From: ITNDaily Subject: Mount Sinai In The News - August 1, 2018 Date: Wednesday, August 01, 2018 12:47:01 PM Attachments: ATT00001.txt
In the News August 1, 2018
UPI – August 1 Study: Certain Drug Cocktails Better Attack Cancer, Lessen Side Effects — Allen Cone Certain drug cocktails attack cancer more efficiently and lessen common side effects, according to a study Researchers at Mount Sinai studied the combination of chemotherapy, anti-tumor antibiotics and chemical compounds at low doses, called "network break" cocktails. Their findings were published Wednesday in the journal Cell Research. "Our work addresses the central question faced by physicians who treat cancer patients: how do targeted therapies both promote resistance in cancer cells and evoke toxic side effects in patients?" Tirtha K. Das, MD, assistant professor of cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai, said in a news release. - Tirtha K. Das, MD, Assistant Professor, Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai Learn more: www.upi.com/Health_News/2018/08/01/Study-Certain-drug-cocktails-better-attack-cancer- lessen-side-effects/9281533124877/
Infectious Disease Advisor – August 1 Increased Levels of Human Herpesvirus ID'd in Alzheimer's Subjects with Alzheimer's disease have increased levels of two strains of human herpesvirus. Ben Readhead, MBBS, biomedical informatics research scientist at the Icahn School of Medicine at Mount Sinai, and colleagues constructed multiscale networks of the late-onset Alzheimer's disease-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions using tissue from human postmortem samples. The researchers found that, compared with controls, subjects with Alzheimer's disease had increased human herpesvirus 6A (HHV-6A) and HHV-7. In two additional, independent, and geographically dispersed cohorts, these results were replicated. - Benjamin P. Readhead, MBBS, Biomedical Informatics Research Scientist, Icahn Institute for Multiscale Biology, Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai Learn more: https://www.infectiousdiseaseadvisor.com/sexually-transmitted-diseases/increased-levels- of-human-herpes-alzheimers/article/784373/
Laboratory Equipment – August 1 Scientists Mapped Magnetic Particles in the Human BrainX — Ludwig Maximilians Many living organisms, such as migratory birds, are thought to possess a magnetotactic sense that enables them to respond to the Earth's magnetic field. Whether or not humans are capable of sensing magnetism is the subject of debate. However, several studies have already shown that one of the preconditions required for such a magnetic sensory system is indeed met: magnetic particles exist in the human brain. In collaboration with Patrick Hof, MD, professor of neuroscience, geriatrics and palliative medicine, and ophthalmology at the Icahn School of Medicine at Mount Sinai, they also hope to perform analogous localization studies on far larger mammals like whales. These huge marine mammals are known to migrate between feeding and breeding grounds across great distances in the world's oceans. - Patrick Hof, MD, Professor, Neuroscience, Geriatrics and Palliative Medicine, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://www.laboratoryequipment.com/news/2018/08/scientists-mapped-magnetic-particles- human-brain
Patch.com – July 31 These Are The Best Employers For Women In NYC — Adam Nichols A new list from Forbes ranks the best employers for women in America. Of the nation's 300 best companies for women, almost 10 percent are in New York City. A ranking put together by Forbes identified 29 city-based companies as being outstanding for their female employees. Its conclusions were based on surveys of thousands of workers and focused on things like parental leave and pay equity. One of the companies that made the cut was Icahn School of Medicine at Mount Sinai. - Icahn School of Medicine at Mount Sinai Learn more: https://patch.com/new-york/new-york-city/these-are-best-employers-women-nyc
Psychiatric Times – July 31 Addressing Depression: The World’s Largest Health Problem — James Murrough, MD, PhD Depression is the world’s largest health problem, accounting for more disability than any other disease worldwide. Many patients with major depressive disorder are never diagnosed, and those who are diagnosed may not receive adequate treatment due to factors that include stigma, lack of understanding of the medical nature of depression in the community, and access to care. James Murrough, MD, assistant professor of psychiatry, neuroscience, and director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai writes that despite the scope and magnitude of the problem, the field may be witnessing a turning point in our capacity to understand and treat depression. “Despite the sobering scale of the problem, tangible progress in depression research and treatment should encourage optimism in clinicians and patients alike. With continued work, the future will continue to brighten.” - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.psychiatrictimes.com/special-reports/addressing-depression-worlds-largest- health-problem
Cure Today – July 31 Two Large Trials Investigate Combination Immunotherapy In Bladder Cancer — Brielle Urciuoli With five immunotherapy drugs approved in the bladder cancer space, the next question researchers find themselves asking is whether these drugs would work better alone or as part of a combination for patients with metastatic disease. Two clinical trials – Imvigor130 and CheckMate-901 – may soon provide that answer. “The takeaway from the first-line trials in metastatic bladder cancer is the questions that are being asked right now are very practical, straightforward questions, but they are questions that can only be answered in the context of a large, randomized clinical trial,” said Matthew Galsky, MD, professor of medicine, urology, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. “We can speculate about that all we want, but the only way to determine those answers definitively is through prospective clinical trials,” he added. - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Icahn School of Medicine at Mount Sinai Learn more: https://www.curetoday.com/articles/two-large-trials-investigate-combination- immunotherapy-in-bladder-cancer
Medical Xpress – July 31 Scientists May Have Cleared Gene Therapy Hurdle Scientists may have found a way to slip a special type of disease-fighting virus past the guard of the body's immune system and into targeted cells where it can do its intended work, according to new research. A harmless virus called adeno-associated virus, or AAV, has the ability to help the body. It can deliver therapeutic genetic material into whatever damaged or diseased cells it’s been genetically engineered to target. But the AAV first needs to make it past the antibodies that want to shut it down. Researchers may have found a way to do just that, said Marta Adamiak, senior research associate in the department of medicine and the division of cardiology at the Icahn School of Medicine at Mount Sinai, the lead investigator on a study. She discussed the research at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions meeting in San Antonio. Adamiak said researchers discovered that encasing the AAV inside containers, often called vesicles or exosomes that are naturally secreted from cells can help the virus travel easily without being detected by antibodies. - Marta Adamiak, Senior Research Associate, Department of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-07-scientists-gene-therapy-hurdle.html
Healio: Endocrine Today – July 31 Experts Push For Transgender Health Priorities In Congressional Briefing— Regina Schaffer There is a “durable, biological underpinning” to gender identity that should be considered in any policy determinations that impact transgender people, including antidiscrimination legislation and the coverage of medically necessary treatments for gender incongruence, according to several speakers at an Endocrine Society congressional briefing on transgender health. Despite years of growing awareness of transgender people, and even transgender celebrities, only recently has a noticeable shift begun among the public regarding how to best approach treating people with gender incongruence, said Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai, during a briefing. That shift, he said, is due in part to an increasing evidence base that points to the biological underpinnings of gender identity. “The establishment medical community recognizes better than it ever did before the biology of gender identity,” Dr. Safer said. - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/endocrinology/practice-management/news/online/%7B6857cf2f- 1205-45e8-b630-dcbec10d11f7%7D/experts-push-for-transgender-health-priorities-in-congressional- briefing
HealthDay – July 31 Brain’s ‘Plasticity’ Amazes As Boy Recovers From Drastic Surgery — Dennis Thompson The developing brain of a growing child has incredible ways of compensating for the loss of an essential brain region, a new case study shows. A young boy has retained his ability to recognize faces even though surgeons removed one-sixth of his brain, including the region that normally handles that task, his doctors said. Essentially, the other side of the 10-year-old's brain has shouldered the added burden of facial recognition on top of its normal duties, in an astounding feat of adaptation. Even more compelling, the boy's intellect, visual perception and object recognition skills have all remained age-appropriate, even with a large portion of his brain gone. This study shows that "plasticity is real. Plasticity is key—your brain's golden art of adaptation," said Steven Wolf, MD, associate professor of neurology and pediatrics at the Icahn School of Medicine at Mount Sinai. "If we get to these kids when they're young enough, before they lay their permanent pathways, the brain is plastic enough for it to adapt and to overcome," said Dr. Wolf. His center has performed the procedure around 500 times over the past decade. - Steven Wolf, MD, Associate Professor, Neurology, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Pediatric Epilepsy, Co-Director, Epilepsy Unit, Mount Sinai Beth Israel, Director, Pediatric Neurology, Mount Sinai St. Luke’s-Mount Sinai West, Co-Director, Tuberous Sclerosis Clinic Learn more: https://consumer.healthday.com/cognitive-health-information-26/epilepsy-news-235/brain-s- plasticity-amazes-as-boy-recovers-from-drastic-surgery-736338.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-07-brain-plasticity-amazes-boy-recovers.html U.S. News & World Report https://health.usnews.com/health-care/articles/2018-07-31/brains-plasticity- amazes-as-boy-recovers-from-drastic-surgery
Specialty Pharmacy Times – July 31 FDA Grants Fast Track Designation To Hepatitis B Drug The FDA recently granted Fast Track designation to Assembly Biosciences, Inc’s novel treatment for patients with chronic hepatitis B virus (HBV) infection. The drug, ABI-H0731, is the manufacturer’s lead oral HBV core inhibitor. It is currently being evaluated in a pair of global phase 2a proof of concept studies. "Even with indefinite treatment with the currently available nucleoside and nucleotide inhibitors, we are not able to fully suppress viral replication, which will be necessary for patients to achieve a cure for chronic HBV," said Douglas T. Dieterich, MD, director of the Institute of Liver Medicine and professor of medicine and liver disease at the Icahn School of Medicine at Mount Sinai, who is an investigator on both trials. "Core inhibitors target different parts of the HBV life cycle than the current therapies and may result in both greater viral suppression and increased loss of cccDNA, which is central to HBV persistence. Combining these new mechanisms of action with existing direct acting antivirals looks promising. I look forward to exploring this further in the trials and seeing the results." - Douglas Dieterich, MD, Director, Institute of Liver Medicine, Professor, Liver Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.specialtypharmacytimes.com/news/fda-grants-fast-track-designation-to- hepatitis-b-drug
MedPage Today – July 31 Soccer Heading May Be Worse For Women — Judy George Women may experience more extensive changes in brain tissue after repetitive soccer heading, a neuroimaging analysis of amateur athletes suggests. "This study adds to a growing body of literature pointing to biological differences in concussion risk and response between men and women," said Kristen Dams-O'Connor, PhD, associate professor of rehabilitation medicine and neurology at the Icahn School of Medicine at Mount Sinai and co-director of the Brain Injury Research Center of Mount Sinai, who was not involved in the research. “If women experience greater cumulative consequences of sub-concussive head trauma as suggested in this paper, then over time, the threshold for sustaining a concussion – or the force required to result in a clinical concussion – is lowered,” she said. “Similarly, if the brain microstructure is already altered by sub-clinical, sub-concussive head trauma, a concussion would understandably result in more significant symptoms.” - Kristen Dams-O’Connor, PhD, Associate Professor, Rehabilitation Medicine, Neurology, Icahn School of Medicine at Mount Sinai, Co-Director, The Brain Injury Research Center of Mount Sinai Learn more: https://www.medpagetoday.com/neurology/headtrauma/74332
MDLinx – July 30 Negative Pressure Wound Therapy No Better Than Standard Care For Open Traumatic Wounds— Marilynn Larkin For open traumatic wounds involving fracture or soft tissue, there is "no clear difference" between standard care and negative pressure wound therapy (NPWT), and the latter is unlikely to be cost- effective, according to a recent Cochrane Review. Harvey Himel, MD, assistant clinical professor of surgery at the Icahn School of Medicine at Mount Sinai said, “One of the early indications for NPWT has to help with the aftermath of crush injury, specifically in accelerating the healing of the fasciotomy incision, which has necessitated by the profound swelling of the zone of injury that would lead to a compartment syndrome.” He added that, “Prior to the development of NPWT, these extensive incisions would be let to heal by secondary intention or closed with a skin graft. In both cases, they would generally leave a disfiguring scar. The use of NPWT would minimize the scar while often obviating the need for a skin graft. The treatment worked best when the wound was deemed viable throughout prior to initiation of NPWT.” - Harvey N. Himel, MD, Assistant Clinical Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.mdlinx.com/orthopedics/top-medical-news/article/2018/07/30/7539765 Additional coverage: MD Alert http://www.mdalert.com/news/article/negative-pressure-wound-therapy-no-better-than- standard-care-for-open-traumatic-wounds
Healthline – July 31 Depression: The Growing American Mental Health Storm — Temma Ehrenfeld Recent reports show depression is one of the greatest mental health challenges facing Americans today. In the last decade, Lisa Cohen, PhD, professor of psychiatry at the Icahn School of Medicine at Mount Sinai, has seen a bump in college students and young adults from stable families landing in the hospital at risk for suicide after a minor stress. In part, that may be because they’ve been overprotected – but the overall ramp up in stress during early adulthood is also steeper today that it’s been in the past. “While earlier generations could rely on a steady supply of jobs in large, stable companies, this is no longer the case,” said Dr. Cohen. “Many young people expect to work in start-ups or to work freelance. They look ahead to an economic life of uncertainty, without a clear path to success or even self-sufficiency.” Prompt treatment for depression is important to overall health. Untreated depression raises the risk of stroke, heart attacks, dementia and Parkinson’s – especially in older people. - Lisa Cohen, PhD, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/depression-the-growing-american-mental-health- storm
New York Magazine – July 31 Do Lip Plumpers Actually Work (and How)? — Lori Keong The pursuit of bigger lips is not a new trend. Every dermatologist that I spoke to for this story said that topical lip plumpers can produce a notable increase in lip volume for up to a few hours, but it really depends on what’s in them. Traditionally, lip plumpers have relied on irritants — peppermint oil, wintergreen, capicum (a derivative of chile peppers), and cinnamon — or inflammatory ingredients like bee venom and niacin to swell the lips. Hooman Khorasani, MD, assistant clinical professor of dermatology and chief of the division of dermatologic and cosmetic surgery at the Icahn School of Medicine at Mount Sinai, explains that these aren’t stimulating an allergic reaction (though that is a risk). Instead, they’re causing a mild irritation that increases blood flow, inducing temporary tingling and swelling as a result. That conventional approach is very different to that of plumpers that contain hyaluronic acid, which claim to boost lip size through absorbing hydrating molecules through the skin. Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai, explains that hyaluronic-acid lip plumpers “pull hydration to the surface of the skin. Just as it is used in skin-care products, hyaluronic acid can enhance hydration and plumpness of lips.” Dr. Zeichner says that they’re a better alternative to irritants because “they do offer moisturizing benefits which make the lips feel better.” - Hooman Khorasani, MD, Assistant Clinical Professor, Dermatology, Chief, Division of Dermatologic and Cosmetic Surgery, Icahn School of Medicine at Mount Sinai - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: http://nymag.com/strategist/article/best-lip-plumpers-how-they-work.html
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 2, 2018 Date: Thursday, August 02, 2018 12:22:23 PM Attachments: ATT00001.txt
In the News August 2, 2018
Health News Digest – July 31 Correcting Breast Asymmetry after Cancer Surgery and Reconstruction The goal of breast reconstruction after mastectomy is to restore symmetry – to create a breast with the shape and softness of the original that is in proportion with her opposite breast as well as the rest of a woman's body. “Breast reconstruction is often a process rather than a single surgical procedure,” says Constance M. Chen, MD, director of microsurgery at The New York Eye and Ear Infirmary of Mount Sinai and clinical assistant professor of surgery at the Icahn School of Medicine at Mount Sinai. “Lack of symmetry in mastectomy patients after reconstruction can be corrected with adjustments to the reconstructed breast or to its unaffected 'sister.' Asymmetry may also be a problem for women who have had a lumpectomy that conserved the breast but left them with breasts that no longer match. For all these women, advanced surgical techniques that address their individual needs can produce an improved symmetrical outcome to help put cancer behind them.” - Constance Chen, MD, Director, Microsurgery, The New York Eye and Ear Infirmary of Mount Sinai, Clinical Assistant Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.healthnewsdigest.com/news/Cancer_Issues_660/Correcting-Breast-Asymmetry- after-Cancer-Surgery-and-Reconstruction.shtml
Science Daily – August 1 Novel Drug Cocktails Strengthen Targeted Cancer Therapies While Lessening Side Effects Mount Sinai researchers have discovered that certain drug cocktails help targeted therapies attack cancer more efficiently while lessening common side effects, according to a study published today in Cancer Research. "Targeted therapies have revolutionized cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy and lower side effects compared to chemotherapy," said Tirtha K. Das, MD, assistant professor of cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai. "Yet clinical trials show that targeted therapies still elicit side effects, and in many cases cancer cells develop resistance mechanisms to these therapies, eventually leading to disease progression in patients. Our work addresses the central question faced by physicians who treat cancer patients: how do targeted therapies both promote resistance in cancer cells and evoke toxic side effects in patients?" - Tirtha K. Das, MD, Assistant Professor, Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai MD, assistant professor of cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai, Learn more: https://www.sciencedaily.com/releases/2018/08/180801083930.htm Additional coverage: Technology Networks: https://www.technologynetworks.com/tn/news/novel-drug-cocktails-strengthen- targeted-cancer-therapies-whilst-reducing-adverse-effects-307070 Tekk TV: https://www.tekk.tv/welt/studie-bestimmte-drogencocktails-greifen-besser-krebs-an- verringern-nebenwirkungen/
Arab Window – August 1 New Study: These Viruses Have A Role In Alzheimer's Disease Analyzing large lists of data from anatomical brain samples of people with Alzheimer's disease and healthy people has revealed new evidence that viral species, especially herpes, can play a role in the biology of Alzheimer's disease. The research group, which includes experts from the Icahn School of Medicine at Mount Sinai, intends to explore whether drugs used to treat other diseases can be used to treat Alzheimer's. They designed their studies to plan and compare the biological networks underlying Alzheimer's disease. Researchers found that the biology of Alzheimer's disease is likely to be affected by a complex set of genetic factors of the virus and host, in addition to identifying specific pathways and biological networks that can be tested. - Icahn School of Medicine at Mount Sinai Learn more: https://arabwindow.net/health/news43989.html
KSAT-TV (ABC News San Antonio, TX affiliate) – August 2 Cardiologists using tiny pacemaker for kids with congenital heart disease Bundle branch block is a congenital heart condition that causes the electrical impulses in the heart to misfire. People with the condition often need a pacemaker to keep their hearts in sync. Now, cardiologists at Mount Sinai Hospital in New York are using a recently approved tiny wireless device in kids, so they don’t miss a beat. Three of the Anthony family’s four children have a condition that blocks the pathway that sends electrical impulses to the heart. Two sons, two pacemakers, over five days. But for Sam, cardiologists were able to implant this tiny wireless pacemaker, approved in 2016 but used now in a handful of kids. Barry Love M.D, a pediatric cardiologist at The Mount Sinai Hospital inserted the Micra pacemaker by threading a catheter through a vein. Dr. Love said, “This pacemaker is entirely contained in the heart itself and because of that he’ll be able to participate in sports and activities with really minimal to no restrictions.” - Barry Love M.D, Assistant Professor of Pediatric Cardiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.ksat.com/health/cardiologists-using-tiny-pacemaker-for-kids-with-congenital- heart-disease
Mobi Health News – August 1 To Prevent The Next Theranos, Industry-Wide Collaboration On Evidence-Based Therapeutics Is Mandatory — Dave Muoio Ashish Atreja MD, MPH, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai is an unabashed proponent of digital health. As chief innovation and engagement officer, he has contributed to a number of the organization’s digitally-focused initiatives and often speaks of the benefits these technologies can bring to care. However, for digital health and medicines to avoid major pitfalls during its rapid sprint toward wider adoption, he stressed the need for healthcare players to collectively demand more stringent evidence of efficacy from these interventions. “If we look at [the year] 2020, you’re going to see more virtual touch points, and we already have a theme of digital medicine,” Dr. Atreja said this week during a session at the Digital Health Care Innovations Congress in Boston. “But there are major barriers that we have to solve. None of the startup companies, none of the hospitals can solve this — we have to solve it together as an ecosystem. And that barrier is evidence.” - Ashish Atreja, MD, MPH, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Sinai AppLab, Chief Technology, Innovation and Engagement Officer, The Mount Sinai Hospital Learn more: https://www.mobihealthnews.com/content/prevent-next-theranos-industry-wide- collaboration-evidence-based-therapeutics-mandatory
Ozarks First – August 1 Brain Stimulation Helping Parkinsons' Patients — Kenneth Craig Actor Alan Alda revealed on CBS This Morning, he has Parkinson's Disease. Melissa Hahn and her father Edward Hahn are thankful for the new technology allowing them to enjoy life's simple pleasures. Both are living with Parkinson's Disease. Melissa was taking more than 10 pills a day and had severe tremors and cramping when she decided brain surgery was her only option. Last summer the 41-year-old underwent deep brain stimulation, or DBS at Mount Sinai Hospital in New York. "In essence that's a pacemaker for the brain," says Brian Kopell, MD, director of the Center for Neuromodulation at the Mount Sinai Health System. While DBS has a long history, Dr. Kopell is using the latest technology approved by the FDA. During surgery, leads are implanted that deliver electrical impulses to control Parkinson's symptoms."Giving us an ability to get better perhaps at side effect control, perhaps even better symptom control," Weeks later, that stimulation is fine-tuned using an iPad. In a follow up appointment doctors gradually turned the technology off - giving Melissa's father all he needed to see. - Brian Kopell, MD, Professor, Neurosurgery, Psychiatry, Neurology and Neuroscience, Director, Center of Neuromodulation at Mount Sinai Health System. Learn more: https://www.ozarksfirst.com/news/brain-stimulation-helping-parkinsons- patients/1338270728
Consumer Reports – August 1 How to Get Better Protection From Sunscreen — Sally Wadyka If you diligently apply—and reapply—your sunscreen to all exposed skin when you’re outside, you probably think your skin is safe. But dermatologists warn that few people actually use enough sunscreen to get anything even close to the SPF stamped on the bottle. “Sunscreen testing in the lab does not always correlate with how well it performs in the real world, mainly because consumers are applying about half as much sunscreen as they should,” says Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.consumerreports.org/sun-protection/get-better-protection-from-sunscreen/
Greatist – August 2 One Super-Surprising Strategy to Improve Your Workouts —Shaun Dreisbach Given our more-is-more culture, the idea of laying off the gym for a while may seem counterintuitive. As though in a matter of days, you'll somehow completely devolve and wake up with zero muscle tone and the aerobic capacity of an asthmatic chain smoker. But if you're a regular exerciser—particularly of the go-hard-or-go-home variety—a little rest may actually be exactly what you need, according to Richard Weil, MEd, exercise physiologist and director of the Mount Sinai St. Luke’s Weight Loss Program "Conventional fitness wisdom has always been to wait 48 hours before working the same muscle group again," he says. "But muscles don't repair quickly, and if you've exercised really hard, it could take up to five full days for you to fully recover. It's during that downtime that you get stronger." - Richard Weil, MEd, Exercise Physiologist, Director, Mount Sinai St. Luke’s Weight Loss Program Learn more: https://greatist.com/move/how-long-should-you-rest-between-workouts
