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Preclinical Research 2020 Sections Sackler Faculty of Medicine Preclinical Research 2020 Sections Cancer and Molecular Therapies 8 Dental Health and Medicine 52 Diabetes, Metabolic and Endocrine Diseases 62 Genomics & Personalized Medicine 78 Hearing, Language & Speech Sciences and Disorders 98 Infectious Diseases 117 Inflammatory and Autoimmune Diseases 137 Medical Education and Ethics 147 Nervous System and Brain Disorders 154 Nursing, Occupational and Physical Therapy 200 Public Health 235 Reproduction, Development and Evolution 263 Stem Cells and Regenerative Medicine 280 Cover images (from bottom left, clockwise): Image 1: Human embryonic stem cell derived cardiomyocytes stained with fluorescent antibodies. The cardiac marker alpha-actinin (green), calcium channel modulator, Ahnak1 (red) – Shimrit Oz, Nathan Dascal. Image 2: Islet of Langerhans containing insulin-producing beta-cells (green) and glucagon- producing alpha-cells (red) – Daria Baer, Limor Landsman. Image 3: β-catenin in C. elegans vulva – Michal Caspi, Limor Broday, Rina Rosin-Arbesfeld. Image 4: Stereocilia of a sensory outer hair cell from a mouse inner ear – Shaked Shivatzki, Karen Avraham. Image 5: Electron scanning micrograph of middle ear ossicles from a mouse ear stained with pseudo colors – Shaked Shivatski, Karen Avraham. Image 6: Resistin-like molecule alpha (red), eosinophil major basic protein (green) and DAPI (blue) staining of asthmatic mice – Danielle Karo-Atar, Ariel Munitz. © All rights reserved Editor: Prof. Karen Avraham Graphic design: Michal Semo Kovetz, TAU Graphic Design Studio February 2020 Sackler Faculty of Medicine Research 2020 2 The Sackler Faculty of Medicine The Sackler Faculty of Medicine is Israel’s largest diabetes, neurodegenerative diseases, infectious medical research and training complex. The Sackler diseases and genetic diseases, including but not Faculty of Medicine of Tel Aviv University (TAU) was imited to Alzheimer’s disease, Parkinson’s disease founded in 1964 following the generous contributions and HIV/AIDS. Physicians in 181 Sacker affiliated of renowned U.S. doctors and philanthropists departments and institutes in 17 hospitals hold Raymond, and the late Mortimer and Arthur Sackler. academic appointments at TAU. The Gitter-Smolarz Research at the Sackler Faculty of Medicine is Life Sciences and Medicine Library serves students multidisciplinary, as scientists and clinicians combine and staff and is the center of a consortium of 15 efforts in basic and translational research. Research hospital libraries. is conducted in the laboratories on the TAU campus, The student body is made up of 750 Israeli students and in the clinical facilities affiliated to the Faculty. enrolled in the 6-year M.D. degree program, 300 The Faculty of Medicine includes the Sackler School American and Canadian students enrolled in a of Medicine, the School of Health Professions, the 4-year M.D. program chartered by the State of School of Public Health, and the School of Dental New York and accredited by the State of Israel, Medicine. Education