatitis B awareness, testing and knowledge among Vietnamese American men and women. Journal of Community Health 2005; 30:477-490. PMCID: PMC1810895 Choe JH, Tu SP, Lim JM, Burke NJ, Acorda E, Taylor VM. Heat in their intestine: Colorectal cancer prevention beliefs among older Chinese Americans. Ethnicity and Disease 2006; 16:248-254. PMID: 16599379

PHS 398/2590 (Rev. 06/09) Page 2 Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Burke, Nancy J. Choe JH, Taylor VM, Yasui Y, Burke NJ, Nguyen T, Acorda E, Jackson JC. Health care access and sociodemographic factors associated with hepatitis B testing in Vietnamese American men. Journal of Immigrant and Minority Health 2006; 8:193-201. PMID: 16791529 Do HH, Taylor VM, Burke NJ, Yasui Y, Schwartz SM, Jackson JC. Knowledge about cervical cancer risk factors, traditional health beliefs, and Pap testing among Vietnamese American women. Journal of Immigrant and Minority Health. 2007; 9:109-114. PMID: 17165138 Pasick RJ, Burke NJ. A critical review of theory in breast cancer screening promotion across cultures. Annual Review of Public Health 2008; 29:351-368. PMID: 17914932 Burke NJ, Joseph G, Pasick RJ, Barker JC. Theorizing social context: Rethinking behavioral theory. Health Education and Behavior 2009; 36:55S-70S. PMID: 19805791 Pasick RJ, Burke NJ, et al. Behavioral theory in a diverse society: Like a compass on Mars. Health Education and Behavior 2009; 36:11S-35S. PMCID: PMC2921832 Burke NJ, Do HH, Talbot J, Sos C, Svy D, Taylor VM. Chunmguh Thleum: Understanding liver illness and hepatitis B among Cambodian immigrants. Journal of Community Health 2011; 36:27-34. PMCID: PMC3020312 Burke NJ, Villero O, Guerra C. Passing through: Meanings of survivorship and support among Filipinas with breast cancer. Qualitative Health Research 2011 Aug 29. [Epub ahead of print] PMID: 2187620

D. Research Support Ongoing Research Support Mt. Zion Health Fund (Burke NJ) 1/1/2014 – 12/31/2014 Developing a Low-literacy, Multi-lingual Breast Cancer Survivorship Care Plan This study, conducted in partnership with the San Francisco Women’s Cancer Network, is designed to identify informational and navigational needs for medically underserved breast cancer patients at key care transition points, specifically at the five-year mark. These data will be used to develop and pretest multi-lingual (English, Spanish, Tagalog, Chinese, Russian) survivorship care plan materials. Role: Principal Investigator: 10% effort.

22RT-0089 Tobacco Related Disease Research Program (Tsoh) 8/1/2013 - 7/31/2016 A Family Intervention to Reduce Smoking in Vietnamese Men This study will test the 6-month efficacy of a family-based intervention utilizing lay health worker outreach and family involvement to promote smoking cessation in Vietnamese male smokers. A randomized controlled trial targeting 18 lay health workers and 108 smoker-family dyads will be conducted. Role: Co-Investigator, 4.8% effort.

NIH/NCI K07 CA126999 (Burke NJ) 7/1/2008 – 6/30/2014 Communicating about Clinical Trials: Bringing the CIS to the Underserved The purpose of this study is to bring appropriate and accurate clinical trials information to African American, Latino and White public hospital cancer patients in order to support their decision making about clinical trails participation. The specific aims are to gain a deep understanding of clinical trial information needs and resources of these patients, how to incorporate the Cancer Information Service (CIS) into their information seeking strategies, and how to adapt current CIS services to better address the clinical trial information needs of these callers. Role: Principal Investigator, 16% effort.

Avon Foundation Breast Cancer Disparities (Luce J) 7/1/2013 – 6/30/2014 A Collaborative Project to Develop Survivorship Materials for Underserved Women with Breast Cancer The 2012 American College of Surgeons Commission on Cancer “Cancer Program Standards: Ensuring Patient Centered Care” requires the development and implementation of care transition plans for all cancer survivors as a standard of care. This project employs inductive qualitative methods with breast cancer survivors and providers to develop low literacy multilingual survivorship care transition materials for use in safety net hospitals. Role: Pilot PI, 10% effort.

Academic Senate, UCSF (Burke, NJ) 8/1/13-7/30/14 Oral Health Literacy (OHL) for English as a Second Language (ESL) Learners. This pilot study employs PHS 398/2590 (Rev. 06/09) Page 3 Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Burke, Nancy J. inductive qualitative methods to identify and define navigational aspects of OHL for Mexican immigrant parents of young children. 10% effort.

NIH / National Institute on Drug Abuse R21 DA030569 (Tsoh) 3/1/2011 – 2/28/2014 A Family Intervention to Reduce Smoking among Chinese and Vietnamese Men. This study examines the feasibility of an intervention using lay health worker outreach to involve both smokers and their family members in the Chinese and Vietnamese populations. Role: Co-Investigator. 5% effort.

Completed Research Support (in the Last 3 Years) Mt. Zion Health Fund (Burke, NJ) 1/1/13-12/20/13 Buong Puso: Linking Filipinas with Breast Cancer to Care and Support Resources. The goal of this collaboration between the Pilipino Senior Resource Center, the Mt. Zion Department of Radiology, and the Department of Anthropology, History and Social Medicine is to assess the feasibility and acceptability of a peer support program for Filipinas undergoing treatment for breast cancer.

TRDRP 19XT-0083 (Tsoh) 7/1/2010 – 6/30/2013 A Family Intervention to Reduce Smoking in Vietnamese Men This study uses mixed research methods to develop a family intervention using lay health worker outreach to promote smoking cessation in Vietnamese American men. Role: Co-Investigator

Avon Foundation Breast Cancer Disparities (Luce J) 7/1/2012 – 6/30/2013 “Big Sister”: A Model of Filipina Breast Cancer Support Building upon findings from a previous five year study of breast cancer support resources in the Filipina community in San Francisco, this pilot explores the feasibility of the implementation of a one-on-one patient navigation program in a community-based organization serving Filipina breast cancer survivors. Role: Pilot Principal Investigator.

17AB-1500 CA Breast Cancer Rsch Prog (Joseph & Caprio) 7/1/2011 – 03/31/2013 Clinical Trials Education and Access for Underserved Women This study brings together the Shanti Breast Cancer Program, UCSF faculty, and BreastCancerTrials.org (BCT.org), a non-profit clinical trials matching service. The overall goal is to assess the potential role of a trusted CBO as a source of culturally appropriate education and access to clinical trials. This pilot study designed a Clinical Trials education program for Shanti Care Navigators to deliver to clients and a protocol for navigator-facilitated access to BCT.org. Role: Co-I.

NIH/NCI K07 CA126999-02S1 (Burke NJ) 10/1/2009-6/30/2011 American Recovery and Reinvestment Act Supplement to the KO7 Career Development Award This ethnographic ARRA Supplement conducted follow-ups with “interested but unsure” public hospital patients who had been offered CCT participation (African American, European-American, and Latino) out of the clinic into the wider contexts of CCT decision-making (home, work, community, family). Role: Principal Investigator.

DISP0706939 (Burke, PI) 11/01/2007-10/31/2011 Susan G. Komen Foundation Breast Cancer Disparities Filipina Breast Cancer Support: What Model is Meaningful? The purpose of this study is to conduct ethnographic research into social support and social capital within the Filipino community as the basis for the development of culturally appropriate and sustainable breast cancer support services. Role: Principal Investigator

Gump Cancer Fd/Hampton Med Res (Burke, PI) 01/01/2010 – 12/31/2011 REAC Pilot, University of California, San Francisco Contexts of Cancer Clinical Trial Decision-making among Chinese Patients. The purpose of this ethnographic study is the in-depth exploration of the clinical trial decision-making process with Chinese public hospital patients. The outcome of this pilot is not increased recruitment to cancer clinical trials, but rather in-depth understanding of the contexts in which cancer clinical trial decision-making occurs for Chinese public hospital patients. Role: Principal Investigator

PHS 398/2590 (Rev. 06/09) Page 4 Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Coates, Thomas J. Professor of Medicine and Epidemiology eRA COMMONS USER NAME TCOATS EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) San Luis Rey College, California B.A. 06/68 Philosophy San Jose State University, California M.A. 06/71 Psychology Stanford University, California Ph.D. 06/77 Counseling Psychology

A. Personal Statement I am the Director of the UCLA Division of Infectious Diseases, Global Health program (since 2003) and the Director of the UCLA Center for World Health (founded in 2012). I am the Michael and Sue Steinberg Endowed Professor of Global AIDS Research within the Division of Infectious Diseases at UCLA. In 1986 I co-founded the Center for AIDS Prevention Studies (CAPS) at UCSF and directed it from 1991 to 2003. I was also the founding Executive Director of the UCSF AIDS Research Institute, leading it from 1996 to 2003. My areas of emphasis and expertise are HIV prevention, the relationship of prevention and treatment for HIV, and HIV policies.

B. Positions and Honors 1984 - 2003 Member, Medical Attending Staff, UCSF Hospitals and Clinics 1990 - 2003 Professor, Department of Medicine, UCSF 1991 - 2003 Director, Center for AIDS Prevention Studies, UCSF 1996 - 2003 Director, AIDS Research Institute, UCSF 2003 - 2006 Professor Step VII, Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA 2003 - Present Joint Appointment, Department of Medicine, UCSF; Member, Executive Committee, UCLA AIDS Institute 2003 - Present Director, UCLA Program in Global Health 2004 - Present Joint Appointment, Department of Epidemiology, UCLA School of Public Health 2006 - Present Professor Step IX, Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA 2006 - Present Michael & Sue Steinberg Endowed Professor of Global AIDS Research, Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA 2009 - Present Co-director, University of California Global Health Institute 2010 - Present Co-director, UCLA Global Health Education Program

C. Selected Peer-reviewed Publications (Publications selected from 283 peer-reviewed publications)

1. Sweat M, Morin S, Celentano D, Mulawa M, Singh B, Mbwambo J, Kawichai S, Chingono A, Khumalo- Sakutukwa G, Gray G, Richter L, Kulich M, Sadowski A, Coates TJ; the Project Accept study team. Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study. Lancet Infect Dis. 2011 Jul;11(7):525-32. Epub 2011 May 3. PMC3156626 2. Mindry D, Maman S, Chirowodza A, Muravha T, van Rooyen H, Coates TJ. Looking into the Future; South Africa men and women negotiating HIV risk and relationship intimacy (Project Accept/HPTN 043). Cult Health Sex. 2011 May;13(5):589-602. PMC3071520

3. Roland ME, Myer L, Martin LJ, Maw A, Batra P, Arend E, Coates TJ, Denny LA. Preventing Human Immunodeficiency Virus Infection Among Sexual Assault Survivors in Cape Town, South Africa: An Observational Study. AIDS Behav. 2011 Feb 8. PMC3071520

4. Venkatesh KK, Madiba P, De Bruyn G, Lurie MN, Coates TJ, Gray GE. Who gets tested for HIV in a South African urban township? Implications for test and treat and gender-based prevention interventions. J Acquir Immune Defic Syndr. 2011 Feb 1;56(2):151-65. PMC3137901

5. Truong HH, Fritz K, McFarland W, Hartogensis W, Fiamma A, Coates TJ, Morin SF. Recent HIV Type 1 Infection Among Participants in a Same-Day Mobile Testing Pilot Study in Zimbabwe. AIDS Res Hum Retroviruses. 2011 Jun;27(6):593-5. Epub 2011. PMC3101086

6. Konda KA, Celentano DD, Kegeles S, Coates TJ, Caceres CF; NIMH Collaborative HIV/STD Prevention Trial Group. Latent Class Analysis of Sexual Risk Patterns Among Esquineros (Street Corner Men) a Group of Heterosexually Identified, Socially Marginalized Men in Urban Coastal Peru. AIDS Behav. 2011 May; 15(4):862-8. PMC3005540

7. Clark JL, Segura ER, Montano SM, Leon SR, Kochel T, Salvatierra HJ, Alcantara J, Caceres CF, Coates TJ, Klausner JD. Routine Laboratory Screening for Acute and Recent HIV Infection in Lima, Peru. STI. 2010 Dec;86(7):545-7. PMC3050669

9. Young SD, Hlavka Z, Modiba P, Gray G, Van Rooyen H, Richter L, Szekeres G, Coates TJ. HIV-Related Stigma, Social Norms, and HIV Testing in Soweto and Vulindela, South Africa: National Institutes of Mental Health Project Accept (HPTN 043). J Acquir Immune Defic Syndr. 2010 Oct 27;55:62-624. PMC3136617

10. NIMH Collaborative HIV/STD Prevention Trial Group. Results of the NIMH Collaborative HIV/Sexually Transmitted Disease Prevention Trial of a Community Popular Opinion Leader Intervention. J Acquir Immune Defic Syndr. 2010 Jun;54(2):204-14. PMC2904551

11. Snowden JM, Konda KA, Leon SR, Giron JM, Escobar G, Coates TJ, Caceres CF, Klausner JD; the NIMH HIV/STD Collaborative Intervention Trial. Recent Syphilis Infection Prevalence and Risk Factors Among Male Low-Income Populations in Coastal Peruvian Cities. Sex Transm Dis. 2010 Feb; 37(2):75-80. PMC2873856

12. Clark JL, Konda KA, Segura ER, Salvatierra HJ, Leon SR, Hall ER, Caceres CF, Klausner JD, Coates TJ. Risk Factors for the Spread of HIV and Other Sexually Transmitted Infections Among HIV-infected Men Who Have Sex with Men in Lima, Peru. STI (Special issue on MSM) 2009; 84 (6): 449-54; PMC19028945

13. Clark JL, Lescano AG, Konda KA, Leon SR, Jones FR, Klausner JD, Coates TJ, Caceres CF; NIMH International Collaborative HIV/STD Prevention Trial. Syndromic Management and STI Control in Urban Peru. PLoS One. 2009 Sep 25;4(9):e7201. PMC2745701

14. Leon SR, Konda KA, Bernstein KT, Pajuelo JB, Rosasco AM, Caceres CF, Coates TJ, Klausner JD. Trichomonas vaginalis Infection and Associated Risk factors in a Socially-marginalized Female Population in Coastal Peru. Infect Dis Obstet Gynecol. 2009;2009:752437. Epub 2009 Jun 29. PMC2704012

15. Khumalo-Sakutukwa G, Morin SF, Fritz K, Charlebois ED, van Rooyen H, Chingono A, Modiba P, Mrumbi K, Visrutaratna S, Singh B, Sweat M, Celentano DD, Coates TJ; NIMH Project Accept Study Team. Project Accept (HPTN 043): A Community-based Intervention to Reduce HIV Incidence in Populations At Risk for HIV in sub-Saharan Africa and Thailand. J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):422-31. PMC 2664736

D. Research Support

Ongoing Research Support

P30 MH58107 (Rotheram-Borus) 02/01/07 - 01/31/17 NIH/NIMH Center for HIV Identification, Prevention, and Treatment Services (CHIPTS) The mission of the Center for HIV Identification, Prevention, and Treatment Services (CHIPTS) is to promote collaborative research and education on effective HIV detection, prevention, and treatment programs for HIV at the societal, community, provider, and individual levels. My role is as the Director for International Care.

USDS Agency for Internal Development (USAID) 03/15/10 - 03/14/15 Building Capacity for HIV Prevention, Treatment, and Care in Malawi A collaborative project to rapidly enhance the continuum of care, improve health care training and services, and increase data quality and information dissemination for decision making in Malawi. My role is as the Principal Investigator.

U01 AI068619 (Vermund) 07/01/06 – 11/30/14 Family Health International Funded under NIH 1 HIV Prevention Trials Network (HPTN) Leadership Group The goals of this project are: 1) to develop the HPTN research agenda; 2) to review SWG research plans; 3) to review and approve concept plans; 4) to oversee the discretionary fund; 5) to review and revise HPTN policies and procedures; and 6) to evaluate the performance of the HPTN. My role is as a Executive Committee Member.

P30 AI28697 (Chen) 01/01/08 - 12/31/14 NIH/NIAID UCLA Center for AIDS Research (CFAR) Support for shared core services for AIDS-related research by UCLA investigators. This center grant does not provide independent research support. My role is as the Associate Director.

Completed Research Support

R01 MH077512-01 (Coates) 09/13/07 - 07/31/13 NIH/NIMH HIV VCT and Linkage to Care in Uganda Specific aims of the study are to test the hypotheses (1) that routine counseling and testing HIV among is as efficacious as traditional counseling and testing in reducing HIV risk behavior and (2) that an “enhanced linkage to care” model of referral to HIV-specific medical care is more effective than usual referrals. My role is as the Principal Investigator.

U01 MH66701 (Coates) 09/30/03 - 06/30/13 NIH/NIMH Community-Based HIV VCT: South Africa The goal of this study is to conduct a CBCVT intervention in South African communities with the goal of changing community norms and reducing risk for HIV infection among it members. My role is as the Principal Investigator.

RO1AI083034 (Celum) 04/17/09 - 03/31/13 University of Washington/NIH/NIAID Multicomponent, Targeted HIV Prevention for Sub-Saharan Africa: PreventionRX

The goal of this study is to develop a coordinated, multi-component HIV prevention package of evidence-based biomedical and behavioral interventions that will be individually-tailored and targeted to maximize coverage and impact on HIV incidence in an African population. My role is as the Co-Principal Investigator.

R01 MH075639 (Coates) 09/09/05 - 08/31/12 NIH/NIMH Integrating HIV/STI Prevention/Treatment in China The goal of the project is to teach physicians in rural China how to enhance and integrate prevention and care for HIV and STIs. Public health impact: This project has the potential to provide a replicable and widespread training program to teach physicians to integrate HIV and STI prevention and care. My role is as the Principal Investigator.

R01 MH078752 (Coates) 09/28/06 - 07/31/12 NIH/NIMH Comunidades Positivas and Enhanced Partner Therapy in Peru This project will implement novel strategies for HIV and STI prevention among HIV/STI prevention strategies among men who have sex with men in low income barrios in Peru. My role is as the Principal Investigator.

Ford Foundation (Coates) 05/01/06 - 12/31/11 UCLA Activities Related to the Ford Foundation Global HIV/AIDS Policy Initiative: 2006 – 2010 This grant supports consultative activities between UCLA and the Ford Foundation to assist the Ford Foundation in establishing its HIV/AIDS Global Initiative. My role is as the Principal investigator. My role is as the Principal Investigator.

BIOGRAPHICAL SKETCH NAME POSITION TITLE Cohen, Craig R. Professor In-Residence Honorary Lecturer eRA COMMONS USER NAME: CRCOHEN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, andINSTITUTION include po stdoctoralAND LOCATION training.) DEGREE YEAR(s) FIELD OF STUDY University of California, Los Angeles, CA None 1980-2 Science University of California, Berkeley, CA BA 1982-4 Molecular Biology University of Louisville School of Medicine, KY MD 1986-90 Medicine University of Washington School of PH, WA MPH 1997 Epidemiology A. Personal Statement I lived and worked in Nairobi between 1994 and 2002, working with researchers from both KEMRI and the University of Nairobi. Since its inception in 2004, I have been the PI/Director of the CDC/PEPFAR-funded Kenya-based Family AIDS Care and Education Services (FACES) HIV care and support program with supports care, treatment and prevention of HIV to over 130,000 people in western Kenya. FACES serves as the foundation for approximately 20 clinical and implementation research studies, including the SEARCH trial, which is a community-based cluster randomized controlled trial to determine if annual HIV testing and immediate provision of antiretroviral therapy reduces the incidence of HIV. I am the Co-PI of SEARCH in Kenya. In addition, I have led multiple clinical investigations in reproductive infectious diseases, including LACTIN-V to prevent recurrent bacterial vaginosis, and 3% SPL7013 (VivaGel), and the recently completed cluster randomized controlled trials on the integration of reproductive health and HIV services. I am PI/Director of the NIH supported Reproductive Infectious Disease Fellowship program in the Department of Obstetrics, Gynecology and Reproductive Sciences at UCSF, and the Co-PI/Co-Director of the NIH Fogarty International Center-supported GloCal Health Fellowship which support training of post-doctoral fellows and doctoral students at 14 countries around the world including Kenya.

B. Positions and Honors Positions: 1997-Present Visiting Lecturer, Department of Obstetrics & Gynecology, University of Nairobi, Kenya. 1997-Present Visiting Senior Scientist, Center for Respiratory Disease Research, Kenya Medical Research Institute 2004-Present Fellowship Director, Reproductive Infectious Disease Fellowship, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco 2009-Present Professor in-Residence, Department of Obstetrics & Gynecology, UCSF 2010-Present Co-Director, UC Global Health Institute Center of Expertise in Women’s Health & Empowerment

Honors: 2012 UCSF School of Medicine Mentor of the Year of students in research 2010 UCSF AIDS Research Institute 2010 Award for Outstanding Mentor, nomination 1989 Alpha Omega Alpha Honors Society 1989 Who's Who of American College Students 1987 Dr. Calhoon Prize in Physiology 1987 Linker Community Service Award 1981 Dean’s list at UCLA

C. Selected peer-reviewed publications in chronological order (from 101 published articles) 1. Karari C, Tittle R, Penner J, Kulzer J, Bukusi EA, Marima R, Cohen CR. Evaluating the Uptake, Acceptability, and Effectiveness of Uliza! Clinicians' HIV Hotline: A Telephone Consultation Service in Kenya. Telemed J E Health. 2011 Jul-Aug;17(6):420-6. Epub 2011 May 25. PMID: 21612519. 2. Craig R. Cohen, Joelle Brown, Anna-Barbara Moscicki, Elizabeth A Bukusi, Jeremy R.A. Paull, Clare F. Price, Stephen Shiboski. A phase I randomized placebo controlled trial of the safety of 3% SPL7013 Gel (VivaGel®) in healthy young women administered twice daily for 14 days. PLoS One, 2011, 20;6(1):e16258. PMID: 21311578. 3. Craig R Cohen, Anna-Barbara Moscicki, Mark E Scott, Yifei Ma, Stephen Shiboski, Elizabeth Bukusi, Ibrahim Daud, Anu Rebbapragada, Joelle Brown, Rupert Kaul. Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa. AIDS, 2010;24:2069–2074. PMID: 20588163. 4. SG Brubaker, EA Bukusi, J Odoyo, J Achando, A Okumu and CR Cohen. Pregnancy and HIV transmission among HIV-discordant couples in a clinical trial in Kisumu, Kenya. HIV Medicine 2010;10:j.1468-1293. PMID: 21205129. 5. Craig R. Cohen, Michele Montandon, Adam W. Carrico, Stephen Shiboski, Alan Bostrom, Alfredo Obure, Zachary Kwena, Robert C. Bailey, Rosemary Nguti, Elizabeth A. Bukusi. Association of attitudes and beliefs towards antiretroviral therapy with HIV-seroprevalence in the general population of Kisumu, Kenya. PLoS One. 2009;4(3):e4573. Epub 2009 Mar 4. PMID: 19259267. 6. Michele Montandon, Nuriye Nalan Sahin-Hodoglugil, Elizabeth Bukusi, Kawango Agot, Brigid Boland, Craig R Cohen. Sexuality, HIV Risk and Potential Acceptability of Involving Adolescent Girls in Microbicide Research in Kisumu, Kenya. Sexual Health 2008 Dec;5(4):339-46. PMID: 19061553. 7. Videlis N Nduba, Christina W Mwachari, Amalia S Magaret, David R Park, Andrew Kigo, Thomas M. Hooton, Craig R Cohen. Placebo found Equivalent to Amoxicillin for Treatment of Acute Bronchitis in Nairobi, Kenya: A Triple-Blind Randomized Equivalence Trial. Thorax. 2008 Nov;63(11):999-1005. Epub 2008 Jun 17. PMID: 18559367. 8. Janet Turan, Elizabeth A Bukusi, John Sande, Craig R Cohen. HIV/AIDS and maternity care in Kenya: How fears of stigma and discrimination affect uptake and provision of labor and delivery services. AIDS Care 2008 Sep;20(8):938-45. PMID: 18777222. 9. Michael Bolton, Ariane van der Straten, Craig R. Cohen. Probiotics: Potential to Prevent HIV and Sexually Transmitted Infections in Women. Sex Transm Dis, 2008;35:214-225. PMID: 18490864. 10. Christina Mwachari, Videlis Nduba, Rosemary Nguti, David R Park, Lucy Sanguli, Craig R Cohen. Validation of a new clinical scoring system for acute bronchitis. Int J Tuberc Lung Dis 2007 Nov; 11(11):1253-9. PMID: 17958990. 11. Jenell S. Coleman MD, Jane Hitti, Elizabeth A Bukusi, Christina Mwachari, Angela Muliro, Rosemary Nguti, Reggie Gausman, Sarah Jensen, Dorothy Patton, David Lockhart, Robert Coombs, Craig R Cohen. Infectious correlates of HIV-1 shedding in the female upper and lower genital tracts. AIDS 2007;21:755-9. PMID: 17413697. 12. Anjali Sharma, Elizabeth Bukusi, Samuel Posner, Douglas Feldman, Elizabeth Ngugi, Craig R Cohen. Sex preparation and diaphragm acceptability in sex work in Nairobi, Kenya. Sex Health 2006;3:261-8. PMID: 17112438. 13. Cohen CR, Nosek M, Meier A, Astete SG, Iverson-Cabral S, Mugo NR, Totten PA. Mycoplasma genitalium Infection and Persistence in a Cohort of Female Sex Workers in Nairobi, Kenya. Sex Transm Dis. 2006 Aug 28; [Epub ahead of print] PMID: 16940898. 14. Cohen CR, Manhart LE, Bukusi EA, Astete S, Brunham RC, Holmes KK, Sinei SK, Bwayo JJ, Totten PA. Association between Mycoplasma genitalium and acute endometritis. Lancet 2002;359:765-6. PMID: 11888591. 15. Craig R Cohen, Ann Duerr, Niwat Pruithithada, Sungwal Rugpao, Sharon Hillier, Patricia Garcia and Kenrad Nelson. Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand. AIDS 1995; 9:1093-1098. PMID 8527084.

D. Research Support Ongoing Research Support 1R25TW009343-01 (PI: Cohen) 4/04/12 – 2/28/17 NIH – Fogarty University of California Global Health Institute Program for Fellows and Scholars: This project will train pre-doctoral scholars and post-doctoral fellows from UC San Francisco, UC San Diego, UC Los Angeles, UC Davis and 21international collaborating institutions from low- and middle-income countries in a wide range of pressing and emerging global health issues. This program will be highly relevant as it will engage trainees in an intensive11-month project conducted at an international site. The program will produce multidisciplinary global health leaders and strengthen the network of research and training across UC campuses and its international partnering institutions. Program Director/Principal Investigator (Last, First, Middle): Cohen, Craig R.

1R34MH094215 (PI: Cohen) 8/15/11 – 5/31/15 NIMH Pilot agricultural intervention for food security and HIV health outcomes in Kenya: This project will support formative work and an expanded phase 1 trial of a multisectoral agricultural intervention to improve the health of HIV-infected persons in Kenya. This work will lead to the development of a R01/U01 grant to support a cluster randomized controlled trial of the intervention.

UM1 AI069502 SEARCH Supplement (PI: Havlir) 08/01/12 – 6/30/15 NIH/NIAID Adult AIDS Clinical Trials Unit (ACTG): This study will evaluate health, economic, education outcomes of CD4 independent ART in rural East Africa. The study intervention is designed to improve the continuum of care, reduce structural barriers for all populations and add on to evidence based interventions such as adult male circumcision.

U01AI0699-11 (PI: Wools-Kaloustian,Yiannoutsos) 8/1/13-7/31/15 NIH/NIAID East Africa IeDEA Consortium: This project aims to enhance understanding about the HIV-epidemic in its sub- Saharan Africa context, provide insights on the optimal structure and impact of care and treatment programs, expand the set of tools available to inform implementation and operations research in resource- constrained settings and inform policy among stakeholders and decision makers at every level in the region as well as the broader HIV/AIDS scientific community.

PS001913-01 (PI: Cohen) 7/1/10 - 6/30/15 Centers for Disease Control (CDC) Supporting the Implementation and Expansion of High Quality HIV Prevention, Care and Treatment Activities at Facility and Community Level in Kenya (Family AIDS Care and Education Services): This project expands comprehensive, integrated HIV services and strengthens the local healthcare systems to reduce HIV incidence, morbidity, and mortality in Nyanza and Nairobi Provinces, Kenya. The primary objectives are to expand primary prevention efforts; strengthen comprehensive HIV prevention, care, and treatment service delivery; and build local Government of Kenya HIV service and system capacity.

PHS 398/2590 (Rev. 06/09) Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Molly Cooke, MD Professor of Medicine eRA COMMONS USER NAME (credential, e.g., agency login) University of California, San Francisco (UCSF) Attending Physician, UCSF Medical Center EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Stanford University, Stanford, California BS 06/73 Biology Stanford University School of Medicine, Stanford MD 06/77 Medicine University of California, San Francisco 06/78 Medicine - Internship University of California, San Francisco 06/80 Medicine - Residency University of California, San Francisco 06/81 Medicine – Chief Residency University of California, San Francisco 06-83 Fellowship - Ethics

Please refer to the application instructions in order to complete sections A, B, C, and D of the Biographical Sketch.

A. Personal statement My career has focused on health professions education and program development. I have a particular interest in the intersection of health professions education, medical education research and health services research. I have a broad and deep theoretical foundation and extensive practical experience in health professions education and take as my theoretical orientation the ‘learning sciences’ generally, and sociocultural learning theory in particular. Topically, my work has addressed the challenge of efficient and effective preparation of health professionals to meet the health care needs in resource-poor parts of the world (14) and the emerging field of global health education. I have explored concepts such as patient-centered care (13) quality and safety (12), the role of foundational science in the formal training and continuing education of physicians, and how issues of cost and value should be addressed (10). Beginning in 2000 I built UCSF’s Academy of Medical Educators (4), a national mode for enhancing the value and prestige of teaching. While the title of my book, Educating Physicians: A Call for Reform of Medical School and Residency (2010) (15) emphasizes the preparation of medical doctors, my experience extends to transprofessional practice and health professions education more broadly. I have worked in health professions education in Guatemala, Uganda, and Zimbabwe, as well as in the developed world. A founding faculty member of the internal medicine residency at San Francisco General Hospital – UCSF, I developed GME curricula focused on the care of the urban under-served, including community health and advocacy. I serve as the School of Medicine’s liaison to UCSF’s regional campus in Fresno and, in that capacity and as a member of the San Joaquin Valley PRIME advisory board, address health inequities in California’s Central Valley. I provided the educational expertise for IDCAP, Infectious Disease Capacity Building Evaluation, a three-year project exploring cost- effective ways to build capacity among mid-level providers in sub-Saharan Africa funded by the Bill and Melinda Gates Foundation. I serve on the Training Advisory Committee of the University of Zimbabwe Medical Education Partnership Initiative (MEPI); the US partner institutions are the University of Colorado and Stanford University

B. Positions and Honors

Principal Positions Held: 1983 - 1988 Assistant Clinical Professor of Medicine, UCSF 1988 – 1989 Assistant Professor of Medicine, UCSF 1989 – 1994 Associate Professor of Medicine, UCSF 1994 – present Professor of Medicine, UCSF PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 1999 – 2002 Co-director, Center for Collaborative Primary Care, UCSF 2004 – 2009 Senior Scholar, Carnegie Foundation for the Advancement of Teaching 2012 – present Director of Education, UCSF Global Health Sciences

Honors and Awards: 1978 Diplomate, National Board of Medical Examiners 1981 Diplomate, American Board of Internal Medicine 2006 AOA Robert J. Glaser Distinguished Teacher Award, Association of American Medical C olleges 2010 Career Achievement Award in Education, Society for General Internal Medicine 2011 PROSE award for distinction in scholarly publication, Educating Physicians: A Call for Reform of Medical School and Residency 2012 Visiting professorships – seven in 2012

C. Selected Peer-reviewed Publications

1. Lurie P, Bishaw M, Chesney MA, Cooke M Fernandes MEL, Hearst N, Kantongole-Mbidde E, Koetsawang S, Lindan CP, Mandel J, Mhloyi M, Coates TJ. Ethical, behavioral, and social aspects of HIV vaccine trials in developing countries JAMA 1994; 271 (4): 295-301. PMID: 8295289

2. Lesky L, Davis A, Cooke M. How did we make the interdisciplinary generalist curriculum work? - National efforts to facilitate success. Academic Medicine 2001; 76:S26-S30. PMID: 11299167

3. Khademi S, Cooke M. Attitudes of rural and urban Iranian women toward menopause. Maturitas 2003; 46:113-21. PMID: 14559382

4. Cooke M, Irby DM, Debas HT. The UCSF Academy of Medical Educators. Academic Medicine 2003; 78:666-72. PMID: 12857682

5. Greene J, Yedidia MJ and the Take Care to Learn Collaborative. Provider behaviors contributing to patient self-management of chronic illness among underserved populations. J. Health Care Poor Underserved 2005; 16: 808-824. PMID: 16311500

6. Cooke M, Irby DM, Sullivan W, Ludmerer KM. American medical education one hundred years after the Flexner report. New Engl J. Med. 2006; 355:1339-44. PMID: 17005951

7. Public Policy Committee of the American College of Physicians: Ginsburg JA, Doherty RB, Ralston JF, Senkeeto N, Cooke M, Cutler C, Fleming DA, Freem BP, Gluckman RA, Liebow M, McLean RM, Musana KA, Nichols PM, Purtle MW, Reynolds PP, Weaver KM, Dale DC, Levine JS, Stubbs JW. Achieving a high-performance health care system with universal access: what the United States can learn from other countries. Ann Intern Med 2008; 148:55-75. PMID: 18056654 8. Sullivan W, Cooke M, Colby A, Sutphen M, O’Brien B. “Exploring common dilemmas in the preparation of professionals: What can we learn from professional education in five fields?” Research Symposium. American Educational Research Association, New York City, NY, March 2008.

9. Lubinski C, Aberg J, Bardequez AD, Elion R, Emmanuel P, Kuritzkes D, Saag M, Squires KE, Weddle A, Rainey J, Zerehi MR, Ralston JF, Fleming DA, Bronson D, Cooke M, Cutler C, Ejnes Y, Gluckman R, Liebow M, Musana K, Mayer ME, Purtle MW, Reynolds PP, Viswanathan L, Weiss KB, Yehia B. HIV policy: The path forward – A joint position paper of the HIV Medicine Association of the Infectious Diseases Society of America and the American College of Physicians. Clin Infect Dis 2009; 48:1335-44. PMID: 19385087

10. Cooke M. Cost consciousness in patient care – what is medical education’s responsibility? New Engl J Med 2010; 362(14):1253-1255. PMID: 20357275 PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

11. Irby DM, Cooke M, O’Brien BC. Calls for reform by The Carnegie Foundation for the Advancement of Teaching: 1910 and 2010. Acad Med 2010; 85(2):220-7. PMID: 20107346

12. Cooke M, Ironside PM, Ogrinc GS. Mainstreaming quality and safety: A reformulation of quality and safety education for health professions students. Cliveden International Colloquium on the Epistemology of Improving Quality BMJ: Quality and Safety (formerly Quality and Safety in Health Care) 2011; 20 (Suppl. 1): i79-i82. PMID: 21450779

13. Cooke M. Expert patients – learning from HIV. Cliveden International Colloquium on the Epistemology of Improving Quality BMJ: Quality and Safety (formerly Quality and Safety in Health Care) 2011: 20 (Suppl. 1): i67-i68. PMID: 21450776

14. Miceli A, Sebuyira LM, Crozier I, Cooke M, Omwangangye P, Rayko-Farrar L, Ronald A, Tumwebaze M, Willis K, Weaver MR. Advances in clinical education: A model for infectious disease training for non-physician clinicians in Uganda. Int J Infect Dis 2012; 16(10):e708-13. .

15. Cooke M, Irby DM, O’Brien BC. Educating Physicians: A Call for Reform of Medical School and Residency. Jossey-Bass/Wiley, San Francisco, CA. May 2010. (Book)

D. Research Support No current research grants

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Craik, Charles S. Professor eRA COMMONS USER NAME (credential, e.g., agency login) ccraik EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Allegheny College, Meadville, PA B.Sc. 1972-1976 Chemistry Columbia University, New York, NY M.A. 1976-1978 Chemistry Columbia University, New York, NY Ph.D. 1978-1981 Chemistry University of California, San Francisco, CA Postdoc 1981-1985 Biochem & Biophysics

A. Personal Statement The research interests of the Craik lab focus on defining the roles and the mechanisms of enzymes in complex biological processes and on developing technologies to facilitate these studies. Information on the lab can be found at the following website: http://www.craiklab.ucsf.edu/. The primary emphasis of our work has been on enzymes, with a particular emphasis on macromolecular recognition. Our original protein engineering studies have evolved to encompass various proteases as well as their endogenous inhibitors and membrane bound receptors, including uPAR, and have recently been successful at developing functional imaging probes for breast, colon, and prostate cancer using novel technologies. Our antibody engineering studies have identified Fabs that recognize conformational states of the target enzyme or receptor and were developed into functional probes for in vivo imaging (248, 280, 281, 287). The methodologies we developed to identify these functional Fabs have also been applied to enzymes and membrane proteins to facilitate structural and functional studies (226, 268, 271, 273) and are the basis of the current proposal. The proposed research of Project 1 and the Antibody Core of this Center—to identify and develop Fabs to study transporter structure and function—takes advantage of the experience that my lab has in biochemistry and molecular protein engineering and capitalizes on productive collaborations already in place with the Stroud, Cheng, Kroetz and Sali labs.

B. Positions and Honors Academic Positions 1985-91 Asst. Professor, Depts. of Pharm. Chemistry and Biochem. & Biophysics, UCSF 1991-1994 Assoc. Professor, Depts. of Pharm. Chemistry and Biochem. & Biophysics, UCSF 1994-present Professor, Depts. of Pharm. Chemistry, and Biochem. & Biophysics, UCSF 1995-present Professor, Depts. of Pharm. Chemistry, Pharmacology and Biochem. & Biophysics, UCSF 1997-present Member of the UCSF AIDS Institute 1998-present Member of the UCSF Comprehensive Cancer Center 1999-present Director, Chemistry and Chemical Biology Graduate Program 2010-present Director, Quantitative Biosciences Consortium of Graduate Programs Other Experience and Professional Memberships 1983-pres. Member, American Society of Biological Chemists 1987-97 Editorial Board Member of BioTechniques 1988 Editorial Board Member of DNA 1988-03 Associate Editor of Protein Engineering 1989-90 Nominating Committee for the Protein Society, Member, The Protein Society 1993-96 National Science Foundation Molecular Biochemistry Advisory Panel 1996 Vice Chair of Gordon Conference on Proteolytic Enzymes and Inhibitors 1998 Chairman of Gordon Conference on Proteolytic Enzymes and Inhibitors 1997, 99, 01 Co-organizer of the Cold Spring Harbor Meeting on the Biology of Proteolysis 2009 NIH/NIAID, Study Section Member (B. Lange-Gustafson, Ph.D. SRO) 2009 NIH, Center for Scientific Review Member (M. Rigas, Ph.D. SRO)

2012 NIH/NIAID Special Emphasis Panel (R.C. Unfer, Ph.D., SRO) 2012 NIH/NCI Board of Scientific Counselors Review Panel (F. Farber, Ph.D., SRO) 2013 NIH/HHS Study Section Member ZRG1 BCMC-B (D. Schneider, Ph.D., SRO) 2014 NIH/Synthetic and Biol Chem B Study Section Member (K. Koeller, Ph.D., SRO) Honors Top 100 Innovators - Science Digest (1985-86) Henry Kamin Memorial Lecture, Duke University Medical Center, Durham, NC (1998) POSH Lecturer, Immunex Corporation, Seattle, WA (2000) Council of Experts, United States Pharmacopeia (2009-present) Lord Lecturer, Allegheny College, Meadville, PA (2010) Fellow of the American Association for the Advancement of Science (2011) Academy of Sciences of the Czech Republic medal in Organic Chemistry and Biochemistry (2013)

C. Selected peer-reviewed publications most relevant to the current application. Selected from 290 226. Structure of an Fab-Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition. Farady, C.T., Egea, P.F., Schneider, E.L., Darragh, M.R., Craik, C.S. J Mol Biol. 2008; 380(2), 351-60 PMCID: PMC2478700. 248. Tumor detection by imaging proteolytic activity. Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Cancer Res. 2010; 70(4):1505-12. PMCID: PMC2823079. 253. Antagonistic anti-uPAR antibodies significantly inhibit uPAR-mediated cellular signaling and migration. Duriseti KS, Goetz DH, Hostetter DR, Wei Y, Craik CS. J Biol Chem. 2010;285(35):26878-88. PMCID: PMC2930687. 268. Rapid identification of recombinant Fabs that bind to membrane proteins. Kim J, Stroud RM, Craik CS. Methods. 2011;55(4):303-9. PMCID: PMC3264787 271. A Reverse Binding Motif that Contributes to Specific Protease Inhibition by Antibodies. Schneider E, Lee M, Baharuddin A, Goetz D, Farady C, Ward M, Wang C-I, Craik CS. J Mol Biol 2011;415(4):699-715. PMCID: PMC3268006. 273. Fabs enable single particle cryoEM studies of small proteins. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Structure 2012 Apr 4;20(4):582-92. PMID: 22483106, PMCID: PMC3322386 278. Global identification of peptidase specificity by multiplex substrate profiling. O'Donoghue AJ, Eroy- Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, DeRisi JL, McKerrow JH, Burlingame AL, Craik CS. Nature Methods 2012 Nov;9(11):1095-100. PMCID: PMC3707110 280. Imaging a functional tumorigenic biomarker in the transformed epithelium. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, Vanbrocklin HF, Craik CS. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):93-8. PMCID: PMC3538269. 281. Targeting uPAR with Antagonist Recombinant Human Antibodies in Aggressive Breast Cancer. LeBeau A, Duriseti S, Murphy S, Pepin F, Hann B, Gray J, VanBrocklin H and Craik CS, Cancer Research. 2013 Apr 1;73:2070-81 PMID 23400595. PMCID: PMC3618559. 287. Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. Lebeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, Vanbrocklin HF. Theranostics 2014 Jan 18;4(3):267-79. doi: 10.7150/thno.7323. eCollection 2014. PMCID: PMC3915090 Additional recent publications of importance to the field (in chronological order) 235. Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor. Shahian, T., Lee, G., Lazic, A., Arnold, L., Velusamy P., Roels C, Guy R., Craik, C.S. Nat Chem Biol.,5(9):640-6 (2009) PMCID: PMC2752665. 236. Trapping Moving Targets With Small Molecules, Lee G and Craik CS. Science. 2009; 10;324(5924):213-5 PMCID: PMC2981433. 254. Prediction of Protease Substrates Using Sequence and Structure Features. Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Bioinformatics. 2010 May 26; 26(14):1714-22. PMCID: PMC2894511.

264. Enzyme inhibition by allosteric capture of an inactive conformation. Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. J Mol Biol. 411(5):999-1016 (2011) PMCID: PMC3157250. 269. Global Landscape of HIV-Human Protein Complexes. Jäger S, Cimermancic P, Gulbahce N, Johnson J, McGovern K, Clarke S, Shales M, Mercenne G, Li K, , Jang G, Akiva E, Pache L, Marlett J, Roth S, Stephens M, D’Orso I, Fernandes J, Fahey M, Mahon C, O’Donoghue A, Todorovic A, Morris J, Maltby D, Alber T, Cagney G, Bushman F, Young J, Chanda S, Sundquist W, Kortemme T, Hernandez R, Hernandez, H, Craik CS, Burlingame A, Sali A, Frankel A, Krogan N. Nature 2011; 481(7381):365-70. PMCID: PMC3310911.

D. Research Support Ongoing Research Support R01 GM104659 (Craik, PI) 07/10/13-03/31/17 Allosteric Inhibition of a Family of Proteolytic Enzymes The aim of this project is to identify and develop allosteric inhibitors that trap inactive conformations of a family of proteolytic enzymes associated with human herpes viruses that have sufficient pharmacologic viability to serve as the starting point for lead optimization and animal studies.

R21 CA186077 (Craik, PI) 04/01/2014 – 03/31/2016 NIH Extracellular Proteolysis as a Molecular Stratification Tool for Cancer Advancements in the diagnosis and monitoring of cancer require new technologies that can define disease at the molecular level. Proteases are a class of proteins that are essential molecular players in normal cellular function but also are responsible for the spread of aggressive cancer when they become unregulated. We are developing a highly sensitive technology that can report on protease function in cancer to both improve our understanding of cancer progression and aid in the identification and treatment of cancer in patients.

P50 GM082250 (Frankel, PI; Craik, Co-investigator) 09/20/12-08/31/17 HARC Center: HIV Accessory and Regulatory Complexes. This project aims to validate and characterize HIV-Host complexes identified by tandem affinity purification and mass spectrometry. Select protein complexes are expressed in suitable expression systems for each protein complex after optimizing the clones at the nucleic acid level. Protocols are then established to produce reagent quantities of the desired complexes to determine the virological role of the complexes. Our initial emphasis is on the nucleic acid and protein complexes of HIV regulatory and accessory proteins including HIV protease, Integrase, Vpr and Vif.

P50 GM073210 (Stroud, PI; Craik, Co-investigator) 09/24/04-08/31/14 Membrane Protein Expression Center: Antibody Assisted Crystallization. The aim of this subproject is to develop methods for screening and identifying fragments of antibodies from a highly diverse bacteriophage display library to be used in the structural characterization of membrane proteins using electron microscopy and x-ray crystallography.

U54 HG006436 (PI: Kossiakoff; Co-PI’s: Craik, Wells, Sidhu, Marks) 09/26/11-08/31/16 Recombinant Antibody Network (RAN): Production of Affinity Reagents for Human Transcription Factors The RAN is a consortium of three recombinant antibody production centers at UChicago, UToronto and UCSF. All three are contributing to generating recombinant antibodies to the ~1500 existing human transcription factors.

W81XWH-12-1-0440 (Craik, PI) 09/01/12—08/31/15 DOD Novel Imaging Biomarkers for Aggressive Prostate Cancer Assess the in vitro and in vivo properties of a new class of protease biosensors to create better agents for imaging and quantifying proteolysis in breast cancer before and during treatment. Role on Project: Principal Investigator

T32 GM064337 (Craik, PI) 07/01/02-06/30/17 Research Training in Chemistry and Chemical Biology. The aim of this predoctoral training program in Chemistry and Chemical Biology is to foster research that will exploit and develop chemical strategies to understand and control fundamental biological processes. The research has direct relevance to national priorities in human health, and addresses central problems in chemical biology. Although I am the PI of the grant and administer it, I receive no direct funding from this training grant.

Pending:

R21 CA185689 (PI: Craik) 09/01/2014-08/31/2016 NIH Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer To improve the specificity and durability of novel protease-activated fluorescent and positron-emission tomography probes for detection of pancreatic ductal adenocarcinoma (PDAC). The probes will be applied to a mouse model of PDAC to define and localize the active proteases during the evolution of PDAC over time for eventual development of a PET imaging agent.

Program Director/Principal Investigator (Last, First, Middle):Dandu, Madhavi

NAME POSITION TITLE Dandu, Madhavi Associate Professor of Medicine eRA COMMONS USER NAME (credential, e.g., agency login) dandum EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Michigan BA 05/97 Biomedical Sciences and Comparative Literature

University of Michigan Medical School MD 06/00 Medicine

University of California, San Francisco Residency 6/03 Internal Medicine

University of California, Berkeley MPH 5/04 Public Health with International Concentration

A. Personal Statement

My main work, outside of clinical work, over the last five years has been in global health education. Through my positions as Director of the Global Health Area of Distinction for the Internal Medicine Residency Program, Associate Director of the Pathways to Discovery Program in Global Health, and as the Program Director for the Masters of Science in Global Health, I have extensive experience with educational program development, curriculum development, teaching, fieldwork mentorship, career mentorship, and trainee evaluation. Along with colleagues I oversee and assist with the formal training of over 60 global health trainees per year. In that role I have supervised capstone projects for over 100 trainees and been present and evaluated all of their qualifying and comprehensive examinations. Outside of my global health work I also mentor five to six internal medicine trainees and two junior faculty per year. Additionally I sit on multiple research review committees for proposals. In all of my roles I have reviewed more than 150 project proposals that focus on creating sustainable research projects and partnerships. I have additional training in epidemiology, biostatistics, and population health from by MPH work that will be helpful for supporting the PhD program.

B. Positions and Honors

Positions and Employment

2004- 2006 Clinical Instructor, University of Michigan, Department of Internal Medicine, Ann Arbor, MI 2006- 2013 Assistant Clinical Professor, University of California, San Francisco, Department of Medicine, San Francisco, CA 2013- present, Associate Professor of Clinical Medicine, University of California, San Francisco, Department of Medicine, San Francisco, CA

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):Dandu, Madhavi

Other Positions Held Concurrently

2006-2010 Academic Coordinator, Interdisciplinary MPH Program, School of Public Health, University of California, Berkeley, Berkeley, CA 2007-present Director, Global Health Pathway, Internal Medicine Residency Program, University of California, San Francisco, San Francisco, CA 2007-2012 Director, International Electives Program, Internal Medicine Residency Program, University of California, San Francisco, San Francisco, CA 2008-present Associate Director, Pathways to Discovery in Global Health, University of California, San Francisco, San Francisco, CA 2009-2011 Fieldwork and Mentorship Director, Masters of Science in Global Health, Global Health Sciences, University of California, San Francisco, San Francisco, CA 2011- 2013 Associate Program Director, Masters of Science in Global Health, Global Health Sciences, University of California, San Francisco, San Francisco, CA 2013-2014 Interim Program Director, Masters of Science in Global Health, Global Health Sciences, University of California, San Francisco, San Francisco, CA 2014- Present Program Director, Masters of Science in Global Health, Global Health Sciences, University of California, San Francisco, San Francisco, CA

Relevant Professional Memberships

2007-2011 Member, Global Health Education Consortium 2009-2010 Member, American Society of Tropical Medicine and Hygeine 2009-present Member, Consortium of Universities for Global Health 2014 Inducted as member of the Academy of Medical Educators, UCSF

Relevant Honors and Awards

1997 Magna Cum Laude, Bachelor of Science, University of Michigan 1998 Novartis Award for Outstanding Community Service, University of Michigan Medical School 1999 Medical School Recognition for Women for Outstanding Achievement, University of Michigan Medical School 1999 Alpha Omega Alpha, University of Michigan Medical School 2003 University Fellowship, University of California, Berkeley

C. Selected Peer Reviewed Publications

1. Bump GM, Dandu M, Kaufman SR, Shojania KG, Flanders SA. J Hosp Med. 2009 May;4(5):289- 97. Gupta R, Dandu M, et al. Depression in Botswana: A Population-based Study on Gender-specific Socioeconomic and Behavioral Correlates. PLoS One 2010; 5(12):e14252. Iacopino V, Weiser S, Dandu M, and Tuller D. HIV/AIDS and Human Rights in Botswana and Swaziland: A Matter of Dignity and Health. Hastings International and Comparative Law Review. Volume 34, No.1 – WINTER 2011. 4. Dandu, M. Trainee Safety in Global Health. Journal of General Internal Medicine. 2011 Aug;26(8):826–7. 5. Kohwles JR, Cornett P, Dandu M, et al. Developing Educators, Investigators, and Leaders During Internal Medicine Residency: The Area of Distinction Program. Journal of Graduate Medical Education. December 2011. 6. Parikh R, Frost N, Green A, Dandu M. A Leathery Lining. J Gen Intern Med. 2014 Jan;29(1):243

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):Dandu, Madhavi 7. Nagatha J, Cohen C, Young S, Wamuyu C, Armes M, Benard O, Leslie H, Dandu M, Bukusi E, Weiser S. Descriptive characteristics and health outcomes of the Food by Prescription nutrition supplementation program for adults living with HIV in Nyanza Province, Kenya. PLOS One March 2014, Volume 9, Issue 3

D. Research Support

No extramural research support

NAME POSITION TITLE Dawson Rose, Carol Sue Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) crdawson

A. Positions and Honors Positions and Employment 2000-2006 Assistant Adjunct Professor, Department of Community Health Systems, University of California, San Francisco, School of Nursing 2000-present Nurse Director, Pacific Region AIDS Education and Training Center, Department of Family and Community Medicine, University of California, San Francisco 2004-2007 Volunteer Faculty, Culture and Behavior Curricula, Department of Medicine, University of California, San Francisco 2006-2008 Associate Adjunct Professor, Department of Community Health Systems, University of California, San Francisco, School of Nursing 2008-present Core Faculty, Center for AIDS Prevention Studies, School of Medicine, University of California, San Francisco 2009-present Associate Professor, Department of Community Health Systems, University of California, San Francisco, School of Nursing 2011-present Advanced Practice Public Health Nursing Specialty Director, School of Nursing, University of California, San Francisco

Honors 2002 International Women's Day Award, Center for AIDS Prevention Studies, University of California-San Francisco 2005 Champion of Diversity, University of California-San Francisco Office of Affirmative Action, Equal Opportunity and Diversity 2011 Fellow, American Academy of Nursing 2013 Health Commission Award Wellness Team, SFDPH, Laguna Honda Hospital 2014 Leadership Hall of Fame, UCSF, Sigma Theta Tau International, Alpha Eta Chapter

B. Selected Peer-Reviewed Publications 1. Dawson Rose, C.S., Shade, S.B., Lum, P.J., Knight, K.R., Purcell, D.P., & Parsons, J. The Health Care Experience of HIV Positive Injection Drug Users. Journal of Multicultural Nursing and Health, 11(1) Winter, 23-30, 2005. 2. Knowlton, A.R., Arnsten, J.H., Gourevitch, M.N., Eldred, L., Wilkinson, J.D., Rose CD, et. al. Microsocial environmental influences on highly active antiretroviral therapy outcomes among active injection drug users: the role of informal caregiving and household factors. Journal of Acquired Immune Deficiency Syndrome, 46 (Supplement 2), S110-9, 2007. 3. Rivero-Méndez M, Dawson-Rose CS, Solís-Báez SS. A Qualitative Study of Providers' Perception of Adherence of Women Living with HIV/AIDS in Puerto Rico. Qual Rep. 2010 Mar 1;15(2):232-251 4. Rose CD, Courtenay-Quirk C, Knight K, Shade SB, Vittinghoff E, Gomez C, Lum PJ, Bacon O, Colfax G. HIV intervention for providers study: a randomized controlled trial of a clinician-delivered HIV risk-reduction intervention for HIV-positive people. J Acquir Immune Defic Syndr. 2010 Dec 15; 55(5):572-81. PMID: 20827218 5. Dawson-Rose, CS, Gutin, SA & Reyes, M. Adapting Positive Prevention Interventions for International Settings: Applying U.S. Evidence to Epidemics in Developing Countries. J Assoc Nurses AIDS Care 2011; 22(1):38-52. 6. Webel, AR; Phillips, JC; Dawson-Rose, C, et al. A Cross-Sectional Description of Social Capital in an International Sample of Persons Living with HIV/AIDS (PLWH). BMC Public Health. 2012 Mar 13;12(1):188 [Epub ahead of print]. 7. Kemppainen JK, Brion JM, Leary M, Wantland D, Sullivan K, Nokes K, Bain CA, Chaiphibalsarisdi P, Chen WT, Holzemer WL, Eller LS, Iipinge S, Johnson MO, Portillo C, Voss J, Tyer-Viola L, Corless IB, Nicholas PK, Rose CD, Phillips JC, Sefcik E, Mendez MR, Kirksey KM. Use of a brief version of the self- compassion inventory with an international sample of people with HIV/AIDS. AIDS Care. 2013 Mar 25. [Epub ahead of print] 8. Christopoulos, KA, Massey, AD, Lopez, AM, Geng, EH, Johnson, MO, Pilcher, CD, Fielding, H, Dawson- Rose, C. "Taking a half day at a time:" patient perspectives and the HIV engagement in care continuum. AIDS Patient Care and STDs. 2013 Apr;27(4):223-30. 9. Zhao L, Holzemer WL, Tulsky JP, Johnson MO, & Dawson Rose, C. Effect of methadone dose on maintenance treatment and health consequences among heroin addicts in South China. Substance Use and Misuse. 2014; 49(1-2):13-21. 10. Phillips, J. C., Webel, A., Dawson Rose, C., Corless, I. B., Sullivan, K. M., Voss, J., Wantland, D., Nokes, K., Brion, J., Chen, W. T., Iipinge, S., Eller, L. S., Tyer-Viola, L., Rivero-Mendez, M., Nicholas, P. K., Johnson, M. O., Maryland, M., Kemppainen, J., Portillo, C. J., Chaiphibalsarisdi, P., Kirksey, K. M., Sefcik, E., Reid, P., Cuca, Y., Huang, E., & Holzemer, W. L. Associations between the legal context of HIV, perceived social capital, and HIV antiretroviral adherence in North America. BMC Public Health. 2013; 13:736. PMID: 23924399. 11. Gutin, S, Cummings, BA, Jainatilal, P, Johnson, K, Mbofana, F, & Dawson Rose, CS. Qualitative Evaluation of Positive Prevention Program for Health Care Providers in Mozambique. Evaluation and Program Planning. http://dx.doi.org/10.1016/j.evalprogplan.2013.10.006 12. Dawson Rose, C., Webel, A., Sullivan, K. M., Cuca, Y. P., Wantland, D., Johnson, M. O., ... & Holzemer, W. L. (2014). Self‐ Compassion and Risk Behavior Among People Living With HIV/AIDS. Research in Nursing & Health, 37(2), 98-106. 13. Hilliard, S., Gutin, S., & Dawson Rose, C. Messages on pregnancy and family planning that providers give women living with HIV in the context of a Positive Health, Dignity and Prevention intervention in Mozambique. International Journal of Women's Health. (In Press). 14. Dawson Rose, C., Gutin, S.A., Cummings, B., Jaiantilal, P., Johnson, K., & Mbofana, F. ART adherence as a key component of Positive Prevention: Accounts on the implementation of HIV prevention in care. (In Review) 15. Cummings, B., Gutin, S., Jaiantilal, P., Correia, D., Malimane, I., & Dawson Rose, C. "Let's go together:" The role of social support among PLHIV in rural Mozambique. AIDS Patient Care and STDs. (In review)

C. Research Support On-going Research Support U2G-PS002770-01 09/30/2010-09/29/2015 Development and Implementation of HIV Positive Prevention Interventions in Mozambique. The purpose of the partnership between the CDC Mozambique, I-TECH Mozambique and the School of Nursing, UCSF is to adapt evidence based PP intervention into the context of Mozambique, implement a curriculum in seven provinces and evaluate the implementation. Role: C.S. Dawson-Rose, PI 656-A-00-10-00206-00 08/01/2010-07/31/2014 combination Prevention for the General Population of Adults and Youth, including Persons Living HIV in Mozambique. As part of a large HIV Prevention initiative for Mozambique, we are developing a strategy for addressing HIV prevention with HIV-infected persons living in Mozambique. (JH University Sub-Award) Role: Subcontractor UCSF Medical Center Department of Nursing and School of Nursing 07/01/2013-06/30/2014 Screening and Treatment for HCV in HIV Co-Infected Patients in Primary Care The purpose of this project is to determine the prevalence of HCV/HIV co-infected patients who are eligible for HCV treatment in an HIV primary care clinic; and to assess the feasibility of implementing an Integrated HCV Treatment Protocol into HIV primary care setting. Role: PI

Completed Research Support 1RC1DA028224-01 09/30/2009-08/31/2011 NIH, Dept. of Health and Human Services Impact of a Computer-Assisted SBIRT Program in an HIV Care Setting The purpose of this study is to institute screen for harmful use of alcohol, tobacco and other substance use in an HIV primary care clinic setting. RCT compare clinician administered to computer administered screening and brief interventions for harmful substance use. Compare levels of self-reported substance use and urine toxicology testing. Role: C.S. Dawson-Rose, PI U91HA06801 (UW Subcontract) 09/01/2009-08/30/2010 implementation of HIV Positive Prevention +Positives Interventions in Mozambique The purpose of the contract was to continue work between the CDC Mozambique and the School of Nursing, UCSF on the Positive Prevention activities in Mozambique. The project moved to I-TECH as part of scale up of Mozambique national roll out of training for health care workers. Role: Principal Investigator H-F3-MOZ-07-PTR-PWPS 09/01/2006-08/30/2010 AIHA Twinning Center Development and Implementation of HIV Prevention with Positives Interventions in Mozambique The purpose of the Twinning partnership between the CDC Mozambique and the School of Nursing, UCSF is to adapt evidence based PwP intervention into the context of Mozambique, implement a curriculum and evaluate the implementation. Role: Principal Investigator 2 D09HP03285-04 Portillo (PI) 07/01/2007-06/30/2010 HRSA, Division of Nursingv Positive Health: Advanced Nurse Practice Education Advance Practice Nurse Education grant to expand upon existing academic and clinic programs that prepares expert adult nurse practitioner and clinical nurse specialist in HIV/AIDS. Role: Co-Investigator R18/CCR 920974 09/30/2001-09/29/2006 CDC Prevention Services Research Branch Providing Prevention: An Intervention for HIV Medical Providers. As PI of this study I directed all scientific operations of the study. Our team developed an evidence-based intervention for HIV infected persons. Intervention is to train primary care providers to address prevention within the setting of HIV care. This study is the basis of my Mozambique project. Role: PI

Haile T. Debas, M.D. Senior Global Health Advisor, UCSF Director, University of California Global Health Institute

Haile T. Debas is recognized internationally for his contributions to academic medicine and is widely consulted on issues associated with global health. At the University of California, San Francisco, he served as the Founding Executive Director of UCSF Global Health Sciences (2003-2010), Dean of the School of Medicine (1993-2003), Vice Chancellor of Medical Affairs (1998–2003), and Chancellor (1997- 1998). A gastrointestinal surgeon by training, Dr. Debas chaired the UCSF Department of Surgery (1987- 2003), and is the Maurice Galante Distinguished Professor of Surgery, Emeritus. He also is the Founding Director of the University of California Global Health Institute. He was instrumental in the creation of the Consortium of Universities for Global Health and served as the Founding Chair of its Board of Directors (2009-2012).

A native of Eritrea, Dr. Debas received his M.D. from McGill University and completed his surgical training at the University of British Columbia (UBC) and post-doctoral fellowship at UCLA. He has held faculty positions at UBC, UCLA, and the University of Washington. Under Dr. Debas’ stewardship, the UCSF School of Medicine became a national model for medical education, an achievement for which he was recognized with the 2004 Abraham Flexner Award for Distinguished Service to Medical Education by the Association of American Medical Colleges (AAMC).

His prescient grasp of the implications of fundamental changes in science led him to create several interdisciplinary research centers that have been instrumental in reorganizing the scientific community at UCSF. He played a key role in developing UCSF’s new campus at Mission Bay. He has held leadership positions with numerous membership organizations and professional associations, including serving as president of the American Surgical Association and Chair of the Council of Deans of the AAMC. He served for two terms as a member of the Committee on Science, Engineering, and Public Policy of the National Academy of Sciences; served four years on the Advisory Committee to the Director of the National Institutes of Health; and was a member of the United Nations’ Commission on HIV/AIDS and Governance in Africa. He is a member of the Institute of Medicine, and served as chair of the Membership Committee.

Dr. Debas is a fellow of the American Academy of Arts and Sciences. He currently serves on the Board of Regents of the Uniformed Services University of the Health Sciences and the Board of Trustees of the Aga Khan University. He is a lead editor of the forthcoming Essential Surgery volume of Disease Control Priorities in Developing Countries, Third Edition (DCP3). In 2012, Dr. Debas was awarded the UCSF Medal for his academic and leadership contributions to the University.

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Dohan, Daniel Paul Professor of Health Policy and Social Medicine in eRA COMMONS USER NAME Residence ddohan EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Harvard College, Cambridge MA AB 1987 Sociology University of California Berkeley MA 1991 Sociology University of California Berkeley PhD 1997 Sociology University of California Berkeley post-doc 1999 Health Policy University of California Berkeley post-doc 2001 Health Policy

A. Personal Statement

Background: My training is in sociology (emphasis on culture and inequality) and health policy. My research uses comparative qualitative research to examine how the culture of medicine shapes health care delivery. My current studies use a combination of focus groups, in-depth interviews, participant- observation, and survey methods. Research: I am leading two primary research projects. I am PI for the Cancer Patient Deliberation study, an NCI-funded R01 examining how patients with advanced cancer make decisions about treatment and participation in clinical trials. I am Program Director for EngageUC – a three-year CTSA initiative to develop harmonized processes for biospecimen repository data collection and analysis across all five University of California campuses with medical centers. EngageUC includes a statewide community engagement activity as well as a randomized trial of different consenting methods. Teaching/Mentoring: At UCSF, I teach qualitative research methods, mentor post-doctoral scholars and junior faculty members on career development awards, and lead training and program development as Associate Director at the Institute for Health Policy Studies. Leadership and Administration: As Associate Director of the Institute for Health Policy Studies and co- Director of the UCSF-UC Hastings Consortium on Law, Science and Health Policy, I have responsibilities for developing new programs in education, research, and clinical/service. These include programs to translate research into law and policy; partnerships to provide legal services to vulnerable populations including children and seniors; and new degree programs including a Masters of Science in Health Policy and Law.