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 3, 2018 Date: Friday, August 03, 2018 11:33:42 AM Attachments: ATT00001.txt
In the News August 3, 2018
HealthIT Analytics – August 3 How Artificial Intelligence Is Changing Radiology, Pathology — Jessica Kent Artificial intelligence and machine learning tools have the potential to analyze large datasets and extract meaningful insights to enhance patient outcomes, an ability that is proving helpful in radiology and pathology. AI and machine learning have demonstrated great potential in supplementing and verifying the work of clinicians, particularly in the complex field of imaging analytics. Mount Sinai Health System is interested in advancing precision medicine with imaging analytics. The organization created an imaging research warehouse to grant researchers access to imaging and clinical data from more than one million patients. Researchers developing AI and machine learning algorithms can use the warehouse data to build innovative tools and discover new ways to treat disease. - Mount Sinai Health System Learn more: https://healthitanalytics.com/news/how-artificial-intelligence-is-changing-radiology- pathology
Technology Networks – August 2 Novel Drug Cocktails Strengthen Targeted Cancer Therapies Whilst Reducing Adverse Effects Mount Sinai researchers have discovered that certain drug cocktails help targeted therapies attack cancer more efficiently while lessening common side effects, according to a study published in Cancer Research. “Targeted therapies have revolutionized cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy and lower side effects compared to chemotherapy,” said Tirtha K. Das, PhD, assistant professor of cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai. “Yet clinical trials show that targeted therapies still elicit side effects, and in many cases cancer cells develop resistance mechanisms to therapies, eventually leading to disease progression in patients. Our work addresses the central question faced by physicians who treat cancer patients: how do targeted therapies both promote resistance in cancer cells and evoke toxic side effects in patients?” This study, which created drug cocktails from targets found in genetic and drug screening, provides an innovative way to bolster current efforts at using targeted therapies to treat patients. - Tirtha K. Das, MD, Assistant Professor, Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai Learn more: https://www.technologynetworks.com/cancer-research/news/novel-drug-cocktails- strengthen-targeted-cancer-therapies-whilst-reducing-adverse-effects-307070
CBS News – August 2 New Hope In The Fight Against Parkinson’s Disease — Kenneth Craig It’s estimated that about a million people in the U.S. are living with Parkinson’s; the progressive nervous system disorder is debilitating and has no cure. Melissa Hahn and her father, Edward Hahn, are thankful for the new technology allowing them to enjoy life’s simple pleasures. Both are living with Parkinson’s Disease. Melissa was taking more than ten pills each day and had severe tremors and cramping when she decided brain surgery was her only option. Last summer, the 41-year-old underwent deep brain stimulation or DBS, at The Mount Sinai Hospital. “In essence, that’s a pacemaker for the brain,” said Brian Kopell, MD, professor of neurosurgery, neurology, neuroscience, psychiatry, and director of the Center of Neuromodulation at the Mount Sinai Health System. While DBS has a long history, Dr. Kopell is using the latest technology approved by the FDA. During surgery, leads are implanted that deliver electrical impulses to control Parkinson’s symptoms. Weeks later, the stimulation is fine-tuned using an iPad. Melissa and her father are now enjoying activities they thought they would never do again. Both still take medication, but only a fraction of the pills they once relied on. Their only regret is not getting the surgery sooner. - Brian Kopell, MD, Professor, Neurosurgery, Psychiatry, Neurology, Neuroscience, Icahn School of Medicine at Mount Sinai, Director, Center of Neuromodulation at Mount Sinai Health System Learn more: https://www.youtube.com/watch?v=DQpliFSUwnw
ETF Trends – August 3 The Mount Sinai Hospital Revolutionizing Physical Exams — Ben Hernandez The Mount Sinai Hospital in New York City has been developing its Lab100 program over the last few years, which is set to revolutionize the way patients receive a physical exam. Lab100 incorporates the latest in technologies, such as virtual reality and 3D body scanners, while at the same time, still maintaining the patient-provider relationship aspect. - David Stark, MD, Assistant Professor, Health System Design and Global Health, Icahn School of Medicine at Mount Sinai, Medical Director, Institute for Next Generation Health Care - Joel Dudley, PhD, Director, Institute for Next Generation Healthcare, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System Learn more: https://www.etftrends.com/robotics-ai-channel/mount-sinai-revolutionizing-physical-exams/
Healio – August 3 Ablation Of Anal HSL Results In Quicker Resolution In Patients With HIV— Caitlyn Stulpin Researchers said that infrared coagulation ablation of anal canal high-grade squamous intraepithelial lesions, or HSILs, is more likely to result in a complete or partial resolution of HSILs than monitoring alone in patients living with HIV, according to the results of a randomized clinical trial. “The overall strength of this study rests in the fact that it is the first multicenter, prospective, randomized trial powered to determine whether or not HSIL ablation is superior to alone in clearing HSIL in HIV-infected individuals,” Stephen E. Goldstone, MD, assistant clinical professor of surgery at the Icahn School of Medicine at Mount Sinai, and colleagues wrote in Clinical Infectious Diseases. “IRC ablation of anal canal HSIL is more likely to result in a complete or partial resolution of HSIL than [active monitoring] alone in those with small and fewer lesions,” the researchers wrote. - Stephen E. Goldstone, MD, Assistant Clinical Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/infectious-disease/hiv-aids/news/in-the-journals/%7B811351bb- 2785-4aaa-818a-05f500d976d0%7D/ablation-of-anal-hsil-results-in-quicker-resolution-in-patients-with-hiv
Mass Device – August 2 Abbott Wins FDA MR-Conditional Labeling For Infinity DBS — Fink Densford Abbott has won expanded FDA approval for magnetic resonance conditional labeling for its Infinity Deep Brain Stimulation system designed to treat individuals with Parkinson’s disease and essential tremors. The update will be delivers through an over-the-air software upgrade to all currently implanted Infinity IBS systems. “The announcement of the newly released MRI-compatibility of the Infinity DBS system reflects Abbott’s continued commitment to patient-centric, cutting-edge care – where the patient’s options are expanded by the therapy instead of limited by it,” said Brian Kopell, MD, professor of neurosurgery at the Icahn School of Medicine at Mount Sinai and director of the Center of Neuromodulation at the Mount Sinai Health System. - Brian Kopell, MD, Professor, Neurosurgery, Psychiatry, Neurology, Neuroscience, Icahn School of Medicine at Mount Sinai, Director, Center of Neuromodulation at Mount Sinai Health System Learn more: https://www.massdevice.com/abbott-wins-fda-mr-conditional-labeling-for-infinity-dbs/
MedPage Today – August 2 IL-23-Specific Antibody Ups Response In Anti-TNF-Refractory Crohn’s — Diana Swift Infusion of risankizumab increased clinical response and remission rates in moderate to severe refractory Crohn's disease (CD), with 53 percent of patients in remission at 26 weeks, an open-label extension study found. Jean-Frederic Colombel, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of the Susan and Leonard IBD Clinical Center at Mount Sinai, who was not involved in the study, said that although there were some original safety concerns about blocking both IL-12 and IL-23 in terms of infection risk, the safety profile proved not to be an issue in psoriasis. “And selectively blocking just IL-23 may actually be more beneficial in Crohn’s disease,” said Dr. Colombel, who is part of the trial group initiating phase III trials of risankizumab in CD – results in controlled clinical trials, he said, are generally not as positive as in "patient-cognizant" open-label studies. - Jean-Frédéric Colombel, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai Learn more: https://www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/74370
Prevention – August 2 11 Cold Medicines That Will Make You Feel Miserable — Anisa Aresenault When you’re feeling blocked up and stuffy from a cold or a sinus infection, the tissues and blood vessels of your nasal passages and sinuses swell up. “Decongestants work by shrinking the swelling around your nose, helping you breathe better,” said Benjamin Tweel, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. There are two main types of decongestants; the first being oral decongestants – including pills and syrups – which typically utilize the ingredients phenylephrine and pseudoephedrine. “As simple as it sounds, when I have a patient who has an upper respiratory infection, if I’m not concerned about a bacterial sinus infection (which would require antibiotics), I’ll usually just ask them to go to the pharmacy to find the box that matches their symptoms,” said Dr. Tweel. - Benjamin C. Tweel, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/health/a22619199/best-common-cold-medicines/
Allure Magazine – August 3 Trifarotene, A New Retinoid Treatment For Acne, May Soon Hit The Market — Macaela Mackenzie Retinoids rank high on many skin-care ingredients lists for a reason – they work, especially for fighting acne. But using retinoids for acne can also come with some not-so-desirable side effects, like dry, sensitive skin. Researchers conducted a study outlining the benefits of a new class of retinoids called trifarotene, which, in a nutshell, is reported to be more effective at topically treating acne with fewer side effects. Retinoids can do a variety of things to help your skin. “They prevent cells from sticking together and blocking the pores, reduce inflammation, and promote healthy cell turnover and exfoliation,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. Retinoids do this by binding to specific receptors in the skin, which promote these clear-skin effects. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/retinoid-trifarotene-acne-treatment
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 6, 2018 Date: Monday, August 06, 2018 1:20:42 PM Attachments: ATT00001.txt
In the News August 6, 2018
Crain’s New York Business – August 6 Notable Women In Health Care: Meet Health Care’s Leading Women Crain’s Custom is honored to present this inaugural section on Notable Women in Health Care to celebrate a history uniquely shaped by women. The list reflects the thousands of talented women in all corners of the industry. Health care is populated by lesser-known department chairs, ground-breaking researchers and women who lead charities that change the lives of millions of patients. The Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai congratulates colleagues and all of the talented women recognized by Crain’s as Notable Women in Health Care in New York City. - Barbara Barnett, MD, MHCDS, Senior Vice President, Chief Medical Officer, Mount Sinai Beth Israel - Tracy L. Breen, MD, FACP, Chief Medical Officer, Mount Sinai West - Susan B. Bressman, MD, Vice-Chair, Department of Neurology, Mount Sinai Health System, Chair, Department of Neurology, Mount Sinai Beth Israel, Mount Sinai West - Angela Diaz, MD, PhD, MPH, Director, Mount Sinai Adolescent Health Center - Elizabeth A. Howell, MD, MPP, Associate Dean, Academic Development, Director, The Blavatnik Family Women’s Health Research Institute, Icahn School of Medicine at Mount Sinai - Vicki LoPachin, MD, FACP, Chief Medical Officer, Senior Vice President, Mount Sinai Health System - Barbara T. Murphy, MB, BAO, BCh, Dean, Clinical Integration and Population Health, Icahn School of Medicine at Mount Sinai, Chair, Department of Medicine, Mount Sinai Health System - Margaret Pastuszko, Executive Vice President, Chief Strategy and Integration Officer, Mount Sinai Health System - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://www.crainsnewyork.com/assets/pdf/CN11652782.PDF
OncLive– August 3 Dr. Galsky On Neoadjuvant Immune Checkpoint Blockade In Bladder Cancer Matthew Galsky, MD, professor of medicine, urology, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, discusses neoadjuvant immune checkpoint inhibition in patients with bladder cancer. Historically, chemotherapy has been the standard of care in the neoadjuvant setting, followed by cystectomy in patients with cisplatin-ineligible muscle-invasive bladder cancer (MIBC). Two trials presented at the 2018 ASCO Meeting on neoadjuvant immune checkpoint blockade assessed either PD-1 or PD-L1 blockade in patients with MIBC. The only option for patients who are cisplatin-ineligible is surgery alone, Dr. Galsky said. Although single-arm studies are rarely practice changing, Dr. Galsky says that these studies will inform further studies that may transform care. - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Icahn School of Medicine at Mount Sinai Learn more: https://www.onclive.com/onclive-tv/dr-galsky-on-neoadjuvant-immune-checkpoint- blockade-in-bladder-cancer
Renal & Urology News – August 6 Prostate Cancer Brachytherapy Outcomes Linked To PSADT—Jody A. Charnow PSA doubling time (PSADT) can predict oncologic and survival outcomes among men who receive brachytherapy for localized prostate cancer (PCa), new study findings suggest. Results showed that shorter PSADT is associated with worse disease-specific, metastasis-free, and overall survival. “Given the variable trajectory of metastatic and recurrent PCa, strong prognostic factors such as PSADT may be able to select a group of patients who benefit from earlier or escalated systemic therapies such as androgen deprivation or cytotoxic chemotherapy,” Lucas Resende Salgado, MD, resident physician in radiation oncology at the Icahn School of Medicine at Mount Sinai, and colleagues wrote in a paper published in Brachytherapy. On multivariable analysis, PSADT was significantly associated with DSS and DM but not OS, which appears to be impacted mainly by initial age at diagnosis and disease stage, the investigators reported. - Lucas Resende Salgado, MD, Resident Physician, Radiation Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.renalandurologynews.com/prostate-cancer/psa-doubling-time-predicts- outcomes-from-prostate-cancer-brachytherapy/article/786136/
Endocrine News – August 6 Transgender Health – Endocrinologist As Local Expert— Derek Bagley A Clinical Endocrinology Update session presented by Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai and senior faculty of endocrinology at the Icahn School of Medicine at Mount Sinai, will address the special needs of this growing patient population. “The point will be to look at strategy for hormone care as well as the current concerns about potential pitfalls of hormone care and how those can be mitigated by monitoring them carefully if necessary and/or other interventions,” said Dr. Safer. “There will also be some discussion about how big those concerns really even seem to be based on the current literature and what the gaps are in terms of even making those assessments and then what the needs for future study are.” - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://endocrinenews.endocrine.org/ceu-preview-transgender-health-endocrinologist-as- local-expert/
Today Nigeria – August 6 Research Links Autism To Fertility Treatment Fertility treatments may increase the risk of autism in children, according to research published by the University of Haifa in northern Israel. In recent years, efforts have been made to identify the environmental factors that influence the development of autism. Some studies have found that there is no connection between fertility treatments and autism, especially In vitro fertilization treatments. Other studies have linked to individual hormones and autism. The new study, which also included researchers from the Mount Sinai Hospital and the Karolinska Institute in Sweden, included 108,548 boys, as boys have a higher risk of developing autism than girls. It was found that progesterone delivery before pregnancy may affect critical stages in fetal brain development. - Mount Sinai Hospital Learn more: https://www.today.ng/news/nigeria/links-autism-fertility-treatment-139272 Additional coverage: The Tribune https://www.tribuneindia.com/news/health/some-fertility-treatments-can-up-autism-risk- claims-study/633087.html
The Atlantic – August 5 Literature Should Be A Medical School Admissions Requirement “As a physician who teaches both ethics and creative writing to medical students and house officers, I appreciate the value of using fiction and narrative to enhance the training of future physicians,” writes Jacob Appel, MD, assistant professor of psychiatry, medical education and director of ethics education in psychiatry at the Icahn School of Medicine at Mount Sinai. “These tools are certainly helpful in cultivating humanistic and compassionate doctors. Ideally, admissions committees at medical school should be looking for students who are imaginative and who are already reading literature, including literature about illness and physician-patient relationships.” He added that as a physician, he is often asked to listen to his patients’ stories with empathy; in contrast, not once has he ever had to calculate the trajectory of a patient to be shot out of a cannon. - Jacob M. Appel, MD, Assistant Professor, Psychiatry, Medical Education, Director, Ethics Education in Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.theatlantic.com/letters/archive/2018/08/letter-literature-should-be-a-medical- school-admissions-requirement/566756/ Additional coverage: Health Throughfare https://www.healththoroughfare.com/news/medical-students-should-be-educated- in-a-more-compassionate-spirit/10743
Westfair – August 5 MediSprout App Offers Timely Care Without Waiting Room Angst— Ryan Deffenbaugh About 27 percent of a physician’s time goes to actual patients; the rest is spent doing paperwork, calling insurance companies and other administrative tasks. That level of paperwork can leave a doctor feeling burnt out. To solve this, Samant Virk founded MediSprout. MediSprout’s corner of the market could come from its ability to appeal directly to doctors. Rather than having a large group of doctors ready to see patients on demand, MediSprout’s focus is on providing a virtual option for patients to reach their doctors, and vice versa. The ability to connect patients directly to their doctor was important to Virk, who described seeing a growing world of “outsourced medicine.” MediSprout is already working with Mount Sinai Hospital. The Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center at Mount Sinai, uses MediSprout’s app to help track follow up care for complex IBD patients. The app has been used about 700 times since summer 2016 by the center, the hospital estimated in a case study. The hospital believes that interacting with patients through the app could cut down on unnecessary hospital visits. - The Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, Mount Sinai Hospital Learn more: https://westfaironline.com/105298/medisprout-focuses-new-tech-on-age-old-doctor-patient- relationship/
The Washington Post – August 6 Environmental Toxins Are Seen As Posing Risks During Pregnancy — Rachel Cernansky Leading up to and during pregnancy, women are told to avoid alcohol and cigarettes, to make sure they get enough folate and omega-3 fatty acids, and to get adequate sleep and exercise. Most are told little or nothing about reducing their exposure to chemicals despite evidence suggesting that ingredients in plastics, vehicle exhaust and cosmetics additives can have profound impacts on babies’ health. Philip Landrigan, MD, MSc, professor of pediatrics, environmental medicine and public health, and dean for global health at the Icahn School of Medicine at Mount Sinai, said, “For years and years, we’ve talked about alcohol, tobacco, and recreational drug use – limiting all those during pregnancy. However, in the last decade, ACOG has come to realize that lead, pesticides, PCBs, and mercury that are found in certain fish – that all of those pose a harm to the fetus in the womb and that it makes an awful lot of sense for women to minimize their exposure to those chemicals.” While chemicals are virtually impossible to avoid completely, people can reduce contact with some of the most harmful and common toxins. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.washingtonpost.com/national/health-science/environmental-toxins-are-seen-as- posing-risks-during-pregnancy/2018/08/03/770fab98-7643-11e8-9780-b1dd6a09b549_story.html? utm_term=.9764c11a6459
Newsmax Health – August 5 Women With Common Ovary Condition Often Feel Medical System Failed Them Many women with polycystic ovary syndrome feel they've been let down by a healthcare system that takes years to diagnose their condition, a new survey suggests. Researchers found that women with polycystic ovary syndrome, or PCOS, a common condition characterized by metabolic and fertility problems, were more likely than others to distrust their primary care physician's judgment and to feel that they weren't getting enough social support from healthcare providers. A contributor to delayed diagnoses may be primary care physicians’ lack of familiarity with the condition, not to mention the latest information on it, said Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease at the Mount Sinai Health System. The name, which is really a misnomer, doesn't help, Dr. Dunaif said. The bumps on the ovaries aren't cysts and the condition has symptoms that go far beyond the reproductive system, she explained. PCOS has also been linked to increased risks for diabetes, obesity and heart disease. Dr. Dunaif has a piece of advice for primary care physicians. "Menses are a vital sign," she said. "You should be asking women what their menstrual history is. It can be a sign that there is an endocrine disorder that needs to be diagnosed." – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://www.newsmax.com/health/health-news/women-polycystic-ovary-syndrome- pcos/2018/08/05/id/875574/ Additional coverage: Physician’s Weekly https://www.physiciansweekly.com/women-with-common-ovary/ Deccan Chronicle https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/040818/women-with- common-ovary-condition-often-feel-medical-system-failed-the.html
MedPage Today – August 3 ‘Not All About Genitalia:’ What We Heard This Week Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai and senior faculty of endocrinology at the Icahn School of Medicine at Mount Sinai, talks about provider assumptions that “sex change” operations are at the core of gender reassignment. - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/surgery/generalsurgery/74410
Healthline – August 3 Everything You Need To Know About Hepatitis A, B, C, D, and E — Stephanie Booth A liver that works well is vital to your health, and one of the biggest threats to it is an inflammatory condition known as hepatitis. Hepatitis A has been in the new a lot recently. From California to Tennessee, outbreaks are on the rise in the United States and around the globe. While HAV often passes on its own within a few months, and most people make a full recovery, it can be prevented with a simple vaccine shot. “Personally, I think it should be part of a general health exam,” said Douglas Dieterich, MD, director of the Institute for Liver Medicine at professor of liver disease at the Icahn School of Medicine at Mount Sinai. “No vaccine is 100 percent effective, but it’s as close as you can get.” - Douglas Dieterich, MD, Director, Institute of Liver Medicine, Professor, Liver Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/everything-you-need-to-know-about-hepatitis
Prevention – August 3 Ten Reasons You Always Seem To Catch A Cold — Anisa Arsenault If you feel like your winter is one long, drawn-out cold season, you’re certainly not alone. There are a number of things you could be doing that are upping your chances of getting sick, as well as passing on your germs to others. “The common cold is very transmissible,” said Benjamin Tweel, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “Its viruses, usually rhinoviruses, are spread both by touch and through the air – you can pick up someone’s sneeze just by breathing.” Dr. Tweel emphasizes the importance of hydration, whether you’re trying to prevent a cold or fight one off. While there isn’t much research proving that drinking extra fluid will help you beat a cold, dehydration weakens the immune system, making you more susceptible to colds. Staying adequately hydrated helps your body function at its best. - Benjamin C. Tweel, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/health/a22626961/common-cold-causes/
Allure Magazine – August 6 A Visual Guide To Identifying First-, Second-, and Third-Degree Burns — Macaela Mackenzie If you’ve ever experienced a sunburn or scalded yourself in the kitchen, you need to know some basic burn first aid – and when to see a doctor for your sunburn. “If you develop a sunburn, treat the skin from the outside in and the inside out,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. Immediately after you burn, he recommends using a cold milk compress to help bring down any swelling and soothe any pain. Add skim milk to a bowl with rice and soak a washcloth in it – then apply to your burn. “Proteins from the milk coat, calm, and soothe the skin,” Dr. Zeichner explained. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/what-burns-look-like-degrees-photo-guide
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 7, 2018 Date: Tuesday, August 07, 2018 2:45:00 PM Attachments: ATT00001.txt
In the News August 7, 2018
Orthopedics This Week – August 6 New Gene For Severity Of Rheumatoid Arthritis? — Elizabeth Hofheinz, MPH, MEd Researchers from the Icahn School of Medicine at Mount Sinai have identified a potential new therapeutic target for patients with rheumatoid arthritis. Their research was published in the Annals of the Rheumatic Diseases. Percio S. Gulko, MD, chief of the division of rheumatology and the Lillian and Henry M. Stratton professor of medicine and rheumatology at the Icahn School of Medicine at Mount Sinai was a senior author on the paper. “There have been major advances in the treatment of rheumatoid arthritis in the past 20 years, but disease remission still remains uncommon. Most drugs today target inflammation but often that is not enough to control the disease. At my laboratory we have been looking for alternative strategies. In this research, we have focused on understanding the regulation of disease severity and joint damage. Our discovery led us to synovial fibroblasts, cells inside the joint.” He concluded that, “Disease severity and joint damage are major predictors of outcome/prognosis in RA and therefore understanding their regulation is anticipated to generate new and perhaps better targets for treatment.” - Percio S. Gulko, MD, Chief, Division of Rheumatology, Lillian and Henry M. Stratton Professor, Medicine, Rheumatology, Icahn School of Medicine at Mount Sinai Learn more: https://ryortho.com/breaking/new-gene-for-severity-of-rheumatoid-arthritis/