takes place in all these schools and a 4-year program for Israeli students for the and in the Graduate School of Medicine, School of Continuing Medical Education, the New York M.D. degree, with 260 students. Approximately State American Program and the B.Sc. Program in 200 students study dental medicine in a six-year Medical Life Sciences. This network of preclinical program where they are awarded the D.M.D. degree and clinical teams helps realize the ultimate goals and another 2,000 students are enrolled in the of the research: the basic understanding of human health professions programs where they will earn pathophysiology and the prevention, diagnosis and degrees in Communications Disorders, Nursing, treatment of disease. The research of Preclinical Physical Therapy and Occupational Therapy. faculty members from the Sackler School of Medicine Sackler’s Graduate School for Advanced Studies are featured in this research brochure. trains approximately 800 masters and doctoral level students in the biomedical disciplines, with a The Faculty of Medicine engages in joint teaching special emphasis on a multidisciplinary approach and and research programs with nearly every faculty at application of fundamental knowledge to important TAU, including the Wise Faculty of Life Sciences, biomedical problems. the Sagol School of Neuroscience, the Edmond J. Safra Bioinformatics Center, the TAU Center for The Sackler Faculty of Medicine is led by the Dean, Nanoscience and Nanotechnology, and the Edmond Professor Ehud Grossman; Vice Deans Prof. Karen J. Safra Center for Ethics, and multi-nationally with Avraham, Prof. Iris Barshack, Prof. Moshe Phillip, schools, hospitals and research centers throughout Prof. Anat Lowenstein, Prof. Ami Fishman, Prof. the world. The Sackler faculty is known for research Arnon Wiznitzer and Assistant to the Dean, Ms. in the following areas: cancer biology, stem cells, Michal Gilboa. Sackler Faculty of Medicine Research 2020 3 The Sackler Faculty of Medicine Table of Contents Cancer and Molecular Therapies 8 Dr. Yaron Carmi, Ph.D. 9 Prof. Neta Erez, Ph.D. 11 Prof. Zvi Fishelson, Ph.D. 14 Prof. Tamar Geiger, Ph.D. 16 Prof. Shai Izraeli, M.D 19 Prof. Yona Keisari, Ph.D. 23 Prof. Rafi Korenstein, Ph.D. 25 Prof. Rina Rosin-Arbesfeld, Ph.D. 27 Prof. Ronit Satchi-Fainaro, Ph.D. 30 Prof. Yosef Shiloh, Ph.D. 35 Prof. Ilan Tsarfaty, Ph.D. 37 Cardiovascular Research and Diseases 39 Prof. Bernard Attali, Ph.D. 40 Prof. Nathan Dascal, Ph.D. 42 Dr. Michal Katz-Leurer, Ph.D. 44 Prof. Daniel Khananshvili, Ph.D. 46 Prof. Jonathan Leor, M.D. 49 Dental Health and Medicine 52 Dr. Lihi Adler-Abramovich, Ph.D. 53 Prof. Tamar Brosh, Ph.D. 57 Prof. Ilana Eli, D.M.D. 59 Dr. Rachel Sarig, Ph.D., D.M.D. 60 Diabetes, Metabolic and Endocrine Diseases 62 Prof. Shimon Efrat, Ph.D. 63 Prof. Koret Hirschberg, Ph.D. 65 Dr. Limor Landsman, Ph.D. 67 Prof. Drorit Neumann, Ph.D. 69 Prof. Edgar Pick, M.D., Ph.D. 71 Prof. Haim Werner, Ph.D. 73 Prof. Efrat Wertheimer, MD., PhD. 76 Genomics & Personalized Medicine 78 Prof. Gil Ast, Ph.D. 79 Prof. Karen B. Avraham, Ph.D. 81 Dr. Ran Elkon, Ph.D. 84 Prof. David