B. Positions and Honors

Positions and Employment 1986-87 Research Assistant, Professor Mary-Jo Delvecchio Good, Department of Social Medicine, Harvard Medical School, Boston MA 1987-89 Research Assistant/Junior Analyst, Health Research Area, Abt Associates, Cambridge MA 1990-92 Research Assistant, Professor Michael Hout, University of California (UC) Berkeley 1993 Teaching Assistant, Minority Opportunities in Sociological Training (MOST), American Sociological Association, Berkeley CA 1996-97 Teaching Assistant, Department of Sociology, UC Berkeley , 1996-1997. 1997-99 Robert Wood Johnson Foundation Scholar in Health Policy Research, UC Berkeley 1999-present Associate, Center for Urban Ethnography, UC Berkeley

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1999-2001 Post-Doctoral Research Fellow in Alcohol Studies, Alcohol Research Group, School of Public Health, UC Berkeley 2002- 08 Assistant Adjunct Professor, Institute for Health Policy Studies and Department of Anthropology, History and Social Medicine, UC San Francisco 2008- 2010 Director, UCSF Pathway to Discovery in Health and Society 2008- 2013 Associate Professor, Institute for Health Policy Studies and Department of Anthropology, History and Social Medicine, UCSF 2009- 2012 Associate Director, UCSF/UC Hastings Consortium on Law, Science and Health Policy 2005- present Associate Director for Training and Development, Institute for Health Policy Studies, UCSF 2012- present Co-Director, UCSF/UC Hastings Consortium on Law, Science and Health Policy 2013- present Professor, Institute for Health Policy Studies and Department of Anthropology, History and Social Medicine, UCSF

Other Experience and Professional Memberships 2003-present Member, UCSF Comprehensive Cancer Center; Center for Health and Community 2003-present Advisory Board, CARE (Cancer Awareness Resources and Education) SF General Hospital 2008- present Course Director, Qualitative Research Methods, Training in Clinical Research Program 2010-present Advisory Board: UCSF Participant Recruitment Services; Training in Clinical Research Program 2011-present NIH Study Section Review: Early Phase Chemoprevention Network; SBIR/STTR Stage 1; PCORI Study Section 10 (co-chair)

Honors 1987 AB Magna cum Laude with Highest Honors in Sociology, Harvard College, Cambridge MA 1987 Hoopes Prize, Senior Honors Thesis “Malpractice in Massachusetts: Physicians’ Perspectives,” Harvard College 1989 Regents Intern-Fellow, UC Berkeley 1994 Carol Hatch Ethnography Award, UC Berkeley Sociology Department 1998 Outstanding Graduate Student Instructor, UC Berkeley 2006 UCSF-Coro Faculty Leadership Collaborative

C. Selected peer-reviewed publications Book 1. Dohan, Daniel. 2003. The Price of Poverty: Money, Work, and Culture in the Mexican-American Barrio. Berkeley, CA: University of California Press. (book) Articles 2. Dohan, Daniel and Martín Sánchez-Jankowski. 1998. "Using Computers to Analyze Ethnographic Field Data: Theoretical and Practical Considerations." Annual Review of Sociology. 465-486 3. Dohan, Daniel. 2002. "Making Cents in the Barrios: The Institutional Roots of Joblessness in Mexican America." Ethnography 3: 209-232. 4. Dohan, Daniel. 2002. "Managing Indigent Care: A Case Study of a Safety-Net Emergency Department." Health Services Research 37: 361-376. 5. Schmidt, Laura, Daniel Dohan, James Wiley, and Denise Zabkiewicz. 2002. "Addiction and Welfare Dependency: Interpreting the Connection." Social Problems 49: 221-241. 6. Dohan, Daniel and Deborah Schrag. 2005. "Using Navigators to Improve Care of Underserved Patients: Current Practices and Approaches" Cancer. 104:4 848-55 7. Dohan, Daniel, Laura Schmidt, and Stuart Henderson. 2005. "From Enabling to Bootstrapping: Welfare Workers' Views of Substance Abuse and Welfare Reform" Contemporary Drug Problems. 32: 429-455. 8. Henderson, Stuart, Daniel Dohan and Laura Schmidt. 2006 "Barriers to Identifying Substance Abuse in the Reformed Welfare System" Social Service Review. 80:2. 217-38. 9. Schmidt, Laura, James Wiley, Daniel Dohan, Denise Zabkiewicz, Laurie Jacobs, Stuart Henderson, and Matt Zivot. 2006. "Changing Patterns of Addiction and Public Aid Receipt: Tracking the Unintended Consequences of Welfare Reform Policy." Journal of Health Politics, Policy and Law. 31:945-980

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10. Goldman, L. Elizabeth, Stuart Henderson, Daniel P. Dohan, Jason A. Talavera, and R. Adams Dudley 2007. "Public Reporting and Pay-for-performance: Safety-net Hospital Executives' Concerns and Policy Suggestions" Inquiry. 44:137-145 11. Dohan, Daniel and Marya Levintova. 2007. "Barriers beyond words: Cancer, Culture, and Translation in a Community of Russian-speakers." Journal of General Internal Medicine. 22(supp 2): 300-5 12. Henderson, Stuart, Clare Stacey, and Daniel Dohan. 2008. "Social Stigma and Dilemmas of Providing Care to Substance Users in a Safety-Net Emergency Department" Journal of Healthcare for the Poor and Uninsured. 19:4. 1336-49. 13. Joseph, Galen and Daniel Dohan. 2009. "Clinical Trials Enrollment in an Academic Medical Center: What Makes a 'Good Study Patient'?" Cancer. 11:2. 608-15. 14. Stacey, Clare, Stuart Henderson and Daniel Dohan. 2009. "Demanding Patient or Demanding Encounter?: A Case Study of a Cancer Clinic" Social Science and Medicine. 69:5. 729-37. 15. Joseph, Galen and Daniel Dohan. 2009. "Recruiting Minorities Where They Receive Care: Institutional Barriers to Cancer Clinical Trials Recruitment in a Safety Net Hospital" Contemporary Clinical Trials. 30:6. 552-559. 16. Guadagnolo BA, Dohan D, Raich P. Metrics for evaluating patient navigation during cancer diagnosis and treatment: crafting a policy-relevant research agenda for patient navigation in cancer care. Cancer. 2011 Aug; 117(15 Suppl):3565-74. 17. Dohan D, Szolarova R, Walcer B. How a cancer education group serves the underserved: 'Family' ties and battling cancer. Patient Educ Couns. 2012 May; 87(2):212-6. 18. Schenker Y, Crowley-Matoka M, Dohan D, Tiver GA, Arnold RM, White DB. I don't want to be the one saying 'we should just let him die': intrapersonal tensions experienced by surrogate decision makers in the ICU. J Gen Intern Med. 2012 Dec; 27(12):1657-65. PMID: 23011253 19. Niemasik EE, Letourneau J, Dohan D, Katz A, Melisko M, Rugo H, Rosen M. Patient perceptions of reproductive health counseling at the time of cancer diagnosis: a qualitative study of female California cancer survivors. J Cancer Surviv. 2012 Sep; 6(3):324-32. 20. Joseph G, Dohan D. Recruitment practices and the politics of inclusion in cancer clinical trials. Med Anthropol Q. 2012 Sep; 26(3):338-60. PMID: 23259347 21. Dunn LB, Fisher SR, Hantke M, Appelbaum PS, Dohan D, Young JP, Roberts LW. In press. “Thinking about it for somebody else”: Alzheimer’s disease research and proxy decisionmakers’ translation of ethical principles into practice.” Am J Geriatr Psychiatry. 22. Overton E, Appelbaum PS, Fisher SR, Dohan D, Roberts LW, Dunn LB. Alternative decision-makers' perspectives on assent and dissent for dementia research. Am J Geriatr Psychiatry. 2013 Apr; 21(4):346- 54. PMID: 23498381 23. Kaplan CP, Nápoles AM, Dohan D, Shelley Hwang E, Melisko M, Nickleach D, Quinn JA, Haas J. Clinical trial discussion, referral, and recruitment: physician, patient, and system factors. Cancer Causes Control. 2013 May; 24(5):979-88. PMID: 23420328 24. Schenker Y, White DB, Crowley-Matoka M, Dohan D, Tiver GA, Arnold RM. Accepted. “‘It hurts to know . . . and it helps’: Exploring how surrogates in the ICU cope with prognostic information.” Journal of palliative medicine. 25. Dohan D, McCuistion MH, Frosch DL, Hung DY, Tai-Seale M. Recognition as a patient-centered medical home: fundamental or incidental? Ann Fam Med. 2013 May-Jun; 11 Suppl 1:S14-8. PMID: 23690381

C. Research Support

NIH UL1 TR000004-07S2 (Johnston and Dubinett, co-PIs) 9/24/12 – 6/30/16 National Center for Advancing Translational Sciences (NCATS) Engaging University of California Stakeholders for Biorespository Research The goal of EngageUC is to develop harmonized processes for collecting and including outpatient remnant samples in biorespository studies at the five University of California campuses with medical centers. Role: Co-Program Director

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National Cancer Institute Before Consent: Cancer Patients' Deliberations about Early Phase Clinical Trials This project uses mixed qualitative and quantitative methods to examine how cancer patients make decisions about participating in early phase trials of new cancer therapies. Role: Principal Investigator

Completed Research Support

NIH ULI RR024131 (Grumbach and Schmidt, component co-PIs) 10/1/07 – 6/30/12 Clinical and Translational Science Award (CTSI) Community Engagement and Health Policy (CE/HP) Program This project uses qualitative research methods to evaluate the success of new partnerships between UCSF CTSI, government, and community groups that aim to improve public health in San Francisco. Role: Co-Investigator

D55HP05165 (Bindman) 7/1/05-6/30/11 Health Resources and Services Administration Faculty Development in Primary Care The major goal for this project is to develop high quality academic general internists who are skilled in primary care research and are prepared to address research questions related to health and health care disparities. Role: Co-Investigator

AHRQ R18 HS019167 (Tai-Seale) 10/01/10-07/31/12 Agency for Healthcare Research and Quality Primary Care Transformation in a NCQA Certified Patient-Centered Medical Home The study uses mixed methods research methods to examine and evaluate changes in processes, health outcomes, and costs linked to efforts to transform the provision of primary care services at a large multi- specialty practice in Northern California. Role: Co-Investigator

MRSGT-05-194-01-CPHPS (Dohan) 7/1/05-3/31/11 American Cancer Society Clinical Trials Enrollment and Health Disparities This career development award (Rena Pasick, mentor) uses comparative ethnography to examine the organizational factors that lead to under-enrollment of disadvantaged cancer patients in clinical trials. Role: Principal Investigator

No Number (Dohan) 4/1/06-6/30/08 Measuring Quality in a Community-based Oncology Practice: A Pilot Study Foundation for Integrative Oncology This pilot project uses qualitative (ethnographic) and quantitative (medical records) data to examine how quality is understood in community-based oncology practice as well as to explore approaches for implementing quality-improvement in oncology care. Role: Principal Investigator

R21-AA14855 (Dohan) 9/15/03-8/31/07 Poverty, Substance Use, and Stigma in Four Organizations. NIH National Institute for Alcohol Abuse and Alcoholism This project examines how different healthcare organizations, including emergency departments and cancer clinics, shape the stigma experiences of patients who are poor or have substance use problems. Qualitative research methods are used to document how patients manage stigma, to examine how these management strategies are affected by stigma processes in healthcare organizations, and to develop new theory. Role: Principal Investigator

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NAME POSITION TITLE Dow, William H. Professor of Health Economics eRA COMMONS USER NAME willdow EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Cornell University, Ithaca, NY B.A. 1991 Economics Yale University, New Haven, CT Ph.D 1995 Economics RAND, Santa Monica, CA Postdoc 1995-97 Aging

A. Personal statement William H. Dow is Henry J. Kaiser Professor of Health Economics and Associate Dean for Research at the UC-Berkeley School of Public Health, where he teaches Master’s and PhD health economics courses. In addition he is Director of the NIA-funded P30 UC-Berkeley Center on the Economics and Demography of Aging, and Dow has also served since 2005 as the founding Associate Director of the Berkeley Population Center. He is also a Research Associate at the National Bureau of Economic Research, and previously served as Senior Economist at the White House Council of Economic Advisers. Dow’s research analyzes economic aspects of health behaviors, and health and demographic outcomes. Recent work as PI has included a randomized trial of behavioral economics approaches to increasing HIV screening in San Francisco, and a randomized trial analyzing the effect of conditional cash transers on risky sexual behaviors and STI outcomes. Honors include the John D. Thompson Prize for Young Investigators awarded by the Association of University Programs in Health Administration, and the Kenneth J. Arrow Award given by the International Health Economics Association.

B. Positions and Honors

Positions and Employment

1998 Fulbright Scholar, University of Costa Rica 1998-2004 Assistant Professor, Department of Health Policy and Administration, School of Public Health, University of North Carolina at Chapel Hill 2002-present Research Associate, National Bureau of Economic Research 2005-2006 Senior Economist, Council of Economic Advisers, The White House 2004-2010 Associate Professor, Division of Health Policy and Management, School of Public Health, University of California at Berkeley 2010- Professor, Division of Health Policy and Management, School of Public Health, University of California at Berkeley 2014- Associate Dean for Research, School of Public Health, University of California at Berkeley

Other Experience and Professional Memberships

1989-1990 Visiting Scholar, Cambridge University, Cambridge, England 1995 Consultant, Inter-American Development Bank, Mexico City, Mexico 1997-2000 Consultant, RAND, Santa Monica, CA

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Program Director/Principal Investigator (Last, First, Middle): DOW, William H.

2000- NIH grant review panel member on over 10 special emphasis panels 2005- Associate Director, Berkeley Population Center 2006-2012 Director of Berkeley PhD program in Health Services and Policy Analysis 2006-9 MacArthur Network on Socio-Economic Status and Health member 2008-2010 Consultant: World Bank (2008); Kaiser Division of Research (2008-2010) 2009-2013 John Muir Health System: Physician Network Board of Directors 2012- Head, Division of Health Policy and Management, UC-Berkeley School of Public Health 2009-2013 Associate Director, UC-Berkeley Center on the Economics and Demography of Aging 2013- Director, UC-Berkeley Center on the Economics and Demography of Aging

Honors

1991 Summa Cum Laude and Phi Beta Kappa, Cornell University 2000 8th Annual Arrow Award (given by the International Health Economics Association for the best health economics paper published worldwide in 1999) 2001 John D. Thompson Prize for Young Investigators, awarded by the Association of University Programs in Health Administration 2008- Appointed to Henry J. Kaiser Endowed Chair at UC-Berkeley

C. Selected peer-reviewed publications 1. Dow, W. and T. Philipson, “An Empirical Examination of the Implications of Assortative Matching on the Incidence of HIV,” Journal of Health Economics, 15(6), 1996.

2. Philipson, T. and W. Dow, “Infectious Disease Transmission and Infection Dependent Matching.” Mathematical Biosciences 148(2):161-80, 1998.

3. Dow, W., “Flexible Discrete Choice Demand Models Consistent with Utility Maximization: An Application to Health Care Demand.” American Journal of Agricultural Economics 81(3):680-85, 1999.

4. Dow, W., T. Philipson, and X. Sala-i-Martin, “Longevity Complementarities under Competing Risks.” American Economic Review 89(5):1358-1371, 1999.

5. Dow, W. and D. Harris, “Exclusion of International Medical Graduates from Federal Health Care Programs.” Medical Care 40(1):68-72, 2002.

6. Anderson, W., E. Norton, and W. Dow, “Medicare Maximization by State Medicaid Programs: Effects on Medicare Home Care Utilization.” Medical Care Research and Review, 60(2):201-222, 2003.

7. Shin, E., W. Dow, A. Kaluzny, Y. Park, and K. Park, “Disease Coding Errors by Health Care Organizations: Effects of a Government Quality Intervention.” International Journal of Health Planning and Management, 18:151-159, 2003.

8. Dow, W. and E. Norton, “Choosing Between and Interpreting the Heckit and Two-Part Models for Corner Solutions.” Health Services and Outcomes Research Methodology, 4(1):5-18, 2003.

9. Dow, W. and K. Schmeer, “Health Insurance and Child Mortality in Costa Rica.” Social Science and Medicine 57(6):975-986, 2003.

10. Li, Y., E. Norton, and W. Dow, “Influenza and Pneumococcal Vaccination Demand Responses to Changes in Infectious Disease Mortality.” Health Services Research, 39(4):905-926, 2004.

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Program Director/Principal Investigator (Last, First, Middle): DOW, William H.

11. Lee, S-Y, W. Dow, V. Wang, and J. VanGeest, “Use of Deceptive Tactics in Physician Practices: Are There Differences Between International and U.S. Medical Graduates?” Health Policy, 67(3):257-264, 2004.

12. Akin, J.S., W. Dow, and P. Lance, “Did the Distribution of Health Insurance in China Continue to Grow Less Equitable in the Nineties? Results from a Longitudinal Survey.” Social Science and Medicine, 58:293-304, 2004.

13. Lance, P., J. Akin, W. Dow, and C. Loh, “Is Cigarette Smoking in Poorer Nations Highly Sensitive to Price? Evidence From Russia and China.” Journal of Health Economics, 23(1):173-189, 2004.

14. Liu, Z., W. Dow, and E. Norton, “Effect of Drive-Through Delivery Laws on Postpartum Length of Stay and Hospital Charges.” Journal of Health Economics, 23(1):129-155, 2004.

15. Liu, G., W. Dow, A. Fu, and J. Akin, “Health Human Capital and Economic Returns: Evidence From Income Growth In China.” China Economic Quarterly, 4(1):101-116, 2005.

16. Rosero-Bixby, L., W. Dow, and A. Lacle, “Insurance and Other Determinants of Elderly Longevity in a Costa Rican Panel.” Journal of Biosocial Science, 37(6):705-720, 2005.

17. Akin, J., W. Dow, P. Lance, and C. Loh, “Changes in Access to Health Care in China 1989-1997.” Health Policy and Planning, 20(2):80-89, 2005.

18. Xie, J. and W. Dow, “Longitudinal Study of Child Immunization Determinants in China.” Social Science and Medicine, 61(3):601-611, 2005.

19. Bian, J., W. Dow, and D. Matchar, “Medicare HMO Penetration and Mortality Outcomes of Ischemic Stroke.” American Journal of Managed Care, 12(1):58-64, 2006.

20. Price, M., S. Stewart, W. Miller, F. Behets, W. Dow, F. Martinson, D. Chilongozi, M. Cohen, “The cost- effectiveness of treating male trichomoniasis to avert HIV transmission in men seeking STD care in Malawi.” Journal of AIDS, 43(2):202-209, 2006.

21. Dow, W., D. Harris, and Z. Liu, “Differential Effectiveness in Patient Protection Laws: What Are the Causes? An Example from the Drive-Through Delivery Laws.” Journal of Health Politics, Policy and Law, 31(6):1107-1127, 2006.

22. Baicker, K., W. Dow, and J. Wolfson, “Health Savings Accounts: Implications for Health Spending”. National Tax Journal, 59(3):463-475, 2006.

23. Fu A., W. Dow, and G. Liu “Propensity Score and Difference-in-Difference Methods: A Study of Second- Generation Antidepressant Use in Patients with Bipolar Disorder.” Health Services and Outcomes Research Methodology, 7(1-2): 23-38, 2007.

24. Rajan, S., G. Pink ,and W. Dow, “Sociodemographic and Personality Characteristics of Canadian Donors Contributing to International Charity.” Nonprofit and Voluntary Sector Quarterly, 38(3):413-440, 2009.

25. Baicker, K., W. Dow, and J. Wolfson, “Lowering the Barriers to Consumer-Directed Health Care: Responding to Concerns.” Health Affairs, 26(5):1328-1332, 2007.

26. Liu, G., W. Dow, A. Fu, J. Akin, and P. Lance, “Income Productivity in China: on the role of health.” Journal of Health Economics, 27(1):27–44, 2008.

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27. Norton, E., W. Dow, and Y. Do, “Specification tests for the sample selection and two-part models.” Health Services and Outcomes Research Methodology, 8(4):201-208, 2008.

28. Hsu, J., J. Huang, V. Fung, M. Price, R. Brand, R. Hui, B. Fireman, W. Dow, J. Bertko, and J. Newhouse, “Distributing $800 Billion: An Early Assessment of the Medicare Part D Risk Adjustment Approach.” Health Affairs, 28(1):215-225, 2009.

29. Rosero-Bixby, L. and W. Dow, “Surprising SES gradients in mortality, health, and biomarkers in a Latin American population of adults.” Journal of Gerontology: Social Sciences, 64B(1):105-117, 2009.

30. Baicker, K., and W. Dow, “Risk Selection and Risk Adjustment: Improving Insurance in the Individual and Small Group Markets.” Inquiry, 46:215-228, 2009.

31. Rehkopf, D., W. Dow, and L. Rosero-Bixby, “Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the United States (NHANES).” Journal of Epidemiology and Community Health, 64(9):821-8, 2010.

32. Gersten, O., W. Dow, and L. Rosero-Bixby, “Stressors over the life course and neuroendocrine system dysregulation in Costa Rica.” Journal of Aging and Health, 22(6):748-771, 2010.

33. Kawachi I., N. Adler, and W. Dow, “Money, Schooling, and Health: Causal Evidence and Mechanisms.” In N. Adler and J. Stewart (eds.) Biology of Disadvantage. Annals of the New York Academy of Sciences, 1186:56-68, 2010.

34. Dow, W. and D. Rehkopf, “Socioeconomic gradients in health in international and historical context.” In N. Adler and J. Stewart (eds.) Biology of Disadvantage. Annals of the New York Academy of Sciences 1186:24-36, 2010.

35. Dow, W., R. Schoeni, N. Adler, and J. Stewart, “Evaluating the Evidence Base: Policies and Interventions to Address SES Gradients in Health.” In N. Adler and J. Stewart (eds.) Biology of Disadvantage. Annals of the New York Academy of Sciences, 1186:240-251, 2010.

36. Dow, W., B. Fulton, and K. Baicker, “Reinsurance for High Health Costs: Benefits, Limitations, and Alternatives.” Forum for Health Economics & Policy, 13(2), 2010.

37. Hsu, J., V. Fung, J. Huang, M. Price, R. Brand, R. Hui, B. Fireman, W. Dow, J. Bertko, J. Newhouse , "Fixing Flaws In Medicare Drug Coverage That Prompt Insurers To Avoid Low-Income Patients." Health Affairs, 29(12), 2010.

38. Colla, C., W. Dow, and A. Dube, “How do Employers React to a Pay-or-Play Mandate? Early Evidence from San Francisco.” Forum for Health Economics & Policy, 14(2) article 4, 2011. (Prior version as NBER working paper 16179, 2010.)

39. Schoeni, R., W. Dow, W. Miller, and E. Pamuk, “The Economic Value of Improving the Health of Disadvantaged Americans.” American Journal of Preventive Medicine, 40(1S1):S67-S72, 2011. (Prior version published as Technical Report for Overcoming Obstacles to Health: Report from the Robert Wood Johnson Foundation to the Commission to Build a Healthier America, 2008.)

40. Fulton, B., and W. Dow, “Is California Different? State-Specific Risk Adjustment Needs under Health Reform.” California Journal of Politics & Policy, 3(1), 2011.

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41. Modrek, S., W. Dow, and L. Rosero-Bixby, “Long-Term Association of Economic Inequality and Mortality in Adult Costa Ricans.” Social Science & Medicine, 74:158-166, 2012.

42. de Walque, Damien, William H. Dow, Rose Nathan, Ramadhani Abdul, Faraji Abilahi, Erick Gong, Zachary Isdahl, Julian Jamison, Boniphace Jullu, Suneeta Krishnan, Albert Majura, Edward Miguel, Jeanne Moncada, Sally Mtenga , Mathew Alexander Mwanyangala, Laura Packel, Julius Schachter, Kizito Shirima, and Carol A. Medlin, “Incentivising safe sex: a randomized trial of conditional cash transfers for HIV and sexually transmitted infection prevention in rural Tanzania.” BMJ Open 2012;2:e000747. doi:10.1136/bmjopen-2011-000747, 2012. [Extensive international media coverage including Financial Times, BBC, AFP, etc.]

43. Rosero-Bixby, L., and W. Dow, “Predicting mortality with biomarkers: a population-based prospective cohort study for elderly Costa Ricans.” Population Health Metrics, 10:11, 2012.

44. Graetz, I., M. Reed, V. Fung, W. Dow, J. Newhouse, and J. Hsu. “COBRA ARRA Subsidies: Was the Carrot Enticing Enough?” Health Services Research, 47(5):1980-1988, 2012.

45. Packel, L., A. Keller, W. Dow, D. de Walque, R. Nathan, S. Mtenga. “Evolving Strategies, Opportunistic Implementation: HIV Risk Reduction in Tanzania in the Context of an Incentive-Based HIV Prevention Intervention.” PLoS ONE, 7(8): e44058. doi:10.1371/journal.pone.0044058, 2012.

46. Krishnan, S., D. Vohra, D. de Walque, C. Medlin, R. Nathan, and W. Dow. “Tanzanian Couples’ Perspectives on Gender Equity, Relationship Power, and Intimate Partner Violence: Findings from the RESPECT Study.” AIDS Research and Treatment, vol. 2012, Article ID 187890, 9 pages. doi:10.1155/2012/187890, 2012.

47. Fulton, B., O. Galarraga, and W. Dow, “Informing Public Policy Toward Binational Health Insurance: Empirical Evidence from California.” Salud Publica de Mexico, 55(4):S468-S476, 2013.

48. Colla, C., W. Dow, and A. Dube, “San Francisco’s ‘Pay or Play’ Employer Mandate Expanded Private Coverage By Local Firms and A Public Care Program.” Health Affairs, 32(1):69-77, 2013.

49. Fung, V., M. Price, A. Busch, M. Landrum, B. Fireman, A. Nierenberg, W. Dow, R. Hui, R. Frank, J. Newhouse, and J. Hsu. “Adverse Clinical Events Among Medicare Beneficiaries Using Antipsychotic Drugs: Linking Health Insurance Benefits and Clinical Needs.” Medical Care, 51(7):614-21, 2013.

50. Fung, V., M. Reed, M. Price, R. Brand, W. Dow, J. Newhouse, and J. Hsu. “Responses to Medicare Drug Costs Among Near-Poor versus Subsidized Beneficiaries.” Health Services Research, 48(5):1653-68, 2013.

51. White, J., W. Dow, and S. Rungruanghiranya. “Commitment Contracts and Team Incentives for Smoking Cessation: A Randomized Controlled Trial in Thailand.” American Journal of Preventive Medicine, 45(5):533-42, 2013.

52. Rehkopf, D., W. Dow, L. Rosero-Bixby, J. Lin, E. Epel, and E. Blackburn. “Longer Leukocyte Telomere Length in Costa Rica’s Nicoyan Peninsula: A Population-Based Study.” Experimental Gerontology, 48(11):1266-1273, 2013. [Featured in Nature (news section), September 3, 2013.]

53. Rosero-Bixby, L., W. Dow, and D. Rehkopf. “The Nicoya Region of Costa Rica: A High Longevity Island for Elderly Males.” Forthcoming, Vienna Yearbook of Population Research, Volume 11, 2013.

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle): DOW, William H.

54. Minnis, A., E. vanDommelen-Gonzalez, E. Luecke, W. Dow, S. Bautista-Arredondo, and N. Padian. “Yo Puedo - a conditional cash transfer and life skills intervention to promote adolescent sexual health: results of a randomized feasibility study in San Francisco.” Forthcoming, Journal of Adolescent Health.

55. Rehkopf, D, W. Dow, L Rosero-Bixby, J. Lin, E. Epel, E. Blackburn. “Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: a population based observational study.” Forthcoming, American Journal of Human Biology.

56. Domino, M., W. Dow, and F. Coto. “Educational gradients in psychotropic medication use among older adults: A Costa Rica – U.S. comparison.” Forthcoming, Psychiatric Services.

57. Jones-Smith J, W. Dow, K. Chichlowska. “Association between casino opening or expansion and risk of childhood overweight and obesity.” Forthcoming, JAMA.

58. Colla, C., W. Dow, A. Dube, and V. Lovell. “Early Responses to San Francisco’s Paid Sick Leave Policy.” Forthcoming, American Journal of Public Health.

D. Research Support

Ongoing research projects

“Center on the Economics and Demography of Aging (CEDA)” (2009-2014) Role: PI and Director Agency: NIA 5P30AG012839-20 Center grant to promote UC-Berkeley research on the economics and demography of aging via a pilot grant mechanism, workshop support, and computer core.

“Berkeley Population Center” (2014-2018) Role: Associate Director (PI: Goldstein) Agency: NICHD 1R24HD073964-01A1 Funding for infrastructure support for UC-Berkeley’s campus-wide population center.

“Costa Rican Health and Retirement Survey” (2008-2014) Role: PI Agency: NIH R01 AG031716 Field a nationally representative survey of Costa Rican adults born 1945-1955, including baseline wave with extensive biomarkers, a two-year longitudinal follow-up, and long-term mortality tracking.

“Smoking Cessation Contracts with Social and Monetary Incentives” (2013-2017) Role: PI Agency: NIDA 1R01DA03584 Project fields randomized behavioral economics trial to test novel smoking cessation interventions.

“Neighborhood Effects on Weight Change and Diabetes Risk Factors.” (2009-2014) Role: Co-Investigator Agency: NIDDK R01 Project creates a longitudinal database of neighborhood characteristics to assess causal effects of neighborhood food environment on metabolic markers of risk among diabetics at Kaiser.

“Variability of Mortality Levels and Trends by State in the United States” (2011-16) Role: PI (since 2014)

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle): DOW, William H.

Agency: NIA 1R01AG040245 National Institute on Aging Project adds state-level data to the Human Mortality Database.

“Studies in Global Mortality” (2011-15) Role: PI (since 2014) Agency: NIA R01AG11552 Project extends the Human Mortality Database to additional years and countries.

Recently Completed Research Support

“HIV Screening Take-up: Evaluating Incentives and Opt-out Strategies.” (2010-2013) Role: PI Agency: NIH 1RC4AG039078-01 This project fields a behavioral economics experiment to test opt-out and incentive-based strategies for increasing disease screening rates.

“Long-Term Care Economic Insight Report” (2011-2012) Role: PI Agency: Brown Miller Communications for CA Department of Health Care Services Projects California’s long-term care needs and informal caregiving burdens.

“Yo Puedo: Future Opportunities for Youth.” (2010-2012) Role: Consultant Agency: NICHD R21 Formative project to pilot randomized conditional cash transfers intervention to reduce unintended pregnancy among Latina youth in San Francisco.

“Employer-Level Effects of an Employer Health Spending Mandate” (2008-11) Role: PI Agencies: Robert Wood Johnson Foundation, UC California Program on Access to Care and UC Labor Employment Research Fund. Project fields a Bay Area Employer Health Benefits Survey to analyze the impact of San Francisco’s employer health spending ordinance (a “pay-or-play” mandate to increase health insurance coverage).

“The earned income tax credit and child obesity: modifying effects of food prices and neighborhood context.” (2009-11) Role: Co-investigator Agency: Robert Wood Johnson Foundation Examine earned income tax credit effects on child obesity.

“Using Conditional Cash Transfers in HIV/STI Prevention” (2008-2011) Role: PI Agency: Hewlett Foundation, with supplemental funding from NBER Africa Project and World Bank A randomized intervention trial to test the impact of cash incentives in reducing STI transmission in Tanzania.

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Dworkin, Shari Professor and Associate Dean, Academic Affairs eRA COMMONS USER NAME (credential, e.g., agency login) SHARID EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Pennsylvania State University, University Park BS 1990 Honors, Business University of Maryland, College Park MA 1994 Sociology University of Southern California, Los Angeles Ph.D. 2000 Sociology and Gender Studies Columbia University, New York MS 2005 Biostatistics

A. Personal Statement Shari Dworkin, PhD, MS is a Professor in the Department of Social and Behavioral Sciences and Associate Dean of Academic Affairs in the UCSF School of Nursing. I am Affiliated Faculty at the Center for AIDS Prevention Studies and in the Global Health Sciences program. I am the Deputy Co-Director of the UC Global Health Institute Center of Expertise on Women’s Empowerment and Health and I mentor the next generation of scientists to rigorously measure empowerment processes to understand how these influence HIV and violence outcomes. I am trained in sociology, biostatistics, qualitative methods and public health, and my work focuses largely on structural interventions for HIV prevention, treatment, and care. Specifically, my research has an emphasis on structural drivers of HIV/AIDS as these intersect with gender relations, focused on the need for economic empowerment (microfinance, land, and property rights) in HIV programming. I focus not only on the structural needs of women but also of men. Over the past 4 years, in Nyanza and Western Province, Kenya (where the proposed study will be carried out), I have been leading a collaboration (with the Kenyan Medical Research Institute-KEMRI and GROOTS Kenya) to examine the intersection of property rights, violence, and HIV/AIDS prevention within a local land and property program. I am also currently leading a collaborative study (along with the University of Cape Town and Sonke Gender Justice, a South Africa NGO) in four provinces of South Africa to examine the impact of a gender transformative HIV and anti-violence program on men’s violence and risk behaviors. Over the past several years, I have been Co-Investigator on Dr. Weiser and Dr. Cohen’s NIMH R34, SHAMBA MAISHA, an integrated agricultural and microfinance intervention with HIV positive farmers in Western Kenya. I provide expertise in microfinance, in qualitative methods, and provide expertise on the measurement of individual and household levels of empowerment. Domestically, I am Co-PI on an NIMH R01 seeking to measure relationship power among African-American and mixed race gay male couples in San Francisco and New York—and in this project with Colleen Hoff (PI), I am examining the relationship between masculinity, power and HIV risk.

B. Positions and Honors Work Experience 2000-02 Visiting Assistant Professor, Pitzer College, Dept of Sociology, Claremont, CA 2002-05 Post-doctoral Research Fellow, HIV Center for Clinical and Behavioral Studies, Columbia University and NYPSI 2005-08 Assistant Professor, Behavioral Medicine Div. Dept of Psychiatry, Columbia University 2007-2008 Associate Director, NIMH T32 Postdoctoral Training Program in HIV Infection, Columbia University 2006 Junior Faculty Manuscript Award, HIV Center for Clinical and Behavioral Studies, NYSPI and Columbia University 2005-2008 Research Scientist, HIV Center for Clinical and Behavioral Studies, Columbia University and NYPSI

PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 2007-08 Associate Director of Postdoctoral Training in HIV Infection, NIMH T-32, Columbia University and NYSPI 2008-Now Affiliated Faculty Member, Center for AIDS Prevention Studies, University of California, San Francisco 2008-Now Associate Professor, Dept of Social and Behavioral Sciences, UCSF 2008-Now Director, Sociology Doctoral Program, Dept of Social and Behavioral Sciences, UCSF Present Vice Chair, Department of Social and Behavioral Sciences, UCSF Present Affiliated Faculty, Global Health Sciences MS Degree Program, UCSF Present Associate Editor, Archives of Sexual Behavior

Honors 2002 National Research Service Award, National Institute of Health, Columbia University, HIV Center For Clinical and Behavioral Studies 2004 Honorable Mention, Book Award (North American Society for Sociology of Sport). 2006 Junior Faculty Manuscript Award, HIV Center for Clinical and Behavioral Studies, Columbia University and NYPS 2010 Distinguished Scholarship Award, North American Society for the Sociology of Sport 2012 School of Nursing-Research Mentor Award 2012 UCSF Distinction in Mentoring Award

C. Selected peer-reviewed publications 2007 Dworkin, S. Ehrhardt, A.A. Going beyond ABC to Include GEM (Gender Relations, Economic Contexts, and Migration Movements): Critical Reflections on Progress in the HIV/AIDS Epidemic. American Journal of Public Health, 97: 13-16. 2007 Dworkin, S. L. Beckford, S.T., Ehrhardt, A. A Longitudinal Analysis of Sexual Scripts for Women Who Participated in a Gender-Specific HIV/STD Prevention Intervention. Archives of Sexual Behavior, 36: 269-279. 2007 Sawires, S., Dworkin, S.L., Peacock, D., Fiamma, A., Szekeres, G., Coates, T. Male Circumcision and HIV/AIDS: Challenges and Opportunities. Lancet, 369: 708-713. 2007 Coates, T., Fiamma, A., Szekeres, G., Dworkin, S., Remien, B., Hanson, B. W., Rudatsikira, J.B. (2007). Business' role in exercising leadership, promoting equity, embracing accountability, and developing partnerships: HIV/AIDS In Southern Africa. J AIDS, 21, S1-S7. 2008 Dworkin, S.L., Pinto, R., Hunt, J, Rabkin, B., Remien, R. Keeping the Spirit of Community Partnerships Alive in the Scale Up of HIV/AIDS Prevention: Critical Reflections on the Roll Out of DEBI (Diffusion of Effective Behavioral Interventions. American Journal of Community Psychology. 42, 51-59. 2009 Dworkin, S.L., Fullilove, R. Peacock, D. Are HIV/AIDS Prevention Interventions for Heterosexually- Active Men Gender-Specific? A Critical Look at Work in the United States. American Journal of Public Health, 99, 98- 984. 2009 Dworkin, S.L. & Blankenship, K. Microfinance and HIV/AIDS Prevention: Assessing Its Promise and Limitations. AIDS & Behavior, 13, 462-469. 2009 Dworkin, S.L., Gambou, S., Sutherland, C., Moalla, K., Kapoor, A. Gendered “Empowerment” and HIV/AIDS Prevention: Policy and Programmatic Pathways to Success the MENA Region. JAIDS. 51, S111-S118. 2009 Campbell, A., Tross, S., Dworkin, S.L. et al. Relationship Power and Sexual Risk in Community- Based Substance Abuse Treatment. Journal of Urban Health, 86, 951-964. 2010 Higgins, J., Hoffman, S., Dworkin. S.L. Rethinking Gender, Heterosexual Men, and "Women's Vulnerability:" Time to Shift the Paradigm? American Journal of Public Health, 100, 435-445. 2010 Dworkin, S.L. Masculinity, Health, and Human Rights: A Sociocultural Framework. Hastings International Law and Comparative Review, 33, 461-478. 2011 Dworkin, S.L., Dunbar, M., Krishnan, S., Hatcher, A., Sawires, S. Uncovering tensions and capitalizing on synergies in HIV/AIDS and anti-violence programs. American Journal of Public Health, 101, 995- 1003.

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): 2012 Dworkin, S.L., Colvin, C., Hatcher, A., Peacock, D. Men’s perceptions of women’s rights and changing gender relations in South Africa: Lessons for working with men and boys n HIV and anti-violence programs. Gender & Society. 26, 97-120. 2012 Hatcher, A., Tsai, A., Kumbakumba, E. Dworkin, S.L., Hunt, P., Martin, J.M., Clark, G., Bangsberg, D., Weiser, S. Sexual relationship power and depression among HIV-infected women in rural Uganda. PLoS Medicine. 7, 1-12. doi:10.1371/journal.pone.0049821 2013 Lotfi, R., Tehrani, F.R., Khoei, E., Yaghmaei, F., Dworkin, S.L. How do women at risk of HIV/AIDS in Tehran, Iran perceive gender norms and gendered power relations in the context of safer sex negotiations? Archives of Sexual Behavior. 42, 873-881. 2013 Dworkin, S.L., Hatcher, A. Colvin,C., Peacock, D. Impact of an anti-violence and HIV program on masculinities and gender ideologies in Limpopo and the Eastern Cape. Men and Masculinities, 16, 181-202. 2013 Lu, T., Kwena, Z., Zwicker, L., Bukusi, E., Maura-Muira, E., Dworkin, S. Securing women’s property rights in the era of HIV/AIDS: Barriers and facilitators of implementing a community-led structural intervention in Western Kenya. AIDS Education and Prevention, 25, 151-163. 2013 Van den Berg, W., Godana, P., Hendricks, L., Hatcher, A., Dworkin, S.L. (2013). Shifts in fatherhood beliefs and parenting practices following a gender-transformative health programme in Eastern Cape, South Africa. Gender & Development, 21, 111-125 2013 Dworkin, S.L., Treves-Kagan, S., & Lippman, A. Are gender-transformative interventions to reduce violence and HIV/AIDS risks with heterosexually-active men successful? A review of the global evidence. AIDS & Behavior, 17, 2845-2863. 2014 Dworkin, S.L., Grabe, S. Lu, T., Kwena, Z., Bukusi, E. Mwaura-Muira, E. (2013). Property rights violations as a structural driver of women's HIV risks in Nyanza and Western Provinces, Kenya. Archives of Sexual Behavior, 42, 703-715. 2014 Dworkin, S.L., Lu, T., Hatcher, A., Grabe, S., Kwena, Z., Mwaura-Muira, E. & Bukusi, E. (2014). What community-level strategies are needed to secure women's property rights in Western Kenya? Laying the groundwork for a future structural HIV prevention intervention? AIDS CARE, 26, 754-757. 2014 Hatcher, A., Colvin C., Ndlovo, N. & Dworkin, S.L. Intimate partner violence among rural South African men: Alcohol use, sexual decision making and partner communication. Culture, Health, and Sexuality. 2014 Fleming, P, Lee, J. & Dworkin, S.L. (2014). 'Real Men Don't': Constructions of Masculinity and Inadvertent Harm in Gender-Transformative Health Programming. American Journal of Public Health, 104, 1029-1035. In Press Hilliard, S., Bukusi, E., Grabe, S., Lu, T., Hatcher, A., Kwena, Z. Mwaura-Muira, E., & Dworkin, S.L. How does a community-led property rights program impact violence against women? A qualitative analysis from Western and Nyanza Provinces, Kenya. Violence Against Women.

D. Research Support Ongoing Research Support 1R01MH089276 (Hoff,Dworkin) 06/21/10 -05/30/15 NIH/NIMH Role: Co-PI Power and Risk Among Gay Couples This study seeks to examine relationship power among gay male couples who are African-American and mixed race. By examining power differentials among gay male couples, we will be able to understand how power supports or hinders couples in their efforts to prevent HIV transmission and acquisition.

R34 MH094215 (Cohen) 8/30/2011-7/31/2014 NIH/NIMH Role: Co-Investigator Shamba Maisha The objective of the study is to test the hypothesis that a multisectoral agricultural intervention leads to improved health among families living with HIV in Kenya.

No number assigned 1/1/13- 7/31/14 PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Pangea Global AIDS Foundation Role: Consultant The objective of this contract is to produce a systematic literature review on the impact of economic empowerment and self-help groups on measures of women’s empowerment

No Number Assigned (Meffert) 1/1/2013-12/31/2014 CFAR Role: Co-Investigator Gender Based Violence and HIV: Assessing Mental Health Care Needs The objective of this study is to identify mental health and ARV adherence characteristics, determine the need for depression and PTSD care and empowerment factors that may influence the ability to obtain mental health treatment among HIV+GBV+ women in Nyanza Province, Kenya.

Completed Research Support No Number Assigned 11/01/10-10/31/2012 CommonHealth Action/CDC (Dworkin) Role: Senior Research Scientist Economic Intervention Development Project: Addressing the Social and Economic Determinants of HIV/AIDS The goal of this project is to develop a sustainable and adaptable economic intervention for low income African-Americans in the United States. The intervention is being developed for integration into health centers in the United States and will be evaluated for its impact on violence and HIV risks.

NO Number Assigned (Dworkin) 10/01/2009-9/30/2010 CFAR Laying the groundwork to test a science based gender transformative HIV/AIDS prevention intervention with heterosexually active men in South Africa The study will help to further an understanding of masculinity, gender relations, and health in South Africa and will help to improve the quality of HIV prevention programs at Sonke and their efficacy with heterosexually- active men,

No Number Assigned (Dworkin) 6/01/10/-11/30/11 UCSF RAP Property Rights and HIV Prevention: Examining the Impact of a Community Land and Property Watchdog Model in Nyanza and Western Provinces, Kenya This study seeks to fill a gap in knowledge around intersection between HIV/AIDS and property rights by examining the GROOTS WatchDog model in two Kenya’s highest province districts: Rachuonyo District, Nyanza Province and Kakemega District, Western Province.

No Number Assigned (Camlin) 7/31/2009-7/30/2010 CFAR Role: Co-Investigator Sex Differences in Patterns of Migration and HIV Risk in Western Kenya This study will lay the groundwork for a collaboration between UCSF and Kenyan organizations for a subsequent, larger mixed-methods study to assess the contribution of female migration to the HIV/AIDS epidemic in western Kenya, and inform development of an economic HIV prevention intervention with female migrants.

5U62PS924511-05 (Cohen) 04/01/09-06/30/10 CDC Integration of HIV Care and Treatment into MCH in Migori District, Kenya The study seeks to determine the most effective way to reach and provide pregnant women with accessible comprehensive and high quality HIV care and treatment.

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Wayne T.A. Enanoria Assistant Professor eRA COMMONS USER NAME WENANORIA EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Berkeley, CA B.A. 12/94 Molec. and Cell Biology University of California, Berkeley, CA M.P.H 05/97 Epidemiol./Biostatistics University of California, Berkeley, CA Ph.D. 12/03 Epidemiology

A. Personal Statement

I bring my education and professional experience in epidemiology and biostatistics to the PhD Program in Global Health Sciences. I am currently Assistant Professor in the Department of Epidemiology & Biostatistics at the University of California, San Francisco. I have research experience in HIV/AIDS, cryptosporidiosis and other waterborne infectious diseases, pneumococcal vaccine effectiveness among HIV-infected individuals, influenza, measles, and public health preparedness and emergency response. I have served as Project Director and Lead Investigator on several research studies in addition to my professional experience working in local and state public health agencies and the San Francisco Veteran Affairs Medical Center. I was Project Director for a randomized controlled trial of a hand hygiene and respiratory etiquette intervention to reduce the occurrence of inﬂuenza-like illness among university students. I was the Lead Investigator of a CDC-funded study that examined local and state health departments' epidemiology and surveillance response to pandemic influenza A (H1N1) in 2009-2010, as well as issues of surge capacity and mutual aid for infectious disease emergency situations. I am also the Lead Investigator of a UCSF Models of Infectious Disease Agent Study that examines the effectiveness of different components of measles control among a highly vaccinated population. In addition, I am co-instructor of a biostatistics course in the Masters Program in Global Health Sciences at UC San Francisco and Assistant Course Director of a statistical computing course in the Training in Clinical Research Program.

B. Positions and Honors

1994 – 1995 Research Assistant, Division of Tuberculosis Control, San Francisco Department of Public Health 1996 Research Associate, Reproductive Epidemiology Section, California Department of Health Services 1996 Graduate Student Instructor, Introduction to Advanced Epidemiologic Methods, PH250A, School of Public Health, University of California, Berkeley 1997 Researcher, Northern California Institute of Research and Education, San Francisco Veterans Affairs Medical Center 1998 Graduate Student Instructor, Introduction to Advanced Epidemiologic Methods, PH 250A, School of Public Health, University of California, Berkeley 1998-1999 Graduate Student Researcher, Water Environment Research Foundation, University of California, Berkeley 1997-1999 Graduate Student Researcher, Office of AIDS, California Department of Health Services 2000 Statistician, Viral Hepatitis Research, San Francisco Veterans Affairs Medical Center 2000-2003 Communicable Disease Epidemiologist, Community Health Epidemiology and Disease Control, San Francisco Department of Public Health 2006-2008 Project Director, REDucing Influenza-like Illness among University Students (REDI-US) Study 2003-2010 Director, Epidemiology Preparedness and Informatics Program, Center for Infectious Diseases and Emergency Readiness, School of Public Health, University of California, Berkeley 2006-2012 Lecturer, Division of Epidemiology, School of Public Health, University of California at Berkeley 2009-2012 Lead Investigator, Epidemiology Networks (EpiNet) in Action Study 2011-present Lead Investigator, UCSF MIDAS measles study 2011-present Instructor, Masters Program in Global Health Sciences, University of California at San Francisco 2012-2014 Research Epidemiologist, Francis I. Proctor Foundation International, University of California at San Francisco 2014-present Assistant Professor, Department of Epidemiology & Biostatistics, University of California at San Francisco

C. Selected peer-reviewed publications

1. Hubbard A., van der Laan M., Enanoria W., and Colford J. Nonparametric survival estimation when death is reported with delay. Lifetime Data Analysis 2000 Sep, 6(3):237-50. PMID: 10949861. 2. Klausner JD, Aragon T, Enanoria WTA, Mann JK et al. Shigella sonnei outbreak among men who have sex with men – San Francisco, California, 2000-2001. MMWR Morbidity and Mortality Weekly Report 2001 Oct 26;50(42):922-6. PMID: 11699845. Reprinted in JAMA 2002 Jan 2;287(1):37-38. PMID: 11797625. 3. Aragon TJ, Novotny S, Enanoria W, Vugia DJ, Khalakdina A, Katz MH. Endemic cryptosporidiosis and exposure to municipal tap water in persons with acquired immunodeficiency syndrome (AIDS): A case- control study. BMC Public Health 2003;3:2. PMID: 12515584. 4. Pai M, McCulloch M, Enanoria W, Colford JM. Systematic reviews of diagnostic test evaluations: what’s behind the scenes? ACP Journal Club 2004 Jul-Aug;141(1):A11. PMID: 15230574. Reprinted in Evidence- Based Medicine 2004;9(4):101-103. 5. Pai M, McCulloch M, Gorman JD, Pai N, Enanoria W, Kennedy G, Tharyan P, Colford, JM. Systematic reviews and meta-analyses: an illustrated, step-by-step guide. National Medical Journal of India 2004 Mar- Apr;17(2):86-95. PMID: 15141602. 6. Enanoria WTA, Ng C, Saha S, Colford Jr. JM. Treatment outcomes after highly active antiretroviral therapy: a meta-analysis of randomised controlled trials. The Lancet Infectious Diseases 2004 Jul;4(7):414-25. PMID: 15219552. 7. Fewtrell L, Kaufmann RB, Kay D, Enanoria W, Haller L, Colford JM Jr. Water, sanitation and hygiene interventions to reduce diarrhoea in less developed countries: a systematic review and meta-analysis. The Lancet Infectious Diseases 2005 Jan;5(1):42-52. PMID: 15620560. 8. Enanoria WTA, Hubbard AE, van der Laan MJ, Chen Mi, Ruiz J, Colford Jr. JM. Early prediction of median survival among a large AIDS Surveillance Cohort. BMC Public Health 2007; 7:127. PMID: 17597532. PMCID: PMC1925077 9. Veras MASM, Enanoria W, Castilho EA, Reingold AL. Effectiveness of the polysaccharide pneumococcal vaccine among HIV-infected persons in Brazil: a case control study. BMC Infectious Diseases 2007 Oct 23;7(1):119. PMID: 17956620. PMCID: PMC2148048 10. Aiello AE, Coulborn RM, Aragon TJ, Baker MG, Burrus BB, Cowling BJ, Duncan A, Enanoria W, Fabian MP, Ferng Y, Larson EL, Leung GM, Markel H, K. Milton DK, Monto AS, Morse SS, J. Navarro JA, Park SY, Priest P, Stebbins S, Stern AM, Uddin M, Wetterhall SF, Vukotich CJ. Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research. Am J Infect Control 2010 May;38(4):251-8. Epub 2010 Mar 12. PMID: 20226569. 11. Vukotich CJ Jr, Coulborn RM, Aragon TJ, Baker MG, Burrus BB, Aiello AE, Cowling BJ, Duncan A, Enanoria W, et al. Findings, gaps, and future direction for research in nonpharmaceutical interventions for pandemic influenza [conference summary]. Emerg Infect Dis 2010 Apr;16(4):e2. PMID: 20350370. 12. Porco TC, Gao D, Scott JC, Shim E, Enanoria WT, Galvani AP, Lietman TM. When does overuse of antibiotics become a tragedy of the commons? PLoS One 2012;7(12):e46505. PMID: 23236344. PMCID: PMC3517551 13. Enanoria WT, Crawley AW, Tseng W, Furnish J, Balido J, Aragon TJ. The epidemiology and surveillance response to pandemic influenza A (H1N1) among local health departments in the San Francisco Bay Area. BMC Public Health 2013 Mar 27;13(1):276. PMID: 23530722. 14. Homayounfar G, Nardone N, Borkar DS, Tham VM, Porco TC, Enanoria WT, Parker JV, Vinoya AC, Uchida A, Acharya NR. Incidence of scleritis and episcleritis: results from the Pacific Ocular Inflammation Group. Am J Ophthalmol 2013 Oct;156(4):752-8. PMID: 23891336. 15. Liu F, Enanoria WTA, Ray KJ, Coffee MP, Gordon A, Aragon TJ, Cowling BJ, Porco TC. Effect of the one- child policy on influenza transmission in China: a stochastic transmission model. PLoS One. 2014 Feb 6;9(2):e84961. PMID: 24516519. 16. Lowry EA, Lui R, Enanoria W, Keenan J, de Alba Campomanes AG. Repeat Retinomax Screening Changes Positive Predictive Value. J AAPOS 2014 Feb;18(1):45-9. PMID: 24568982. 17. O’Brien K, Blumberg S, Enanoria W, Ackley S, Sippl-Swezey N, Lietman TM. Antibiotic use as a tragedy of the commons: a cross-sectional survey. Computational and Mathematical Methods in Medicine 2014;2014:837929. doi: 10.1155/2014/837929. Epub 2014 Jan 22. PMID: 24587818. 18. Ray KJ, Zhou Z, Chin S, Cevallos V, Enanoria WTA, Liu F, Lietman TM, Porco TC. Estimating community prevalence of ocular Chlamydia trachomatis infection using pooled PCR testing. Ophthalmic Epidemiology 2014 Apr;21(2):86-91. PMID: 24621121. 19. Blumberg S, Enanoria WTA, Lloyd-Smith JO, Lietman TM, Porco TC. Identifying postelimination trends for the introduction and transmissibility of measles in the United States. Am J Epidemiol 2014 Jun 1;179(11):1375-82. PMID: 24786800. 20. Sippl-Swezey N, Enanoria WT, Porco TC. Conflicts of interest during contact investigations: a game- theoretic analysis. Computational and Mathematical Methods in Medicine 2014;2014:952381. PMID: 24982688. 21. Rathinam SR, Babu M, Thundikandy R, Kanakath A, Nardone N, Esterberg E, Lee SM, Enanoria WT, Porco TC, Browne EN, Weinrib R, Acharya NR. Ophthalmology. 2014 Jun 7. pii: S0161-6420(14)00377-7. PMID: 24917273. 22. Enanoria WTA, Crawley AW, Hunter JC, Balido JY, Aragon TJ. The Epidemiology and Surveillance Workforce Among Local Health Departments in California: Mutual Aid and Surge Capacity for Routine and Emergency Infectious Disease Situations. In press, Public Health Reports.

D. Research Support

Ongoing Research Support

Research Grant: 1U01GM087728-01A1 (PI: Travis C. Porco) 08/01/11-07/31/16 Source: National Institute of General Medical Sciences Title: Modeling Contact Investigation and Rapid Response Role: Lead Investigator, The Epidemiology of Imported Measles in California

Completed Research Support

Research Grant: U90/CCU924248 (PI: Tomas Aragon) 09/30/06-09/29/08 Source: Centers for Disease Control and Prevention (CDC) Title: Reducing Influenza-like Illness in University Students (REDI-US) Study Summary: Randomized controlled trial to evaluate effectiveness of non-pharmaceutical interventions in reducing influenza-like illness and influenza. Role: Project Director

Research Grant: P01TP000295 (PI: Tomas Aragon) 09/30/09-12/31/12 Source: Centers for Disease Control and Prevention (CDC) Title: Cal PREPARE: Public Health Systems Research using Emergency Preparedness And Response Events is a CDC Preparedness & Emergency Response Research Center (PERRC) Summary: A study of the epidemiologic and surveillance response to infectious disease emergencies and workforce capacity among local health departments in California and the state department of health in Hawaii. Role: Lead Investigator, Epidemiology Networks in Action Study

Professor Sir Richard Feachem KBE, CBE, BSc, PhD, DSc(Med), FREng, HonFFPHM, HonDEng

Professor Sir Richard G A Feachem is Director of the Global Health Group at UCSF Global Health Sciences, and Professor of Global Health at both the University of California, San Francisco and the University of California, Berkeley. He is also a Visiting Professor at London University and an Honorary Professor at the University of Queensland.

From 2002 to 2007, Sir Richard served as founding Executive Director of the Global Fund to Fight AIDS, Tuberculosis and Malaria and Under Secretary General of the United Nations. During this time, the Global Fund grew from scratch to become the world’s largest health financing institution for developing countries, with assets of US $11 billion, supporting 450 programmes in 136 countries.

From 1999 to 2002, Professor Feachem was the founding Director of the Institute for Global Health at UCSF and UC Berkeley. From 1995 until 1999 Dr. Feachem was Director for Health, Nutrition and Population at the World Bank. Previously (1989-1995), he was Dean of the London School of Hygiene and Tropical Medicine. Professor Feachem served as Chairman of the Foundation Council of the Global Forum for Health Research; Treasurer of the International AIDS Vaccine Initiative; Council Member of Voluntary Service Overseas; and on numerous other boards and committees. He was a member of the Commission on Macroeconomics and Health, and the Commission on HIV and Governance in Africa, and the Commission on Investing in Health. He has worked in international health and development for 40 years and has published extensively on public health, health policy and development finance.

Professor Feachem holds a Doctor of Science degree in Medicine from the University of London, and a PhD in Environmental Health from the University of New South Wales. In 2007 he was awarded an Honorary Doctorate in Engineering by the University of Birmingham. He is a Fellow of the Royal Academy of Engineering and an Honorary Fellow of the Faculty of Public Health Medicine of the Royal College of Physicians and of the American Society of Tropical Medicine and Hygiene. In 2002 he was elected to membership of the Institute of Medicine of the US National Academy of Sciences. Sir Richard was knighted by Her Majesty Queen Elizabeth II in 2007. He was awarded the 2010 Sir Frank Whittle Medal by the Royal Academy of Engineering.

Feb 2014 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Gershon, Robyn R.M. Professor eRA COMMONS USER NAME (credential, e.g., agency login) GERSHONR EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Quinnipiac University BS, MT 05/76 Medical Technology Quinnipiac University MHS 05/81 Medical Microbiology Johns Hopkins University, Bloomberg School of Kellogg 1987-1990 Interdisciplinary Studies in Public Health Fellow Environmental and Occupational Health

Johns Hopkins University, Bloomberg School of DrPH 12/90 Environmental & Public Health Occupational Health Sciences

A. Personal Statement My extensive prior and current research experience in disaster preparedness and response across a wide range of settings, including hospitals, makes me uniquely qualified to participate in the Graduate Group for the PhD in Global Health Sciences. I am an interdisciplinary occupational and environmental health and safety researcher with over 20 years of experience in conducting complex, large scale, multi-method research studies. My work focuses on four major areas: high risk work settings and work occupations and the role of safety climate in occupational risk; worker/patient risk of adverse outcomes and role of safety climate; disaster preparedness and occupational health, and the translation of epidemiological research findings into organizational practices and regulatory control. My research has been continuously funded since 1990, with support from CDC/NIOSH, NIH, AHRQ, NSF, NIJ, DOD, HUD and numerous foundations. In 2002, as PI, I led a large interdisciplinary team on the landmark World Trade Center Evacuation Study, which examined the individual (including psycho-social factors), organizational, and structural factors that affected evacuation time and short and long term morbidity. The results of this study directly resulted in the first changes to the New York City high rise fire safety codes in more than 30 years. In 2009, I conducted and published the first study on disaster preparedness of home health care paraprofessionals and recently wrote a paper entitled “Emergency Preparedness in a Sample of Persons with Disabilities”. Finally, I have over 20 years of direct experience as a mentor to numerous post-baccalaureate, graduate students and junior faculty.

B. Positions and Honors 1980-1983 Associate Director, Department of Biological Safety, Yale University, New Haven, CT. 1980-1987 Program Director, Occupational Health and Safety Training Program, Yale University, New Haven, CT. 1983-1987 Director, Department of Biological Safety, Yale University, New Haven, CT. 1989-1990 Program Coordinator, and Research Associate, Division of Environmental Health Engineering, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 1995-1997 Senior Research Associate, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 1997-1998 Assistant Scientist, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 1998-2000 Associate Scientist, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 2000-2000 Assistant Professor, Mailman School of Public Health, Columbia University, New York, NY. 2001-2006 Associate Professor, Mailman School of Public Health, Columbia University, New York, NY. 2006-2011 Professor, Mailman School of Public Health, Columbia University, New York, NY. 2006-2011 Professor, School of Nursing, Columbia University, New York, NY. 2008-2011 Associate Dean of Research Resources, Mailman School of Public Health, Columbia University, New York, NY 2011-present Professor Emerita, Mailman School of Public Health, Columbia University, New York, NY 2011-present Professor, Department of Epidemiology and Biostatistics and Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California, San Francisco. 2011-present Adjunct Professor, Dept. of Community Health Systems and Division of Occupational and Environmental Health Nursing, School of Nursing, University of California, San Francisco, CA.

Honors and Awards 1987 Kellogg Interdisciplinary Scientist in Environmental and Occupational Health Fellowship 1997 Delta Omega Honorary (Public Health) Society 2004 Fellow, New York Academy of Medicine 2004 Fellow, Society of Healthcare Epidemiology 2005 Davis Lectureship, University of Chicago 2005 Annual International Sharps Injury Prevention Award 2006 Survivors’ Salute, WTC Survivors’ Network 2007 City of New York Fire Commissioner’s Special Commendation Certificate of Appreciation 2010 Renfield Lectureship, Visiting Nurse Service of New York, New York, NY 2012 Invited Speaker: Center for Occupational and Environmental Health, Lela Morris Annual Symposium, Oakland, CA. 2013 Colloquium Lectureship, Pennsylvania State University, Healthcare Management & StrategY Department of Health Policy & Administration, State College, PA 2014 Keynote Speaker, British Columbia Funeral Association Conference, Victoria, BC, Canada

Professional Activities (current) 2011-present Member, Chancellor’s Council on Faculty Life - UCSF 2011-present Chair, Faculty Development Committee - UCSF 2009-present Senior Mentor, Emerging Scholars Interdisciplinary Network 2011-present Member, Institutional Biosafety Committee - UCSF 2011-present Member, Mentoring Committee - UCSF 2013-present Member, Chancellor’s Committee on the Status of Women, UCSF -present Member, 18 Professorial Organizations, including APHA, AAAS, NFPA, APA, etc. -present Editorial Boards: American Journal of Disaster Medicine, Journal of Emergency and Disaster Medicine, Injury Epidemiology

C. Selected Peer-reviewed Publications and book chapters (Selected from over 100 publications) *mentees or advisees 1. Nandi A, Galea S, Tracey M, Ahern J, Resnick H, Gershon RRM, Vlahov D. The effects of job loss, unemployment, work stress, and work satisfaction on the persistence of probable PTSD: Results from a cohort study of New York City metropolitan area residents one year after the September 11 attacks. Journal of Occupational and Environmental Medicine 46(10):1057-1064, 2004. PMID:15602180 2. Goldenhar LM, Gershon RR, Mueller C, Karkashian C, Swanson NA. Psychosocial work stress in female funeral service practitioners. Equal Opportunity International Journal 20(1):17-38, 2001. (no PMID). 3. Gershon RRM, Rubin MS*, Qureshi KA*, Canton AN*, Matzner FJ. Participatory Action Research Methodology in Disaster Research: Results From the World Trade Center Evacuation Study. Disaster Medicine and Public Health Preparedness, 2(3): 142-149, 2008. PMID:18845929 4. Sherman MF, Gershon RRM, Samar SM*, Pearson JM*, Canton AN, Damsky MR. Safety Factors Predictive of Job Satisfaction and Job Retention Among Home Healthcare Aides, Journal of Occupational and Environmental Medicine, 50(12):1430-1441, 2008. PMID: 19092499. 5. Canton AN*, Sherman MF, Magda, LA*, Westra LJ*, Pearson JM*, Raveis VH, Gershon RRM. Violence, Job Satisfaction, and Employment-Related Intentions among Home Healthcare Registered Nurses. Home Healthcare Nurse, 27(6): 2-11, 2009. PMID: 19509522. 6. Neitzel R*, Gershon RRM, Zeltser M*, Canton A, Akram M. Noise Levels Associated with Urban Mass Transit Systems. American Journal of Public Health, 2009, 99(8); 1393-1399. PMID: 19542046 7. Gershon RRM, Vandelinde N*, Magda LA*, Pearson JM*, Werner C, Prezant D. An evaluation of a pandemic preparedness program for emergency medical services personnel. Prehospital and Disaster Medicine, 2009;24(6):488-491. PMID:20301068 8. Gershon RRM, Magda LA*, Riley HEM*, Sherman MR. The World Trade Center Evacuation study: factors associated with initiation and length of time for evacuation. Fire and Materials, February 2011. doi:10.1002/fam.1080. (no PMID). 9. Magda LA*, Canton AN*, Gershon RRM. Web-based weapons of mass destruction training for transit police. Journal of Public Transportation. 2010; 13(3) 63-77. (No PMID) 10. Gershon RRM, Magda LA*, Riley HEM*, Merrill JA. Mass Fatality Preparedness in the Death Care Sector. Journal of Occupational and Environmental Medicine. 2011; 53(10) 1179-1186. PMID:21915068 11. Gershon RR, Dailey M*, Magda LA*, Riley HEM*, Conolly J, Silver A. Safety in the home healthcare sector: Development of a new household safety checklist. Journal of Patient Safety, 2012; 8(2) 51-9. PMID:22543362 12. Gershon RR, Sherman MF, Magda LA, Riley HE, McAlexander TP, Neitzel R. Mass Transit Ridership and Self-Reported Hearing Health in an Urban Population. Journal of Urban Health, 2013 April; 90(2):262-75. PMID: 22711170. 13. Gershon RR, Kraus L, Raveis V, Sherman M, Kailes J. Emergency Preparedness in a Sample of Persons with Disabilities. American Journal of Disaster Medicine. 2013 Winter;8(1):35-47. PMID: 23716372.

D. Research Support Current Funding R01 National Institute of Health General Medical Sciences Gershon (PI) 07/01/13-06/30/17 Biomedical Research Career Identification in Graduate Education (BRIDGE) This four-year project is to determine the effectiveness of a theory-driven, multi-modal intervention designed to increase self-efficacy, outcome expectations, scientific identity, and persistence in pursuing a science research career among underrepresented minority (URM) and non-URM early stage doctoral students.

R21 National Institutes of Nursing Research (NINR) Gershon (PI) 08/01/13-07/31/15 The Role of Social and Behavioral Factors on Disaster Planning in Home Care The goal of this 2-year project is to explore the expectations about emergency preparedness of elderly adults in two high risk cities: New York City and San Francisco; and compare their expectations to the actual capacity of home care agencies and local emergency response agencies. The information obtained from this study can impact preparedness at multiple levels in home care, and can also have an impact at the national levels of emergency planning and response.

National Science Foundation (NSF) Gershon (PI) 10/01/12-09/30/14 Systems-Level Mass Fatality Preparedness The major goals of this project are to identify the preparedness and response capabilities of the mass fatality management infrastructure, and in particular, the offices of the medical examiners/coroners, state and local health departments, state and local offices of emergency management, DMORT teams, the faith-based community, and the death care sector (e.g., the funeral industry and associated services) in the United States. The sector’s ability to manage mass fatalities caused by earthquakes, terrorism, pandemics, and other catastrophic incidents in a prompt and dignified way is a concern to stakeholders within the sector, and externally, with their response partners and the general public.

Recently Completed Research Support (Selected) Association of Schools of Public Health/Centers for Disease Control and Prevention Gershon (PI) 10/01/2002-09/30/2007 The World Trade Center Evacuation Study The study was designed to identify the individual, organizational, and structural factors associated with the evacuation of the World Trade Center Towers One and Two on September 11, 2001. A 3-year, 5-phase, multidisciplinary collaborative study was organized to examine the independent and joint effects of the organizational factors (e.g., drills, evacuation procedures), individual factors (e.g., knowledge, beliefs, attitudes, influence of subjective norm, prior experiences, demographic, and health status factors), and structural factors (such as environmental cues to action, lighting, communication systems) on evacuation behaviors. Participatory action research (PAR) teams comprised of evacuees, researchers, and advisors developed a set of recommendations for improvement in high rise evacuation. This study resulted in multiple publications. Program Director/Principal Investigator (Last, First, Middle): Haan, Glymour, Hiatt

NAME POSITION TITLE Glymour, M Maria Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) Program Director, PhD in Epidemiology & mglymour Translational Science EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Chicago, The College A.B. 06/96 Biology Harvard School of Public Health, Department of S.M. 06/00 Social Epidemiology Health and Social Behavior Harvard School of Public Health, Department of S.D. 06/04 Social Epidemiology Society, Human Development, and Health Harvard School of Public Health, Department of 06/05 Post-doctoral fellow Society, Human Development, and Health Post-doctoral fellow Columbia University, Department of (Robert Wood Johnson Epidemiology, Institute for Social and Economic 06/08 Foundation Health and Research and Policy Society Scholar)

A. Personal Statement I am a social epidemiologist with a focus on chronic conditions, health inequalities, and healthy aging. I have a strong research track record, with both federal and foundation funding for my research, and well over 100 publications in peer-reviewed journals, invited editorials or commentaries, and book chapters. My research focuses on stroke, dementia, and healthy aging, with a strong emphasis on research methods to support causal inference from observational data.

I serve as program director for the PhD in Epidemiology and Translational Science and see many synergies with a PhD program in global health. I have established a clear and successful track record of mentoring. My mentees at every level (masters students, pre-doctoral trainees, and post-doctoral fellows) have fared very well both while working directly with me and afterwards. As shown in the tables section, students and post-docs who have worked with me finish with strong publication and funding records, and find appropriate subsequent employment (appropriate to their level). In recognition of my commitment to students, in 2012 (while an assistant professor at the Harvard School of Public Health), I was awarded the school-wide mentoring award. While at Harvard, I served as the associate director of the Harvard site for the Robert Wood Johnson Health and Society Scholars program.

B. Positions and Honors Positions and Employment 2005-2007 Instructor, Department of Society, Human Development, and Health, Harvard School of Public Health 2007-2013 Assistant Professor, Department of Society, Human Development, and Health, Harvard School of Public Health 2013-present Associate Professor, Department of Epidemiology and Biostatistics, University of California at San Francisco

Honors 2012 Harvard School of Public Health Mentoring Award 2013 Columbia University Psychiatric-Neurological Epidemiology Early Investigator Award, Columbia PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Haan, Glymour, Hiatt

University, Mailman School of Public Health

C. Selected Peer-Reviewed Publications (selected to emphasize publication of mentees, from 98 peer reviewed articles; 20 reviews and commentaries; and 9 book chapters) 1. Glymour MM, Weuve J, Berkman LF, Kawachi I, Robins JM. When is baseline adjustment useful in analyses of change? An example with education and cognitive change. Am J Epidemiol. 2005 Aug 1; 162(3):267-78. PMID: 15987729 2. DeFries TB, Avendano MP, and Glymour MM. Level and change in cognitive test scores predict risk of first stroke. Journal of the American Geriatric Society 2009; 57: 499-505. 3. Glymour MM, Kosheleva A, and Boden-Albala B. Birth and adult residence in the Stroke Belt independently predict stroke mortality. Neurology 2009; 73: 1858-1865. 4. White K, Borrell LN, Wong DW, Galea S, Ogedegbe S, Glymour MM. Racial/ethnic residential segregation and self-reported hypertension among U.S.- and foreign-born blacks in New York City. American Journal of Hypertension 2011; 24: 904-910. 5. Wang Q, Capistrant BD, Ehntholt A, Glymour MM. Long-term rate of change in memory functioning before and after stroke onset. Stroke. 2012 Oct; 43(10):2561-6. PMID: 22935399 6. Capistrant BD, Moon JR, Glymour MM. Spousal caregiving and incident hypertension. Am J Hypertens. 2012 Apr; 25(4):437-43. PMID: 22189941 7. Glymour MM, Tzourio C, Dufouil C. Is cognitive aging predicted by one's own or one's parents' educational level? results from the three-city study. Am J Epidemiol. 2012 Apr 15; 175(8):750-9. PMID: 22472116 8. Capistrant BD, Moon JR, Berkman LF, Glymour MM. Current and long-term spousal caregiving and onset of cardiovascular disease. Journal of Epidemiology and Community Health 2012; 66:951-6. 9. Liu SY, Kawachi I, Glymour MM. Education and inequalities in risk scores for coronary heart disease and body mass index: evidence for a population strategy. Epidemiology. 2012 Sep; 23(5):657-64. PMID: 22814529 10. Glymour MM, Chêne G, Tzourio C, Dufouil C. Brain MRI markers and dropout in a longitudinal study of cognitive aging: the Three-City Dijon Study. Neurology. 2012 Sep 25; 79(13):1340-8. PMID: 22972647 11. Glymour MM, Osypuk TL. Promoting health and improving survival into very old age. BMJ. 2012; 345:e6452. PMID: 23015392 12. Liu SY, Chavan NR, Glymour MM. Type of high-school credentials and older age ADL and IADL limitations: is the GED credential equivalent to a diploma? Gerontologist. 2013 Apr; 53(2):326-33. PMID: 22859434 13. Capistrant BD, Wang Q, Liu SY, Glymour MM. Stroke-Associated Differences in Rates of Activity of Daily Living Loss Emerge Years Before Stroke Onset. J Am Geriatr Soc. 2013 May 13. PMID: 23668393 14. Capistrant BD, Berkman L, Glymour MM. Assessing Mobility Difficulties for Cross-National Comparisons: Results from the WHO Study on Global AGEing and Adult Health.J Am Geriatr Soc.2014, Feb; 62(2): 329- 35 PMID 24438515 15. Rist PM, Capistrant BD, Wu Q, Marden JR, Glymour MM. Dementia and Dependence: Do Modifiable Risk Factors Delay Disability? Neurology. (In press).