MedPage Today – August 6 Cardiovascular Risks Elevated In Transgender Women—Shannon Firth The use of estrogen therapy in transgender women appears to put them at increased risk for cardiac events, a review of the available scientific literature found. Among transgender men (those born as female but identifying as male), there appeared to be no increase in stroke or VTE, while the risk of MI is still unknown, as reported in Reviews in Endocrine and Metabolic Disorders. Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai and senior faculty of endocrinology at the Icahn School of Medicine at Mount Sinai, said that the review “accentuates areas where we need more research, and it makes us more confident that even though there are some risks to hormone therapy, they’re not enormous.” He said that for transgender men, testosterone therapy remains "relatively safe," but that for transgender women, there's a risk of blood clotting with certain estrogen preparations. "All we seem to know is what we've known for some decades. Ethinyl estradiol is bad and estrogen, in general, seems to increase blood clot risk slightly," Dr. Safer said. "The risks that are there are exactly the risks that have been suspected ... they're not enormous, and they will not change most patients' choices regarding taking hormones." - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/venousthrombosis/74425
Patient Power – July 11 Hodgkin Lymphoma Research Updates From Dr. Joshua Brody What’s new for those living with Hodgkin lymphoma? Although today’s standard of care cures some, the ever-evolving field of cancer research is finding innovative approaches to benefit a greater number of patients. Joshua Brody, MD, assistant professor of medicine, hematology and medical oncology, director of the Lymphoma Immunotherapy Program at the Icahn School of Medicine at Mount Sinai, discusses recent advances in immunotherapy, anti-body drug conjugates, and targeted and combination therapies for Hodgkin lymphoma patients. Dr. Brody also shares results from the ECHELON-1 trial, the rate of progression-free survival, and how the side effect profile compares to standard therapies. - Joshua Brody, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Director, Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.patientpower.info/video/hodgkin-lymphoma-research-updates-from-dr- joshua-brody
Patient Power – July 10 Non-Hodgkin Lymphoma Updates From An Expert Joshua Brody, MD, assistant professor of medicine, hematology and medical oncology, director of the Lymphoma Immunotherapy Program at the Icahn School of Medicine at Mount Sinai, joined Patient Power to provide an update in non-Hodgkin lymphoma research. Have new avenues in treatment been created? Dr. Brody shares data collected on novel agents like monoclonal antibodies, anti-body drug conjugate and immunotherapy approaches for those living with non-Hodgkin lymphoma. How can patients with more aggressive conditions access promising new therapies? Dr. Brody also discusses unprecedented results from clinical trials on CAR T-cell therapy for diffuse large B-cell lymphoma, recent FDA approvals, and where research is headed next. - Joshua Brody, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Director, Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.patientpower.info/video/non-hodgkin-lymphoma-updates-from-an-expert
OncLive – August 3 Peer Exchange: Timing Of Second-Line Therapy In Follicular Lymphoma Experts discuss relapsed follicular lymphoma and the decision regarding when to treat the next patient after they’ve already had a therapy. They have these criteria that have been written down for frontline with normal indications for treatment – bulky disease, cytopenias, pleural infusions, symptoms. Joshua Bordy, MD, assistant professor of medicine, hematology and medical oncology and director of the Lymphoma Immunotherapy Program at the Icahn School of Medicine at Mount Sinai said, “It’s rare that they’ll have better kinetics on their recurrence than they had in their initial presentation. If they quickly progressed needing more therapy the first time around, you can see that it’s going to happen again.” - Joshua Brody, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Director, Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.onclive.com/peer-exchange/fl-evolving-research/timing-of-second-line-therapy- in-follicular-lymphoma?sp=
CNN – August 6 Beyonce, Serena Williams Bring Attention To Risks Of Childbirth For Black Women — Jacqueline Howard Every day, about 830 women around the globe die from preventable causes related to pregnancy and childbirth, according to the World Health Organization. In the United States, about 700 women die each year as a result of pregnancy and delivery complications, and the risk of pregnancy-related death among black women is three to four times higher than among white women, according to the Centers for Disease Control and Prevention. “Black women often suffer more of these than do white women, in particularly the hypertensive diseases. So chronic hypertensions, preeclampsia during pregnancy are more common among black women than white women,” said Elizabeth A. Howell, MD, MPP, associate dean of academic development and director of the Blavatnik Family Women’s Health Research Institute at the Icahn School of Medicine at Mount Sinai. Beyonce’s and Serena Williams’ pregnancy stories have garnered much attention among men and women alike, with several people tweeting about the women’s bravery in opening up. - Elizabeth A. Howell, MD, MPP, Associate Dean, Academic Development, Director, The Blavatnik Family Women’s Health Research Institute, Professor, Population Health Science and Policy, Psychiatry, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnn.com/2018/08/06/health/beyonce-vogue-pregnancy-complication- bn/index.html
Reader’s Digest – August 6 The 12 Worst Places On Your Body To Get A Sunburn — Amanda Etkind Basically, a sunburn anywhere is a terrible place. But these are the areas we tend to overlook – and can lead to extremely painful results. “The skin on the tops of the your ears is very delicate making it more susceptible to sunburn,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. In addition to being a delicate area, the tops of the ears tend to be overlooked when applying sunscreen, he said. Stick to applying a high-level of SPF, and again, wear a wide-brimmed hat to ensure it’s not getting any exposure whatsoever. The American Academy of Dermatology estimates one in five Americans will get skin cancer in their lifetime – and the most common spots are the face and head. According to Dr. Zeichner, “consumers apply less than 50 percent of the amount of sunscreen that they should be using.” That’s why he suggests using the highest SPF value possible. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.rd.com/health/wellness/worst-places-on-body-get-sunburn/
Prevention – August 6 7 Best Neck Creams For Firmer, Younger-Looking Skin— Jessica Migala Neck creams are formulated to firm and tighten, even out skin tone, and re-texturize crepey skin. You can also streamline the process and bring your favorite facial creams down to your neck. Retinoids are one of the best anti-agers for your face – and the same goes for you neck. “Retinoids can help prevent fine line and wrinkles and improve skin texture,” said Meera Sivendran, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. She recommends using Differin on your neck too, which is the only OTC retinoid available that’s prescription strength. - Meera Sivendran, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/beauty/skin-care/g22653212/best-neck-creams/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 8, 2018 Date: Wednesday, August 08, 2018 12:43:31 PM Attachments: ATT00001.txt
In the News August 8, 2018
Health Tech Magazine – August 7 Mount Sinai Taps A Strong IT Support System For EHR— Melissa Delaney Preparing infrastructure for an electronic health record (EHR) rollout is always complex, but as Kristin Myers, senior vice president of information technology at the Mount Sinai Health System, embarks on her fifth Epic hospital installation, she knows the drill. Myers undertook her first Epic implementation in 2006. After the health system’s merger with Continuum Health Partners in 2013, she has steadily added to her list of projects, including two hospitals that went live this March. Next up is Mount Sinai Brooklyn. To achieve the benefits of EHRs – better care continuity, shortened hospital stays, reduced admissions – the IT supporting the system must be stable and have near 100 percent uptime. “If you deploy an EHR on an existing infrastructure, you are placing your transformation project at risk,” she said. The goal, Myers said, is for as much of the infrastructure as possible to meet Mount Sinai’s standards. “It’s really important because that’s how there is a standard of care that is consistent throughout the health system, where physicians can use the system at multiple hospitals, and from a technology perspective, you are able to leverage a centralized support model.” - Kristin Myers, Senior Vice President, Information Technology, Mount Sinai Health System Learn more: https://healthtechmagazine.net/article/2018/08/complementary-upgrades-help-hospitals-get- most-out-ehr-deployments
Proto Magazine – August 2 100 Year Shadow Influenza viruses cause epidemics in the United States every year, year after year. To overcome the problem of mismatched vaccines, some researchers are looked at the “conserved” parts of the flu virus – the ones that don’t generally change. One possible solution is to redirect the immune system’s attention to the head of the stalk, which doesn’t undergo mutations, said Peter Palese, PhD, professor and chair of microbiology at the Icahn School of Medicine at Mount Sinai. Dr. Palese and his colleagues created a structure called a chimeric hemagglutinin (cHA), which tricked the immune system into making protective antibodies against the stalk as well as the conserved neuraminidase. In animal studies, repeated inoculations with a cHA-based vaccine persuaded the immune system to ignore the strange head and instead direct antibodies against the stalk and the neuraminidase, said Florian Krammer, PhD, associate professor of microbiology at the Icahn School of Medicine at Mount Sinai, Dr. Palese’s colleague at Mount Sinai and a frequent co-investigator. In theory, this kind of universal vaccine would train the immune system to recognize a portion of the virus that remains unchanged in all forms of influenza— both seasonal flu and any new, particularly virulent strains. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai - Florian Krammer, PhD, Associate Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: http://protomag.com/articles/100-year-shadow? utm_medium=etoc&utm_term=july2018&utm_source=article-image-100-year- shadow&utm_campaign=protomag-enews
Drug Target Review – August 7 ‘Drug Cocktails’ Could Strengthen Targeted Cancer Therapies Researchers have identified that certain drugs taken in combination, ‘drug cocktails,’ help therapies to target and attack cancer more efficiently. The team for the Icahn School of Medicine at Mount Sinai discovered that side effects lessened when using certain ‘drug cocktails.’ “Targeted therapies have revolutionized cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy and lower side effects compared to chemotherapy,” said Tirtha K. Das, MD, assistant professor of cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai. “Our work addresses the central question faced by physicians who treat cancer patients: how do targeted therapies both promote resistance in cancer cells and evoke toxic side effects in patients?” The drug cocktails developed by the researchers are an advanced method of pushing current efforts using targeted therapies to treat patients. The method of attacking cancer growth from more than one area could increase the chance of success in more patients. - Tirtha K. Das, MD, Assistant Professor, Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai Learn more: https://www.drugtargetreview.com/news/34066/drug-cocktails-cancer/
Relias Media – August 1 Shared Decision-Making Is ‘Moral Imperative’ Despite Challenges In ED Shared decision-making is an important concept for patient autonomy, but how does it play out in the unique ED setting? “There is a moral imperative to perform shared decision-making in the ED setting when the appropriate preconditions are met,” according to Marc Probst, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai. Dr. Probst is the primary author of a recent paper on this topic. “The emergency physician has medical expertise in diagnostic testing and therapeutic interventions. Patients know their goals and values best,” says Dr. Probst. Shared decision- making uses these two perspectives to arrive at a mutually agreed-upon plan of care. - Marc A. Probst, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.reliasmedia.com/articles/143029-shared-decision-making-is-moral-imperative- despite-challenges-in-ed
San Francisco Chronicle – August 8 What Elephants’ Unique Brain Structures Suggest About Their Mental Abilities — Bob Jacobs Researchers at the University of Witwatersrand in South Africa obtained permission in 2009 to extract and preserve the brains of three African elephants that were scheduled to be culled as part of a larger population management strategy. We have thus learned more about the elephant brain in the last 10 years than ever before. The research shared here was conducted at Colorado College in 2009-2011 in cooperation with Patrick Hof, MD, professor of neuroscience at the Icahn School of Medicine at Mount Sinai and Chet Sherwood, a Columbia University anthropologist. The goal was to explore the shapes and sizes of neurons in the elephant cortex. The brains of all species are unique. Indeed, even the brains of individuals within a given species are unique. However, the special morphology of elephant cortical neurons reminds us that there is certainly more than one way to wire an intelligent brain. - Patrick R. Hof, MD, Professor, Neuroscience, Ophthalmology, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.sfchronicle.com/news/article/What-elephants-unique-brain-structures-suggest- 13140340.php
The Atlantic – August 7 Fad Diets Won’t Save You From Acne — Angela Lashbrook A small 2016 study found that 46 of the study’s 49 dermatologic patients believed that diet affects acne, with greasy foods at the No. 1 suspected culprit. The American Academy of Dermatology doesn’t currently recommend diet changes to manage acne, citing lack of sufficient data. Abigail Rapaport, MS, RD, senior dietician at The Mount Sinai Hospital said that, “Nutrition studies are hard to research in general, most of the research is on teens, and acne can be multifactorial, so you can’t say it’s only from dairy.” So while the connection between milk and acne isn’t a myth, a lot more research is needed to confidently tell acne sufferers to give up lattes. - Abigail Rapaport, MS, RD, Senior Dietician, Ketogenic Diet Specialist, Mount Sinai Hospital Learn more: https://www.theatlantic.com/health/archive/2018/08/acne-diet-pimples/566975/
Becker’s Hospital Review – July 26 Rising Stars: 90 Healthcare Leaders Under 40 Becker’s Healthcare has honored 90 healthcare leaders under 40 years old as rising stars in the industry. Individuals on this list have achieved executive positions at hospitals and health systems across the country, founded health IT companies and reached prominence within their organizations. Several are entrepreneurs and thought leaders in advancing patient outcomes and care management. Among those is Anne Dickerson, chief of staff for Mount Sinai Doctor Faculty Practice. Ms. Dickerson is responsible for coordinating operational and strategic initiatives and the flow of information for the Faculty Practice. She leads initiatives focused on space, patient access, patient and staff experience, quality and data management for 2,500 Icahn School of Medicine physicians based on and around seven hospital campuses. - Anne Dickerson, Chief of Staff, Mount Sinai Doctors Faculty Practice, Mount Sinai Health System Learn more: https://www.beckershospitalreview.com/lists/rising-stars-88-healthcare-leaders-under- 40.html
HealthiNation – July 20 A Surgeon To Patients: Stop Believing These Five Breast Cancer Surgery Myths After learning that you or a loved one has been diagnosed with breast cancer, it’s normal to feel a rollercoaster of emotions, such as confusion, worry, and fear, to name a few. In order to get the best breast cancer treatment available, it’s critical to not let these myths stand in the way of getting closer to curing or preventing breast cancer. “It’s always important for us to clear up these myths so that patients know the correct information,” said Jaime Alberty, MD, surgical breast oncologist at the Dubin Breast Center of the Tisch Cancer Institute at The Mount Sinai Hospital. Dr. Alberty debunks some of the most common myths about breast cancer surgery. - J. Jaime Alberty-Oller, MD, Assistant Professor, Surgery, Icahn School of Medicine at Mount Sinai, Surgical Breast Oncologist, The Dubin Breast Center, Tisch Cancer Institute, Mount Sinai Hospital Learn more https://www.healthination.com/health/breast-cancer-surgery-myths
Healthline – August 7 Why ‘Clean Eating’ Isn’t Going To Clear Up Your Skin — Julie Ries Having healthy skin isn’t all about what you eat. And supplements and vitamins aren’t necessarily the answer either. As a result of this misconception, more people are trying elimination diets — such as veganism, the Keto diet, or even a cleanse — in an effort to improve their skin. Many dermatologists advise against this, though, as elimination diets can cause people to miss out on essential vitamins, minerals, and amino acids. In fact, previous studies have indicated that vitamin deficiencies adversely affect the growth of your hair, skin, and nails. “Protein and vitamin B-12 levels are hard to maintain on a strict vegan diet,” said Janet Prystowsky, MD, PhD, associate clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. “Protein deficiency will weaken your skin and other body tissues. B-12 deficiency will cause anemia and neurological problems.” Additionally, those who become deficient in vitamin C may notice bruising. A vitamin D deficiency may cause painful rashes, Dr. Prystowsky added. - Janet H. Prystowsky, MD, PhD, Associate Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/clean-eating-isnt-going-to-clear-up-your-skin
Prevention – August 6 Six Herpes Symptoms In Women That You Shouldn’t Ignore— Cassie Shortsleeve Most people who have herpes simplex virus don’t show any symptoms and have not been diagnosed with herpes, according to the Centers for Disease Control and Prevention. And the virus is extraordinarily common. “About 60 to 70 percent of the population is positive for herpes simplex virus type 1, herpes simplex virus type 2, or both,” said Eric Ganz, MD, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. Herpes is diagnosed either by a sample of a sore itself or a blood test that IDs antibodies. - Eric M. Ganz, MD, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/health/health-conditions/a22652270/herpes-symptoms/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 9, 2018 Date: Thursday, August 09, 2018 1:57:08 PM Attachments: ATT00001.txt
In the News August 9, 2018
Forbes – August 9 How A Supercomputer Named Dr. Crusher Perfected Cancer Treatments For 21 Patients – Arlene Weintraub Samir Parekh, MBBS, associate professor of oncological sciences, medicine, hematology and medical oncology and director of translational research in myeloma at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and his colleagues wanted to change the treatment paradigm in multiple myeloma. So they developed a system that uses artificial intelligence to match up multiple myeloma patients with drugs that are already on the market to treat other cancers. They tried the resulting recommendations in a group of 21 patients with treatment-resistant multiple myeloma and got positive results in all but five – a response rate that’s so high Dr. Parekh believes the idea could be extended to many other cancers. “The response was quite amazing, considering this was a challenging population that had pretty much failed every treatment out there,” said Dr. Parekh. The study was published in the journal JCO Precision Oncology. - Samir Parekh, MBBS, Associate Professor, Oncological Sciences, Medicine, Hematology and Medical Oncology, Director, Translational Research in Myeloma, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.forbes.com/sites/arleneweintraub/2018/08/09/how-a-supercomputer-named-dr- crusher-perfected-cancer-treatments-for-21-patients/#1dd1c382581c Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-08-rna-dna-sequencing-platform-thousands- drugs.html R&D Magazine https://www.rdmag.com/news/2018/08/novel-rna-dna-sequencing-platform-matches- thousands-drugs-late-stage-cancer-patients Genetic Engineering & Biotechnology News https://www.genengnews.com/gen-news-highlights/dna- and-rna-sequencing-technique-offers-hope-to-drug-resistant-multiple-myeloma-patients/81256117 eCancer News https://ecancer.org/news/14553-new-rna---dna-sequencing-platform-matches-thousands- of-drugs-to-late-stage-cancer-patients.php
Long Island Herald – August 8 South Nassau Receives Top Awards In Women’s Health — Christina Daly South Nassau Communities Hospital has been named a 2018 five-star recipient for all four women’s care cohorts as well as the Gynecologic Surgery Excellence Award by Healthgrades, a leading online resource for comprehensive information about physicians and hospitals. Additionally, South Nassau is the only hospital in New York State to achieve five Healthgrades awards in 2018 in women’s health services. “The awards are a direct result of our multi-disciplinary healthcare team of top-notch physicians and nurses that utilize the latest medical technologies and treatments to deliver high-quality healthcare tailored to the specific needs of women,” said Alan Garely, clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and chairman of obstetrics and gynecology at South Nassau. - Alan Garely, MD, Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: http://liherald.com/stories/south-nassau-receives-top-awards-in-womens-health,105921
Crain’s Health Pulse – August 9 Mount Sinai’s Dubin Breast Center Plans $1.8M Expansion — Robin Schatz The Mount Sinai Hospital is seeking state approval to renovate and expand its Dubin Breast Center to meet growing demand for its screening and treatment services. The 2,650-square-foot space, located on the basement level of the Klingenstein Pavilion on its main campus, will be expanded to 4,250 square feet. The hospital plans to add five infusion stations, bringing its total to 12. It also plans to add a nurse station, a clinical coordinator work area, offices, a staff room and other support spaces. Dubin provides a multidisciplinary, comprehensive approach to breast cancer screening and treatment. Construction, which will be funded by the hospital’s cash equity, is estimated to take three and a half months. - Dubin Breast Center Learn more: http://www.crainsnewyork.com/article/20180809/PULSE/180809898/capsule-pharmacy- raises-50m-to-prep-for-national-rollout
Markets Insider – August 9 Sleep Technology Startup Eight Announces New Members To World-Class Scientific Advisory Board Eight, the technology company focused on improving the way we sleep – announced the expansion of its world-class Scientific Advisory Board (SAB), which included the country’s top minds at the forefront of sleep research from Harvard, Stanford, Mount Sinai, Yale and University of Pennsylvania. The new SAB members will serve as strategic partners in guiding the director of Eight’s growing research and scientific programs. The new members join David Rapoport, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai, who has advised Eight since 2014. Dr. Rapoport has a long-standing interest in the physiology of sleep disordered breathing and has accumulated a body of research on the topic. - David M. Rapoport, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://markets.businessinsider.com/news/stocks/sleep-technology-startup-eight-announces- new-members-to-world-class-scientific-advisory-board-1027445981 Additional coverage: Silicon Valley https://siliconalley.com/tech-news-news-from-pr-newswire/? rkey=20180809NY74955&filter=4964
MD Alert – August 8 Preop Antivirals May Curb Early Recurrence of HBV-Related HCC — Marilynn Larkin In patients undergoing partial hepatectomy for hepatitis-B virus (HBV)-related hepatocellular carcinoma (HCC), antiviral therapy (AVT) given more than 90 days before surgery is associated with fewer incidences of microvascular invasion and early tumor recurrence, researchers say. Thomas Schiano, MD, medical director of adult liver transplantation and director of clinical hepatology and intestinal transplantation at the Recanati/Miller Transplantation Institute at The Mount Sinai Hospital said, “This study helps confirm the many benefits of adequate hepatitis B virus (HBV) treatment; decreasing risk for liver cancer is one of them as well as preventing the development of cirrhosis.” He added, “With the wonderful, highly effective and well-tolerated medications in our armamentarium, there is no downside to treating all patients having HBV.” - Thomas D. Schiano, MD, Professor, Medicine, Liver Diseases, Icahn School of Medicine at Mount Sinai, Medical Director, Adult Liver Transplantation, Director, Clinical Hepatology and Intestinal Transplantation, The Recanati/Miller Transplantation Institute, The Mount Sinai Hospital Learn more: http://www.mdalert.com/news/article/preop-antivirals-may-curb-early-recurrence-of-hbv- related-hcc Additional coverage: Managed Health Care https://www.managedhealthcareconnect.com/content/preop-antivirals-may-curb- early-recurrence-hbv-related-hcc?page=6,0
U.S. News & World Report – July 27 Your Guide To Exercising With Osteoporosis — K. Aleisha Fetters If you have osteopenia or osteoporosis, you may be concerned that putting stress on your bones through exercise could lead to fractures. But with the right strategy, working out is the exact solution to help prevent those with injuries. “You want to challenge yourself, but not to the point where you’re putting yourself at risk for injuries,” said Leesa Galatz, MD, professor and system chair of the department of orthopedics at the Icahn School of Medicine at Mount Sinai. “If you have localized pain with exercise, especially if it starts hurting when you’re not exercising, you should definitely have it evaluated,” Dr. Galatz added. - Leesa Galatz, MD, Professor, System Chair, Orthopedics, Icahn School of Medicine at Mount Sinai Learn more: https://health.usnews.com/wellness/fitness/articles/2018-07-27/your-guide-to-exercising- with-osteoporosis