Gurwitz, Ph.D. 86 Prof. Carmit Levy, Ph.D. 88 Prof. Zvi (Gregory) Livshits, Ph.D. 90 Prof. Noam Shomron, Ph.D. 93 Sackler Faculty of Medicine Research 2020 4 The Sackler Faculty of Medicine Hearing, Language & Speech Sciences and Disorders 98 Dr. Noam Amir, D.Sc. 99 Prof. Ofer Amir, Ph.D. 101 Dr. Daphne Ari-Even Roth, Ph.D. 103 Dr. Katy Borodkin, Ph.D. 105 Prof. Yael Henkin, Ph.D. 107 Prof. Minka Hildesheimer, Ph.D. 109 Prof. Liat Kishon-Rabin, Ph.D. 111 Prof. Tova Most, Ph.D. 113 Prof. Chava Muchnik, Ph.D. 115 Prof. Dorit Ravid, Ph.D. 116 Infectious Diseases 117 Prof. Elhanan Borenstein, Ph.D. 118 Dr. Natalia T. Freund, Ph.D. 122 Prof. Fuad Iraqi, Ph.D. 124 Dr. Oren Kobiler, M.D., Ph.D. 126 Prof. Nir Osherov, Ph.D. 127 Prof. Udi Qimron, Ph.D. 129 Dr. Dor Salomon, Ph.D. 131 Prof. Esther Segal, Ph.D. 133 Dr. Ella Sklan, Ph.D. 135 Inflammatory and Autoimmune Diseases 137 Dr. Asaf Madi, Ph.D. 138 Prof. Ariel Munitz, Ph.D. 140 Dr. Mordechay (Motti) Gerlic, Ph.D. 142 Prof. Ronit Sagi-Eisenberg, Ph.D. 145 Medical Education and Ethics 147 Dr. Oren Asman, LL.D., Adv. 148 Prof. Yechiel Michael Barilan, M.D., M.A. 150 Dr. Orit Karnieli-Miller, Ph.D. 152 Nervous System and Brain Disorders 154 Prof. Ruth Ashery-Padan, Ph.D. 155 Dr. Avraham Ashkenazi, Ph.D. 157 Prof. Hagit Eldar-Finkelman, Ph.D. 159 Dr. Jason Friedman, Ph.D. 161 Prof. Illana Gozes, Ph.D. 163 Dr. Yoni Haitin, Ph.D. 167 Prof. Talma Hendler, M.D., Ph.D. 169 Prof. Dario G. Liebermann, Ph.D. 173 Prof. Ilana Lotan, Ph.D. 175 Sackler Faculty of Medicine Research 2020 5 The Sackler Faculty of Medicine Dr. Yuval Nir, Ph.D. 177 Prof. Daniel Offen, Ph.D. 179 Dr. Moshe Parnas, Ph.D. 182 Dr. Eran Perlson, Ph.D. 183 Prof. Chaim G. (Chagi) Pick, Ph.D. 185 Prof. Moshe Rehavi, Ph.D. 188 Dr. Moran Rubinstein, Ph.D. 190 Prof. Naphtali Savion, Ph.D. 192 Prof. Inna Slutsky, Ph.D. 193 Prof. Arieh S. Solomon, M.D., Ph.D. 195 Dr. Eran Stark, M.D., Ph.D. 196 Dr. Ido Tavor, Ph.D. 198 Nursing, Occupational and Physical Therapy 200 Dr. Michal Avrech Bar, Ph.D., O.T. 201 Dr. Tami Bar-Shalita, Ph.D., O.T. 203 Prof. Sivia Barnoy, R.N., Ph.D. 205 Dr. Orit Bart, Ph.D., OTR 207 Prof. Ruth Defrin, Ph.D. 209 Dr. Michal Itzhaki, R.N., Ph.D. 212 Dr. Ilya Kagan, R.N., Ph.D. 214 Prof. Silvia Koton, Ph.D., M.Occ.H., R.N. 216 Dr. Lena Lipskaya-Velikovsky, Ph.D., O.T. 218 Dr. Alon Kalron, Ph.D., P.T. 219 Dr. Youssef Masharawi, Ph.D., B.P.T. 222 Dr. Semyon Melnikov, R.N. Ph.D. 224 Dr. Sigal Portnoy, Ph.D. 226 Dr. Debbie Rand, Ph.D., O.T. 228 Prof. Navah Z. Ratzon, Ph.D., O.T. 230 Dr. Angela Ruban, Ph.D. 232 Dr. Miriam Theilla, Ph.D. 233 Public Health 235 Dr. Bruria Adini, Ph.D. 236 Prof. Daniel I. Cohen, Ph.D. 238 Prof. Jiska Cohen-Mansfield, Ph.D. 240 Dr. Yftach Gepner, Ph.D. 243 Prof. Yariv Gerber, Ph.D. 246 Prof. Uri Goldbourt, Ph.D. 248 Dr. Israel Ph.D. 250 Prof. Liat Lerner-Geva, M.D., Ph.D. 252 Prof. Khitam Muhsen, Ph.D. 256 Prof. Chava Ph.D. 259 Sackler Faculty of Medicine Research 2020 6 The Sackler Faculty of Medicine Prof. Laura (Leah) J. Ph.D. 261 Reproduction, Development and Evolution 263 Dr. Limor Broday, Ph.D.
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