D. Research Support On-going Research Support 10SDG2640243 Glymour (PI) 01/01/2010-12/31/2013 American Heart Association vChanges in modifiable risk factors and risk of cardiovascular disease in a national sample of black and white Americans. We will validate self-reported cardiovascular outcomes in the Health and Retirement Study by linking with CMS data, and examine the relationship between changes in major cardiovascular risk factors, in particular depressive symptoms, and onset of cardiovascular disease. Role: PI 1R21 AG034385 Glymour (PI) 04/01/2010-03/31/2014 NIH/NIA vFunctional impairment from stroke: an exploratory study of disparities We use data from the Health and Retirement Study, a national longitudinal study of Americans aged 50 and

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Haan, Glymour, Hiatt older, to study factors that improve people's functioning after stroke. Role: PI W81XWH-12-1-0143 Glymour (PI) 04/20/2012-04/19/2015 US Army Medical Research (USAMRAA) vSocial Resources That Preserve Functional Independence After Memory Loss A large, diverse, longitudinal study of middle aged and older Americans to identify modifiable social factors that help individuals preserve functional independence as long as possible even in the context of declining memory or cognitive impairment. Role: PI R01 AG039588 Howard (PI) 09/01/2011-08/31/2016 NIH/NIA vChildhood SES Factors: impact on age related cognitive and vascular health This project is to incorporate an assessment of early life social conditions into the ongoing REGARDS (REasons for Geographic And Racial Disparities in Stroke) cohort. Collection of new data from cohort members and linkage of previously collected information on residential history at the city/state level to historical information on policies and social conditions prevailing in each place of residence. Role: Co-I (PI of the Subcontract to HSPH) R01 MD 006064 Osypuk (PI) 09/01/2010-08/31/2014 NIH vEffects of a housing policy experiment on youth behavioral problems We analyze data from a social experiment of voluntary neighborhood relocation. My role is to assist with instrumental variable and longitudinal data analyses. Role: Co-I

Completed Research Support R21 HD 066312 Osypuk (PI) 07/01/2010-06/30/2012 NIH/NIHHDvEffects of a neighborhood experiment on adolescent female psychological distress This work examines the Moving To Opportunity housing experiment, using instrumental variables analysis. My role is to assist with implemention of instrumental variable models and longitudinal data analysis. Role: Subcontract PI (with co-investigators on the current proposal Role: Co-I (PI of the subcontract to HSPH) 1R21 AG03788 Subramanian (PI) 09/01/2010-08/31/2012 NIH/NIAvWidowhood and Mortality: Modifying Role of Individual and Community Context Using data from HRS, we will examine whether increased mortality following widowhood is modified by individual, family, or neighborhood factors that provide alternative supportive resources to the surviving spouse. Role: Co-I 1RC4MH092707 Kubzansky (PI) 09/01/2010-08/31/2013 NIH/NIMHvUsing GWAS Data for Enhanced Mendelian Randomization Studies We propose capitalizing on the GWAS data to allow important innovations in MR studies. With data from the Nurses’ Health Study and Health Professionals Follow-up Study, we are using polygenic risk scores as instrumental variables. My role focuses on leading the methods component of this research, including the instrumental variable analyses and validation tests. Role: Co-I

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Eric Goosby, M.D.

NAME POSITION TITLE Goosby, Eric, Paul HS Clinical Instructor eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) AB (Cum Princeton University Princeton, New Jersey 06/74 Biology Laude) Doctor of University of California San Francisco School of Medicine 06/78 Medicine Medicine San Francisco, California (Highest Honors) University of California Clinics and Hospitals Internship 06/79 Internal Medicine University of California Clinics and Hospitals Residency 06/81 Internal Medicine Chief University of California Moffitt 06/81 Primary Care Program Resident Kaiser Family Foundation General UCSF Dept. of Medicine/San Francisco General Research Internal Medicine1 year 06/83 Hospital UCSF Hospitals and Clinics Fellowship course - methodology, epidemiology, statistics ID Clinical year

A. Personal Statement

B. Positions and Honors Positions and Employment 1981-1983 Clinical Instructor, Department of Medicine, University of California, San Francisco San Francisco General Hospital 1983-1991 Assistant Clinical Professor, Department of Medicine; Department of Family and Community Medicine; Department of Nursing (NP Program), University of California, San Francisco 1988-1997 Research Scientist, HIV Treatment Research Unit, Department of Medicine/ Psychiatry/Epidemiology, University of California, San Francisco San Francisco General Hospital 1991-1994 Director (Administrate the distribution of funds and the planning of services for HIV infected people in 52 epicenters in the United States and territories), Division of HIV Services; Ryan White Care Act Title I and II; Bureau of Health Resources Development, U.S. Public Health Service/Health Resources and Services Administration Health Resources Development Administration U.S. Public Health Service 1994-2001 Director of the Office of HIV/AIDS Policy (Responsible for HIV/AIDS policy in the Department of Health and Human Services in the areas of Prevention, Treatment and Research. Full budgetary responsibility; senior interface with Congress with all AIDS-related appropriations; departmental interface with the White House Office of Management and Budget (OMB) and National AIDS Policy Office (served as Deputy Director 2000-2001), Public Health Service Office of Public Health and Science, Office of the Secretary Department of Health and Human Services 1997-1998 Interim Director (Responsible for HIV/AIDS policy across Departments in the Government PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Eric Goosby, M.D.

(Dept of Health and Human Services; Dept of Defense; Veterans Administration; Justice; State; etc).Serve as the principal participant in the White House Domestic Policy Council meetings. Report directly to the President as his senior advisor on HIV related issues. This is a sub-cabinet position reporting directly to the President), National AIDS Policy Office, White House 2000-2001 Deputy Director (Responsible for supporting the Director of National AIDS Policy Office in the White House in all cross-department dealings. Helped conceive of and orchestrate the dialogue for the Minority AIDS Initiative, reauthorization of the Ryan White CARE Act, Needle Exchange and the need for a coordinated response in the global Pandemic of HIV. Represented the NAPO Director and the President in many international meetings for WHO, UNAIDS, USG, NSC, UK and other G8 functions. This job was done concurrent with the Director of HIV/AIDS Policy at DHSS), National AIDS Policy Office, White House 2001-2009 Chief Executive Officer and Chief Medical Officer (The Pangaea Global AIDS Foundation is focused on the development of a continuum of medical and support services for the diagnosis and treatment of sexually transmitted diseases, opportunistic infections associated with HIV, and the safe introduction of anti-retroviral medications to populations in resource poor areas in Sub-Saharan Africa, Eastern Europe, China, SE Asia and India), Pangaea Global AIDS Foundation 2006-2013 Clinical Professor of Medicine (Volunteer Faculty), Department of Medicine, University of California, San Francisco 2009-2013 Ambassador at Large and U.S. Global AIDS Coordinator (Ambassador Eric Goosby serves as the United States Global AIDS Coordinator, leading all U.S. Government international HIV/AIDS efforts. In this role, Ambassador Goosby oversees implementation of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), as well as U.S. Government engagement with the Global Fund to Fight AIDS, Tuberculosis and Malaria), President's Emergency Plan for AIDS Relief (PEPFAR), U. S. Department of State 2012-2013 Special Representative (Ambassador Eric Goosby serves as the head of the Office of Global Health Diplomacy, leading diplomatic efforts to advance the United States' global health mission to improve and save lives and foster sustainability through a shared global responsibility as well as providing diplomatic support in implementing the Global Health Initiative's principles and goals), Office of Global Health Diplomacy, U.S. Department of State

Other Experience and Professional Memberships 1981-present American Board of Medical Specialties Certification: Internal Medicine 1990-present International AIDS Society (IAS)

Honors 1978 Gold Headed Cane Honor Society for Exemplary Clinical Skills, University of California, San Francisco - School of Medicine 1981 H. Kahn Award for Most Admissions in One Night, University of California, San Francisco - Moffitt Hospital (#27) Medical Resident II 1986 Henry J. Kaiser Award for Excellence in Teaching Clinical Medicine (National Award) |Class 1986, University of California, San Francisco - School of Medicine 1991 A.O.A. Medical Honor Society - Induction as Faculty Member, University of California, San Francisco - School of Medicine 1991 Statement of Accomplishments in the Area of AIDS Research in Minority Populations, State Assembly of California Resolution, Assemblyman John Burton 1991 Statement of Accomplishments in the Area of AIDS -, State Assembly of California Resolution, Assemblyman Willie Brown 1991 Resolution of Appreciation for Work in the Minority AIDS Community, City and County of San Francisco, Supervisors Willie Kennedy and Doris Ward 1991 Certificate of Appreciation for Clinical Work with Injection Drug Users, National Black Coalition Against AIDS

PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Eric Goosby, M.D.

1994 Administrator Award for Excellence, Health Resource Service Administration (HRSA) 1994 Award for General Excellence, HRSA Bureau of Health Resources Development 1995 Award for the Conceptualization and Implementation of the Concept of the Continuum of Care for HIV Infected People, Division of HIV Services/HRSA/BHRD 1998 Secretarial Certificate of Acknowledgement for Leadership in the Development of the Standards for the Use of Antiretroviral in Adults, Adolescents, Pregnant Women, Health Workers, and Children, Department of Health and Human Services, Office of the Assistant Secretary of Health 1998 Secretarial Certificate of Acknowledgement for Leadership in the Development of the DHHS Needle Exchange Position, Department of Health and Human Services, Office of the Secretary 1999 Annual Award Presentation, San Francisco AIDS Foundation 2001 Secretarial Award for the Conceptualization and Implementation of the Minority AIDS Initiative, Department of Health and Human Services, Office of the Secretary 2001 Leadership Award for the Minority AIDS Initiative, Black Coalition on AIDS 2001 Legislative Recognition for Reauthorization of the Ryan White Care Act; and Leadership in the Minority AIDS Initiative, Department of Health, State of Illinois 2001 White House Award: Recognition for Work as the Deputy Director, National AIDS Policy Office - William J. Clinton 2001 Heroes in the Struggle Honoree, African American AIDS Policy and Training Institute, Black AIDS Institute, Los Angeles, California 2001 Recognition at Annual Award Dinner, AIDS Health Project, University of California, San Francisco 2004 Hero in Medicine Award, International Assoc. of Physicians in AIDS Care 2007 Community Service Award, 360: The Positive Care Center, University of California, San Francisco 2013 Recognition Award for the President's Emergency Plan for AIDS Relief (PEPFAR) from the President and Ministers of Health, Rwanda, South Africa, Mozambique, Namibia, Botswana, Kenya 2013 Distinguished Service Award from Secretary of State Hillary Rodham Clinton, U.S. Department of State, Washington, D.C. 2014 International AIDS Society (IAS) Presidential Award, International AIDS Society, Melbourne, Australia 2014 Research in Action Award (RIAA), Treatment Action Group (TAG), New York, New York

C. Selected Peer-Reviewed Publications 1. Goosby E, Goldschlager N. Medical management of angina: nitrates, beta blockers, calcium channel blockers. Postgrad Med. 1982 Sep; 72(3):50-2, 55-9, 62-3 passim. PMID: 6126868 2. Cummings SR, Phillips SL, Wheat ME, Black D, Goosby E, Wlodarczyk D, Trafton P, Jergesen H, Winograd CH, Hulley SB. Recovery of function after hip fracture. The role of social supports. J Am Geriatr Soc. 1988 Sep; 36(9):801-6. PMID: 3411063 3. Bowen GS, Marconi K, Kohn S, Bailey DM, Goosby EP, Shorter S, Niemcryk S. First year of AIDS services delivery under Title I of the Ryan White CARE Act. Public Health Rep. 1992 Sep-Oct; 107(5):491- 9. PMID: 1410229. PMCID: PMC1403689 4. McKinney MM, Wieland MK, Bowen GS, Goosby EP, Marconi KM. States' responses to Title II of the Ryan White CARE Act. Public Health Rep. 1993 Jan-Feb; 108(1):4-11. PMID: 8434096. PMCID: PMC1403324 5. Pizzo P, Wilfert C, Goosby E, committee member et al. Antiretroviral therapy and Medical Management of the HIV Infected Child: Ped Infect Dis J. 1993; 12:513-22. 6. Macher A, Goosby E, Barker L, Volberding P, Goldschmidt R, Balano KB, Williams A, Hoenig L, Gould B, Daniels E. Educating primary care providers about HIV disease: multidisciplinary interactive mechanisms. Public Health Rep. 1994 May-Jun; 109(3):305-10. PMID: 8190853. PMCID: PMC1403494 7. Macher A, Goosby E, Daniels E, Plotnick J. Telephone information services from USPHS. Am J Nurs. 1994 Sep; 94(9):12. PMID: 8080014 8. American Medical Association Advisory Group on HIV Early Intervention: Human immunodeficiency virus early intervention physician guidelines, second edition. Archives of Family Medicine. 1994; 3:988-1002. PMID:7804482 9. Sumaya C, Macher A, Bowen S, Goosby E. Educating Health Care Professionals about HIV/AIDS. JAMA 272(16):1242 Oct, 26, 1994. PMID: 7933360 10. Goosby EP. Miles to go before we sleep. Bull N Y Acad Med. 1995; 72(1 Suppl):309-15. PMID: 8535437. PMCID: PMC2359368 PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Eric Goosby, M.D.

11. Macher A, Goosby E, Beller M. PCR and the misdiagnosis of active tuberculosis. N Engl J Med. 1995 Jan 12; 332(2):128-9. PMID: 7990902 12. Macher AM, Goosby EP. Physicians' experience and survival in patients with AIDS. N Engl J Med. 1996 Aug 1; 335(5):350; author reply 350-1. PMID: 8668219 13. Macher AM, Goosby EP. Maintenance of chemoprophylaxis against Pneumocystis carinii despite combination antiretroviral treatment associated CD4+ T-lymphocytosis. Am J Respir Crit Care Med. 1997 Apr; 155(4):1491. PMID: 9105103 14. Macher AM, Goosby EP. Inmate access to postrelease medical care: public health implications. Arch Fam Med. 1997 Jul-Aug; 6(4):318. PMID: 9225700 15. Macher AM, Goosby EP. The diagnostic laboratory as clinical consultant: public health implications. Am J Clin Pathol. 1997 Aug; 108(2):238. PMID: 9260766 16. Macher AM, Goosby EP. Issues regarding antiretroviral treatment for patients with HIV-1 infection. JAMA. 1997 Oct 15; 278(15):1234-5. PMID: 9333261 17. Macher A, Goosby E. Issues regarding antiretroviral treatment for patients with HIV-1 infection. JAMA 278(15) 1234-1235, October 1997.USPHS Panel on Clinical Practices for Treatment of HIV Infection: Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. Morbidity and Mortality Weekly Report. 47(RR-5): 40-82. April 1998. 18. Goosby E, Macher A. Primary HIV Infection/Acute Retroviral Syndrome: An Intervention Opportunity for Correctional Facilities. J Correct Health Care 1998 5(1):51-62. 19. Gordon M, Bihari B, Goosby E, Gorter R, Greco M, Guralnik M, Mimura T, Rudinicki V, Wong R, Kaneko Y. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial. J Med. 1998; 29(5-6):305-30. PMID: 10503166 20. Fauci A, Bartlett JG, Goosby E. Early treatment of HIV-1 infection. Lancet. 1998 Dec 12; 352(9144):1935; author reply 1936. PMID: 9863813 21. UPSPH Panel on Clinical Practices for treatment of HIV infection: Guidelines for the use of antiretroviral agents in HIV-infected adults. Annals of Internal Medicine. 128 (12 Part 2) Supplemental: 1079-1100. June 1998. PMID:9652993 22. Sibel S, Macher A, Goosby E. Paronychia in patients receiving antiretroviral therapy for human immunodeficiency virus infection. J Am Podiatr Med Assoc. 2000 Feb; 90(2):98-100. PMID: 10697975 23. Vlahov D, Des Jarlais DC, Goosby E, Hollinger PC, Lurie PG, Shriver MD, Strathdee SA. Needle exchange programs for the prevention of human immunodeficiency virus infection: epidemiology and policy. Am J Epidemiol. 2001 Dec 15; 154(12 Suppl):S70-7. PMID: 11744532 24. Zhang F, Haberer JE, Wang Y, Zhao Y, Ma Y, Zhao D, Yu L, Goosby EP. The Chinese free antiretroviral treatment program: challenges and responses. AIDS. 2007 Dec; 21 Suppl 8:S143-8. PMID: 18172383 25. Holmes CB, Coggin W, Jamieson D, Mihm H, Granich R, Savio P, Hope M, Ryan C, Moloney-Kitts M, Goosby EP, Dybul M. Use of generic antiretroviral agents and cost savings in PEPFAR treatment programs. JAMA. 2010 Jul 21; 304(3):313-20. PMID: 20639565 26. Holmes CB, Thirumurthy H, Padian NS, Goosby EP. AIDS funds: prevention. Science. 2010 Oct 8; 330(6001):176-7; author reply 177-8. PMID: 20929758 27. Collins FS, Glass RI, Whitescarver J, Wakefield M, Goosby EP. Public health. Developing health workforce capacity in Africa. Science. 2010 Dec 3; 330(6009):1324-5. PMID: 21127233 28. Padian NS, Holmes CB, McCoy SI, Lyerla R, Bouey PD, Goosby EP. Implementation science for the US President's Emergency Plan for AIDS Relief (PEPFAR). J Acquir Immune Defic Syndr. 2011 Mar 1; 56(3):199-203. PMID: 21239991 29. Clay R, CdeBaca L, De Cock KM, Goosby E, Guttmacher A, Jacobs S, Pablos-Mendez A, Polaski S, Sheldon G, Steinberg D. A call for coordinated and evidence-based action to protect children outside of family care. Lancet. 2012 Jan 14; 379(9811):e6-8. PMID: 22166902 30. Holmes CB, Blandford JM, Sangrujee N, Stewart SR, DuBois A, Smith TR, Martin JC, Gavaghan A, Ryan CA, Goosby EP. PEPFAR's past and future efforts to cut costs, improve efficiency, and increase the impact of global HIV programs. Health Aff (Millwood). 2012 Jul; 31(7):1553-60. PMID: 22778345 31. Cohen MS, Holmes C, Padian N, Wolf M, Hirnschall G, Lo YR, Goosby E. HIV treatment as prevention: how scientific discovery occurred and translated rapidly into policy for the global response. Health Aff (Millwood). 2012 Jul; 31(7):1439-49. PMID: 22778333

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32. Goosby E. The President's Emergency Plan for AIDS Relief: marshalling all tools at our disposal toward an AIDS-free generation. Health Aff (Millwood). 2012 Jul; 31(7):1593-8. PMID: 22778350 33. Goosby E. The way forward: maximizing our impact through shared responsibility and smart investments. J Acquir Immune Defic Syndr. 2012 Aug 1; 60 Suppl 2:S44-7. PMID: 22772391 34. Goosby E, Von Zinkernagel D, Holmes C, Haroz D, Walsh T. Raising the bar: PEPFAR and new paradigms for global health. J Acquir Immune Defic Syndr. 2012 Aug 15; 60 Suppl 3:S158-62. PMID: 22797738 35. Goosby E, Dybul M, Fauci AS, Fauci AA, Fu J, Walsh T, Needle R, Bouey P. The United States President's Emergency Plan for AIDS Relief: a story of partnerships and smart investments to turn the tide of the global AIDS pandemic. J Acquir Immune Defic Syndr. 2012 Aug 15; 60 Suppl 3:S51-6. PMID: 22797740 36. Goosby EP. US visa law: a clarification. Lancet Infect Dis. 2012 Nov; 12(11):828. PMID: 23099077 37. Goosby EP. Is Option B+ the best choice? Lancet. 2013 Apr 13; 381(9874):1272. PMID: 23582389 38. Tucker JD, von Zinkernagel DJ, Goosby EP. An inclusive rights-based foreign policy for health. Lancet. 2013 Aug 31; 382(9894):745-6. PMID: 23993176. PMCID: PMC3893702 39. Sidibé M, Goosby EP. Foreword: Global action to reduce HIV stigma and discrimination. J Int AIDS Soc. 2013; 16(3 Suppl 2):18893. PMID: 24242270. PMCID: PMC3833194 40. Binagwaho A, Kyamanywa P, Farmer PE, Nuthulaganti T, Umubyeyi B, Nyemazi JP, Mugeni SD, Asiimwe A, Ndagijimana U, Lamphere McPherson H, Ngirabega Jde D, Sliney A, Uwayezu A, Rusanganwa V, Wagner CM, Nutt CT, Eldon-Edington M, Cancedda C, Magaziner IC, Goosby E. The human resources for health program in Rwanda--new partnership. N Engl J Med. 2013 Nov 21; 369(21):2054-9. PMID: 24256385

D. Research Support

PHS 398/2590 (Rev. 06/09) Page 5 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Hsiang, Michelle, Sang

BIOGRAPHICAL SKETCH NAME Roly Gosling POSITION TITLE eRA COMMONS USER NAME Associate Adjunct Professor EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) University of Nottingham, UK BMedSci 1989-1992 Behavioral Sciences University of Nottingham, UK BM,BS 1989-1994 Medicine and surgery University of London, UK MSc 1997-1998 Infection and Health in the Tropics University of London, UK PhD 2006-2011 Epidemiology

A. Personal Statement

I am currently Associate Adjunct Professor in Epidemiology and Biostatistics and Lead of the Malaria Elimination Initiative at the UCSF Global Health Group. My current research aims to address surveillance, diagnosis and treatment challenges for malaria elimination in low transmission countries in southern Africa and the Asia-Pacific. I am the Co-PI on a major grants from the Bill and Melinda Gates Foundation and PI on a grant from the Novartis Foundation for Sustainable Development. Both grants cover several research studies all focused on malaria elimination and include research on the epidemiology of malaria at low transmission, potential interventions using GIS systems, social networks and quality improvement and clinical trials in drugs that can be used for malaria elimination. I have mentored 18 pre-doctoral students and 2 post-doctoral studenta. My trainees have continued into academic and programmatic positions in global health and several are leading malaria clinical trials. I am a member of the Surveillance, Monitoring and Evaluation Technical Expert Group on malaria for the World Health Organization.

B. Positions and Honors

Positions and Employment 1994-1996 Medical intern, Somerset and Shrewsbury Hospitals UK 1996- 1997 Senior House Officer in emergency medicine and pediatrics, John Radcliffe and Whittington Hospitals, UK 1998-2000 Senior House Officer in pediatrics and neonatology, Royal Free Hospital, UK 2000-2002 Clinical Research Fellow, University College London, UK based in Tanzania 2002-2004 Specialist Training in Medical Microbiology, Royal Free Hospital, UK 2004-2008 Clinical Lecturer, London School of Hygiene and Tropical Medicine, UK based in Tanzania 2008-2010 Specialist Training in Medical Microbiology, Royal Free Hospital, UK 2011-present Associate Adjunct Professor, Malaria Elimination Initiative, Univ. of California, San Francisco.

Other Experience and Professional Membership 1999 -present Member of the Royal College of Pediatrics and Child Health 2010-present Member of the Royal College of Pathologists 2010-present Member, Malaria Elimination Group 2011-present Academic editor, PLoS ONE 2011-present Co-Coordinator, Asia Pacific Malaria Elimination Network Secretariat 2011-present Member, Asia Pacific Malaria Elimination Network, Vivax Working Group 2014- present Member of the Surveillance, Monotioring and Evaluation Technical Expert Group for the World Health Organisation.

Honors 1999 Employee recognition award, Royal Free Hospital.

C. Selected peer-reviewed publications (Selected from 45 peer-reviewed publications)

Most relevant to the current application

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Hsiang, Michelle, Sang 1: Mosha JF, Sturrock HJ, Greenwood B, Sutherland CJ, Gadalla NB, Atwal S, Hemelaar S, Brown JM, Drakeley C, Kibiki G, Bousema T, Chandramohan D, Gosling RD. Hot spot or not: a comparison of spatial statistical methods to predict prospective malaria infections. Malar J. 2014 Feb 11;13(1):53. doi: 10.1186/1475-2875-13-53. PubMed PMID: 24517452; PubMed Central PMCID: PMC3932034.

2: Liu JX, Bousema T, Zelman B, Gesase S, Hashim R, Maxwell C, Chandramohan D, Gosling R. Is Housing Quality Associated with Malaria Incidence among Young Children and Mosquito Vector Numbers? Evidence from Korogwe, Tanzania. PLoS One. 2014 Feb 5;9(2):e87358. doi: 10.1371/journal.pone.0087358. eCollection 2014. PubMed PMID: 24505285; PubMed Central PMCID: PMC3914816.

3: Sturrock HJ, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, Gosling RD. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Med. 2013;10(6):e1001467. doi: 10.1371/journal.pmed.1001467. Epub 2013 Jun 18. PubMed PMID: 23853551; PubMed Central PMCID: PMC3708701.

4: Mosha JF, Sturrock HJ, Greenhouse B, Greenwood B, Sutherland CJ, Gadalla N, Atwal S, Drakeley C, Kibiki G, Bousema T, Chandramohan D, Gosling R. Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics. Malar J. 2013 Jul 1;12:221. doi: 10.1186/1475-2875-12-221. PubMed PMID: 23815811; PubMed Central PMCID: PMC3701503.

5: Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet. 2013 Sep 7;382(9895):900-11. doi: 10.1016/S0140-6736(13)60310-4. Epub 2013 Apr 15. Review. Erratum in: Lancet. 2013 Sep 7;382(9895):858. PubMed PMID: 23594387.

Additional recent publications of importance to the field (in chronological order)

1: Dial NJ, Ceesay SJ, Gosling RD, D'Alessandro U, Baltzell KA. A qualitative study to assess community barriers to malaria mass drug administration trials in The Gambia. Malar J. 2014 Feb 4;13:47. doi: 10.1186/1475-2875-13-47. PubMed PMID: 24495715; PubMed Central PMCID: PMC3915615.

2: Liu Y, Hsiang MS, Zhou H, Wang W, Cao Y, Gosling RD, Cao J, Gao Q. Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001-2011. Malar J. 2014 Jan 25;13:29. doi: 10.1186/1475-2875-13-29. PubMed PMID: 24460982; PubMed Central PMCID: PMC3922785.

3: Sanders KC, Rundi C, Jelip J, Rashman Y, Smith Gueye C, Gosling RD. Eliminating malaria in Malaysia: the role of partnerships between the public and commercial sectors in Sabah. Malar J. 2014 Jan 21;13:24. doi: 10.1186/1475-2875-13-24. PubMed PMID: 24443824; PubMed Central PMCID: PMC3917703.

4: Gosling RD, Hsiang MS. Malaria and severe anemia: thinking beyond Plasmodium falciparum. PLoS Med. 2013 Dec;10(12):e1001576. doi: 10.1371/journal.pmed.1001576. Epub 2013 Dec 17. PubMed PMID: 24358032; PubMed PHS 398/2590 (Rev. 06/09) Page 2 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Hsiang, Michelle, Sang Central PMCID: PMC3866086.

5: Hsiang MS, Hwang J, Tao AR, Liu Y, Bennett A, Shanks GD, Cao J, Kachur SP, Feachem RG, Gosling RD, Gao Q. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malar J. 2013 Nov 1;12:383. doi: 10.1186/1475-2875-12-383. PubMed PMID: 24175930; PubMed Central PMCID: PMC3842644.

6: Smith Gueye C, Sanders KC, Galappaththy GN, Rundi C, Tobgay T, Sovannaroth S, Gao Q, Surya A, Thakur GD, Baquilod M, Lee WJ, Bobogare A, Deniyage SL, Satimai W, Taleo G, Hung NM, Cotter C, Hsiang MS, Vestergaard LS, Gosling RD. Active case detection for malaria elimination: a survey among Asia Pacific countries. Malar J. 2013 Oct 9;12:358. doi: 10.1186/1475-2875-12-358. PubMed PMID: 24103345; PubMed Central PMCID: PMC3852840.

7: Koita K, Novotny J, Kunene S, Zulu Z, Ntshalintshali N, Gandhi M, Gosling R. Targeting imported malaria through social networks: a potential strategy for malaria elimination in Swaziland. Malar J. 2013 Jun 27;12(1):219. doi: 10.1186/1475-2875-12-219. PubMed PMID: 23805843; PubMed Central PMCID: PMC3710236.

8: Smith DL, Cohen JM, Chiyaka C, Johnston G, Gething PW, Gosling R, Buckee CO, Laxminarayan R, Hay SI, Tatem AJ. A sticky situation: the unexpected stability of malaria elimination. Philos Trans R Soc Lond B Biol Sci. 2013 Jun 24;368(1623):20120145. doi: 10.1098/rstb.2012.0145. Print 2013 Aug 5. PubMed PMID: 23798693; PubMed Central PMCID: PMC3720043.

9: Sturrock HJ, Novotny JM, Kunene S, Dlamini S, Zulu Z, Cohen JM, Hsiang MS, Greenhouse B, Gosling RD. Reactive case detection for malaria elimination: real-life experience from an ongoing program in Swaziland. PLoS One. 2013 May 20;8(5):e63830. doi: 10.1371/journal.pone.0063830. Print 2013. PubMed PMID: 23700437; PubMed Central PMCID: PMC3658965.

10: Bauch JA, Gu JJ, Msellem M, M√•rtensson A, Ali AS, Gosling R, Baltzell KA. Perception of malaria risk in a setting of reduced malaria transmission: a qualitative study in Zanzibar. Malar J. 2013 Feb 22;12:75. doi: 10.1186/1475-2875-12-75. PubMed PMID: 23433302; PubMed Central PMCID: PMC3584900.

11: Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C; Primaquine in Africa Discussion Group. Rationale for short course primaquine in Africa to interrupt malaria transmission. Malar J. 2012 Oct 30;11:360. doi: 10.1186/1475-2875-11-360. Review. PubMed PMID: 23130957; PubMed Central PMCID: PMC3502539.

12: Gueye CS, Teng A, Kinyua K, Wafula F, Gosling R, McCoy D. Parasites and vectors carry no passport: how to fund cross-border and regional efforts to achieve malaria elimination. Malar J. 2012 Oct 11;11:344. doi: 10.1186/1475-2875-11-344. PubMed PMID: 23057734; PubMed Central PMCID: PMC3506506.

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Hsiang, Michelle, Sang

13: Modrek S, Liu J, Gosling R, Feachem RG. The economic benefits of malaria elimination: do they include increases in tourism? Malar J. 2012 Jul 28;11:244. doi: 10.1186/1475-2875-11-244. PubMed PMID: 22839351; PubMed Central PMCID: PMC3470964.

C. Research Support.

ONGOING A115501 (Co- PI) 08/01/2010 - 07/31/2015 Bill and Melinda Gates Foundation $2,613,818 direct/yr1 Building the Evidence Base for Malaria $8,165,386 total Elimination A121292 05/01/2013 - 04/30/2014

(PI) Bill and Melinda Gates Foundation $543,262 direct/yr1 Preparation of Background Papers to Inform the $543,262 total Foundation Malaria Strategy 01/01/2014 - 12/31/2016 A122394 (Co-PI) Bill and Melinda Gates Foundation $3,736,567 direct/yr1 Shrinking the Malaria Map: Maintaining $14,035,077 total Progress Towards Malaria Eradication A122666 01/01/2014 - 12/31/2017

(PI) Novartis Foundation for Sustainable $579,677 direct/yr1 Development Eliminating Plasmodium falciparum with ACTs in sub-Saharan Africa

COMPLETED Project Number: OPP 1008337 GCE (Gosling) 10/01/2009-04/30/2011 Source: Gates Grand Challenge for Exploration, Bill and Melinda Gates Foundation Title: Towards eliminating malaria in malaria endemic Africa: Targeting hotspots in rural poorly resourced settings-A Pilot study. Major goals: To define and describe malaria hotspots and determine possible interventions to target them Role: Principal Investigator

Project Number: 28579 (Daniel Chandramohan) Source: Bill and Melinda Gates Foundation 04/01/2004-#/#/2009 Title: Drug options for intermittent preventive treatment for malaria in infants in an area with high resistance to sulfadoxine/pyrimethamine: An evaluation of short and long-acting antimalarial drugs Major goals: To establish the efficacy of both long and short acting drugs for the purpose of IPTi in different transmission settings. Role: Project Leader

Project Number: 38773 (Gosling) 08/01/2006-08/01/2010 Source: Bill and Melinda Gates Foundation Title: Measurement of antimalarial drug resistance in the IPTi Trials Major goals: To assess the relationship between efficacy of IPTi drugs and drug resistance Role: Principal Investigator

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Distinguished Professor, Oral Biology & Oral Pathology, Greenspan, John Associate Dean for Global Oral Health Director of UCSF AIDS Specimen Bank, School of Dentistry; greenspanj Distinguished Professor, Pathology and Director-Emeritus, AIDS Research Institute, School of Medicine. EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) st Royal Free Hospital Medical School, London BSc (1 Honors) 06/1959 Anatomy Royal Dental School, London BDS (Honors) 01/1963 Dentistry Royal Postgraduate Medical School, London PhD 05/1967 Experimental Pathology Royal College of Pathologists, UK MRCPath 06/1971 Oral Pathology Royal College of Pathologists, UK FRCPath 06/1983 Oral Pathology

A. Personal Statement Areas of Expertise. My oral disease research interest centers on the epidemiology, etiopathogenesis and management of oral soft tissue diseases, notably those associated with HIV infection and other causes of immunosuppression, as well as aphthous ulcers, Sjögren's syndrome, and oral cancer/pre-cancer. These topics have led to broad explorations in epidemiology, public/global health, policy, implementation science and other areas. I served until 2005 as founding Director of the UCSF Oral AIDS Center (OAC), which was supported by the NIDCR for 20 years. The OAC continues its research on the pathogenesis of oral lesions associated with HIV infection. I am part of a team looking into the molecular pathogenesis of EBV-associated hairy leukoplakia, a lesion that Deborah Greenspan and I discovered. In conjunction with Dr Caroline Shiboski, I am co-PI of the UCSF site of the international oral AIDS program that is part of the NIAID-funded AIDS Clinical Trails Network (ACTG). In the Oral AIDS/HIV Collaborative Alliance (OHARA), we work with teams at North Carolina and Case examining oral lesions as markers of immunosuppression, treatment initiation and HAART failure in a worldwide network of centers. We also conduct clinical trials of agents and modalities to treat oral opportunistic infections, neoplasms, and autoimmune/idiopathic lesions of HIV infection. I have been the PI of the NIDCR-funded International Research Registry Network for Sjögren’s Syndrome (SICCA) and continue to provide guidance to the PIs of the project. Track record in Mentorship. Students: At the undergraduate, predental/premedical student level I provide advice and support to a number of students, including several of our Undergraduate Mentoring Program students each year.I provide general guidance and mentoring for academic career-oriented dental and DDS/PhD students, through my advisor role to the John C. Greene Society. Fellows: Until 2007 I was the Director/PI of one of only two K12 NIDCR-funded Mentored Dental Clinician Scientist Training Awards nationwide. K12 DE 14609, the Western Oral Research Consortium a five University dental school group intended to identify, support and train future dentist clinician academics. I have been an active mentor in the UCSF Roadmap K12/KL2 Award, now folded into our Clinical and Translational Sciences Institute under the NIH Roadmap CTSA Program. I have been active in selecting awardees. My mentoring in the UCSF/Gladstone Institute of Immunology and Virology Center for AIDS Research Mentoring program includes my mentee 2004-2006 Brinda Emu, Fellow in Infectious disease in the Department of Medicine at SFGH and the GIVI. Faculty: My role as Associate Dean for Research in the School of Dentistry involved, as does my current role of Associate Dean for Global Oral Health, among other responsibilities, the mentoring of a number of junior and senior faculty members. Depending on their level of seniority, this involves many of the mentoring activities I contribute for fellows and K12/KL2 trainees. In my role as Director of the campuswide AIDS Research Institute [ARI], based in the Office of the Dean, School of Medicine, I mentored a significant number of mid-level and fairly senior faculty members, applying the same approaches for them as I did for my mentee faculty colleagues in the SoD. B. Positions and Honors Positions and Employment

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 1963 Fellow, Histochemistry, Royal Postgraduate Medical School, London 1963-1971 Assistant Lecturer, through Senior Lecturer, Oral Pathology, RDH London 1969-1971 Fellow, Pathology, St. George's Hospital Medical School, London 1972-1973 Visiting Associate Professor, Schools of Dentistry and Medicine, UCSF 1971-1976 Senior Lecturer/Consultant Pathologist, Royal Dental Hospital School of Dental Surgery, (RDH) Consultant to St. George's Hospital and Institute of Dermatology, all University of London. 1976-present Professor, Oral Biology and Oral Pathology, School of Dentistry and Pathology, School of Medicine, UCSF 1976-1988 Professor and Chair, Division of Oral Biology, School of Dentistry, UCSF 1982-present Director, UCSF AIDS Specimen Bank 1987-1991 Associate Director, UCSF Dental Clinical Epidemiology Program 1987-2005 Director, UCSF Oral AIDS Center 1988-2001 Professor & Chair, Department of Stomatology, School of Dentistry, UCSF 1993-1999 Director, UCSF AIDS Clinical Research Center (ACRC), School of Medicine, UCSF 1999-2006 Director, UCSF California AIDS Research Center (CARC), School of Medicine, UCSF 2001-2006 Leland A. and Gladys K. Barber Professor of Dentistry 2001-2009 Associate Dean for Research, School of Dentistry, UCSF 2003-2012 Director, AIDS Research Institute at UCSF (ARI) 2009-present Distinguished Professor, Schools of Dentistry and Medicine, UCSF 2010-present Associate Dean for Global Oral Health, School of Dentistry, UCSF Other Experience and Professional Memberships 1979-1981 Chair of Faculty, School of Dentistry, UCSF 1983-1984 President, Experimental Pathology Group, International Association for Dental Research 1981-1985 Vice Chair, Chair, UCSF Division of the Academic Senate of the University of California 1985-present Fellow, American Association for the Advancement of Science 1986-1989 Vice President, President-Elect, President, American Association for Dental Research 1993 Oral Biology Research Award, IADR 1994-1997 Vice President, President-Elect, President, IADR 1995-present Member, Institute of Medicine 2011-present Chair, Global Oral Health Interest Group, Consortium of Universities for Global Health 2013-present President, Global Oral Health Inequalities Network, IADR Honors 1990 Sc. D (hc) Georgetown University 1996-1997 Royal Society of Medicine Foundation/Burroughs Wellcome Visiting Professor, London, UK 1997-present Who’s Who in America 1998-present Fellow in Dental Surgery, Royal College of Surgeons of England 2001-2006 Leland A. and Gladys K. Barber Endowed Chair in Dentistry, UCSF 2003-present Fellow, King’s College London 2006 Mentor Award, National Student Research Group, AADR 2008 Positive Health Practice Award, 360: Positive Care Center at UCSF 2009 John Greene Society Faculty Research Award, UCSF 2010 American Association of Dental Research (AADR) Distinguished Scientist Award 2011 King’s College London Dental Institute Alumnus of the Year Award 2012 American Dental Association Gold Medal for Excellence in Dental Research 2014 UCSF Academic Senate Faculty Research Lwecture Award – Translational Science. C. Selected Peer-reviewed Publications Recent publications of importance (in chronological order)

1. Burbelo PD, Kovacs JA, Wagner J, Bayat A, Rhodes CS, De Souza Y, Greenspan JS, Iadarola MJ. “The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma,” AIDS Research and Treatment, Vol. 2012, Article ID 634523, 10 pages, doi:10.1155/2012/634523, 2012. 2. Baer AN, Gourin CG, Westra WH, Cox DP, Greenspan JS, Daniels TE; Sjögren's International Collaborative Alliance, “Rare diagnosis of IgG4-related systemic disease by lip biopsy in an

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): international Sjogren syndrome registry.” Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115:e34-9. doi: 10.1016/j.oooo. 3. De Souza YG, Greenspan JS. Biobanking past, present and future: responsibilities and benefits. AIDS 2013;27:303-3012. 4. Daniels TE, Cox D, Shiboski CH, Schiødt M, Wu A, Lanfranchi H, Umehara H, Zhao Y, Challacombe S, Lam MY, De Souza Y, Schiødt J, Holm H, PAM, Gandolfo MS, Sawaki T, Li M, Zhang W, Varghese-Jacob B, Ibsen P, Keszler A, Kurose N, Nojima T, Odell E, Criswell LA, Jordan R, and Greenspan JS, “Associations Between Salivary Gland Histopathologic Diagnoses and Phenotypic Features of Sjögren’s Syndrome Among 1,726 Registry Participants”, Arth & Rheum 63(7) 2021–2030, 2011. PMID: 21480190. 5. Shiboski CH, Webster-Cyriaque JY, Ghannoum M, Greenspan JS, Dittmer D, Rodriguez-Chavez, I. "Overview of the Oral HIV/AIDS Research Alliance Program", Adv. Dental Res 23(1):28-33, 2011. 6. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara NA, Greenspan JS, Daniels TE. “A Simplified Quantitative Method for Assessing Keratoconjunctivitis Sicca from the Sjögren’s Syndrome International Registry”, Am J Ophthal 149:405- 415, 2010 PMID 20035924. 7. Shiboski CH, Patton LL, Webster-Cyriaque JY, Greenspan D, Traboulsi RS, Ghannoum M, Jurevic R, Phelan JA, Reznik D, Greenspan JS. "The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints", J Oral Pathol Med, 38: 481-488, 2009, PMID19594839. 8. Navazesh M, Mulligan R, Karim R, Mack WJ, Ram S, Seirawan H, Greenspan JS, Greenspan D, Phelan J, Alves M. “Effect of HAART on Salivary Gland Function in the Women’s Interagency HIV study (WIHS).”, Oral Dis. 15(1):52-60, 2009, PMID 2644059. (Awarded Best Original Article published by Oral Diseases during 2009.) 9. Daniels T, Criswell L, Shiboski C, Shiboski S, Lanfranchi H, Dong Y, Schiødt M, Umehara H, Sugai S, Challacombe S, Greenspan JS. “An Early View of the International Sjögren’s Syndrome Registry”, AR 61:711-714, 2009. PMID 19405009. 10. Tugizov S, Herrera R, Veluppllai P, Greenspan JS, Greenspan D, Palefsky J. “EBV-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium”, J Med Virol 81:5484-5496, 2007, PMID 17376918. 11. Rao UKM, Kannan R, Srivatsan P, Ramachandran H, Rajasekaran ST, Kumarasamy N, Solomon S, Greenspan JS. “Oral lesions among persons with HIV disease with and without highly active antiretroviral therapy (HAART) in southern India” J of Oral Pathol Med 36:136-141, 2007, PMID 17305634. 12. Palefsky JM, Berline J, Penaranda ME, Lennette E, Greenspan D, Greenspan JS. Sequence variation of latent membrane protein 1 of Epstein-Barr virus strains associated with hairy leukoplakia. J Infect Dis 173:710-714, 1996, PMID 8627036. 13. Baumgarth N, Szubin R, Dolganov GS, Watnik M, Greenspan D, Jordan R, Roederer R and Greenspan JS.. Technical Advance: Highly Tissue-Substructure Specific Effects of Human Papilloma Virus in Mucosa of HIV Infected Patients Revealed by Laser Dissection Microscopy-Assisted Gene. Am J Path 165:707-718, 2004, PMID: 15331396. 14. Fleischmann J, Kremmer E, Greenspan JS, Grasser FA, Niedobitek G. Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. J Med Virol. 68(4):568-73, 2002, PMID 12376965. 15. Palefsky JM, Berline J, Greenspan D, Greenspan JS. Evidence for trafficking of Epstein-Barr virus strains between hairy leukoplakia and peripheral blood lymphocytes. J Gen Virol. 83(Pt 2):317-21, 2002, PMID 11807224. D. Ongoing Research Support ACTIVE

HHSN268201300057C (PI: CH Shiboski; co-PI: L Criswell) 9/30/13-9/29/18 NIH/NIDCR International Research Registry Network for Sjögren’s Syndrome

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): The major goal of this contract is to disseminate data and biospecimens collected as part of the International Research Registry Network for Sjören's Syndrome to the scientific community to conduct epidemiologic and genetic studies on Sögren's Syndrome. Role: Co-Investigator P30AI027763 (Volberding) 07/15/02-06/30/13 Center for AIDS Research (CFAR), UCSF AIDS Specimen Bank The purpose of CFAR is to continue the expansion of translational HIV investigations that bridge the disciplines of basic, clinical, and behavioral sciences. Role: Director, CFAR Specimen Bank Core. U01 AI 68636 (Kuritzkes) 6/29/06-12/31/13 Leadership for HIV/AIDS Clinical Trials Group (ACTG), Social and Scientific Systems Project: Oral HIV/AIDS Research Alliance (OHARA) (Shiboski) The goal OHARA is to develop and implement an oral HIV/AIDS research agenda within the ACTG infrastructure. OHARA will provide the capacity to investigate the oral complications associated with HIV/AIDS and to address such overarching questions as the effects of potent antiretrovirals on the development of opportunistic infections (OIs) and the natural history of oral OIs, variation and resistance in the context of immune suppression. Roles: Co-Investigator and Co-PI of the UCSF component. AI34989 (Greenblatt, R.) 01/01/97-12/30/18 NIH/NIAID The Connie Wofsy Women's HIV Study (WIHS) - Specimen Bank This projects' main focus is to study the natural history and pathogenesis of HIV-infection in a large cohort of women at risk for AIDS in the San Francisco Bay Area. Role: Dr. Greenspan is responsible for the biobanking of WIHS specimens. 3P01AT005013 Hecht F. 9/30/2008-5/31/2014 SHINE Obesity is epidemic and is one of our most serious public health problems. Many of obesity's unfavorable health effects are more strongly related to central (abdominal and upper trunk) adiposity than to peripheral adiposity. The results of the study will provide important new information about whether a mind-body intervention targeted to reduce adverse stress reactions and improve awareness of eating behaviors is useful in treating obesity and altering features of the metabolic syndrome. Role: Dr. Greenspan is responsible for the banking of SHINE specimens. COMPLETED 5UL1 RR024131-02 (McCune) 09/30/06-06/30/11 Clinical and Translational Sciences Institute (CTSI), Strategic Opportunities Support (SOS) 1) Enhance, support, and integrate existing training programs, increasing the number and quality of programs and providing trainees with the knowledge, skills, and motivation to make significant contributions to clinical and translational research; 2) Enhance career development of people involved in clinical investigation and translational research by providing mentoring, exploiting opportunities to catalyze original research, and changing the academic culture to appropriately reward original, multidisciplinary, collaborative work; 4) Create a "virtual home" for clinical and translational researchers, thereby nurturing communication, encouraging collaboration, fostering original ideas, and catalyzing the successful conduct of clinical investigation and translational research. Role: Co- Investigator U01 AI 41531 (Levy) 7/1/97-6/30/08 Acute Infection and Early Disease Research Network UCSF AIDS Specimen Bank To form an HIV-1 acute infection and early disease research unit using innovative approaches to recruit and retain at least 25 persons with acute HIV and 40 with early HIV infection for four years. Role: Co-Investigator P01 DE07946 (Greenspan) 11/01/86 – 4/30/07 Oral Manifestations of AIDS This program project proposal is a continuation of our work focusing on the oral manifestations of AIDS. This will enable us to better understand the pathogenesis of oral candidiasis and hairy leukoplakia, and to better define the epidemiology of oral lesions.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Diane V. Havlir Professor of Medicine eRA COMMONS USER NAME (credential, e.g., agency login) DHAVLIR EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) St. Olaf College, Northfield, MN BA 1980 Chemistry/Biology Duke University Medical School, Durham, NC MD 1984 Medicine A. Personal Statement Training the next generation of researchers in HIV and co-infections is a priority in my professional career. I work actively with scientists in training both in San Francisco and Uganda. Areas of focus include antiretroviral therapy strategies and HIV and co-infections (tuberculosis and malaria). For the proposed study, I will work with Dr. Kamya and Uganda faculty to identify opportunities for trainees to conduct implementation science analysis within the context of our ongoing funded studies. B. Positions and Honors Research and Professional Experience 1984–1987 - Internal Medicine Internship and Residency, Univ. of California, San Francisco, CA; 1987–1988 - Attending Physician, Chief of Hospital Based Home Care, Veterans Hosp., San Francisco, CA; 1988–1990 - Infectious Disease Fellowship, University Hospitals, Cleveland, OH; 1990–1996 - Assistant Professor of Medicine, University of California, San Diego, CA; 1990–2002 - Attending Physician, Veteran's Administration Medical Center, San Diego, CA; 1992–2002 - Clinical Director, UCSD Antiviral Research Center (AVRC), San Diego, CA; 1996–2002 - Associate Professor of Medicine, University of California, San Diego, CA; 2002– present - Professor of Medicine, University of California, San Francisco, CA; 2002–present - Chief, HIV/AIDS Division, San Francisco General Hosp., Univ. of California, San Francisco, CA Awards and Service Summa Cum Laude, St. Olaf College; Alpha Omega Alpha, Duke University Medical School; Merck Community Service Award; AIDS and Related Research Study Section, NIAID, NIH; WHO, Steering Committee for Program on Global Monitoring of HIV Drug Resistance; WHO Core Committee for Antiretroviral Treatment Guidelines for Resource Limited Settings; City of San Diego HIV “Spirit of the Quest” Award; International AIDS Society Governing Council; Elected into the American Society of Clinical Investigation; HIV Research Achievement Award of the IDSA and HIVMA; Chair, HIV/TB; Group; Board of Directors, WHO and STOP TB Partnership; Scientific Chair, International AIDS Conference, 2010, Vienna, Austria; Pediatric FLAG Mentorship Award, UCSF; AIDS Research Institute Mentorship Award, UCSF; US Chair International AIDS Conference, 2012, Washington, DC, USA; Joseph E. Smadel IDSA Award, 2012, Pathways Mentorship Award, UCSF, 2014 C. Selected Peer-Reviewed Publications (From 226) 1. Havlir, D.V. & Hammer, S.M. (2005). Patents versus patients? Antiretroviral therapy in India. N Engl J Med, 353(8), 749-751. PMID: 16120852. 2. Huang, L., Quartin, A., Jones, D. & Havlir, D.V. (2006). Intensive care of patients with HIV infection. N Engl J Med, 355(2), 173-181. PMID: 16837681. 3. Havlir, D.V., Getahun, H., Sanne, I. & Nunn, P. (2008). Opportunities and challenges for HIV care in overlapping HIV and TB epidemics. Jama, 300(4), 423-430. PMID: 18647985. 4. Havlir, D.V. (2008). HIV integrase inhibitors--out of the pipeline and into the clinic. N Engl J Med, 359(4), 416-418. PMID: 18650518. 5. Chamie, G., Luetkemeyer, A., Charlebois, E. & Havlir, D.V. (2010). Tuberculosis as part of the natural history of HIV infection in developing countries. Clin Infect Dis, 50 Suppl 3(15), S245-254. PMID: 20397955, NIHMSID: 266764.

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 6. Bebell, L.M., Pilcher, C.D., Dorsey, G., Havlir, D., Kamya, M.R., Busch, M.P., Dunn Williams, J., Nugent, C.T., Bentsen, C., Rosenthal, P.J. & Charlebois, E.D. (2010). Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. Aids, 24(12), 1945-52. PMID: 20543656. 7. Chamie, G., Charlebois, E.D., Srikantiah, P., Walusimbi-Nanteza, M., Mugerwa, R.D., Mayanja, H., Okwera, A., Whalen, C.C. & Havlir, D.V. (2010). Mycobacterium tuberculosis Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4(+)-Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4(+) Cell Count. Clin Infect Dis, 51(3), 359-362. PMID: 20569064. 8. Charlebois, E.D., Ruel, T.D., Gasasira, A.F., Achan, J., Kateera, F., Akello, C., Cao, H., Dorsey, G., Rosenthal, P.J., Ssewanyana, I., Kamya, M.R. & Havlir, D.V. (2010). Short-Term Risk of HIV Disease Progression and Death in Ugandan Children Not Eligible for Antiretroviral Therapy. J Acquir Immune Defic Syndr, 55(3), 330-335. PMID: 20592617, NIHMSID: 221614. 9. Charlebois, E.D. & Havlir, D.V. (2010). "A Bird in the Hand . . . ": A Commentary on the Test and Treat Approach for HIV: Comment on "Comparative Effectiveness of HIV Testing and Treatment in Highly Endemic Regions". Arch Intern Med, 170(15), 1354-1356. PMID: 20696961, NIHMSID: 266758. 10. Chamie, G., Luetkemeyer, A., Walusimbi-Nanteza, M., Okwera, A., Whalen, C.C., Mugerwa, R.D., Havlir, D.V. & Charlebois, E.D. (2010). Significant variation in presentation of pulmonary tuberculosis across a high resolution of CD4 strata. Int J Tuberc Lung Dis, 14(10):1295-1302. PMID: 20843421, NIHMSID: 266762. 11. Charlebois, E.D., Das, M., Porco, T.C. & Havlir, D.V. (2011). The Effect of Expanded Antiretroviral Treatment Strategies on the HIV Epidemic among Men Who Have Sex with Men in San Francisco. Clin Infect Dis, 52(8), 1046-1049. PMID: 21460322. 12. Ruel, T.D., Zanoni, B.C., Ssewanyana, I., Cao, H., Havlir, D.V., Kamya, M., Achan, J., Charlebois, E.D. & Feeney, M.E. (2011). Sex Differences in HIV RNA Level and CD4 Cell Percentage During Childhood. Clin Infect Dis, 53(6), 592-599. PMID: 21840929. PMCID: PMC3160805. 13. Nanteza, M.W., Mayanja-Kizza, H., Charlebois, E., Srikantiah, P., Lin, R., Mupere, E., Mugyenyi, P., Boom, W.H., Mugerwa, R.D., Havlir, D.V. & Whalen, C.C. (2011). A Randomized Trial of Punctuated Antiretroviral Therapy in Ugandan HIV-Seropositive Adults With Pulmonary Tuberculosis and CD4+ T-Cell Counts of >=350 cells/{micro}L. J Infect Dis, 204(6):884-892. PMID: 21849285. PMCID: PMC3156928. 14. Luetkemeyer, A.F., Getahun, H., Chamie, G., Lienhardt, C. & Havlir, D.V. (2011). Tuberculosis Drug Development: Ensuring People Living with HIV are not Left Behind. Am J Respir Crit Care Med, 184(10), 1107-1113. PMID: 21868507. 15. Haubrich, R.H., Riddler, S.A., Ribaudo, H., Dirienzo, A.G., Klingman, K.L., Garren, K.W., Butcher, D.L., Rooney, J.F., Havlir, D.V. & Mellors, J.W. (2011). Initial Viral Decay to Assess the Relative Antiretroviral Potency of PI-, NNRTI- and NRTI-Sparing Regimens for First Line Therapy of HIV Infection. Aids, 25(18), 2269-2278. PMID: 21941167. 16. Geng, E.H., Kahn, J.S., Chang, O.C., Hare, C.B., Christopoulos, K.A., Jones, D., Petersen, M.L., Deeks, S.G., Havlir, D.V. & Gandhi, M. (2011). The Effect of AIDS Clinical Trials Group Protocol 5164 on the Time From Pneumocystis jirovecii Pneumonia Diagnosis to Antiretroviral Initiation in Routine Clinical Practice: A Case Study of Diffusion, Dissemination, and Implementation. Clin Infect Dis, 53(10):1008-1014. PMID: 21960715. PMCID: PMC3193829. 17. Luetkemeyer, A.F., Charlebois, E.D., Hare, C.B., Black, D., Smith, A., Havlir, D.V. & Peters, M.G. (2011). Resistance Patterns and Response to Entecavir Intensification Among HIV-HBV-Coinfected Adults With Persistent HBV Viremia. J Acquir Immune Defic Syndr, 58(3):e96-99. PMID: 22005002. 18. Havlir, D.V., Kendall, M.A., Ive, P., Kumwenda, J., Swindells, S., Qasba, S.S., Luetkemeyer, A.F., Hogg, E., Rooney, J.F., Wu, X., Hosseinipour, M.C., Lalloo, U., Veloso, V.G., Some, F.F., Kumarasamy, N., Padayatchi, N., Santos, B.R., Reid, S., Hakim, J., Mohapi, L., Mugyenyi, P., Sanchez, J., Lama, J.R., Pape, J.W., Sanchez, A., Asmelash, A., Moko, E., Sawe, F., Andersen, J. & Sanne, I. (2011). Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N Engl J Med, 365(16):1482-1491. PMID: 22010914. 19. Ruel, T.D., Boivin, M.J., Boal, H.E., Bangirana, P., Charlebois, E., Havlir, D.V., Rosenthal, P.J., Dorsey, G., Achan, J., Akello, C., Kamya, M.R. & Wong, J.K. (2012). Neurocognitive and Motor Deficits in HIV- Infected Ugandan Children With High CD4 Cell Counts. Clin Infect Dis, 54(7), 1001-1009. PMID: 22308272. 20. Riley, E.D., Neilands, T.B., Moore, K., Cohen, J., Bangsberg, D.R. & Havlir, D. (2012). Social, Structural PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): and Behavioral Determinants of Overall Health Status in a Cohort of Homeless and Unstably Housed HIV- Infected Men. PLoS ONE, 7(4), e35207. PMID: 22558128, PMCID: PMC3338834. 21. Tseng ZH, Secemsky EA, Dowdy D, Vittinghoff E, Moyers B, Wong JK, Havlir DV, Hsue PY. Sudden cardiac death in patients with human immunodeficiency virus infection. J Am Coll Cardiol. May 22 2012;59(21):1891-1896. PMID: 22595409. PMCID: 3356565. 22. Havlir D, Beyrer C. The Beginning of the End of AIDS? N Engl J Med. Jul 18 2012. PMID: 22809362. 23. Thirumurthy H, Chamie G, Jain V, Kabami J, Kwarisiima D, Clark TD, Geng E, Petersen ML, Charlebois ED, Kamya MR, Havlir DV. Improved employment and education outcomes in households of HIV-infected adults with high CD4 counts: evidence from a community health campaign in Uganda. Aids. Nov 19 2012. PMID: 23169332. 24. Tseng ZH, Moyers B, Secemsky EA, Havlir DV, Hsue PY. PR Interval and Sudden Cardiac Death in Patients With HIV Infection. J Infect Dis. Nov 27 2012. PMID: 23186784. 25. Jain V, Liegler T, Kabami J, Chamie G, Clark TD, Black D, Geng EH, Kwarisiima D, Wong JK, Abdel- Mohsen M, Sonawane N, Aweeka FT, Thirumurthy H, Petersen ML, Charlebois ED, Kamya MR, Havlir DV. Assessment of Population-Based HIV RNA Levels in a Rural East African Setting Using a Fingerprick- Based Blood Collection Method. Clin Infect Dis. Dec 12 2012. PMID: 23243180. 26. Cohan D, Mwesigwa J, Natureeba P, Aliba Luwedde F, Ades V, Plenty A, Kakuru A, Achan J, Clark T, Osterbauer B, Kamya M, Havlir D. WHO option B+: early experience of antiretroviral therapy sequencing after cessation of breastfeeding and risk of dermatologic toxicity. J Acquir Immune Defic Syndr. Mar 1 2013;62(3):e101-103. PMID: 23924639. PMC3738916. NIHMS432076. 27. Nosyk B, Audoin B, Beyrer C, Cahn P, Granich R, Havlir D, Katabira E, Lange C, Lima VD, Patterson T, Strathdee S, Williams B, JSG M. Examining the evidence on the causal effect of highly active antiretroviral therapy on transmission of human immunodeficiency virus using the Bradford Hill criteria. Aids. Apr 24 2013;27(7):1159-1165. PMID: 23902921. 28. Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. Oct 18 2013. PMID: 24152939. 29. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+T cells, including myeloid cells. Aids. Dec 6 2013. PMID: 24322272. 30. Chamie G, Kwarisiima D, Clark TD, Kabami J, Jain V, Geng E, Balzer LB, Petersen ML, Thirumurthy H, Charlebois ED, Kamya MR, Havlir DV. Uptake of Community-Based HIV Testing during a Multi-Disease Health Campaign in Rural Uganda. PLoS ONE. 2014;9(1):e84317. PMID: 24392124. PubMedCentralID: 3879307. 31. Kotwani P, Kwarisiima D, Clark TD, Kabami J, Geng EH, Jain V, Chamie G, Petersen ML, Thirumurthy H, Kamya MR, Charlebois ED, Havlir DV. Epidemiology and awareness of hypertension in a rural Ugandan community: a cross-sectional study. BMC Public Health. Dec 9 2013;13(1):1151. PMID: 24321133. 32. Grinsztejn B, Hosseinipour MC, Ribaudo HJ, Swindells S, Eron J, Chen YQ, Wang L, Ou SS, Anderson M, McCauley M, Gamble T, Kumarasamy N, Hakim JG, Kumwenda J, Pilotto JH, Godbole SV, Chariyalertsak S, de Melo MG, Mayer KH, Eshleman SH, Piwowar-Manning E, Makhema J, Mills LA, Panchia R, Sanne I, Gallant J, Hoffman I, Taha TE, Nielsen-Saines K, Celentano D, Essex M, Havlir D, Cohen MS. 2014. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet Infect Dis, PMID: 2460284 33. Ruel T, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal P, Charlebois E, Havlir D, Kamya M, Achan J. Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir-ritonavir or nonnucleoside-reverse-transcriptase-inhibitor therapy. J Acquir Immune Defic Syndr. Dec 8 2013. PMID: 24326597. 34. Chamie G, Kwarisiima D, Clark TD, Kabami J, Jain V, Geng E, Balzer LB, Petersen ML, Thirumurthy H, Charlebois ED, Kamya MR, Havlir DV. Uptake of Community-Based HIV Testing during a Multi-Disease Health Campaign in Rural Uganda. PLoS ONE. 2014;9(1):e84317. PMID: 24392124. PubMedCentralID: 3879307. 35. Young SL, Plenty AH, Luwedde FA, Natamba BK, Natureeba P, Achan J, Mwesigwa J, Ruel TD, Ades V, Osterbauer B, Clark TD, Dorsey G, Charlebois ED, Kamya M, Havlir DV, Cohan DL. 2014. Household Food Insecurity, Maternal Nutritional Status, and Infant Feeding Practices Among HIV-infected Ugandan Women Receiving Combination Antiretroviral Therapy. Matern Child Health J PMID: 24585398 PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 36. Kakuru A, Jane A, Muhindo M, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G. 2014. Artemisinin-based Combination Therapies are Efficacious and Safe for Treatment of Uncomplicated Malaria in HIV-infected Ugandan Children. Clin Infect Dis, PMID: 24759826.

D. Research Support Ongoing Research Support UM1AI069496 12/01/2013 – 11/30/2020 NIH/NIAID San Francisco Bay CTU The major goal of this project is to advance HIV prevention and treatment science forward and being major contributors to the HVTN, HPTN, MTN and ACTG. Role: Co-Principal Investigator

P01 HD059454 (Havlir) 08/01/2008-06/30/2018 NIH-NICHD Novel Strategies to Prevent Malaria and Improve HIV Outcomes in Africa The primary goal will be to build on current knowledge to establish new approaches to reduce HIV and malaria burden in sub-Saharan Africa, and to advance the public health approach to both diseases. Role: Principal Investigator

K24 AI51982 (Havlir) 04/15/2002 – 03/31/2015 NIH/NIAID Mid-Career Investigator Award in Patient-Oriented Research The goals of the career development award are to conduct innovative patient-based research, increase her mentorship role, and develop an international-based clinical research program.

T32 AI060530 (Havlir) 09/05/2005 – 07/31/2015 NIH/NIAID Training in HIV Translational Research The aim of this program is to train patient-based physician scientists in HIV translational research under the careful supervision of a small and carefully selected group of clinical and laboratory scientists.

P30 AI27763 (Volberding) 03/01/1997 – 08/31/2017 NIH/NIAID Center for AIDS Research The primary aim of the UCSF-GIVI CFAR is to nurture and sustain innovative multidisciplinary HIV research

U01AI099959 (Havlir) 06/01/2012 – 06/30/2015 NIH Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START) The major goal of this project is to test our Streamlined ART Start Strategy (START) in a RCT. Role: Principal Investigator

U01AI099959 SEARCH Supplement (Havlir) 01/01/2014 – 06/30/2015 NIH/NIAID Sustainable East Africa Research on Community Health Overall goal: Evaluate health, economic, education outcomes of CD4 independent ART in rural East Africa. The study intervention is designed to improve the continuum of care, reduce structural barriers for all populations and add on to evidence based interventions such as adult male circumcision

UM1AI068636 (Kuritzkes) - Brigham & Women’s Hospital 01/01/2014 – 11/30/2014 Co-Vice Chair of the Tuberculosis TSG Role: Subcontract PI

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Anke Hemmerling Project Director

eRA COMMONS USER NAME (credential, e.g., agency login) ANKEH1 EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Humboldt University Berlin, Germany MD 1991 - 1999 Medicine Humboldt University Berlin, Germany PhD 1999 - 2003 Medical Sciences Humboldt University DRK Kliniken Westend Berlin Residency 2000 - 2003 Obstetrics & Gynecology University of California at Berkeley, USA MPH 2004 Public Health

A. Personal Statement In my role as the project director of the Microbicide Research and Development Program at UCSF, I successfully implemented two clinical trials (phase 1 and 2 clinical trials) at UCSF: the phase 1 safety study and phase 2a colonization efficiency and safety study of Lactobacillus crispatus CTV-05 (LACTIN-V), another live biotherapeutic product for vaginal health. These studies were important for the development of Mucocept®, as they established data on safety and colonization efficiency of an unmodified Lactobacillus strain, as well as acceptability data. I prepared all essential documents for both studies, participated in the IND process, was responsible for the IRB and CCRC applications, and selected the clinical research team. I was also involved in data analysis, wrote the study reports and was the first author on the resulting publications. Recently, I completed a study assessing the public’s perception, knowledge and attitudes around genetically modified live biotherapeutic products to inform the design of subsequent clinical studies of Mucocept®. My years as the administrative liaison between Osel, Inc. and various departments at UCSF prepared me well for my role as a general IPCP-MucoCept program coordinator as well as Co-Director for Project 3 of this proposal, serving as a coordinator for the various sites within UCSF (labs of Drs Chiu, Miller and Moscicki) as well as our collaborator Dr Kaul in Toronto and Dr Anton at UCLA, organizing regular conference calls, sample shipments, annual reports and budget tracking.