CBS New York – August 8 Carrie Underwood Announces She’s Pregnant Days After Controversial Remarks On Fertility — Dave Carlin Country superstar Carrie Underwood announced she’s pregnant with her second child, with her reveal coming just two days after comments she made about later-in-life pregnancies. Underwood said, “I’m 35, so we may have missed our chance to have a big family.” The quote has made some fans wondering if she’s out of touch with statistics showing that more women than ever are having children in their forties, or even older. Alan Copperman, MD, director of the division of reproductive endocrinology and infertility and vice chairman of the department of obstetrics, gynecology and reproductive science at the Mount Sinai Health System, said not only does he support what Carrie Underwood is saying after the age of 34, but he’s also glad it’s starting a conversation. “The statement that she made was actually accurate,” said Dr. Copperman. “She raised awareness that if you want two, three, or four children and you’re starting at the age of 35 you’re really going to have some challenges meeting your life choices.” - Alan B. Copperman, MD, Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director, Division of Reproductive Endocrinology and Infertility, Vice Chairman, Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System Learn more: https://newyork.cbslocal.com/2018/08/08/carrie-underwood-announces-shes-pregnant-days- after-controversial-remarks-on-fertility/
The Cut – August 8 My Leg Hurts, Do I Have Necrotizing Fasciitis? — Katie Heaney Leg pain is one of the symptoms of necrotizing fasciitis, but the context is super important – one’s legs can cramp and hurt from all sorts of things, but if yours hurts beyond what might be expected given your activity or injury, that’s when you might want to worry, said Ageliki Vouyouka, MD, associate professor of surgery and radiology at the Icahn School of Medicine at Mount Sinai. It’s also unlikely that an otherwise healthy person can contract necrotizing fasciitis. “Healthy people usually cannot get it,” said Dr. Vouyouka. “It has to be someone who has some sort of immunosuppression – someone who has cancer, or is malnourished, or is diabetic. There are a few circumstances of people contracting it under significant stress, because that also causes immunosuppression, but I’ve never seen that.” In cases of necrotizing fasciitis, redness and pain will likely also be accompanied by fever, fatigue, and clear drainage at the site of the injury, Dr. Vouyouka added. So if you don’t have any of that, and you recently exercised in a way that could plausibly cause leg pain, or you’ve just got a little scratch that hurts a typical amount, and you’ve got a healthy immune system, you’re probably okay. - Ageliki G. Vouyouka, MD, Associate Professor, Surgery, Radiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.thecut.com/2018/08/my-leg-hurts-do-i-have-necrotizing-fasciitis.html
Prevention – August 8 Does Bone Broth Actually Have Any Health Benefits? — Macaela Mackenzie Bone broth, a stock made from simmering animal bones makes a lot of big claims: it promises to give you youthful skin, protect your joints, boost your metabolism, improve your gut health, and be a good source of nutrients. As of right now, all the hype around bone broth is totally unproven – and the experts are skeptical about the benefits. Many proponents of bone broth point to the benefits of collagen – a key part of keeping skin hydrated and firm. But there’s just one tiny problem: “Just because you consume collagen doesn’t mean your body will use its amino acid particles to plump and protect your skin,” said Perri Halperin, MS, RD, dietician at The Mount Sinai Hospital. “Science has yet to prove that anything we eat or drink can make the liver more efficient at detoxifying,” Halperin explains. “One thing that can be helpful, however, is getting enough fluid, and bone broth is a source of fluid.” So technically, yes, bone broth can help you detox—“but that isn’t bone broth magic,” Halperin says, “it’s just simple hydration.” - Perri Halperin, MS, RD, Dietician, The Mount Sinai Hospital Learn more: https://www.prevention.com/food-nutrition/a22668149/bone-broth-benefits/
Pulse Nigeria – August 9 Four Migraine Treatments That Might Actually Work About 12 percent of Americans get migraines, according to the U.S. National Library of Medicine. They disproportionately affect women, who are three times more likely than men to get migraines. To help calm your throbbing head, try these migraine helpers, recommended by Lauren Natbony, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai. Migraine sufferers tend to have lower levels of magnesium, a vitamin that can inhibit ache-causing brain signals. To slash frequency and severity of head pain, pop a 400- to 500-milligram supplement daily (clear it with your doctor first). Patience is a virtue with this OTC aid-it could take up to six weeks to notice a change. - Lauren Natbony, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.pulse.ng/lifestyle/womens-health/4-migraine-treatments-that-might-actually- work-id8705189.html
Prevention – August 8 How To Prevent And Treat That Awful Rash You Get From Chafing — Richard Laliberte Chafing is a rash-like inflammation that happens when moist skin rubs against other moist skin or clothing. It’s especially common in skin folds where sweat becomes trapped, such as the groin, the armpits, and under the breasts, and after walking or other forms of exercise. And because raw, moisture- laden skin invited microbial overgrowth, a skin infection can follow. “Abrasion from moisture and friction makes microscopic cuts in the skin, and salt from sweat can exacerbate the irritation,” said Cameron Rokhsar, MD, associate clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. Moisture-trapping cotton is not your friend when it comes to chafing – instead, choose synthetic fabrics like polyester or Lycra, which aren’t as absorbent. - Cameron K. Rokhsar, MD, Associate Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/fitness/fitness-tips/a22665264/skin-chafing-treatment/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 10, 2018 Date: Friday, August 10, 2018 12:48:18 PM Attachments: ATT00001.txt
In the News August 10, 2018
DDN News –August 9 A New Bladder Cancer Biomarker — Mel J. Yeates A potential new target for treatment has been identified in a specific form of bladder cancer, Mount Sinai researchers report. The research team at Mount Sinai identified two microRNA activity-based biomarkers that can provide insights regarding which patients with p53-like bladder cancer may have better or worse prognoses. Our method for quantifying microRNA activity has been validated in multiple subtypes of breast cancer; I am glad to see that the method is validated in bladder cancer as well. MicroRNAs are promising biomarkers and therapeutics. I hope our method can have a broader impact on selecting best microRNAs for biomarker and therapeutic development,” notes Eunjee Lee, MD, senior scientist in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and director of integrative networks at Sema4, a patient-centered predictive health company and Mount Sinai venture. - Eunjee Lee, PhD, Senior Scientists, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Director, Integrative Networks, Sema4 - Jun Zhu, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Head, Data Science, Sema4 - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Icahn School of Medicine at Mount Sinai Learn more: http://www.ddn-news.com/index.php?pg=77&articleid=12663
Business Insider – August 10 The Designers Who Created Projects For Nike And Beyonce Teamed Up With Mount Sinai To Build A Futuristic, New Clinic — And It's Reimagining How Healthcare Is Delivered — Charlotte Hu Welcome to the clinic of the future. At least that's how David Stark, MD,an assistant professor of health system design and global health at the Icahn School of Medicine at Mount Sinai and medical director of the institute for next generation health care, refers to Lab100, which sits in New York City's Upper East Side. Lab100 gives patients a comprehensive health risk assessment and biometric screening. The goal is to empower patients to track their health over time and to learn how their behavior and lifestyle are impacting their health in a very tangible way. "This comes from the notion that health is more than just the absence of disease, it's a whole continuum," Dr. Stark told Business Insider. - David Stark, MD, Assistant Professor, Health System Design and Global Health, Icahn School of Medicine at Mount Sinai, Medical Director, Institute for Next Generation Health Care Learn more: https://www.businessinsider.com/inside-mount-sinais-lab100s-clinic-of-the-future-2018-8
Innovate Long Island – August 9 South Nassau, Mount Sinai Eye Internal-Med Residencies — Gregory Zeller Thirty physicians will receive specialty training in a new Internal Medicine Residency Program at South Nassau Communities Hospital. South Nassau has received approval from the Accreditation Council for Graduate Medical Education for the new residency program, which kicked off last month and is being run in conjunction with the Mount Sinai Health System. It also sponsors a Council on Podiatric Medical Education – accredited podiatry program – all of which means the new Mount Sinai-affiliated Internal Medicine Residency Program is in fairly elite company, according to Michael Leitman, MD, dean of graduate medical education and professor of surgery and medical education at the Icahn School of Medicine at Mount Sinai. “This will be the first medical school-sponsored program of its kind on the South Shore of Long Island,” Dr. Leitman said. “Residents will have exceptional educational, clinical and research opportunities, and it is our hope that graduates of this program will remain in local practices to care for our community.” - I. Michael Leitman, MD, Dean, Graduate Medical Education, Professor, Surgery, Icahn School of Medicien at Mount Sinai Learn more: http://www.innovateli.com/south-nassau-mount-sinai-eye-internal-med-residencies/
MedPage Today – August 9 OncoBreak: Cancer-Causing Tattoos; TNBC Genes ID’d; Dental Care Predicts Mortality? — Ian Ingram Researchers at Mount Sinai developed an RNA/DNA sequencing platform that identifies viable treatment strategies using off-label, FDA-approved agents for late-stage multiple myeloma patients who have otherwise run out of options. - Samir Parekh, MBBS, Associate Professor, Oncological Sciences, Medicine, Hematology and Medical Oncology, Director, Translational Research in Myeloma, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/hematologyoncology/othercancers/74496 Additional coverage: tctMD – August 9 CKD Patients With Left Main Disease See Similar Outcomes At Three Years After PCI vs CABG: EXCEL — Caitlin E. Cox Chronic kidney disease (CKD) in patients being treated for left main disease is linked to poorer outcomes, with similar results offered by both CABG surgery and PCI over the long term, according to a pre- specified subgroup analysis from the EXCEL trial. But researchers also found that PCI offers up-front advantages for patients with CKD: fewer instances of acute renal failure, less blessing, fewer blood transfusions, and a reduced risk of death, MI, and stroke in the first 30 days. Gennaro Giustino, MD, resident physician at the Zena and Michael A. Wiener Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, lead author of the new analysis, said it’s well known that patients with CKD are generally at higher risk of experiencing adverse effects after revascularization, whether PCI or CABG. "They have a lot of comorbidities that place them at risk for many types of adverse events, including bleeding, vascular complications, stroke, and mortality," he explained. "At the same time, chronic kidney disease in itself is a strong risk factor for worsening renal function [requiring dialysis], and obviously that is going to be a very important determinant for future prognosis." - Gennaro Giustino, MD, Resident Physician, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/ckd-patients-left-main-disease-see-similar-outcomes-3-years- after-pci-vs-cabg-excel
AAFP News – August 8 Residents Tackle Tough Issues To Ensure Good Patient Care — Sheri Porter Family medicine residents descended on the downtown convention center August 2-4 for the annual AAFP National Conference of Family Medicine Residents and Medical Students. A good chunk of the residents participated in the 2018 National Congress of Family Medicine Residents, where they crafted and discussed more than two dozen resolutions aimed at making patients healthier and ensuring physicians are equipped to do their jobs. Jiana Menendez, MD, MPH, a resident of family medicine at Mount Sinai Downtown said, “In my work in New York City, I’ve worked in a variety of homeless shelters where the lack of access to these medical necessities has become immediately apparent. In one clinic in particular, I was working with a patient who kept coming in requesting socks. I finally realized that the reason she required so many socks was that she was using them as menstrual products.” During congress, residents adopted the resolution asking the AAFP to recognize the problem and to encourage chapters to advocate for access to unlimited free menstrual hygiene products including pads, tampons, and clean underwear. - Jiana S. Menendez, MD, MPH, Resident, Family Medicine, Mount Sinai Downtown Learn more: https://www.aafp.org/news/education-professional-development/20180808nc- rescongress.html
Prevention – August 9 Six Ways Meditation Benefits Every Part Of Your Body— Macaela Mackenzie If you’ve ever spent a few minutes meditating at the end of yoga class, you know that trying to slow down your thoughts is a bit trickier than it looks. But practicing mediation trains your mind to focus your awareness on the present, which can help you achieve that coveted Zen. This state of calmness doesn’t just feel good—it’s actually good for your health, too. Even mainstream medicine is starting to acknowledge the ancient practice as research surrounding its benefits grows. There’s also evidence that a mindfulness-based meditation gives you a brain boost. In fact, a study published in Psychological Science concluded that two weeks of mindfulness training improved the GRE reading comprehension scores of participants compared to a control group. “They showed that mindfulness meditation would decrease mind wandering and improve cognitive performance,” explained Mickie Brown, RN, clinical manager for education, mindfulness and patient wellbeing at Mount Sinai Selikoff Centers for Occupational Health, who was not involved with the study. - Mickie Brown, RN, Clinical Manager, Education, Mindfulness, Patient Wellbeing, Mount Sinai Selikoff Centers for Occupational Health Learn more: https://www.prevention.com/health/a22679621/health-benefits-of-meditation/
Experience Life –July/August 2018 How Do I Get Rid of Leg Cramps When Working Out? — Jon Spayde If a sudden, involuntary muscle contraction strikes while you’re exercising, just take a break, advises Alexis Colvin, MD, associate professor of sports medicine and orthopedics at the Icahn School of Medicine at Mount Sinai. “Then try some gentle stretching, or use a roller on the muscle. Keep in mind that a cramp can sometimes be helpful. It can indicate that you’re using a muscle in a new and unfamiliar way, as in a challenging yoga pose. If this is the case, try relaxing into the cramp before giving up altogether. But if you’re experiencing frequent cramps for no obvious reason,” - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: https://experiencelife.com/article/how-do-i-get-rid-of-leg-cramps-when-working-out/
Strategist – August 9 The Best Skin-Care Products for Redness and Rosacea, According to Dermatologists — Lori Keong Dealing with red, reactive skin and rosacea – a chronic condition where skin is overly sensitive, often with visible blood vessels and raised bumps on the face – usually means tiptoeing around anything that could trigger a flare-up. The problem is that virtually “anything that makes the face flush can cause a rosacea flare,” says Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. Common triggers include stress, extreme temperatures, spicy foods, fragrance and alcohol in skin care, and alcoholic drinks (especially wine), says dermatologist Debra Jaliman, MD, assistant professor of dermatology at Mount Sinai’s Icahn School of Medicine. Even hot showers and skin-care acids can worsen symptoms. But there are ways to tame outbreaks and lessen their effects Drs. Zeichner and Jaliman suggest the products that might calm and camouflage inflamed skin, from creams and cleansers to tinted primers and sunscreen. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: http://nymag.com/strategist/article/best-skincare-products-for-redness-and-rosacea.html
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 13, 2018 Date: Monday, August 13, 2018 12:46:54 PM Attachments: ATT00001.txt
In the News August 13, 2018
The New York Times – August 13 Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA — Gina Kolata With a sophisticated new algorithm, scientists have found a way to forecast an individual’s risks for five deadly diseases. By surveying changes in DNA at 6.6 million places in the human genome, investigators were able to identify many more people at risk than do the usual genetic tests, which take into account very few genes. People may need genetic counseling before and after getting these sorts of risk scores, noted Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai and founder and CEO of Sema4, Patients may not appreciate the consequences of learning they have a high likelihood of having a heart attack or breast cancer or one of the other diseases the test assesses. “Do people really understand that once you learn something you cannot unlearn it?” said Dr. Schadt, who is also chief executive of Sema4, a diagnostics company. - Eric E. Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://www.nytimes.com/2018/08/13/health/genetic-test-heart-disease.html
STAT News – August 13 Opening The ‘Black Box,’ Google Deepmind AI System Diagnoses Eye Diseases And Shows Its Work — Casey Ross In eye care, artificial intelligence systems have shown they can match the accuracy of doctors in diagnosing specific diseases. But a new system designed by Google DeepMind and British doctors goes a crucial step further: It can show users how it reached its conclusions. Startups and individual doctors are also developing AI-based systems; another paper in Nature Medicine on Monday describes a technology tested by researchers at the Icahn School of Medicine at Mount that uses a deep neural network to identify evidence of acute neurological events such as strokes in CT scans, which could improve outcomes by speeding up diagnosis and treatment. - Icahn School of Medicine at Mount Sinai Learn more: https://www.statnews.com/2018/08/13/google-deepmind-ai-diagnoses-eye-diseases/
STAT News – August 10 That Pathetic Alzheimer’s Pipeline? It’s Even Worse Than You Think — Sharon Begley If it were any other disease, outraged patients and their families would be writing their legislators and demonstrating in front of drug makers’ headquarters. But Alzheimer’s is no ordinary disease, so the latest revelation that very few experimental drugs are being tested to see whether they might help people with moderate, let alone severe, dementia passed this week without so much as an indignant press release from advocacy groups or other Alzheimer’s organizations. Patients with dementia “cannot advocate for themselves said Samuel Gandy, MD, PhD, professor of neurology, psychiatry and associate director of the Alzheimer’s Disease Research Center at the Icahn School of Medicine at Mount Sinai. “Caregivers are too exhausted to be advocates. This shifts the advocacy burden to either young people, who still think of themselves as invincible, or midlife people, whose lives are already overstuffed with children and aging parents, many of whom are in no hurry to add advocacy roles.” - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care Learn more: https://www.statnews.com/2018/08/10/alzheimers-pipeline-clinical-trials/
News-Medical Net – August 13 NIH Awards $6.5 Million To Establish Multi-Institution Biomedical Technology Resource Center The National Institutes of Health (NIH) have awarded $6.5 million to a consortium that includes the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai to establish the Center for Reproducible Biomedical Modeling. The multi-institution biomedical technology resource center will accelerate the development of predictive models of biological systems to guide precision medicine and bioengineering and provide much-needed model building resources to the research community. Jonathan Karr, PhD, assistant professor, genetics and genomic sciences, Icahn School of Medicine at Mount Sinai will direct the consortium's effort to develop computational tools for building reproducible models. "This NIH support significantly impacts our team's capabilities and will enable us to develop the technologies researchers need to build comprehensive whole-cell models," said Dr. Karr, one of the project directors of the center. "Ultimately, we believe these models will help physicians precisely treat individual patients and help bioengineers design powerful microorganisms that can sense and disrupt disease." - Jonathan R. Karr, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180813/NIH-awards-2465-million-to-establish-multi- institution-biomedical-technology-resource-center.aspx
Health Data Management – August 13 Heavy Lifting Ahead As Healthcare Works To Achieve Blockchain’s Potential — Greg Slabodkin Mount Sinai Health System in New York has launched the Center for Biomedical Blockchain Research to solve healthcare challenges using technology that underlies the Bitcoin cryptocurrency and provides a data structure that can be timed-stamped and signed using a private key. “We expect that some early use cases could emerge from areas where existing systems and approaches fall short, adds Joel Dudley, executive vice president of precision health at Mount Sinai and director of the Institute for Next Generation Healthcare. We see the potential for blockchain and related technologies to enable applications that support more unified healthcare ecosystems and serve the greater goals of realizing national and global precision health networks.” - Joel Dudley, PhD, Director, Institute for Next Generation Healthcare, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System Learn more: https://www.healthdatamanagement.com/news/heavy-lifting-ahead-as-healthcare-works-to- achieve-blockchains-potential
NBC 5 Chicago – August 9 World's Tiniest Pacemaker— Bianca Castro Bundle branch block is a congenital heart condition that causes the electrical impulses in the heart to misfire. People with the condition often need a pacemaker to keep their hearts in sync. Now, cardiologists at Mount Sinai Hospital in New York are using a recently approved tiny wireless device in kids, so they don’t miss a beat. Three of the Anthony family’s four children have a condition that blocks the pathway that sends electrical impulses to the heart. Two sons, two pacemakers, over five days. But for Sam, cardiologists were able to implant this tiny wireless pacemaker, approved in 2016 but used now in a handful of kids. Barry Love, MD, a pediatric cardiologist at The Mount Sinai Hospital inserted the Micra pacemaker by threading a catheter through a vein. Dr. Love said, “This pacemaker is entirely contained in the heart itself and because of that he’ll be able to participate in sports and activities with really minimal to no restrictions.” - Barry Love, MD, Assistant Professor of Pediatric Cardiology, Icahn School of Medicine at Mount Sinai Learn more: Learn more: https://www.nbcdfw.com/news/local/Worlds-Tiniest-Pacemaker-490514491.html
Leonoticias (Europa Press Madrid) – August 13 They Develop An Artificial Intelligence Platform That Detects Neurological Diseases Faster Researchers at the Icahn School of Medicine in Mount Sinai have developed an artificial intelligence platform designed to identify a wide range of acute neurological diseases, such as stroke, hemorrhage and hydrocephalus, capable of recognizing the disease in CT scans up to 1.2 seconds, faster than the human diagnosis. "With a total processing and interpretation time of 1.2 seconds, this triage system can alert physicians to a critical finding that might otherwise remain in queue for minutes or hours. We are executing the vision of developing artificial intelligence in medicine that will solve clinical problems and improve patient care, "said lead author Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. This study used "supervised learning approaches" which were based on the experience of the natural language processing research team and the large clinical data sets of the Mount Sinai Health System. - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.leonoticias.com/sociedad/salud/investigacion/desarrollan-inteligencia-artificial- enfermedades-neurologicas-20180813165031-ntrc.html
Medscape – August 10 Risk Model Helps Predict CV Events 1 Year After Acute MI —Megan Brooks Researchers from the United States and China have developed and validated a risk model that may help predict major cardiovascular (CV) events 1 year after discharge for acute myocardial infarction (AMI). Commenting on this research for theheart.org, Robert Rosenson, MD, professor of medicine, cardiology and director of Cardiometabolic disorders at the Icahn School of Medicine at Mount Sinai said, this contemporary analysis of Chinese patients hospitalized with an acute myocardial infarction evaluated 19 risk factors associated with recurrent cardiovascular events. Evaluation of these risk factors improved risk stratification. The use of these data will allow clinicians to focus resources on the highest risk patients and for patients to better understand their own risk. These approaches would be used to develop patient specific strategies that may have an important impact on the risk of cardiovascular disease. Future clinical trials are needed to assess this enhanced risk strategy model.” - Robert Rosenson, MD, Professor, Medicine, Cardiology, Director, Cardiometabolic Disorders, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/900540
Dermatology Advisor – August 13 Addressing Cardiovascular Risks in Psoriasis: Guidance for Clinical Practice — Suzanne Bujara Mounting evidence shows that psoriasis is frequently comorbid with cardiovascular (CV) disorders, and some studies have shown a dose-response effect between the 2 diseases.1 The more severe the psoriasis, the likelier a patient is to have CV concerns. Now, recent evidence from a population cohort study has shown a dose-response effect for psoriasis severity and mortality risk. “When considering psoriasis therapies, dermatologists should think about cardiac risk factors," said Mark G. Lebwohl, MD, professor and chair of dermatology at the Icahn School of Medicine at Mount Sinai and system chair of the Waldman department of dermatology for the Mount Sinai Health System. "For patients with many risk factors, treatments that have been shown in registries to reduce [CV] mortality should be considered. TNF blockers have certainly demonstrated a protective effect.” - Mark G. Lebwohl, MD, Professor, Chair, Dermatology, Icahn School of Medicine at Mount Sinai, System Chair, Waldman Department of Dermatology, Mount Sinai Health System Learn more: https://www.dermatologyadvisor.com/psoriasis/psoriasis-treatment-cardiovascular-risk- factors/article/787620/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 14, 2018 Date: Tuesday, August 14, 2018 1:22:13 PM Attachments: ATT00001.txt
