Population Genomics in a Disease Targeted Primary Cell Model
Downloaded from genome.cshlp.org on October 8, 2021 - Published by Cold Spring Harbor Laboratory Press Letter Population genomics in a disease targeted primary cell model Elin Grundberg,1,2,12 Tony Kwan,1,2,12 Bing Ge,2 Kevin C.L. Lam,2 Vonda Koka,2 Andreas Kindmark,3 Hans Mallmin,4 Joana Dias,2 Dominique J. Verlaan,1,2,5 Manon Ouimet,5 Daniel Sinnett,5,6 Fernando Rivadeneira,7,8 Karol Estrada,7 Albert Hofman,8 Joyce M. van Meurs,7 Andre´ Uitterlinden,7,8 Patrick Beaulieu,5 Alexandru Graziani,5 Eef Harmsen,2 O¨ sten Ljunggren,3 Claes Ohlsson,9 Dan Mellstro¨m,9 Magnus K. Karlsson,10 Olle Nilsson,4 and Tomi Pastinen1,2,11,13 1Department of Human Genetics, McGill University, Montre´al H3A 1B1, Canada; 2McGill University and Genome Que´bec Innovation Centre, Montre´al H3A 1A4, Canada; 3Department of Medical Sciences, Uppsala University, Uppsala 75185, Sweden; 4Department of Surgical Sciences, Uppsala University, Uppsala 75185, Sweden; 5Sainte-Justine University Health Center, Montre´al H3T 1C5, Canada; 6Department of Pediatrics, University of Montre´al, Montre´al H3T 1C5, Canada; 7Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, The Netherlands; 8Department of Epidemiology, Erasmus MC, Rotterdam 3015GE, The Netherlands; 9Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Go¨teborg University, Gothenburg 41345, Sweden; 10Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Science, Lund University and Department of Orthopaedics, Malmo¨University Hospital, Malmo¨20502, Sweden; 11Department of Medical Genetics, McGill University, Montre´al H3H 1P3, Canada The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regu- lation in a cell type-specific manner.
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