B. Positions and Honors Positions and Employment 2000 - 2003 Residency, Dept. Obstetrics and Gynecology. DRK Westend Berlin, Germany 2004 - 2007 Bixby Fellow of Population, Family Planning and International Health. Bixby Program. School of Public Health, UC Berkeley 2004 - 2007 Director of Special Health Projects, Venture Strategies for Health and Development, Berkeley 2007 – present Project Director, UCSF Microbicide Research and Development Program Bixby Center for Global Reproductive Health, University of California at San Francisco 2012 – present Lecturer, University of California Berkeley, School of Public Health 2012 – present Lecturer, UCSF Global Health Sciences Masters Program 2013 – present Scientic advisor, Coalition Advancing Multipurpose Innovations for Reproductive Health (CAMI)

Other Experience and Professional Memberships 2007 – present Steering Committee, Coalition Advancing Multipurpose Innovations

Honors 2001 Research Award of the German Society of Psychosomatic Ob & Gyn 2004 Research Award for ‘Best Medical Dissertation of 2003’ by the German Collegium of Psychosomatic Medicine (German Section of ICP)

C. Selected Peer-reviewed Publications Selection of 15 (out of 21 peer-reviewed) articles and book chapters:

Peer-reviewed Articles 1. Romano J, Manning J, Hemmerling A, McGrory E, Young Holt B. Multipurpose Prevention Technologies: Developing a Target Product Profile and Prioritizing the Pipeline to Inform Funder Investment and Developer Focus. Antiviral Research. In press 2013. 2. Harrison PF, Hemmerling A, Romano J et al. Developing Multipurpose Reproductive Health Technologies: An Integrated Strategy. AIDS Research and Treatment. In press 2013. 3. Hemmerling A, Harrison WG, Brown JM et al. Trypan Blue Staining to Determine Vaginal Exposure in Two Types of Plastic Vaginal Applicators Containing Two Different Microbicide Formulations. Sexually Transmitted Diseases. Sex Transm Dis. 2012 Sep;39(9):710-2 4. Ngugi BM, Hemmerling A, Bukusi E et al. Effects of BV-Associated Bacteria and Sexual Intercourse on Vaginal Colonization with the Probiotic Lactobacillus crispatus CTV-05. Sex Transm Dis. 2011 Nov;38(11):1020-1027. 5. Hemmerling A, Cohen CR. Probiotics: the Potential for a Live Microbicide to Prevent HIV. J Acquir Immune Defic Syndr. 2011 Mar 1;56(3):e98-e101 6. Hemmerling A, Harrison W, Schroeder A et al. Phase 2a Study Assessing Colonization Efficiency, Safety and Acceptability of Lactobacillus crispatus CTV-05 (LACTIN-V) in Women with Bacterial Vaginosis. Sex Transm Dis. 2010 Dec;37(12):745-50. 7. Hemmerling A, Harrison W, Schroeder A et al. Phase 1 Dose-ranging Safety Trial of Lactobacillus crispatus CTV-05 (LACTIN-V) for the Prevention of Bacterial Vaginosis. Sex Transm Dis. 2009 Sep;36 (9):564-9. 8. Hemmerling A, Potts M, Walsh J, Young-Holt B, Whaley K, Stefanski DA. Lime Juice as a Candidate Microbicide? An Open-Label Safety Trial of 10% and 20% Lime Juice Used Vaginally. Journal of Women’s Health 2007; 16 (7): 1041-1051 9. Hemmerling A. The safety of Misoprostol. International Journal of Gynecology and Obstetrics 2006; 94 (Suppl. 2): S149-150 10. Potts M, Hemmerling A. The worldwide burden of postpartum haemorrhage. International Journal of Gynecology and Obstetrics 2006; 94 (Suppl. 2): S116-121 11. Miller S, Lehman T, Campbell M, Hemmerling A, Anderson SB, Rodriguez H. Misoprostol and Declining Abortion-Related Morbidity in Santo Domingo, Dominican Republic: A Temporal Association. British Journal Obstetrics and Gynaecology 2005; 112: 1291-1296 12. Hemmerling A, Kentenich H. Emotional impact and acceptability of medical abortion with mifepristone– a German experience. J Psychosom Obstet Gynaecol 2005 ; 26 : 23-31 13. Ulrich D, Gagel DE, Hemmerling A, Pastor VS, Kentenich H. Couples becoming parents : something special after IVF ? J Psychosom Obstet Gynaecol 2004 ; 25 : 99-113

Book Chapters 1. Hemmerling, A. Infertility in developing countries – scope, psychosocial burden and need for action. In: Murthy P, Smith CL (eds). Women’s Global Health and Human Rights. Jones and Bartlett Publishers. Boston 2009. p 299-310. 2. Hemmerling A. Overview of misoprostol studies in postpartum hemorrhage. In: B-Lynch C, Keith L, Lalonde A, Karoshi M. (eds.) A textbook of postpartum hemorrhage. A comprehensive guide to evaluation, management and surgical intervention. Sapiens Publishing. Duncow, UK. 2006. p 162-68.

D. Research Support

A107782 Cohen (PI) 12/2006 – 08/2009 Osel, Inc. (Industry Sponsor) Phase 1 and phase 2a clinical trial assessing vaginal probiotic LACTIN-V for prevention of Bacterial Vaginosis. The goal of these studies was to conduct clinical trials assessing safety, colonization efficiency and acceptability of L. crispatus CTV-05 in health women and women with bacterial vaginosis. Role: Project Director

NIH-FIC D43 TW007388-01 Cohen (PI) 04/2009 – 06/2010 NIH/NIAID Fogarty International Center KEMRI-UCSF Infectious Disease Research Training Program: This training program was a sandwich program in which selected pre-doctorates and post-doctorates enrolled in the INTROMID program at KEMRI participate in an intensive training program at both KEMRI at UCSF. Role: Co-Investigator

A114676 05/2010 – 08/2010 NIH NIH support for Microbicides 2010 Satellite Symposium “Probiotics: Potential for a Live Microbicide”. Role: Organization of symposium, preparation of conference report.

AI071978 Cohen (PI) 09/2009 – 08/2013 NIH Phase 0 clinical trial assessing bioenhanced vaginal probiotic Mucocept (with GusA) for HIV prevention. The redefined goal of this study is to perform preparatory work for early clinical trials of MucoCept. The originally planned pre-phase 1 study with the recombinant GusA-expressing L. jensenii strain as an interim step before assessing Mucocept was modified after consultations with the NIH, and implemented completed a study assessing the public’s perception, knowledge and attitude around genetically modified live biotherapeutic products to inform the design of subsequent clinical studies of Mucocept®. Role: Project Director

Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Hiatt, Robert A. Professor and Chair, Epidemiology and Biostatistics Director of Population Sciences and Deputy Director, eRA COMMONS USER NAME (credential, e.g., agency login) rhiatt Helen Diller Family Comprehensive Cancer Center, University of California San Francisco EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Michigan, Ann Arbor, MI B.A. 1964 Zoology University of Michigan Med School, Ann Arbor, MI M.D. 1968 Medicine San Francisco General Hospital, San Francisco, CA Internship 1969 USPHS Hospital, San Francisco, CA Residency 1971 Internal Medicine University of California, Berkeley, CA MPH, PhD 1972, 1980 Epidemiology

A. Personal Statement I am Professor and Chair of Epidemiology and Biostatistics at UCSF and also the Director of Population Sciences and Associate Director for the Helen Diller Family Comprehensive Cancer Center. I came to UCSF in 2003 after being the first deputy director of the National Cancer Institute's Division of Cancer Control and Population Sciences, where, among other things, I oversaw the extramural cancer epidemiology, health disparities, health outcomes and cancer surveillance programs. I had primary extramural responsibility for the development of the NCI’s Cohort Consortium. I have been the Director of Population Sciences at the CCC since 2003 and have overseen the development of new research programs there. I was the founding director of the UCSF Doctoral Program in Epidemiology and Translational Science from 2008-13 and a primary contributor to the recent NCI meeting on the Future of Epidemiology in the 21st Century. I am a past president of the American College of Epidemiology and the American Society of Preventive Oncology. I have a demonstrated record in breast cancer research and of leading successful and productive transdisciplinary research projects. My current work on studies of breast cancer and the environment have led me to become interested and concerned about complex etiologic relationships of multiple factors and their interactions. I have developed a complex systems model for postmenopausal breast cancer etiology that combines factors from biologic, environmental, behavioral and sociocultural domains to highlight these complex interactions and to suggest opportunities for filling gaps in our knowledge and lead to effective interventions at multiple levels and across the lifecourse.

B. Positions and Honors Positions and Employment 1972-1973 Research Associate, Haile Sellassie I. University Addis Ababa, Ethiopia, George Williams Hooper Foundation, UCSF, San Francisco, CA 1974 Clinical Instructor in Medicine & Director, Employee Health Service, San Francisco General Hospital and University of California Medical School, San Francisco CA 1974, 76-81 Physician, Berkeley and Hayward Industrial Medical Groups, Berkeley and Hayward, CA 1974-1976 Chief, Parasitology Section, San Juan Laboratories, San Juan, Puerto Rico, Center for Disease Control, US Public Health Service 1977-1998 Epidemiologist, Senior Epidemiologist (77-90), Assistant Director (91-98), Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 1980-1987 Lecturer, Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco, CA 1981-1997 Lecturer, Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 1981-1986 Physician, Internal Medicine, Berkeley Family Practice Medical Group, Berkeley, CA

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 1988-1998 Associate Director for Detection, Prevention & Education (81-86), Director of Prevention Sciences (93-98), Northern California Cancer Center, CA 1998-2003 Deputy Director, Division of Cancer Control & Population Sciences, National Cancer Institute, NIH, Bethesda, MD 2003-2007 Senior Scientist, The Permanente Federation, Kaiser Permanente Medical Care Program, Oakland, CA 2003 - Director of Population Sciences and Deputy Director, UCSF Comprehensive Cancer Center and Professor of Epidemiology & Biostatistics, UCSF School of Medicine 2006 - Adjunct Investigator, Div. of Research, Kaiser Permanente Medical Care Program, Oakland, CA 2006 - Chair, Department of Epidemiology & Biostatistics, UCSF School of Medicine 2007 - Senior Advisor, Community Health Initiative, Kaiser Foundation Health Plan 2008 - Adjunct Professor, Division of Epidemiology, School of Public Health, University of California, Berkeley Awards and Honors 1967-1968 Victor Vaughn Medical Historical Society, University of Michigan Medical School 1968 Department of Health, Education and Welfare, Children’s Bureau Fellowship, Belgrade, Yugoslavia 1991 American Epidemiological Society 1998-1999 President, American College of Epidemiology 2001 National Institutes of Health Merit Award, Quality of Cancer Care Committee 2002 National Institutes of Health Merit Award, Cancer Progress Report; 2002, National Institutes of Health Director’s Award, Cancer Progress Report 2003-2004 President, American Society of Preventive Oncology 2010 Nattional Cancer Institute, Visiting Scholar, Epidemiology & Genetics Program. Professional Qualifications Medical Licensure: California C-32334, Michigan 29031 1974 American Board of Preventive Medicine, Fellow 1971 American Board of Internal Medicine, Eligible 1986 American College of Epidemiology, Fellow

C. SELECTED PUBLICATIONS (Since 2010 - total of 178) 1. Windham GC, Pinney SM, Sjodin A, Lum R, Jones RS, Needham LL, Biro F, Hiatt RA, Kushi LH. Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in U.S. girls. Environ Research 2010; 110:251-257. PMCID: PMC2844779. 2. Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, Kushi LH, Erdman C, Hiatt RA, Rybak ME, Calafat AM and the Breast Cancer and Environment Research Centers. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates and phenols and pubertal stages in girls. Environ Health Perspectives 2010; 118(7):1039-1046. PMCID: PMC2920905. 3. Deardorff J, Ekwaru MA, Kushi L, Ellis B, Greenspan LC, Mirabedi A, Landaverde EG, Hiatt RA. Father absence, BMI and pubertal timing in girls: differential effects by family income and ethnicity. J Adolesc Health 2011; 48:441-7. PMCID: PMC3079910. 4. Hiatt RA. Epidemiologic Basis of the Role of Environmental Endocrine Disruptors and Breast Cancer. In Russo J. Breast Cancer and the Environment. 2011 5. Willet WC, Colditz GA, Hiatt RA. Combating environmental causes of cancer. Response to Christiani. N Engl J Med 2011;364:2266. PMID:21651410. 6. Deppen SA, Aldrich MC, Hartge P, Berg CD, Colditz GA, Petitti DB, Hiatt RA. Cancer screening: the journey from epidemiology to policy, Ann Epidemiol 2012; 22:439-45. PMID:22626002. 7. Braithwaite D, Izano M, Moore DH, Kwan ML, Tammemagi MC, Hiatt RA, Kerlikowshe K, Kronke CH, Sweeney C, Habel L, Castillo A, Weltzien E,Caan B. Smoking and survival after breast cancer diagnosis: a prospective observational study and systematic review.Breast Cancer Res Treat 2012;136:521-533. PMID 23053660 8. Khoury M, Lam T, Ioannidis J, Hartge P, Spitz M, Buring J, Chanock S, Croyle R, Goddard K, Ginsburg G, Herceg Z, Hiatt R, Hoover R, Hunter D, Kramer B, Lauer M, Meyerhardt J, Olopade O, Palmer J, Sellers T, Seminara D, Ransohoff D, Rebbeck T, Tourassi G, Zauber A, Winn D, Schully S. Transforming PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev 2013;22:508-16. PMCID: PMC3625652. 9. Hiatt RA, Sulsky S, Aldrich MC, Kreiger N, Rothenberg R. Promoting innovation and creativity in epidemiology for the 21st century. Ann Epidemiol 2013; 23:452-454. PMID 23790350 10. Biro FM, Greenspan LC, Galvez MP, Pinney SM, Teitelbaum S, Windham GC, Deardorff J, Herrick R, Succop PA, Hiatt RA, Kushi LH, Wolff MS. Onset of breast development in a longitudinal cohort. Pediatrics 2013;132:1019-27. PMID 24190685 11. Barrett MA, Humblet O, Hiatt RA, Adler N. Big Data and disease prevention: from quantified self to quantified communities. Big Data. Sep 2013;1(3):168-175. doi:10.1089/big.2013.0027 12. Kale A, Deardorff J, Lahiff M, Laurent C, Galvez M, Greenspan L, Hiatt RA, Pinney SM, Teitelbaum SL, Windham G, Biro FM, Wolff MS, Mirabedi A,Lasater M, Kushi LH. Breastfeeding versus formula-feeding and girls' pubertal development. Maternal and Child Health Journal. 2014; Jun 11. PMID:24916206 13. Humblet O, Diaz-Ramirez LG, Blames JR, Pinney SM, Hiatt RA. Polyfluoroalkyl chemicals and asthma among children 12-19 years of age. Environ Health Perspectives 2014: Jun 6 [Epub ahead of print] PMID:24905661. 14. Hiatt RA, Porco T, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux A, Joseph G, Kushi L, Moasser M, Werb Z, Windham G, Rehkopf D. A multi-level complex systems model of breast cancer incidence. Cancer Epidemiol Biomarkers Prev 2014 (in press). 15. Izano M, Din N, Satariano WA, Hiatt RA, Braithwaite D. Smoking and mortality after breast cancer diagnosis: The Health and Functioning in Women Study. Cancer Med 2014 (in press).

D. Research Support Ongoing Research Support 2P30 CA82103-14 (McCormick) 09/19/2012 – 05/31/17 NIH/NCI UCSF Helen Diller Family Comprehensive Cancer Center Support Grant Major goals: The Cancer Center Major goals: Support Grant provides support for administration and infrastructure for the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). Role: Director of Population Sciences and Associate Director of the HDFCCC

01 ES019457 (Hiatt) 09/01/10 – 04/30/15 NCI/NIEHS Breast Cancer and the Environment Research Program Coordinating Center Major goals: The BCERP CC works with three integrated cohorts of girls in centers across the country to study potential environmental causes of breast cancer by focusing on factors in puberty and adolescence. Role: Principal Investigator

The Robert Wood Johnson Foundation (Adler) 09/03/10 – 04/30/15 The Robert Wood Johnson Health and Society Scholars Program Major goals: To implement an interdisciplinary, post-doctoral training program focused on the contextual, behavioral and biological determinants of health in order to improve the health of populations. Role: Primary Faculty and Mentor

P60 MD006902 (Bibbins-Domingo) 08/27/12 – 02/28/17 NMHHD The Center for Health and Risk in Minority Youth and Adults (CHARM) - Major goals: To create CHARM), a new comprehensive center of excellence that will focus on chronic conditions and disease risk in diverse populations in adolescence to young adulthood to impact minority health and health disparities. Role: Co-Investigator

Leveraging the California Cancer Registry (Hiatt) 7/1/13 – 9/31/14 California HealthCare Foundation

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): To examine the barriers and opportunities for leveraging the California Cancer Registry (CCR) for measuring and improving the quality of cancer care through public reporting of cancer quality metrics by provider. Role: Principal Investigator

Study of Etiology of Esophageal Cancer in Tanzania (SEEC-Tanzania) 2/14/14 – 2/13/16 NCI/NIH Major goals: To study the high incidence of esophageal cancer (EC) in Eastern Africa by summarizing incidence and mortality rates in registries, by characterizing cases retrospectively from medical record review and by performing a case-control study to determine the potential etiologic factors in Dar es Salaam, Tanzania. Role: Project Leader

COMPLETED Research Support

RO1 (Shim) 07/01/10 - 06/30/14 NIH/NHGRI Conceptions of Race and Ethnicity used in Gene-Environment Interaction Studies Major goals: To anticipate and analyze how conceptions of race and ethnicity used in gene-environment interaction (GEI) research influence societal understandings of race, ethnicity, and individual and group identity. Role: Co-Investigator U01 ES019435-01 (Kushi) 09/03/10 - 04/30/13 NCI/NIEHS The CYGNET Study: Environmental and Genetic Determinants of Maturation of Girls Major goals: To pursue hypotheses related to early development, puberty and adolescence with a focus on the influence of social determinants including socioeconomic status, race and ethnicity, the built environment, and other related issues like assessments of wealth, residential segregation and various stress pathways that might explain various social factors affecting early development and maturation in girls. Role: Co-investigator

5995SC Esserman (UC Systemwide PI) 01/01/10 - 12/31/12 UC Office of the President, Multi-campus Research Programs and Initiatives (MRPI) award Athena Breast Health Network Major goals: The aim of the MRPI award is to support innovative collaborations that assemble multidisciplinary, statewide teams of UC experts to focus their efforts around specific research areas important to California. MRPI funding for Athena supports the development of an infrastructure, shared across all UC medical centers, to integrate clinical data with research and learning and thus accelerate advancements in breast cancer prevention, screening, and treatment. Role: Co-Investigator

15QB-8301 (Hiatt) 05/01/09 – 04/30/12 California Breast Cancer Research Program New Paradigm of Breast Cancer Causation and Prevention Major goals: This project takes a transdisciplinary approach to develop a model for breast cancer causation and etiology that takes into account multiple disciplinary perspectives from the biologic to the sociologic in order to provide common ground for understanding and to point up gaps in knowledge about breast cancer etiology that require further investigation. Role: Principal Investigator

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page BIOGRAPHICAL SKETCH NAME POSITION TITLE Nancy K. Hills Assistant Professor, Stroke Sciences Group eRA COMMONS USER NAME Department of Neurology NANCYHI EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) College of William and Mary, Williamsburg, VA BA 1969-1973 English Literature College of William and Mary, Williamsburg, VA MA 1974-1980 English Literature Boston University, Boston, MA MBA 1981-1983 Marketing Research University of California, Berkeley MA 1995-1997 Biostatistics University of California, Berkeley, CA PhD 1997-2005 Epidemiology

A. Positions

POSITIONS and EMPLOYMENT 1997-2003 Biostatistician, Department of Pediatrics, UCSF 2003-2005 Specialist II, Department of Neurology, UCSF 2005-2007 Adjunct Instructor, Department of Neurology, UCSF 2007-present Asst. Adjunct Professor, Department of Neurology, UCSF 2013-present Joint appointment, Department of Epidemiology and Biostatistics, UCSF

OTHER EXPERIENCE and PROFESSIONAL MEMBERSHIP 2013-present Consultant for Master’s Program in Monitoring & Evaluation, Mzumbe University, Tanzania 2012 International online discussion group leader, Biostat 200, TICR, UCSF 2011-present Instructor, Biostatistics, Hanoi School of Public Health, Hanoi, Vietnam (through PEPFAR) 2011-present Instructor, Biostatistics, Pasteur Institute, Ho Chi Minh City, Vietnam 2010-present Instructor, Biostatistics, Masters’ Program in Global Health Sciences, UCSF 2009-present Biostatistics Consultant, CTSI 2010-present Member, American Statistical Association 2004-present Member, American Heart Association 2007-present Member, American Academy of Neurology 2000-present Instructor, Principles of Epidemiology, UC Berkeley Extension 2000-2001 Instructor, Introductory Epidemiology and Biostatistics, San Jose State University 1996 Instructor, Department of Statistics, UC Berkeley

C. Peer-reviewed publications (in chronological order)

1. B Ovbiagele, Hills NK, Saver J, SC Johnston, “Antihypertensive medications prescribed at discharge after an acute ischemic cerebrovascular event,” Stroke, 2005 Sep;36(9):1944-7. 2. SA Josephson, Hills NK, Johnston SC, “How reliable is the NIH Stroke Scale? An analysis of video ratings. Cerebrovascular Diseases, 2006 22: 389-395. 3. B Ovbiagele, Hills NK, Saver J, SC Johnston, “Secondary-prevention drug prescription in the very elderly after ischemic stroke or TIA.” Neurology. 2006 Feb 14;66(3):313-8. 4. B Ovbiagele, Hills NK, SC Johnston, “Frequency and determinants of pneumonia and urinary tract infection during stroke hospitalization.” Journal of Stroke and Cerebrovascular Diseases. 2006 15:209- 13. 5. B Ovbiagele, Hills NK, Saver JL, Johnston SC; California Acute Stroke Prototype Registry Investigators, “Are racial differences in antihypertensive responsiveness reflected in usage after stroke?”J Stroke Cerebrovasc Dis, 2006 Nov-Dec;15(6):260-5. 6. B Ovbiagele, Hills NK, SC Johnston, “Lipid assessment and treatment patterns in hospitalized TIA and ischemic stroke patients”, Journal of Hospital Medicine. 2006 1:214-220. 7. NK Hills and SC Johnston, “Duration of hospital participation in a nationwide stroke registry is associated with improved quality of care: a longitudinal study,” BMC Neurology, 2006 6:20. 8. NK Hills and SC Johnston, “Why Are Eligible Thrombolysis Candidates Left Untreated?,” American

Journal of Preventive Medicine, 2006 Dec;31(6 Suppl 2):S210-6. Epub 2006 Nov 7. 9. NK Hills and SC Johnston, “Trends in usage of alternative antiplatelet therapy after stroke and TIA”, Stroke, 39:1228-1232, 2008. 10. NK Hills, Josephson SA, Lyden PD, Johnston SC, “Is the NIHSS certification process too lenient?”, Cerebrovasc Dis, 2009 27(5):426-32. Epub 2009 Mar 19. 11. Gardner MA, Hills NK, Sidney S, Johnston SC, Fullerton HJ, “The five-year cost of neonatal and childhood stroke in a population-based cohort,” Neurology. 2010 Feb 2;74(5):372-8. Epub 2010 Jan 6. 12. Nakagawa K, Hills NK, Kamel H, Maorabito D, Patel PV, Manley GT, Hemphill C, “The effect of decompressive hemicraniectomy of brain temperature after severe brain injury,” Neurocrit Care,2010 Nov.9. [Epub ahead of print] 13. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman RI. “Relationship between circulating platelet counts and ductus arteriosus patency following indomethacin treatment,” J Pediatr, 2010 Dec 30. [Epub ahead of print] 14. Hills NK, Fullerton HJ. Atherosclerotic stroke in children? A public health red flag (invited editorial). Ann Neurol. 2011 Nov;70(5):675-6. 15. Hills NK, Johnston SC, Sidney S, Zielinski B, Fullerton HJ. Recent trauma and acute infection are risk factors for childhood ischemic stroke: results of the Kaiser Pediatric Stroke Study. Ann Neurol., 2012 Dec;72(6):850-8.

Other Support For each of the professionals named on the budget pages, list the title, start and end dates; source of funding; and yearly amounts of all state, federal, commercial, and private funding support. Include this information for active grants, proposals under review, and proposals being prepared for submission. Indicate the percentage of effort for investigators in each project.

Nancy K. Hills

ACTIVE R01 NS062820 (HJ Fullerton, contact PI; G deVeber, PI) 8/5/09-7/30/14 20% effort NIH/NINDS $1,098,901 Vascular Effects of Infection in Pediatric Stroke (VIPS) This is an international 30-center observational study with the goal of determining whether recent infection and inflammation predict arteriopathy in children with arterial ischemic stroke. Role: Biostatistical support.

RAS-A116619 2/1/11-1/31/13 20% Thrasher Research Foundation $174,535 Stimulants and Childhood Stroke (StaCS) This is a case-control study nested within the cohort of the 2.5 million children enrolled in KPMCP from 1993- 2007 with the goal of determining whether ADHD medications increase the risk of childhood arterial ischemic stroke. Role: PI

BIOGRAPHICAL SKETCH

Name Judith Justice, PhD, MPH

Education 1975-1981 University of California, Berkeley Department of Anthropology Medical Anthropology Ph.D. 1981 Anthropology M.A. 1976 1968-1969 University of Pittsburgh, PA School of Public Health Public Health M.P.H. 1969

1966-1968 University of Pittsburgh, PA School of Social Work Social Welfare M.S.W. 1968

1961-1965 Tufts University, Boston, MA Psychology B.S. 1965

Personal statement My academic career has focused on teaching medical anthropology and global health at UCSF, in addition to teaching global health courses as a Visiting Professor at UC Berkeley and Case Western Reserve University. I have conducted research in South and Southeast Asia, Africa, and the U.S., and served as a consultant for foundations and international organizations, in addition to working with the United Nations and UNICEF/India. Research interests include international and national health policy; foreign aid to the health sector; health and development; reproductive and child health; new vaccines and immunization; cultural context of emerging and re-emerging infectious diseases; and the role of NGOs. My research includes multi-country studies of the political and cultural dimensions of reproductive and child health in Egypt, India, Indonesia and Uganda, and a study on adoption of new vaccines in Bangladesh, Philippines, and Uganda. Other immunization related research includes a 4-year collaborative study with the University of Oslo (funded by the Norwegian Research Council) and a Gates Foundation funded study on the impact of polio eradication on routine immunization and primary care. I’ve also studied special health problems related to stigmatized and chronic diseases (e.g., HIV/AIDS, leprosy and tuberculosis), including among ethnic and minority populations in the U.S. In Nepal, I’m conducting a restudy of my earlier research on foreign assistance to the health sector, Policies, Plans and People: Foreign Aid and Health Development. Work focusing on HIV/AIDS includes a comparative study of home-based care and the role of community health volunteers within the broader context of volunteerism in poorer countries; documentation of the Gates Foundation supported-HIV/AIDS Prevention Project in India (Avahan); an NIH funded study on religious organizations and HIV/AIDS in Malawi, evaluation of UNAIDS in India, in addition to review of HIV/AIDS programs in Vietnam and Nepal.

Positions and Honors 2007-current Associate Professor of Medical Anthropology and Health Policy, (Adjunct/WOS), Department of Anthropology, History and Social Medicine, UCSF. 1985-2006 Associate Professor of Medical Anthropology and Health Policy, Department of Anthropology, History and Social Medicine, and Institute for Health Policy Studies, UCSF 1998 Visiting Professor, University of California at Berkeley, teaching globalization and health. 1993 & 1996 Flora Stone Mather Visiting Professor at Case Western Reserve University, teaching global health and development. (Also Visiting Professor at CWRU in 1993, teaching global health.)

1 1985-1986 Congressional Fellow for American Anthropological Association with American Political Science Association Congressional Fellowship Program. Worked with Congressional Committees and individual members of the U.S. Congress on legislation for domestic health, long-term care for the elderly, and foreign assistance. 1984 Postdoctoral Fellow, Institute for Health Policy Studies, School of Medicine, University of California at San Francisco. Conducted field study of social and epidemiological aspects of health and leprosy in Bhutan. Follow-up visits in 1985, 1990, 1999, 2009. 1982-2013 Global Health Collaboration, Consultation, Evaluation for United Nations agencies, bilateral donor organizations (US, British, Swiss, Danish), non-government organizations, and foundations (Gates, Ford Rockefeller, Carnegie) on program evaluation, organizational assessment, program planning and management, including project on reproductive and child health, vaccines and immunization, infectious diseases, primary health care, community participation, health sector review and reform, etc. 1982-83 Postdoctoral Fellow in Anthropology of Aging and Aging Health Policy, School of Medicine, University of California at San Francisco.

Honors and Awards 1999-2000 Fulbright Senior Scholar Award for the study of foreign assistance to the health sector in Nepal, "Re-examining the Fit Between International Health Policies and Local Realities in Nepal." 1997 & 1999 Team Residency at the Rockefeller Foundation's Bellagio Study and Conference Center, Italy for the Research Project on "Political and Cultural Dimensions of International Health Policy: Lessons from the Child Survival Initiative." 1996 Flora Stone Mather Visiting Professor, Case Western Reserve University. 1991 Resident Scholar at the Rockefeller Foundation's Bellagio Study and Conference Center, Italy, for summer 1991. 1988-1990 Advanced Research Fellowship in Foreign Policy Studies, Social Science Research Council/Ford Foundation. 1985-1986 Congressional Fellowship from the American Anthropological Association. 1982-1983 National Research Service Award, National Institute of Aging. Postdoctoral Fellowship for Anthropology and Aging at University of California at San Francisco. 1975-1980 National Institute of General Medical Sciences Traineeship for graduate study in Medical Anthropology at University of California at Berkeley. 1968-1969 U.S. Public Health Services Training Grant for study of Public Health, School of Public Health, University of Pittsburgh, Pennsylvania. 1966-1968 National Institute of Mental Health Fellowship for Study of Social Welfare, School of Social Work, University of Pittsburgh, Pennsylvania.

Selected Publications Books 1986 Justice, J. Policies, Plans and People: Culture and Health Development in Nepal. University of California Press. (Reprinted in paperback edition and re-titled Policies, Plans and People: Foreign Aid and Health Development. University of California Press, 1989.) Articles (Selected) 2014 Nyirenda, Lot, Kristin Ingstad Sandberg, Judith Justice. When are Health Systems Ready for New Vaccines? The Introduction of Pneumococcal Vaccine in Malawi. Forum for Development Studies, Routledge (DOI: 10.1080/08039410.2014.894936). 2013 Closser, Svea, J. Justice, et al. The Impact of Polio Eradication on Routine Immunization and Public Health Care: A Mixed Methods Study. The Journal of Infectious Diseases. 2 2013 Kristin Ingstad Sandberg and Judith Justice. “National Commitments and Global Objectives.” In Protecting the World’s Children: Immunisation Policies and Practices, edited by Sidsel Roalkvam, Desmond McNeill, and Stuart Blume. University of Oxford Press. 2012 Closser, Svea, J. Justice, et al. Methods of Evaluating the Impact of Vertical Programs on Health Systems: Protocol for a Study on the Impact of the Global Polio Eradication Initiative on Strengthening Routine Immunization and Primary Health Care. BMC Public Health, 2012, 12:728 (http://www.biomedcentral.com/1471-2458/12/728). 2000 Justice, J. "The Politics of Child Survival." In Global Health Policy, Local Realities: The Fallacy of the Level Playing Field, edited by Linda M. Whiteford and Lenore Manderson, Series on Directions in Applied Anthropology. Lynne Rienner Publishing Company. 1999 Justice, J. “Neglect of Cultural Knowledge in Health Planning: Nepal's Assistant Nurse- Midwife Program.” In Anthropology in Public and International Health, edited by Robert A. Hahn, Oxford: Oxford University Press, 1999. 1995 Justice, J. “The Political and Cultural Dimensions of International Health Policy: Lessons from the Child Immunization Initiative.” In Social Science and Immunization, edited by Pieter Streefland, Royal Tropical Institute, Amsterdam. 1995 Justice, J. From Rhetoric to Reality: Reducing Maternal Mortality and Disabilities." In Safe Motherhood and Essential Obstetric Care, ed. Diana Measham, New York: Family Care International and the United Nations. 1994 Justice, J. "A New Look at Old Cures." Choices, Journal of the United Nations Development Programme, pages 22-26. 1992 Gilman, Stuart C., J. Justice, K. Saepharn, G. Charles. “The Use of Traditional and Modern Health Care Services by Laotian Mien Refugees in the United States.” The Western Journal of Medicine, Special Issue on Cross-Cultural Medicine, Vol. 157: 310-315. 1991 Justice, J. Book Review of Leprosy, Racism and Public Health: Social Policy in Chronic Disease Control, by Zachary Gussow, Westview Press, 1989. In The American Ethnologist , Vol. 18, No. 2. 1991 Justice, J. Book Review of Current Health Policy Issues and Alternatives: An Applied Social Science Perspective, edited by Carole Hill, University of Georgia Press, 1986. In Medical Anthropology Quarterly, Vol.5, No.2.

Research Awards- 4 most recent of 16 “What Determines the Impact of Polio Eradication on Health Systems?” Principal Investigator: Svea Closser, Middlebury College. Research Advisor: Judith Justice Funding Agency: Gates Foundation: 2011-2012 Conducted Nepal Country Study “Multi-disciplinary Approach to Explaining Differential Immunization Coverage.” Principal Investigator/Research Leader: Sidsel Roalkvam, Center for Development and Environment and Section for International Health, University of Oslo, Norway; Research Advisor, Judith Justice. Funding Agency: Norwegian Research Council: 2008-2012 “Integrated Primary Health Care and Workforce Training in Zomba District, Malawi: Health Systems Strengthening” Principal Investigators: William Rankin, PhD and Jones Laviwa, MA Funding Agency: The Doris Duke Charitable Foundation, African Health Initiative: 2008-2009 “Malawi Christians and Muslims: HIV Prevention and Care” Principal Investigator: Sally Rankin Co-Investigators: Judith Justice, Ellen Schell Funding: National Institutes of Health (NIH): 2006-2009 3 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE James G. Kahn Professor eRA COMMONS USER NAME (credential, e.g., agency login) JGKAHN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Harvard University, Cambridge, MA — 1975-77 History of Science Wesleyan University, Middletown, CT BA, MALS 1980, 1981 Science in Society Albert Einstein College of Medicine, Bronx, NY MD 1986 Medicine University of California, Berkeley MPH 1988 Epidemiology

A. Personal Statement I have more than two decades’ experience in the empirical and modeled assessment of the cost, effects, and cost-effectiveness of global health interventions, programs, and policies, with more than 75 publications in this area. In the 1990s I completed several cost-effectiveness analyses (CEAs) of HIV prevention in injecting drug users in the U.S. I then conducted HIV CEAs in resource-poor settings, including PMTCT and anti-retroviral treatment (ART). I was the PI for PANCEA (Prevent AIDS: Network for Cost- Effectiveness Analysis), a study of the unit costs of 8 HIV prevention strategies in 5 countries, the largest HIV prevention cost study until 2013. For 15 years (now in years 16-20), I have been a co-investigator and UCSF PI for the NIDA-funded “Making Better Decisions: Policy Modeling for AIDS and Drug Abuse”. In 2006 I published the first CEA on male circumcision for HIV prevention, and in 2011, I published the only randomized trial-based CEA of lab monitoring for ART, in the British Medical Journal. Since 2006, I have studied other health conditions, including: in 2006, a CEA on hip devices; in 2009, a CEA on TB screening & treatment; in 2012, cost and CEA studies for a community integrated prevention campaign to deliver HIV testing, bed nets, and water filters in Kenya; in 2011 & 2013, CEAs of screening and treatment for gestational diabetes; and in 2013, CEAs on a garment to prevent maternal hemorrhage and test-guided therapy for Crohn’s disease. I have performed economic analyses for the World Health Organization, the Bill & Melinda Gates Foundation, the World Bank, the Centers for Disease Control and Prevention, and other US and global health agencies. I am the PI of the Global Health Decisions project. In phase 1, “Global Health Intervention Review,” we summarized efficacy data for more than 150 interventions for 8 health conditions (including HIV), for the Kaiser Family Foundation. In Phase 2, we are examining HIV intervention effectiveness for specific target settings, and modeling disease burden reduction and cost-effectiveness for variable combinations of prevention and treatment interventions, via a user-friendly graphic web interface. I am the lead cost and cost-effectiveness investigator for SEARCH and related studies of ART expansion in Kenya & Uganda, including analyses of earlier use (EARLI) and rapid initiation of ART (STARTs). In the School of Medicine at UCSF, I lead two core economics courses: global health economics, and decision and cost-effectiveness analysis. I started and lead the newly formed UCSF Global Health Economics Consortium. I have mentored dozens of post- and pre-doctoral students and faculty over the past 25 years.

B. Positions and Honors

Positions and Employment 1986-1987 Intern, Pediatrics, Children’s Hospital, Oakland, CA 1987-1989 Resident, Preventive Medicine, University of California, Berkeley 1988-1989 International Health Fellow, International Health Program Office (IHPO), Centers for Disease Control (CDC) and Ministry of Health, Central African Republic 1989-1991 Fellow, Health Services Research and Health Policy, Institute for Health Policy Studies (IHPS), University of California San Francisco (UCSF) 1991-1992 Assistant Research Physician, IHPS/UCSF 1992-present Assistant, Associate and Full Professor, Dept. of Epidemiology & Biostatistics, IHPS, and Global Health Sciences, UCSF Other Experience and Professional Memberships 2001-2003 Member, Institute of Medicine panel on Public Financing of HIV Care 2008-2012 Chair, Health Policy and Social Sciences Review Committee, RAP funding program, UCSF 2009 Invited speaker, Institute of Medicine Roundtable on Administrative Costs in U.S. Health Care

Positions and Employment 1977 Harvard Scholarship for Academic Achievement 1986 International Health Fellowships (2), Albert Einstein College of Medicine

C. Selected Peer-reviewed Publications (from 92 peer-reviewed publications)

Most relevant to the current application 1. Kahn JG, Marseille E, Auvert B (2006) Cost-effectiveness of male circumcision for HIV prevention in a South African setting. PLoS Med 3(12): e517. doi:10.1371/journal. PMCID: PMC1716193 2. Kahn JG, Marseille EA, Bennett R, Williams BG, Granich R. Cost-Effectiveness of Antiretroviral Therapy for Prevention. Curr HIV Res. 2011 Oct 14. PMCID: PMC3529401 3. Kahn JG, Marseille E, Moore D, et al. CD4 cell count and viral load monitoring in patients undergoing antiretroviral therapy in Uganda: cost effectiveness study. BMJ. 2011 Nov 9;343:d6884. doi: 10.1136/bmj.d6884. PMCID: PMC3213243 4. Kahn JG, Muraguri N, Harris B, et al. Integrated HIV Testing, Malaria, and Diarrhea Prevention Campaign in Kenya: Modeled Health Impact and Cost-effectiveness. PLoS One. 2012;7(2):e31316. Epub 2012 Feb 8. PMCID: PMC3275624. 5. Kern E, Verguet S, Yuhas K, Odhiambo FH, Kahn JG, Walson J. Provision of bednets and water filters to delay HIV-1 progression: cost-effectiveness analysis of a Kenyan multi-site study. Tropical Medicine & International Health, 2013 Aug;18(8):916-24. doi: 10.1111/tmi.12127. Epub 2013 May 10. Not NIH-funded.

Additional recent publications of importance to the field (in chronological order) 1. Marseille E, Kahn JG, Mmiro F, Guay L, Musoke P, Fowler MG, Jackson JB. Cost effectiveness of single- dose nevirapine regimen for mothers and babies to decrease vertical HIV-1 transmission in sub-Saharan Africa. Lancet, 354: 803-9, 1999. PMID: 10485721. Not NIH-funded. 2. Marseille E, Kahn JG, Billinghurst K, Saba J. Cost-Effectiveness of the Female Condom in Preventing HIV and STDs in Commercial Sex Workers in Rural South Africa. Social Science and Medicine, 52:135-148, 2001. PMID: 11144911. Not NIH-funded. 3. Marseille EA, Hofmann PB, Kahn JG. HIV Prevention Should Be Funded Before HAART in Sub-Saharan Africa. Lancet 2002;359:1851-56. PMID:1204439. Not NIH-funded. Marseille E, Kahn JG, Sowedi M, Saba J. The costs and benefits of private sector provision of treatment to HIV-infected employees in Kampala, Uganda. AIDS 2006 20:907-14. PMID: 16549976. Not NIH-funded. 4. Marseille E, Dandona L, Marshall N, et al [Kahn JG last]. HIV prevention costs and program scale: data from the PANCEA project in five low and middle-income countries. BMC Health Serv Res. 2007 Jul 12;7:108. PMCID: PMC1936993 5. Pitter CS, Kahn JG, Marseille E, Lule JR, McFarland DA, Ekwaru JP, Bunnell R, Coutinho A, Mermin J. Cost-effectiveness of cotrimoxazole prophylaxis among persons with HIV in Uganda. J Acquir Immune Defic Syndr. 2007 Mar 1;44(3):336-43. PMID: 17327758. Not NIH-funded. 6. Auvert B, Marseille E, Korenromp EL, Lloyd-Smith J, Sitta R, Taljaard D, Pretorius C, Williams B, Kahn JG. Estimating the Resources Needed and Savings Anticipated from Roll-out of Adult Male Circumcision in Sub-Saharan Africa. PLoS ONE. 2008 Aug 6;3(8):e2679. PMCID: PMC2475667 7. Marseille E, Kahn JG, Pitter C, et al. The Cost-Effectiveness of Home-Based Provision of Antiretroviral Therapy in Rural Uganda. Appl Health Econ Health Policy. 2009;7(4):229-43. PMCID: PMC2912402 8. Burgos JL, Kahn JG, Strathdee SA, et al. Targeted screening and treatment for latent tuberculosis infection using QuantiFERON-TB Gold is cost-effective in Mexico. Int J Tuberc Lung Dis. 2009 Aug;13(8):962-8. PMCID: PMC2763545 9. Sutherland T, Downing J, Miller S, …, Kahn JG. Use of the non-pneumatic anti-shock garment (NASG) for life-threatening obstetric hemorrhage: a cost-effectiveness analysis in Egypt and Nigeria. PLoS One. 2013 Apr 30;8(4):e62282. doi: 10.1371/journal.pone.0062282. PMCID: PMC3640005

D. Research Support

Ongoing Research Support

RC4 AI092679-01 Kahn (PI) 10/01/2010 – 09/30/2013 Global Health Comparative Effectiveness: A Data Synthesis Method Applied to HIV The goal of this project is to develop estimates of efficacy, effectiveness, disease burden reduction, and cost- effectiveness for scaled up HIV prevention and treatment interventions. Role: PI

DA15612 Kahn (UCSF PI) 05/01/2013 – 02/28/2018 Making Better Decisions: Policy Modeling for AIDS and Drug Abuse The goal of this project is to develop and implement computer similar models to assess the cost-effectiveness of HIV and substance abuse prevention and treatment interventions. Role: UCSF subcontract PI

UM1 AI069502 Havlir (PI) 04/01/2013 – 3/31/2018 SEARCH This study will implement an RCT to test the effect of a test and treat strategy on community health in Africa. I will conduct cost and cost-effectiveness analyses. Role: Co-Investigator

U01AI099959 Havlir (PI) 06/01/2012 – 06/30/2015 Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (STARTs) The goal of this project is to test a streamlined ART initiation method in a randomized, controlled trial in 24 clinics in Uganda. I will conduct cost and cost-effectiveness analyses. Role: Co- Investigator

UL1 RR024131 Johnston (PI) 10/01/2007 – 09/30/2016 UCSF Clinical and Translational Science Institute (CTSI) CTSI facilitates the rapid translation of research to improvements in patient and community health. Role: Co-Inv., Community Engagement and Health Policy program

U90HA2270 Myers (PI) 09/01/2011 – 08/31/2015 Systems Linkage and Access to Care Evaluation and Technical Assistance Center. This multi-site project supports the development and implementation of interventions to enhance HIV testing and diagnosis among out of care populations and to link and retain these populations to high quality HIV care. UCSF is the evaluation and support center for 7 state demonstration sites. Role: Co-Investigator

NIDA HIV Clinical Trials Network Sorensen (PI) 12/1/2011 – 6/30/2015 Project HOPE, CTN0049: Hospital Visit as Opportunity for Prevention & Engagement HIV-Infected Drug Users. We will conduct a cost-effectiveness analysis of this intervention. Role: Co-Investigator

Completed Research Support

California Health Care Foundation Coffman (PI) 11/01/2011 – 10/31/2012 Comparative Effectiveness Large Dataset Analysis Care (CELDAC) The goal is to develop a system to provide technical guidance and support to researchers interested in conducting comparative effectiveness research using large secondary data sets in the UCSF integrated data repository environment. Role: Co-Inv.

U01 AI069502 Supplement Havlir (PI) 1/1/2012 – 12/31/2013 This SEARCH study supplement continuation will plan an RCT to test the effect of a test and treat strategy on community health in Africa Role: Co-Investigator

CIDRZ (Univ of Alabama) Kahn (PI) 04/01/2007 – 12/31/2011 Cost-effectiveness of Programs in PMTCT and HAART in Africa This project assesses the cost-effectiveness of different PMTCT and ART programs. Role: PI

51436, Bill and Melinda Gates Foundation Macfarlane (PI) 11/01/2008 – 10/31/2011 Academic Learning Project (Twinning) The goal of this project was to develop and assess an academic partnership between UCSF and Muhimbili University of Health and Allied Sciences (MUHAS). Role: Co-Investigator

ARRA A113038 Johnston (PI) 10/01/2009 – 9/31/2012 UCSF CTSI Supplement: Comparative Effectiveness Large Dataset Analysis Care (CELDAC) The goal of this supplement is to develop a system to provide technical guidance and support to researchers interested in conducting comparative effectiveness research using large secondary data sets in the UCSF integrated data repository environment. Role: Project Director

World Health Organization Kahn (PI) 07/01/2008 – 06/30/2010 Cost-Effectiveness of Congenital Syphilis Elimination To assess the cost-effectiveness of testing and treatment for the elimination of congenital syphilis. Role: PI

Kaiser Family Foundation Kahn (PI) 03/01/2009 – 12/31/2009 Global Health Effectiveness Review This goal of this project was to review evidence on the effectiveness of global health intervention funded by the U.S. government. Role: PI

51568, Bill and Melinda Gates Foundation Kahn (PI) 07/01/2008 – 12/31/2009 High-Quality High-Volume Male Circumcision: Lessons from Eye Care The goal of this project was to convene a conference on adapting Aravind high-quality, high-volume surgical systems to adult male circumcision Role: PI

Vestegaard Frandsen Kahn (PI) 07/31/2008 – 07/31/2009 Cost and Cost-Effectiveness of Integrated Prevention Demonstration (Western Kenya) To assess the cost and cost-effectiveness of a community health campaign for HIV, diarrhea, and malaria. Role: PI

BIOGRAPHICAL SKETCH NAME POSITION TITLE Sarah B Macfarlane Professor eRA COMMONS USER NAME (credential, e.g., agency login) SBMACFARLANEEDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Lancaster, UK BA (Hons) 1968 Economics London School of Economics, UK MSc Econ 1969 Operational research London University, UK PhD 2010 Medical statistics A. Personal Statement I am a professor in the Department of Epidemiology and Biostatistics in the School of Medicine at UCSF with 35 years of global health professional experience. I led the UCSF partnership with Muhimbili University of Health and Allied Sciences (MUHAS) and served as the principal investigator of the Bill & Melinda Gates funded MUHAS-UCSF Academic Learning Project (ALP). The ALP focused on academic institutional capacity building and facilitated curriculum revision and faculty development across programs at all the professional schools at MUHAS. I coordinated academic input from all UCSF’s schools and provided project direction. My academic focus is on the role of universities in improving population health, and I co-edited a supplement to the Journal of Public Health Policy on the ALP (published in December 2012) entitled: Universities in Transition for Better Health Outcomes. Throughout my career, I have also worked on research capacity building first as a reader at the Liverpool School of Tropical Medicine in the United Kingdom, then as Associate Director at the Rockefeller Foundation, and now as a founding faculty member of UCSF Global Health Sciences. I have taught epidemiology, statistics, information systems and development studies to postgraduate students in the UK, US and on short term courses around the world. B. Positions and honors Positions and Employment 1965-1969 Research Fellow, Operational Research (Health Services) Unit, Department of Applied Statistics, The University of Reading, UK. 1969-1974 Research Assistant, Statistical Research Group, Department of Mathematical Statistics, The University of Stockholm, Sweden. 1975-1985 Lecturer, Department of Tropical Paediatrics and Child Health, Liverpool School of Tropical Medicine, The University of Liverpool, UK. 1985-1998 Senior Lecturer, Liverpool School of Tropical Medicine. 1985-1998 Head, Unit for Statistics and Epidemiology, Liverpool School of Tropical Medicine. 1994 Visiting Faculty member, Department of Population and International Health, Harvard School of Public Health, Harvard University. 1998-2000 Reader in Statistics and Epidemiology, Liverpool School of Tropical Medicine. 1998-2004 Associate Director, Health Equity Theme, The Rockefeller Foundation, New York. 2004- 2006 Visiting Professor, Department of Epidemiology and Biostatistics, The University of California, San Francisco (UCSF). 2004- 2006 Senior Advisor, Global Health Sciences, The University of California San Francisco. 2004- 2009 Coordinator of Intersect, a multi-disciplinary statistical capacity building project. 2006- 2010 Associate Professor, Department of Epidemiology and Biostatistics, UCSF. 2006- 2012 Director Program Development and Planning, UCSF Global Health Sciences. 2008 -2011 Director of the UCSF-MUHAS Academic Learning project 2010- now Professor, Department of Epidemiology and Biostatistics, UCSF. Honors 1995 The University of Liverpool Teaching and Learning Excellence Award. 1997 Chartered Statistician (CStat), Royal Statistical Society, UK. 2003 Fellow of the Faculty of Public Health (FFPH), Royal Colleges of Physicians, UK. C. Selected publications 1. Tache S, Kaaya E, Omer S, Mkony CA, Lyamuya E, Pallangyo K, Debas HT, Macfarlane SB. University partnership to address the shortage of healthcare professionals in Africa. Glob Public Health. 2008; 3(2):137-48. 2. Macfarlane SB, Agabian N, Novotny TE, Rutherford GW, Stewart CC, Debas HT. Think globally, act locally, and collaborate internationally: global health sciences at the University of California, San Francisco. Acad Med. 2008 Feb; 83(2):173-9.

3. Macfarlane SB, Jacobs M, Kaaya EE. In the name of global health: trends in academic institutions. J Public Health Policy. 2008 Dec; 29(4):383-401. 4. Ngassapa OD, Kaaya EE, Fyfe MV, Lyamuya EF, Kakoko DC, Kayombo EJ, Kisenge RR, Loeser H, Mwakigonja AR, Outwater AH, Martin-Holland J, Mwambete KD, Kida I, Macfarlane SB. Curricular transformation of health professions education in Tanzania: The process at Muhimbili University of Health and Allied Sciences (2008-2011). J Public Health Policy. 2012; 33 Suppl 1:S64-91. 5. Kaaya EE, Macfarlane SB, Mkony CA, Lyamuya EF, Loeser H, Freeman P, Kirumira EK, Pallangyo K, Debas HT. Educating enough competent health professionals: Advancing educational innovation at Muhimbili University of Health and Allied Sciences, Tanzania. PLoS Med. 2012 Aug; 9(8):e1001284. 6. Pemba S, Macfarlane SB, Mpembeni R, Goodell AJ, Kaaya EE. Tracking university graduates in the workforce: Information to improve education and health systems in Tanzania. J Public Health Policy. 2012; 33 Suppl 1:S202-15. 7. Masalu JR, Aboud M, Moshi MJ, Mugusi F, Kamuhabwa A, Mgimwa N, Freeman P, Goodell AJ, Kaaya EE, Macfarlane SB. An institutional research agenda: Focusing university expertise in Tanzania on national health priorities. J Public Health Policy. 2012; 33 Suppl 1:S186-201. 8. Mloka DA, Omer S, Mkony CA, Kisenge RR, Macfarlane SB, O'Sullivan PS. Health professions educators as agents of change in Tanzania: Creativity to implement new curricula. J Public Health Policy. 2012; 33 Suppl 1:S171-85. 9. Mkony CA, O'Sullivan PS, Owibingire SS, Fyfe MV, Omer S, Freeman P, Makubi A, Mloka DA, Portillo CJ, Leyna GH, Tarimo E, Kaaya EE, Macfarlane SB. Teaching and educational scholarship in Tanzania: Faculty initiative to improve performance of health professions' students. J Public Health Policy. 2012; 33 Suppl 1:S150-70. 10. Leshabari S, Lubbock LA, Kaijage H, Kalala W, Koehler G, Massawe S, Muganyizi P, Macfarlane SB, O'Sullivan PS. First steps towards interprofessional health practice in Tanzania: An educational experiment in rural Bagamoyo district. J Public Health Policy. 2012; 33 Suppl 1:S138-49. 11. Macfarlane, S.B. and Kaaya, E.E. (2012) Universities in Transition for better health outcomes: A Tanzanian Case Study. J Public Health Pol 33; S1, S3-S12. 12. Pallangyo, K., Debas, H.T., Lyamuya, E.F., Loeser, H., Mkony, C.A., O’Sullivan, P., Kaaya, E.E., and Macfarlane, S.B. (2012) Commentary: Partnering in education for health: Muhimbili University of Health and Allied Sciences and the University of California San Francisco. J Public Health Pol 33; S1, S13-S22. 13. Kwesigabo, G.,Mwangu,M.A., Kakoko, D.C., Warriner, I., Mkony, C.A., Killewo, J.,Macfarlane, S.B.,Kaaya, E.E., and Freeman, P. (2012) Tanzania’s health system and workforce crisis: context for educating health professionals. J Public Health Pol 33; S1, S35-S44. D. Recent research support Fogarty/ National Institutes of Health (with Dartmouth University) 08/01/2013 - 12/31/2016 “Developing the OSP at Muhimbili University: A North-South Training Collaborative” Role: UCSF PI, Co-investigator UCSF technical services agreement with the Aga Khan University (AKU) 10/1/2012 – 03/31/2014 “Integrated Primary Health Care – Kaloleni District” Supporting the development for and academic research around the Integrated Primary Health Care project. Role: PI ITECH 10/01/2012 - 03/31/2013 “Faculty and curriculum development at six universities in Ethiopia”. Subcontract with UW, flow-thru from HRSA. Running workshops on faculty development. Role: PI The California Endowment 07/01/2007 - 06/30/2008 “The 2007/2008 Forum on Migration and Health” Describing research needs in the area of migration and health across the California-Mexico border. Role: PI California HealthCare Foundation 07-1264 10/01/2007 - 11/30/2007 “The 2007/2008 Global Health Sciences Forum on Migration and Health” Describing the research needs in the area of migration and health across the California-Mexico border. Role: PI Rockefeller Foundation 05/01/2007 - 07/31/2007 “Increasing access to surgical services in resource-constrained settings in Africa” Support for a meeting around increasing access to surgical services. Role: PI

Program Director/Principal Investigator (Last, First, Middle): Martin, Jeffrey N, MD, MPH

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Jeffrey N Martin, MD, MPH Professor of Epidemiology and Biostatistics, eRA COMMONS USER NAME University of California, San Francisco (UCSF) jmartinucsf Attending Physician, San Francisco General Hospital

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Johns Hopkins University; Baltimore, Maryland BA 1979-83 Biology University of Pennsylvania; Philadelphia MD 1983-88 Medicine University of California, San Francisco 1988-89 Medicine - Internship University of California, San Francisco 1989-91 Medicine - Residency University of California, San Francisco 1991-92 Medicine - Chief Residency University of California, Berkeley MPH 1992-93 Epidemiology University of California, San Francisco 1993-97 Infectious Diseases - Fellowship University of California, San Francisco 1993-97 AIDS Prevention - Fellowship

A. Personal Statement

The goal of the proposed project is to strengthen the consortium between the University of California, San Francisco (UCSF) and the Infectious Diseases Institute (IDI, of the Makerere School of Medicine in Uganda) focused on research career development and performance of research related to the prevention and early detection of infection-related HIV-associated malignancies. We will bolster the overall platform for career development in clinical and translational research at the IDI and provide specifically for the support of emerging Ugandan principal investigators who will lead three different research projects. I will be Co-Principal Investigator (PI) of the consortium along with Dr. Andrew Kambugu, Head of the Department of Research at the IDI. I will direct the Administrative Core, co-direct the Mentoring Core, and mentor Dr. Aggrey Semeere as he leads Research Project 3 on the occurrence of Kaposi’s sarcoma amongst patients on antiretroviral therapy. My qualifications for this project include both theoretical background and practical experience. In addition to my formal training in epidemiology, I am Director of the UCSF Training in Clinical Research (TICR) Program, which provides didactic training (in both certificate and graduate programs) in clinical, epidemiologic, and translational research methods to professional students, clinical residents, post-doctoral fellows, and junior faculty members. This includes being Director of the Advanced Training in Clinical Research Certificate Program, Director of the Master’s Degree Program in Clinical Research, and a member of the Executive Committee of the Doctoral Program in Epidemiology and Translational Science. Scholars from all four professional schools at UCSF as well as the graduate division are served by the program, which is part of the UCSF NIH-sponsored Clinical and Translational Science Award (CTSA). The TICR Program includes 33 different courses covering an array of topics from “laboratory to human subjects” translational research, conventional clinical research, and “evidence to practice” translational research. I am the course director of Epidemiologic Methods, one of the program’s foundational courses in research methods. On a practical level, I have extensive experience in both observational and experimental research in both the U.S. and Africa. In the U.S., I am Co-Director of the Population and Clinical Sciences Core of the UCSF Center for AIDS Research (CFAR), which manages the UCSF SCOPE cohort. In Africa, I am the PI for the recently completed R01 CA119903 (a randomized trial for the therapy of Kaposi’s sarcoma in Africa); lead investigator for the Kaposi’s sarcoma epidemiologic studies of the East Africa IeDEA consortium (U01 AI069911); and Director of the Data Coordinating Center for the Uganda AIDS Rural Treatment Outcomes (UARTO) Cohort. Relevant to the current application, I am the PI for D43 CA153717, a training grant for research capacity-building in HIV- associated malignancies in Uganda, for which UCSF has been partnering for the past 3 years with the IDI. This award has supported the training of Ugandan community providers, pathologists, and emerging Principal Investigators, all of whom will play roles in the current application. In all of this work, I have had broad practical experience with study design, measurement development, study recruitment and retention, data collection, quality enhancement, data reporting, biostatistical analysis, manuscript preparation and financial management. PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator: Martin, Jeffrey N, MD, MPH

B. Positions and Honors Principal Positions Held: 1997-2003 Assistant Professor of Epidemiology and Biostatistics, UCSF 2003-2009 Associate Professor of Epidemiology and Biostatistics, UCSF 2009-present Professor of Epidemiology and Biostatistics, UCSF 1997-present Attending Physician, San Francisco General Hospital 1997-1999 Co-Director, Advanced Training in Clinical Research (ATCR) Program, UCSF 2000-2006 Co-Director, NIH K30-sponsored Training in Clinical Research (TICR) Program, UCSF 2000-present Director, Advanced Training in Clinical Research (ATCR) Certificate Program, UCSF 2001-present Director, Master’s Degree Graduate Program in Clinical Research, UCSF 2006-present Director, NIH CTSA-sponsored Training in Clinical Research (TICR) Graduate Program, UCSF

Honors and Awards: 1982 Phi Beta Kappa 1988 Alpha Omega Alpha 1988 Merck Manual Award, University of Pennsylvania School of Medicine 1989 Diplomate, National Board of Medical Examiners 1991 Diplomate, American Board of Internal Medicine 1996 Diplomate, American Board of Internal Medicine, Subspecialty in Infectious Diseases 1998 New Investigator Award, UCSF Center for AIDS Research (CFAR) 2009 Stephen B. Hulley Award for Excellence in Instruction in Methods of Clinical Research at UCSF

C. Selected Peer-reviewed Publications (selected out of 253) Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, and Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. New England Journal of Medicine 338:948-954, 1998. Martin JN, Amad Z, Cossen C, Lam PK, Kedes DH, Page-Shafer K, Osmond DH, and Forghani B. Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies. Journal of Clinical Microbiology 38:696-701, 2000. Martin JN and Osmond DH. Determining specific sexual practices associated with human herpesvirus 8 transmission. American Journal of Epidemiology 151:225-229, 2000. Brander C, O’Connor P, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, and Scadden DT. Definition of an optimal CTL epitope in the latently expressed KSHV kaposin protein. Journal of Infectious Diseases 184:119–126, 2001. Osmond DH, Buchbinder S, Cheng A, Graves A, Vittinghoff E, Forghani B, and Martin JN. Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men before and during the HIV epidemic. Journal of the American Medical Association (JAMA) 287: 221-225, 2002. Martin JN. Diagnosis and epidemiology of human herpesvirus 8 infection. Seminars in Hematology 40:133- 142, 2003. Martin JN. Moving towards clarity on two fronts in the epidemiology of Kaposi sarcoma-associated herpesvirus infection. Journal of Infectious Diseases 196:173-175, 2007. Hsue PY, Deeks SG, Farah HH, Waters DD, Palav S, Ahmed SY, Schnell A, Ellman AB, Huang L, Dollard SC, and Martin JN. Role of HIV and HHV-8 infection in pulmonary arterial hypertension. AIDS 22:825-833, 2008. PMCID: PMC2711076. Geng EH, Emenyonu N, Bwana BM, Glidden DV, and Martin JN. Sampling-based approach to determine outcomes of patients lost to follow-up in antiretroviral therapy scale-up programs in Africa. Journal of the American Medical Association (JAMA) 300:506-507, 2008. Phillips AM, Graves-Jones A, Osmond DH, Pollack LM, Catania JA, and Martin JN. Awareness of Kaposi’s sarcoma-associated herpesvirus among men who have sex with men. Sexually Transmitted Diseases 35:1011-1014, 2008. PMCID: 2593118. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, and Martin JN. Kaposi’s sarcoma-associated herpesvirus seroprevalence

PHS 398/2590 (Rev.06/09) Page Continuation Format Page Program Director/Principal Investigator: Martin, Jeffrey N, MD, MPH

among population-based samples of children in South Africa and Uganda: Evidence for at least two epidemiologic patterns of KSHV transmission in Africa. Journal of Infectious Diseases 200:430-438, 2009. Dollard SC, Graves-Jones AM, Butler LM, Mermin JH, Chidzonga M, Chipato T, Shiboski CH, Padian NS, Brander C, Kiepiela P, Mosam A, Hladik W, and Martin JN. Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: Insights on the origin of the “KS belt”. International Journal of Cancer 127:2395-401, 2010. PMCID: 2895015 Hunt PW, Cao HL, Muzoora C, Ssewanyana I, Bennett J, Emenyonu N, Kembabazi A, Neilands TB, Bangsberg DR, Deeks SG, Martin JN. Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS 25:2123-2131, 2011. PMCID: 3480326. Semeere AS, Busakhala N, and Martin JN. Impact of antiretroviral therapy on the incidence of Kaposi's sarcoma in resource-rich and resource-limited settings. Current Opinion in Oncology 24:522-530, 2012. PMCID: 3418488 Unemori PA, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, Effros RB, Dock J, Dollard SG, Deeks SG, Martin JN, Maurer TS. Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated human immunodeficiency virus infection. AIDS 27:1735-42, 2013. PMID: 23435301.

D. Research Support

Ongoing Research

D43 CA153717 (Martin, PI) 9/01/10 - 8/31/14 NIH-NCI Uganda-UCSF Research Training Program in HIV-Associated Malignancies

The major goal of this project is to provide training to Ugandan health care providers and emerging scientists related to promoting early diagnosis of HIV-related Kaposi’s sarcoma in Uganda as well as training related to studying the epidemiology, clinical course, and treatment of Kaposi’s sarcoma in the antiretroviral therapy era. Role: Principal Investigator

U01 AI069911 (Yiannoutsos, PI; Martin, UCSF PI) 8/1/11 – 7/31/16 NIH-NIAID East Africa Consortium of International Epidemiologic Databases to Evaluate AIDS (IeDEA)

The major goal of this project is to develop a large cohort in East Africa to evaluate the epidemiology and response to antiretroviral therapy among HIV-infected individuals in resource-limited settings. Data from East Africa are subsequently shared with the larger IeDEA network in 6 other regions worldwide. Role: Principal Investigator of UCSF Subcontract

U01 AI069918 (Moore, PI; Martin, UCSF PI) 7/1/11 – 6/30/16 NIH-NIAID North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)

The major goal of this project is to develop a large consortium of cohorts related to HIV/AIDS in North America to evaluate questions related to natural history and response to therapy. Data from N. America are subsequently shared with the larger IeDEA network in 6 other regions worldwide. Role: Principal Investigator of UCSF Subcontract

UL1 RR024131 (Johnston, PI) 7/1/11 - 6/30/16 NIH-NCRR Clinical and Translational Sciences Institute (CTSI) PHS 398/2590 (Rev.06/09) Page Continuation Format Page Program Director/Principal Investigator: Martin, Jeffrey N, MD, MPH

The major goal of this project is to develop a comprehensive, integrated academic home that promotes research and education in clinical and translational science at UCSF. Role: Co-Investigator; Director, Clinical Research Training Program

P30 AI27763 (Volberding, PI) 9/1/12 – 8/31/17 NIH-NIAID Center for AIDS Research

The major goals of this Center grant are devoted to supporting a wide array of translational studies (basic science to clinical application) in the field of HIV/AIDS. Role: Co-Investigator; Co-Director, Population and Clinical Sciences Core

R01 MH054097 (Bangsberg, PI) 7/1/10 – 3/31/15 NIH-NIMH Novel Approaches to Monitoring and Utilizing Adherence to HIV Therapy in Africa

The major goal of this project is to evaluate novel wireless real-time assessment of adherence to antiretroviral therapy in Africa in order to better understand the manifestations of short-term treatment interruptions as well as to potentially supplant plasma HIV RNA testing. Role: Principal Investigator of UCSF Subcontract

Completed Research

R01 CA119903 (Martin, PI) 9/30/05 - 7/31/12 NIH-NCI Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa

The major goal of this project is to evaluate the relative effectiveness of protease inhibitor- based antiretroviral therapy versus protease inhibitor-sparing antiretroviral therapy in the treatment of AIDS-related Kaposi’s sarcoma in Africa. Role: Principal Investigator

K30 RR22257 (Martin, PI) 7/1/05 - 9/30/06 (converted to NIH-NCRR NIH CTSA mechanism) Clinical Research Curriculum Award (K30)

The major goal of this project is to develop a clinical research training program for physician scientists. Role: Principal Investigator

PHS 398/2590 (Rev.06/09) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle):

NAME POSITION TITLE Wendy Barbara Max Professor eRA COMMONS USER NAME wenbmax EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Stanford University, Stanford, CA BA 1976 History, Economics University of Colorado, Boulder, CO MA 1981 Economics University of Colorado, Boulder, CO Ph.D. 1983 Economics

A. Positions and Honors 1976 Graduated from Stanford University with Honors 1979-80 Health Policy Analyst, Colorado Department of Health, Denver, CO 1980-81 Research Associate, Solar Energy Research Institute, Golden, CO 1982-83 Teaching Assistant, Univ. of CO, Boulder, CO 1983-91 Assistant Professor, CA State University, Hayward 1991-94 Assistant Adjunct Professor, Institute for Health & Aging, UCSF 1994-99 Associate Adjunct Professor, Institute for Health & Aging, UCSF 1999-present Co-Director, Institute for Health & Aging, UCSF 1999-present Professor, Department of Social and Behavioral Sciences, UCSF 2001-06 Honorary Visiting Professorship, Beijing Normal University, Beijing, People’s Republic of China 2010 30th Helen Nahm Distinguished Research Award, School of Nursing, UCSF 2014 Harold S. Luft Award for Mentoring in Health Services and Health Policy Research

B. Selected Papers and Publications

2009 John R, Sung H-Y, Max W. Economic cost of tobacco use in India, 2004. Tobacco Control 18: 138-143. 2009 Max W, Sung HY, Shi Y. Who is exposed to secondhand smoke? Self-reported and serum cotinine measured exposure in the U.S., 1999-2006. International Journal of Environmental Research and Public Health. Available online at http://www.mdpi.com/1660-4601/6/5/1633 2010 Max W, Sung HY, Tucker LY, Stark B. The disproportionate cost of smoking for African Americans in California. AJPH 100 (1): 152-158. Published first online at www.ajph.org, First Look. 2010 Miller LS, Max W, Sung H-Y, Rice DP, Zaretsky, M. Evaluation of the economic impact of California’s tobacco control program: A dynamic model approach. Tobacco Control 10 (Suppl 1): i68-i76. Doi: 10.1136/tc.2008.029421. 2011 Max W, Sung HY, Tucker LY, Stark B. The Cost of smoking for California's Hispanic Community. Nicotine & Tobacco Research 13(4): 248-254. Advance Access published January 17, 2011 doi: 10.1093/ntr/ntq245 2011 John R, Sung HY, Max W, Ross H. Counting 15 million more poor in India, thanks to tobacco. Tobacco Control 2011;20:349-352 doi:10.1136/tc.2010.040089. TC Online First, published on February 3, 2011 as 10.1136/tc.2010.040089 PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): 2011 Dicker RA, Lopez DS, Pepper M, Crane L, Max W. Cost-driven injury prevention: Creating an innovative plan to save lives with limited resources. Journal of Trauma 70(4): 985-990, 2011. doi: 10/1097/TA.ob013e318210f5b1.