In the News August 14, 2018
Science Daily – August 13 Artificial Intelligence Platform Screens For Acute Neurological Illnesses An artificial intelligence platform designed to identify a broad range of acute neurological illnesses, such as stroke, hemorrhage, and hydrocephalus, was shown to identify disease in CT scans in 1.2 seconds, faster than human diagnosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published in the journal Nature Medicine. "With a total processing and interpretation time of 1.2 seconds, such a triage system can alert physicians to a critical finding that may otherwise remain in a queue for minutes to hours," said senior author Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. "We're executing on the vision to develop artificial intelligence in medicine that will solve clinical problems and improve patient care." This is the first study to utilize artificial intelligence for detecting a wide range of acute neurologic events and to demonstrate a direct clinical application. - Eric Oermann, MD, Instructor, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.sciencedaily.com/releases/2018/08/180813113315.htm Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180814/PULSE/180819972/unitedhealthcare-loses-risk- adjustment-lawsuit-against-dfs (Subscription required) Health Imaging https://www.healthimaging.com/topics/artificial-intelligence/ai-neurological-diseases-ct- 12-seconds United Press International https://www.upi.com/New-AI-system-can-screen-for-neurological-illnesses-in- seconds/3951534177401/ The Times https://www.thetimes.co.uk/article/machines-faster-than-humans-at-diagnosing-brain- injuries-jjz5vbdqq New Scientist https://www.newscientist.com/article/2176618-deepminds-ai-can-spot-eye-disease-just-as- well-as-top-doctors/ HealthCare Business Daily News https://www.dotmed.com/news/story/44083 Radiology Business https://www.radiologybusiness.com/topics/artificial-intelligence/ai-detects- neurologic-events-ct-faster-radiologists
STAT: Morning Rounds – August 14 Switching Antipsychotics Doesn’t Improve Schizophrenia, Study Suggests – Megan Thielking Patients with schizophrenia are often switched to a new kind of antipsychotic if they don’t respond to the first type of treatment – but a new analysis suggests that doesn’t help. Researchers at the Icahn School of Medicine at Mount Sinai ran a randomized trial with 446 patients being treated with amisulpride for schizophrenia. Patients switched to a new drug after a month weren’t any more likely to see improved outcomes than patients who stayed on the first drug. The authors say that suggests it’s not necessary to try another antipsychotic before switching to more aggressive treatment, which could potentially improve outcomes earlier. - Rene S. Kahn, MD, PhD, Esther and Joseph Klingenstein Professor, System Chair, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: No web link available. Additional coverage: MedPage Today https://www.medpagetoday.com/psychiatry/schizophrenia/74554 News Medical & Life Sciences https://www.news-medical.net/news/20180814/Switching-anti-psychotic- drugs-in-first-episode-schizophrenia-patients-does-not-improve-clinical-outcomes.aspx
Genome Web – August 13 Mount Sinai Researchers Use Multi-Omics Approach To Personalize Relapsed Multiple Myeloma Treatment — John Gilmore Mount Sinai researchers have developed a DNA- and RNA-based sequencing computational method to identify genetic mutations in patients with relapsed multiple myeloma and potentially tailor treatments based on tumor susceptibility to certain drugs. "The drugs we can look at using DNA mutations are a smaller set than we could potentially observe for RNA,” explained Samir Parekh, MBBS, associate professor of oncological sciences, medicine, hematology and medical oncology and director of translational research in myeloma at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “Multiple myeloma is not as easily segmented into actionable items for treatment like other conditions such as lung cancer, forcing us to come up with a new strategy.” In the study, Dr. Parekh and his team performed a precision medicine trial of their approach using a group of 64 relapsed multiple myeloma patients. "We are treating not just monolithic cases, but different clones of the disease, where each might have different sensitivity to chemotherapy," Dr. Parekh said. "We therefore need to actively plan a combination approach that would target each clone." - Samir Parekh, MBBS, Associate Professor, Oncological Sciences, Medicine, Hematology and Medical Oncology, Director, Translational Research in Myeloma, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/sequencing/mt-sinai-researchers-use-multi-omics-approach- personalize-relapsed-multiple-myeloma#.W3LY4xsvxQI
News Medical & Life Sciences – August 14 NIH Grant For Mount Sinai To Study Use Of Inhaled Corticosteroids For Treatment Of Sickle Cell Disease The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a four million dollar grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease (SCD) in individuals who do not have asthma. The IMPROVE 2 study is a one-year-randomized placebo-controlled trial involving 80 SCD patients. Over the last decade, researchers at Mount Sinai have demonstrated that pulmonary inflammation is present in mice and humans with SCD. The research team will include experts in hematology, pulmonology, and immunology and will be led by Jeffrey Glassberg, MD, associate professor of emergency medicine, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. “In sickle cell disease, the interaction between the lung and red blood cells represents a potentially high-value therapeutic target,” said Dr. Glassberg. Dr. Glassberg added that patients with SCD will often end up in the emergency department because they experience excruciating pain. He said alternative treatments will improve patient care, reduce ED visits, and lower healthcare expenditures. - Jeffrey Glassberg, MD, Associate Professor, Emergency Medicine, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Comprehensive Program for Sickle Cell Disease Learn more: https://www.news-medical.net/news/20180814/NIH-grant-for-Mount-Sinai-to-study-use-of- inhaled-corticosteroids-for-treatment-of-sickle-cell-disease.aspx Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180814/PULSE/180819972/unitedhealthcare-loses-risk- adjustment-lawsuit-against-dfs (Subscription required) Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/08/14/unitedhealthcares-risk-adjustment-suit-tossed-099895
CBS News – August 2 Boy Develops Normally Despite Having A Sixth Of His Brain Removed — Dennis Thompson The developing brain of a growing child has incredible ways of compensating for the loss of an essential brain region, a new case study shows. A young boy has retained his ability to recognize faces even though surgeons removed one-sixth of his brain, including the region that normally handles that task, his doctors said. Essentially, the other side of the 10-year-old's brain has shouldered the added burden of facial recognition on top of its normal duties, in an astounding feat of adaptation. One expert said the report showed the resilience of the young brain. This study shows that "plasticity is real. Plasticity is key – your brain's golden art of adaptation," said Steven Wolf, MD, associate professor of neurology and pediatrics at the Icahn School of Medicine at Mount Sinai and director of pediatric neurology at Mount Sinai St. Luke’s and Mount Sinai West. "If we get to these kids when they're young enough, before they lay their permanent pathways, the brain is plastic enough for it to adapt and to overcome," said Dr. Wolf. His center has performed the procedure around 500 times over the past decade. - Steven Wolf, MD, Associate Professor, Neurology, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Pediatric Epilepsy, Co-Director, Epilepsy Unit, Mount Sinai Beth Israel, Director, Pediatric Neurology, Mount Sinai St. Luke’s-Mount Sinai West, Co-Director, Tuberous Sclerosis Clinic Learn more: https://www.cbsnews.com/news/boy-develops-normally-despite-having-a-sixth-of-his- brain-removed/
Renal & Urology News – August 14 Acute Renal Failure In CKD Patients Less Likely With PCI Acute renal failure (ARF) occurs less frequently with percutaneous coronary intervention than coronary artery bypass grafting among patients with chronic kidney disease (CKD), according to a new study. The procedures do not differ significantly, however, in terms of the 3-year risk of a composite outcome of death, myocardial infarction (MI), or stroke. ARF within 30 days occurred significantly more frequently in patients with than without CKD, Gennaro Giustino, MD, resident physician at the Zena and Michael A. Wiener Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, and colleagues reported in the Journal of the American College of Cardiology. - Gennaro Giustino, MD, Resident Physician, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.renalandurologynews.com/chronic-kidney-disease-ckd/pci-linked-to-lower- acute-renal-failure-risk-in-chronic-kidney-disease/article/787928/
Medscape – August 13 Three Common Comorbidities With Asthma: Does Their Treatment Improve Outcomes? — Sidney S. Braman, MD and Linda Rogers, MD The comorbidities of asthma have become recognized more and more in the past several years. In 2016, a meta-analysis of 11 studies comprising nearly half a million patients with asthma showed a strong association between asthma and cardiovascular disease, as well as systemic hypertension and gastrointestinal (GI) diseases. Sidney Braman, MD, director of the Pulmonary Disease Management Program at The Mount Sinai Hospital and Linda Rogers, MD, clinical director of the Asthma Program at Mount Sinai National Jewish Health Respiratory Institute discuss three of these comorbidities: GERD, rhinitis (both allergic and nonallergic), and obstructive sleep apnea. - Sidney S. Braman, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, Director, Pulmonary Disease Management Program, Mount Sinai Hospital - Linda Rogers, MD, Associate Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, Clinical Director, Asthma Program, Mount Sinai National Jewish Health Respiratory Institute Learn more: https://www.medscape.com/viewarticle/900265
Psychiatric Times – August 10 Five Reports On Depression — James Murrough, MD, PhD Despite the scope and magnitude of rising rates of depression and suicide, the field of psychiatry may be witnessing a turning point. James Murrough, MD, assistant professor of psychiatry and neuroscience and director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai addresses challenges and barriers that must be overcome in the treatment of depression. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.psychiatrictimes.com/major-depressive-disorder/5-reports-depression
Bustle – August 13 Women With PCOS Are More Likely To Feel Unhappy With Their Doctors, Study Finds — Mariella Mosthof A recent study in the Journal of the Endocrine Society found that PCOS patients are more likely to be unhappy with their medical care than their non-PCOS-suffering counterparts. PCOS, short for Polycystic Ovary Syndrome, is characterized by ovaries enlarged with an unusual number of follicles, irregular periods, and hormonal side effects like acne, excess body hair, and obesity. Frequently, doctors only arrive at a PCOS diagnosis when they’ve ruled out everything else. “When patients say they argue with their physicians, I think the arguments are based on the fact that they have become more knowledgeable than their physicians in this area,” said Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease at the Mount Sinai Health System. She surmises that patients are often put in the position of self-diagnosing using the internet. Thanks to the so-called "research gap," women's pain is often ignored, minimized, or dismissed by physicians. – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://www.bustle.com/p/women-with-pcos-are-more-likely-to-feel-unhappy-with-their- doctors-study-finds-10064744
U.S. News & World Report – August 14 Four Signs You Should Be Readmitted To The Hospital — Anna Medaris Miller Hospital readmissions are, by and large, a bad thing. For patients, they can waste time, suck up energy that would be better dedicated to healing and bring on avoidable medical bills. For hospitals, they can indicate preventable expenses for the health care system, backlogs in emergency departments and poor patient care. But sometimes, going back to the hospital after you’ve returned home is necessary, even life- saving. “People look at it as ‘get out and stay out,’ but when you should think about going back is important too,” said Andrew Dunn, MD, professor of medicine and hospital medicine at the Icahn School of Medicine at Mount Sinai and chief of the division of hospital medicine at the Mount Sinai Health System. Unless you think you’re experiencing an emergency, the best course of action before shuttling yourself back to the hospital is to call the surgeon, cardiologist or other lead clinician who treated you at the hospital, Dr. Dunn said. - Andrew S. Dunn, MD, Professor, Medicine, Hospital Medicine, Icahn School of Medicine at Mount Sinai, Chief, Division of Hospital Medicine, Mount Sinai Health System Learn more: https://health.usnews.com/health-care/patient-advice/articles/2018-08-14/4-signs-you- should-be-readmitted-to-the-hospital
Metro NY – August 13 Ask Mount Sinai: The Eyes Have It — Sheila Dougherty If our eyes are not properly cared for, they can be scratched, blurry or broken. Sumayya Ahmad, MD, cornea surgeon at the New York Eye and Ear Infirmary of Mount Sinai and Erin Walsh, MD, co-director of pediatric ophthalmology at the New York Eye and Ear Infirmary of Mount Sinai, weigh in on how to best protect our eyes. “Most adults over age 21 should have their eyes examined every year. If there is a family history of glaucoma or other eye diseases, or if they have diabetes, then a yearly exam is a definite must,” said Dr. Ahmad. Dr. Walsh said that “typical eye injuries in children are most commonly corneal abrasions, or scratches on the surface of the eye. These are very painful and should be treated with antibiotics to prevent vision-threatening corneal infections. Other common injuries include those to the bones around the eye called orbital bones. Fractures here should be watched closely to evaluate the need for surgical repair.” - Sumayya Ahmad, MD, Cornea Surgeon, New York Eye and Ear Infirmary of Mount Sinai - Erin Walsh, MD, Co-Director, Pediatric Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.metro.us/news/ask-mount-sinai-eyes-examined
Medical Daily – August 14 Heart Attack Or Panic Attack, How To Tell Which You Are Having? — Sadhana Bharanidharan Am I having a panic attack or a heart attack? The question has certainly interrupted the racing minds of people who have experience a cluster of symptoms including discomfort in the chest, increased sweating, dizziness, shortness of breath and trembling. Patients who are having a heart attack often report more of a pressure than a pain, according to MaryAnn McLaughlin, MD, medical director of cardiac health program and co-director of the women’s cardiac assessment and risk evaluation program at the Mount Sinai Hospital. The feeling is compared to wearing a really tight bra or as though the chest is being pressed by something. “There are certain heart attacks that feel like very strong pain. But in general, they start out as a pressure and sometimes a squeezing sensation that can go down either arm,” she explained. - Maryann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co-Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.medicaldaily.com/heart-attack-or-panic-attack-how-tell-which-you-are-having- 426885
HealthDay – August 13 From Pigs To Peacocks, What’s Up With Those ‘Emotional-Support Animals’? — Dennis Thompson It's easy to roll your eyes at the latest news nugget about someone trying to take an "emotional support animal" onto a plane, even though it's too big or out of control. There's the large emotional support peacock that was denied a seat aboard a United Airlines flight in January, for example. Or the young girl who was bitten by an emotional support dog while boarding a Southwest Airlines flight in February. But concern is mounting over people's asserted need for emotional support animals, as more seek accommodations for their pets and livestock in places not designed for bird or beast. Elizabeth Ochoa, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief psychologist of Mount Sinai Beth Israel said that there’s “a lack of empirical research on the efficacy of reducing mental health distress and improving daily life functioning with the use of emotional support animals.” But, Dr. Ochoa added, anecdotal reports have shown that the animals can provide benefit to some people. - Elizabeth Ochoa, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief Psychologist, Mount Sinai Beth Israel Learn more: https://consumer.healthday.com/general-health-information-16/pets-and-health-news- 531/from-pigs-to-peacocks-what-s-up-with-those-emotional-support-animals-736675.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-08-13/from-pigs-to- peacocks-whats-up-with-those-emotional-support-animals
The Paper Gown – August 13 Colonoscopies Are More Complicated For Women — Paige Towers Colonoscopies let gastroenterologists remove precancerous polyps, detect early-stage colorectal cancer and save lives. The American Cancer Society recommends that all adults begin getting colonoscopies at age 45, repeating the procedure every 10 years to every three to five years, depending on family history and colorectal health. While no two colonoscopies will be identical, doctors consistently say performing colonoscopies on female patients is more difficult. The reasons for this are thought to be largely anatomical. David Greenwald, MD, director of clinical gastroenterology and endoscopy at The Mount Sinai Hospital, explained, women’s colons tend to be longer than men’s. It’s also often squished into a smaller abdominal cavity, meaning a gastroenterologist has to maneuver the scope through more twists and angles. - David Greenwald, MD, Senior Faculty, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Clinical Gastroenterology, Endoscopy, The Mount Sinai Hospital Learn more: https://thepapergown.zocdoc.com/colonoscopies-are-more-complicated-for-women/
Insider – August 13 Four Ways To Kick A Nail-Biting Habit, According To A Nail Health Expert — Caroline Praderio Nail biting isn’t just a cosmetic issue. Chronic gnawing ups your risk for slew of unpleasant health problems. First, it can cause long-term nail damage. Biting can actually change nail share, and leave nails with white spots and black or brown stripes. Second, it creates a two-way risk for transferring harmful microorganisms. “The oral cavity is a virtual petri dish and biting can result in the transfer of yeast and bacteria that are normally found in the mouth but should not be on the nails and fingers,” said Dana Stein, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. “This can consequently result in infections of the nail folds; picture red, inflamed, swollen skin surrounding the nail. Conversely, putting your unwashed fingers in your mouth can transfer germs to your mouth, raising the risk of catching a cold or other illness.” - Dana K. Stern, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.thisisinsider.com/how-to-stop-biting-nails-2018-8
The New York Times – August 13 What Is An Essence And Why Is It More Important Than Moisturizer? — Andrea Cheng It has been called ‘miracle water,’ but an essence – the beauty product that’s considered an integral step in Korean and Japanese skin-care routines – is no water. Nor is it a toner, serum or moisturizer. An amalgam of all of the above, this all-in-one has elicited both praise and skepticism since it entered the United States beauty market from Asia about seven years ago. Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital said that the “backbone of any skin care regiment is to make sure that the skin barrier is functioning optimally. Using the appropriate essence for your skin type is one way to hydrate the skin and prime it for the rest of your skin care routine,” he said. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.nytimes.com/2018/08/13/style/skin-care-essence.html
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 17, 2018 Date: Friday, August 17, 2018 11:52:07 AM Attachments: ATT00001.txt
In the News August 17, 2018
United Press International – August 16 Stem Cell Treatment Restores Some Vision In Blind Mice— Amy Norton Scientists say they have restored some degree of vision in blind lab mice, by activating stem cells in their eyes. The procedure is the first of its kind and the researchers hope it will lead to treatments for incurable eye diseases. That treatment involved stem cells that were derived from human embryos, then engineered to develop into specialized retinal cells. Each patient had a "sheet" of cells transplanted into the eye. This latest approach is different: It aims to wake up the regenerative capacity of certain cells that already exist within the retina, explained lead researcher, Bo Chen, PhD, associate professor of ophthalmology and director of the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai. The cells are called Muller glia. And in zebrafish, Dr. Chen said, they act as a source of retinal stem cells – jumping into action when the retina is damaged, to produce healthy new tissue. - Bo Chen, PhD, Associate Professor, Ophthalmology, Director, Ocular Stem Cell Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.upi.com/Health_News/2018/08/16/Stem-cell-treatment-restores-some-vision-in- blind-mice/7431534426528/ Additional coverage: Mirror https://www.mirror.co.uk/science/scientists-restore-sight-mice-research-13091474 World Health Net https://www.worldhealth.net/news/treating-blindness-activating-dormant-retinal- stem-cells/ Pharma Journalist https://www.pharmajournalist.com/pharma-news/nih-funded-researchers-reverse- congenital-blindness-in-mice/ ABC Sociedad https://www.abc.es/sociedad/abci-logran-regenerar-retina-y-revertir-tipo-ceguera- 201808162122_noticia.html Biocentury https://www.biocentury.com/bc-extra/preclinical-news/2018-08-15/gene-transfer-regenerates- rod-cells-restores-light-sensitivity-
CBS News – August 17 New Treatments Offer Hope For Some Breast Cancer Patients — Meg Oliver Recent studies show more women in the U.S. are living with metastatic breast cancer, or breast cancer that has spread. And many are living longer thanks in part to new treatments being tested to try to beat the disease. Morgan Mitchell has four marathons under her belt, works at least 60 hours a week and travels for her job. She’s doing all of this while battling stage 4 breast cancer. Morgan’s doctor, Paula Klein, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, suggested she enroll in a new clinical trial for metastatic breast cancer patients. The experimental treatment combines four different targeted drugs to try to stop cancer cells from growing and spreading. “This is the new way to treat cancer, precision medicine has a lot of different definitions, but clearly going after the unique biology of every cancer is the answer, the holy grail,” Dr. Klein noted. Mount Sinai is the first and only hospital offering the trial which allows patients to avoid chemotherapy and radiation. - Paula Klein, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.ozarksfirst.com/news/new-treatments-offer-hope-for-some-breast-cancer- patients/1377738066
WABC News – August 16 Heart Attack Survivor Has New Life Mission After NYPD Saved His Life A prominent businessman visiting NYC from Delaware is grateful to be alive and thanking the NYPD officers and doctors at Mount Sinai St. Luke’s who saved his life last week. Bill Stevenson, 70, was working last Wednesday when he found himself suffering a major heart attack. He collapsed on the sidewalk and was barely clinging to life. On Thursday, with two stents in place, he had a chance to thank the team of heroes who saved his life. Stevenson was reunited with the two NYPD officers outside his hospital room at Mount Sinai St. Luke’s where his impressive recovery and deeply felt gratitude was on display. It was the first time the two officers had used a defibrillator, other than during training, to bring a person back to life. Now Stevenson is headed back home with a better heart and a new mission. - Mount Sinai St. Luke’s Learn more: https://abc7ny.com/heart-attack-survivor-has-new-mission-after-nypd-saved-his- life/3975098/
Healthline – August 16 Researchers Find Evidence Keto Diet May Increase Type 2 Diabetes Risk— Kristen Fischer Though many people claim the keto diet to be a game changer or a lifesaver, a newly released study raises questions about its ability to cause type 2 diabetes. The study, which was conducted on mice, evaluated the keto diet. The Journal of Psychiatry published the research, which said following the diet in its early phases could boost the risk for type 2 diabetes. The study in mice is at odds with some previous research on the benefits of low-carb diets. Previous short-term studies have shown that low-carb diets — including the keto diet — can improve glucose control in people with type 2 diabetes and lower the amount of medications they need, noted Reshmi Srinath, MD, director of the weight and metabolism management program at the Icahn School of Medicine at Mount Sinai. There isn’t much data on long- term effects of low-carb eating. “We also know that limiting carbohydrates to such a degree can be challenging for some patients and there can be a risk of hypoglycemia (low blood sugar) particularly in patients with type 2 diabetes,” Dr. Srinath said. She recommends carbohydrate moderation, and provides instruction on how people can count and manage carb intake along with the addition of physical activity. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/keto-diet-may-increase-type-2-diabetes-risk
Goop – August 16 A Cardiologist’s Guide For Women: How To Prevent Heart Disease Cardiovascular disease is a global crisis, affecting tens of millions of people every year—but because heart health research and education programs have always focused on men, women worldwide gets too little, too late. Rony Shimony, MD, associate professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and director of clinical cardiology at Mount Sinai West, said there’s a lot we can do to keep our heart healthy. Most of the classic wisdom still rings true for him: Control cholesterol and hypertension, manage stress, and don’t smoke. But modern science has revealed more ways to recognize symptoms, control risk factors, protect your heart, and even, in many instances, reverse damage already done. - Rony Shimony, MD, Associate Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Clinical Cardiology, Mount Sinai West - Valentin Fuster, MD, PhD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Heart, Physician in Chief, Mount Sinai Hospital Learn more: https://goop.com/wellness/health/a-cardiologists-guide-for-women-how-to-prevent-heart- disease/