2012 Max W, Sung HY, Lightwood J. The impact of changes in tobacco control funding on healthcare expenditures in California, 2012-2016. Tobacco Control. TC Online First, published January 17, 2012 as 10.1136/tobaccocontrol-2011-050130. 2012 Max W, Sung HY, Shi Y. Exposure to secondhand smoke at home and in the workplace in California. Public Health Reports, 127:81-88. 2012 Max W, Sung HY, Shi Y. Deaths from secondhand smoke exposure in the United States: economic implications. Am J Public Health. 2012 Nov;102(11):2173-80. doi: 10.2105/AJPH.2012.300805. Epub 2012 Sep 20 2012 Max W, Sung HY, Shi Y. Attention deficit hyperactivity disorder among children exposed to secondhand smoke A logistic regression analysis of secondary data. International Journal of Nursing Studies, Published online first 26-OCT-2012 DOI: 10.1016/j.ijnurstu.2012.10.002 2014 Yao T, Huang J, Sung HY, Ong M, Mao Z, Jiang Y, Fong G, Max W. Who purchases cigarettes from cheaper sources in China? Findings from the ITC China Survey. Tob Control;23:i97–i101. doi:10.1136/tobaccocontrol-2013-051040

2014 Van Kempen BJH, Ferket BS, Hofman A, Franco O, Krestin GP, Steyerberg EW, Max W, Hunink M, Fleischmann KE. Comparing the cost-effectiveness of four novel risk markers for screening asymptomatic individuals to prevent cardiovascular disease (CVD) in the US population. PLOS ONE 19(2):e88312.

2014 Max W, Sung H-Y, Shi Y. The cost of secondhand smoke exposure at home in California. Tob Control. TC Online First, published on February 5, 2014 as 10.1136/tobaccocontrol-2013-051253

2014 Yao T, Huang J, Sung HY, Ong M, Mao, Z, Jiang Y, Fong G, Max W. Determinants of smoking-induced deprivation in China: Findings from the ITC China Survey. Tob Control, forthcoming.

C. Research Support

ACTIVE

20CA-0102 Max, W. (PI) 8/1/11-7/31/14 California Tobacco-Related Disease Research Program The Cost of Smoking for California’s 58 Counties This study will develop estimates of the cost of smoking for each of California's 58 counties, including costs of both active smoking and secondhand smoke exposure. Estimates will be made of smoking-attributable healthcare costs, time lost from activities, and the value of lives lost prematurely due to smoking-related illness. Role: PI

Kohatsu, N. (PI) 11/16/11-9/12/16 Centers for Medicare & Medicaid Services Medicaid Incentives for the Prevention of Chronic Disease This project will implement an incentive program to reduce smoking prevalence among all Medi-Cal beneficiaries with an emphasis on outreach to those at high risk due to diabetes and other chronic conditions. The primary intervention will be the California Smokers‟ Helpline. The primary outreach effort will be guided and implemented by the California Diabetes Program. The economics team will measure the cost-

PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): effectiveness of the helpline program outreach activities and also the relative cost-effectiveness of alternative forms of outreach. We will also analyze the relative cost-effectiveness of different incentives to get Helpline callers to quit smoking. We will then use cost of smoking models and the CHD Policy Model to evaluation the short- and long-term impact of smoking cessation on MediCal costs, particularly those related to diabetes and other chronic illness. Role: Co-Investigator (leader of economic analysis team).

1R21DC011510-01 Wallhagen, M. (PI) 04/01/11 – 03/31/16 NIH, National Institute on Aging Primary Care Intervention Promoting Hearing Health Care Service Access and Use Hearing loss is one of the most common problems experienced by older adults, significantly impacts the well- being of these older adults and their families, and impacts society by preventing them from continuing to remain engaged in community activities and potentially contributing to cognitive decline. This minimizes their potential to effectively adapt to hearing aids or obtain other nonmedical treatment appropriate to their hearing health needs. This project specifically addresses these issues by developing, refining and testing a time-efficient,effective, primary care based screening and educational intervention protocol that will promote subsequent access to and successful use of hearing health care services. Role: Co-Investigator

1 R01 AG042526 Johnson, J. (PI) 8/1/12-7/31/17 NIH, National Institute on Aging Community Choirs to Promote Healthy Aging and Independence of Older Adults This study will examine the influence of participation in community-based choral programs on primary and secondary health outcomes among elderly patients. The study will evaluate the efficacy of thecommunity choir program on health and well-being and evaluate program costs. Role: Co-Investigator

22RT-0120 Max, w. (PI) 08/01/13-01/31/16 California Tobacco-Related Disease Research Program Health and Economic Toll of Tobacco on CA's LGBT Community The objective of this study is to assess the health, healthcare utilization, and economic impacts of smoking in California's lesbian, gay, bisexual, and transgender (LGBT) community. Role: Principal Investigator

22RT-0112 Sung, H-Y. (PI) 08/01/13-07/31/16 . California Tobacco-Related Disease Research Program Economic Impact of Tobacco Taxes in African American Community This study will evaluate the impact of tobacco tax increases on cigarette smoking behavior and quitting behavior for African Americans, and assess whether tobacco tax increases are regressive to the African American community in California. Role: Co- Investigator

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

NAME POSITION TITLE Suellen Miller, Ph.D., R.N. C.N.M., M.H.A Professor eRA COMMONS USER NAME SUELLEN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION (if MM/YY FIELD OF STUDY applicable) American University, Washington, DC BA 05/69 English Montgomery College, Takoma Park, MD AA 05/74 Nursing Meharry Medical School, Nashville, TN CNM 05/77 Nurse-Midwifery Health Services Antioch University West, San Francisco, CA MA 05/82 Administration Family Health University of California-San Francisco, San PhD 05/94 Francisco, CA Care/Nursing Advanced Biostatistics & University of California-San Francisco, San Certificate 05/96 Francisco, CA Epidemiology

NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.

A. Personal Statement I am Director of the Safe Motherhood Program at the Bixby Center for Global Reproductive Health and Professor of the Dept. of Obstetrics Gynecology & Reproductive Sciences (OGRS, and Principal Investigator of NIH/NICHD R01 (HD053129-01A1 with a site in Zimbabwe). I have extensive experience in international reproductive health in a variety of countries and cultures, particularly Sub-Saharan Africa, including Nigeria, Uganda, Zambia, and Zimbabwe, and other countries outside the region, such as Mexico, India and Bangladesh. I am the UCSF faculty member who is senior advisor/investigator on the UZ-UCSF Clinical Trials Unit,, NIAID/NIH 5U01AI069436-02 , and a member of the UZ-UCSF Clinical Trials Unit Executive Committee. I travel to Zimbabwe at least twice a year for CTU activities and to monitor my R01.

Examples of my recent mentoring of fellows/junior faculty include: Dr. Janet Turan, in her NIH- 1K01MH081777 NIMH, K-award in 2012 as junior faculty member in UCSF’s department of OGRS with whom I was co-investigator on her research on the effects of HIV epidemic on maternal health services delivery. Dr. Amy Stenson, MD, MPH, supported by an NIH “Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) fellowship worked with me in 2011 on my R01 HD053129-01A1 NIH/NICHD, Non-pneumatic Anti- Shock Garment for Obstetrical Hemorrhage. I was awarded an American Recovery and Reinvestment Act of 2009 (ARRA) supplement supporting a new PhD, Dr. Sheri Lippman (3R01HD053129-03S1). Recent fellows include: Dr. Catherine Todd, assistant professor in the Division of International Health & Cross-Cultural Medicine at UC San Diego in her NIH K study (K01TW007408-04) of peri-natal infections among pregnant women in Afghanistan. Dr. Sadia Haider, a Post Doctoral Family Planning Fellow in the School of Medicine at UCSF, was also mentored by me in her study of near-miss maternal mortality in Afghanistan, and a Diversity Scholar, Ms. Stephanie Boarden, 3R01HD053129-01A1S.

B. Positions and Honors Positions: 1994-96 Postdoctoral Research Fellow, Institute for Health Policy Studies, School of Medicine, University of California, San Francisco 1997-00 Adjunct Assistant Professor, School of Public Health, University of California, Berkeley and Supervisor of Public Health Practice, School of Public Health, University of California, Berkeley 2000-02 Director, Expanding Contraceptive Choice Program, Population Council 2002-07 Adjunct Assistant Professor, Women’s Global Health Imperative, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA and Director of Safe Motherhood Program, University of California, San Francisco, CA and Adjunct Assistant Professor, School of Public Health, Maternal and Child Health Program, University of California, Berkeley 2007-11 Associate Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, Director of Safe Motherhood Program, Bixby Center for Global Reproductive Health. Adjunct Associate Professor, School of Public Health, Maternal and Child Health Program, University of California, Berkeley 2011-present Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, Director of Safe Motherhood Program, Bixby Center for Global Reproductive Health. Associate Professor, School of Public Health, Maternal and Child Health Program, University of California, Berkeley

Honors: 1991-93 Scholastic Achievement and Potential for Leadership, University of California Regent's Graduate Fellowship Award, University of California, San Francisco 1991-95 National Research Service Award (NRSA), Pre-Doctoral Fellowship, National Center for Nursing Research, National Institutes of Health. 1993 Outstanding Service Award for Service on the Nurse Midwifery Advisory Committee, Board of Registered Nursing 1995 Distinguished Dissertation Award, School of Nursing, University of California, San Francisco 2005 First Place: Royal College of Obstetrics and Gynecology Poster Presentation, 6th Scientific Meeting, Cairo, Egypt 2006 Winner, American College of Nurse Midwives Notable Book, 2006: A Book for Midwives 2006 Women’s Global Action Network, Royal Hashemite Court, Queen Rania Abdullah, Jordan 2006 Winner, Society of Medical Anthropology, Polgar Prize for: Challenge of Cross-Cultural Clinical Trials Research: Case Report from the Tibetan Autonomous Region, People’s Republic of China. Medical Anthropology Quarterly, 19 (3): 267-89. (PMC16222962) 2008 Recipient, UCSF RAP (Resource Allocation Program) Flexible Mini-Sabbatical Award. To further focus efforts more intensively on current NASG research. Effective 7/1/08 – 6/20/09 2011 Winner, People’s Choice Award for: Project mMitra: Voice messaging and animation service to improve MCH information access in rural India. Presented at: Saving Lives at Birth: A Grand Challenge for Development, sponsored by the Gates Foundation, USAID, World Bank, Government of Norway and Grand Challenges Canada.

C. Selected Peer-reviewed Publications

1. Butrick E; Penn, A; Itakura, K; Mkumba, G; Winter, K; Amafumba, R; Miller, S. Access to transport for women with hypovolemic shock differs according to weeks of pregnancy (2014) IJGO 2. Curtis, M; El Ayadi, A; Mkumba, G; Butrick, E; Leech, A; Geissler, J; Miller, S. Association Between Severe Obstetric Hemorrhage and HIV Status. (2014) IJGO; 125(1). 3. Sutherland, T; Downing, J; Miller, S; Bishai, D; Butrick, E; Fathalla, M; Mourad-Youssif, M; Ojengbede, O; Nsima, D; Kahn, J. Use of the non-pneumatic anti-shock garment (NASG) for life-threatening obstetric hemorrhage: A cost-effectiveness analysis in Egypt and Nigeria. 2013 PLoS ONE, 8(4): e62282. doi:10.1371/journal.pone.0062282

4. El Ayadi, A., Raifman, S., Jega, F., Butrick, E., Ojo, Y., Geller, S., Miller, S. Comorbidities and Lack of Blood Transfusion May Negatively Affect Maternal Outcomes of Women with Obstetric Hemorrhage treated with NASG.2013 PLoS ONE, 8(8): e70446. 5. El Ayadi, A; Butrick, E; Geissler, J; Miller, S. Combined Analysis of the Effect of the Non-pneumatic Anti- Shock Garment on Mortality from Hypovolemic Shock Secondary to Obstetric Hemorrhage. BMC Pregnancy & Childbirth; 13(208). 6. Miller, S., Fathalla, M., Ojengbede, O., Camlin, C.,Mourad-Youssif, M., Morhason-Bello, IO, Obstetric Hemorrhage and Shock Management: Using the Low Technology Non-pneumatic Anti-Shock Garment in Nigerian and Egyptian Tertiary Care Facilities. 2010 BMC Pregnancy Childbirth 2010, 10:64. PMCID: PMC2966449. 7. Berdichevsky, K., Tucker, C., Martinez, Miller, S. Acceptance of a New Technology for Management of Obstetric Hemorrhage: A Qualitative Study from Rural Mexico. Health Care Women Int. May 2010, 31(5):444-57. PMCID: PMC2865407. 8. Miller, S, Hamza, S, Bray E, Gipson R, Nada, K, Fathalla, M., Mourad, M. et al. First Aid for Obstetrical Hemorrhage: The Pilot Study of the Non-pneumatic Anti-Shock Garment (NASG) in Egypt. British Journal of Obstetrics & Gyneacology, 113(4): p. 424-9, 2006. 9. Haider, S., Todd, C., Ahmadzai, M., Rahimi, S., Azfar, P., Morris, J., Miller, S. Childbearing and Contraceptive Decision-Making amongst Afghan Men and Women: A Qualitative Analysis. Health Care Women Int 2009, 30(10):935-53. PMID: 19742366. 10. Miller, S., Turan, JM, Dau, K., Fathalla M., Mourad M., Sutherland, T., Hamza, S. et al. Decreasing Maternal Mortality from Hypovolemic Shock in Low Resource Settings: the Non-pneumatic Anti-Shock Garment (NASG). Global Public Health Journal, 2(2);110-24, 2007. 11. Stenson, A. Kapungu, C., Geller, S., Miller, S. Navigating the Challenges of Global Reproductive Health Research. 2010 J Womens Health, 19(11): 2101-2107, 2010. PMCID: PMC3004132. 12. Miller S., Sloan, N., Langer, A., Fikree, F., Winikoff, B. Where is the E in MCH? Evidence-based Interventions to Prevent Maternal Mortality in Developing Countries. , Journal of Midwifery and Women’s Health, 8(1), 10-18, 2003. 13. Miller S., Cordero, M, Coleman, AL, Figueroa, J, Brita-Anderson, S, Dabash, R, Calderone, V, Cáceres, F, Fernandez, AJ, Nunez, M. Quality of Care in Institutionalized Deliveries: The Paradox of the Dominican Republic. International Journal of Gynecology and Obstetrics, 82(2003): 89-103, 2003. 14. Klein S, Miller, S, Thompson, F. A Book for Midwives, 3rd Edition. Berkeley, CA: Hesperian Foundation, 2002, 2005, 2009. Winner, American College of Nurse Midwives, 2006 Book Award. 15. Adams, V, Miller, S, Craig, S, Samen, A, Nyima, Lhakpen, Sonam, Droyoung, Varner, M. The Challenge of Cross-Cultural Clinical Trials Research: Case Report from the Tibetan Autonomous Region, People’s Republic of China. Medical Anthropology Quarterly, 19(3), 267-289. (PMC16222962) Winner Polgar Prize, best article of the year, Society for Medical Anthropology, 2005. 16. Miller, S., Le, P., Craig, S., Adams, A., Tudor, C., Sonam, Nyima, Droyoung, Tshomo, M. Lhakpen, Varner, M. How to Make Consent Informed: Possible Lessons from Tibet. IRB: Ethics & Human Research. 2007 29(6): 7-14, 2007. PMCID: PMC2789738. 17. Geller, S, Adams, MG, Miller, S, A Continuum of Care Model for Postpartum Hemorrhage, International Journal of Fertility, 52(2-3), 97-105, 2007. PMID: 18320868. 18. Turan, J. M., Miller, S., Bukusi, E. A., Sande, J. and Cohen, C. R. 2008 HIV/AIDS and maternity care in Kenya: how fears of stigma and discrimination affect uptake and provision of labor and delivery services, AIDS Care, 2008 20:8,938 – 45. PMCID: PMC2556865. 19. Miller, S., Fathalla, M., Ojengbede, O., Camlin, C., Mourad-Youssif, M., Morhason-Bello, IO, Obstetric Hemorrhage and Shock Management: Using the Low Technology Non-pneumatic Anti-Shock Garment in Nigerian and Egyptian Tertiary Care Facilities. 2010 BMC Pregnancy Childbirth 2010, 10:64

D. Research Support

Ongoing Research Support

Clinton Health Access Initiative Miller (PI) 9/2013-8?2014 In collaboration with the Emergency Ultrasound Department, UCSF, to study the reduction in blood flow among normal healthy female volunteers who are placed in an anti shock garment.

Gynuity Health Projects Geller (PI) 1/1/2011-7/31/2013 Prime Sponsor: Bill and Melinda Gates Foundation Two community strategies comparing use of misoprostol for early treatment/secondary prevention to primary prevention for postpartum hemorrhage: a randomized cluster non-inferiority study in Bijapur district, Karnataka, India This study will compare universal prophylactic treatment with “early treatment/secondary prevention” to inform service delivery programs on clinical outcomes, program feasibility, cost, and acceptability. Role: UCSF PI

NIAID/NIH 5U01AI069436-02 Chirenje (PI) 3/1/2007-11/30/2013 Renewed 11/2013-10/2020 UZ-UCSF Clinical Trials Unit (CTU) for HIV/AIDS Research Clinical trials unit for HIV prevention and treatment studies in Zimbabwe. Role: Senior Advisor

Completed Research Support

NIH/NICHD R01HD053129-01A1 Miller (PI) 6/1/2007-5/31/2013 Non-Pneumatic Anti-Shock Garment for Obstetrical Hemorrhage Randomized cluster trial to test the effectiveness of the NASG as first aid hemorrhage and shock management to: 1) reduce the incidence of maternal mortality, 2) reduce the incidence of severe acute maternal morbidity, 3) reduce the incidence of emergency hysterectomies, and 4) reduce the time to recovery from hemorrhagic shock. Role: PI

48541, Bill and Melinda Gates Foundation Miller (PI) 10/15/2007-10/31/2013 Cluster Randomized Trial of the NASG in Zambia and Zimbabwe The purpose of the grant is to demonstrate the efficacy of the non-pneumatic anti-shock (NASG) garment among women in Zambia and Zimbabwe. Role: PI

07-90033-000-UNA-01-UCSF, Pathfinder International Prime: John T. And Catherine D. MacArthur Foundation Miller (PI) 11/1/2007-5/31/2012 A Continuum of Care for Post Partum Hemmorhage (PPH) in India and Nigeria Implementation project to test a package of interventions to prevent, identify, manage, and to refer/transport patients with PPH from the lowest level/home to appropriate facilities. Role: PI

NIH 3R01HD053129-03S1 Miller (PI) 6/1/2009-6/28/2012 Administrative Supplement under the American Recovery and Reinvestment Act (ARRA) of 2009 for the NASG R01 Study Role: PI

John D. and Catherine T. MacArthur Foundation Miller (PI) 12/1/2008-11/30/2010 Analysis and Dissemination for Findings of NASG Trials in Nigeria and Egypt Role: PI

John D. and Catherine T. MacArthur Foundation Kastrinakis (PI) 12/1/2008-11/30/2010 Millennium Development Villages, Columbia University An implementation project targeted at improving maternal health with accepted interventions in model development villages.

Program Director/Principal Investigator: Dominic Montagu

NAME POSITION TITLE Montagu, Dominic, Duncan Associate Adjunct Professor eRA COMMONS USER NAME (credential, e.g., agency login)

A. Personal Statement While a visiting faculty at UC Berkeley I created what I believe to be the first course ever on issues of private healthcare in low- and middle-income countries. I have been lead faculty in the joint World Bank Institute / Asian Network on Health System Strengthening course on the private sector each year for the past three years. In that capacity I've led the development of overall course content, writing, commissioning, and editing of background papers, and approved all course materials and presentations. I have also mentored colleagues from Asian Institutes, supporting them as they become increasingly proficient in the material on private sector policy. Over the course of the three years this course has transitioned from being primarily taught by myself and other experts from the World Bank, to being about 60% taught by Asian faculty. The collaborations with these faculty, which continues, is a strong foundation upon which to base the proposed joint-training program. B. Positions and Honors Principals Positions Held 1990 1992 Architectes Sans Frontières. Ho Chi Chief Architect Minh City, Vietnam 1996 1997 American Friends Service Country Director Committee, Hanoi, Vietnam 1997 1998 Population Council, Hanoi, Vietnam Country Advisor 2002 2003 UC Berkeley School of Public Health, Specialist CA Researcher 2002 2004 UC Berkeley School of Public Health, Lecturer CA 2003 2012 University of California, San Assistant Adjunct Epidemiology and Francisco, CA Professor Biostatistics 2012 present University of California, San Associate Adjunct Epidemiology and Francisco, CA Professor Biostatistics

Other Positions Held Concurrently 2004 2011 UC Berkeley School of Public Health, Visiting Lecturer / CA Faculty 2005 2007 World Health Organization, Geneva Secretariat, NSS

PHS 398/2590 (Rev. 06/09) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator: Dominic Montagu

Policy Group 2009 2011 Marie Stopes International, London Research Advisor

Honors Awards 1993 Southeast Asian Traveling Research Fellowships Berkeley 1994 Foreign Language and Area Studies (FLAS) Fellowship 1995 Foreign Language and Area Studies (FLAS) Fellowship 1998 Bixby Fellow for Population & Family Planning 1999 Bixby Fellow for Population & Family Planning 1999 Federal (DHHS) MCH Economic Analysis Traineeship 2000 Federal (DHHS) MCH Economic Analysis Traineeship 2000 Bixby Fellow for Population & Family Planning 2001 Bixby Fellow for Population & Family Planning 2002 Gary K. Stewart Memorial Prize

Memberships 2002 present International Health Economics Association 2012 present Health Systems Global

Service to Professional Organizations C. Selected Peer-Reviewed Publications 1. Montagu D. Franchising of health services in low-income countries. Health Policy Plan. 2002 Jun; 17(2):121-30. 2. Montagu D, Elzinga G. Innovations in access to TB and HIV/AIDS care in sub-Saharan Africa: dynamic engagement of the private sector. Appl Health Econ Health Policy. 2003; 2(4):175-80. 3. Prata N, Montagu D, Jefferys E. Private sector, human resources and health franchising in Africa. Bull World Health Organ. 2005 Apr; 83(4):274-9. 4. Decker M, Montagu D. Reaching youth through franchise clinics: assessment of Kenyan private sector involvement in youth services. J Adolesc Health. 2007 Mar; 40(3):280-2. 5. Montagu D, Graff M. Equity and financing for sexual and reproductive health service delivery: current innovations. J Fam Plann Reprod Health Care. 2009 Jul; 35(3):145-9. 6. Lowe R, and Montagu D. Legislation, Regulation, and Consolidation in the Retail Pharmacy Sector in Low-Income Countries. Southern Medical Review. 2009 2; 2:35-44 7. Montagu D, Yamey G, Visconti A, Harding A, Yoong J. Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data. PLoS One. 2011; 6(2):e17155. 8. Montagu D, Yamey G. Pay-for-performance and the Millennium Development Goals. Lancet. 2011 Apr 23; 377(9775):1383-5. 9. Forsberg BC, Montagu D, Sundewall J. Moving towards in-depth knowledge on the private health sector in low- and middle-income countries. Health Policy Plan. 2011 Jul; 26 Suppl 1:i1-3. 10. Aung T, Khin HSS, McFarland M, Montagu D, Incidence of pediatric diarrhea and public-private preferences for treatment in rural Myanmar: a randomized cluster survey Journal of Tropical Pediatrics. Advanced Access Publication, August 8, 2012. 11. Montagu D, Harding A. A zebra or a painted horse? Are hospital PPPs infrastructure partnerships with stripes or a separate species? World Hosp Health Serv. 2012; 48(2):15-9. 12. Yamey G, Schäferhoff M, Montagu D. Piloting the Affordable Medicines Facility-malaria: what will success look like? Bull World Health Organ. 2012 Jun 1; 90(6):452-60. 13. Yamey G, Scaferhoff M, Montagu D, Piloting the Affordable Medicines Facility-malaria (AMFm): what will "success" look like? Bulletin of the World Health Organization. Vol 90,6 2012 PP452-60 14. Aung T, Montagu D, Schlein K, Khine TM, McFarland W. Validation of a new method for testing provider clinical quality in rural settings in low- and middle-income countries: the observed simulated patient. PLoS One. 2012; 7(1):e30196. 15. Sabot O, Schroder K, Yamey G, Montagu D. Scaling up oral rehydration salts and zinc for the

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treatment of diarrhoea. BMJ. 2012; 344:e940. D. Research Support On-going Research Support P0046342 01/01/2012 - 12/31/2012 ExxonMobil Ensuring Proper Malaria Diagnosis and Treatment in Nigeria Role:PI A118380 01/01/2010 - 10/01/2012 Rockefeller Foundation Social Franchising Research Role:PI A115100 05/01/2010 - 06/30/2013 Population Services International PSI/Myanmar Collaborative Impact Studies Role:PI A118573 09/01/2011 - 05/31/2012 Bill and Melinda Gates Foundation Private Sector Analysis Role:PI pending (Foundation Ref: THS 307) 04/01/2013 - 03/31/2015 Rockefeller Foundation Enhancing the Social Franchising Community of Practice: Building a Scientific Foundation for Programs Role:PI P0048793 03/01/2012 - 10/31/2015 Results for Development / Bill and Melinda Gates Foundation Social Franchising Community of Practice Role:PI 07/01/2012 - 05/30/2013 World Health Organization A Systematic Review of Social Franchising Impact on Health Role:PI Completed Research Support HE 007 12/01/2004 - 11/30/2006 Rockefeller Foundation Health Franchising Role:PI A114749 04/15/2010 - 04/14/2012 Results for Development Documenting Informal Providers Role:PI HE 0077; A-2344 10/01/2003 - 12/01/2004 Rockefeller Foundation Health Franchising and Community Insurance Role:PI A21/374/1 07/01/2005 - 12/31/2005 World Health Organization Triangulation of HIV Data in Bostwana

PHS 398/2590 (Rev. 06/09) Page 3 Biographical Sketch Format Page Program Director/Principal Investigator: Dominic Montagu

Role:Co-Researcher H15-370-20 10/01/2005 - 05/31/2006 World Health Organization Private Sector Secretariat Role:PI #1186 11/01/2005 - 10/31/2006 Family Health International Creating a Social Franchising for HIV in Kenya Role:PI 04/01/2007 - 09/30/2007 Abt Associates Evaluating private HIV care in Kenya Role:PI 04/01/2006 - 03/30/2008 Centers for Disease Control / Kenya Triangulation of HIV Data Role:Co-PI A113644 08/01/2009 - 01/31/2011 Rockefeller Foundation Social Franchising Community of Practice Role:PI A113946 11/01/2009 - 10/31/2010 ExxonMobil Private Sector Malaria Treatment Role:PI A11442 04/01/2010 - 12/31/2010 The World Bank Group Private Sector Policy Stewardship Role:PI AA108197 10/01/2007 - 09/30/2011 Bill and Melinda Gates Foundation Analysis to Action Role:Researcher A115457 06/01/2010 - 12/15/2010 UK Department for International Development Systematic Review: under what circumstances do the provision of services by the private and not-for- profit sectors improve the health of the poor? Role:PI A115467 07/01/2010 - 09/30/2011 Rockefeller Foundation Planning for a Pre-Congress Symposium on the Private Sector Role:PI P0039175 01/01/2011 - 12/31/2011 ExxonMobil Malaria Care in Nigeria Role:PI A117063 01/01/2011 - 11/30/2011 World Health Organization

PHS 398/2590 (Rev. 06/09) Page 4 Biographical Sketch Format Page Program Director/Principal Investigator: Dominic Montagu

Social Franchising Conference Role:PI A117309 04/15/2011 - 12/30/2011 Bill and Melinda Gates Foundation First Global Conference on Social Franchising Role:PI

PHS 398/2590 (Rev. 06/09) Page 5 Biographical Sketch Format Page Biographical Sketch – Carmen J. Portillo, Department Chair and Professor eRA Commons User Name: portillo

EDUCATION/TRAINING DEGREE YEAR(s) FIELD OF STUDY University of Arizona, Tucson, AZ BSN 6/1981 Nursing University of Arizona, Tucson, AZ MS 6/1986 Nursing University of Arizona, Tucson, AZ PhD 6/1990 Nursing

A. Personal Statement I am Professor and Chair of the Department of Community Health Systems in the School of Nursing (SON), University of California, San Francisco. I am the Co-Director of the School of Nursing’s HIV/AIDS Nursing Care and Prevention training grant (T32 NR07081). I am currently the Director of a NINR funded T32 in the School of Nursing. My clinical nursing background is in community and mental health nursing. I am PI of three HRSA training grants in the development and training of HIV/AIDS nurse practitioners. My program of research has focused on adherence, stigma, and symptoms in people with HIV/AIDS. Currently, I am Co-PI of a multi-site qualitative research project on understanding health literacy in people with HIV/AIDS and providers in HIV/AIDS. Approximately in 2000, I began collaborating with Dr. William Holzemer on a HIV/AIDS research project that was co-located in 5 African countries. The research focused on stigma among people with HIV/AIDS and for those that cared for people with HIV/AIDS. In 2007, I was funded for four years by the American International Health Alliance for two years to train all the employed nursing faculty in 68 schools of nursing on HIV/AIDS. This project evolved into curricula development and implementing skills labs and other teaching resources supported by CDC. I worked with Dr. Chris Stewart on a R25 NIH Fogarty International grant to provide didactic multidisciplinary learning internationally. As a collaborator on the MUHAS-UCSF Academic Learning Project funded by Bill & Melinda Gates Foundation, I worked on the MUHAS nursing curriculum. I have mentored over 45 doctoral students in my 23 year career and have supported approximately 8 students through the F31 process. I advise five nursing doctoral students; and one entering in September 2014. Over the years since my global involvement, I have informally mentored international nursing students and faculty. I maintain a teaching load in nursing with masters and doctoral students. I am a Fellow of the American Academy of Nursing.

B. Positions and Honors 1985-1989 American Nurses’ Association, Minority Fellow Award 1993-now Member, American Nurses in AIDS Care; Board member Journal of ANAC 1996 Fellow, American Academy of Nursing 1998-2000 President, National Hispanic Nurses’ Association 1999-2003 Member, National Institute of Nursing, NIH, Advisory Council 2002-now Charter Member, National Coalition of Ethnic Minority Nurses Association, Inc. 2003-2005 Specialty Coordinator, Advance Community Health & Intl Nursing, UCSF SON 2009 Sigma Theta Tau, Alpha Eta Chapter, Margretta Madden Styles Award 2009-now Chair, Department of Community Health Systems, School of Nursing, UCSF

C. Selected Peer-reviewed Publications Portillo, C.J., White, M., Baisden, K., & Dawson, C. (1995). Angina, functional impairment and physical inactivity among Mexican American women with depressive symptoms. Progress in Cardiovascular Nursing, 10(3), 18-25. Portillo, C.J., Miramontes, H., & Holzemer, W.L. (1995). Profile: The International Center for HIV/AIDS research and clinical training in nursing. IMPRINT, 42(4), 65-68. Portillo, C. J. & Schumacher, K. L. (1998). A graduate program to prepare nurses for advanced practice in home care. Advanced Practice in Acute and Critical Care, 9(3), 335-361. Portillo, CJ, et al. (2001). Research agenda for Hispanics in the United States: A nursing perspective. Nursing Outlook, 49, 263-269. Baezconde-Garbanati, L., Portillo, C.J., & Garbanati, J.A. (1999). Disparities in health indicators for Latinas in California. Hispanic Journal of Behavioral Sciences, 21(3), August, 302- 329. Villarruel, A.M, Portillo, C.J. & Kane, P. (1999). Communicating with limited English proficiency persons: Implications for nursing practice. Nursing Outlook, 47(6), 262-270. Lee, KA, Portillo, CJ, & Miramontes, H. (2001). The influence of sleep and activity patterns on fatigue in women with HIV/AIDS. JANAC, 12(Supplement), 19-27. Portillo, CJ, Villarruel, A, Siantz de Leon, ML, Peragallo, N, Calvillo, ER, & Eribes, CM. (2001). Research agenda for Hispanics in the United States: A nursing perspective. Nursing Outlook, 49, 263-269. Holzemer, W.L., Rivero Méndez, M., Portillo, C., et al. (2004). The Nursing Research Center on HIV/AIDS Health Disparities. Nursing Outlook, 52, 226-233. Portillo, C.J. et al. (2005). Quality of life of ethnic minority persons living with HIV/AIDS. The Journal of Multicultural Nursing and Health, 11(1), 31-37. Rivero-Mendez, M. Portillo, C., et al. (2008). Symptoms and quality of life for people living with HIV infection in Puerto Rico. PRHSJ, 28(1), 2-7. Rnggli, V., De Ryck, I, Jaco, S., Yenneh, H., Sirgu, S., Sebuyira L.M., l., Pfitzer, A., Downing, J., Portillo, C., et al. (2008). HIV education for health-care professionals in high prevalence countries: time to integrate a pre-service approach into training. Lancet, 372, 341-342. Hudson AL, Portillo CJ, Lee KA. Sleep disturbances in women with HIV or AIDS: efficacy of a tailored sleep promotion intervention. Nurs Res. 2008 Sep-Oct; 57(5):360-6. Makoae, L.M., Portillo, C.J., et al. (2009). A comparison of perceived HIV stigma between persons living with HIV infection who are taking and not taking ARV medications in five African countries. AIDS Care. 21(11):1357-1362. Kohi, T.W., Portillo, C.J., et al. (2010). Does Perceived HIV/AIDS Stigma Contribute to Nurses' Intent to Migrate in Five African Countries. JANAC. 21(2): 134-143. Nicholas, P., Voss, J., Wantland, D., Lindgren, T., Huang, E., Holzemer, W.L., Cuca, Y., Moezzi, S., Portillo, C., et al. (2010). Prevalence, self-care behaviors, and self-care activities for peripheral neuropathy symptoms of HIV/AIDS. Nursing & Health Sci. 12(1):119-126. Gay C, Portillo CJ, Kelly R, Coggins T, Davis H, Aouizerat BE, Pullinger CR, Lee KA. Self- reported medication adherence and symptom experience in adults with HIV. J Assoc Nurses AIDS Care. 2011 Jul-Aug; 22(4):257-68. Nokes, K., Nicholas, P., Rivero, M., Rosa, M., Kirksey, K., Moezzi, S., Corless, I., Maryland, M., Willard, S., Robinson, L., Hamilton, M., Sefcik, E., Wantland, D., Holzemer, W., & Portillo, C. (2011). Sexual function in younger and older HIV+ adults in the United States and Puerto Rica. Aging International. 36:334-345. Hampton MD, Chafetz L, Portillo C. (2012). Differences in substance-related risk behavior between dual and triple diagnosed severely mentally ill adults. Ment Health Subst Use, 5(1):52-63. Rowniak S, Portillo C. Pre-exposure prophylaxis: an ethical discussion. J Assoc Nurses AIDS Care. 2013 Jan; 24(1):6-10. Chen, W.T., Wantland, D., Reid, P., Corless, I.B., Eller, L.S., Iipinge, S., Holzemer, W.L., Nokes, K., Sefcik, E., Rivero-Mendez, M., Voss, J., Nicholas, P.K., Phillips, J.C., Brion, J., Dawson Rose, C., Portillo, C.J., Kirksey, K., Sullivan, K., Johnson, M.O., Tyer-Viola, L., & Webel, A. (2013) Engagement with Health Care Providers Affects Self-Efficacy, Self- Esteems, Medication Adherence and Quality of Life in People Living with HIV. Journal of AIDS and Clinical Research. 4:256. Lee, K.A., Gay, C., Humphreys, J., Portillo, C.J., Pullinger, C.R., Aouizerat, B.E. Telomere length is associated with sleep duration but not sleep quality in adults with Human Immunodeficiency Virus. Sleep. 2014;37(1):157-166. Okonsky, J.O., Webel, A., Dawson Rose, C., Johnson, M., Asher, A., Cuca, Y., Kaihura, A., Hanson, J.E., Portillo, C.J. Appreciating reasons for HIV medication nonadherence in women. Health Care for Women International. In Press.

D. Research and Training Support T32NR07081 Portillo (PD) 1995-2017 NIH/NINR: HIV/AIDS Nursing Care and Prevention This training fellowship support four predoctoral and two postdoctoral trainees each year. The goal is to train nurse researchers to build the knowledge base about HIV/AIDS.

D09HP03285-01-00 Portillo (PI) 2004-2014 DHHS, HRSA, BHP: Positive Health: HIV Advanced Practice Nurse Educ The goal is to prepare advanced practice nurses to provide expert comprehensive services to people living with HIV/AIDS.

D62HP24191 Portillo (PI) 07/01/2012 - 06/30/2015 DHHS, HRSA, CGEP Geriatric and Psychiatric Nurse Training The goal is to prepare nurse practitioners with a concentrated focus in geriatric and psychiatric nursing focus.

H4AHA26223 Portillo (PI) 09/01/2013 - 06/30/2018 DHHS, HRSA, HIV Advanced HIV/AIDS Training for Nurse Practitioners Preparing nurse practitioners to care and treat people with HIV/AIDS. Principal Investigator/Program Director (Last, First, Middle):

NAME POSITION TITLE Rankin, Sally H. eRA COMMONS USER NAME Professor Rankins EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Duke University, Durham, NC -- 1962-64 Sociology Boston University, Boston, MA BA(cum laude) 1966 Sociology California State Univ., Los Angeles BSN (magna) 1974 Nursing Duke University, Durham, NC MSN 1978 Nursing Univ. of California, San Francisco PhD 1988 Nursing

A. Personal Statement My teaching and research since 1988 has focused on chronic diseases, primarily cardiovascular, diabetes mellitus, and HIV. My teaching at UCSF has been primarily in the doctoral program in the School of Nursing. I have either chaired or been on the dissertation committees of 81 doctoral students at Boston College and UCSF am well prepared to work with students enrolled in the proposed PhD program in Global Health Sciences. I have been a faculty member on the UCSF School of Nursing’s T32 on HIV/AIDS Nursing Care and Prevention and have mentored numerous international students at UCSF and Boston College. I currently advise students in the GHS masters program and have mentored students’ capstone projects in Malawi yearly since 2011. I serve on the University of California Global Health Institute (UCGHI) Fogarty funded pre- and post-doctoral GloCal Steering Committee and have been a member of the admissions screening committee for the last 3 years.

My sixth NIH funded project, Malawi Christians and Muslims: HIV prevention and care (R01 HD 050147) was a mixed methods study of 750 participants who were members of 5 different Malawi religious groups. The primary study aim was to: 1) describe the strategies used by 5 Christian and Muslim religious groups to prevent HIV infection and to care for people living with HIV/AIDS (PLWHA). Concurrent with this study I was co-investigator on a planning grant that was funded by the Doris Duke Charitable Trust African Health Initiative. Following this work I collaborated with Dr. Lynda Wilson from the University of Alabama-Birmingham on a proposal in response to a RFA from the Bureau of Educational and Cultural Affairs (ECA), United States Department of State. The purpose of this project focused on Malawi and Zambia was to train public health and other health care professionals in their work with marginalized groups. Currently I am part of the faculty group in the School of Nursing working on the Preterm Birth (PTB) Initiative. If funded, my group of 4 projects would work in Malawi.

Other global health experience includes my work with a large USAID project funded through the Global Health Initiative, Building the Nursing Workforce & Nurse Training Capacity in Malawi on which I am the sub-contract PI. The purpose of this project is build pre-service and in-service nursing capacity in Malawi in the areas of HIV, ART, Basic Emergency Obstetric and Newborn Care, and triage. This project has required interface with the Ministry of Health and other Malawi governmental agencies.

B. Positions and Honors. Positions and Employment 1974-75 Duke University Medical Center, Durham, NC, Staff Nurse 1975-77 Durham County General Hospital, Durham, NC, Inservice Education Instructor 1978-80 Duke University School of Nursing, Durham, NC, Instructor 1980-82 Mt. St. Mary's College, Los Angeles, Chalon Campus, Assistant Professor 1982-83 University of Southern California, Los Angeles, Assistant Professor PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): 1988-90 University of California, San Francisco, Assistant Clinical Professor 1990-93 University of California, San Francisco, Assistant Professor 1993-98 Boston College School of Nursing, Chestnut Hill, MA, Associate Professor and Director, Family Nurse Practitioner Program 1998-2004 University of California, San Francisco, Associate Professor & Director, FNP Program University of California, San Francisco, Professor & Director, FNP Program 2004-2010 Chair, Department of Family Health Care Nursing, University of California, San Francisco 2010-now Associate Dean, UCSF School of Nursing International Programs and Global Health 2010-2011 Interim Dean, UCSF School of Nursing

Honors 1984-85 University of California Regents Fellowship 1985-88 National Research Service Award (F31NR05787) 1987-88 USCSF Chancellor's Graduate Research Fellowship 1987 Outstanding Student Award, National Council on Family Relations, Runner-up 1987-88 American Heart Association, SF Chapter, Clinical Nursing Research Fellowship 1989 Carol A. Lindeman Award for a New Researcher, Western Society for Research in Nursing, Western Institute of Nursing 1994 Distinguished Alumna Award, Duke University School of Nursing 1995 Fellow of the American Academy of Nursing (FAAN) 2001 Harriet Cook Carter Lecturer, Duke University School of Nursing Alumnae Day 2002 UCSF Graduate Student Association Faculty Mentorship Award (Nominee) 2004 Doctoral Mentor of the Year Award, UCSF Doctoral Students 2005 Best Abstract Award, American Heart Association 2007 Achievement in Research Award, National Organization of Nurse Practitioner Faculties 2011 Margretta Styles Award for Excellence in Nursing, Alpha Beta Chapter of Sigma Theta Tau 2012 Duke University School of Nursing, Distinguished Nurse Researcher Award

B. Selected Peer-Reviewed Publications (In chronological order; 17 out of 65 peer-reviewed). 1. Rankin, S.H. (1990). Differences in recovery from cardiac surgery: A profile of male and female patients. Heart and Lung, 19, 481-486. 2. Rankin, S.H., & Monahan, P. (1991). Great expectations: Perceived social support in couples experiencing cardiac surgery. Family Relations, 40, 297-302. 3. Rankin, S.H., Galbraith, M.E., & Johnson, S. (1993). Reliability and validity data for a Chinese translation of the Center for Epidemiologic Studies - Depression (CES-D). Psychological Reports, 73, 1291-1298. 4. Rankin, S.H., Galbraith, M.E., & Huang, P. (1997). Quality of life and social environment as reported by Chinese immigrants. The Diabetes Educator, 23, 171-177. 5. Jayne, R. L. & Rankin, S. H. (2001). Application of Leventhal’s self-regulation model to Chinese immigrants with type 2 diabetes. Journal of Nursing Scholarship, 33, 53-59. 6. Rankin, S. H. (2002). Women recovering from acute myocardial infarction: Psychosocial and physical functioning outcomes for twelve months post-AMI. Heart and Lung: The International Journal of Critical Care, 31, 399-410. 7. Rankin, S.H., Lindgren, T., Rankin, W.W., & Ng’oma, Joyce (2005). Donkey work: Women, religion, and HIV/AIDS in Malawi Health Care for Women International, 26, 4-16. 8. Lindgren, T. Rankin, S.H, & Rankin, W.W. (2005). Malawi Women and HIV Socio-Cultural Factors and Barriers to Prevention. Women and Health, 41, 69-86. 9. Rankin, W.W., Brennan, S., Schell, E., Laviwa, J., & Rankin, S.H. (2005). The stigma of being HIV-positive in Africa. Public Library of Science-Medicine, 2(8), 1-3. 10. Joronen K, Rankin SH, Astedt-Kurki P. School-based drama interventions in health promotion for children and adolescents: Systematic review, J Adv Nurs, 63(2), 116-131, 2008. 11. Rankin, SH, Lindgren, T, Kools, S, Schell, E. The Condom Divide: Disenfranchisement of Malawi women by church and state, JOGNN, 37(5), 596-604, 2008. 12. Morris, LM, Schell, E, Schell, D, Rankin, SH. (2008). Theologies of blame and compassion in the response of religious organizations to the AIDS crisis in Malawi, Central Africa. Jnl of Rel in Malawi. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): 13. Schell E S, Rankin W, Chipungu G, Rankin S, & Weiller R. Building the nursing workforce in Malawi. American Journal of Nursing. 2011;111(6):65-7. 14. Lindgren T G, Deutsch K, Schell E, Bvumbwe A, Hart K B, Laviwa J & Rankin SH. Using mobile clinics to deliver HIV testing and other basic health services in rural Malawi. Rural and remote health. 2011;11(2):1682-. 15. Rankin SH, Rankin SH, Kools S, Nyagondwe Fiedler R, Schell E, Phiri J, & Mguntha A.“The wind of openness”: Religious organizations, Malawi youth and HIV. Int Jnl of Adolesc Health. 2011; 4(2): 141-153. 16. Macintyre, L M, Rankin, S, Pinderhughes, H, et al. (2013). Socially disempowered women as the key to addressing change in Malawi: how do they do it?. Health Care For Women International, 34(2), 103-121. 17. Lindgren, T, Schell, E, Rankin, S, et al. (2013). A Response to Edzi (AIDS): Malawi Faith-Based Organizations' Impact on HIV Prevention and Care. Journal of the Association of Nurses in AIDS Care, 24(3), 227-241.

Books and Book Chapters 1. Rankin, S.H., & Duffy, K.L. (1983, 1990, 1996, 2001, 2005). Patient Education in Health and Illness. Philadelphia: Lippincott (textbook). 2. Rankin, S.H. (1989). Family transitions: Expected and unexpected. In C.L. Gilliss, B. Highley, B. Roberts, & I. Martinson (eds.). Towards a science of family nursing. Menlo Park: Addison-Wesley. 3. Rankin, S.H. (1989). The emergence of creativity in later life. In R.T. Mercer, E.G. Nichols, & G.C. Doyle (eds.). Transitions in a woman's life: Major life events in developmental context. New York: Springer. 4. Rankin, S.H. Rankin, SH. (2008) The impact of cardiac disease on the family (217-227). In: Riegel, B and Moser, D, eds. Cardiac nursing: A companion to Braun. New York: Elsevier. 5. Rankin, S. H. & Rankin, W.W. (2009) Building knowledge. In W.L. Holzemer (ed.), Improving health through nursing research. (pp. 16-25).

C. Research Support. Ongoing Research Support

1. U.S. Agency for International Development, Malawi Mission (PI on subcontract) Global Development Alliance & Global Health Initiative 2010-2015 Building the Nursing Workforce & Nurse Training Capacity in Malawi $1,750,762

Past Research Support 1. U.S. Department of State, Bureau of Educational and Cultural Affairs (Rankin, PI on subcontract) Promoting Global Health by Strengthening Capacity for Education of Health Professionals through a Professional Fellows Program Involving Faculty from Zambia, Malawi, Alabama, and California. ECA/PE/C-10- 01; Federal Domestic Assistance Number: 19.415. 10/1/10-9/30/12; $222,047. 2. 1 RO1 HD050147-01 (Rankin, PI) Malawi Christians and Muslims: HIV Prevention and Care; 8/10/06 – 7/31/11; NIH / NICHD; $881,239 3. Integrated Primary Health Care and Workforce Training in Zomba District Malawi (Rankin Co-I) 10/1/08- 3/31/09; Doris Duke Charitable Foundation, African Health Initiative; $150,000. 4. 2 D09HP00570-04 00 (Rankin Co-PI) Primary Care of High-Risk Populations: The PrimeRISK II Program; 7/1/03 - 6/30/09; HRSA, Department of Health and Human Services. 5. R01 NR05205 (Rankin PI) Improving Health Outcomes for Elderly Unpartnered Cardiac Patients; 2000- 2004; National Institute of Nursing Research/NIH; $1,116,545. 6. R15 NR04255 Rankin (PI); Improving health outcomes for elderly unpartnered MI patients; 1996-99; National Institute of Nursing Research/NIH; $117,000. 7. R55 NR 021617 (Shannon Award) Rankin (PI); African- and Anglo-American women adapting to MI; 1992- 95; National Institute of Nursing Research/NIH; $100,000. 8. R21 DK45184 Rankin (PI); Managing diabetes mellitus in a U.S. Chinese population; 1992-94; National Institute of Diabetes, Digestive, and Kidney Diseases; $25,000.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Arthur L. Reingold, MD Professor, Division of Epidemiology eRA COMMONS USER NAME (credential, e.g., agency login) Associate Dean for Research, Reingold School of Public Health EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Chicago, Chicago, Illinois AB 1970 Biology University of Chicago, Chicago, Illinois MD 1976 Medicine

A. Personal Statement Dr. Reingold has been conducting field studies of various infectious diseases in the U.S. and in multiple developing countries for 30+ years, including studies of healthcare associated infections; bacterial meningitis and pneumonia; tuberculosis, malaria, and HIV/AIDS; influenza; and various vaccine preventable diseases in children and adults. As the director of the NIH-funded UCB/UCSF AIDS International Training and Research Program (AITRP) since 1988, Dr. Reingold has provided degree (masters and doctoral) and non-degree training to numerous young investigators from multiple developing countries, including Brazil, Peru, India, Vietnam, Uganda, Zimbabwe, Ivory Coast, and Kenya. In his role as co-director of the NIH-funded Infectious Diseases Training Program at UCSF and through his work with pre- and post-doctoral trainees at UC Berkeley, Dr. Reingold has also mentored numerous U.S. physicians, veterinarians, dentists, and PhD researchers conducting infectious disease research in the U.S. and internationally. He currently serves on the Training Advisory Committee of the NIH-funded Medical Education Partnership Institute (MEPI) of the University of Zimbabwe. Based on my experience in clinical research training programs and global health and research capacity development, I am qualified to be a member of the the UCB-UZ HIV Research Training Program’s Training Advisory Committee.

B. Positions and Honors:

• Professor and Head, Division of Epidemiology, School of Public Health, University of California, Berkeley.

• Professor of Epidemiology & Biostatistics/Clinical Professor of Medicine, University of California, San Francisco

• Associate Dean for Research, School of Public Health, University of California, Berkeley

• Edward Penhoet Distinguished Chair of Global Health and Infectious Diseases

• Member, Institute of Medicine

1979-1980 Epidemic Intelligence Service Officer - Connecticut State Department of Health Services, Hartford, Connecticut

1980-1981 Epidemic Intelligence Service Officer - Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia

1981-1985 Assistant Chief, Respiratory and Special Pathogens Epidemiology Branch, Division of Bacterial Diseases, Center for Infectious Diseases, Centers for Disease Control - Atlanta, Georgia

1985-1987 Centers for Disease Control (CDC) Liaison Officer, Office of the Director, CDC - Atlanta, Georgia PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): C. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in preparation. 1. Muhammad RD, Oza-Frank R, Zell E, Link-Gelles R, Venkat Narayan KM, Schaffner W, Thomas A, Lexau C, Bennett NM, Farley MM, Harrison LH, Reingold A, et al. Epidemiologoy of invasive pneumococcal disease among high-risk adults since the introduction of pneumococcal conjugate vaccine for children. Clin Inf Dis 2013;56:e59-67.

2. Cox CM, D’Melio T, Perez A, Reingold A, Gershman K, et al. Increase in rates of hospitalization due to laboratory-confirmed influenza among children and adults during the 2009-2010 influenza pandemic. J Inf Dis 2012; 206:1350-1358.

3. Livorsi DJ, MacNeil JR, Cohn AC, Bareta J, Zansky S, Petit S, Gershman K, Harrison LH, Lynfield R, Reingold A, et al. Invasive Haemophilus influenza in the United States, 1999-2008: Epidemiology and Outcomes. J Inf Dis 2012; 65:496-504.

4. Terrault NA, Dodge JL, Murphy EL, Tavis JE, Kiss A, Levin TR, Gish RG, Busch MP, Reingold AL, Alter MJ. Sexual transmission of hepatitis C virus among monogamous heterosexual couples: The HCV partners study. Hepatology; 2013;53:881-889.

5. Muhammed RD, Oza-Frank R, Zell E, Link-Gelles R, Venkat Narayan KM, Schaffner W, Thomas A, Lexau C, Bennett NM, Farley MM, Harrison LH, Reingold A, et al. Epidemiology of invasive pneumococcal disease among high-risk adults since the introduction of pneumococcal conjugate vaccine for children. Clin Inf Dis 2013;56:e59-e67.

6. Fleming-Dutra KE, Taylor T, Link-Gelles R, Garg S, Jhung MA, Finelli L, Jain S, Shay D, Chaves SS, Baumbach J, Hancock EB, Beall B, Bennett N, Zansky S, Petit S, Yousey-Hindes K, Farley MM, Gershman K, Harrison LH, Ryan P, Lexau C, Lynfield R, Reingold A, et al. Effect of the 2009 influenza A(H1N1) pandemic on invasive pneumococcal pneumonia. J Inf Dis 2013;207:1135-1143.

7. Kamimoto L, Euler GL, Lu P-J, Reingold A, Hadler J, Gershman K, et al. Seasonal influenza morbidity estimates obtained from telephone surveys, 2007. Am J Pub Hlth 2013;103:755-763.

8. Salmon DA, Proschan M, Forshee R, Gargiullo P, Bleser W, Burwen DR. . .H1N1 GBS Meta-Analysis Working Group (Reingold AL-member). Association between Guillain Barré syndrome and influenza A (H1N1) 2009 monovalent inactivated vaccines in the USA: A meta-analysis. Lancet 2013;381:1461-1468.

9. Dawood FS, Chaves SS, Perez A, Reingold A, Meek J, Farley MM, et al. Complications and associated bacterial coinfections among children hospitalized with seasonal or pandemic influenza, United States, 2003-2010. J Inf Dis 2013; Epub DOI: 10.1093/infdis/jit473.

10. Thompson MG, Sokolow LZ, Almendares O, Openo K, Farley MM, Meek J, Ray J, Daily Kirley P, Reingold A, et al. Effectiveness of nonadjuvanted monovalent influenza A (H1N1) pdm09 vaccines for preventing reverse transcription polymerase chain reaction-confirmed pandemic influenza hospitalizations: Case- control study of children and adults at 10 U.S. influenza surveillance network sites. Clin Inf Dis 2013;11:1587-1592.

11. Wiringa AE, Shutt KA, Marsh JW, Cohn AC, Messonnier NE, Zansky SM, Petit S, Farley MM, Gershman K, Lynfield R, Reingold A, et al. Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. PLoS One 2013;8:e82048l doi:10.1371/journal.pone.0082048.

12. Jhung MA, D’Mello T, Perez A, Aragon D, Bennett NM, Cooper T, Farley MM, Fowler B, Grube SM, Hancock EB, Lynfield R, Morin C, Reingold A, et al. Hospital-onset influenza hospitalizations – United States, 2010-2011. Am J Inf Control 2014; 42:7-11. D. Research Support. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Ongoing

California Emerging Infections Program (A. Reingold, P.I.) 01/01/12 - 12/31/17 Centers for Disease Control and Prevention (CDC) 235.006.901 California Emerging Infections Program This CDC-funded research program, which has been in place since 1994, is a collaborative effort of the School of Public Health, the University of California, Berkeley, the California Department of Public Health Services, and selected county health departments. The program is funded to study a wide range of infectious diseases, including viral hepatitis; viral encephalitis; foodborne enteric infections (bacterial and viral); bacterial meningitis and pneumonia; influenza; waterborne infections, and unexplained illnesses and deaths, among others. The goal of this cooperative agreement is to study a variety of emerging/re- emerging infectious diseases in California.

Fogarty International AIDS Research Training Program (A. Reingold, P.I.) 06/01/08 – 05/31/14 National Institutes of Health/Fogarty Center D43-TW00003 Fogarty International AIDS Training grant This NIH-funded training program in place since 1988, is designed to train physicians, laboratory scientists, and others from selected developing countries in how to conduct high quality, epidemiologic, virologic, immunologic, behavioral, and health policy-related AIDS research. Dr. Reingold has been the principal investigator since the program’s inception in 1988. The goal of this grant is to train medical personnel from third-world focus countries in AIDS-related research/training techniques.

Berkeley Minority Health/Global Health (MH/GH) Training Program (A. Reingold, P.I.) 06/01/09 – 11/30/14 NCMHD Minority Health and Health Disparities International Research Training The Berkeley Minority Health/Global Health Training Program provides training of junior investigators in health disparities research, including provision of research experiences in low-resource settings in the developing world and will replenish the pipeline of health professionals and health scientists to be able to effectively address public health disparities in the United States.

UCB-UCSF-MU Research Training on TB and Other Pulmonary Complications of HIV (A. Reingold, P.I.) 08/01/13 – 01/31/18 NIH Fogarty International Center This program will train medical doctors, scientists, laboratory technicians, and other research support personnel at Makerere University College of Health Sciences and Mulago National Referral Hospital in translational research methods for the study of pulmonary complications of HIV. This will strengthen the capacity of these institutions to conduct high quality, innovative, and locally relevant HIV/AIDS research.

HIV Implementation Science and Research Training Program (FHISTRP) (A. Reingold, P.I.) 08/01/13 – 01/31/18 NIH Fogarty International Center This training program provides HIV/AIDS-related research training in conjunction with and support of the University of Zimbabwe’s College of Health Sciences, in Harare, Zimbabwe. The training program is intended to strengthen the faculty of the College of Health Sciences, which has been severely diminished over the past decade by economic and social problems in Zimbabwe.

Completed N/A

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Reynolds, Teri A BIOGRAPHICAL SKETCH

NAME POSITION TITLE Teri A. Reynolds Assistant Professor and Director of Global Health, eRA COMMONS USER NAME: TERIR1 Department of Emergency Medicine, UCSF Emergency Medicine Residency Program Director, Muhimbili National Hospital, Dar es Salaam, Tanzania EDUCATION/TRAINING DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Columbia University, New York, NY BA 1992 Literature Columbia University PhD 2001 Literature UCSF School of Medicine, San Francisco, CA MD 2004 Medicine Highland General Hospital, Oakland, CA Residency 2005-09 Emergency Medicine UCSF Global Health Sciences MS 2009-10 Global Health UCSF Department of Emergency Medicine Fellowship 2009-10 Emergency Ultrasound Reynolds, Teri A

A. Positions and Honors

Positions and Employment 1998-99 Instructor, Literature and Medicine, The New York Academy of Medicine, New York 2000 Instructor, Theory and Practice of Science, Dept. of Biology, Columbia University, New York 2001-02 Instructor, Literature and Medicine, UCSF School of Medicine 2005-2009 Emergency Medicine Residency, Alameda County Medical Center (Highland Hospital) 2008-2009 Chief Resident, Emergency Medicine, Alameda County Medical Center (Highland Hospital) 2009-10 Emergency Ultrasound Clinical Fellow, Department of Emergency Medicine, UCSF 2010 World Health Organization, Geneva. Technical Officer, Human Resources for Health 2011-pres Assistant Professor of Emergency Medicine, UCSF 2011-pres Emergency Medicine Residency Program Director, Muhimbili National Hospital, Dar es Salaam,Tanzania. 2013 World Health Organization Global Alliance for the Care of the Injured, Secretariat

Other Experience 2013-present Emergency Medicine Journal (BMJ). Associate Editor 2008-2011 Annals of Emergency Medicine. Editorial Board member. Podcast Editor. 2008 Associate Editor, Emergency Management of Infectious Diseases, Cambridge University Press, 2008. 2004-2005 Founder and Editor, The Learning Curve section, Medscape General Medicine/ WebMD 2003-2007 Journal of the American Medical Association, Student JAMA. Assoc. Editor, Deputy Editor, Editor-in-Chief 2004-05 World Health Organization, Geneva. Consultant, Integrated Management of Adult Illness (IMAI) 2003 World Health Organization, Intern, IMAI Working Group.

Honors 2013 Society for Academic Emergency Medicine EM Globalization and Advancement Award 2010-2013 UCSF Burke Family Global Health Faculty Award 2009 USCF Department of Emergency Medicine “Backbone” Resident Award 2007-08 Annals of Emergency Medicine Resident Editorial Fellowship 2004 Alpha Omega Alpha – UCSF Medical School 2003, 2004 UCSF Dean's Quarterly Research Fellowship 1999 Endocrine Society Research Fellowship 1992-98 Columbia University President's Fellowship 1991-92 Marjorie Hope Nicolson Fellowship 1987 Experiment in International Living Fellowship to Kenya

B. Publications

1. Issue Editor, MSJAMA: Gross Anatomy. Author: Dissecting Gross Anatomy. JAMA. 2002; 287:1178-1185.

2. Issue Editor, MSJAMA: Creative Writing. Author: Once Upon a Time... JAMA. 2003; 289:612-617.

3. Issue Editor, MSJAMA: Covering the Uninsured. Author: Do the Math. JAMA. 2003; 289:1161-1168.

4. Reynolds TA, Tierney LM Jr. Student JAMA. Medical education in modern China. JAMA. 2004; 291:2141.

5. Reynolds TA, Commentary on “Emergence of Antimicrobial-Resistant Serotype 19A Streptococcus pneumoniae— Massachusetts, 2001-2006.” Annals of Emergency Medicine. 2008; 51: 314-315.

6. Reynolds TA, Frazee BW. Bacterial Skin and Soft Tissue Infections. Emergency Management of Infectious Diseases, Cambridge University Press, 2008.

7. Associate Editor, Emergency Management of Infectious Diseases, Cambridge University Press, 2008.

8. Reynolds, TA, D. L. Schriger, et al. (2008). Annals of emergency medicine journal club. Annals of Emergency Medicine 2008;52:557-560, 2008.

Reynolds, Teri A

9. Reynolds TA, Schriger DL. Conduct and Reporting of Meta-analyses of Studies of Diagnostic tests, and a Consideration of ROC curves. Annals of Emergency Medicine. 2010; 55:60-61.

10. Tabas JA, Reynolds TA. Issue Co-Editors. High-Risk Presentations in Emergency Medicine. Emergency Medicine Clinics of North America. 2010; 28.

11. The Family Room, in Becoming A Doctor, W. W. Norton, 2010.

12. Reynolds TA. Ultrasound of the Spleen. Partners in Health Manual of Ultrasound. 2010.

13. Reynolds TA. How the Other Half Heals. Harpers. July 2010.

14. Reynolds TA, Callaham ML. A survey of past participants in the Annals of Emergency Medicine editorial board fellowship program. Annals of Emergency Medicine. 2011 Feb; 57(2):161-4.

16. Wang R, Reynolds TA, West HH, Ravikumar D, Martinez C, McAlpine I, Jacoby VL, Stein JC. Use of a β-hCG Discriminatory Zone With Bedside Pelvic Ultrasonography. Annals of Emergency Medicine. Feb 2011.

17. Stein JC, Jacoby VL, Vittinghoff E, Wang RC, Kwan E, Reynolds TA, McAlpine I, and Gonzales R. Differential Utilization Rates of Diagnostic Ultrasound in United States Emergency Departments by Time of Presentation. Western Journal of Emergency Medicine. 2011 Feb;12(1):90-5.

18. Celletti F, Reynolds TA, Wright A, Stoertz A, Dayrit M, 2011 Educating a New Generation of Doctors to Improve the Health of Populations in Low- and Middle-Income Countries. PLoS Med 8(10): 2011. e1001108. doi:10.1371/journal.pmed.1001108.

19. Nicks BA; Sawe HR. Mfinanga JA; Reynolds TA. The State of Emergency Medicine in the United Republic of Tanzania. African Journal of Emergency Medicine 2(3):97.

20. Reynolds TA, Mfinanga JA, Sawe HR, Runyon MS and Mwafongo V. Emergency care capacity in Africa: A clinical and educational initiative in Tanzania. Journal of Public Health Policy. 2012 Dec; 33(S1):S126.

21. Reynolds TA. A Tunisian, a Canadian, and an American walk into a bar (sustaining mild head injury). Annals of Emergency Medicine. 2013 May; 61(5):528-9. doi:10.1016/j.annemergmed.2012.12.006. Epub 2013 Jan 30.

22. Calvello E, Reynolds TA, Hirshon JM, Buckle C, Moresky R, O’Neill J, et al. Emergency care in sub-Saharan Africa: Results of a consensus conference. African Journal of Emergency Medicine. 2013 Mar;3(1):42–8.

23. Reynolds TA, Wallis LA. Addressing African acute care needs through consensus-building. African Journal of Emergency Medicine. 2013 Mar;3(1):1–2.

24. Mowafi H, Dworkis D, Bisanzo M, Hansoti B, Seidenberg P, Obermeyer Z, Hauswald M, Reynolds TA. Making the Recording and Analysis of Chief Complaint a Priority for Global Emergency Care Research in Low-Income Countries. Academic Emergency Medicine, 2013 Dec; 20(12):1241-45.

25. Reynolds TA, Bisanzo M, Dworkis D, Hansoti B, Obermeyer Z, Seidenberg P, Hauswald M, Mowafi H. Research Priorities for Data Collection and Management Within Global Acute and Emergency Care Systems. Academic Emergency Medicine, 2013 Dec; 20(12):1246-50

26. Wallis LA, Reynolds TA. AFEM Handbook of Acute and Emergency Care. Oxford University Press,

27. Reynolds TA. A Tunisian, a Canadian, and an American walk into a bar (sustaining mild head injury). Annals of Emergency Medicine. 2013 May; 61(5):528-9.

28. Sawe HR, Murray BL, Reynolds TA. Letter to the Editor: Causes of Fever in Outpatient Tanzanian Children. New England Journal of Medicine. 2014 June; 370(23).

Reynolds, Teri A

C. Current Funding:

Reynolds (PI): UCSF Global Health Sciences Burke Family Foundation award ($166,500, 2011-14)

Reynolds (PI): Abbott Fund Foundation award (to date $2,182,000, 2011- 2014) for Tanzania Emergency Medicine Initiative, funding to direct Emergency Medicine Residency Program at Muhimbili Hospital and coordinate 5 university consortium to provide faculty to Muhimbili National Hospital).

Reynolds (Co-PI): UCSF Resource Allocation Program ($29,700, 2013-14) “Assessment of burns in resource limited settings via teleconsultation”.

Principal Investigator/Program Director (Last, First, Middle): Rosenthal, Philip J. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES NAME POSITION TITLE Philip J. Rosenthal Professor

eRA COMMONS USER NAME rosnthl EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) SUNY at Stony Brook B.S. 1974-78 Biochemistry New York University M.D. 1978-82 Medicine University of Michigan Hospitals Residency 1982-85 Medicine University of California, San Francisco Fellowship 1985-88 Infectious Diseases A. Personal statement. I have studied molecular, clinical, and epidemiological aspects of malaria for over 25 years, including basic and drug discovery studies at UCSF and clinical and epidemiology studies in Uganda and Burkina Faso. I have trained about two dozen postdoctoral fellows and about four dozen predoctoral students in various aspects of malaria research. I have overseen a training grant from the Fogarty International Center, entitled “Training in Malaria Research in Uganda” since 2000, with about 50 Ugandan trainees to date. I have served as faculty on other training grants and participated in many didactic training activities. Thus, I believe that I am well qualified to continue to lead our training program in Uganda. B. Positions and Honors Positions: 1987-1988: Consultant, World Health Organization; 1988-1995: Assistant Professor; 1995-2002: Associate Professor; 2002-: Professor Dept. of Medicine, University of California, San Francisco; 2014-: Editor-in-Chief, American Journal of Tropical Medicine and Hygiene Selected Honors & Service (since 2000): Ed. Board, Antimicrob Agents Chemother, 2000-; Review U.S. Military Inf. Dis. Res. Prog., 2000; Review NIH/NIAID Challenge grants: Medicines for Malaria, 2000; Review NIH/NIAID Malaria vaccine development: anemia (chair), 2001; UCSF Sandler Center for Basic Res. in Parasitic Dis. Advisory Board, 2002-12 ,Co-director 2006-12; Ed. Board, Am J Trop Med Hyg, 2002-; Review NIH/NIAID: Parasitology, 2002; Review NIH/NIAID ICER Clinical research and management training, 2002; Review NIH/NIAID Innovative Approaches for Combating antimicrobial resistance, 2002; Review NIH/NIAID: Parasitology (chair), 2003; Plenary Speaker, 4th Conf. on Proteases, Portoroz, Slovenia, 2004; Doris Duke Distinguished Clinical Scientist Award, 2004-12; Medicines for Malaria Venture Project of the Year, 2005; Review NIH/NIAID: Int. Collab. Inf. Dis. Res. (ICIDR), 2005; Scientific Advisory Committee, MR4, 2005-9; Ed. Board, J Inf Dis, 2006-; Plenary Speaker, Seattle Parasitology Conf., 2006; Review NIH/NIAID: Parasitology, 2006; WHO Tropical Disease Research Expert Drug Discovery Advisory Committee, 2008-11; MIM/TDR Task Force on Research Capability Strengthening in Africa, 2009-11; Review NIH/NIAID Challenge Grants, 2009- 10; Review NIH/NIAID Drug Discovery Study Section, 2010, 2013; Plenary Speaker, H3-D Drug Discovery Symposium, Cape Town, 2012; NIH Special Emphasis Panels, 2011-14; NIH/NIAID Board of Scientific Counselors Review, 2013; Chair, Data Safety Monitoring Board, Primaquine Dosing Study, 2013-; Editor-in- Chief, Am J Trop Med Hyg, 2014- C. Selected Relevant Publications (from >300) Dorsey G, Kamya MR, Singh A, Rosenthal PJ: Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis, 183:1417-1420, 2001. Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ: A randomized trial of amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Lancet, 358:368-374, 2001. Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ: Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet 360:2031-2038, 2002. Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ: Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the treatment of uncomplicated malaria in Ugandan children. J Infect Dis, 188: 1231-1238, 2003.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, first, middle): Rosenthal, Philip J. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G: Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis, 189:2220-2226, 2004. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ: Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet, 364:1950-57, 2004. Dorsey, G., Dokomajilar, C., Kiggundu, M., Staedke, S. G., Kamya, M. R., Rosenthal, P. J.: Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg, 71: 758-763, 2004. Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother, 49:2983-2985, 2005. Yeka A Banek K Bakyaita N Staedke SG Kamya MR Talisuna A Kironde F Nsobya SL Kilian A Slater M Rein- gold A Rosenthal PJ Wabwire-Mangen F Dorsey G. Artemisinin versus non-artemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Medicine,2:e190,2005. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Am J Trop Med Hyg, 73:826-32, 2005. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis, 193:978-86, 2006. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 50:1893-5, 2006. Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. Short report: Dynamics of P. falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg. 74:758-61, 2006. Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg. 75:162-5, 2006. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB: Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparummalaria in Burkina Faso: a randomized controlled trial. Lancet, 369:491-8, 2007. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA. 297:2210-9, 2007. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 51:3023-5, 2007. Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. Impact of Transmission Intensity on the Accuracy of Genotyping to Distinguish Recrudescence from New Infection in Antimalarial Clinical Trials. Antimicrob Agents Chemother. 51:3096-3103, 2007. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis. 45:1453-61, 2007. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. Rapid Diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis, 197:510-8, 2008. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis, 198:393-400, 2008. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ: Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis., 198:1554-7, 2008. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya M, Hubbard A, Rosenthal PJ, Dorsey G. Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis 199:758-65, 2009. PMC2733854

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, first, middle): Rosenthal, Philip J. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ. Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet, 373:1623-31, 2009. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosen- thal PJ, Talisuna AO. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial BMJ. 339:b2763, 2009. PMC2714631 Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis. 49:1629-37, 2009. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 200:1650-7, 2009. PMC2782860 Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 54:1200- 6, 2010. PMC2825959 Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether- lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. Antimicrob Agents Chemother. 54:1949-54, 2010. PMC2863637 Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children PLoS One. 5: e11759, 2010. PMC2912768 Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011;55:615-22PMC3028814 Nsanzabana C, Rosenthal PJ. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011;55:5073-7, 2011. PMC3194998 Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis. 2011;204:19-26. PMC3105040 Rosenthal PJ. Lessons from sickle cell disease in the treatment and control of malaria. N Engl J Med. 364:2549-51, 2011. Baliraine FN, Rosenthal PJ. Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 204:1120-4, 2011. PMC3164433. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.N Engl J Med. 367:2110-8, 2012. PMC3664297. Leclair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ. Optimization of a ligase detection reaction fluorescent microsphere assay for the characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. J Clin Microbiol, 51:2564-70, 2013. PMC3719660. Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ. Fitness consequences of Plasmodium falciparum pfmdr1 polymorphisms inferred from ex vivo culture of Ugandan parasites. Antimicrob Agents Chemother, 57:4245-51, 2013. PMC3754360. Rosenthal, PJ: The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol. 89:1025- 38, 2013. PMC3792794 Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis., 2014 210:154-7. Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR: Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized placebo-controlled trial. Clin Inf Dis, 58:1404-12, 2014. PMC4001293 Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ: Comparative impacts over 5 years of artemisinin-based combination PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, first, middle): Rosenthal, Philip J. therapies on P. falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis, 210:344-53, 2014. Mbogo GW, Nanokoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ: Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg, 91:54-61, 2014. PMC4080569 Nanokoberanyi S, Mbogo GW, LeClair N, Conrad MD , Tumwebaze P, Tukwasibwe S, Kamya M, Tappero J, Nsobya S, Rosenthal PJ: Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Mal J, 13:95, 2014. PMC4004386 Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med, in press. Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ. Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. Antimicrob Agents Chemother, 58:3660-65, 2014. PMC4068591. Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G. Longitudinal Outcomes in a Cohort of Ugandan Children Randomized to Artemether-Lumefantrine Versus Dihydroartemisinin-Piperaquine for the Treatment of Malaria. Clin Infect Dis, in press. D. Research support. ONGOING: Project Number: 1RO1AI075045 (PI: Rosenthal) Dates: 7/09-6/14 (renewal anticipated; priority score=10; percentile=1.0) Source: NIH/NIAID Title: Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Aims: (1) To identify genotypes associated with decreased responses to ACTs in Africa. (2) To assess molecular mechanisms and parasitological consequences of increasing resistance to ACTs. (3) To characterize the specific impacts of parasite polymorphisms on drug sensitivity and fitness. Project Number: 5D43TW007375-07 (PI: Rosenthal) Dates: 7/05-6/15 (renewal pending) Source: NIH (Fogarty International Center) Title: Training in Malaria Research in Uganda Major goals: Training Ugandan investigators in clinical, epidemiologic, and molecular malaria research. Project Number: 1U19AI089674 (PI: Rosenthal) Dates: 7/10-6/17 Source: NIH/NIAID (Portion of International Centers of Excellence for Malaria Research: Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda. PI: Dorsey, G) Title: Surveillance and discovery mediators of resistance to antimalarial drugs and insecticides & Lab Core Major goals: (1) To compare the prevalence of molecular markers of antimalarial drug. (2) To compare the prevalence of molecular markers of insecticide. (3) To improve surveillance tools and search for novel mediators of antimalarial and insecticide. Project Number: 1R01AI095324 (PI: Rosenthal) Dates: 4/12-3/17 Source: NIH/NIAID Title: Discovery of Oxaboroles as New Antimalarial Agents. Major goals: (1) Hit-to-lead discovery of oxaborole antimalarials. (2) Lead optimization of oxaborole antimalarials. (3) Characterization of the mechansism of action and resistance for lead oxaboroles. Project Number: Not applicable (PI: Rosenthal) Dates: 1/13-1/15 Source: UCSF Research Evaluation and Allocation Committee Title: Etiology of non-malarial febrile illnesses in Ugandan children. Major goals: (1) To characterize the clinical presentations of Ugandan children admitted to a rural hospital with fever. (2) To use deep sequencing to characterize the microbiomes of these children. Project Number: Not applicable (PI: Rosenthal) Dates: 7/13-12/14 Source: Doris Duke Charitable Foundation Clinical Research Mentorship Title: Etiology of non-malarial febrile illnesses in Ugandan children. Major goals: (1) To characterize the clinical presentations of Ugandan children admitted to Tororo District Hospital with fever. (2) To search for associations between specific clinical syndromes and the identification of known and novel pathogens in clinical samples.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Rutherford, George W., M.D., M.A. Salvatore Pablo Lucia Professor, Vice Chair and Head, Division of Infectious Disease Epidemiology, Deaprtment of eRA COMMONS USER NAME Epidemiology and Biostatistics GRUTHERFORD EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Stanford University, Stanford, CA A.B., B.S. 1970-75 Classics, Chemistry Stanford University, Stanford, CA M.A. 1974-75 History Duke University, Durham, NC M.D. 1975-78 Medicine

A. Personal Statement The purpose of this proposal is to establish a premier doctoral program in global health that will guide and contribute to the knowledge base of this emerging discipline. I teach and mentor masters and doctoral students in infectious disease epidemiology and global public health policy both at UCSF and at the University of California, Berkeley. B. Positions and Honors Positions and Employment 1978-80 Intern and Resident, Department of Pediatrics, University of California, San Diego, San Diego, CA 1980-81 Resident, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON 1981-82 Chief Resident, Department of Pediatrics, University of California, San Diego, San Diego, CA 1982-84 Epidemic Intelligence Service (EIS) Officer, Division of Viral Diseases, (1982-3); Division of Field Services (1983-4, assigned to the New York City Department of Health), CDC, Atlanta, GA 1983-85 Director, Division of Immunization, and Acting Director, Division of Tropical Diseases, Bureau of Preventable Diseases, New York City Department of Health, New York, NY 1984-87 Medical Epidemiologist, Epidemiology Program Office (1984-5, assigned to New York City Department of Health); Medical Epidemiologist, AIDS Program, Center for Infectious Diseases (1985-7, assigned to San Francisco Department of Public Health), Centers for Disease Control, Atlanta, GA 1985-90 Chief, AIDS Division, Bureau of Communicable Disease Control (1985-6); Medical Director (1986-8) and Director (1988-90), AIDS Office, San Francisco Department of Public Health, San Francisco, CA 1990-95 Chief, Infectious Disease Branch (1990-2); State Epidemiologist (1990-5); Deputy Director, Prevention Services (1992-5); State Health Officer (1993-5), California Department of Health Services, Berkeley, CA 1995-97 Associate Dean for Administration (1995-7), Professor of Epidemiology and Health Administration (1995-now), School of Public Health, University of California, Berkeley, Berkeley, CA 1997-now Salvatore Pablo Lucia Professor of Preventive Medicine, Epidemiology and Pediatrics; Head, Division of Infectious Disease Epidemiology, and Vice Chair, Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 2002-14 Director, Institute for Global Health, University of California, San Francisco, San Francisco, CA 2010-now Head, Prevention and Public Health Group, UCSF Global Health Sciences Other Experience and Professional Memberships 1996-now Director, Joint UCB-UCSF Residency Program in General Preventive Medicine and Public Health 1997-now Coordinating Editor, Cochrane Collaborative Review Group on HIV Infection and AIDS 2000-03 U.S. Department of Veterans Affairs, National Research Advisory Council (chair) 2004-08 American Academy of Pediatrics, Section on Epidemiology (chair) 2003-04 Institute of Medicine, Committee on the Ryan White Care Act 2004-05 Institute of Medicine, Committee on HIVNET 012 2005-06 Institute of Medicine, Committee on Gulf War and Health: Review of the Medical Literature Relative to Gulf War Veterans’ Health 2007-08 Institute of Medicine, Committee on Methodologic Challenges in HIV Prevention Trials 2007-08 Institute of Medicine, Committee on Gulf War and Health: Traumatic Brain Injury (Chair) 2008-12 Institute of Medicine, Board on Population Health and Public Health Practice 2009-13 Institute of Medicine, Committee on Readjustment Needs of Returning Veterans (Chair) 2010-14 National Institute of Child Health and Human Development Advisory Council 2011-14 Institute of Medicine, Board on the Health of Select Populations Honors 1998 Distinguished Alumnus Award, The Bishop’s School, La Jolla, CA 2000 Eileen K. Taw, M.D., Memorial Public Health Lecturer, Riverside County Department of Public Health, CA

2000 Excellence in Teaching Award, California Department of Health Services Preventive Medicine Program 2000 Salvatore Pablo Lucia Symposium Lecturer, University of California, San Francisco 2002 Excellence in Research Award (Clinical), Children’s Hospital Oakland Research Institute 2002 F. Marian Bishop Educator of the Year Award, Association of Teachers of Preventive Medicine 2009 Holly Smith Award for Exceptional Service to the School of Medicine, UCSF C. Selected Peer-Reviewed Publications (Selected from 163 peer-reviewed publications) Most relevant to current application 1. Raymond HF, Kajubi P, Kamya MR, Rutherford GW, Mandel JS, McFarland W. Correlates of unprotected receptive anal intercourse among gay and bisexual men: Kampala, Uganda. AIDS Behav 2009; 13:677-81. PMID: 19495955 2. Were W, Moore D, Ekwaru P, Mwima G, Bunnell R, Kaharuza F, Rutherford G, Mermin J. A simple screening tool for active tuberculosis in HIV-infected people attending an antiretroviral treatment program in rural Uganda. Int J Tuberc Lung Dis 2009; 13:47-53. PMID: 19105878 3. Gupta R, Dandu M, Packel L, Rutherford G, Leiter K, Phaladze N, Percy-de Korte F, Iacopino V, Weiser SD. Depression and HIV in Botswana: a population-based study on gender-specific socioeconomic and behavioral correlates. PLoS ONE 2010; 5(12):e14252. PMID 21170384 4. Rutherford GW, McFarland W, Spindler H, White K, Patel SV, Aberle-Grasse J, Sabin K, Smith N, Taché S, Calleja-Garcia JM, Stoneburner RL. Public health triangulation: approach and application to synthesizing data to understand national and local HIV epidemics. BMC Public Health 2010; 10:447. PMID 20670448 5. Stanley CM, Rutherford GW, Morshed S, Coughlin RR, Beyeza T. Estimating the health care burden of osteomyelitis in Uganda. Trans R Soc Trop Med Hyg 2010; 104:139-42. PMID: 19709706 6. Butler LM, Were WA, Balinandi S, Downing R, Neilands TB, Gupta S, Rutherford GW, Mermin J. Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda. J Infect Dis 2011; 203:625-34. PMID: 21273188 7. Aluzimbi G, Barker J, King R, Rutherford G, Ssenkusu JM, Lubwama G, Muyonga M, Hladik W, Crane Survey Group. Unplanned sex among university students in Kampala Uganda: a qualitative study of risk factors for HIV/STD and pregnancy. Intl J Adol Youth 2012; doi: 10.1080/02673843.2012.685947. 8. Mudany M, Nduati R, Ngacha D, Rutherford GW. Perceptions of child discipline and its contributions to child abuse in a low-income community in Nairobi, Kenya. Paed Int Child Health 2013; 33:228-32. PMID 24090542 9. Rutherford GW, Anglemyer A, Bagenda D, Muyonga M, Lindan CP, Barker JL, Johnston L, Hladik W. CRANE Study Group. University students and risk of HIV and other sexually transmitted infections in Uganda: the CRANE Survey. Int J Adol Med Health (in press). 10. Anglemyer A, Rutherford GW, Easterbrook PJ, Horvath T, Vitória M, Jan M, Doherty M. Early initiation of antiretroviral therapy for adults and adolescents with HIV-1 infection: a systematic review. AIDS 2014 (in press). 11. Galbraith J, Ochieng A, Mwalili S, Emusu D, Mwandi Z, Kim A, Rutherford G, Maina W, Kimanga D, Chesang K, Cherutich P. Status of voluntary medical male circumcision in Kenya: findings from two nationally- representative surveys in Kenya, 2007 and 2012. J Acquir Immune Defic Syndr (in press). 12. Maina WK, Kim AA, Rutherford GW, Akhwale W, Obudho M, Haper M, Orago A, K’Ogyugi BO, Sharif S, Muraguri N, De Cock K. Kenya AIDS Indicator Surveys 2007 and 2012: Implications to public health policies for HIV prevention and treatment. J Acquir Immune Defic Syndr (in press). 13. Mwendo EM, Mtuy T, Renju J, Rutherford GW, Nondi J, Sichalwe AW, Todd J. Effectiveness of prevention of mother-to-child transmission programs in Kilimanjaro region, northern Tanzania. Trop Med Int Health 2014 Jan 6 [Epub ahead of print]. PMID: 24386998 14. Ng’eno B, Mwangi A, Nganga L, Waruru A, Kimganga D, Mukui I, Kim AA, DeCock K, Maina W, Rutherford GW. HIV infection and coverage of HIV care and treatment among children 18 months to 14 years old in Kenya: results from a nationally representative population based cross-sectional survey. J Acquir Immune Defic Syndr (in press). 15. Rutherford GW, Anglemyer A, Easterbrook PJ, Horvath T, Vitória M, Penazzato M, Doherty M. Predicting treatment failure in adults and children on antiretroviral therapy: a systematic review of the performance characteristics of the World Health Organization’s 2010 criteria for virological failure. AIDS 2014 (in press). 16. Sirengo M, Muthoni L, Kellogg TA, Kim A, Mwanyumba S, Kimanga D, Muraguri N, Elly B, Maina W, Rutherford GW. Mother to child transmission (MTCT) of HIV in Kenya: results from a nationally representative study. J Acquir Immune Defic Syndr (in press).

NAME POSITION TITLE Dean Schillinger, MD Professor of Medicine, eRA COMMONS USER NAME (credential, e.g., agency login) University of California School of Medicine (UCSF) Schillinger EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Russian Language and Brown University BA 06/86 Literature University of Pennsylvania, Philadelphia, PA MD 06/91 Medicine UC San Francisco, SF General Hospital, SF, CA Resident 1991-94 Internal Medicine Chief UC San Francisco, SF General Hospital, SF, CA 1994-95 Internal Medicine Resident UCSF Department of Epidemiology and Advanced Clinical 2002-03 Biostatistics Research Scholar

A. Personal Statement of Qualification Dean Schillinger MD is a general internist and primary care physician and Chief of the UCSF Division of General Internal Medicine at San Francisco General Hospital. An international research expert on health communication and chronic diseases, he founded the UCSF Center for Vulnerable Populations, and currently directs its Health Communications Research Program. Dr. Schillinger served a 5 year term as Chief Medical Officer for the Diabetes Prevention and Control Program for California from 2008-13. He previously directed the ambulatory care clinics at SFGH. He has focused his research on health communication for vulnerable populations, carrying out a number of studies exploring the impact of limited health literacy on the care of patients with diabetes and heart disease. He has been awarded research grants from NHLBI, NIDDK, AHRQ, CDC, PCORI and private foundations, including support to develop and evaluate care management programs tailored to the literacy and language needs of patients with chronic disease, such as diabetes, atrial fibrillation and heart failure. He has published over 160 peer-reviewed scientific articles in the field of health communication science and chronic disease prevention and control. Dr. Schillinger contributed to the 2004 IOM Report on Health Literacy and authored a 2012 IOM publication defining the attributes of Health Literate Healthcare Organizations. He was honored with the 2003 Institute for Healthcare Advancement Research Award, the 2008 Research Award in Safety and Quality from the National Patient Safety Foundation and the Bay Area Research Mentor of the Year Award in 2010. Most recently, he helped California garner a CMS grant to provide incentives to reduce tobacco consumption among Medicaid beneficiaries, and he co-founded the AHRQ-supported California Association of Public Hospital Systems Evidence Network and Innovations Exchange, known as PHoENIX. Dr. Schillinger has also co-created a youth-led diabetes prevention social media campaign called The Bigger Picture, http://youthspeaks.org/thebiggerpicture/. In 2013, he received the prestigious Everett M Rogers Award from APHA in recognition of his outstanding contributions to advancing the study and practice of public health communication.

B. Positions and Honors 1995-2002 Assistant Professor, UCSF Division of General Internal Medicine 1995-8 Medical Director, General Medical Clinic, SFGH 1998-2001 Medical Director, Clinical Operations SFGH Department of Medicine 1999-2000 Acting Chief, UCSF/SFGH Division of General Internal Medicine 2001-3 Coordinator, SGIM Health Literacy Research Interest Group 2002-4 Physician Advocacy Fellow, California Literacy PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page 2003-4 Scientific Advisory Board, ACP Health Communication Initiative 1995-present Faculty, UCSF Primary Care Research Center, Medical Effectiveness Research Center 2002-present Associate Professor of Medicine, UCSF Division of General Internal Medicine 2006 Visiting Scholar (1 semester), University of Chile School of Public Health, Santiago, Chile 2006-2011 Director, UCSF Center for Vulnerable Populations 2008-present Professor of Medicine in Residence, UCSF Department of Medicine 2008-present Chief, Diabetes Prevention and Control Program, California Dept of Public Health 2009-11 Interim Chief, UCSF/SFGH Division of General Internal Medicine 2011-present Chief, UCSF/SFGH Division of General Internal Medicine 2011-present Director, UCSF Center for Vulnerable Populations Health Communications Program Honors 2000-01 Fellow, US Public Health Service Primary Care Policy Fellowship, Washington, DC 2001 Reviewer, Institute of Medicine Report on Insurance, Access, and Health 2003 Outstanding Researcher of the Year Award, Institute for Health Care Advancement 2003 Reviewer, AHRQ Evidence-Based Review of Literacy and Health 2004 Contributing Author, Institute of Medicine Report on Health Literacy 2004 Research/Service Award, National Association of Public Hospitals 2005 SFGH Representative, AMA Ethical Force Award, Innovations in Health Communication 2005 Outstanding Research Paper of the Year Award, Society Teachers of Family Medicine 2005-6 Participant, JCAHO Policy Roundtable on Literacy and Patient Safety 2006 Participant, Surgeon General Workshop on Improving Health Literacy 2008 Advancing Patient Safety Research Award in Health Literacy 2009 George Engel Career Research Award, Am. Assn Communication in Healthcare 2010 CDC/NIH National Diabetes Education Program Frank Vinicor Award 2010 Outstanding Mentor in Clinical Research, Bay Area Clinical Research Symposium 2011 Author, Commissioned IOM Report on Attributes of Health Literate healthcare Organizations 2012-14 Member, Strategic Planning Task Group, National Diabetes Education Program, NIDDK & CDC 2013 APHA Everett M Rogers Award

C. Selected Peer-reviewed Publications (Selected from 161 peer-reviewed publications) 1. Hyman A, Schillinger D, Lo B. Laws Mandating Reporting of Domestic Violence: Do They Promote Patient Well-Being? JAMA. 1995;273:1781-1787. 2. Osmond D, Vranizan K, Schillinger D, Stewart A, Bindman A. Measuring the Need for Care in an Ethnically Diverse Population. Health Services Research. 1996;31: 551-571 3. Schillinger D. The Disability Blues. JAMA. 1998;279:15 4. Schillinger D, Ofman D. Medication Dispensing and Medicaid Managed Care. JAMA. 1998;279:912-3 (correspondence). 5. Schillinger D, Hyman A. In Opposition to Mandatory Reporting, in California’s mandatory reporting of domestic violence Issues: Does the law go too far or not far enough? West J Med. August 1999;171:121- 123. 6. Schillinger D, Bibbins-Domingo K, Vranizan K, Luce J, Bindman A. The Effects of Primary Care Coordination on Public Hospital Patients. J Gen Int Med. 2000;15:329-336. 7. Schillinger D, Wheeler M, Fernandez A. Training Agents of Change: The Populations and Quality Improvement Seminar for Medical Residents at San Francisco General Hospital. Academic Medicine. 2000;75:562-3. 8. Schillinger, D. Improving the Quality of Chronic Disease Management for Populations with Low Functional Health Literacy. Disease Management. September 2001;4:103-110. 9. Walter N, Bourgois P, Loinaz, HM, Schillinger D. Desperation on Cesar Chavez Street: Social Context of Work Injury Among Undocumented Day Laborers in San Francisco. JGIM. March 2002;17(3):221-9. 10. Schillinger D, Wang F, Grumbach K, Daher C, Palacios J, Diaz-Sullivan G, Piette J, Bindman AB. Association of Functional Health Literacy with Glycemic Control among Diabetes Patients. JAMA. 2002;288:475-482. PHS 398/2590 (Rev. 06/09) Page 2 Continuation Format Page 11. Schillinger D, Piette J, Grumbach K, Wang F, Wilson C, Daher C, Leong-Grotz K, Castro C, Bindman A. Closing the Loop: Physician-Patient Communication with Diabetic Patients Who Have Low Health Literacy. Arch Int Med. January 13, 2003;163:83-90. 12. Piette J, Schillinger D, Potter M, Heisler M. Dimensions of Patient-Provider Communication and Diabetes Self-Care in an Ethnically-Diverse Patient Population. JGIM. August 2003;18:624-33. 13. Youmans S, Schillinger D. Functional Health Literacy and Medication Management: The Role of the Pharmacist. Ann of Pharmacother. November 2003;37:1726-1730. 14. Schillinger D, Wilson C, Bindman A. In Reply (correspondence). “Who Actually Has the Low Health Literacy”. Arch Int Med. July 28, 2003;163:1746. 15. Kusec S, Brborovic O, Schillinger D. Diabetes Websites Accredited by the Health on the Net Foundation Code of Conduct: Readable or Not? Studies in Health Technology and Informatics. Vol 95. The New Navigators: from Professionals to Patients. Edited by: R. Baud , M. Fieschi , P. Le Beux and P. Ruch. 2003. 16. Schillinger D, Bindman A, Stewart A, Wang F, Piette J. Health Literacy and the Quality of Physician- Patient Interpersonal Communication. Patient Educ and Couns. 2004;3:315-323. 17. Fernandez A, Schillinger D, Grumbach K, Rosenthal A, Wang F, Perez-Stable E. Physician Spanish Language Ability and Cultural Competence: An Exploratory Study of Communication with Spanish- speaking Patients. J Gen Int Med. 2004;19:167-174. 18. Piette J, Wagner T, Potter M, Schillinger D. Health Insurance Status, Cost-related Underuse, and Outcomes Among Diabetes Patients in Three Systems of Care. Medical Care. 2004;42:102-9. 19. Schillinger D, Chen A. Literacy and Language: Disentangling Measures of Access, Utilization and Quality. J Gen Int Med. 2004;19:288-290. 20. Walter N, Schillinger D. Frontline Bureaucracies and the Moral Mechanics of US Health Care. Medical Care. March 2004;42:303-305. 21. Schillinger D. Health Literacy and Error Reduction: A Fatal Aspiration of a Syringe Cap. AHRQ Morbidity and Mortality Rounds on the Web. April 2004: http://webmm.ahrq.gov/ 22. Schillinger D. Improving Chronic Illness Care for Populations with Limited Health Literacy, in Health Literacy: a Prescription to End Confusion. National Academy of Sciences Press. April 2004;269-86 (commissioned paper for the Institute of Medicine). 23. Cohan D, Feakins C, Wara D, Petru A, McNicholl I, Schillinger D, Kuritzkes D, Deeks S. Perinatal Transmission of Multidrug Resistant HIV from a Pregnant Woman on Directly-Observed, Enfuvirtide- containing Antiretroviral Therapy with Viral Suppression at Delivery. AIDS. 2005;19:989-994. 24. Schillinger D, Machtinger E, Wang F, Win K, Chen L, Bindman A. Medication Mis- communication and Anticoagulant Care: Are Pictures Worth more Than Words? In AHRQ Peer-reviewed Publication: Henriksen K, Battles J, Lewin DI, Marks E, editors. Advances in patient safety: from research to implementation. Vol. 2, Research findings. Rockville, MD: Agency for Healthcare Research and Quality. 2005:199-211. 25. Schillinger D, Machtinger E, Wang F, Rodriguez M, Bindman A. Preventing Medication Errors in Ambulatory Care: the Importance of Establishing Regimen Concordance. In AHRQ Peer-reviewed Publication: Henriksen K, Battles J, Lewin DI, Marks E, editors. Advances in patient safety: from research to implementation. Vol. 1, Research findings. Rockville, MD: Agency for Healthcare Research and Quality. 2005:199-210. 26. Bhandari V, Kushel M, Price L, Schillinger D. Racial Disparities in Outcomes of Inpatient Stroke Rehabilitation. Archives of Physical Medicine and Rehabilitation. November 2005;86(11):2081-6. 27. Seligman HK, Wang FF, Palacios JL, Wilson CC, Daher C, Piette JD, Schillinger D. Physician notification of their diabetes patients' limited health literacy. A randomized, controlled trial. J Gen Intern Med. 2005 Nov;20(11):1001-7. 28. Handley M, Hammer H, Schillinger D. Navigating the Terrain Between Research and Practice: A Collaborative Research Network Case Study in Diabetes Research. J Am Board Fam Practice. 2006;19:85-92 29. Piette J, Bibbins-Domingo K, Schillinger D. Health Care Discrimination, Processes of Care, and Diabetes Patients’ Health Status. Patient Educ Couns. January 2006;60(1):41-8.

PHS 398/2590 (Rev. 06/09) Page 3 Continuation Format Page 30. Saba G, Wong ST, Schillinger D, Fernandez A, Somkin CP, Wilson C, Grumbach K. Shared Decision Making and the Experience of Partnership in Primary Care. Ann Fam Med. January-February 2006;4(1):54-62. 31. Schillinger D, Barton L, Karter A, Wang F, Adler N. Does Literacy Mediate the Relationship Between Education and Health Outcomes? A Study of a Low -Income Population with Diabetes. Pub Health Rep. 2006;121(3):245-54. 32. Sarkar U, Fisher L, Schillinger D. Is Self-Efficacy Associated with Diabetes Self-Management Across Race/Ethnicity and Health Literacy? Diab Care. April 2006;29(4):823-9 33. MacGregor, Wong S, Osmer C, Handley M, Gjeltema K, Schillinger D, Bodenheimer T. Collaborative Self-Management Goal-Setting Using Action Plans by Primary Care Clinicians and Patients with Coronary Heart Disease Risk Factors. J Am Board Fam Med. 2006;19:215-23. 34. Handley M, MacGregor K, Schillinger D, Sharifi C, Wong S, Bodenheimer T. Using Action Plans to Help Primary Care Patients Adopt Healthy Behaviors: A Descriptive Study. J Am Board Fam Med. 2006;19:224-31. 35. Schillinger D, Machtinger E, Wang F, Rodriguez M, Bindman A. The Importance of Establishing Regimen Concordance in Preventing Medication Errors in Anticoagulant Care. J Health Comm. 2006:11:1-14. 36. Paasche-Orlow MK, Schillinger D, Green SM, Wagner EH. How Healthcare Systems Can Begin to Address the Challenge of Limited Literacy. J Gen Intern Med. August 2006;21(8):884-7. 37. Sudore RL, Landefeld CS, Williams B, Barnes D, Lindquist K, Schillinger D. Use of a Modified Informed Consent Process Among Vulnerable Patients: A Descriptive Study. J Gen Intern Med. August 2006;21(8):867-73. 38. Sudore RL, Yaffe K, Satterfield S, Harris T, Mehta K, Simonsick E, Newman A, Rosano C, Rooks R, Rubin S, Ayonayon H, Schillinger D. Limited Literacy and Mortality in the Elderly: the health, aging, and body composition study. J Gen Intern Med. August 2006;21(8):806-12. 39. Fang M, Machtinger EL, Wang F, Schillinger D. Health Literacy and Anticoagulation-Related Outcomes Among Patients Taking Warfarin. J Gen Intern Med. August 2006;21(8):841-6. 40. Schillinger D. Patagonia Pastorale. JAMA. 2006;296(13):1567-8. 41. Schillinger D, Machtinger EL, Wang F, Palacios J, Rodriguez M, Bindman A. Language, Literacy, and Communication Regarding Medication in an Anticoagulation Clinic: A Comparison of Verbal vs. Visual Assessment. J Health Commun. October-November 2006;11(7):651-64. 42. Schillinger D. Misunderstanding Prescription Labels: The Genie is Out of the Bottle. Ann Int Med. December 19, 2006; 145(12):926-8. Epub Nov 29, 2006. 43. Seligman H, Wallace A, DeWalt D, Schillinger D, Arnold C, Shilliday BB, Delgadillo A, Bengal N, Davis T. Facilitating Behavior Change With Low-Literacy Patient Education Materials. Am J Health Behav. 2007;31(Suppl 1):S69-S78. 44. Castro C, Wilson C, Wang F, Schillinger D. Babel Babble: Physicians' Use of Jargon with Diabetes Patients. Am J Health Beh. 2007;31(Suppl 1):S85-S95. 45. Goldman L, Handley M, Rundall T, Schillinger D. Current and Future Directions in MediCal Chronic Disease Care Management: A View from the Top. Am J Managed Care. May 2007; 13(5):263-8. 46. Youmans SL, Schillinger D, Mamary E, Stewart A. African-Americans’ Perceptions of Pharmacists. Ethnicity and Disease. 2007;17:284-290. 47. Machtinger E, Wang F, Chen L, Rodríguez M, Wu S, Schillinger D. A Visual Medication Schedule to Improve Anticoagulant Care: A Randomized Controlled Trial. Joint Commission Journal of Quality and Patient Safety. October 2007;33(10)625-635. 48. Schillinger D, Hammer H, Wang F, McLean I, Tang A, Youmans S, Handley M. Seeing in 3-D: Examining the Reach of Diabetes Self-Management Support Strategies in a Public Healthcare System. Health Ed Behav. 2008 Oct;35(5):664-82. Epub 2007 May 18. 49. Schillinger D. Literacy and Health Communication: Reversing the Inverse Care Law. Am J Bioeth. November 2007;7(11):15-18. 50. Sudore RL, Landefeld CS, Barnes DE, Lindquist K, Williams BA, Brody R, Schillinger D. An Advance Directive Redesigned to Meet the Literacy Level of Most Adults: A Randomized Trial. Pt Ed Counsel. December 2007;69(1-3):165-95.

PHS 398/2590 (Rev. 06/09) Page 4 Continuation Format Page 51. Sarkar U, Piette JD, Gonzales R, Lessler D, Chew LD, Reilly B, Johnson J, Brunt M, Huang J, Regenstein M, Schillinger D. Preferences for Self-Management Support: Findings from a Survey of Diabetes Patients in Safety-Net Health Systems. Pt Ed Counsel. 2008 Jan;70(1):102-10 52. Bhandari V, Wang F, Bindman A, Schillinger D. Quality of Anticoagulation Control in a Public Hospital System: Do Race and Language Matter? J Health Poor Underserved. 2008; 19:41-55. 53. Sarkar U, Handley MA, Gupta R, Tang A, Murphy E, Seligman HK, Shojania KG, Schillinger D. Use of an interactive, telephone-based self-management support program to identify adverse events among ambulatory diabetes patients. J Gen Intern Med. 2008 Apr;23(4):459-65. PMCID: PMC2359521. 54. Swenson S, Stewart A, Schillinger D. The Influence of Depressive symptoms on Clinician–Related Communication Among Patients With Type 2 Diabetes. Med Care. 2008 Mar;46(3):257-65. 55. Moffet HH, Adler N, Schillinger D, Ahmed AT, Laraia B, Selby J, Neugebauer R, Liu J, Parker MM, Warton M, Karter A. Cohort Profile: The Diabetes Study of Northern California (DISTANCE). Int J Epidemiol. 2009 Feb;38(1):38-47. Epub 2008 March 7. 56. Sudore RL, Schickedanz A, Landefeld CS, Williams BA, Lindquist K, Pantilat SZ, Schillinger D. Engagement in the Multiple Steps of Advance Care Planning: A Descriptive Study Among Diverse Older Adults. J Am Ger Society. 2008 Jun;56(6):1006-13. Epub 2008 Apr 10. 57. Schillinger D. Genetics of Warfarin response. N Engl J Med. 2008 Jun 19;358(25):2741-2; author reply 2743-4. (correspondence) 58. Schillinger D, Dohan D. Genetic testing for vulnerable populations: What kind of communications we need and don’t. Am J Bioethics. 2008 Jun;8(6):12-4. 59. Sudore RL, Landefeld CS, Schillinger D. Reach and Impact of a Mass Media Event Among Vulnerable Patients: The Terri Schiavo Story. J Gen Int Med. 2008 Nov;23(11):1854-7. 60. Karliner LS, Napoles-Springer A, Schillinger D, Bibbins-Domingo K, Peréz-Stable EJ. Identification of Limited English Proficient Patients in Clinical Care. J Gen Intern Med. 2008 Oct;23(10):1555-60 61. Sarkar U, Schillinger D. Does Lower Diabetes-related Numeracy Lead to Increased Risk for Hypoglycemic Events? Ann Int Med. 2008 Oct 21;149:549; author reply 594. 62. Chew L, Schillinger D, Maynard C, et al. Glycemic and Lipid Control among Patients with Diabetes at Six U.S. Public Hospitals. J Health Poor Underserved. 2008 Nov;19(4):1060-75. 63. Handley M, Shumway M, Schillinger D. Cost-Effectiveness of Automated Telephone Self-Management Support with Nurse Care Management Among Patients with Diabetes. Ann Fam Med. 2008 Nov- Dec;6(6):512-8. PMCID: PMC2582479. 64. Schickedanz A, Schillinger D, Landefeld S, Knight S, Williams B, Sudore R. A Clinical Framework for Improving the Advance Care Planning Process: Start with Patients’ Self-identified Barriers. J Am Geriatr Soc. 2009 Jan;57(1):31-9. 65. Schillinger D, Handley M, Wang F, Hammer H. Effects Of Self-Management Support On Structure, Process And Outcomes Among Vulnerable Patients With Diabetes: A 3-Arm Practical Clinical Trial. Diabetes Care. 2009 Apr;32(4):559-66. Epub 2009 Jan 8. PMCID: PMC2660485. 66. Wallace A, Seligman H, Davis T, Schillinger D, Arnold C, Bryant-Shilliday B, Freburger J, DeWalt D. Literacy Appropriate Educational Materials and Brief Counseling Improves Diabetes Self-Management. Patient Educ Couns. 2009 Jun;75(3):328-33. Epub 2009 Jan 23. 67. Fang M, Panguluri P, Machtinger EL, Schillinger D. Language, Literacy, and Characterizations of Stroke Among Patients Taking Warfarin for Stroke Prevention: Implications for Health Communication. Pat Ed Counsel. 2009 Jun;75(3):403-10. Epub 2009 Jan 25. 68. Tache S, Schillinger D. Health Worker Migration: Time for the Global Justice Approach. Am J Bioeth. 2009 Mar;9(3):12-14. 69. DeWalt DA, Broucksou KA, Hawk V, Baker DW, Schillinger D, Ruo B, Bibbins-Domingo K, Holmes M, Weinberger M, Macabasco-Connell A, Pignone M. Comparison of a One-Time Educational Intervention to a Teach-to-Goal Educational Intervention for Self-Management of Heart Failure: Design of a Randomized Controlled Trial. BMC Health Serv Res. 2009 June 11;9(1)99. 70. Sarkar U, Wachter R, Schroeder S, Schillinger D. Refocusing the Lens: Patient Safety in Ambulatory Chronic Disease Care. Jt Comm J Qual Saf. 2009 Jul;35(7):377-83. 71. Sudore RL, Landefeld CS, Pérez-Stable EJ, Bibbins-Domingo K, Williams BA, Schillinger D. Unraveling the relationship between literacy, language proficiency, and patient-physician communication. Patient Educ Couns. 2009 Jun;75(3):398-402. Epub 2009 May 12. PHS 398/2590 (Rev. 06/09) Page 5 Continuation Format Page 72. Schillinger D, Sarkar U. Numbers Don’t Lie, But Do They Tell the Whole Story? Diab Care. 2009 Sep;32(9):1746-7. 73. DeWalt D, Davis T, Wallace A, Seligman H, Bryant-Shilliday B, Arnold CL, Schillinger D. Goal Setting in Diabetes Self-Management: Taking the Baby Steps to Success. Patient Educ Couns. 2009 Nov;77(2):218-23. Epub 2009 Apr 8. 74. Kim Y, Situ M, Handley M, McLean I, Schillinger D. Ecology Matters: Patient Perspectives Of Diabetes Self-Management Support Strategies in a Safety-Net Health System. Asia Pacific Journal of General Practice. 2009 Oct;1(1)1-10. Epub 05 November 2009. 75. Barton J, Criswell L, Kaiser R, Chen Y, Schillinger D. A Systematic Review and Meta-Analysis of Patient Self-Report vs. Trained Assessor Joint Counts in Rheumatoid Arthritis. J Rheumatol. 2009 Dec;36(12):2635-41. Epub 2009 Nov 16. 76. Steinman MA, Schillinger D. Drug Detailing in Academic Medical Centers: Regulating for the Right Reasons, with the Right Evidence, at the Right Time (Editorial). Am J Bioeth. 2010 Jan;10(1):21-3. 77. Sudore R, Schillinger D. Interventions to Improve Care for Patients with Limited Health Literacy. J Clin Outcomes Manag. 2010 Jan;16(1):20-9. 78. He G, Sentell T, Schillinger D. A New Public Health Tool for Abnormal Glucose Risk Assessment: The AGRA-6. Prev Chronic Disease. 2010 Mar;7(2):A34. Epub 2010 Mar 15. PMCID: PMC2831788. 79. Moffet HH, Schillinger D, Weintraub JA, Adler N, Liu JY, Selby JV, Karter AJ. Social Disparities in Dental Insurance and Annual Dental Visits among Medically Insured Patients with Diabetes: The Diabetes Study of Northern California (DISTANCE) Survey. Prev Chronic Dis. 2010 May;7(3):A57. Epub 2010 May 15. 80. Barton J, Yelin E, Criswell L, Imboden J, Graf J, Schillinger D . Patient – Physician Discordance in Assessments of Global Disease Severity in Rheumatoid Arthritis. Arthritis Care & Research. 2010 June; 62(6):857-64. 81. Sarkar U, Handley M, Gupta R, Tang A, Shojainia K, Schillinger D. What Happens Between Visits? Adverse and Potential Adverse Events Among a Low-Income, Urban, Ambulatory Population with Diabetes. Qual Safety Health Care. 2010 Jun;19(3):223-8. Epub 2010 Apr 8. 82. Sarkar U, Karter A , Moffet H, Adler N, Liu J, Schillinger D, Hypoglycemia Among Patients with Type 2 Diabetes in The Diabetes Study of Northern California (DISTANCE): The Role of Health Literacy. J Gen Int Med. 2010 Sep;25(9):962-8. Epub 2010 May 18. PMCID: PMC2917655. 83. Vijayaraghavan M, He G, Stoddard P, Schillinger D. Blood Pressure Control, Hypertension, Awareness, and Treatment in Adults with Diabetes in the United States-Mexico Border Region. Rev Panam Salud Publica. 2010 Sep 30;28(3):164-73. 84. Stoddard P, He G, Vijayaraghavan M, Schillinger D. Disparities in Undiagnosed Diabetes Among United States-Mexico Border Populations. Rev Panam Salud Publica. 2010 Sep 30;28(3):198-206. 85. Stoddard P, He G, Schillinger D. Smoking Behavior Among Hispanic Adults with Diabetes on the United States-Mexico Border: A Public Health Opportunity. Rev Panam Salud Publica. 2010 Sep 30;28(3):221- 29. 86. Dehlendorf C, Ruskin R, Grumbach K, Vittinghoff E, Bibbins-Domingo K, Schillinger D, Steinauer J. Recommendations for Intrauterine Contraception: A Randomized Trial of the Effects of Patients’ Race/Ethnicity and Socioeconomic Status. Am J Obstet Gynecol. 2010 Oct;203(4):319.e1-8. Epub 2010 Jul 2. 87. Schenker Y, Fernandez A, Sudore R, Schillinger D. Interventions to Improve Patient Comprehension in Informed Consent for Medical and Surgical Procedures: A Systematic Review. Med Dec Making. 2011 Jan-Feb;31(1):151-73. Epub 2010 Mar 31. Review. 88. McCormack L, Squiers L, Bann C, Berkman N, Squire C, Schillinger D, Ohene-Frempong J, Hibbard J. Measuring Health Literacy: Preliminary Results from a New Skills-Based Instrument. J Heath Comm. 2010;15 Suppl 2:51-71. 89. Sarkar U, Karter AJ, Liu JY, Adler NE, Nguyen R, Lopez A, Schillinger D. The Literacy Divide: Health Literacy and the Use of an Internet-Based Patient Portal in an Integrated Health System - Results from the Diabetes Study of Northern California (DISTANCE). J Health Commun;15(1):183-96. 90. Seligman H, Schillinger D. Hunger and Socioeconomic Disparities in Chronic Disease. New Eng J Med. 2010 Jul 1;363(1):6-9. 91. Sudore R, Schillinger D, Fried T. Uncertainty About Advance Care Planning Treatment Preferences Among Diverse Older Adults. J Health Comm. 2010;15 Suppl 2:159-71. PHS 398/2590 (Rev. 06/09) Page 6 Continuation Format Page 92. Seligman HK, Davis TC, Schillinger D, Wolf MS. Food Insecurity is Associated with Hypoglycemia and Poor Diabetes Self-Management in a Low-Income Sample with Diabetes. J Health Poor Underserved. 2010 Nov;21(4):1227-33. 93. Schenker Y, Karter A, Schillinger D, Warton EM, Adler NE, Moffett HH, Ahmed AT, Fernandez A. The impact of limited English proficiency and physician language concordance on reports of clinical interactions among patients with diabetes: the DISTANCE Study. Patient Educ Couns. 2010 Nov;81(2):222-8. Epub 2010 Mar 11. 94. Fernandez, A, Schillinger D, Wharton EM, Adler N, Moffet HH, Schenker Y, Salgado V, Ahmed A, Karter AJ. Language Barriers, Physician-Patient Language Concordance and Glycemic Control Among Insured Latinos with Diabetes: The Diabetes Study of Northern California (DISTANCE). J Gen Int Med. 2011 Feb;26(2):170-6. Epub 2010 Sep 29. 95. Kanaya A, Adler N, Liu J, Schillinger D, Ahmed A, Moffet H, Karter A. Heterogeneity of Diabetes Outcomes among Asian and Pacific Islanders in the US: The DISTANCE Study. Diab Care. 2011 Apr;34(4):930-7. Epub 2011 Feb 24. 96. Sarkar U, Schillinger D, Lopez A, Sudore R. Validation of Self-Reported Health Literacy Questions Among Diverse English and Spanish-speaking Populations. J Gen Int Med. 2011 Mar;26(3):265-71. Epub 2010 Nov 6. 97. Sarkar U, Karter AJ, Liu JY, Nguyen R, Lopez A, Schillinger D. Social Disparities in Internet Patient Portal Use in Diabetes: Evidence that the Digital Divide Extends Beyond Access. J Am Med Inform Assoc. 2011 May 1;18(3):318-21. Epub 2011 Jan 24. 98. Moffet H, Parker MM, Sarkar U, Schillinger D, Fernandez A, Adler N, Karter AJ. Adherence to lab requests by patients with diabetes: The Diabetes Study of Northern California (DISTANCE). Am J Managed Care. 2011;17(5):339-44. 99. Lyles CR, Karter AJ, Young BA, Clarence S, Grembowski D, Schillinger D, Adler N. Correlates of Self- Reported Racial/Ethnic Healthcare Discrimination in the Diabetes Study of Northern California (DISTANCE). J Health Poor Underserved. 2011;22(1):211-25. 100. Rosenthal A, Wang F, Schillinger D, Perez-Stable E, Fernandez A. Accuracy of Physician Self-report of Spanish Language Proficiency. J Immigr Minor Health. 2011 Apr;13(2):239-43. 101. Lyles CR, Karter AJ, Young BA, Clarence S, Grembowski D, Schillinger D, Adler N. Patient-Reported Racial/Ethnic Healthcare Discrimination and Medication Intensification in the Diabetes Study of Northern California (DISTANCE). J Gen Intern Med. 2011 May 6;26(10):1138-44). [Epub ahead of print]. 102. Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner M, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E. Racial and Ethnic Disparities in Disease Activity and Function among Persons with Rheumatoid Arthritis from University-Affiliated Clinics. Arthritis Care Res (Hoboken). 2011 Jun 13. doi: 10.1002/acr.20525. [Epub ahead of print]. 103. Sarkar U, Schillinger D, Bibbins-Domingo K, Nápoles A, Karliner L, Pérez-Stable EJ. Patient-Physicians’ Information Exchange in Outpatient Cardiac Care: Time for a Heart to Heart? Patient Educ Couns. 2011 Nov;85(2):173-9. Epub 2010 Oct 28. 104. Lyles CR, Karter AJ, Young BA, Clarence S, Grembowski D, Schillinger D, Adler N. Provider Factors and Patient-Reported Healthcare Discrimination in the Diabetes Study of California (DISTANCE). Patient Ed Counsel. 2011 Dec;85(3):e216-24. Epub 2011 May 24. 105. Moskowitz D, Lyles CR, Karter AJ, Adler N, Moffet HH, Schillinger D. Patient reported interpersonal processes of care and perceived social position: the Diabetes Study of Northern California (DISTANCE). Patient Educ Couns. 2011 Aug 18. [Epub ahead of print] 106. Laiteerapong N, Karter A, Liu J, Moffet H, Sudore R, Schillinger D, John J, Huang E. Correlates of Quality-of-Life in Older Adults with Diabetes: The Diabetes & Aging Study. Diabetes Care. 2011 Jun 2. [Epub ahead of print]. 107. Sarkar U, López A, Black K, Schillinger D. The Wrong Tool for the Job? Diabetes Public Health Programs and Practice Guidelines. Am J Public Health. 2011 Aug 18. [Epub ahead of print]. 108. Schillinger D. Supporting Self-Management. Patient Educ and Couns. 2011 Sep 1. [Epub ahead of print]. 109. Handley M, Schillinger D. Quasi-Experimental Designs in Practice Based Research Settings: Design and Implementation Considerations. J Am Board Fam Practice. 2011 Sep-Oct;24(5):589-96.

PHS 398/2590 (Rev. 06/09) Page 7 Continuation Format Page 110. Macabasco-O’Connell A, DeWalt DA, Broucksou KA, Hawk V, Baker DW, Schillinger D, Ruo B, Bibbins- Domingo K, Holmes M, Erman B, Weinberger M, Pignone M. Relationship between literacy, knowledge, self-care behaviors, and symptoms among patients with heart failure. J Gen Int Med. 2011 Sep;26(9):979-86. Epub 2011 Mar 3. 111. Baker DW, DeWalt DA, Schillinger D, Hawk V, Ruo B, Bibbins-Domingo K, Weinberger M, Macabasco- O'Connell A, Pignone M. “Teach to Goal”: Theory and Design Principles of an Intervention to Improve Heart Failure Self-Management Skills of Patients with Low Health Literacy. J Health Commun. 2011 Sep 30;16 Suppl 3:73-88. 112. Baker DW, Dewalt DA, Schillinger D, Hawk V, Ruo B, Bibbins-Domingo K, Weinberger M, Macabasco- O'Connell A, Grady KL, Holmes GM, Erman B, Broucksou KA, Pignone M. The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms. J Card Fail. 2011 Oct;17(10):789-96. Epub 2011 Jul 23. 113. Choi AI, Karter AJ, Liu J, Young B, Schillinger D. Ethnic Differences in the Development of Albuminuria: The Diabetes Study of Northern California (DISTANCE). Am J Manag Care. 2011;17(11)737-45. 114. Stoddard P, Handley M, Schillinger D. The influence of Indigenous status on diabetes and obesity among Mexican adults. Soc Sci Med. 2011 Dec;73(11):1635-43. Epub 2011 Sep 29. 115. Parker M, Adler N, Schillinger D, Moffet H, Fernandez A, Karter A. Ethnic Differences in Appointment- Keeping in the Diabetes Study of Northern California (DISTANCE). Health Svcs Research. 2011 Oct 27. doi: 10.1111/j.1475-6773.2011.01337.x. [Epub ahead of print] 116. Plantinga L, Johansen K, Schillinger D, Powe NR. Lower Socioeconomic Status and Disability among US Adults with Chronic Kidney Disease, 1999-2008. Prev Chronic Dis. 2012 Jan;9:E12. Epub 2011 Dec 15. 117. Ratanawongsa N, Crosson H, Schillinger D, Karter AJ, SahaCK, Marrero DG. Getting Under the Skin of Clinical Inertia: Primary Care Provider Barriers to Insulin Initiation Among Poorly Controlled Diabetics in The Translating Research Into Action for Diabetes (TRIAD) Insulin Starts Project. Diabetes Educ. 2012 Jan-Feb;38(1):94-100. doi: 10.1177/0145721711432649. Epub 2012 Jan 5.]. 118. Ratanawongsa N, Handley MA, Quan J, Sarkar U, Pfeifer K, Soria C, Schillinger D. Quasi-Experimental Trial of Diabetes Self-Management Automated and Real-Time Telephonic Support (SMARTSteps) in a Medicaid Managed Care Plan: Study Protocol. BMC Health Serv Res. 2012 Jan 26;12:22. 119. Ratanawongsa N, Bhandari V, Handley M, Rundall T, Hammer H, Schillinger D. Primary Care Provider Perceptions of the Effectiveness of Two Self-Management Support Programs for Vulnerable Patients with Diabetes. J Diabetes Sci Technol. 2012;6(1):116-124. 120. Bailey SC, Hasnain-Wynia R, Chen AH, Sarkar U, Lindquist LA, Schillinger D, Wolf MS. Developing Multilingual Prescription Instructions for Patients with Limited English Proficiency. J Health Care Poor and Underserved. 2012 Feb;23(1):81-7. 121. Bailey SC, Sarkar U, Chen A, Schillinger D, Wolf MS. Evaluation of Language Concordant, Patient- Centered Drug Label Instructions. J Gen Int Med. 2012 Dec;27(12):1707-13. doi: 10.1007/s11606-012- 2035-3. Epub 2012 Mar 27. 122. Plantinga L, Rao M, Schillinger D. Prevalence of Self-Reported Sleep Problems among People with Diabetes in the United States, 2005-08. Prev Chronic Dis. 2012 Mar;9:E76. Epub 2012 Mar 22. 123. Karliner LS, Auerbach A, Nápoles A, Schillinger D, Nickleach D, Pérez-Stable EJ. Language Barriers, Inadequate Health Literacy and Understanding of Hospital Discharge Instructions. Med Care. 2012 Apr;50(4):283-9. 124. Laraia BA, Karter AJ, Warton EM, Schillinger D, Moffet HH, Adler NE. Place Matters: Neighborhood Deprivation and Cardiometabolic Risk Factors Among Adults with Diabetes. Soc Sci Med. 2012 Apr;74(7):1082-90. Epub 2012 Jan 28. 125. DeWalt D, Schillinger D, Ruo B, Bibbins-Domingo K, Baker DW, Holmes GM, Weinberger M, Macabasco-O’Connell A, Broucksou K, Hawk V, Erman B, Sueta CA, Chang PP, Cene CW, Wu J, Jones CD, Pignone M. A multisite randomized trial of a single- versus multi-session literacy sensitive self-care intervention for patients with heart failure. Circulation. 2012 Jun 12;125(23):2854-62. doi: 10.1161/CIRCULATIONAHA.111.081745. Epub 2012 May 9.

PHS 398/2590 (Rev. 06/09) Page 8 Continuation Format Page 126. Sentell T, He G, Gregg EW, Schillinger D. Racial/Ethnic Variation in Prevalence Estimates for United States Prediabetes Under Alternative 2010 American Diabetes Association Criteria: 1988-2008.Ethn Dis. 2012 Autumn;22[4]:451–458. 127. Ratanawongsa N, Karter AJ, Parker M, Lyles C, Heisler M, Moffet H, Adler N, Warton EM, Schillinger D. Communication and Medication Refill Adherence: The Diabetes Study of Northern California. Arch Int Med. 2012 Dec 31:1-9. 128. Sudore RL, Karter AJ, Schillinger D. Symptom Burden of Adults with Type-2 Diabetes across the Life Course: Diabetes & Aging Study. J Gen Intern Med. 2012 Dec;27(12):1674-81. doi: 10.1007/s11606-012- 2132-3. Epub 2012 Aug 2. 129. Ratanawongsa N, Karter AJ, Parker M, Lyles C, Heisler M, Moffet H, Adler N, Warton EM, Schillinger D. Communication and Medication Refill Adherence: The Diabetes Study of Northern California. JAMA Intern Med. 2013 Feb 11;173(3):210-8. doi: 10.1001/jamainternmed.2013.1216. 130. Wallace A, Perkhounkova Y, Tseng H, Schillinger D. Influence of patient characteristics on assessment of diabetes self-management support. Nurs Res. 2013 Mar;62(2):106-14. doi: 10.1097/NNR.0b013e3182843b77. 131. Karter AJ, Schillinger D, Adams AS, Moffet HH, Liu J, Adler NE, Kanaya AM. Elevated Rates of Diabetes in Asian and Pacific Islander Subgroups: The Diabetes Study of Northern California (DISTANCE). Diabetes Care. 2013 2013 Mar;36(3)574-9. Doi:10.2337/dc12-0722 Epub 2012 Oct 15. 132. Stoddard P, Laraia B, Warton M, Moffet H, Adler N, Schillinger D, Karter A. Neighborhood Deprivation and Change in BMI among Adults with Type 2 Diabetes: The Diabetes Study of Northern California (DISTANCE). Diabetes Care. 2013 May;36:1200-1208; published ahead of print December 28, 2012, doi:10.2337/dc11-1866 133. Lyles CR, Schillinger D, Lopez A, Handley M, Ratanawogsa N, Sarkar U. Safety Events during an Automated Telephone Self-Management Support Intervention. J Diabetes Sci Technol. 2013 May 3;7(3):596-601. 134. Mangurian C, Shumway M, Perez-Stable E, Fuentes-Afflick E, Dilley J, Schillinger D. Primary Care Providers’ Views on Metabolic Monitoring of Outpatients Taking Antipsychotic Medications. Psychiatr Serv. 2013 Jun 1;64(6):597-9. doi: 10.1176/appi.ps.002542012. 135. Lyles CR, Wolf MS, Schillinger D, Davis TC, DeWalt D, Dahlke AR, Curtis L, Seligman HK. Food Insecurity in Relation to Changes in Hemoglobin A1c, Self-Efficacy, and Fruit/Vegetable Intake during a Diabetes Educational Intervention. Diabetes Care. 2013 Jun;36(6):1448053. Doi: 10.2337/dc12-1961. Epub 2012 Dec 28. 136. Hudson DL, Karter A, Fernandez A, Adams A, Schillinger D, Moffet H, Adler N. Differences in the Clinical Recognition of Depression in Diabetes Patients: The Diabetes Study of Northern California (DISTANCE). Am J Manag Care. 2013;19(5):344-352. 137. Laiteerapong N, Karter AJ, John PM, Schillinger D, Moffet HH, Liu JY, Adler N, Chin MH, Huang ES. Ethnic Differences in Quality of Life in Insured Older Adults with Diabetes Mellitus in an Integrated Delivery System. J Am Geriatr Soc. 2013 Jul;61(7):1103-10. doi: 10.1111/jgs.12327. Epub 2013 Jun 24. 138. Wu J, Holmes MM, DeWalt DA, Macabasco-O’Connell A, Bibbins-Domingo K, Ruo B, Baker DW, Schillinger D, Weinberger M, Broucksou KA, Erman B, Jones CD, Cene CW, Pignone M. Low Literacy is Associated with Increased Risk of Hospitalization and Death among Individuals with Heart Failure. J Gen Intern Med. 2013 Sep;28(9):1174-80. doi: 10.1007/s11606-013-2394-4. Epub 2013 Mar 12. 139. Bauer AM, Schillinger D, Parker MM, Katon W, Adler N, Adams AS, Moffet HH, Karter AJ. Health Literacy and Antidepressant Medication Adherence among Adults with Diabetes: The Diabetes Study of Northern California (DISTANCE). J Gen Intern Med. 2013 Sep;28(9):1181-7. doi: 10.1007/s11606-013- 2402-8. Epub 2013 Mar 20. 140. Bauer AM, Parker MM, Schillinger D, Katon W, Adler N, Adams AS, Moffet HH, Karter AJ. Associations between antidepressant adherence and shared decision-making, patient-provider trust, and communication among adults with diabetes: Diabetes Study of Northern California (DISTANCE). J Gen Intern Med. 2014 Apr 5. [Epub ahead of print] 141. Ratanawongsa Neda, Handley Margaret, Sarkar Urmimala, Quan Judy, Soria Catalina, Pfeifer Kelly, Schillinger D. Diabetes Health Information Technology Innovation to Improve Quality of Life for Health Plan Members in Urban Safety Net. J Ambul Care Manage. 2014 Apr-Jun;37(2):127-37. doi: 10.1097/JAC.0000000000000019. PHS 398/2590 (Rev. 06/09) Page 9 Continuation Format Page 142. Jones-Smith JC, Kartar AJ, Warton ME, Kelly M, Kersten E, Moffet HH, Adler N, Schillinger D, Laraia B. Obesity and the Food Environment: Income and Ethnicity Differences Among People with Diabetes, the Diabetes Study of Northern California (DISTANCE). Diabetes Care. 2013 Sep;36(9):2697-705. doi: 10.2337/dc12-2190. Epub 2013 May 1. 143. Lyles CR, Schillinger D. Patient-Provider Communication and Diabetes Medication Adherence: What Do We Know and Where Do We Go from Here? Diabetes Management. 2013 3(3), 185–188. 144. Lyles C, Sarkar U, Ralston JD, Adler N, Schillinger D, Moffet HH, Huang ES, Karter AJ. Patient-Provider Communication and Trust in Relation to Use of an Online Patient Portal among Diabetes Patients: The Diabetes and Aging Study. J Am Med Inform Assoc. 2013 Nov-Dec;20(6):1128-31. Doi: 10.1126/amiajnl- 1012-001567. Epub 2013 May 15. 145. Wolf MS, Seligman H, Davis TC, Fleming DA, Curtis LM, Pandit AU, Parker RM, Schillinger D, Dewalt DA. Clinic-Based vs. Outsourced Implementation of a Diabetes Health Literacy Intervention. J Gen Intern Med. 2014 Jan;29(1):59-67. 146. Pandit AU, Bailey SC, Curtis LM, Seligman HK, Davis TC, Parker RM, Schillinger D, Dewalt D, Fleming D, Mohr DC, Wolf MS. Disease-related Distress, Self-Care and Clinical Outcomes among Low-Income Patients with Diabetes. J Epidemiol Community Health. 2014 Jan 31. Doi: 10.1136/jech-2013-203063. [Epub ahead of print] 147. Jones CD, Holmes GM, DeWalt DA, Erman B, Wu J, Cene CW, Baker DW, Schillinger D, Ruo B, Bibbins-Domingo K, Macabasco-O’Connell A, Hawk V, Broucksou K, Pignone M. Comparing Self- Reported Recall and Daily Diary-Recorded Measures of Weight Monitoring Adherence: Associations with Heart Failure-Related Hospitalization. BMC Health Serv Res. 2014 Jan 31;14:12. doi: 10.1186/1471- 2261-14-12. 148. Mangurian C, Giwa A, Shumway M, Dilley J, Fuentes-Afflick E, Perez-Stable E, Schillinger D. Primary Care Providers’ Views on Metabolic Monitoring of Outpatients Taking Antipsychotic Medication. Psychtr Serv. 2013 Jun;64(6):597-9. doi: 10.1176/appi.ps.002542012. 149. Lyles C, Aulakh V, Jameson W, Schillinger D, Sarkar U. Innovation and Transformation in California’s Safety Net Healthcare Settings: An Inside Perspective. Am J Med Qual. 2013 Oct 29. [Epub ahead of print] 150. Ratanawongsa N, Schillinger D. Ethnically Diverse Patients’ Perceptions of Clinician Computer Use in a Safety Net Clinic. J Health Care Poor Underserved. 2013 Nov;24(4):1542-51. doi: 10.1353/hpu.2013.0188. 151. Sarkar U, Lyles CR, Parker MM, Allen J, Nguyen R, Moffet HH, Schillinger D, Karter AJ. Use of the Refill Function through an Online Patient Portal is Associated with Improved Adherence to Statins in an Integrated Health System. Ann Int Med. 2013 Dec 26. [Epub ahead of print] 152. Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D. Poor Knowledge of Methotrexate Associated with Older Age and Limited English Language Proficiency in a Diverse Rheumatoid Arthritis Cohort. Arthritis Res Ther. 2013;15(5):R157. 153. Brach C, Dreyer B, Schillinger D. Physicians’ Roles in Creating Health Literate Organizations: A Call to Action. In press. J Gen Int Med. 2014 Feb;29(2):273-5. doi: 10.1007/s11606-013-2619-6. 154. Rosland A, Piette J, Lyles CR, Parker MM, Moffet HH, Adler N, Schillinger D, Karter AJ. Social Support and Lifestyle vs. Medical Diabetes Self-Management in the Diabetes Study of Northern California (DISTANCE). Ann Behav Med. 2014 May 3. [Epub ahead of print] 155. Chaufan C, Karter AJ, Moffet HH, Quan J, Parker MM, Kruger J, Schillinger D, Fernandez A. Measuring Physician Spanish Competence: The Diabetes Study of Northern California (DISTANCE). In press. Med Care. 2013. 156. Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E. English Language Proficiency, Health Literacy, and Trust in Physican are Associated with Shared Decision-Making in Rheumatoid Arthritis. J Rheumatol. 2014 Jun 15. Pii:jrheum.131350. [Epub ahead of print] 157. Chaufan C, Karter AJ, Moffet HH, Quan J, Parker MM, Kruger J, Schillinger D, Fernandez A. Measuring Physician Spanish Competence: The Diabetes Study of Northern California (DISTANCE). In press. Med Care. 2013. 158. Bailey S, Schillinger D. Expanding the Universal Medication Schedule: A Patient-Centered Approach. In press. BMJ Qual Saf. 2013.

PHS 398/2590 (Rev. 06/09) Page 10 Continuation Format Page 159. Van den broucke S, Van der Zanden G, Chang P, Pelikan J, Schillinger D, Schwarz P, Sorensen K, Yardley L, Riemenschneider H. Enhancing the Effectiveness of Diabetes Self-Management Education: The Diabetes Literacy Project. In press. Horm Metab Res. 2014. 160. Rogers E, Handley M, Fine S, Davis H, Schillinger D. Development and Early Implementation of The Bigger Picture, A Youth-Targeted Public Health Literacy Campaign to Prevent Type 2 Diabetes. In press. J Health Comm. 2014. 161. Adams A, Parker M, Moffet HH, Adler N, Schillinger D, Karter AJ. Impact of a Pharmacy Benefit Change on New Use of Mail Order Pharmacy among Diabetes Patients: The Diabetes Study of Northern California (DISTANCE). In press. Heath Serv Res. 2014.

D. Research Support Current UL1 RR024131 Johnston (PI) 9/30/06 – 6/30/16 NIH Clinical and Translational Science Institute To forge a transformative, novel, and integrative academic home for Clinical and Translational Science to:1) captivate, advance, and nurture a cadre of well-trained inter-disciplinary investigators and research teams; 2) create an incubator for innovative research tools and information technologies; and 3) synergize multidisciplinary and inter-disciplinary clinical and translational research and researchers to catalyze the application of new knowledge and techniques to clinical practice at the front lines of patient care. Dr. Schillinger is on the steering committee of the community engagement initiative of CTSI, and is charged with helping to stimulate practice-based implementation and effectiveness research.

Fellowship in Health Literacy Schillinger 7/1/11 – 6/30/13 Pfizer “Health Literacy and Chronic Disease Communication in an Era of Computers in the Room: Pitfalls and Promise” This proposal seeks to understand how electronic health record systems (EHRs) use affects chronic disease health communication, explore differences in EHR use across health literacy levels, and develop a future leader with the skills to study and shape this process to meet communication needs of vulnerable populations.

Family Fund Schillinger 7/1/11 – 6/30/14 “Bridging the Digital Divide in Diabetes Among the Underserved: From Populations to Patients” To bring health IT innovations in population and patient-level DM management to the underserved, thereby enabling safety net practices and the vulnerable populations that they disproportionately care for to affirmatively respond to the challenges and opportunities presented by health reform.

Family Fund Schillinger 8/1/11 – 7/31/14 “Brave New Voices: Empowering Minority Youth to Engineer a Diabetes Prevention Social Media Campaign” To increase the health literacy and ‘health agency’ of minority youth around the diabetes epidemic, and will create multiple opportunities to bring minority youth and young adult voices and perspectives into the discourse about diabetes, enabling more effective interventions to improve health and to accelerate changes in diabetes-related policy and practice.

Seventh Framework Programme (FP7) Van den Broucke (PI) 11/1/12 – 10/31/15 “Enhancing the (cost-)effectiveness of diabetes self-management education: A comparative assessment of different educational approaches and conditions for successful implementation” (DIABETES LITERACY) The study aims to assess and compare the effectiveness and cost-effectiveness of different methods for diabetes self-management education (individual and group education, IT based education, and self-help), assess the implementation fidelity of current diabetes self-management education programs, consider the moderating role of health literacy in self-management education for diabetic patients and develop and test

PHS 398/2590 (Rev. 06/09) Page 11 Continuation Format Page literacy-appropriate diabetes education materials. It will also assess the conditions for effectiveness of self- management education programs in the way the health services are organized. Role: Co-Investigator.