The Atlantic – August 16 AI-Driven Dermatology Could Leave Dark-Skinned Patients Behind— Angela Lashbrook As the rates of melanoma for all Americans continue a 30-year climb, dermatologists have begun exploring new technologies to try to reverse this deadly trend—including artificial intelligence. There’s been a growing hope in the field that using machine-learning algorithms to diagnose skin cancers and other skin issues could make for more efficient doctor visits and increased reliable diagnoses. The earliest results are promising—but also potentially dangerous for darker-skinned patients. An issue is that decades of clinical research have focused primarily on people with light skin, leaving out marginalized communities whose symptoms may present differently. The reasons for this exclusion are complex. According to Andrew Alexis, MD, MPH, director of the Skin of Color Center at Mount Sinai and chair of the department of dermatology at Mount Sinai St. Luke’s and Mount Sinai West, compounding factors include a lack of medical professionals from marginalized communities, inadequate information about those communities, and socioeconomic barriers to participating in research. “In the absence of a diverse study population that reflects that of the U.S. population, potential safety or efficacy considerations could be missed,” he says. - Andrew Alexis, MD, MPH, Associate Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Skin of Color Center at Mount Sinai, Site Chair, Department of Dermatology, Mount Sinai St. Luke’s-Mount Sinai West Learn more: https://www.theatlantic.com/health/archive/2018/08/machine-learning-dermatology-skin- color/567619/
Healio: Orthopedics Today – August 16 Blog: Patellofemoral Pain Syndrome – A Diagnosis That Does Not Exist The generic term “patellofemoral pain syndrome” is frequently cited as a specific diagnosis, but it has never been specifically defined. In fact, it is not a diagnosis per se. Ronald Grelsamer, MD, associate clinical professor of orthopedics at the Icahn School of Medicine at Mount Sinai said, “to facilitate the arrival at a specific diagnosis, we categorize anterior knee pain into conditions pertaining to patella proper, conditions altogether unrelated to the extensor mechanism.” Due to its persistently ubiquitous use, the so-called patellofemoral syndrome warrants renewed discussion. The term “patellofemoral pain syndrome” is not so much a diagnosis as an amalgam of disparate pathologies with similar presenting symptoms. - Ronald P. Grelsamer, MD, Associate Clinical Professor, Orthopedics, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/orthopedics/sports-medicine/news/blogs/%7B46cd5de6-45c0-4bb5- 9dc7-d0a5d54c81b9%7D/patellofemoral-update/blog-patellofemoral-pain-syndrome-a-diagnosis-that- does-not-exist
Consumer Reports – August 16 Is Honey Good For You? — Lea Ceasrine In the quest to avoid the empty calories of refined sugar, swapping honey into baking recipes is a commonly suggested “healthier” option. So, is honey actually good for you? The no-so-sweet answer: No really, when it’s used as a food. Honey does supply some nutrients, such as iron and vitamin C. But the amounts are so small – less than one percent of what you need in a day – that it’s basically meaningless. The ancient Egyptians used honey to speed wound healing and prevent infection, and there may be some truth that it works. The effect may be due to the antibacterial and anti-inflammatory ingredients quercetin and garlic acid, according to Diane Madfes, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. That said, consult your doctor before you start spreading honey on wounds and burns. - Diane C. Madfes, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.consumerreports.org/sugar-sweeteners/is-honey-good-for-you/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 16, 2018 Date: Thursday, August 16, 2018 2:16:10 PM Attachments: ATT00001.txt
In the News August 16, 2018
U.S. News & World Report – August 15 Stem Cells Restore Some Vision in Blind Mice – Amy Norton Mount Sinai researchers have made history with the first recorded restoration of vision in animal models through activation of retinal stem cells. In a newly published study observing the reactivation of critical cells in mouse models to regain their vision, researchers from the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai have found indications that ophthalmic diseases such as macular degeneration (MD) or retinitis pigmentosa – previously believed to be irreversible – can be reversed. The discovery is in due part to zebrafish. The class of freshwater fish is capable of repairing retina damage within a few days through cellular makeup, said lead researcher, Bo Chen, PhD, associate professor of ophthalmology and director of the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai. “This type of therapeutic treatment is very generous,” Dr. Chen said. “A lot of retina conditions are caused by genetic disease. Restarting the regeneration is being able to correct those problems.” - Bo Chen, PhD, Associate Professor, Ophthalmology, Director, Ocular Stem Cell Program, Icahn School of Medicine at Mount Sinai Learn more: https://health.usnews.com/health-care/articles/2018-08-15/stem-cells-restore-some-vision-in- blind-mice Additional coverage: MD Magazine https://www.mdmag.com/medical-news/retina-stem-cell-therapy-restores-vision-in- animal-models Science Daily https://www.sciencedaily.com/releases/2018/08/180815130544.htm Science Magazine http://www.sciencemag.org/news/2018/08/eye-regeneration-technique-lets-blind-mice- see-light The Scientist https://www.the-scientist.com/news-opinion/reprogrammed-mu-ller-glia-restore-vision-in- mice-64644 HealthDay https://consumer.healthday.com/eye-care-information-13/eye-and-vision-problem-news- 295/stem-cells-restore-some-vision-in-blind-mice-736789.html NewsMax Health https://www.newsmax.com/health/health-news/stem-cells-blindness- mice/2018/08/15/id/877183/ Medical Xpress https://medicalxpress.com/news/2018-08-reverse-congenital-mice.html Health Magazine https://www.health.com/healthday/stem-cells-restore-some-vision-blind-mice STAT: Morning Rounds - No web link available Physics World https://physicsworld.com/a/activating-retinal-stem-cells-restores-vision-in-mice/ News Medical & Life Sciences https://www.news-medical.net/news/20180816/Mount-Sinai-study-could- transform-treatment-for-patients-with-retinal-degenerative-diseases.aspx Genetic Engineering & Biotechnology News https://www.genengnews.com/gen-news-highlights/blind- mice-see-after-gene-factors-stimulate-genesis-of-rod-photoreceptors/81256142 Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/82572 Health On the Net Foundation http://www.hon.ch/News/HSN/736789.html EyeWire Today https://eyewire.news/articles/mount-sinai-researchers-discover-how-to-restore-vision- using-retinal-stem-cells/
Medscape – August 15 New AI Platform Diagnoses Brain Disease In Seconds — George W. Citroner An artificial intelligence (AI) platform accurately identifies acute neurologic events, such as stroke, from CT scans in as little as 1.2 seconds, new research suggests. If the findings are confirmed, this technology would radically speed the triage process by immediately alerting physicians to critical findings that may otherwise have remained in a queue from minutes to hours. "This was our original study that launched our medical AI research consortium in the Mount Sinai Health System,” said senior investigator, Eric Oermann, MD, instructor of the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. “I was motivated by my specific experiences with taking care of patients with acute neurologic illnesses where any possible way of reducing the time it took for me to reach them could have potentially improved their outcomes,” said Dr. Oermann. The study was published in Nature Medicine. - Eric Oermann, MD, Instructor, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/900770
MedPage Today – August 16 OncoBreak: Cancer Breath Tests; Rising Drug Prices— Charles Bankhead A comprehensive RNA-DNA sequencing system showed promise for identifying potential multiple myeloma therapies for patients who have run out of treatment options. - Samir Parekh, MBBS, Associate Professor, Oncological Sciences, Medicine, Hematology and Medical Oncology, Director, Translational Research in Myeloma, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/publichealthpolicy/generalprofessionalissues/74602
New York Daily News – August 15 U.S. News’ Best Hospitals 2018-2019: NYC Tops The List Of The Nation’s Best Health Care Facilities— Joanne Kroeger New York may be known for its championship sports teams, iconic landmarks and trend-setting culture, but it’s also home to the nation’s best health care. U.S. News’ 2018-19 Best Hospital rankings offers New Yorkers a lot more than bragging rights – it provides a guide to finding world-class treatment options in the New York metro area. New York – Presbyterian, NYU Langone, and Mount Sinai remain atop this year’s list, earning spots on the U.S. News’ Honor Roll of the nation’s top 20 hospitals in recognition of their state-of-the-art medical expertise across multiple specialties, procedures and conditions. No. 3- ranked Mount Sinai was ranked 18th on the Honor Roll and third in geriatrics, ninth in gastroenterology and GI surgery and tenth in cardiology and heart surgery. - The Mount Sinai Hospital Learn more: http://www.nydailynews.com/life-style/ny--20180815-story.html
Medical Xpress – August 13 Policy Changes Can Help Ease Roadblocks To A Healthy Diet Diet modification can be a vital step to prevent cardiovascular disease. While various biological, economical, physical, social and psychological factors influence food choices, interventions targeting these factors can lead to meaningful improvements in long-term eating habits, according to a review paper published in the Journal of the American College of Cardiology. This paper is the first in an eight-part health promotion series where each paper will focus on a different risk factor for cardiovascular disease. "The editors and I are quite excited about this series, as we feel it could have tremendous impact in informing clinicians about the prevention of cardiovascular disease," said Valentin Fuster, MD, PhD, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, director of Mount Sinai Heart, physician in chief at The Mount Sinai Hospital, and editor in chief of the Journal of the American College of Cardiology. - Valentin Fuster, MD, PhD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Heart, Physician in Chief, Mount Sinai Hospital Learn more: https://medicalxpress.com/news/2018-08-policy-ease-roadblocks-healthy-diet.html
The Virginian Pilot – August 16 Almost 10,000 People Have Developed Cancer From 9/11 Dust Recent news reports indicate nearly 10,000 people have developed cancer from breathing toxic dust caused by the 9/11 terrorist attacks on the World Trade Center. The World Trade Center Health Program at The Mount Sinai Hospital reportedly receives about 15 to 20 new referrals of 9/11-related cancers each week. Because of the latency periods associated with many cancers, more and more people are diagnosed every year. Victims who are continuing to fight 9/11 cancers have already faced grueling treatments and still have long roads ahead. - The World Trade Center Health Program at Mount Sinai Learn more: https://pilotonline.com/business/ports-rail/article_8b0307d5-4a89-5fd0-8754- bf5561a10529.html
Reuters – August 15 Stocking EpiPens At Restaurants Might Reduce Fatal Allergic Reactions — Carolyn Crist If restaurants and other food establishments stocked epinephrine autoinjectors, the number of fatal allergic reactions, known as anaphylaxis, could decrease, a small study in Canada suggests. The success of the epinephrine autoinjector stocking program depends on several factors, including local government support, effective staff training, low resource requirements and embedding the program into existing policies and procedures. “Whether you’re diagnosed with an allergen already or have your first allergic reaction at a restaurant, this could stop a potentially life-threatening moment,” said Scott Sicherer, MD, professor of pediatrics, allergy and immunology and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai, who was not involved in the study. “When you eat outside of your home, you depend on other people to make food for you,” he said. “This program is a good model that makes sense.” - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-allergy-epipens-restaurants/stocking-epipens-at- restaurants-might-reduce-fatal-allergic-reactions-idUSKBN1L01LE
Self Magazine – August 15 Here’s Exactly How to Treat Those Mosquito Bites All Over Your Body — Korin Miller When you get a mosquito bite, your body reacts with an immune response that leads to those signature pesky symptoms. Mosquito bites cause that intense itchiness because they prompt your body to release histamine, a compound involved in your body’s immune response, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. Specifically, it’s the proteins in mosquitoes’ saliva that trigger your skin to get that itchy red bump. Dr. Goldenberg recommends looking for an oral antihistamine that says it starts working within an hour but also aims to have a 24-hour effect. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.self.com/story/how-to-treat-mosquito-bites
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 15, 2018 Date: Wednesday, August 15, 2018 12:07:26 PM Attachments: ATT00001.txt
In the News August 15, 2018
Crain’s Health Pulse – August 15 Mount Sinai-Led Consortium Gets $6.5 Million For Precision Medicine Work — Jonathan LaMantia A consortium led by the Icahn Institute at Mount Sinai has received $6.5 million from the National Institutes of Health to conduct research on precision medicine. The award comes as the market for precision medicine, which uses factors including genes and lifestyle to individualize treatment, continues to expand. Work funded by the NIH grant will focus on building reusable computer models to advance the field. Jonathan Karr, PhD, assistant professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai will lead the NIH-funded work out of Mount Sinai. Significant advances in precision medicine and bioengineering will require detailed knowledge of cells and other biological entities. However, building predictive and reusable computer models of these biological entities has been limited to date. - Jonathan R. Karr, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180815/PULSE/180819959/state-sues-oxycontin- maker-purdue-for-its-role-in-opioid-crisis Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/08/15/new-york-becomes-latest-to-sue-purdue-pharma-100339
New York City Patch – August 14 See The NYC Hospitals Ranked Best In The State — Brendan Krisel Hospitals in New York City fared well compared to upstate counterparts in the U.S. News & World Report’s annual ranking of the best hospitals in America. The publication evaluated more than 4,500 hospitals in the country across 16 specialties and nine procedures and conditions ranked the best hospital in America by region. Eleven city hospitals made the list of the best hospitals in New York State, with some earning spots on the U.S. News & World Report’s coveted “honor roll.” The city’s honor roll hospitals are New York Presbyterian’s Columbia and Cornell campuses, NYU Langone and The Mount Sinai Hospital. Those three hospitals were also named the top three in New York State. - The Mount Sinai Hospital Learn more: https://patch.com/new-york/new-york-city/eleven-nyc-hospitals-ranked-best-state Additional coverage: Investor Place https://investorplace.com/2018/08/best-hospitals-in-the-u-s/ WebMD https://www.webmd.com/health-insurance/news/20180814/mayo-cleveland-clinics-again-top- hospital-rankings#1
News Medical & Life Sciences – August 15 Innovative Oncofertility Program Launched By RMA of New York and Mount Sinai Health System Reproductive Medicine Associates of New York, a Manhattan-based fertility center, and the Mount Sinai Health System have launched an innovative integrated fertility program at The Blavatnik Family – Chelsea Medical Center at Mount Sinai to provide individuals and couples the benefit of advanced medical technologies to help with someday building their families. "RMA of New York and Mount Sinai are committed to increasing awareness of oncofertility options," said Alan Copperman, MD, director of reproductive endocrinology and infertility at the Icahn School of Medicine at Mount Sinai. “We provide a multi-disciplinary approach designed to empower patients during a very challenging time to realize the desire to have children. Arming patients with the knowledge of options available to them after cancer treatment is our goal." - Alan B. Copperman, MD, Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director, Division of Reproductive Endocrinology and Infertility, Vice Chairman, Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System - Luis Isola, MD, Medical Director, Mount Sinai Cancer, Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180815/Innovative-oncofertility-program-launched- by-RMA-of-New-York-and-Mount-Sinai-Health-System.aspx
Health Data Management – August 15 AI Tool Screens CT Scans For Acute Neurological Illnesses— Greg Slabodkin Researchers at the Icahn School of Medicine at Mount Sinai have developed an artificial intelligence tool that rapidly screens head CT scans. Those who developed the system say it can be used to quickly review images for acute neurological illnesses, such as stroke and hemorrhage. Results of the study published in the journal Nature Medicine, showed that the AI algorithm was much faster than human diagnosis – in fact, 150 faster than the time it takes for physicians to read the images. “With a total processing and interpretation time of 1.2 seconds, such a triage system can alert physicians to a critical finding that may otherwise remain in a queue for minutes to hours,” said senior author, Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. According to the authors, their study is the first to leverage AI for detecting a wide range of acute neurologic events and to demonstrate a direct clinical application. “We’ve married what computers do very well with a clinical need,” adds Dr. Oermann, who is a machine learning researcher and heads the Mount Sinai AI Consortium. “Computers will actually make medicine more efficient.” - Eric Oermann, MD, Instructor, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthdatamanagement.com/news/ai-tool-screens-ct-scans-for-acute- neurological-illnesses
Medical Xpress – August 14 Researchers Artificially Generate Immune Cells Integral To Creating Cancer Vaccines For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in Cell Reports. The researchers discovered a way to grow the immune cells, called dendritic cells, at large scale in the lab to study them for their potential use in highly refined cancer vaccines to prevent patients' cancer from coming back. The ability to generate large numbers of distinct types of human dendritic cells in vitro is critical for accelerating our understanding of dendritic cell biology and to harness them clinically," said Nina Bhardwaj, MD, PhD, professor of medicine, hematology and medical oncology and director of immunotherapy at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “Our system will also be useful for translational applications including in vitro drug and vaccine testing on different dendritic cell types." This research is a jumping-off point for further research on the different types of dendritic cells and other immune cells and has implications for not only boosting cancer-fighting therapies but also to prevent organ transplant rejection, which involves the immune system as well. - Nina Bhardwaj, MD, PhD, Professor, Medicine, Hematology and Medical Oncology, Director, Immunotherapy, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-08-artificially-immune-cells-cancer-vaccines.html Additional coverage: Research Gate https://www.researchgate.net/blog/post/immune-cell-type-best-suited-for-cancer-vaccines- can-now-be-grown-in-the-lab News Medical & Life Sciences https://www.news-medical.net/news/20180815/Researchers-identify-way- to-grow-immune-cells-at-large-scale-for-preventing-cancer-reoccurrence.aspx
STAT – August 15 Medicare Should Pay Doctors More, Not Less, For Treating The Sickest Patients— Timothy Sullivan, MD Some doctors don’t like to admit it, but money can have a major influence on physicians’ behaviors. For years, Medicare seemed to recognize this by paying doctors more for complicated patient visits and less for straightforward ones. In addition to properly compensating physicians for challenging work, this payment schedule helped encourage them to take on complex, time-consuming cases. The federal government recently announced plans to drastically alter Medicare payments to physicians by instituting a flat rate per visit, regardless of how sick a patient is. This change, which is slated to start in 2019, could have unintended — and harmful — consequences for patients with severe illnesses. Timothy Sullivan, MD, assistant professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai said “the effects of this policy could be catastrophic. Doctors will be pressured by clinic administrators to see more patients each day to maintain revenue, which will encourage them to treat more patient with simpler problems and fewer with complex, time-consuming health issues.” - Timothy Sullivan, MD, Assistant Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.statnews.com/2018/08/15/medicare-payments-doctors-sickest-patients/
Today – August 14 Clues To Your Health Are Hidden At 6.6 Million Spots In Your DNA Scientists have created a powerful new tool to calculate a person’s inherited risks for heart disease, breast cancer, and three other serious conditions. By surveying changes in DNA at 6.6 million places in the human genome, investigators at the Broad Institute and Harvard University were able to identify many more people at risk than do the usual genetic tests, which take into account very few genes. People may need genetic counseling before and after getting these sorts of risk scores, noted Eric Schadt, MD, dean of precision medicine and professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. Patients may not appreciate the consequences of learning they have a high likelihood of having a heart attack or breast cancer or one of the other disease the test assesses. "Do people really understand that once you learn something you cannot unlearn it?" said Dr. Schadt. - Eric E. Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://www.todayonline.com/world/clues-your-health-are-hidden-66-million-spots-your- dna
CBS New York – August 14 Doctor On Smart Device Blue Light Study: ‘Don’t Freak Out’ – Hazel Sanchez A new study in the journal Scientific Reports claims that smartphones could damage eyesight. Researchers have found that eye exposure to blue light, which is emitted in the bright glow from most smartphone, laptop and tablet screens, can cause cells in the retina to produce a toxin that causes vision loss. Jessica Lee, MD, retina surgeon at the New York Eye and Ear Infirmary of Mount Sinai, noted that in the study researchers used direct blue light on the cells of mice, not every day blue light exposure to human eyes. “This was a study that was done in the lab, and it wasn’t done every day with the light we see, that we’re exposed to,” Dr. Lee said. “I don’t think you need to freak out. You don’t have to run out to the store and get a screen protector. Sure it can’t hurt, but is it absolutely necessary and crucial to prevent blue light damage? I think we have to wait for more research.” While the study may have some people worried about excessive screen time, opthamologists remind us the sun actually gives us a stronger level of blue light than our digital devices. - Jessica Lee, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Retina Surgeon, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://newyork.cbslocal.com/2018/08/14/study-blue-light-from-smart-devices-may-lead-to- blindness/
STAT – August 15 As Alzheimer’s Drug Developers Give Up On Today’s Patients, Where Is The Outrage? — Sharon Begley The lack of progress against Alzheimer’s disease has brought somewhat less outrage. Although the latest analysis of experimental Alzheimer’s drugs finds that literally zero are being tested in late-stage clinical trials to treat moderate to severe Alzheimer’s, no patient advocacy groups uttered a peep in protest. “We need a Larry Kramer,” said Samuel Gandy, MD, PhD, professor of neurology, psychiatry, and associate director of the Alzheimer’s disease Research Center at the Icahn School of Medicine at Mount Sinai, referring to the AIDS activist. Instead, he said, patients and their families adopt the fatalistic attitude that dementia is an inevitable consequence of aging, and funders see spending $1 on curing a child as ethically more justified than spending $1 on an 80 year old, who’s closer to the grave. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care Learn more: https://www.statnews.com/2018/08/15/alzheimers-patients-drug-development-outrage/
Reuters – August 3 Women With Common Ovary Condition Often Feel Medical System Failed Them— Linda Carroll Many women with polycystic ovary syndrome feel they’ve been let down by a health care system that takes years to diagnose their condition, a new survey suggests. Researchers found that women with polycystic ovary syndrome, or PCOS, a common condition characterized by metabolic and fertility problems, were more likely than others to distrust their primary care physician’s judgment and to feel that they weren’t getting enough social support from health care providers. A contributor to delayed diagnosis may be primary care physicians’ lack of familiarity with the condition, not to mention the latest information on it, said Andrea Dunaif, MD, chief of the division of endocrinology, diabetes and bone disease for the Mount Sinai Health System. The name, which is really a misnomer, doesn’t help, she added. The bumps on the ovaries aren’t cysts and the condition has symptoms that go far beyond the reproductive system, she explained. PCOS has also been linked to increased risks for diabetes, obesity and heart disease. – Andrea Dunaif, MD, Chief, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai Health System Learn more: https://www.reuters.com/article/us-health-pcos/women-with-common-ovary-condition- often-feel-medical-system-failed-them-idUSKBN1KO2L3
Spine Universe – August 14 Magnetic Kyphoplasty May Optimize Drug Delivery In Spinal Compression Fractures — Kristin Della Volpe While conservative pain management, kyphoplasty, and bone strengthening agents are the mainstays of spinal compression fracture management, treatment in the future may involve improved prediction of which vertebral bodies are at risk using finite element modeling and targeted delivery drug delivery at the side of bone breakdown using magnetic kyphoplasty. Magnetic kyphoplasty “certainly has the potential to provide targeted drug therapy, and I am excited to see further development of this technology in the future,” commented Samuel Cho, MD, associate professor of orthopedics, neurosurgery, director of spine surgery fellowship at the Icahn School of Medicine at Mount Sinai and chief of spine surgery at Mount Sinai West. “This is a proof-of-concept animal study that has demonstrated potential benefits of a new technology. There still needs to be a lot of work done to prove both safety and efficacy in humans.” - Samuel K. Cho, MD, Associate Professor, Orthopedics, Neurosurgery, Director, Spine Surgery Fellowship, Icahn School of Medicine at Mount Sinai, Chief, Spine Surgery, Mount Sinai West Learn more: https://www.spineuniverse.com/professional/news/magnetic-kyphoplasty-may-optimize- drug-delivery-spinal-compression-fractures