P30 DK092924-01 Schmittdiel (PI) 9/1/11 – 8/31/16 NIH/NIDDK The HMO Research Network – University of California San Francisco Center for Diabetes Translational Research (CDTR) The purpose of the UCSF-HMO Research Network Center for Diabetes Training and Research (CDTR) is to create a robust network of investigators, clinicians, and health care operational leaders with expertise in diabetes translational research that will support ongoing research and foster new translational research; create Translational Research Cores in Health Disparities, Diabetes and Obesity Prevention, and Health IT that will provide content expertise to researchers and clinicians at the CDTR sites and their broader communities; mentor junior faculty interested in careers focused on T2DM prevention and care; support and fund preliminary research that will provide data for planning diabetes translational research by Early Stage Investigators; and serve as a resource for the state through a partnership between the CDTR and California Diabetes Program.

1B1CMS330882 Kohatsu (PI) 9/13/11 – 9/12/16 Centers for Medicare & Medicaid Services “Medicaid Incentives for the Prevention of Chronic Diseases (MIPCD)” To deliver financial incentives to Medicaid beneficiaries with one or more chronic diseases (e.g. diabetes) in California to promote smoking cessation through the use of the California Smoker’s Helpline services.

Susan G. Komen for the Cure Joseph (PI) 7/01/12 – 6/30/14 “Translating Cancer Genetics for the Safety Net Setting” The overall goal of the study is to elucidate the strengths and limitations of current communication practices and to develop support strategies that foster effective genetic counseling with underserved, safety net (public or county hospital/clinic) patients. Role: Co-Investigator.

1P60MD006902 NIMHD Comprehensive Bibbins-Domingo (PI) 8/27/12 – 2/28/17 Centers of Excellence “Addressing Disparities in Chronic Disease with a Teen and Young Adult Focus” To create the Center for Health And Risk in Minority youth and adults (CHARM), a new comprehensive center of excellence that will focus on chronic conditions and chronic disease risk in Latinos, African Americans and Asians across the arc from adolescence to young adulthood (age 8 to 35 years) as targeted prevention at this age group has the potential to greatly impact minority health and health disparities. Role: Co-Investigator; Outreach Core Director.

R24HS022047 Sarkar (PI) 4/1/13 – 1/31/16 AHRQ “California Safety Net Institute Innovation and Dissemination Network” The overall goal of this proposal is to harness the potential of the current partnership between UCSF and SNI to forge a self-sustaining network that will lead dissemination and implementation efforts for evidence based practices across all the public hospitals’ integrated delivery systems in California.

R33 Wallhagen (PI) 3/31/13 – 2/29/16 NIH NIDCH “Primary Care Intervention Promoting Hearing Health Care Service Access and Use” The purpose of the R21 phase is to develop, pilot test, and further refine a screening and educational program for older adults with hearing loss that is designed to promote access to and effective use of hearing health services (HHC). The purpose of the R33 phase of the proposal is to utilize a randomized controlled trial to test the comparative effectiveness within a primary care setting of three protocols for older adults ≥ 60 years of age who are not currently wearing hearing aids and who screen positive as at risk for hearing loss on subsequent access to and effective use of hearing health services. PHS 398/2590 (Rev. 06/09) Page 12 Continuation Format Page Role: Co-investigator.

R01AG045043 Sudore (PI) 9/1/13 – 5/31/18 NIH NIA “Improving Advance Care Planning by Preparing Diverse Seniors for Decision Making” This project will determine the efficacy of a novel, patient-centered, multi-media website called PREPARE. PREPEARE is focused on preparing ethnically diverse, older adults to communicate their wishes with surrogate decision makers and clinicians and to make complex medical decisions over the course of serious and chronic illness. This project will result in a practical advance care planning guide that will be easy-to-use and disseminate and result in diverse, older adults who are prepared for complex medical decision making. Role: Co-investigator.

#1019627 Seligman (PI) 11/1/13 – 9/30/14 Public Health Institute “Champion Physicians” The goal of this project is to train, develop, and support a cadre of physicians to become leaders and spokespersons in their local communities and use their sphere of influence to promote policy, systems and environmental changes to prevent weight-related chronic diseases especially amongst low-income Californians.

CDR-1306-01500 Sudore(PI) 04/01/2014-03/31/2017 Patient-Centered Outcomes Research Institute Preparing Spanish-speaking Older Adults for Advance Care Planning and Medical Decision Making The project aims are: 1) to adapt and refine PREPARE in Spanish through cognitive interviews with Spanish- speaking Latinos and stakeholders, 2) to conduct an RCT to compare the efficacy of PREPARE plus a previously-tested, easy-to-read AD (intervention) versus the AD alone (control), and 3) to disseminate PREPARE with input from patients, surrogates and stakeholders. Role: Co-Investigator

Pending: R01 Sarkar (PI) 9/1/2012 – 8/31/2017 NIDDK “Health literacy and use of an internet-based patient portal in diabetes” The long-term goal of this research is to: i) inform strategies to employ health information technology (HIT) effectively for patients with limited health literacy to reduce chronic disease disparities and ii) contribute to an expanded definition of health literacy that extends beyond verbal and written communication between the patient and health system by including ability to effectively use HIT-enabled health service access. Role: Co-investigator.

Recently Completed California Healthcare Foundation Wolf (PI) 5/21/2012 – 11/30/13 “Advancing the Universal Medication Schedule” The overall objective of this study is to expand the current Universal Medication Schedule framework to promote understanding of non-pill form, short duration, as needed, and tapered dose medication instructions. Role: Site PI.

1R18HS019209-01 Yelin (PI) 9/1/10 – 8/31/13 AHRQ “Medication Summary Guides for Vulnerable Populations with Rheumatoid Arthritis” The purpose is to evaluate patient comprehension of existing medication guides for rheumatoid arthritis; adapt content of such guides to meet the linguistic and literacy capacities of diverse patients; and test the effectiveness of different communication methods to improve decision-making.

PHS 398/2590 (Rev. 06/09) Page 13 Continuation Format Page American College of Rheumatology Yelin (PI) 7/01/07 – 6/30/09 “Disparities in Utilization and Outcomes in RA” The project takes advantage of an accruing cohort of over 500 patients with rheumatoid arthritis (RA) across 3 health systems to explore racial and socioeconomic disparities and explanatory pathways across the spectrum of RA care. Role: Co-Investigator.

San Francisco General Schillinger (PI) 4/01/07 – 3/31/10 Hospital Foundation (Hearst Family Award) “Interactive Voice Response System to Transform Diabetes Care Among Vulnerable Populations” This grant will support the implementation, evaluation and dissemination of proactive telephonic self- management support applications and related interventions for vulnerable populations with chronic disease.

Missouri Health Foundation Wolf (PI) 11/01/07 – 10/30/10 ACP Foundation “Evaluating the Missouri Health Literacy & Diabetes Communication Initiative” To implement and evaluate the effects of a patient centered diabetes guide among diabetes patients in Missouri community health centers.

UB4HP19046 Aronson (PI) 7/1/10 – 6/30/11 Health Resources and Services Administration (HRSA) Northern California Geriatric Education Center The mission of the Northern California Geriatric Education Center (NorCal GEC) is to improve education and training in geriatrics for interdisciplinary teams of health professionals and to advance the quality and availability of health care for older adults in Northern California, with special attention to those in underserved or culturally and linguistically marginalized communities.

R01 CA115861 McCormack (PI) 11/01/07 – 7/31/11 NCI/Research Triangle Institute “Development of an Instrument to Measure Health Literacy” To develop and validate a set of health literacy measures for chronic disease and cancer.

R18 HS017261 Schillinger (PI) 9/01/07 – 8/31/11 “Harnessing Health IT for Self-Management Support and Medication Activation in a Medicaid Health Plan” This project will evaluate the effects of an automated telephone diabetes self-management support intervention on quality and safety among enrollees of a California Medicaid health plan.

R18 HS017784-01 Kahn (PI) 9/01/08 – 8/31/11 AHRQ “Randomized Controlled Trial Embedded in an Electronic Health Record” The aims of this project are to determine the efficacy of PHRs by comparing HIV/AIDS patients with access to the PHR and those without access. The outcomes of interest include laboratory markers, satisfaction and use of the system and trust measures.

20091181 Wolf (PI) 8/1/2009 – 12/31/2011 NWU/CA Endowment “Development of Multilingual Prescription Drug Instructions for Pharmacy Practice” The proposed study seeks to address the problem of poorly communicated Rx instructions by targeting the most tangible and frequently-used informational source: Rx label instructions. The labels will be refined and translated into the 5 most commonly spoken languages in California; Spanish, Chinese, Vietnamese, Korean and Russian. These instructions will then be pilot tested among 200 limited English proficiency patients speaking each of the indicated languages.

R01 HL081257 Pignone (PI) 9/1/06 – 5/31/12 NIH/National Heart, Lung, and Blood Institute PHS 398/2590 (Rev. 06/09) Page 14 Continuation Format Page “Health Literacy & Self-Management in Heart Failure” Multi-site randomized trial of a heart failure disease management program for low literacy adults. Goal is to determine if disease management focused on teaching self-care behaviors is effective and whether its efficacy is greater for patients with low literacy skills. Role: Site PI.

R03HS020684-01 Handley (PI) 7/1/11 – 6/30/12 NIH “Evaluating Implementation of a Health IT Intervention for Vulnerable Patients with Diabetes” The purpose of this study is to examine the fidelity of the intervention’s implementation and examine adaptations made to increase adoption. This information can inform efforts underway in national health reform, to scale up health IT interventions to off-set growing chronic disease care costs. Role: Co- Investigator.

McKesson Foundation Schillinger (PI) 7/1/10 – 6/30/12 “Patient response to medication intensification counseling in a diabetes telemedicine intervention” To harness pharmacy claims data to determine the extent to which a Medicaid managed care diabetes population could benefit from adherence counseling or medication intensification for cardiovascular risk reduction; assess reported willingness of participants to intensify diabetes therapies and explore factors associated with this preference; and measure the relationship between SMARTSteps participants’ willingness to intensify cardiovascular risk reduction therapies and primary care providers' decisions to intensify medication regimens.

California Health Care Safety Net Institute Sarkar (PI) 11/1/11 – 10/31/12 (SNI) “Building an Innovations Exchange for California’s Safety-Net Health System” The project scope is to 1) conduct a needs assessment and landscape assessment, focusing on ambulatory health care delivery, health information technology, patient-centered medical home transformation, and transitions in care: and 2) investigate successful innovation centers and bring their strategies and approaches to SNI with recommendations for convening a successful innovations exchange. Role: Co- Principal Investigator.

AT&T Foundation Schillinger 9/1/11 – 8/31/12 “CVP-Youth Speaks Health Diabetes Prevention Campaign” To support San Francisco General Hospital and Trauma Center’s Center for Vulnerable Populations in collaborating with a community program called Youth Speaks to develop a minority youth-targeted diabetes prevention campaign using youth-generated “spoken word” messages around key diabetes prevention. Role: Principal Investigator.

R34 DK 093992-01 Powe (PI) 9/30/11 – 8/31/12 “Health IT Enhanced for CKD in Safety-Net Primary Care” We propose to evaluate an incrementally intensive set of interventions (a registry, information technology and automated telephonic patient management) to enhance awareness, improve knowledge, and foster better communication, possibly leading to better clinical outcomes for patients with chronic kidney disease cared for in a safety net clinics. Role: Co-Investigator.

08-85655 Schillinger (PI) 3/29/09 – 6/30/13 CDC/CA Dept of Public Health “California Diabetes Prevention and Control Program” The goal is to work to prevent, detect, and intervene among persons at risk for diabetes mellitus and its complications to reduce the adverse personal and public impact of diabetes on California's diverse communities.

PHS 398/2590 (Rev. 06/09) Page 15 Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Director, Special Studies, AIDS Office, San Schwarcz, Sandra K. Francisco Department of Public Health eRA COMMONS USER NAME (credential, e.g., agency login) Adjunct Assistant Professor. Epidemiology and n/a Biostatistics, University of California, San Francisco

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Santa Cruz, BA 06/79 Biology Michigan State University, E. Lansing MD 06/84 Medicine University of California, Berkeley MPH 05/86 Epidemiology Intern, Pediatrics, Kaiser Foundation Hospital, 07/86 Pediatrics San Francisco Resident, Preventive Medicine, California 06/87 General preventive Department of Health Services, Berkeley, CA medicine and public health Epidemic Intelligence Service Officer, Centers for 06/89 Epidemiology Disease Control, Division of Sexually Transmitted Diseases, Atlanta, GA Resident, Children’s Hospital Oakland, Oakland, 06/90 Pediatrics CA

A. Personal Statement

The goals of the proposed study are twofold: to 1) assess how the level of immunosuppression at the time of ART initiation, cancer treatments, and HIV viral suppression affect the risk of a second primary cancer among people with HIV/AIDS, and 2) determine the impact of HIV infection, type of first primary cancer, and cancer treatment on the time to a second primary cancer among survivors of first primary cancers. This study is a significant extension on earlier work that computer-matched the San Francisco AIDS case and the California cancer registries to measure the effect of highly active ART on the risk of developing AIDS-defining and non- AIDS–defining cancers from 1990 through 2000. This proposed study will expand our analysis another 10 years, through 2010, and incorporate new data elements (ART regimen and HIV viral load) and statistical methodologies. The San Francisco AIDS case registry is unique because it contains prospectively collected information on use of ART, CD4+ cell counts, and HIV viral load and because of the high rates of Kaposi sarcoma among San Francisco AIDS cases. In addition to our previous study of ART and cancers, Professor Hessol and I have been colleagues for well over 20 years and collaborated on a study in which we computer- matched data from a cohort study of HIV-infected women with the SF AIDS case registry to measure the validity of self-reported occurrence of AIDS-indicator conditions. Our productive work together on prior studies and our long-standing professional relationship provide evidence that this too will be a successful research collaboration. In addition to offering my general knowledge of this topic area, I will provide clinical expertise on the information from the HIV/AIDS surveillance database regarding the use and interpretation of CD4+ and HIV RNA test results and HIV treatment.

B. Positions and Honors

Positions and Employment 09/81–03/84 Graduate Assistant, Michigan State University Department of Psychiatry and the Medical Humanities Program, E. Lansing 07/85–06/86 Physician, Solano County Department of Public Health, CA 08/86–06/87 Physician, San Francisco Department of Public Health 04/88–06/89 Adjunct Instructor, Emory University, Department of Community Medicine, Atlanta, GA 07/89–12/89 Medical Epidemiologist, Centers for Disease Control, New York City Department of Health, Bureau of Sexually Transmitted Disease Control 12/90–06/91 Research Physician, Children’s Hospital, Oakland, CA 12/90–02/93 Medical Epidemiologist, Division of Sexually Transmitted Disease Control, San Francisco Department of Public Health 02/93–04/96 Medical Epidemiologist, AIDS Office, San Francisco Department of Public Health 04/96–10/06 Director, HIV/AIDS Statistics and Epidemiology Section, San Francisco Department of Public Health 07/99–present Adjunct Assistant Professor, University of California, San Francisco, Department of Epidemiology and Biostatistics 10/05–present Director, Special Studies HIV/AIDS Statistics and Epidemiology Section, San Francisco Department of Public Health Honors University of California Highest Honors in Biology Stevenson College Honors Public Health Trainee tuition award Federal public advisory committees 2007 External peer review of CDC Division of HIV/AIDS Prevention Surveillance, Research, and HIV Programs, surveillance panel. 2005 Determination of methods of classifying HIV/AIDS risk, workgroup for Centers for Disease Control and Prevention. 2003–2005 Ethical uses of public health data, workgroup for Centers for Disease Control and Prevention.

C. Selected peer-reviewed publications (Selected from 68 peer-reviewed publications)

1. Muthulingam D, Chin J, Hsu L, Scheer S, Schwarcz S. Disparities in Engagement in Care and Viral Suppression among Persons with HIV. (2013) J Acquir Immuno Defic Syndr (published ahead of print Feb 2013) PMID: 23392459 2. Schwarcz L, Chen MJ, Vittinghoff E,Hsu L, Schwarcz S. Declining Incidence of AIDS-defining opportunistic illnesses: results from 16 Years of population-based AIDS surveillance. AIDS 2012 [October 17 published ahead of print]. PMID: 23079812 3. Hessol NA, Schwarcz S, Ameli N, Oliver G, Greenblatt RM. (2001). Accuracy of self-reports of acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related conditions in women. Am J Epidemiol, 153:1128-33. PMID 17075386 4. Schwarcz S, Weinstock H, Louie B, Kellogg T, Douglas J, LaLota M, Dickinson G, Torina L, Wendell D, Paul S, Goza G, Ruiz J, Boyett B, McCormich L, Bennett D. (2007). Characteristics of persons with recently acquired HIV infection from 10 cities in the United States: application of the Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS). J Acquir Immuno Defic Syndr;44;112-5.PMID 7075386 5. Hessol NA, Pipkin S, Schwarcz S, Cress R, Bacchetti P, Scheer S. (2007 ). The Impact of HAART on Non- AIDS Defining Cancers Among Adults with AIDS. Am J Epidemiol; 15;165:1143-53. PMID 11390333 6. Schwarcz S, Spindler H, Scheer S, Valleroy L, Lansky A. (2007). Assessing Representativeness of Sampling Methods for Reaching Men Who Have Sex with Men: A Direct Comparison of Results Obtained from Convenience and Probability Samples. AIDS Behav;11:596-602. PMID 17436073 7. Schwarcz S, Scheer S, McFarland W, Katz M, Valleroy L, Chen S, Catania, J. (2007). Prevalence of HIV infection and predictors of high transmission risk behaviors: results from a probability sample of men who have sex with men. Am J Public Health; 97:1067-75. PMID 17463384 8. Scheer S, Kellogg T, Klausner JD, Schwarcz S, Colfax G, Bernstein K, Louie B, Dilley JW, Hecht J, Truong HM, Katz MH, McFarland W. (2008). HIV is hyperendemic among men who have sex with men in San Francisco: 10-year trends in HIV incidence, HIV prevalence, sexually transmitted infections, and sexual risk behavior. Sex Transm Infect, 84:493-8. PMID 19028954 9. Schwarcz S, Hsu, L, Vittinghoff, E, Vu A, Bamberger J, Katz, M. (2009). Impact of housing on the survival of persons with AIDS. BMC Public Health; 9:220. PMCID: PMC2728715 10. Pipkin S, Scheer S, Okeigwe I, Schwarcz S, Harris DH, Hessol NA. (2011). The effect of HAART and calendar period on Kaposi’s sarcoma and non-Hodgkin lymphoma: results of a match between an AIDS and cancer registry. AIDS;25:463-71. PMCID: PMC3089985 11. Hsu LC, Chen M, Kali J, Pipkin S, Scheer S, Schwarcz S. (2011). Assessing receipt of medical care and disparity among persons with HIV/AIDS in San Francisco, 2006-2007. AIDS Care 23:383-92. PMID: 21347902 12. Schwarcz S, Richards TA, Frank H, Wenzel C, Hsu LC, Chi-Sheng JC, Murphy J, Murphy J, Dilley J. (2011). Identifying barriers to HIV testing: personal and contextual factors associated with late HIV testing. AIDS Care; 23(7):892-900. PMID: 21424942 13. Dilley JW, Scheer S, Schwarcz S, Murphy J, Joseph C, Vittinghoff E. (2011). Efficacy of Personalized Cognitive Counseling in Men of Color who Have Sex: with Men: secondary data analysis from a controlled intervention trial. AIDS and Behavior 15:970-5. PMCID: PMC3111548 14. Schwarcz L, Chen MJ, Vittinghoff E, Hsu L, Schwarcz S. (2013). Declining incidence of AIDS-defining opportunistic illnesses: results from 16 years of population-based AIDS surveillance. AIDS. Feb 20; 27(4):597-605. PMID: 23079812 15. Hsu LC, Troung HH, Vittinghoff E, Zhi Q, Scheer S, Schwarcz S. (2013). Trends in Early Initiation of Antiretroviral Therapy and Characteristics of Persons with HIV Initiating Therapy in San Francisco, 2007- 2011. J Infect Dis. Dec 4. PMID: 24218501

D. Research Support

Ongoing Research Support

U2GPS001814 Rutherford (PI) 01/01/2009-09/31/2014 University of California, San Francisco (Sub award) Centers for Disease Control and Prevention (Sub award) UCSF's University Technical Assistance Program which supports CDC's Global AIDS Program in surveillance and monitoring & evaluation activities. Role: Co-Investigator

PS13-1302 (Hsu, PI) 01/01/201312/31/2017 CDC HIV/AIDS Core Surveillance and Incidence Component A (Case surveillance) and Component B (incidence) The main goals of the HIV/AIDS Core Surveillance and Incidence program are to use our successful methods of HIV/AIDS case reporting to maintain a highly complete and accurate HIV/AIDS case registry. This information is widely disseminated to the community and is used to inform prevention efforts. Role: Co-Investigator

Completed Research Support

R01-MH73425 Dilley (PI) 09/01/2005-08/31/2010 NIMH Reducing HIV transmission risk behavior: a trial of a two-session risk-reduction intervention with HIV-positive men who have sex with men

The goal of this study is to test the efficacy of personalized cognitive counseling in reducing episodes of unprotected anal intercourse among HIV-infected men who have sex with men Role: Co-Investigator

1U62PS001000 Hsu (PI) 01/01/2008–12/31/2012 CDC HIV/AIDS Core Surveillance and Incidence

The main goals of the HIV/AIDS Core Surveillance and Incidence program are to use our successful methods of HIV/AIDS case reporting to maintain a highly complete and accurate HIV/AIDS case registry. In addition, we have integrated core surveillance activities with HIV incidence goals to collect a complete testing history and thorough treatment information from newly diagnosed HIV cases. Those data also allow us to collect a specimen for STARHS testing to develop an incidence estimate for San Francisco and identify the populations at greatest risk for new infections. This information is widely disseminated to the community and is used to inform prevention efforts. Role: Co-Investigator

Jaime Sepulveda, M.D., M.P.H., M.Sc., Dr.Sc. Executive Director, Global Health Sciences University of California, San Francisco (UCSF)

Dr. Jaime Sepulveda is the Executive Director of UCSF Global Health Sciences, and Professor of Epidemiology, at the University of California, San Francisco. A member of the Chancellor’s Executive Cabinet, he leads a team of over 260 faculty and staff engaged in translating UCSF’s scientific leadership into programs that positively impact health and reduce inequities globally. Sepulveda oversees several education and training programs, including the Masters of Science in Global Health Sciences degree program, the first such program in the nation.

Sepulveda’s areas of research expertise include HIV/AIDS, vaccines, health surveillance and metrics, neglected infectious diseases, maternal & neonatal health, health policy, and global health initiatives.

Sepulveda is the Principal Investigator for the FIRST (Fighting Infections through Research, Science & Technology) program, which tackles neglected infectious diseases in Mesoamerica. He is the co-director of the new UCSF Preterm Birth initiative, and has recently served as a guest editor for global health supplements in Health Affairs and Science.

From 2007 to 2011, Dr. Sepulveda was a member of the Foundation Leadership Team at the Bill & Melinda Gates Foundation. He served at the BMGF in various roles: as Director of Integrated Health Solutions, Director of Special Initiatives and Senior Fellow in the Global Health Program. He also played a central role in shaping the foundation’s overall global health strategy as part of its executive team. Dr. Sepulveda worked closely with key foundation partners—including the GAVI Alliance, where he chaired the Executive Committee—to increase access to vaccines and other effective health solutions in developing countries. As Vice-Chair of the GAVI Board, he contributed to improve the governance and management of the organization.

Sepulveda worked for more than 20 years in a variety of senior health posts in the Mexican government. After graduating from Harvard University where he obtained his Doctorate, he became Mexico’s Director-General of Epidemiology. At age 36, he was appointed Vice-Minister of Health. From 2003 to 2006, he served as Director of the National Institutes of Health of Mexico. He was for almost a decade Director-General of Mexico’s National Institute of Public Health and Dean of the National School of Public Health. In addition to his research credentials, Sepulveda is an experienced implementer of effective health programs. Sepulveda designed Mexico’s Universal Vaccination Program, which eliminated polio, measles, and diphtheria by achieving universal childhood immunization coverage. He also modernized the national health surveillance system, created the National Health Surveys System and founded Mexico’s National AIDS Council.

Sepulveda holds a medical degree from National Autonomous University of Mexico and two Masters and a Doctorate degree from Harvard University. In 1997, he was awarded the Harvard’s Alumni Award of Merit. Dr. Sepulveda was elected to and served in the Harvard Board of Overseers (2002-2008). He is a member of the Institute of Medicine of the U.S. National Academy of Sciences. Principal Investigator/Program Director (Last, First, Middle):

NAME POSITION TITLE James Seward, M.D. Clinical Professor of Medicine eRA COMMONS USER NAME Chair, Residency Advisory Committee

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of California, San Francisco 1981-1982 Occupational Medicine Fellow University of California, San Francisco 1980-1982 Robert Wood Johnson Clinical Scholar University of California, San Francisco 1977-1980 Internal Medicine Resident University of California, San Francisco M.D. 1977 Medicine University of California, Berkeley M.P.P. 1977 Public Policy Tulane University M.M.M 2003 Medical Management

A. Positions and Honors

Positions and Employment: 1980-1999 Attending Physician, San Francisco General Hospital Emergency Room (part time) 1982-1994 Director, Occupational Health Program, University of California at Berkeley 1991-1996 Director, Preventive Medicine Residency Program, School of Public Health, University of California, Berkeley 1994-Present Director, Health Services Department, Lawrence Livermore National Laboratory, Livermore, California 1995-Present Co-Director of Preventive Medicine Residency Program, School of Public Health, University of California at Berkeley, Berkeley, California

Certifications: 1978 Licensed Physician, State of California (G-038062) 1980 Diplomate, American Board of Internal Medicine 1982 Diplomate, American Board of Preventive (Occupational) Medicine 1996 Diplomate, American Board of Medical Management Current BNDD Certificate

Academic Appointments: Clinical Professor of Medicine, UCSF Clinical Professor of Public Health, UC Berkeley

Other Experience and Professional Memberships: Medical Director, Lawrence Livermore National Laboratory Chair, Occupational Medicine Residency Advisory Committee, UCSF Board Member, American College of Occupational and Environmental Medicine Past President and Chairman, Western Occupational and Environmental Medical Association Past Occupational Medicine Regent, American College of Preventive Medicine

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Past President, California Academy of Preventive Medicine Editorial Board Member, University of California at Berkeley Wellness Letter

B. Selected peer-reviewed publications Arjomandi M, Seward J, Balmes J et al. Low Prevalence of Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility. JOEM 52(6) 647-652 ( 2010)

Seward J and Larsen R: “Occupational Stress” in LaDou J (4th ed.) Current Occupational and Environmental Medicine. McGraw Hill 2007

Whorton D, Moore D, Seward J, Noonan K, and Mendelsohn M: Cancer Incidence Rates Among Lawrence Livermore National Laboratory Employees 1974-1997. Am J Ind Med 45:24-33 (2004)

Seward J: “Occupational Stress” in LaDou J (ed.) Current Occupational and Environmental Medicine. McGraw Hill 2004

Seward J: Shiftwork: Scheduling Impacts on Safety and Health in Lack R: Safety, Health and Asset Protection, Lewis Publishers/CRC Press 2002

Rutherford MW and Seward JP: Radiation Injuries and Illnesses in Pediatric Emergency Medicine. Clin Ped Emerg Med 2001; 2:141-54

Breitenstein B and Seward J: “Radiation Injuries” in Wald P and Stave G, Physical Hazards of the Workplace. Wiley and Sons, New York. 2001

Seward J: Medical Surveillance of Allergy in Laboratory Animal Handlers. ILAR Journal, National Academy of Science 42(1) 47-54. 2001 Publications (Cont.)

Seward J. “Occupational Allergy to Animals” in Occupational Medicine State of the Art Reviews 14:2:285-303. Hanley Belfus, Philadelpia, 1999.

Novotny T, Seward J, Sun R, et al.: The Sausage Factory Tour of the Legislative Process. American Journal of Public Health, 89:5:771-3 (May, 1999)

Seward J: Occupational Stress in Occupational Medicine; LaDou, J. Ed. Appleton and Lange, 1997.

Seward J. Occupational Lead Exposure and Management” Western Journal of Medicine 165:222-3, 1996.

Levin, Holly, and Seward. “Bladder Cancer in a Pharmacist.” Journal of National Cancer Institute 85; 13; 1089-1090, July 7, 1993.

Seward J. “Progress in Occupational Stress – Organizational Interventions.” Western Journal of Medicine 156:4, April 1992.

Olsen K, Pond S, Seward J. “Amanita Type Mushroom Poisoning” Western Journal of Medicine 137(4)282-289 1982.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Invited Presentations

Human Health Implications from Radiation after the Fukushima Reactor Disaster: University of Tokyo and Woods Hole Oceanographic Institute Symposium. Tokyo, Japan. Nov 12, 2012

Radiation and Human Health: Recent International and Domestic Issues. UCSF Occupational And Environmental Update. San Francisco, Nov 3, 2012

Lessons for Japan from the Chernobyl Cancer Experience. UCSF Symposium on the Great East Japan Earthquake and Disasters. March 2012 San Francisco

How Do We Measure Success in Occupational Medicine? US Dept. of Energy Occupational Medicine Group. Brookhaven National Lab. Oct 2010.

Occupational Lead Exposure Management, American College of Occupational and Environmental Medicine Webinar, Dec. 2009

Allergy in Animal Handlers; UCSF Advances in Occupational Medicine, March 2010 Update in Lead Toxicity; American College of Occupational and Environmental Medicine. San Diego April 2009.

Health and Productivity. California Society of Industrial Medicine and Surgery. Berkeley, California. June 2008

Health and Productivity at the Workplace: Practical and Methodological issues. US Department of Energy Occupational Medicine Group, Albuquerque April 2007

Pandemic Influenza Planning at the Worksite. American Association for the Advancement of Science (AAAS) San Francisco, February, 2007.

Internal Radiation Contamination: University of California, Davis Occupational and Environmental Updates Conference, June 2005

Management of Internal Radiation Contamination Injuries; Western Occupational Health Conference, Lake Las Vegas, September 2004

Occupational Health for Animal Care Workers, Advances in Occupational Medicine, University of California San Francisco, April 2003

Occupational Health Problems of Animal Handlers; Continuing Education in Occupational Medicine; University of California, San Francisco; February 2000

Risk Assessment and Occupational Allergy to Animals; California Biomedical Research Association; Stanford University; June 1999.

Organizational Theory for Occupational Medicine Physicians; Continuing Education Programs in Occupational Medicine; University of California, San Francisco; April 1999.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Medical Surveillance and Worker Health; Occupational Health Forum, Lawrence Livermore Laboratory, 1995.

Stress as an Occupational Risk; Western Occupational Health Conference, Monterrey, 1991

Occupational Stress; Occupational Medicine Grand Rounds, University of California, San Francisco (SFGH); 1990.

Clinical Approach to Occupational Stress; American Academy of Occupational Medicine; 1987.

Occupational Stress: Workers at High Risk; Work and Mental Health Conference, Langley Porter Psychiatric Institute, UCSF. April 1986.

Medical Screening for Biomedical Personnel; National Institutes of Health Eighth Annual Research Safety Symposium; January 1985.

Health Effects of Alternative Work Schedules; American Occupational Health Conference; Los Angeles; May 1984.

Allergy in Animal Handlers; University of California Occupational Medicine Grand Rounds; San Francisco; September 1983.

Occupational Injuries and Job Autonomy; R. W. Johnson Foundation Clinical Scholars Meeting; November 1982.

C. Research Support

Ongoing Research Support: None

Completed Research Support: None

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page PI:

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Caroline Helene Shiboski Professor eRA COMMONS USER NAME (credential, e.g., agency login) shiboski EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Lycee Rabelais, Versailles Academy, France Baccalaureat 1978 Biology, Math, Physics Universite R. Descartes, Paris V, France D.D.S 1984 General Dentistry University of California San Francisco Certificate 1991 Advanced General Dentistry University of California, Berkeley M.P.H 1992 Epidemiology University of California San Francisco Certificate 1993 Dental Public Health University of California San Francisco Certificate 1994 Dental Clinical Epidemiology University of California, Berkeley Ph.D 1997 Epidemiology University of California San Francisco Certificate 1998 Oral Medicine University of California San Francisco, CORO Diploma 2006 Leadership training Drexel University, Executive Leadership in Diploma 2013 Leadership training Academic Medicine (ELAM)

A. PERSONAL STATEMENT As an Oral Medicine specialist and Epidemiologist my research experience focuses on the epidemiology of oral cancer (through the use of registry data), and on the oral complications of various forms of immune dysfunction (both immunosuppressive conditions, and autoimmunity). On the latter topic I have extensive experience designing and implementing clinical studies in the US and internationally. I implemented a collaborative study, funded through the AIDS Fogarty Program, exploring oral candidiasis as a surrogate marker of HIV disease progression among women in Zimbabwe. As the principal investigator (PI) of the Oral HIV/AIDS Research Alliance Epidemiology/Clinical Sciences Unit (a multicenter grant that is part of the AIDS Clinical Trial Group Network or ACTG), I have led the development and implementation of number of study protocols pertaining to the oral complications of HIV, notably HPV-related oral infection, in the US, Haiti, Africa, and India. I am also the lead Epidemiologist and the PI (with co-PI Lindsey Criswell) of the Sjögren’s Syndrome International Collaborative Clinical Alliance (SICCA) biorepository, a project aimed at disseminating data and biospecimens to investigators worldwide for pathogenesis, epidemiologic, and genetic studies pertaining to this disease. As lead epidemiologist I played a critical role in the design of the SICCA registry (a 10-year NIH contract that preceded the current contract funding the SICCA biorepository, and for which I served as PI for the last 3 years of the contract), development of data collection instruments, and development of classification criteria for Sjögren’s Syndrome that led to these criteria, which were approved by the American College of Rheumatology in November 2011. My experience in the field of global health also pertains to teaching: 1) I developed and taught the Oral Medicine curriculum of the Department of Dentistry at the University of Zimbabwe College of Health Sciences from 1999 to 2005; and 2) for the past 7 years, I have been part of a team teaching an annual 2-week research methods course for Francophone African physicians in the Epidemiology and Public Health Unit at the Pasteur Institute in Paris. My experience in global health research and teaching is very relevant to, and makes me qualified to serve on the campus-wide working group to help determine the focus and direction of the PhD program in Global Health.

B. POSITIONS 1984-1985 Research Assistant, New Product Development, IMS America Ltd. Ambler, PA 1985-1986 Clinical Instructor, Louis Mourier Hospital Dental Clinic, Colombes, France 1985-1986 General Dentist, St. Anne Hospital Oral Surgery Clinic and private dental practice, Paris, France 1986 Research Assistant, Oral Health Research Center, Fairleigh Dickinson Univer., Hackensack, NJ PI: 1987 Dental Technician, Unique Dental Studio, Inc., Oakland, CA 1988-1989 Dental Health Instructor and Consultant, Alameda County Dental Health Bureau, Oakland, CA 1989-1994 Postgraduate Dentist University of California San Francisco (UCSF), CA 1994-2003 Assistant Clinical Professor, Dept of Stomatology, UCSF, CA 2001-present Director, Oral Medicine Clinical Center, UCSF, CA 2003-2004 Associate Clinical Professor, Dept Orofacial Sciences, UCSF, CA 2004-2009 Associate Professor, Dept Orofacial Sciences, UCSF, CA 2008-present Director, Oral Medicine Post-Graduate Residency Program, Dept Orofacial Sciences, UCSF, CA 2009-present Professor, Dept Orofacial Sciences, UCSF, CA 2010-2011 Interim Co-Director, PhD Program in Oral and Cranio-Facial Science, School of Dentistry, UCSF, CA

HONORS & AWARDS 1984 Received High Honor for doctoral thesis titled "La prevention bucco-dentaire au Danemark" 1987 "Michele Bardet-Viatte Award " for best publication on Dental Health Promotion in Departement des Yvelines, France 1994 Dentist Scientist Award, Department of Stomatology, University of California, San Francisco, CA 2001 K23 award, Department of Stomatology, University of California San Francisco, CA 2001 Diplomate of the American Board of Oral Medicine 2001 Dean’s Creativity fund Award, UCSF 2003 Academic Senate New Investigator Award, UCSF 2004 Teacher of the Year Award, Department of Stomatology, UCSF 2011 Excellence in Research Award, John Greene Society, UCSF 2012 Faculty Award for Global Oral Health, UCSF 2012-2013 Fellow of the Executive Leadership in Academic Medicine (ELAM) program for 2012-2013, Drexel University

C. SELECTED PUBLICATIONS (limited to 15)

1. Shiboski CH, Hilton JF, Neuhaus JM, Canchola A, Greenspan D, and the UCSF Oral AIDS Center Epidemiology Collaborative Group. HIV-related oral manifestations and gender: A longitudinal analysis. The Archives of Internal Medicine 1996; 156:2249-2254 PMID: 8885825 2. Shiboski CH, Neuhaus JM, Greenspan D, Greenspan JS. Effect of Receptive Oral Sex and Smoking on the Incidence of hairy leukoplakia in HIV-positive gay men. J Acquir Immune Defic Syndro 1999; 21:236-42. PMID: 10421248 3. Shiboski CH, Palacio H, Neuhaus JM, Greenblatt RM. Dental care access and utilization among HIV-infected women. Am J Public Health 1999; 89:834-839. PMID: 10358671 4. Shiboski CH, Schmidt BL, Jordan RCK. Tongue and tonsil carcinoma: Increasing trends in US population ages 20-44 years. Cancer 2005; 103(9):1843-9. PMID: 15772957 5. Shiboski CH, Schmidt BL, Jordan RCK. Racial disparity in stage at diagnosis and survival among adults with oral cancer in the U.S. Comm Dent Oral Epidemiol 2007; 35(3):233-40. PMID: 17518970 6. Chidzonga MM, Mwale M, Malvin K, Martin J, Greenspan JG, Shiboski CH*. Oral candidiasis as marker of HIV disease progression among Zimbabwean women. JAIDS 2008; 47:579-584. PMID: 18176326 7. Lefrère JJ, Shiboski CH, Fontanet A, Murphy EL. Teaching transfusion medicine research in the francophone world. Transfus Clin Biol 2009;16(5-6):427-30. 8. Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski CH. Human Herpesvirus Replication and Abnormal CD8+ T Cell Activation and Low CD4+ T Cell Counts in Antiretroviral-Suppressed HIV-Infected Patients. PLoS ONE 2009;4(4):e5277. PMID: 19381272 9. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhaao J, et al. A Simplified Quantitative Method for Assessing Keratoconjunctivitis Sicca from the Sjögren’s Syndrome International Registry. Am J Ophthalmol 2010; 149(3):405-15. PMID: 20035924 10. Dollard SC, Butler LM, Graves Jones AM, Mermin JH, Chidzonga MM, Chipato T, Shiboski CH, Brander, Mosam A, Kiepiela P, Hladik W, Martin JN. Substantial Regional Differences in Human Herpesvirus 8 Seroprevalence in Sub-Saharan Africa: Insights on the Origin of the “KS Belt”. Int J Cancer 2010; Nov 15;127(10):2395-401. PMID: 20143397 PI: 11. Shiboski CH, Hodgson T, Challacombe S, Overview and Research Agenda Arising from the 6th World Workshop on Oral Health and Disease in AIDS. Adv Dent Res 2011; 23(1):7-9. PMID: 21441472 12. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H,, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, MacNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J and Daniels T. American College of Rheumatology Classification Criteria for Sjögren’s Syndrome: A data-driven, expert consensus approach in the SICCA Cohort. Arthritis, Care & Res 2012; 64(4):475-87. Note: 1st and 2nd authors contributed equally to this work 13. Swindells S, Komarow L, Tripathy S, Cain KP, MacGregor RR, Achkar JM, Gupta A, Veloso VG, Asmelash A, Omoz-Oarhe AE, Gengiah S, Lalloo U, Allen R, Shiboski C, Andersen J, Qasba SS, Katzenstein DK; AIDS Clinical Trials Group 5253 Study Team. Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253. Int J Tuberc Lung Dis. 2013 Apr;17(4):532-9. doi: 10.5588/ijtld.12.0737. PMID: 23485388 14. Shiboski CH, Shiboski SC. Smoking is an independent risk factor for the development of oral candidiasis (OC) in HIV-1 infected persons. J Evid Based Dent Pract. 2013 Dec;13(4):180-2. PMID: 24237746 15. Shiboski CH, Chen H, Ghannoum M, Komarow L, Evans S, Mukherjee P, Isham N, Katzenstein D, Asmelash A, Omozoarhe AE, Gengiah S, Allen R, Tripathy S, Swindells S, and the AIDS Clinical Trials Group Network and the Oral HIV/AIDS Research Alliance. Role of Oral Candidiasis in Tuberculosis and HIV co-Infection: AIDS Clinical Trial Group Protocol A5253. Int J Tuberc Lung Dis 2014 (in press)

D. Research Support. Ongoing Research Support HHSN26S201300057C (PI: CH Shiboski; co-PI: L Criswell) 09/30/13-09/29/18 NIH/NIDCR International Research Registry Network for Sjogren's Syndrome (SICCA) The major goal of this contract is to disseminate data and biospecimens collected as part of the International Research Registry Network for Sjören's Syndrome to the scientific community to conduct epidemiologic and genetic studies on Sögren's Syndrome. Role: PI

U01 AI 68636 (PI Kuritzkes, CA), 06/29/06-12/31/14 NIH/NIAID/NIDCR Leadership for HIV/AIDS Clinical Trials Network Social and Scientific systems Title of site-specific project: Oral HIV/AIDS Research Alliance

The goal of the Oral HIV/AIDS Research Alliance (OHARA), that comprises 3 centers (UCSF/Clinical Science Unit, UNC/Virology Unit, and Case Western/Medical Mycology Unit), is to develop and implement an oral HIV/AIDS research agenda within the ACTG infrastructure. OHARA will provide the capacity to investigate the oral complications associated with HIV/AIDS and to address such overarching questions as the effects of potent antiretrovirals on the development of opportunistic infections (OIs) and the natural history of oral OIs, variation and resistance in the context of immune suppression. correlates. Role on project: PI of the UCSF site (Epidemiology Unit) and Chair of the Alliance

U01 HD052102 (Seage) 9/10/11 - 7/31/14 Pediatric HIV/AIDS Cohort Studies (Harvard University subcontract) NIH/NICHD/NIDCR Oral health among participants in the PHACS Adolescent Master Protocol (AMP)

This study will examine and compare the oral health and microbiome of perinatally HIV infected and HIV- exposed uninfected children and adolescents of PHACS. Drs. Moscicki and Shiboski are co-PIs of this subcontract. Role: Co-PI BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Steward, Wayne Thomas Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) wsteward EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Columbia University, New York, NY BA 1997 Psychology Yale University, New Haven, CT PhD 2002 Psychology (social) University of California, Berkeley, CA MPH 2003 Epidemiology University of California, San Francisco, CA 2002-2007 HIV prevention research (postdoctoral training)

A. Personal Statement UCSF Global Health Sciences (GHS) provides graduate level training in biomedical, public health, and social sciences that relates to monitoring, improving, and evaluating health and health systems in underprivileged portions of the world. I am responsible for co-teaching a fall term course on qualitative and quantitative research methodologies, including ethnographic observation, key informant interviewing, and survey development and administration. I also serve as academic advisor to students in the GHS masters’ degree program, and mentor students who seek research experience through projects related to my expertise. My current research portfolio includes both international and domestic projects of relevance to global health. Projects in China and India focus on assessing stigma and its impact on HIV-infected and affected populations. A project in South Africa is examining the effectiveness of two intervention models for improving engagement in HIV care and services. And my research in US domestic settings focuses on the development of more integrated and coordinated models of care, including patient-centered medical homes, to improve services for HIV-infected patients from vulnerable populations.

B. Positions and Honors.

Positions and Employment 2001 Lecturer, Southern Connecticut State University 2002-2007 Postdoctoral Scholar, Department of Medicine, University of California San Francisco (UCSF) 2007 Research Specialist, Department of Medicine, UCSF 2007-2013 Assistant Professor, Department of Medicine, UCSF 2009- Faculty Member, Global Health Sciences MS Degree Program, UCSF 2013- Associate Professor, Department of Medicine, UCSF

Honors Columbia University Graduation Honors: magna cum laude Yale University Fellowship Yale University Dissertation Fellowship NIMH Postdoctoral Trainee, UCSF Center for AIDS Prevention Studies

C. Selected peer-reviewed publications (Selected from a total of 40 peer reviewed publications)

Most Relevant to the Current Application (in chronological order)

1. Neilands TB, Steward WT, Choi K. Measuring homosexuality stigma in China: The China MSM Stigma Scale. Archives of Sexual Behavior.2008;37:838-844. 2. Wolfe WR, Weiser SD, Leiter K, Steward WT, Percy-de Korte F, Phaladze N, Iacopino V, Heisler M. Impact of universal access to antiretroviral therapy on HIV stigma in Botswana. American Journal of Public Health. 2008;98:1865-1871. 3. Choi K, Hudes ES, Steward WT. Social discrimination, concurrent sexual partnerships, and HIV risk among men who have sex with men in Shanghai, China. AIDS and Behavior. 2008;12(Suppl. 4):S71-S77. 4. Steward WT, Herek GM, Ramkrishna J, Bharat S, Chandy S, Wrubel J, Ekstrand ML. HIV Related Stigma: Adapting a Theoretical Framework for Use in India. Social Science and Medicine. 2008;67:1225-1235. PMCID: PMC2603621. 5. Steward WT, Chandy S, Singh G, Panicker ST, Osmand TA, Heylen E, Ekstrand ML. Depression is not an inevitable outcome of disclosure avoidance: HIV stigma and mental health in a cohort of HIV infected individuals from Southern India. Psychology, Health & Medicine. 2011;16:74-85. PMC3075869. 6. Steward WT, Bharat S, Ramakrishna J, Heylen E, Ekstrand ML. Stigma is associated with delays in seeking care among HIV-infected people in India. Journal of the International Association of Physicians in AIDS Care. 2013;12:103-109. PMC3482419. 7. Steward WT, Miege P, Choi K. Charting a moral life: the influence of stigma and filial piety on marital decisions among Chinese men who have sex with men. PLoS One. 2013;8:e71778. PMC3739721.

Additional recent publications of importance to the field (in chronological order)

1. Steward WT, Koester KA, Myers JJ, Morin SF. Provider fatalism reduces the likelihood of HIV prevention counseling in primary care settings. AIDS and Behavior. 2006;10:3-12. 2. Morin SF, Steward WT, Charlebois ED, Remien RH, Pinkerton SD, Johnson MO, Rotheram-Borus MJ, Lightfoot M, Goldstein RB, Kittel L, Samimy-Muzaffar F, Weinhardt L, Kelly JA, Chesney MA. Predicting HIV transmission risk among HIV-infected men who have sex with men: Findings from the Healthy Living Project. Journal of Acquired Immune Deficiencies Syndromes. 2005;40:226-235. 3. Steward WT, Charlebois ED, Johnson MO, Remien RH, Goldstein RB, Wong FL, Morin SF. Receipt of prevention services among HIV-infected men who have sex with men. American Journal of Public Health. 2008;98:1011-1014. PMC2377307. 4. Kelly JA, Morin SF, Remien RH, Steward WT, Higgins JA, Seal DW, Dubrow R, Atkinson JH, Kerndt PR, Pinkerton SD, Mayer KH, Sikkema KJ. Lessons learned about behavioral science and acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: V. AIDS and Behavior. 2009;13:1068-1074. PMC2787956. 5. Steward WT, Remien RH, Higgins JA, Dubrow R, Pinkerton SD, Sikkema KJ, Truong HM, Johnson MO, Hirsch J, Brooks RA, Morin SF. Behavior change following diagnosis with acute/early HIV infection: A move to serosorting with other HIV-infected individuals. The NIMH Multisite Acute HIV Infection Study: III. AIDS and Behavior 2009;13:1054-1060. PMCID: PMC2785897. 6. Arnold EA, Hazelton P, Lane T, Christopoulos KA, Galindo GR, Steward WT, Morin SF. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP) in clinical settings to prevent HIV infection. PLoS One. 2012;7:e40603. PMC3394704. 7. Steward WT, Koester KA, Collins SP, Maiorana A, Myers JJ. The essential role of reconfiguration capabilities in the implementation of HIV-related health information exchanges. International Journal of Medical Informatics. 2012;81:e10-e20. 8. Koester KA, Collins SP, Fuller SM, Galindo GR, Gibson S, Steward WT. Sexual healthcare preferences among gay and bisexual men: a qualitative study in San Francisco, CA. PLoS One. 2013;8:e71546. 9. Hazelton P, Steward WT, Collins SP, Gaffney S, Morin SF, Arnold EA. California's "Bridge to Reform": Identifying challenges and defining strategies for providers and policymakers implementing the Affordable Care Act in low-income HIV/AIDS care and treatment settings. PLoS One. 2014;9:e90306.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2. Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Christopher C Stewart, MD Clinical Professor of Pediatrics EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) Yale University BA 1985 Asian Studies New Haven, Connecticut Keio University MA 1988 Asian History Tokyo, Japan Harvard University MD 1996 Doctor of Medicine Boston, Massachusetts University of California, San Francisco 1999 Pediatric Residency San Francisco, California Pediatric Residency Program San Francisco General Hospital 2000 Chief Residency San Francisco, California Pediatric Residency Program UCSF Training in Clinical Research Program 2003 Certificate in Clinical Research

A. Personal Statement

I have had experience directing a number of global health training programs. Many of my global health education programs focus on interdisciplinary work and the development of teamwork and leadership skills. I directed and was principle investigator for the UCSF/UCB Fogarty/NIH Frameworks program (1R25TW007512 - 01A2), which accepted multidisciplinary teams of students from all the various UCSF schools and the UCB SPH early in their training to develop and work on projects abroad. This program trained the teams of students from different specialties over six months in teamwork and global health issues, and then sent them to various sites to work on a various research, clinical, or service projects or problems proposed by the sites. I am co-PI for Doris Duke Charitable Foundation (DDCF) International Clinical Research Fellowship (ICRF), which supports medical students in year-long global health research experiences. I am also the director of the Pathways to Discovery in Global Health program at UCSF, which incorporates global health education for those in medical school through graduate school or residency, and beyond. The graduate program for this pathway focuses on multidisciplinary education and projects for residents from more than 11 specialties in the school of medicine, as well as the schools of dentistry and pharmacy, and graduate nurses.

Within the various interdisciplinary global health programs I run, I lead sessions on global health leadership and teamwork, as well as ethical concerns involved in clinical work and research. I also teach leadership skills in a low-resource context, including project management, media use for articulating vision to others, negotiating, and cultural humility in communication. I also train mentors who supervise our residents and students on how to be better mentors. I was awarded Velji Award for Teaching Excellence in Global Health (Global Health Education Consortium) for my global health educational work as well as other awards for teaching. I was awarded the UCSF Chancellor’s Award for public service in 2004, and Jane Addams Award for Social Justice in 2010.

I mentor numerous pediatric residents for their international health research and project work, as well as numerous medical students. Pediatric residents I have mentored in the past few years are doing research in pediatric HIV, tuberculosis, malaria and other parasitic diseases, and malnutrition, and in leadership positions at USAID, CDC, and a number of academic institutions. I also have a specialty in child maltreatment. I have given numerous lectures abroad, and have administered training programs in child and neonatal health in international settings, including Asia, Central America, and Africa.

B. Positions and Honors.

Positions and Employment 1996-97 Intern, Department of Pediatrics, University of California, San Francisco, San Francisco, CA 1997-99 Resident Physician, Department of Pediatrics, University of California, San Francisco, San Francisco, CA 1999-2000 Chief Resident, Department of Pediatrics, San Francisco General Hospital, San Francisco, CA 2001-2003 Clinical Instructor of Pediatrics, University of California, San Francisco 2001-2003 Interim Medical Director, San Francisco General Hospital, Inpatient Pediatric Service 2003-present Assistant Clinical Professor of Pediatrics, University of California, San Francisco 2003-present Medical Director, San Francisco General Hospital, Inpatient Pediatric Service 2003-present Medical Director, Suspected Child Abuse and Neglect Team, City of San Francisco 2006-present Director, Global Health Clinical Scholars Program, Global Health Sciences 2006-present Director, Medical Student rotation in Child Abuse 2006-present Co-director, Shaken Baby Prevention Project 2008-2011 Director, Frameworks Program 2008-present Director, Pathways to Discovery in Global Health

Other Experience CAMPUS-WIDE 2001-present Resident/Student Preceptor, Urgent Care Clinic, San Francisco General Hospital 2001-present Resident/Student Preceptor, Inpatient Pediatric Ward, San Francisco General Hospital 2001-present Clinical Preceptor, Pediatric Preceptorship (6-8 students/year for longitudinal elective) 2001-2004 Longitudinal Clinical Experience for medical students 2003-2004 Admissions Committee School of Medicine 2004-2005 Mission Bay Medical Rebuild Committee, Inpatient Pediatrics Subcommittee 2005 Precepting mini-Clinical Performance Exam for medical students 2005-2007 Chancellor’s nomination committee for Public Service Awards 2006-present Steering Committee of UCSF Global Health Sciences 2006-present Director, Global Health Clinical Scholars Program, Global Health Sciences 2007-2008 Co-convener, Dean’s Pathways Program, Global Health Pathway 2008-present Director, Pathways to Discovery in Global Health 2008-present Director, UCSF-UCB Frameworks Program 2008-present Campus Fulbright Program Adviser 2012-present Co-PI, Doris Duke International Research Training Grant

Professional Membership 1996-present American Academy of Pediatrics 2003-present Section on International Health, AAP 2003-present Section on Child Maltreatment, AAP 2005-present Fellow, American Academy of Pediatrics 2007-present Member, Ray Helfer Professional Society

Honors 1985 Graduated Magna cum Laude, Yale College, New Haven, CT 1998 French Foundation Award for Medical Research and Education 2004 Chancellor’s Award for Public Service- Honored for work done in Vietnam 2006 Academy of Medical Educators Award for Excellence in Direct Teaching and Curricular Design 2009 Alpha Omega Alpha Society election by graduating medical school class 2009 The Velji Award for Teaching Excellence in Global Health (Global Health Education Consortium) 2010 Jane Addams Award for Social Justice

Biographical Sketch Page 2

C. Selected peer-reviewed publications (in chronological order). PEER REVIEWED PUBLICATIONS

1. Stewart CC, Solomons N, Mendoza I. Salt iodine variation within an extended Guatemalan community: The failure of intuitive assumptions. Food and Nutrition Bulletin. 1996;17(3):258-261.

2. Stewart, CC. Multiple Teaching Strategies, Varied Activities: Key Components of a Child Abuse Curriculum, Western Group on Educational Affairs. 2006

3. Stewart, CC. Building an Interdisciplinary Global Health Program, Western Group on Educational Affairs. 2007

4. Macfarlane SB, Agabian N, Novotny TE, Rutherford GW, Stewart CC, Debas HT. Think globally, act locally, and collaborate internationally: global health sciences at the University of California, San Francisco. Acad Med. 2008 Feb; 83(2):173-9.

5. Stewart, CC. UCSF Global Health Clinical Scholars Program: A novel multidisciplinary global health education program. The Consortium of Universities for Global Health (CUGH) Annual Meeting. 2009

6. Lion KC, Prata N, Stewart CC. Adolescent childbearing in Nicaragua: A quantitative assessment of associated factors. International Perspectives on Sexual and Reproductive Health. 2009,35(2):91-96.

7. Stewart CC, T. Humbert-Rico, H. Leslie, E. Schindelman. Complex Humanitarian Emergency (CHE) Leadership Training Program: Development and Evaluation. Western Regional International Health Conference. 2010

8. Stewart, CC, Evaluating a Complex Humanitarian Emergency (CHE) Leadership Training Program, Consortium for Universities in Global Health. 2010

9. Richard Dunning, Suzinne Pak-Gorstein, Stewart CC. Global Health survey of professional health trainees at four US universities. Consortium for Universities in Global Health. 2010

10. Hsiang MS, Carlton EJ, Zhang Y, Zhong B, Dongchuan Q, Cohen PA, Stewart CC, Spear RC. Use of ultrasonography to evaluate Schistosoma japonicum-related morbidity in children, Sichuan Province, China, 2000-2007. Am J Trop Med Hyg. 2010 Jan; 82(1):103-11.

11. P Suchdev, C Schubert, S Pak-Gorstein, C Howard, S Wagner, M Anspacher, Stewart CC, D Kamat, M Batra, JGutman. A Model Curriculum in Global Health for Pediatrics Residents. Consortium for Universities in Global Health. 2011

12. Stewart, CC. Complex Humanitarian Emergency Training: A platform to evaluate Global Health leadership competencies. Consortium for Universities in Global Health. 2011

13. A. Chang, K. Fiorella, T. Tran, C. Stewart, Craig Cohen. Qualitative analysis of the intersection of HIV and socioeconomic factors impacting community health on Mfangano Island, Lake Victoria Region, Kenya. Consortium for Universities in Global Health. 2011

14. Suchdev PS, Shah A, Derby KS, Hall L, Schubert C, Pak-Gorstein S, Howard C, Wagner S, Anspacher M, Staton D, O'Callahan C, Herran M, Arnold L, Stewart CC, Kamat D, Batra M, Gutman J.. A proposed model curriculum in global child health for pediatric residents. Acad Pediatr. 2012 May;12(3):229-37. Epub 2012 Apr 7.

C. Research Support. 2008-2011 Fogarty International Frameworks Grant (NIH) (1R25TW007512 - 01A2), PI 2009-2011 Supplemental Grant to Frameworks Grant (NIH), PI 2012-2017 Co-PI, Doris Duke International Research Training Grant

Biographical Sketch Page 3 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Thompson, Lisa Marie Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) LISATHOM EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) BA, Tulane University 06/84 Latin American Studies Cum Laude San Francisco State University BS/MS 06/91 Nursing Family Nurse San Francisco State University FNP 06/96 Practitioner Environmental Health University of California, Berkeley MS 06/04 Sciences Environmental Health University of California, Berkeley PhD 06/08 Sciences

A. Positions and Honors Positions and Employment 1990-1993 RN and Program Director, Clinical Health Education, La Clínica de la Raza, Oakland 1993-1995 RN and Section Supervisor, Pediatrics, La Clínica de la Raza, Oakland 1995-1996 Clinical Nurse II, Triage, Alameda County Ambulatory Care Services 1996-2008 Family Nurse Practitioner, Family Medicine & Women's Clinics, La Clínica de la Raza, Oakland 1999-2000 Asthma Care Coordinator, Family Medicine, La Clínica de la Raza, Oakland 2000-2000 Clinical Researcher I, Genetics of Asthma in Latinos (GALA) study, University of California, San Francisco 2002-2008 Graduate Student Researcher, Environmental Health Sciences; RESPIRE/CRECER studies, University of California, Berkley 2004-2006 Teaching Assistant, Environmental Science Policy and Management; School of Public Health , University of California, Berkley 2008-present Assistant Professor, Family Health Care Nursing, University of California, San Francisco 2008-present Faculty member, Center for Occupational and Environmental Health 2009-present Faculty scholar, Global Health Sciences, UCSF 2011-present Faculty K scholar, Clinical Translational Science Institute, UCSF

Other Experience and Professional Memberships 1988-present Sigma Theta Tau International, Nursing Honor Society 1993-present American Public Health Association 1996-2000 California Coalition of Nurse Practitioners 2008-present National Organization of Nurse Practitioner Faculties (NONPF) 2009-2013 Grant Reviewer, Sigma Theta Tau Research Award, Alpha Eta Chapter 2010-2010 International Research Proposals Reviewer , Health Effects Institute, Boston MA 2010-present Western Institute of Nursing 2010-present International Society of Environmental Epidemiology

Honors 2002 Center for Occupational and Environmental Health Program Student Research Award, University of California, Berkeley 2003 Fellow, Superfund Basic Research Program, National Institute of Environmental Health Sciences 2007 UC Berkeley Mentee, University of California Women Professional and Graduate Student Leadership Conference, University of California 2008 Fellow, Summer Institute for Future Faculty, University of California, Berkeley 2008 Henrik L. Blum Award for Distinguished Social Action, School of Public Health, University of California, Berkeley 2009 Burke Family Global Health Faculty Award, UCSF Global Health Sciences 2009 Faculty Development Award, UCSF Academic Senate 2009 NIH Health Disparities Loan Repayment Program Award, National Institutes of Health 2010 Service Award, San Lorenzo Ministry of Health, San Marcos, Guatemala 2011 CTSI KL2 Career Development Award in Multidisciplinary Clinical Research, UCSF Clinical and Translational Science Institute 2012 Service Award, San Lorenzo Ministry of Health, San Marcos, Guatemala

B. Selected Peer-Reviewed Publications 1. Smith-Siversten T, Diaz E, Bruce N, Diaz A, Khalakdina A, Schei MA, McCracken J, Arana B, Klein R, Thompson L, Smith KR. Reducing indoor air pollution with a randomized intervention design - A presentation of the Stove Intervention Study in the Guatemalan Highlands. Norsk Epidemiologi. 2004 14(2): 137-143. 2. Bruce N, Diaz A, Arana B, Jenny A, Thompson L, Weber M, McCracken JM, Dherani D, Juarez D, Ordonez S, Klein R, Smith KR. Pneumonia case-finding in the Guatemala indoor air pollution trial (RESPIRE): Standardizing methods for resource-poor settings. Bull World Health Organ. 2007 Jul; 85(7):535-44. PMCID: PMC2636369 3. Thompson L, Diaz J, Diaz A, Jenny A, Bruce N, Balmes JR. Nxwisen, ntzarrin or ntzolin? Mapping children's respiratory symptoms among indigenous populations in Guatemala. Soc Sci Med. 2007 Oct; 65(7):1337-50. PMCID: PMC2040052 4. Pope DP, Mishra V, Thompson L, Siddiqui AR, Rehfuess E, Weber M, Bruce NG. Systematic review and meta-analyses of risk of low birth weight and stillbirth associated with indoor air pollution in developing countries. Epidemiol Rev. 2010 Apr; 32(1): 70-81. PMID: 20378629 5. Smith KR, McCracken J, Thompson L, Edwards R, Naumoff-Shields K, Canuz E, Bruce N. Personal Carbon Monoxide Exposures in Infants and Mothers: Methods and Results from A Randomized Trial of Improved Wood-fired Cookstoves in Guatemala (RESPIRE). J Expo Sci Environ Epidemiol. 2010 Jul; 20(5): 406-16. PMID: 19536077 6. Thompson LM, Clark M, Cadman B, Canuz E, Smith KR. 2011. Exposures to high levels of carbon monoxide from wood-fired temazcal (steam bath) use in highland Guatemala. Int J Occup Environ Health. 2011 Apr-Jun;17(2):103-12. PMID: 19536077 7. Thompson LM, Bruce N, Eskenazi B, Diaz A, Pope D, Smith, KR. Maternal exposures to wood fuel smoke and newborn birth weight: Results from RESPIRE, a randomized trial of chimney cook stoves in Guatemala. Environmental Health Perspectives. 2011 Oct; 119 (1): 1489–1494. PMCID: PMC3230429 8. Lam N, Nicas M, Ruiz-Mercado I, Thompson LM, Smith K. Non-invasive measurement of carbon monoxide burden in Guatemalan children and adults following wood-fired temazcal (sauna-bath) use. Journal of Exposure Monitoring. 2011 Aug; 13(8): 2172-81. PMID: 21687856 9. Kuo D, Thompson LM, Lee A, Romero C, & Smith KR. Unintended benefits: Leadership Skills and behavioral change among Guatemalan Fieldworkers employed in a longitudinal household air pollution study. Int’l. Quarterly of Community Health Education, 2010-2011, Vol. 31(4) 311-330. PMID: 22192940 10. Smith KR, McCracken JP, Weber MW, Hubbard A, Jenny A, Thompson LM, Balmes J, Diaz A, Arana B, Bruce N. (2011). Effect of reduction in household air pollution on childhood pneumonia in Guatemala (RESPIRE): A randomised controlled trial. Lancet, 378(9804), 1717-1726. PMID: 22078686 11. Chandler, JT, Malone, RE, Thompson, LM, Rehm, RS. “No Me Ponıan Mucha Importancia” Care-Seeking Experiences of Undocumented Mexican Immigrant Women With Chronic Illness.Advances in Nursing Science, 2012, 35(2), 1–13. PMID: 22565795 12. Radoff K, Levi A, Levy F, Thompson LM. From home to hospital: Mistreatment of childbearing women and barriers to facility-based birth in Nicaragua. International Journal of Childbirth, 2012, 2(1), 40-50. 13. Speaks, JT, Thomas, EC, Thompson, LM. Household Air Pollution from Cooking Fires: A Challenge for Nurses Globally and A Call to Action. J Community Health Nurse. 2012; 29(4), 236-244. PMID: 23136863 14. Radoff K, Thompson, LM, Bly, KC, Romero, C. Practices related to postpartum uterine involution in the Western Highlands of Guatemala. Midwifery, 2013, March 29(3): 225-232 PMCID: PMC3799972 15. Thompson, LM, Jarvis, S, Sparacino, P, Kuo, D, Genz, S. Perceptions of health equity and subjective social status among baccalaureate nursing students engaged in service-learning activities in Hawai’i. Hawai‘i Journal of Medicine & Public Health, 2013, October 72(10): 4-10.PMCID: PMC3796782 16. Thompson, LM, Levi, AJ, Bly, KC, Ha, C, Keirns, T. & Romero, C. Premature or just small Training Guatemalan traditional birth attendants to weigh and assess gestational age of newborns: An analysis of outcomes. Health Care for Women International, 2013, DOI:10.1080/07399332.2013.829066 17. Radoff K, Levi, AJ, Thompson LM. Mairin Karnakira-Mujer Poderosa: A radio-education intervention to improve maternal knowledge of obstetric danger signs. Revista Panamericana de Salud Pública/Pan American Journal of Public Health, 2013, 34(4): 213-219.

C. Research Support On-going Research Support 8 KL2 TR000143-08 (Johnston) 09/30/2006-06/30/2016 NCATS vClinical and Translational Science Institute (CTSI) The goal of the CTSI KL2 career development award is to increase the number and quality of clinical and translational investigators skilled at leading multidisciplinary research teams. My role is as a KL2 Scholar, for which I receive salary support for 9 calendar months, plus research funds. Role: Faculty Scholar

S-6 0515-01-10 06/01/2014 - 12/01/2014 Grand Challenges Canada, Stars in Global Health, Phase I GenteGas: Delivering affordable gas stoves and household health education to low-income families exposed to toxic levels of woodsmoke Role: co-PI

Completed Research Support R01 ES10178-04 Smith (PI) 06/01/2001-05/31/2005 NIH/ NIEHSv RESPIRE- Indoor Air Pollution and Child ARI: A Randomized Trail (Guatemala) Smith (PI) Role: Graduate Student Researcher R01 ES10178-04 Smith (PI) 09/15/2006-08/31/2010 NIH/NIEHSv CRECER- Chronic Respiratory Effects of Early Life PM Exposure Smith (PI) Role: Graduate Student Researcher UCSF School of Nursing Intramural Award Thompson (PI) 02/27/2009- 02/28/2010 Feasibility study: Building capacity among traditional birth attendants and field workers to assess newborn gestational age and anthropometry in Guatemala Role: PI UCSF Faculty Development Award 07/01/2009-06/30/2010 ACCESS 1) To conduct focus groups and individual interviews over a 4-week period with local Guatemalan field workers, traditional birth attendants and health facility medical staff to ascertain ability to identify and recruit women in the first trimester of pregnancy and assess gestational age. Role: PI D09HP00570 Thompson (PI) 07/01/2010-06/30/2012 HRSAv PrimeRisk III Nursing Education Grant Training grant for FNP pogram; focus on immigrant populations Role: Project Director Loan Repayment Program Thompson (PI) 07/01/2009-06/30/2011 NIH/ NCMHD--Health Disparities Research vIndoor air pollution as a predictor of perinatal outcomes in Guatemala Loan repayment program for health disparities researchers Role: PI UCSF Resource Allocation Program 02/01/2013-01/31/2014 Resource Allocation Programv NACER-Neurodevelopment and anthropometric growth of infants exposed to household air pollution in rural Guatemala: A pilot study for a future clean stove/behavioral change intervention trial Bridge funding to support current NACER study and develop tools for behavioral change intervention for a future clean stove/behavioral change intervention trial Role: PI UCSF Global Health Sciences Faculty Award Thompson (PI) 07/01/2009- 06/30/2013 Burke Family Gift Fundv Conduct an epidemiologic study of the impact of wood smoke exposures on birth/neonatal outcomes in Guatemala and/or Peru. Assess environmental health curricula in Latin American nursing schools and auxiliary health worker training programs, including environmental health education targeting the pregnancy and neonatal periods. Role: PI

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Vlahov, David Dean and Professor eRA COMMONS USER NAME (credential, e.g., agency login) DVLAHOV EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Earlham College, Richmond, IN B.A. 1974 History University of Maryland, Baltimore, MD B.S.N. 1977 Nursing University of Maryland, Baltimore, MD M.S. 1980 Nursing The Johns Hopkins University, Baltimore, MD Ph.D. 1988 Epidemiology

A. Personal Statement As a collaborator for the proposed UC Global Health PhD program, I bring a record of research, teaching and service that may be considered for the role. I have been a NIDA funded researcher for over 23 years and received a NIDA MERIT Award. My research has included medical consequences of drug abuse, epidemiology of substance abuse and prevention, violence and mental health. I have a background in mental health research after disasters. I have received the Golden Apple Award for teaching twice while at Hopkins. I been primary doctoral or post doctoral advisor for 25 successful researchers and academicians; have served on multiple pre-doctoral committees; been primary or support mentor on multiple NRSA, NIH Minority supplements and K awards and mentored junior faculty into Professorships and independent research careers. I have assembled multi-disciplinary teams including epidemiology, biostatistics, genetics, immunology, economics, behavioral and social sciences.