WABC News – August 14 Push To Find Organ Donors for Those Sickened At Ground Zero After 9/11 Attacks Many types of cancer have been reported among the life-threatening illnesses that have attacked hundreds of thousands of people who were in the vicinity of Ground Zero after the September 11, 2001 terror attacks. And now there is a big push to find organ donors for those suffering from 9/11-related illnesses. Experts say kidney cancer appears to be part of yet another wave of 911-related illnesses, following conditions like asthma and acid reflux, thyroid and prostate cancer. “It’s certainly related to the exposure, there’s no doubt in my mind,” said Michael Crane, MD, director of the World Trade Center Health Program Clinical Center at The Mount Sinai Hospital. “We do seem to be having them picked up at a point where we can treat them effectively,” he added. - Michael Crane, MD, MPH, Associate Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, Director, World Trade Center Health Program Clinical Center of Excellence, The Mount Sinai Hospital Learn more: https://abc7ny.com/health/push-to-find-organ-donors-for-those-with-9-11-related- illnesses/3957251/
Medscape – August 14 Lung Cancer Over Diagnosis Rate 67 Percent in Danish Low-Dose CT Trial — Megan Brooks Roughly two thirds of lung cancers detected with low-dose CT represent overdiagnosis, report investigators from the Danish Lung Cancer Screening Trial. This rate of overdiagnosis is far higher than that found in two other major studies, the National Lung Screening Trial (NLST), which estimated that 18.5 percent of screen-detected lung cancers represented cases of overdiagnosed, and the Italian Lung Cancer Screening Trial (ITALUNG), which found no evidence of overdiagnosis. "The estimate for overdiagnosis is quite high" compared to the estimates in the ITALUNG and NLST, said David Yankelevitz, MD, professor of radiology at the Icahn School of Medicine at Mount Sinai. “This article adds to the confusion on this important topic. Based on this study, over half of the screen-detected cancers are overdiagnosed, which would have major implications for a person considering screening," said Dr. Yankelevitz, who was not involved in the study. - David F. Yankelevitz, MD, Professor, Radiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/900709
The Washington Post – August 14 The FDA Approved An App To Prevent Pregnancy. Can An App Do That? — Rachel Siegel Natural Cycles became the first app approved by the government to prevent pregnancy. The Swedish- based company had been cleared in Europe in 2017 and is an emerging name within the “Femtech” industry – a catch-all for “female health technology.” This app is marketed as a natural method of contraception that is powered by a smart algorithm. It sells the idea of empowering women. Laura MacIsaac, MD, associate professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai, said Natural Cycles was “a little more exciting” in that it tracks both menstrual calendars and basal body temperature. But she cautioned against forms of contraception that require such intense maintenance and attention, especially for women seeking long-term pregnancy protection. Even women who obsessively comply with the program will be fertile for a stretch of every month, she explained. She added that contraception methods that are highly labor intensive are also hard to stick with. - Laura MacIsaac, MD, Associate Professor, Medical Education, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.washingtonpost.com/business/2018/08/14/fda-approved-an-app-prevent- pregnancy-can-an-app-do-that/?utm_term=.da9b0a776f97
Healthline – August 14 Maternal Deaths In U.S. Are Up, So How Did California Cut Them By Half? — Claire Cameron In the United States, a woman’s chances of dying during or after pregnancy are higher than in any other developed nation – and they have been steadily getting worse. The Centers for Disease Control and Prevention puts the ratio at 18 maternal deaths for every 100,000 births. Meanwhile, in Canada the rate is 7 maternal deaths for every 100,000 live births. While the United States overall has been grappling with high maternal death rates, there is one state that has been able to reverse the trend: California. California wants other states to copy their example, and it reflects a shift in attitudes to maternity care more broadly, said Elizabeth Howell, MD, MPP, director of the Blavatnik Family Women’s Health Research Institute at the Icahn School of Medicine at Mount Sinai. The American College of Obstetrics and Gynecology has released similar guidelines, or “bundles,” for hemorrhage and other medical emergencies. “There is a big national effort to improve care in hospitals,” said Dr. Howell. - Elizabeth A. Howell, MD, MPP, Associate Dean, Academic Development, Director, The Blavatnik Family Women’s Health Research Institute, Professor, Population Health Science and Policy, Psychiatry, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/maternal-deaths-in-us-up-california-cut-by-half
Newsmax – August 14 Seven Hidden Symptoms of Thyroid Problems— Jen Krausz Thyroid problems can be tricky to diagnose because the symptoms are similar to many other health problems. Many Americans have thyroid problems and don’t even know it because the symptoms can be subtle and hard to detect. Here are some hidden symptoms of thyroid problems that may signal that a trip to the doctor for a thyroid test is in order. Many people experience brain fog for a variety of reasons, and one of those reasons could be an underactive thyroid, according to Ashita Gupta, MD, assistant clinical professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Having more than the normal amount of trouble remembering things or just overall mental fatigue are other related signs that your thyroid may need some attention. - Ashita R. Gupta, MD, Assistant Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.newsmax.com/fastfeatures/thyroid-problems-hidden- symptoms/2018/08/14/id/877001/
Prevention – August 14 The Seven Best OTC Retinal Creams For Smoother, Younger-Looking Skin — Jessica Migala If you want to maintain a youthful complexion, there’s one ingredient dermatologists will always stand by: retinoids, which are vitamin A derivatives that will help improve skin cells turnover. “When you apply a retinoid, you’re constantly exfoliating the top layers of skin,” said Meera Sivendran, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. This prevents fine lines, wrinkles, improves skin texture, lighten dark spots, and unclog pores to keep blackheads and whiteheads away. Retinol makes your skin more sensitive to the sun, especially if you decide to use one during the day. If you don’t protect your face with sunscreen, you may be setting yourself up for more damage like burning or discoloration in the long run. - Meera Sivendran, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/beauty/skin-care/g22718511/best-retinol-face-cream/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 20, 2018 Date: Monday, August 20, 2018 2:04:38 PM Attachments: ATT00001.txt
In the News August 20, 2018
Laboratory Equipment –August 17 Researchers Reverse Congenital Blindness In Mice Researchers funded by the National Eye Institute have reversed congenital blindness in mice by changing supportive cells in the retina called Muller glia into rod photoreceptors. The findings advance efforts towards regenerative therapies for blinding diseases such as age-related macular degeneration and retinitis pigmentosa. “From a practical standpoint, if you’re trying to regenerate the retina to restore a person’s vision, it is counterproductive to injure it first to activate the Müller glia,” said Bo Chen, PhD, associate professor of ophthalmology and director of the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai. “We wanted to see if we could program Müller glia to become rod photoreceptors in a living mouse without having to injure its retina,” said Dr. Chen, the study’s lead investigator. Dr. Chen’s lab is conducting behavioral studies to determine whether the mice have regained the ability to perform visual tasks such as a water maze task. Dr. Chen also plans to see if the technique works on cultured human retinal tissue. - Bo Chen, PhD, Associate Professor, Ophthalmology, Director, Ocular Stem Cell Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.laboratoryequipment.com/news/2018/08/researchers-reverse-congenital- blindness-mice Additional coverage: Interesting Engineering https://interestingengineering.com/scientists-restore-vision-in-blind-mice-using- retinal-stem-cell-technique Science News http://www.sci-news.com/medicine/congenital-blindness-mice-06321.html
CBS Chicago – August 17 New Breast Cancer Treatments Helping Women Live Longer, Better Lives Recent studies show more women in the U.S. are living with metastatic breast cancer, or breast cancer that has spread, and many are living longer thanks in part to new treatments being tested to try to beat the disease. Morgan Mitchell has four marathons under her belt, works at least 60 hours a week, and travels for her job. She’s doing all of this while battling stage 4 breast cancer. Paula Klein, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, who is treating Morgan, suggested she enroll in a new clinical trial for metastatic breast cancer patients. The experimental treatment combines four different targeted drugs to try to stop cancer cells from growing and spreading. “This is the new way to treat cancer. Precision medicine has a lot of different definitions, but clearly going after the unique biology of every cancer is the answer, the holy grail,” Dr. Klein said. Mount Sinai is the first and only hospital offering the trial, which allows patients to avoid chemotherapy and radiation. - Paula Klein, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://chicago.cbslocal.com/2018/08/17/new-breast-cancer-treatments-clinical-trial/ Additional coverage: WCAX http://www.wcax.com/content/news/New-treatments-offering-hope-to-breast-cancer-patients- 491125041.html
HealthCare Business Daily News – August 17 Study: AI Detects Neurological Issues On CT Scans Under Two Seconds— John R. Fischer Scanning for neurological conditions may take little more than one second using an AI platform designed to identify a broad range of these issues, according to a new first-of-its-kind study. Researchers at the Icahn School of Medicine at Mount Sinai found that identifying diseases took as little as 1.2 seconds by applying AI to CT scans of stroke, hemorrhage, hydrocephalus and other neurological problems. The study is the first to demonstrate a direct clinical application based on the application of AI in directing a wide range of acute neurological conditions. "With a total processing and interpretation time of 1.2 seconds, such a triage system can alert physicians to a critical finding that may otherwise remain in a queue for minutes to hours," said senior author, Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. “We’re executing on the vision - Eric Oermann, MD, Instructor, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.dotmed.com/news/story/44111
AARP News – August 17 New Hope For Aging Eyes — Richard Laliberte Charles Friedlander had the heebie-jeebies about cataract surgery. But on the day of surgery, he’s calm and relaxed on a gurney at the New York Eye and Ear Infirmary of Mount Sinai, awaiting his second procedure in four weeks. The first went well so he thought why not get the other eye done. The focal point of Friedlander’s surgery is the artificial lens his ophthalmologist, Tal Raviv, MD, associate clinical professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, will insert in place of the stiff, cloudy, natural lens in Friedlander’s right eye. Called the Tecnis Symfony, the replacement is a newly approved, first-in-class EDOF — extended depth of focus — lens. “It’s such a big leap forward that the Food and Drug Administration has recognized this as a completely new category of lens,” Dr. Raviv says. - Tal Raviv, MD, Associate Clinical Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://www.aarp.org/health/conditions-treatments/info-2018/new-eye-treatments- glaucoma-cataracts.html
Brit + Co – August 19 When Should You Really Start An Anti-Aging Regimen? — Val Vicenty A number of dermatologists say it’s never too early to start an anti-aging regimen, but most agree that starting in your late 20s to mid-30s is a good time. “Over the year, the paradigm has shifted from treatment of skin aging signs beginning after 40 or 50 to the prevention of skin aging,” said Andrew Alexis, MD, MPH, director of the Skin of Color Center at Mount Sinai and chair of the department of dermatology at Mount Sinai St. Luke’s and Mount Sinai West. Though UV rays, airborne pollution, stress, and other free radicals can contribute to the breakdown of collagen that causes skin aging, their effects might differ depending on your tone. “Due to the sun-protective effects of melanin, manifestations of skin aging in skin of color tend to be less severe and delayed by as much as a decade in comparison to lighter skin types,” said Dr. Alexis. - Andrew Alexis, MD, MPH, Associate Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Skin of Color Center at Mount Sinai, Site Chair, Department of Dermatology, Mount Sinai St. Luke’s-Mount Sinai West Learn more: https://www.brit.co/anti-aging-skincare-start-dermatologist-approved-products/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 21, 2018 Date: Tuesday, August 21, 2018 1:16:25 PM Attachments: image002.png ATT00001.txt
In the News August 21, 2018
Modern Healthcare – August 21 100 Most Influential People in Healthcare in 2018 The 100 most influential people in healthcare awards honors individuals in healthcare who are deemed by their peers and the senior editors of Modern Healthcare to be the most influential individuals in the industry, in terms of leadership and impact. Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System, was a selected honoree on the list. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System Learn more: http://www.modernhealthcare.com/community/100-most-influential/2018/ (Need subscription)
Crain’s Health Pulse – August 21 Modern Healthcare Names Influencers — Jonathan LaMantia Six New York executives landed on Modern Healthcare's 2018 list of the 100 Most Influential People in the industry, mostly at the tail-end. Other local executives included Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180821/PULSE/180829980/nyu-researchers-team- with-facebook-on-ai-project-to-speed-up-mris (Need subscription)
Bio News – August 20 Gene Therapy Kick Starts Stem Cells To Help Blind Mice See — Dr. Kimberly Bryon-Dodd Scientists have partially restored sight in mice with congenital blindness by using gene therapy to activate retinal stem cells. Humans and mice have supportive cells at the back of the eye called Müller glia cells, which in some animals such as zebrafish act as stem cells - replacing damaged cells to restore sight. However, this is not the case in mammals. In the current study, researchers have managed to trigger the Müller glia cells into becoming one type of light receptor cell – rod photoreceptors – without needing to injure the animal's eye. “The biggest takeaway from this paper is that it is possible to reprogramme Müller glia in mammalian retina and partially restore visual function,” said Bo Chen, PhD, associate professor of ophthalmology and director of the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai. Rod photoreceptors help the eye to detect light at lower levels, and also help preserve a second set of photoreceptors in the retina called cones, which are important for color vision. By using this technique in mice that were born blind the scientists were also able to show that the neurons responded to light and the cells were therefore functional. - Bo Chen, PhD, Associate Professor, Ophthalmology, Director, Ocular Stem Cell Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.bionews.org.uk/page_137898
MD Alert – August 17 Simple Algorithm May Improve Schizophrenia Symptoms Sooner — Marilynn Larkin Most patients in the early stages of schizophrenia can achieve symptom remission with sequential administration of amisulpride and clozapine, and the latter should be given after patients fail a single antipsychotic trial, researchers say. The study is practice-changing, and clinical guidelines should be changed as a result, said Rene S. Kahn, MD, PhD, Esther and Joseph Klingenstein professor and system chair of psychiatry at the Icahn School of Medicine at Mount Sinai. "For most patients in the early stages of schizophrenia, symptomatic remission can be achieved using a simple treatment algorithm comprising the sequential administration of amisulpride and clozapine," he added. "Since switching to olanzapine did not improve outcome, clozapine should be used after patients fail a single antipsychotic trial - not until two antipsychotics have been tried, as is the current recommendation." - Rene S. Kahn, MD, PhD, Esther and Joseph Klingenstein Professor, System Chair, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/simple-algorithm-may-improve-schizophrenia- symptoms-sooner
Futura Brazilian TV – August 20 Biotechnology and The Future of Health What happens when biotechnology leaves the laboratories and is disseminated among enthusiasts? David Stark, MD, medical director of the Institute for Next Generation Health Care and Joel Dudley, PhD, director of the Institute for Next Generation Health Care and executive vice president of precision health for the Mount Sinai Health System showcase Lab100 at Mount Sinai. Lab100 is a hybrid clinic and research lab leveraging data and technology to redesign the way health is measured and health care is delivered. - David Stark, MD, Assistant Professor, Health System Design and Global Health, Icahn School of Medicine at Mount Sinai, Medical Director, Institute for Next Generation Health Care - Joel Dudley, PhD, Director, Institute for Next Generation Healthcare, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System Learn more: http://www.futuraplay.org/video/biotecnologia-e-o-futuro-da-saude/436705/
Newsday – August 20 Acetaminophen Use During Pregnancy Associated With Higher Rate Of Language Delay in Girls In the first study of its kind, researchers from the Icahn School of Medicine at Mount Sinai found an elevated rate of language delay in girls at 30 months old born to mothers who used acetaminophen during pregnancy, but not in boys. This is the first study to examine language development in relation to acetaminophen levels in urine. "Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy," said the study's senior author, Shanna Swan, PhD, professor of environmental medicine and public health, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. "It's important for us to look at language development because it has shown to be predictive of other neurodevelopmental problems in children." - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.newsday.com/news/health/acetaminophen-risk-pregnancy-1.20584516
MedPage Today – August 20 Diverting Contrast No Help For AKI After Coronary Angiography — Nicole Lou Despite success in cutting down on contrast media volume, the Avert system didn't reduce the risk of acute kidney injury (AKI) after coronary angiography, a trial found. Operators used 85.6 mL of contrast when patients were randomized to hydration plus manual contrast injection with the contrast modulation system (versus 101.3 mL with hydration alone, P=0.02), and 114 mL in the subset of percutaneous coronary intervention (PCI) recipients (versus 147 mL with hydration alone, P=0.001), according Roxana Mehran, MD, professor of medicine, cardiology, and director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. Avert is a device that diverts contrast during coronary injection; the amount of contrast medium sent away depends on injection force and the setting selected on the contrast modulator. Dr. Mehran's group noted that having most patients undergo diagnostic procedures only could have reduced their power to show a difference in contrast-induced AKI between groups. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/pci/74648 Additional coverage: Healio: Cardiology Today https://www.healio.com/cardiac-vascular-intervention/percutaneous-coronary- intervention/news/online/%7B889db137-94c6-4380-83e2-ddc2354961da%7D/modulation-system-reduces- contrast-media-volume-without-compromising-image-quality
Neurology Advisor – August 20 OnabotulinumtoxinA For Post-Stroke Spasticity: Treatment Strategies and Limitations — Linda Peckel Spasticity is a common occurrence following stroke, with an estimated 20 to 40 percent of patients developing spasticity that hampers activities of daily living (ADL). Lower limb spasticity in particular is associated with impairments of gait and mobility. Several types of therapy are available to facilitate post- stroke recovery of movement, including the use of botulinum toxin injections, as well as physical therapy and anti-spasmodic medications as first-line options. Improvements with these therapies are often less than optimal, according to David M. Simpson, MD, professor of neurology, neuromuscular diseases, director of the neuromuscular division and neuro-AIDS program at the Icahn School of Medicine at Mount Sinai. He said, “Treatment goals are individualized for each patient. In some more severely affected patients, only passive goals are possible, such as improvement in limb position, caregiver dressing, or applying braces. In others, higher level active functional goals are possible, such as improved arm use and gait.” - David Simpson, MD, Professor, Neurology, Neuromuscular Diseases, Director, Clinical Neurophysiology Laboratories, Director, Neuromuscular Division, Director, Neuro-AIDS Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.neurologyadvisor.com/movement-disorders-advisor/treating-post-stroke- spasticity-with-botulinum-toxin-type-a/article/789803/
Endocrinology Advisor – August 21 Nutraceuticals May Benefit Patients Who Are Statin Intolerant — Suzanne Bujara Nutraceuticals may offer a solution to patients who cannot tolerate statins because of severe muscle pain. Emerging evidence shows that red yeast rice (RYR), bergamot, berberine, artichoke, soluble fiber, and plant stanols and sterols as monotherapy or adjunctive therapy may offer an alternative, along with ezetimibe, to prevent cardiovascular events by lowering low-density lipoprotein-cholesterol (LDL-C). With the SAMS-CI, clinicians can systematically evaluate muscle symptoms as well as “associated adverse events — hypothyroidism, very low vitamin D levels, and drug-drug interactions,” explained Robert Rosenson, MD, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai. “This approach begins with assessment, screening for secondary disorders and drug interactions followed by a change to another statin, dose reduction of the statin, alternate-day statin therapy, and possibly nutraceuticals.” - Robert S. Rosenson, MD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.endocrinologyadvisor.com/cardiovascular-and-metabolic- disorders/nutraceuticals-beneficial-statin-intolerant/article/789480/
Rewire News – August 13 Intersex People Want To End Nonconsensual Surgeries. A California Resolution Is Their ‘Warning Shot’—Amy Littlefield A growing number of patients have spoken out in recent years about how surgeries, performed when they were too young to understand—much less give consent—have deprived them of sexual pleasure, sterilized them, traumatized them, or altered their bodies to reinforce a gender assignment that is not theirs. But unlike people operated on as infants, transgender youth often must consult with mental health providers and demonstrate that they are firm in their identities and aware of the risks of medical options. Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai, said the comparison works only in the sense that trans people make a range of decisions about surgery, and intersex people should be able to do the same. “It is kind of ironic that we are dealing with a reality where transgender individuals are having difficulty getting enough surgery, and intersex individuals are suffering from too much surgery,” Dr. Safer said. “But the theme that we have from both situations is that we are looking for the individual to participate in the decision.” - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://rewire.news/article/2018/08/13/intersex-people-want-to-end-nonconsensual- surgeries-a-california-resolution-is-their-warning-shot/
Everyday Health – August 20 Many Women, And Their Doctors, Don’t Recognize Female Heart Attack Symptoms — Fran Kirtz A review of research published in Current Cardiology Reports, finds that women have wait times that are 30 percent longer from the time symptoms start until their first contact with medical help compared with men, and wait time that are 20 percent longer than first arriving at the hospital until specific treatment for the heart attack, compared with men. Knowing your risk factors, and doing something about them, can prevent heart attacks in the first place, said Suzanne R. Steinbaum, DO, senior faculty of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and director of the Women’s Cardiovascular Prevention, Health and Wellness at The Mount Sinai Hospital. “Knowing your numbers is the first step. The next step is understanding that if your risk is high, you need to pay extra attention to your heart symptoms.” - Suzanne R. Steinbaum, DO, Senior Faculty, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Women’s Cardiovascular Prevention, Health and Wellness, The Mount Sinai Hospital Learn more: https://www.everydayhealth.com/heart-attack/symptoms/many-women-their-doctors-dont- recognize-female-heart-attack-symptoms/
Scary Mommy Blog – August 21 How Mental Illness Can Impact Sleep Habits — Clint Edwards Science has come one step closer to figuring out what’s going on in the brains of those struggling with mental illness and sleeplessness. Researchers have pinned down the part of the brain that keeps depressed and anxious people up at night. Ariella Silver, PsyD, assistant professor of pediatrics, adolescent medicine and psychiatry at the Icahn School of Medicine at Mount Sinai said, “It’s really important to employ good sleep hygiene.” She recommends going to sleep at the same time, and getting up at the same time. I know, with kids this can feel like an impossible task, but it is doable. She also suggests creating a sleep routine, which could include “wind-down” self-care activities like reading, diffusing calming essential oils in your bedroom, or even sitting silently as you focus on relaxing breathing techniques. - Ariella Silver, PsyD, Assistant Professor, Pediatrics, Adolescent Medicine, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.scarymommy.com/mental-illness-impact-sleep-habits/