B. Positions and Honors 1988-91 Assistant Professor of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD. 1990-01 Joint Appointment, The Johns Hopkins School of Medicine, Baltimore, MD. 1990-97 Reviewer, DAAR-1 Study Section, National Institute on Drug Abuse; NIDA Council 2001-2004. 1991-96 Associate Professor of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD. 1996-01 Professor of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD. 1999-11 Professor of Clinical Epidemiology, Mailman School of Public Health Columbia University, NY NY. 1999-11 Director, Center for Epidemiologic Studies, The New York Academy of Medicine, New York, NY. 2006-11 Senior Vice President for Research, The New York Academy of Medicine, New York, NY. 2001-11 Executive Committee, NIAID HIV Prevention Trials Network (HPTN) 2007-11 Co-Director, National Program Office, RWJF Health and Society Scholars Program. 2011- Dean and Professor, UCSF School of Nursing, San Francisco, CA Honors: National Heart Lung and Blood Institute Traineeship, 1985-86 Fellow, The New York Academy of Medicine, 1998. Ruth B.Freeman Award - The Johns Hopkins University, 1988 Fellow, Infectious Disease Society of America,1999. Delta Omega National Merit Award, 1988 Johns Hopkins Distinguished Alumni Award 2011 American Epidemiological Society, 1995 Member, Institute of Medicine, NAS 2012 MERIT Award, NIH, 1996-2006

Selected Peer-reviewed Publications (from a list of 634)

C. Most relevant to the current application 1.Cook RL, Zhu F, Belnap BH, Weber KM, Cole SR, Vlahov D, Cook JA, Hessol NA, Wilson TE, Plankey M, Howard AA, Sharp GB, Richardson JL, Cohen MH. Alcohol Consumption Trajectory Patterns in Adult Women with HIV Infection. AIDS Behav. 2012 Jul 27. [Epub ahead of print] 2.Ompad DC, Friedman SR, Hwahng SJ, Nandi V, Fuller CM, Vlahov D. HIV risk behaviors among young drug using women who have sex with women (WSWs) in New York City. Subst Use Misuse. 2011;46(2-3):274-84. 3.Panchanadeswaran S, Frye V, Nandi V, Galea S, Vlahov D, Ompad D. Intimate partner violence and consistent condom use among drug-using heterosexual women in New York City. Women Health. 2010 Mar;50(2):107-24 4.Frye V, Ompad D, Chan C, Koblin B, Galea S, Vlahov D. Intimate partner violence perpetration and condom use-related factors: associations with heterosexual men's consistent condom use. AIDS Behav. 2011 Jan;15(1):153-62. 5.Ghebremichael M, Paintsil E, Ickovics JR, Vlahov D, Schuman P, Boland R, Schoenbaum E, Moore J, Zhang H. Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV. AIDS Care. 2009 Jul;21(7):834-41. doi: 10.1080/09540120802537864. 6.Cook RL, Zhu F, Belnap BH, Weber K, Cook JA, Vlahov D, Wilson TE, Hessol NA, Plankey M, Howard AA, Cole SR, Sharp GB, Richardson JL, Cohen MH. Longitudinal trends in hazardous alcohol consumption among women with human immunodeficiency virus infection, 1995-2006. Am J Epidemiol. 2009 Apr 15;169(8):1025-32. Epub 2009 Mar 6. 7.Cook JA, Burke-Miller JK, Cohen MH, Cook RL, Vlahov D, Wilson TE, Golub ET, Schwartz RM, Howard AA, Ponath C, Plankey MW, Levine AM, Grey DD. Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women. AIDS. 2008 Jul 11;22(11):1355-63. Erratum in: AIDS. 2008 Sep 12;22(14):i. Levine, Andrea [corrected to Levine, Alexandra M]. 8.Kapadia F, Vlahov D, Wu Y, Cohen MH, Greenblatt RM, Howard AA, Cook JA, Goparaju L, Golub E, Richardson J, Wilson TE. Impact of drug abuse treatment modalities on adherence to ART/HAART among a cohort of HIV seropositive women. Am J Drug Alcohol Abuse. 2008;34(2):161-70. 9.Vlahov D, O'Driscoll P, Mehta SH, Ompad DC, Gern R, Galai N, Kirk GD. Risk factors for methadone outside treatment programs: implications for HIV treatment among injection drug users. Addiction. 2007 May;102(5):771-7. 10.Semba RD, Ricketts EP, Mehta S, Netski D, Thomas D, Kirk G, Wu AW, Vlahov D. Effect of micronutrients and iron supplementation on hemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trial. J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):298-303. 11.Semba RD, Ricketts EP, Mehta SF, Kirk GD, Latkin C, Galai N, Vlahov D. Adherence and retention of female injection drug users in a phase III clinical trial in inner city Baltimore. Am J Drug Alcohol Abuse. 2007;33(1):71-80. 12.Cook JA, Grey DD, Burke-Miller JK, Cohen MH, Vlahov D, Kapadia F, Wilson TE, Cook R, Schwartz RM, Golub ET, Anastos K, Ponath C, Goparaju L, Levine AM. Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women. Drug Alcohol Depend. 2007 Jun 15;89(1):74-81. Epub 2007 Feb 8. 13.Ickovics JR, Milan S, Boland R, Schoenbaum E, Schuman P, Vlahov D; HIV Epidemiology Research Study (HERS) Group. Psychological resources protect health: 5-year survival and immune function among HIV-infected women from four US cities. AIDS. 2006 Sep 11;20(14):1851-60. 14. Cofrancesco J Jr, Shah N, Ghanem KG, Dobs AS, Klein RS, Mayer K, Schuman P, Vlahov D, Rompalo AM. The effects of illicit drug use and HIV infection on sex hormone levels in women. Gynecol Endocrinol. 2006 May;22(5):244-51.

D. Research Support (Current and recently completed)

RO1(Koblin) 09/01/09 – 08/30/14 NIAIDS Community Factors, HIV and Related Health Outcomes in New Who Have Sex with Men A cross sectional study of MSM to explore the influence of neighborhood of residence on sexual risk behaviors, drug use and depression.

1R24 MD002754-01 (Vlahov) 05/22/08 – 01/31/14 NCMHD Harlem Community Academic Partnership: Influenza Immunizations A community based participatory research project (CBPR) and evaluation for improving influenza immunizations in high risk populations within disadvantaged minority communities

1R21 MH 081173-01A1 (Ompad) 03/01/08 – 02/28/10 NIMH Methods for Evaluating the Physical and social Environments of Urban Neighborhoods The purpose of this study is to design and evaluate a comprehensive, systematic approach to characterizing urban neighborhoods through direct observation of neighborhood characteristics

1U58 DP000943-01 (Calman) CDC 9/29/07 – 9/28/12 New York REACH CEED Racial and Ethnic Approaches to Community Health US An evaluation program designed to develop community capacity to eliminate racial and ethnic disparities in health.

5R01 DA022123-02 (Vlahov) 09/20/07 – 07/31/12 NIDA Heroin Cessation and HIV Risk: A Case-Control Study The purpose of this case-control study is to characterize the prognostic indicators, including HIV infection, for the positive outcome of sustained heroin cessation among persons with a prior history of chronic heroin use within economically disadvantaged, predominantly racial/ethnic minority neighborhoods in New York City.

1R01 DA022144-01A2 (Fuller) 09/01/07 - 08/31/11 NIDA Pharmacy Referral Intervention: IDU Access to Services Using community-based participatory research, this intervention will connect pharmacies with community-based organizations to assist pharmacy staff in the provision of harm reduction information to injection drug users who purchase syringes from pharmacies through the NYS Expanded Syringe Access Demonstration Program (ESAP)

5R37 DA04334 (Kirk) 12/01/06 - 11/30/11 NIDA Natural History of HIV Infection among Drug Users (ALIVE) Determine the natural history if HIV infection in a cohort of seropositive HIV drug users

1R01 DA017004-01A1 (Vlahov) 09/30/03 - 06/30/08 NIDA Rapid Vaccination of Hard to Reach Populations. Proposed is a quasi experimental design involving community participatory intervention that is designed to rapidly immunize hard to reach (HRT) populations in disadvantaged minority communities.

Program Director/Principal Investigator (Last, First, Middle): Volberding, Paul A.

NAME POSITION TITLE Volberding, Paul A. Professor of Medicine eRA COMMONS USER NAME (credential, e.g., agency login) VOLBERDING EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of Chicago BA 1967-1971 Biology University of Minnesota MD 1971-1975 Medicine University of Utah Medical Center Residency 1975-1978 Internal Medicine University of California, San Francisco Fellowship 1978-1981 Hematology/Oncology

A. Personal Statement

Dr. Paul Volberding is a Professor of Medicine at the University of California, San Francisco, the Director of the AIDS Research Institute, Research Director of Global Health Sciences and the Principal Investigator and Co- Director of the UCSF-Gladstone Center for AIDS Research. Dr. Volberding Chairs the Scientific Advisory Board of the Infectious Disease Institute of Makerere University in Kampala Uganda. He received his undergraduate and medical degrees at the University of Chicago and the University of Minnesota, respectively, and finished training at the University of Utah and the University of California, San Francisco, where he was boarded in Medical Oncology. Dr. Volberding served as the Chief of Oncology at San Francisco General Hospital and founded the HIV/AIDS program there initially based on his extensive work with AIDS-related malignancies, particularly Kaposi’s sarcoma. He was until recently the Chief of the Medical Service at the San Francisco VA Medical Center. While his career has primarily focused on the development of antiretroviral therapy for HIV infection, Dr. Volberding has remained involved in a broad range of HIV-related issues. Dr. Volberding interacts and mentors many residents and fellows including those in infectious diseases and oncology. Under his leadership the UCSF-Gladstone CFAR has developed a strong program of support to early career stage investigators through pilot grant awards and a leading mentorship effort. In that capacity and as the Chair of the Scientific Advisory Board for the Infectious Disease Institute of Makerere University in Kampala Uganda, he has encouraged the expansion of international research through NIH CFAR supplements and co-hosted a pan-CFAR Sub-Saharan Africa Scientific Symposium in Uganda in 2011.He served as the liaison to the VA Medical Center for the UCSF Comprehensive Cancer Center. He is the co-editor in chief of the Journal of Acquired Immune Deficiency Syndrome, and a founder of HIV InSite, a comprehensive source of HIV information. He served as Co-Editor of the major textbook, Global HIV/AIDS Medicine. He is the founder and Chair of the Board of the International Antiviral Society - USA. He has served as the President of the HIV Medical Association of the IDSA and of the International AIDS Society. He was elected a member of the Institute of Medicine of the National Academy of Sciences in 1999.

B. Positions and Honors

Positions and Employment 1968-1971 Virology Laboratory Assistant, Dr. Marc Beem, University of Chicago 1971-1975 University of Minnesota School of Medicine Avian type C virus receptor research, Dr. Charles Moldow 1975-1978 Medicine Internship and Residency, University of Utah Medical Center, Salt Lake City 1978-1979 Clinical Fellow in Hematology/Oncology, University of California, San Francisco Clinical research conducted with Dr. Michael Friedman on therapy of hepatic tumors

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Volberding, Paul A. 1979-1981 Research Fellow in Hematology/Oncology, University of California, San Francisco Research conducted in the laboratory of Dr. Jay A. Levy studying mechanisms controlling infection with xenotropic type C retroviruses 1981-1986 Assistant Professor of Medicine, University of California, San Francisco 1981-2001 Chief, Medical Oncology Division, San Francisco General Hospital 1984-2001 Director, AIDS Program, San Francisco General Hospital 1986-1990 Associate Professor of Medicine, University of California, San Francisco 1988-Present Director, UCSF-GIVI Center for AIDS Research, University of California, San Francisco 1990-Present Professor of Medicine, University of California, San Francisco 2001-2012 Vice Chair, Department of Medicine, University of California, San Francisco 2001-2012 Chief of the Medical Service, San Francisco Veterans Affairs Medical Center 2010-Present Director, Global Health Program, UCSF Clinical and Translational Sciences Institute 2012-Present Director, UCSF AIDS Research Institute 2012-Present Research Director, UCSF Global Health Sciences

Other Experience and Professional Memberships 1982-Present American College of Physicians-Fellow (1994) 1982-Present American Association for the Advancement of Science (Fellow, 1995) 1986-Present Western Society of Clinical Investigation 1988-Present International AIDS Society (Founding Director and Past President, 1990-1992) 1988-Present NIH / DHHS Guidelines for Use of Antiretroviral Drugs-Panel Member 1988-Present The Journal of the Acquired Immune Deficiency Syndromes (Co-Editor-In-Chief) 1990-Present HIV InSite (http://hivinsite.ucsf.edu), Director 1993-Present Founder and Board Chair, International Antiviral Society - USA, Inc. 1994-Present Association of American Physicians 1999-Present Institute of Medicine of the National Academy of Sciences 2000-Present HIV Medicine Association of the IDSA (President, 2003-2005) 2002-2004 University of Chicago Alumni Association, Board of Governors (President) 2004-2009 Physicians for Human Rights / Health Action AIDS 2004-Present PANGAEA Global AIDS Foundation, Board of Directors 2006-2011 Office of AIDS Research (NIH) Advisory Council 2007-2011 Chair DSMB NIAID Clinical Trials (Asia) 2012-Present Chair DSMB NIAID Co-Morbidities and Co-Infections in HIV 2001-Present Northern California Institute for Research and Education Executive Board (Board of Directors Chair 2008-Present)

C. Selected peer-reviewed publications

Most relevant to the current application

1. Volberding PA, Deeks SG. Antiretroviral therapy and management of HIV infection. Lancet. 376: 49-62, Jul/3/2010. 2. Martin J, Volberding P. HIV and premature aging: A field still in its infancy. Ann Intern Med. 2010 Oct 5; 153(7):477-9. 3. High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, Deren S, Effros RB, Gebo K, Goronzy JJ, Justice AC, Landay A, Levin J, Miotti PG, Munk RJ, Nass H, Rinaldo CR, Shlipak MG, Tracy R, Valcour V, Vance DE, Walston JD, Volberding P. HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. J Acquir Immune Defic Syndr. 2012 Jul 1; 60 Suppl 1:S1-18. 4. Thompson MA, Aberg JA, Hoy JF, Telenti A, Benson C, Cahn P, Eron JJ, Günthard HF, Hammer SM, Reiss P, Richman DD, Rizzardini G, Thomas DL, Jacobsen DM, Volberding PA. Antiretroviral Treatment of Adult HIV Infection: 2012 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2012 Jul 25; 308(4):387-402.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Volberding, Paul A. 5. El-Sadr WM, Morrison JS, Quinn T, Volberding P. A chronicle of hope and promise: the world as it was, as it is, and as it can be. J Acquir Immune Defic Syndr. 2012 Aug 15; 60 Suppl 3:S49-50.

Additional recent publications of importance to the field (in chronological order)

6. Volberding PA, Lagakos SW, Grimes JM, Stein DS, Rooney J, Meng T-C, Fischl MA, Collier AC, Phair JP, Hirsch MS, Hardy WD, Balfour HH, Reichman RC, for the AIDS Clinical Trials Group. A comparison of immediate with deferred zidovudine therapy for asymptomatic HIV-infected adults with CD4 cell counts of 500 or more per cubic millimeter. NEJM 1995, 333:7:401-407. 7. Volberding PA. Opportunities and Options for Treatment Research in Resource-Constrained Settings. Clinical Infectious Diseases, 2003. 37:Supp 1:S1-S3. 8. Chung RT, Andersen J, Volberding PA, Robbins GK, Lui T, Sherman KE, Peters MG, Koziel MJ, Alston B, Colquhoun D, Nevin T, Harb G, van der Horst C. A comparison of of peg-interferon alfa-2A plus ribavirin vs. interferon alfa-2A plus ribavirin for chronic hepatitis c virus infection in HIV-co-infected persons: The US clinical trials group A5071 study team. NEJM 2004, 351:5:451-459. 9. Volberding PA. The New York Case, Lessons Learned. Ann Intern Med 2005. 142:10:866-868. 10. Behler C, Shade S, Gregory K, Abrams D, Volberding PA. Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone. AIDS Res Hum Retroviruses 2005. 21:3:200-206. 11. Holodniy M, Hornberger J, Rapoport D, et al. Relationship between antiretroviral prescribing patterns and treatment guidelines in treatment-naive HIV-1-infected US veterans (1992-2004). J Acquir Immune Defic Syndr 2007;44(1):20-9. 12. Behler CM, Vittinghoff E, Lin F, et al. Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects. Clin Infect Dis 2007;44(10):1375-83. 13. Choi AI, Rodriguez RA, Bacchetti P, et al. Low rates of antiretroviral therapy among HIV-infected patients with chronic kidney disease. Clin Infect Dis 2007;45(12):1633-9. 14. Choi AI, Rodriguez RA, Bacchetti P, Bertenthal D, Volberding PA, O'Hare AM. Racial differences in end- stage renal disease rates in HIV infection versus diabetes. J Am Soc Nephrol 2007;18(11):2968-74. 15. Choi AI, Rodriguez RA, Bacchetti P, Bertenthal D, Volberding PA, O'Hare AM. The impact of HIV on chronic kidney disease outcomes. Kidney Int 2007;72(11):1380-7. 16. Hammer SM, Eron JJ, Jr., Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. Jama 2008;300(5):555-70. 17. Anis AH, Nosyk B, Sun H, Guh DP, Bansback N, Li X, Barnett PG, Joyce V, Swanson KM, Kyriakides TC, Holodniy M, Cameron DW, Brown ST; OPTIMA Team1. Quality of life of patients with advanced HIV/AIDS: measuring the impact of both AIDS-defining events and non-AIDS serious adverse events. J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):631-9. 18. Volberding P. Cohorts, trials, and evidence: expanding our confidence in guidelines for antiretroviral resistance testing. Ann Intern Med. 2009 Jul 21;151(2):135-6. 19. Volberding P, Demeter L, Bosch RJ, Aga E, Pettinelli C, Hirsch M, Vogler M, Martinez A, Little S, Connick E; ACTG 371 Team. Antiretroviral therapy in acute and recent HIV infection: a prospective multicenter stratified trial of intentionally interrupted treatment. AIDS. 2009 Sep 24;23(15):1987-95. PMID: 19696651 20. Linzer M, Warde C, Alexander RW, Demarco DM, Haupt A, Hicks L, Kutner J, Mangione CM, Mechaber H, Rentz M, Riley J, Schuster B, Solomon GD, Volberding P, Ibrahim T,. Part-time careers in academic internal medicine: a report from the association of specialty professors part-time careers task force on behalf of the alliance for academic internal medicine. Acad Med. 84: 1395-400, Oct/2009. 21. Thompson MA, Aberg JA, Cahn P, Montaner JS, Rizzardini G, Telenti A, Gatell JM, Gunthard HF, Hammer SM, Hirsch MS, Jacobsen DM, Reiss P, Richman DD, Volberding PA, Yeni P, Schooley RT,. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel. JAMA. 304:321-33, Jul/21/2010. 22. Dykes C, Mukherjee AL, Bosch RJ, Connick E, Volberding PA, Demeter LM. Prevalence of primary resistance at baseline in acutely and recently infected subjects enrolled in AIDS clinical trials group protocol 371. J Acquir Immune Defic Syndr. 55: 132-4, Sep/1/2010. 23. Choi AI, Li Y, Parikh C, Volberding PA, Shlipak MG. Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int. 78: 478-85, Sep/2010. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Volberding, Paul A. 24. Tabas JA, Boscardin C, Jacobsen DM, Steinman MA, Volberding PA, Baron RB. Clinician attitudes about commercial support of continuing medical education: results of a detailed survey. Arch Intern Med. 2011 May 9; 171(9):840-6. 25. Connick E, Bosch RJ, Aga E, Schlichtemeier R, Demeter LM, Volberding P. Augmented HIV-specific interferon-gamma responses, but impaired lymphoproliferation during interruption of antiretroviral treatment initiated in primary HIV infection. J Acquir Immune Defic Syndr. 2011 Sep 1; 58(1):1-8. 26. Volberding P. The impact of HIV research on health outcome and healthcare policy. Ann Oncol. 2011 Nov; 22 Suppl 7:vii50-vii53.

D. Research Support

Ongoing Research Support P30 AI027763 (Volberding) 9/1/12-8/31/17 NIH/NIAID UCSF-GIVI Center for AIDS Research Role: PI

The primary aim of this center grant is to nurture and sustain innovative multidisciplinary HIV research at the intersections of the basic, clinical, behavioral, and epidemiologic scientific disciplines.

UL1 RR024131 (Johnston) 7/1/11 – 6/30/16 NIH Clinical and Translational Science Institute Role: Global Health Program Director

To transform clinical and translational research to ensure that the best health solutions get to patients as quickly as possible. CTSI is a cross-campus institute whose goals are to enhance, support, and integrate existing infrastructure, training programs, implementing changes that promote research and education in clinical and translational science at UCSF, affiliated institutions, and in participating communities.

R13 AI102630 (Volberding) 9/1/12-8/31/17 NIH/NIAID Recent Advances in AIDS and HIV Research Role: PI

The primary aim of this conference grant is to provide funding for the annual Center for AIDS Research international symposium.

Completed Research Support P30 CA82103 (McCormick) 6/1/07-5/31/12 NIH Helen Diller Family Comprehensive Cancer Center Support Grant (Director’s Group) Role: Liaison Representing Veterans Administration

Within the senior leadership structure of the Cancer Center are leadership positions called "Liaisons". These leaders serve as liaisons either to geographic sites, constituencies or activities that are not otherwise well represented within our senior leadership roster. The liaisons interact with Bay Area hospitals, universities, medical centers, and UCSF departments to coordinate research efforts, share information, promote cooperation, and increase the Cancer Center’s value to the local community. The liaisons are members of the Cancer Center Executive Committee and participate in our quarterly leadership retreats.

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

NAME POSITION TITLE Whitmarsh, Ian Associate Professor of Anthropology eRA COMMONS USER NAME (credential, e.g., agency login) Iwhitmarsh EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University of California, Berkeley B.A. 5/98 Anthropology Princeton University Ph.D. 11/05 Anthropology University of North Carolina, Chapel Hill Postdoctoral 8/07 ELSI of Genetics Science, Technology, Massachusetts Institute of Technology Postdoctoral 8/08 and Society

A. Positions and Honors

Positions and Employment 2004-2005 Lecturer, Anthropology Department, Princeton University

2005-2007 Postdoctoral Fellow, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill

2007-2008 Postdoctoral Associate, Science, Technology and Society Department, Massachusetts Institute of Technology

2008-2012 Assistant Professor, Anthropology, History, and Social Medicine Department, University of California San Francisco

2012- Associate Professor, Anthropology, History, and Social Medicine Department, University of California San Francisco

B. Peer-reviewed Publications 1. Whitmarsh I, Davis A, Skinner D, and Bailey DB Jr. (2007). A place for genetic uncertainty: parents valuing an unknown in the meaning of disease. Social Science and Medicine (65): 1082-1093. 2. Whitmarsh I. (2008). Biomedical ambivalence: asthma diagnosis, the pharmaceutical, and other contradictions in Barbados. American Ethnologist, 35(1): 49-63 3. Bailey DB Jr, Skinner D, Davis AM, Whitmarsh I, Powell C. (2008). Ethical, legal, and social concerns about expanded newborn screening: fragile X syndrome as a prototype for emerging issues. Pediatrics 121(3):e693-704. Review. 4. Whitmarsh I. (2008). Biomedical ambiguity: race, asthma, and the contested meaning of genetic research in the Caribbean. Ithaca, NY: Cornell University Press. 5. Whitmarsh I. (2009). Hyperdiagnostics: postcolonial utopics of race-based biomedicine. Medical Anthropology 28(3): 285-315. 6. Whitmarsh I. (2009). Medical schismogenics: compliance and culture in Caribbean biomedicine. Anthropological Quarterly 82(2): 453-482. 7. Whitmarsh I, Jones DS, eds. (2010). What’s the use of race: modern governance and the biology of difference. Cambridge, MA: Massachusetts Institute of Technology 8. Whitmarsh I, Jones DS, eds. (2010). What’s the use of race: modern governance and the biology of difference. Cambridge, MA: Massachusetts Institute of Technology

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): 9. Whitmarsh, I. (2011) American Genomics in Barbados: Race, Illness, and Pleasure in the Science of Personalized Medicine. Body and Society 17:2 and 3: 159-182.

10. Whitmarsh, I. (2013) Troubling “Environments”: Postgenomics, Bajan Wheezing, and Levi-Strauss. Medical Anthropology Quarterly.

C. Research Support

Ongoing Research Support

Study Title: Perspectives on Diabetes Causes, Information, and Care among South Asian Americans Whitmarsh (PI) 7/2009- In-depth interviews among individuals participating in a UCSF medical study of the metabolic syndrome in South Asians (Metabolic Syndrome and Atherosclerosis in South Asians Living in America study (MASALA) (Principal Investigator: Alka Kanaya)) and South Asians in the Bay Area. The interviews explore the participant’s views of the causes, information, and treatments of diabetes, including they think of the medical information and care available to them, their views of the measures they have been advised to take, and what they think are the causes of diabetes in their families and larger community. This study contributes to understanding the ways communities with high levels of diabetes understand the condition and medical practice around it. Role: Principal Investigator

Study Title: Perspectives on Diabetes and Obesity in Trinidad and Tobago Whitmarsh (PI) 6/2008- The project uses in-depth interviews to explore how the relationship between heredity, obesity, diabetes, cholesterol, and heart disease is perceived in the Caribbean country of Trinidad and Tobago. The project further examines what patients think of medical care and information on their community. A second arm of the study explores the ways medical practitioners and researchers in Trinidad and Tobago view and act on the high rates of the metabolic syndrome among Trinidadians. Role: Principal Investigator

Completed Research Support

Study Title: Family Experiences of Turner, Klinefelter’s, and Triple X Diagnosis Whitmarsh (PI) 1/2006-1/2007 Interviews of families of children diagnosed with Turner’s and Klinefelter’s syndromes about receiving and utilizing genetic diagnoses. Open-ended in-depth interviews examined parent perspectives about the significance of the diagnosis for their family, their view of medical information and care based on the diagnosis, and the utility of genetic testing for the condition. The study was carried out as part of a Center for Excellence in ELSI Research (CEER) interdisciplinary team exploring the implications of expanded newborn screening. Findings were published in Social Science and Medicine and Pediatrics. Role: Prinicipal Investigator

Study Title: Significance of the Genetic of Asthma and Race Research in the Caribbean Whitmarsh (PI) 6/2002-9/2004 A long-term ethnographic study conducted in Barbados, researching the significance of a genetics of asthma study in the context of healthcare and pharmaceutical industry approaches in the Caribbean. Multiple in-depth interviews and participant-observation were carried out with interviewing genetics team, study facilitators, participants, pharmaceutical company representatives and distributors, members of the Ministry of Health, doctors, nurses, and pharmacists, and asthma outreach NGOs in Barbados. Findings were published in American Ethnologist, Medical Anthropology, Anthropological Quarterly and in a book, Biomedical Ambiguity: Race, Asthma, and the Contested Meaning of Genetic Research in the Caribbean, published by Cornell University Press in 2008. Role : Principal Investigator

PHS 398/2590 (Rev. 06/09) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Gavin Mark Yamey Lead, Evidence-to-Policy initiative, Global Health Group, University of California San Francisco

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Oxford University BA 06/90 Physiological Sciences University College London MB BS 06/94 Medicine Royal College of Physicians UK MRCP 06/97 Internal Medicine Oxford University MA (honorary) 06/07 Physiological Sciences London School of Hygiene & Tropical Medicine MSc. 09/10 Public Health

Principal Positions Held 2010-present Lead, Evidence-to-Policy Initiative (E2Pi), The Global Health Group, Global Health Sciences, University of California, San Francisco (UCSF); Course Director for Global Health Policy, Masters in Global Health, UCSF 2004-2010 Senior Editor, PLoS Medicine & Editorial Consultant, PLoS Neglected Tropical Diseases, Public Library of Science (PLoS) 2002-2004 Assistant Editor, BMJ (British Medical Journal) and Deputy Physician Editor, Best Treatments 2000-2002 Deputy Editor, wjm—Western Journal of Medicine (co-owned by BMJ Publishing Group and University of California) 1999-2000 Editorial Registrar (a fellowship in medical journalism and editing), BMJ 1994-1999 Clinical appointments (internal medicine, London, UK)

Other Positions Held 1994-1995 Whittington Hospital (University College London House Officer (HO) in General Medical School) and Chase Farm Hospital Medicine and General Surgery London 1995 Departments of Renal and Respiratory Medicine, Senior House Officer (SHO) in The Royal Postgraduate Hospital, Hammersmith, Medicine London 1996 The National Hospital for Neurology and SHO in Neurology Neurosurgery, London 1997 St Bartholomew's Hospital, London SHO in Medical Oncology 1997-98 Northwick Park, London SHO in General Medicine & Elderly Care 1998-99 The Mildmay Hospital, London SHO in HIV/AIDS Palliative Care 1999 Regional Neurological Rehabilitation Unit (RNRU), Registrar in Neurology the Homerton Hospital, London 2001 Tim Albert Training Course on Medical Editing For Assistant Tutor Editors from the Developing World, Barcelona Peer Review Congress 2002 The Open University, United Kingdom Honorary Consultant 2003 World Health Organization Temporary Adviser 2008 TDR (the WHO/World Bank/UNICEF/UNDP Temporary Adviser Special Programme for Research and Training in PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Tropical Diseases)

Honors and Awards 1990 Martin Wronker Prize for achievement at Oxford University (2nd highest degree in the University) 1990 St Anne's College Oxford Prize 1994 University College London Prizes for MB BS in Psychiatry, and Academic & Extracurricular Achievement 1994 University of London Prize in Pharmacology 2009 Kaiser Foundation Mini-Fellowship in Global Health Reporting 2011 Distinction for MSc degree in Public Health at London School of Hygiene and Tropical Medicine 2011 University of London 150th Anniversary Prize for MSc performance (this prize is awarded to students who, in completing their programs, achieved the highest set of marks for the whole degree)

Memberships 1993-1994 Medact (Medical Action for Global Security) 1994-1999 British Medical Association 2006-2008 Council of Science Editors

Service to Professional Organizations 2005-2007 Member of the Council of Science Editors Task Force on Journals, Poverty and Human Development (http://www.councilscienceeditors.org/services/taskforce.cfm) 2007-present “Small Journals Taskforce” of the World Association of Medical Editors 2008-present Equity Edit (charitable organization which helps to fund small, innovative, pro-poor global health organizations), Advisory Board 2008-present Global Health Corps, mentor to Global Health Corps Fellows (www.ghcorps.org) 2012-2013 Member of the Center for Global Development Working Group on Value for Money in Global Health 2012-present Commissioner, Commission on Investing in Health (www.globalhealth2035.org) 2013-present Commissioner, Commission on Global Surgery (http://www.globalsurgery.info/)

Service to Professional Publications 2009-present Editorial Board Member, Health and Human Rights: An International Journal (http://www.hhrjournal.org/index.php/hhr), edited by Professor Paul Farmer 2010-2013 Editorial Board Member, BMJ (http://bmj.com 2010-present Editorial Board Member, Scholarly and Research Communication (http://journals.sfu.ca/src/index.php/src/index) 2010-present Ad hoc referee for Annals of Internal Medicine, BMJ; the Biomed Central journals; Health Affairs; African Health Sciences; freelance editor at PLoS Medicine (approximately 1-2 papers per week)

Selected Peer-Reviewed Publications 1. Yamey, G. WHO in 2002: Have the latest reforms reversed WHO's decline? BMJ 2002;325:1107-1112. 2. Yamey G. WHO in 2002: WHO's management: struggling to transform a "fossilised bureaucracy." BMJ 2002; 325:1170-1173. 3. Yamey G . WHO in 2002: Faltering steps towards partnerships. BMJ 2002;325:1236 - 1240. 4. Yamey G. WHO in 2002: Why does the world still need WHO? BMJ 2002;325:1294 -1298. 5. Yamey G. WHO in 2002: Interview with Gro Brundtland. BMJ 2002;325:1355. 6. Yamey G, Greenwood R. Religious views of the 'medical' rehabilitation model: a pilot qualitative study. Disabil Rehabil. 2004 Apr 22;26(8):455-62. 7. Yamey G. Excluding the poor from accessing the biomedical literature: a rights violation that impedes global health. Health and Human Rights: An International Journal, North America, 10 7 05 2008. This PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): paper was selected for inclusion in Faculty of 1000 Medicine (http://f1000.com/), as an outstanding paper (rating: “6, recommended”); see http://f1000.com/4082956?key=z2p98jg1prcyyfp. 8. Schäferhoff M, Schrade C, Yamey G. Financing maternal and child health—what are the limitations in estimating donor flows and resource needs? PLoS Med 2010;7(7): e1000305. 9. Schäferhoff M, Yamey G. Estimating benchmarks of success in the Affordable Medicines Facility-malaria Phase 1. Peer reviewed by nine external peer reviewers and published by the Global Fund to Fight AIDS, Tuberculosis and Malaria (www.theglobalfund.org/documents/amfm/E2PI_EstimatingBenchmarksInAMFm_Report_en.pdf) 10. Montagu D, Yamey G, Visconti A, Harding A, Yoong J. Where do poor women give birth? A multi-country analysis of Demographic and Health survey data. PLoS ONE 2011 2011;6(2): e17155. 11. Yamey G. Scaling up global health interventions: a proposed framework for success. PLoS Med 2011; 8(6): e1001049. doi:10.1371/journal.pmed.1001049 12. Montagu D, Yamey G. Pay-for-performance and the Millennium Development Goals. Lancet 2011; 377:1383-1385 13. Yamey G, Feachem R. Evidence-based policymaking in global health—the payoffs and pitfalls. Evidence Based Medicine 2011;16(4):97-9. 14. Yamey G. What are the barriers to scaling up health interventions in low and middle income countries? A qualitative study of academic leaders in implementation science. Globalization and Health 2012;8:11 15. Yamey G, Schäferhoff M, Montagu D. Piloting the Affordable Medicines Facility-malaria (AMFm): what will success look like? Bulletin of the WHO 2012 90:452-460. 16. Cohen JM, Smith DL, Cotter C, Ward A, Yamey G, Sabot OJ, Moonen B. Malaria resurgence: a systematic review and assessment of its causes. Malaria Journal 2012; 24;11:122. 17. Rosinski AA, Narine S, Yamey G. Developing a scorecard to assess global progress in scaling up diarrhea control tools: a qualitative study of academic leaders and implementers. PLoS ONE 2013; 8(7):e67320 18. Singhrao R, Huchko M, Yamey G. Reproductive and maternal health in the post-2015 era: cervical cancer must be a priority. PLoS Med. 2013;10(8):e1001499. 19. Jamison DT, Summers LH, Alleyne G, Arrow KJ, Berkley S, Binagwaho A, Bustreo F, Evans D, Feachem RG, Frenk J, Ghosh G, Goldie SJ, Guo Y, Gupta S, Horton R, Kruk ME, Mahmoud A, Mohohlo LK, Ncube M, Pablos-Mendez A, Reddy KS, Saxenian H, Soucat A, Ulltveit-Moe KH, Yamey G. Global health 2035: a world converging within a generation. Lancet 2013; 82(9908):1898-955

Textbook

The Handbook of Global Health Policy, edited by Yamey G, Brown G, and Wamala S, published by Wiley- Blackwell in May 2014 in the UK and June 2014 in the US.

Research Support

Ongoing research support OPPGH4830/UCSF Award A113448 (Co-Investigator) 11/01/2009 - 10/31/2014 Bill & Melinda Gates Foundation $1,680,471direct/yr1 The goal of this project is to develop and synthesize evidence to inform $2,705,513 total global health policy and decision-making.

OPP1106213 / UCSF Award A123077 (PI) 03/01/2014 - 09/30/2014 Bill & Melinda Gates Foundation $295,454 direct/yr1 PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

Commission on Investing in Health (CIH) Phase 2: Leveraging the $295,454 total direct Convergence Indicators to Shape the Post - 2015 Development Goals

A123102 (PI) 03/17/2014 - 12/31/2014 Swedish Expert Group for Aid Studies $12,811 direct/yr1 Future Role of Swedish Health Aid $12,811 total direct

Completed research support

A120829 (PI) 10/01/2012 - 02/28/2014 Center for Disease Dynamics, Economics and Policy $21,794 directs/Yr 1 $302,945 (Prime funder: Bill & Melinda Gates Foundation) total direct Lancet Commission on "Investing in Health: World Bank World Development Report 1993 @ 20 Years"

A122550 (PI) 07/01/2013 - 11/30/2013 SEEK Development $12,072 direct/yr1 (Prime Funder: Global Fund to Fight AIDS, Tuberculosis and Malaria) $12,072 total direct Quantitative estimation of the Global Fund contribution to MDGs 4 & 5

P0054012 (PI) 03/19/2012 - 12/31/2012 SEEK Development $9,350 direct/yr1 Prime: World Health Organization/UNITAID $9,350 total direct 5-Year Evaluation of UNITAID

A119267 (PI) 02/06/2012 - 05/31/2012 Bill & Melinda Gates Foundation $153,655 direct/yr 1 Establishing Service Delivery Unit Cost Benchmarks to Inform Payment $153,655 total direct Rates by the Global Fund

A118651 (PI) 07/12/2011 - 09/30/2011 Contractor: SEEK Development $79,164 direct/yr1 Prime: WHO/Partnership for Maternal, Newborn and Child Health $79,164 total direct Options for Improving Maternal, Newborn and Child Health through Strengthening the Global Aid Architecture

A116241 (PI) 11/01/2010 - 08/31/2011 Clinton Health Access Initiative $276,875 direct/yr1 Prime Securing Sustained Financing for Successful Malaria Control: $276,875 total direct Building the Evidence Base and Supporting Practical Country Solutions

A115807 (PI) 05/26/2010 - 12/31/2010 Global Fund to Fight AIDS, Tuberculosis & Malaria $51,903 direct/yr1 Review of experience to identify how to assess success of AMFm Phase 1 $51,903 total direct

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

N/A (Investigator) 01/01/2009 - 12/31/2009 Kaiser Family Foundation $8,000 total Funding to investigate large scale implementation of evidence-based tools in East Africa: Sudan, Kenya, Uganda (investigative journalism fellowship)

39544 (PI) 03/02/2006 - 03/01/2010 Bill & Melinda Gates Foundation $1,092,194 total Grant to launch PLoS Neglected Tropical Diseases "http://www.plos.ntds.org" www.plos.ntds.org

PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Lydia B. Zablotska Associate Professor (In Residence series) eRA COMMONS USER NAME ZABLOTSKAL EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE MM/YY FIELD OF STUDY (if applicable) Minsk State Medical School, Belarus M.D. 06/93 Medicine Lviv State Medical School, Ukraine 07/95 Residency in Internal Medicine Askew School of Public Administration, Florida M.P.A. 08/97 Public Policy and Health State University, Tallahassee, FL Administration Mailman School of Public Health, Columbia Ph.D. 05/03 Epidemiology University, New York, NY

A. Personal Statement My research activities have focused primarily on the study of the effects of radiation exposures in various settings, and on nutritional epidemiology, particularly as it relates to cancer risk. Throughout my career I conducted a number of epidemiological studies in many countries around the world, including Ukraine, Belarus, Bangladesh and Canada. For many years I was the principal investigator of the NCI-funded contract which provided scientific support for three studies of the consequences of the Chernobyl accident in Ukraine. Two cohort studies of thyroid cancer and other thyroid diseases were conducted among more than 25,000 exposed as young people to fallout from the accident in Ukraine and Belarus. The main focus of the studies was on the relationship between exposure to radioactive iodines and an increased risk of thyroid cancer and other thyroid diseases. The third study was a case-control study of leukemia in Chornobyl clean-up workers from Ukraine. Working with US and Ukrainian and Belarusian investigators, we maintained high study retention rates and provided great quality of care for patients in both countries.

Over the last 12 years I investigated the effects of radiation in a number of occupationally exposed cohorts in Canada, including nuclear workers, uranium miners and uranium processors. In addition, in recent years I worked with the cohort of 64,000 Canadian tuberculosis patients exposed to repeated chest fluoroscopies in the 1930s and 1940s. Most recently, I collaborated on an EPA-funded cohort study investigating carcinogenic effects of arsenic exposure among 12,000 adults in Bangladesh, analyzing the modifying effects of nutrition on the association between exposure to water arsenic and skin lesions.

In addition to my research activities, I have extensive experience in teaching Epidemiology to various levels of learners. Past courses include a large introductory course in epidemiology to Master’s level students at Columbia University, advanced research methods courses and seminars for doctoral students in the Department of Epidemiology and Biostatistics at UCSF and at the School of Nursing at UCSF, as well as smaller seminar-style courses in environmental and occupational epidemiology, cancer and pharmacoepidemiology. I am the author of Epiville, an open-access website featuring a set of interactive modules providing training in main epidemiological principles (http://www. ccnmtl.columbia.edu/projects/epiville/). Since its creation in 2000, the website has been used extensively by national and international academic educators as well as by public health practitioners from around the world.

B. Positions and Honors Positions and Employment 1993-1995 Residency in Internal Medicine, Chief Resident, Lviv State Medical School, Ukraine 2000-2003 Staff Associate, Department of Epidemiology, Mailman School of Public Health (MSPH), Columbia University, New York, NY 2003-2004 Instructor, Department of Epidemiology, MSPH, Columbia University, New York, NY 2004-2008 Assistant Professor, Department of Epidemiology, MSPH, Columbia University, New York, NY 2008-2010 Assistant Professor, Department of Epidemiology and Biostatistics (DEB), School of Medicine (SOM), University of California, San Francisco (UCSF), San Francisco, CA 2010-2012 Associate Professor, DEB, SOM, UCSF, San Francisco, CA 2012- Associate Professor, In Residence series, DEB, SOM, UCSF, San Francisco, CA 2013- Head, Occupational and Environmental Area of Concentration, DEB, SOM, UCSF, San Francisco, CA

Other Experiences and Professional Memberships 1997- Member, American Public Health Association 2003- Member, Radiation Research Society 2004- Member, American Society of Preventive Oncology 2004- Member, Society for Epidemiologic Research 2004-2006 Member, Advisory Council on Chronic Lymphocytic Leukemia Radiogenicity Research, National Institute for Occupational Safety and Health 2005-2007 Adviser, Committee on Reconsideration of Exclusion of Chronic Lymphocytic Leukemia from Eligibility for Compensation under EEO/CPA, National Institute for Occupational Safety and Health 2006- Member, American Statistical Association 2006-2011 Consultant, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), Report on the Health Effects Due to Radiation from the Chernobyl accident, Sections on Leukemia and Cancer Registries 2012- Member, NIH Special Emphasis Study Section ZRG1 PSE-Q (02) M 2012- Member, NIH Peer Review Committee ZCA1 SRLB-3 M2 Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts

Honors 1993 Graduation with Distinction (Summa Cum Laude), Minsk State Medical School, Minsk, Belarus 1995 Senator E. Muskie Scholarship for Graduate Studies for Outstanding Students from the Commonwealth of Independent States, U.S. Agency for International Development 2003 Sydney Kark Award in Epidemiology for doctoral student committed to work in international health, MSPH, Columbia University, New York, NY 2003 Young Investigator Award, 12th International Congress of Radiation Research, Brisbane, Australia 2004 Calderone Junior Faculty Research Prize, MSPH, Columbia University, New York, NY 2005 Dean’s Award for Innovation in the Curriculum, MSPH, Columbia University, New York, NY 2006 New Investigator Award, American Statistical Association’s Conference on Radiation and Health, Monterey Beach, CA 2007 Young Investigator Award, 13th International Congress of Radiation Research, San Francisco, CA 2007 Invited Participant, Centers for Disease Control and Prevention (CDC) Workshop on Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Etiologic Factors, Precursors, and Disease, Washington, DC 2008 Invited Speaker, 17th International Conference on Health and Environment: Global Partners for Global Solutions, United Nations Headquarters, New York, NY 2008 Invited Speaker, Low-Dose Radiation Epidemiology Workshop, Department of Energy, Washington, DC 2010 Invited Speaker, 43rd annual meeting of the Society for Epidemiologic Research, Seattle, WA 2011 Certificate of Appreciation for 'Valued Authors,' American Journal of Epidemiology 2012 Symposium Chair, Invited Speaker, 58th annual meeting of the Radiation Research Society, San Juan, Puerto Rico 2012 Keynote Speaker, International Symposium for 50th Anniversary of RIRBM, Hiroshima University, “Support for Restoration from Fukushima Daiichi Nuclear Disaster,” Hiroshima, Japan 2012 Session Chair, Invited Speaker, American Statistical Association’s Conference on Radiation and Health, Kennebunkport, ME 2013 Keynote Speaker, 11th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2013), Berkeley, CA 2014 Symposium Chair, Invited Speaker, 47th annual meeting of the Society for Epidemiologic Research, Seattle, WA 2014 Member of the Organizing Committee, Chair of the Workshop for Early Stage Radiation Investigators (ESRI), Invited Speaker, joint meeting of the Radiation Research Society and Conference on Radiation and Health, Las Vegas, NV

C. Selected Peer-reviewed Publications (in chronological order, selected from 54).

1. Zablotska LB, Neugut AI. Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma. Cancer. 2003;97(6):1404-11. PMID: 12627503. 2. Zablotska LB, Bogdanova TI, Ron E, Epstein OV, Robbins J, Likhtarev IA, et al. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: Dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000). Am J Epidemiol. 2008;167(3):305-12. PMID: 17989057. 3. Lane RS, Frost SE, Howe GR, Zablotska LB. Mortality (1950-1999) and cancer incidence (1969-1999) in the cohort of Eldorado uranium workers. Radiat Res. 2010;174(6):773-85. PMID: 21128801. 4. Zablotska LB, Ron E, Rozhko AV, Hatch M, Polyanskaya ON, Brenner AV, et al. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br J Cancer. 2011;104(1):181-7. PMCID: PMC3039791. 5. Zablotska LB, Bazyka D, Lubin JH, Gudzenko N, Little MP, Hatch M, et al. Radiation and the Risk of Chronic Lymphocytic and Other Leukemias among Chornobyl Cleanup Workers. Environ Health Perspect. 2013 Jan;121(1):59-65. PMID: 23149165. 6. Zablotska LB, Lane RSD, Frost SE. Mortality (1950–1999) and cancer incidence (1969–1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses. BMJ Open 2013 Feb 27;3(2): e002159. PMID: 23449746. 7. Zablotska LB, Lane RSD, Thompson P. A reanalysis of cancer mortality in Canadian nuclear workers (1957 –1994) based on revised exposure and cohort data. Br J Cancer. 2014;110(1):214-23.PMID: 24231946. 8. Zablotska LB, Little MP, Cornett RJ. Potential Increased Risk of Ischemic Heart Disease Mortality With Significant Dose Fractionation in the Canadian Fluoroscopy Cohort Study. Am J Epidemiol. 2014 Jan 1;179(1):120-31. PMID: 24145888. 9. Zablotska LB, Lane RSD, Frost SE, Thompson P. Leukemia, lymphoma and multiple myeloma mortality (1950-1999) and incidence (1969-1999) of in the Eldorado uranium workers cohort. Environmental Research. 2014 Apr;130:43-50. PMID: 24583244. 10. Zablotska LB, Nadyrov E, Hatch M, Brenner A, McConnell R, O'Kane P, et al. Analysis of thyroid malignant pathological findings identified during three rounds of screening (1997-2008) of a Belarusian cohort of children and adolescents exposed to radioiodines after the Chernobyl accident. Cancer 2014. doi: 10.1161/CANCER.113.000799.

D. Research Support Ongoing Research Support K07CA132918 Zablotska (PI) 08/01/14 - 07/31/15 Risk of leukemia after protracted exposures to low doses of ionizing radiation No cost extension with funds for research only (no salary support). Role: PI

69922-565244 Zablotska (PI) 02/01/13 - 07/01/14 UCSF Strategic Opportunities Support (SOS) Program, Multidisciplinary Research Project Planning Award Meeting of international collaborators to extend studies of radiation-related hematologic malignancies among cleanup workers of the Chornobyl nuclear accident. This project is intended to fund an international conference of collaborators to develop plans to apply for a R03 grant to conduct a pooled analysis of leukemia and multiple myeloma among Chornobyl cleanup workers from Ukraine, Belarus, Russia and Baltic countries and for an R01 grant to extend and expand the follow-up of this cohort from 20 to 30 years. Role: PI

87055-13-0577 Zablotska (PI) 08/01/14 - 07/31/15 Canadian Nuclear Safety Commission

Mortality risks in the pooled analysis of the Canadian and German uranium workers. The data from the study of Eldorado uranium workers from Canada and from the Wismut study of uranium miners from Germany will be pooled to analyze mortality risks from exposures to radon decay products and whole-body gamma radiation with special emphasis on radiation risks of cardiovascular diseases. Role: PI

Completed Research Support K07CA132918 Zablotska (PI) 08/09/10 - 08/08/14 NIH/NCI Risk of Leukemia after Protracted Exposures to Low Doses of Ionizing Radiation This Academic Career Development Award provided funding for salary support and continued training in the area of genetic and cancer epidemiology. Additional funds were provided to conduct a study examining the association between exposures to low doses of ionizing radiation and risk of leukemia in Chornobyl cleanup workers from Ukraine and to assess the role of environmental and genetic factors in carcinogenesis from a new multidisciplinary perspective. Role: PI

R20121220 Zablotska (PI) 02/01/08 - 01/31/14 Canadian Nuclear Safety Commission Analysis of cancer incidence and mortality of uranium and radium processing workers from Port Hope. The funding provided support for organizing a cohort of workers from the Port Hope uranium and radium processing facility in Canada from employment records. Risk analyses were conducted by linking the cohort with the Canadian Mortality (1950-1999) and Incidence (1969-1999) Databases. Role: PI

N01-CP-21178 Zablotska (PI) 10/01/06 - 08/08/10 NHI/NCI Health effects of the Chernobyl accident on the incidence of thyroid cancer and leukemia. This contract project consisted of two large cohort studies of thyroid cancer and other thyroid diseases in those exposed to Chornobyl fallout as children in Ukraine and Belarus. The third study was a case-control study of leukemia in clean-up workers in Ukraine. The contract was continuously funded by NCI since 10/01/1997. Dr. Zablotsks became a PI on 10/01/2006. Role: PI n/a Kubale (PI) 11/01/08 - 07/01/10 NIOSH Nested case-control study of leukemia mortality among nuclear power industry and DOE facilities workers occupationally exposed to ionizing radiation. The project examined the characteristics of workers from the cohort study of U.S. nuclear power industry workers and the possibility of pooling the data from this study with the data for workers from DOE nuclear facilities to examine risks of leukemia in this cohort due to occupational radiation exposures. Role: Sub-contract PI n/a Zablotska (PI) 01/01/07 - 08/31/08 Canadian Nuclear Safety Commission Analysis of Cancer Mortality Among Employees of the Atomic Energy of Canada Limited (AECL) Following Occupational Radiation Exposures. This project compared dose records for AECL employees with doses contained in the National Dose Registry of Canada and provided radiation risk estimates in this group based on revised exposure and cohort data. Role: PI

Principal Investigator/Program Director (Last, First, Middle):

Principal Investigator/Program Director Ziegler, John L.

(Last First ) BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

NAME POSITION TITLE John L. Ziegler, MD MSc. Professor in Residence Emeritus, Department of Medicine, UCSF

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as

DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Amherst College, Amherst MA BA 1956-1960 English Literature Cornell University Medical College, New York NY MD 1960-1964 Medicine London School of Hygiene and Tropical Medicine M Sc 1996-1997 Epidemiology

Positions and Employment 1964-66 Medical Resident, Second (Cornell) Medical Division, Bellevue Hospital and Memorial Hospital-Sloan Kettering Cancer Center, New York, NY 1966-67 Clinical Associate, Medicine Branch, National Cancer Institute 1967-72 Founding Director, Uganda Cancer Institute, Makerere University Medical School, Kampala, Uganda; Senior Investigator, Medicine Branch, National Cancer Institute 1967-72 Honorary Lecturer in Medicine, Makerere University Medical School, and Honorary Senior Registrar, Mulago Hospital, Kampala, Uganda; Lecturer in Surgery, Harvard College; Clinical Associate Professor, Cornell University Medical College 1972-75 Chief, Pediatric Oncology Branch, Division of Cancer Treatment, NCI 1975-80 Deputy Clinical Director, National Cancer Institute and Associate Director, Clinical Oncology Program, Division of Cancer Treatment, NCI 1980-81 Editor-in-Chief, Journal of the National Cancer Institute, National Cancer Institute 1981-96 Associate Chief of Staff for Education and Staff Physician, Veterans Affairs Medical Center, San Francisco, California; Professor of Medicine in Residence, School of Medicine, University of California San Francisco 1994-96 Senior Scientist (on detail from Department of Veterans Affairs in collaboration with US Centers for Disease Control), International Agency for Research on Cancer, World Health Organization, Lyon, France. On assignment to Makerere University, Kampala, Uganda. 1976-78 Associate Clinical Professor of Medicine, George Washington University Medical School, Washington DC

Principal Investigator/Program Director (Last, First, Middle): Ziegler, John L.

1979-81 Associate Clinical Professor of Medicine, Georgetown University School of Medicine, Washington, D.C. 1980-81 Professor of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 1990-91 Visiting Fulbright Professor of Medicine, Makerere University Medical School, Kampala, Uganda (on sabbatical leave from UCSF) 1992-93 Visiting Professor, University of Cambridge and Associate, Darwin College 1992-96 Visiting Professor, London School of Hygiene and Tropical Medicine 1994-96 Visiting Fulbright Professor of Medicine, Makerere University Medical School, Kampala, Uganda 1995-2000 Visiting Scientist, ICRF Cancer Epidemiology Unit, Oxford University 1996- Professor in Residence Emeritus, School of Medicine, University of California, San Francisco 1998-2007 Director, Cancer Risk Program, UCSF Comprehensive Cancer Center 2007-13 Director, Masters Degree Program, UCSF Global Health Sciences

Honors and Awards (Selected): 1969 United States Public Health Service Commendation Medal 1972 Albert and Mary Lasker Award 1973 American Society of Clinical Investigation 1983 Heath Award, M.D. Anderson Hospital 1990-91 Fulbright Research Scholar, Makerere University, Kampala, Uganda 1991 Howard Gilman Foundation Honors Program Lecturer, NY University 1992 Associate, Darwin College, University of Cambridge 1994-95 Fulbright Research Scholar, Makerere University, Kampala, Uganda 2002 Paul P.Carbone Memorial Award in International Oncology, INCTR, Brussels

Publications (selected for global health from a total of 250) 1. Ziegler JL, Katongole-Mbidde E. Childhood Kaposi's sarcoma in Uganda. Analysis of 100 cases and relationship to HIV infection. Int J Cancer 65:200-203;1996 2. Ziegler JL, Katongole-Mbidde E. Diminished delayed hypersensitivity in the legs and feet of patients with endemic Kaposi's sarcoma. J Roy Soc Trop Med & Hyg. 90:173-4;1996. 3. Chang Y. Ziegler JL, Wabinga H. et al. Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Arch Int Med 156:202-204;1996 4. Gao S. Kingsley L, Zheng W, Parravicini M, Ziegler JL, Newton R. et al. KSHV antibodies among Americans, Italians, and Ugandans with and without Kaposi's sarcoma. Nature Med 2:925928; 1996 5. Participant, IARC Monograph on the Evaluation of Carcinogenic Risks to Humans. Vol 67: Human Immunodeficiency Virus and Human T-cell Lymphotropic Virus. IARC, 1997 6. Ziegler, JL. Editorial. Geophagy: a vestige of paleonutrition. Tropical Medicine and International Health 2:609-611;1997 7. Ziegler JL, Newton R. Katongole-Mbidde E, et al. Risk factors for Kaposi's sarcoma in HIV positive subjects in Uganda. AIDS 11:1619-26; 1997 8. Parkin DM and Ziegler JL: Malignant Diseases. In Strickland, G.T., (ed). Hunter's Tropical Medicine, 8th edition. WB Saunders, Philadelphia, 1997, 96-106 9. Rutakingira M, Ziegler JL, Newton R. Freers J. Poverty and eosinophilia are risk factors for endomyocardial fibrosis in Uganda. Trop Med Int Health 4:229-235; 1999

Principal Investigator/Program Director (Last, First, Middle): Ziegler, John L.

10. Parkin DM, Garcia-Gianoli H, Newton R, Raphael M, Martin A, Katongole-Mbidde E, Ziegler J, et al.. Non Hodgkin lymphomas in Uganda. A case control study. AIDS 14:2929-36;2000 11. International HIV Collaborative Group. The impact of highly active anti-retroviral therapyon the incidence of cancer in people infected with the human immunodeficiency virus. Collaborative re-analysis of individual data. JNCI 92:1823-30;2000 12. Newton R, Ziegler JL, Beral, V, et al. A case control study of HHV8 infection in adults and children in Uganda. Int J. Cancer 92:622-7, 2001 13. Ziegler JL, Simonart T, Snoeck R. Kaposi’s Sarcoma, Oncogenic Viruses, and Iron. J Clin Virology 20:127-30;2001 14. Ziegler JL. Into and out of Africa. Taking over from Denis Burkitt. Brit J Haematol 2012 156:766-9 15. Mbulaiteye S, Ziegler JL, Katangole-Mbidde E. Cancers and lymphomas. In: Mabey DMW, Gill GV, Parry EHO, Weber MW, Whitty CJM eds. Principals of Medicine in Africa. Fourth Edition, Cambridge University Press (2012) 16. Newton R, Sitas F, Dedicoat M, Ziegler JL. Human immunodeficiency virus infection and cancer in Africa. In: Essex M, ed. AIDS in Africa (2002) 17. Newton R, Ziegler JL, Attenyi-Agaba C, et al. The epidemiology of conjunctival squamous cell carcinoma in Uganda. Brit J Cancer 2003;88;2002-3 18. Newton R , Ziegler JL, Bourbillia D, et al. The sero-epidemiology of Kaposi’s sarcoma- associated herpesvirus (KSHV/HHV-8) in adults with cancer in Uganda. Int J Camcer 2003;103:226-32 19. Ziegler J, Newton R, Bourbillia D et al. Risk factors for Kaposi’s sarcoma: a case control study of HIV –seronegative people in Uganda. Int J Cancer 2003;103:233-40 20. Bukhman G, Ziegler J, Parry EHO. Endomyocardial fibrosis. Still a mystery after 60 years. Plos Negl Trop Dis 2006; 2:e97 21. Ziegler J, Bounoguro F. Infectious agents and malignancy. Front Biosci. 2009;14: 3455-64 22. Ziegler JL. Hyperreactive malarial splenomegaly. Am J Trop Med Hyg. 2008;78:186-7

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Zimmer, Zachary Professor, Department of Social and Behavioral eRA COMMONS USER NAME (credential, e.g., agency Science, University of California San Francisco login) zzimmer EDUCATION/TRAININGzzimmer (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION (if MM/YY FIELD OF STUDY applicable)

University of Winnipeg B.A. 06/83 Sociology/ Criminology

University of Manitoba M.A. 06/89 Sociology/ International Development

University of Michigan Ph.D. 08/98 Sociology/ Demography

A. Personal Statement The goals of the proposed research involve examining the impacts of war exposure on health among the older population in Vietnam. Much of my career has revolved around studying issues related to older adult health in developing countries. My work in this field has been supported by several NIH grants on which I have served as PI, including “Comparative Study of Health Transitions in Later Life (R01)”, “Urban/Rural Disparities in Health and Mortality in China (R03),” and “Modeling Disability Trajectories in Rapidly Aging Populations (R21). Recent research that has been supported by UNFPA Cambodia and the Doha International Institute of Family Studies and Development, has examined aging issues in Cambodia. I led the 2004 Cambodian Elderly Survey, the first probability sample survey of older adults in that country. Using these data, I conducted some analyses on the impact of the Cambodian civil war in the late 1970’s on current support of older adults (published in Population and Development Review). The current project provides for a natural extension of my earlier research, with its focus on health and well-being of older adults in a country that lies in region within which I have done a great deal of work. The topic combines my expertise in older adult health in the region with a parallel focus on the impact of social change on elderly, particularly as it pertains to family relations. The project also fits well with a more recent focus I have on the impact of war and conflict on older adults in developing regions.

B. Positions and Honors 1992-1993: Research Associate, Centre on Aging, University of Victoria 1998-2000: Assistant Professor, Department of Sociology, University of Nevada-Las Vegas 2000-2006: Associate, Policy Research Division, Population Council, New York, USA 2006-2011: Professor, Department of Sociology, University of Utah 2006-2011: Senior Scholar, Institute of Public and International Affairs, University of Utah 2011- : Professor, Department of Social and Behavioral Sciences, UCSF 2011 : Superior Senior Researcher Award, University of Utah 2012 : PK Whelpton Memorial Lecture, Scripps Gerontology Center 2014 : UCSF Distinction in Teaching Award (nominee)

NIH review panels: ZAG1 ZIJ-1 (J1) Special Assignment Review Panel 10/03/11 ZRG1 PSE-K (02) Special Emphasis Panel/Scientific Review Group 1/24/2011 ZRG1 PSE-C (80) Social Science and Population Studies R03s, R15s, and R21s 2/26/10 ZRG1 HOP-B (90) Social Science and Population Studies R03s, R15s, and R21s 2/13/09 ZRG1 HOP-B (90) Social Science and Population Studies R03s, R15s, and R21s 6/15/07 ZRG1 HOP-B (90) Social Science and Population Studies R03s, R15s, and R21s 10/27/06 RG1 HOP-B (90) Social Science and Population Studies R03s, R15s, and R21s 2/24/06

C. Selected Peer-reviewed Publications (Selected from 70 peer-reviewed publications)

Recent publications most relevant to the current application

1. Zachary Zimmer and Vipan Prachuabmoh. 2012. Comparing the socioeconomic status – health gradient among adults 50 and older across rural and urban areas of Thailand in 1994 and 2007. Social Science and Medicine. 74(12): 1921-1928. 2. Zachary Zimmer, Kim Korinek, John Knodel and Napaporn Chayovan. 2008. Migrant interactions with elderly parents in rural Cambodia and Thailand. Journal of Marriage and the Family. 70(4): 585-598. 3. Zachary Zimmer. 2008. Poverty, wealth inequality and health among older adults in rural Cambodia. Social Science and Medicine. 66(1): 57-71. (PMCID: PMC2171035). 4. John Knodel, Zachary Zimmer, Kiry Sovan Kim and Sina Puch. 2007. The effect on elderly parents in Cambodia of losing an adult child to AIDS. Population and Development Review. 33(3): 479-500. 5. Zachary Zimmer, John Knodel, Kiry Sovan Kim and Sina Puch. 2006. The impact of past conflicts and social disruption in Cambodia on the current generation of older adults. Population and Development Review. 32(2): 333-360. (Revised version published in Susan McDaniel (ed.). 2008. Ageing. Thousand Oaks CA: Sage Publications.)

Additional recent publications of importance to the field (in chronological order)

6. Zachary Zimmer, Linda G. Martin, Bobby L. Jones and Daniel S. Nagin. 2014. Examining late-life functional limitation trajectories and their associations with underlying onset, recovery, and mortality. Journal of Gerontology: Social Sciences. 69(2): 275-286. doi:10.1093/geronb/gbt099. 7. Zachary Zimmer, Linda G. Martin, Daniel S. Nagin and Bobby L. Jones. 2012. Modeling disability trajectories and mortality of the oldest old in China. Demography. 49(1): 291-314. 8. Zachary Zimmer and Kim Korinek. 2010. Shifting coresidence near the end of life: Comparing decedents and survivors of a follow-up study in China. Demography. 47(3): 537-554. 9. Zachary Zimmer, Ming Wen and Toshiko Kaneda. 2010. A multi-level analysis of urban/rural and socioeconomic differences in functional health status transition among older Chinese. Social Science and Medicine. 71(3): 559-567. (PMCID: PMC2904335). 10. Zachary Zimmer, Toshiko Kaneda, Zhe Tang and Xianghua Fang. 2010. Explaining late life urban vs. rural health discrepancies in Beijing. Social Forces. 88(4): 1885:1908. (PMCID: PMC2998765) 11. Zachary Zimmer. 2009. Household composition among elders in Sub-Saharan Africa in the context of HIV/AIDS. Journal of Marriage and the Family. 71(4): 1086-1099. 12. Zachary Zimmer, Toshiko Kaneda and Laura Spess. 2007. An examination of urban versus rural mortality in China using community and individual level data. Journal of Gerontology: Social Sciences. 62(5): 349-357. 13. Zachary Zimmer, Linda G. Martin, Mary Beth Ofstedal and Yi-Li Chuang. 2007. Education of adult children and mortality of their elderly parents in Taiwan. Demography. 44(2): 289-305. 14. Zachary Zimmer. 2005. Health and living arrangement transitions among China’s oldest-old. Research on Aging. 27(5): 526-555 (Revised version published in Yi Zeng, Dudley Poston, Denese Ashbaught Vlosky and Danan Gu (eds.). 2008. Healthy Longevity in China: Demographic, Socioeconomic, and Psychological Dimensions. Dordrecht: Springer.) 15. Zachary Zimmer and Julia Kwong. 2003. Family size and support of older adults in urban and rural China: Current effects and future implications. Demography. 40(1): 23-44. D. Research Support

Ongoing Research Support

1R21 AG036938-01 Zimmer (PI) 04/01/10-03/31/13 NIH/NIH Modeling Disability Trajectories in Rapidly Aging Populations Disability of older adults is a major public health concern that affects both individual quality of life and societal costs of providing health care and other services. Yet studies that examine the disability experiences that individuals have over a number of years are rare in developed countries and virtually non-existent in developing countries, which are also experiencing rapid increases in their older populations. This project identifies the types of disability changes that are typical as people age in Taiwan and Mainland China, as well as characteristics of individuals who have more versus less favorable experiences.

Other Recently Completed Research Support

Doha International Institute for Family Studies & Development (PI) 01/01/10-12/31/12 The Impact of Migration on the Family and Intergenerational Solidarity The purpose of the project is to conduct research on the economic and social impacts of migration in Cambodia on older people left behind in rural villages. The movement of people from rural areas in developing countries to cities and across borders, primarily in search of employment, is an inescapable consequence of development and the globalization process occurring throughout the world. This type of labor migration has become persistent and an accelerating reality in many developing countries. How this impacts on intergenerational family solidarity remains, however, a matter of considerable debate. This effort, which is a small scale pilot-type study, provides initial systematic empirical evidence that aims to expose some of the effects for the older generation in Cambodia.

University of Utah, Center on Aging Zimmer (PI) 01/01/11-12/31/11 The Impact of Migration of Adult Children on the Well-Being of Older Parents in Romania This is an internal seed grant meant to facilitate preliminary research on the subject of the effect of migration on older people living in Romania.

United Nations Population Fund (PI & UN Consultant) 06/15/11-08/31/12 Rural/Urban Migration in Cambodia The multiple aims of this project include first consulting on three data collection efforts in Cambodia: (1) recent migrants to the city of Phnom Penh; (2) households in rural areas with and without recent migrants; (3) rural village leaders. Next, there will be analysis of these datasets with the aim of developing a policy report on rural/urban migration in Cambodia. Finally, there is a capacity development component involving working directly with and training researchers at the Ministry of Planning in Cambodia.

R03 AG025729 Zimmer (PI) 05/01/07-04/30/10 NIH/NIA Urban/Rural Disparities in Health and Mortality in China The main aims of this project involve describing discrepancies in functional health and mortality across samples of older adults living in rural and urban areas of China and examining the extent to which these can be explained with reference to a combination of individual and community-level characteristics. Three secondary data sources are employed: The China Health and Nutrition Survey, The Sampling Survey on the Status of the Elderly in Urban and Rural China and The Beijing Multidimensional Longitudinal Study of Aging. Urban/rural discrepancies in health are explored using a variety of methodological techniques, including nested multivariate and multilevel models that combine and interact individual and community characteristics.