Reader’s Digest – August 20 51 Things Dermatologists Need You To Know About Skin Cancer — Charlotte Hilton Andersen We like to pretend otherwise, but skin cancer is the most common cancer there is. Learn from dermatologists how to avoid trouble. There’s a common myth that any sunscreen over, say SPF 30, doesn’t provide significant extra protection and it’s just a marketing ploy for companies to get more money. Not true, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. “In a recent study, an SPF 100+ sunscreen was shown to give statistically more protection as compared to an SPF 50 product,” he said. “For that reason, I recommend patients use the highest level of protection possible.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.rd.com/health/conditions/things-dermatologists-need-know-skin-cancer/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 22, 2018 Date: Wednesday, August 22, 2018 1:54:03 PM Attachments: ATT00001.txt
In the News August 22, 2018
Sickle Cell Anemia News – August 21 NIH Awards $4 Million For Research In Inhaled Corticosteroids For SCD — Janet Stewart The National Institutes of Health has awarded $4 million to the departments of emergency medicine and hematology at the Icahn School of Medicine at Mount Sinai to test a creative approach for treating sickle cell disease. The strategy involved inhaled corticosteroids that will deliver the anti-inflammatory medication directly to the patient’s lungs. “In sickle cell disease, the interaction between the lung and red blood cells represents a potentially high-value therapeutic target,” said Jeffrey Glassberg, MD, associate professor of emergency medicine, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. “Hydroxyurea is the primary FDA-approved drug for treatment, but it is underutilized due to side effects, stigma, and fertility concerns. Other promising drugs are coming, but their costs, efficacy, and scalability are hard to predict at this point. Inhaled corticosteroids offer a creative new approach with the potential to dramatically improve patient outcomes,” he said. - Jeffrey Glassberg, MD, Associate Professor, Emergency Medicine, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://sicklecellanemianews.com/2018/08/21/nih-awards-4-million-for-research-on-sickle- cell-disease-treatment/
Block Telegraph –August 21 Mount Sinai Bets Big On Blockchain To Transform Healthcare Industry —Ian Haynes Healthcare Analytics News reported the Icahn School of Medicine at Mount Sinai has launched the Center for Biomedical Blockchain Research, the first academic center focusing on blockchain in healthcare, via a partnership with the Mount Sinai Institute for Next Generation Healthcare, a medical lab that conducts research on application of artificial intelligence (AI), genomic sequencing, robotics, and sensors in medicine. “There is a lot of excitement around the possibilities for blockchain technology in healthcare. However, we still have lots of hard work ahead to identify the most salient features of blockchain technologies to solve real-world healthcare problems,” says Joel Dudley, PhD, director of the Institute for Next Generation Health Care and executive vice president of precision health for the Mount Sinai Health System. - Joel Dudley, PhD, Director, Institute for Next Generation Healthcare, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System Learn more: https://blocktelegraph.io/mount-sinai-blockchain-healthcare/
Medical Xpress – August 20 Prevention And Cessation Best Options To Reduce Tobacco-Related Heart Disease Tobacco use is the leading preventable cause of death in the world and encompasses a variety of products, including cigarettes, e-cigarettes and smokeless tobacco. Combustible cigarettes remain the most common tobacco product used by U.S. adults, but studies have shown no level of cigarette consumption is safe. A new review—published today in the Journal of the American College of Cardiology— examines policies to achieve complete cigarette abstinence as part of efforts to reduce the risk of heart disease. "This manuscript is the second in an eight-part health promotion series where each paper will focus on a different risk factor for cardiovascular disease, and given the ongoing prevalence of tobacco use globally, this paper should have particular resonance," said Valentin Fuster, MD, PhD, MACC, editor-in-chief of the Journal of the American College of Cardiology. "The editors and I are quite excited about this series, as we feel it could have tremendous impact in informing clinicians about the prevention of cardiovascular disease." - Valentin Fuster, MD, PhD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Heart, Physician in Chief, Mount Sinai Hospital Learn more: https://medicalxpress.com/news/2018-08-cessation-options-tobacco-related-heart- disease.html
Healio: Psychiatric Annals – August 21 Sequential Amisulpride, Clozapine May Lead To Remission In Early Schizophrenia — Savannah Demko Study data showed that switching antipsychotic medications did not improve clinical outcomes in patients with first-episode schizophrenia who had not achieved remission. Instead, the findings published in The Lancet Psychiatry indicated that achieving remission in the early stages of schizophrenia was possible for most patients using a treatment system comprising the sequential use of amisulpride and clozapine. “In clinical practice, when a patient has not responded to the initial treatment, they are often switched from one antipsychotic medication to another; however, there is surprisingly little evidence that this treatment switch improves clinical outcomes,” wrote Rene S. Kahn, MD, PhD, Esther and Joseph Klingenstein Professor and system chair of psychiatry at the Icahn School of Medicine at Mount Sinai. “One of the most relevant questions in the treatment of the early phase of schizophrenia — and essential to any treatment algorithm — is whether switching to another antipsychotic improves outcome when a patient has not responded to the initial treatment is clinically useful.” - Rene S. Kahn, MD, PhD, Esther and Joseph Klingenstein Professor, System Chair, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/psychiatry/schizophrenia/news/online/%7Bbe403188-c0e5-4bc8- 95ce-e7cd155d0fad%7D/sequential-amisulpride-clozapine-may-lead-to-remission-in-early-schizophrenia
MedPage Today – August 21 The 1.2 Second Diagnosis — Judy George An artificial intelligence platform designed to spot acute neurological events like stroke, hemorrhage, and hydrocephalus identified disease in cranial images in 1.2 seconds, researchers from the Icahn School of Medicine at Mount Sinai reported. - Eric Oermann, MD, Instructor, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/neurology/generalneurology/74667#
NBC News Better – August 21 Have A Bad Back? Here’s How To Move Past The Fear Of Exercise— Vivian Manning-Schaffel Back pain is an epidemic: According to the American Association of Neurological Surgeons, as many as 80 percent of Americans will experience some form of low back pain in their lives, and, in a large survey, more than a quarter of adults reported having lower back pain in the past three months. If you’ve suffered a back injury, you know it can be terrifying to resume any kind of exercise routine. “I think there’s a lot of hesitation because of the pain and worry of reinjuring the spine,” said Joseph Herrera, DO, professor and system chair of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai. “Once you have had an episode of back pain, you’re four times more likely to have a re-occurrence.” Yet, Dr. Herrera says the worst thing you can do is lay in bed until the pain completely subsides. “Bed rest is the worst thing you can do for back pain. Resuming activity helps to release endorphins (feel-good hormones) that minimize pain, boost your mood and speed your recovery,” he explained. - Joseph Herrera, DO, Professor and System Chair, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnews.com/better/health/have-bad-back-here-s-how-move-past-fear- exercise-ncna902541
Reader’s Digest – August 21 50 Weight-Loss Breakthroughs Your Doctor Wishes You Knew— Denise Mann, MS Studies out of the Children’s Environmental Health Center at Mount Sinai have found links between everyday chemicals called phthalates and obesity. Phthalates are found in fragrances, vinyl flooring, shower curtains, and more. “Research has shown that exposure to these everyday chemicals impair childhood neurodevelopment, but this is the first evidence demonstrating that they may contribute to childhood obesity,” said the study’s lead author, Susan Teitelbaum, PhD, research professor in environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. “This study also further emphasizes the importance of reducing exposure to these chemicals where possible.” There are other household items that may be causing your weight gain. - Susan L. Teitelbaum, PhD, Research Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/diet-weight-loss/weight-loss-breakthroughs/
Prevention – August 21 How To Get Rid Of Your Runny Nose — Cassie Shortsleeve While there are surgeries for vasomotor rhinitis (chronic runny nose), there are steps you can take to reduce the flow on your own in most cases. Here, seven common reasons your nose won’t stop running —and how to turn the faucet off. If you have a fever, can’t-get-out-of-bed tiredness, a cough, congestion, or a thicker, yellow/green discharge running from your nose, your “cold” might actually be a sinus infection, which can crop up when bacteria cause irritation, infection, and discharge, said Anthony Del Signore, MD, director of rhinology and endoscopic skull base surgery at Mount Sinai Union Square. With a sinus infection, you could also notice post-nasal drip, when mucus drains to the back of your throat. Your nose can also become runny if it’s exposed to an irritant. If you’ve been leaking for more than a week and notice your goop is starting to get thicker or looks yellow or green, make an appointment. Allergies can sometimes morph into sinus infections. - Anthony Del Signore, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Rhinology and Endoscopic Skull Base Surgery, Mount Sinai Union Square Learn more: https://www.prevention.com/health/a22776525/how-to-stop-runny-nose/
Prevention – August 21 Five Things All Women Should Know About HPV— Cassie Shortsleeve You’ve likely heard of the human papillomavirus, or HPV for short. It’s a group of more than 150 viruses, some of which can lead to cervical or head and neck cancers. But what you likely don’t realize, it’s entirely possible that HPV has passed through your body. “HPV is by far and away the most common STD. About 80 percent of us are exposed to it in our lifetime,” said Brett Miles, MD, associate professor of otolaryngology, head and neck surgery at the Icahn School of Medicine at Mount Sinai and co-chief of the division of head and neck surgery for the Mount Sinai Health System. “HPV causes an abnormal growth of the squamous cells in that area,” explained Monica Prasad-Hayes, MD, a gynecologic oncologist at the Mount Sinai Health System. In fact, those warts that pop up on your hands or feet are also caused by HPV. - Brett A. Miles, MD, Associate Professor, Otolaryngology, Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Co-Chief, Division of Head and Neck Oncology, Fellowship Director, Otolaryngology-Head and Neck Surgery, Mount Sinai Health System - Monica Prasad-Hayes, MD, Associate Professor, Obstetrics, Gynecology, Reproductive Science, Icahn School of Medicine at Mount Sinai, Gynecologic Oncologist, Mount Sinai Health System Learn more: https://www.prevention.com/sex/a22778161/hpv-symptoms-women/
Washington Post – July 31 Our Worst Nightmare’: ESPN’s Samantha Ponder Describes Her Newborn Daughter’s Emergency Surgery — Cindy Boren Samantha and Christian Ponder’s infant daughter is recovering after a “series of terrifying and sudden events” required that she have emergency surgery. Price Ponder, whose birth had been announced July 21, was taken last week to Mount Sinai Hospital where a surgery took place in the middle of the night. “Thanks to the incredible surgical team at the Mount Sinai Hospital and their skill and decisiveness, our precious girl made it. They treated her like their own, and answered all our blubbering fearful questions. Her recovery in the NICU was nothing short of miraculous for a tiny body that had just undergone such trauma. I cannot thank the women who cared for her day and night enough.” - The Mount Sinai Hospital Learn more: https://www.washingtonpost.com/news/early-lead/wp/2018/07/31/our-worst-nightmare- espns-samantha-ponder-describes-her-newborn-daughters-emergency-surgery/? noredirect=on&utm_term=.489d1e0c7e63
Babble – August 21 15-Year-Old and NBA Star Team Up in Their Shared Fight Against Crohn’s Disease — Wendy Wisner Life doesn’t always go according to plan, as anyone who’s ever faced a chronic illness before will tell you. But for 15-year-old Noah Weber, who was diagnosed with Crohn’s disease just a few years ago, that doesn’t mean you give up the fight. Recently, the teen from Westchester, New York took his difficult diagnosis and turned it around in an amazing way, connecting with a famous basketball star who shares the same illness, and forming a charity to help educate and fight the disease. After undergoing testing by doctors at Kravis Children’s Hospital at Mount Sinai, Noah was officially diagnosed with Crohn’s disease in April of 2015. The diagnosis was a relief, because it meant that Noah now could get treatment and begin to feel better. - Kravis Children’s Hospital at Mount Sinai Learn more: https://www.babble.com/entertainment/larry-nance-jr-noah-weber-crohns-disease/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 23, 2018 Date: Thursday, August 23, 2018 2:39:31 PM Attachments: ATT00001.txt
In the News August 23, 2018
Cardiovascular Business – August 22 Averting Contrast Fails To Limit AKI After Coronary Angiography — Daniel Allar The Avert system successfully reduced contrast media volume but failed to trim the risk of acute kidney injury (AKI) following coronary angiography, according to a trial published in JACC: Cardiovascular Interventions. “Despite the absent effect on CI-AKI, CMV reduction is in general desirable and may be safely accomplished with the easy to use Avert system at low cost,” wrote lead author Roxana Mehran, MD, professor of medicine, cardiology, and director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai and colleagues. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.cardiovascularbusiness.com/topics/coronary-intervention-surgery/averting- contrast-angiography-doesnt-limit-aki
Jornal Dia Dia – August 22 Study Finds That Amgen's Repatha® (Evolocumab) Reduces Bad Cholesterol In Patients With Type 2 Diabetes — Daniel Susumura dos Santos Data presented at the American Diabetes Association (ADA) congress show that Repatha ® (evolocumab) helped 84.5% of patients with type 2 diabetes and high cardiovascular risk to reduce levels of bad cholesterol (LDL-C) below the current recommendation of 70mg / dL. "Diabetes is one of the major controllable risk factors for cardiovascular disease, and many patients demonstrate poor control of LDL cholesterol and non-HDL cholesterol despite treatment with statins," said Robert S. Rosenson, MD, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and lead investigator of the BANTING study. "These data are important because they demonstrate that additional treatment options, such as Repatha ® , can help further reduce bad cholesterol in patients who cannot achieve their goals with high-statin therapy alone." - Robert S. Rosenson, MD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai Learn more: http://jornaldiadia.com.br/2016/?p=477226
WSAU Radio – August 21 Small Effects From Millions Of Genes May Add Up To New Risk-Screening Tool — Cheryl Platzman Weinstock Subtle variations in millions of genes contribute to individual risk for common illnesses like heart disease and diabetes - and putting them all together into a "polygenic" risk profile can identify many more people with higher than average odds of getting sick, researchers say. These genes, which produce observable effects only in concert with other genes, are called polygenes. In a test using data from nearly half a million people with genetic samples in the UK Biobank, the experimental polygenic screening tool identified 20 times more people with a heightened risk for coronary artery disease than current single- gene tests would predict, for example. Experts not involved in the study said the test raises important questions about how it should be further developed and used. "I'm an advocate for this and I'm a fan . . . . What it takes to put this test into clinical practice will still take a bit of work," said Eric Schadt, MD, dean of precision medicine and professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai , in a telephone interview. - Eric E. Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://wsau.com/news/articles/2018/aug/21/small-effects-from-millions-of-genes-may-add- up-to-new-risk-screening-tool/
Globo – August 22 The Controversy In The US For Approving A Mobile App As A Contraceptive Method The Food and Drug Administration in the United States has recently given permission to use Natural Cycles, a Swedish cell phone application that says it will prevent pregnancy. It is the first time in history that the FDA recognizes an application as a contraceptive method. For experts, the decision has the potential to boost the so-called "femtech," the emerging industry of women's health technologies, which has seen a turnover of about $ 1 billion over the last three years. Laura MacIsaac, MD, associate professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai said, “that such a method tends to fail because its use does not always coincide with the dynamics of daily life of women.” - Laura MacIsaac, MD, Associate Professor, Medical Education, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://g1.globo.com/ciencia-e-saude/noticia/2018/08/22/a-polemica-nos-eua-pela-aprovacao- de-um-app-para-celular-como-metodo-anticoncepcional.ghtml
Bustle – August 21 Sleeping With Your Contacts In Can Lead To These Scary Injuries, A New CDC Report Says — Carolyn de Lorenzo Dozing off with our contact lenses in is all too easy sometimes, especially after a long day. But sleeping with your contacts in is actually super dangerous. The Centers for Disease Control (CDC) issued a report on August 16, 2018 stating that folks who sleep with their contacts in are six to eight times more likely to develop corneal infections than those who don’t. Cornea specialists agree that sleeping in contact lenses is dangerous, and places one at high risk for infections. Sumayya Ahmad, MD, cornea surgeon at the New York Eye and Ear Infirmary of Mount Sinai tells Bustle via email. Dr. Ahmad further explains that the best way to protect your eyes long-term is to either wear daily disposable lenses, or take them out before sleeping and clean and disinfect them well. And always make sure to ditch your lenses by their expiration date. - Sumayya Ahmad, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://www.bustle.com/p/sleeping-with-your-contacts-in-can-lead-to-these-scary-injuries-a- new-cdc-report-says-10186003
Allure – August 22 How to Tell If Your Skin Is Dry or Dehydrated, According to Experts — Allison Duncan For dry skin, there are a number of ways to soothe parched complexions (i.e. amping up your antioxidant intake and reducing the number of acids in your routine). Dehydration, on the other hand, is a different story. While hydration is key if you're suffering from dehydrated skin, there are a few other at-home treatment options to consider, too. "My favorite tip is exfoliating," says Francesca J. Fusco, MD, an assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. "As dead skin builds up, it can diminish the absorption of moisturizers." She recommends exfoliating at least once a week to remove dead skin cells, which "allows your moisturizer to work better." - Francesca J. Fusco, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.allure.com/story/dry-vs-dehydrated-skin-whats-the-difference
Onc Live – August 22 Dr. Galsky Discusses Neoadjuvant Immunotherapy in Bladder Cancer — Matthew Galsky, MD Matthew Galsky, MD, professor of medicine, hematology, and medical oncology, Icahn School of Medicine at Mount Sinai, discusses neoadjuvant immunotherapy in bladder cancer. Immunotherapy, specifically checkpoint inhibitors, have exploded onto the scene of bladder cancer in the last few years. Dr. Galsky says that there may be a role for immunotherapy in the neoadjuvant setting of muscle- invasive bladder cancer (MIBC). There are currently multiple single-arm trials assessing immune checkpoint blockade in the neoadjuvant setting for these patients. Historically, chemotherapy has been the standard neoadjuvant therapy followed by cystectomy in patients with cisplatin-eligible MIBC. For patients with MIBC who are not eligible for cisplatin, there is currently no standard preoperative therapy, and these patients are treated with surgery alone, Dr. Galsky says. - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Icahn School of Medicine at Mount Sinai Learn more: https://www.onclive.com/onclive-tv/dr-galsky-discusses-neoadjuvant-immunotherapy-in- bladder-cancer
Onc Live – August 22 Dr. Madduri on Eligibility for CAR T-Cell Therapy in Myeloma — Deepu Madduri, MD Deepu Madduri, MD, assistant professor, Icahn School of Medicine at Mount Sinai, discusses eligibly criteria for patients with multiple myeloma to receive chimeric antigen receptor (CAR) T-cell therapy.There have been very promising data published recently on the use of CAR T-cell therapy for patients with myeloma, says Dr. Madduri. The anti-BCMA CAR T-cell therapy bb2121 was granted a breakthrough therapy designation for previously treated patients with relapsed/refractory myeloma in November 2017. - Deepu Madduri, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.onclive.com/onclive-tv/dr-madduri-on-eligibility-for-car-tcell-therapy-in- myeloma
U.S. News & World Report – August 22 How Can I Find the Best Endocrinologist? — Elaine K. Howley When it comes time to find an endocrinologist, it's important to look for a doctor who has expertise or experience treating your specific condition. "A primary care physician is a good place to begin," says Rachel Pessah-Pollack, MD, assistant clinical professor of medicine, endocrinology, diabetes and bone disease at the Mount Sinai Hospital in New York, "because they can often point you in the right direction." She says patients will sometimes come to her "and they're not sure why they're there. That leads to frustration," especially if it turns out they need to see a different doctor with more expertise in a specific area. - Rachel Pessah-Pollack, MD, Assistant Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Mount Sinai Hospital Learn more: https://health.usnews.com/health-care/patient-advice/articles/2018-08-22/how-can-i-find-the- best-endocrinologist
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 24, 2018 Date: Friday, August 24, 2018 1:38:30 PM Attachments: ATT00001.txt
In the News August 24, 2018
News Medical – August 24 Researchers Find New Therapy To Prevent Drug Resistance For Melanoma Patients — Alina Shrourou Mount Sinai researchers have discovered a previously unknown reason for drug resistance in a common subtype of melanoma, one of the deadliest forms of cancer, and in turn, have found a new therapy that could prevent or reverse drug resistance for melanoma patients with a particular gene mutation, according to a study published in Nature Communications in August. The incidence of cutaneous malignant melanoma is rising and its therapeutic management remains challenging," said lead researcher Emily Bernstein, PhD, associate professor of oncological sciences and dermatology at the Icahn School of Medicine at Mount Sinai. - Emily Bernstein, PhD, Associate Professor, Oncological Sciences, Dermatology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180824/Researchers-find-new-therapy-to-prevent- drug-resistance-for-melanoma-patients.aspx Additional coverage: Genetic Engineering and Biotechnological News: https://www.genengnews.com/gen-news- highlights/melanoma-drug-resistance-mechanism-and-biomarker-identified/81256168
Health Analytics – August 24 Deep Learning IDs Neurological Scans 150 Times Faster than Humans — Jessica Kent Researchers at Mount Sinai Icahn School of Medicine at Mount Sinai developed a platform designed to identify acute neurological conditions, including stroke, hemorrhage, and hydrocephalus, detected disease in CT scans in 1.2 seconds, or 150 times faster than human radiologists. This study is the first to use artificial intelligence to detect a wide range of acute neurological events and to demonstrate a direct clinical application. “The application of deep learning and computer vision techniques to radiological imaging is a clear imperative for 21st century medical care,” said Burton Drayer, MD, Charles M. and Marilyn Newman Professor and System Chair of the Department of Radiology for the Mount Sinai Health System, CEO of the Mount Sinai Doctors Faculty Practice, and Dean for Clinical Affairs of the Icahn School of Medicine. “The expression ‘time is brain’ signifies that rapid response is critical in the treatment of acute neurological illnesses, so any tools that decrease time to diagnosis may lead to improved patient outcomes,” said Joshua Bederson, MD, Professor and System Chair for the Department of Neurosurgery at Mount Sinai Health System and Clinical Director of the Neurosurgery Simulation Core. - Joshua Bederson, MD, Professor, System Chair, Department of Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core - Burton Drayer, MD, Chair, Department of Radiology, Mount Sinai Health System, Charles M. and Marilyn Newman Professor and Dean for Clinical Affairs, Icahn School of Medicine at Mount Sinai; CEO, Mount Sinai Doctors Faculty Practice Learn more: https://healthitanalytics.com/news/deep-learning-ids-neurological-scans-150-times-faster- than-humans
Crain’s Health Pulse – August 24 Manhattan Eye Care Practice To Expand To East Harlem — Jonathan LaMantia Union Square Eye Care, a private ophthalmology practice, plans to open shop uptown. The new location will offer comprehensive eye care services ranging from routine exams to treatment of glaucoma and retinal disease. Physicians will perform surgeries at hospitals such as the Mount Sinai Hospital and New York Eye and Ear Infirmary. - New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180824/PULSE/180829932/manhattan-eye-care- practice-to-expand-to-east-harlem
Healthline – August 23 4 Ways Massage Can Boost the Effectiveness of Your Workouts A 2015 study found that massage “increases the percentage of regenerating muscle fibers,” especially when done immediately after exercise. Melissa Leber, MD, assistant professor of orthopedics and emergency medicine at the Icahn School of Medicine at Mt. Sinai, and director of Emergency Department Sports Medicine, said massage can be an essential tool for the recovery time between intense workouts. “When you’re training really hard — for example, like a U.S. Open athlete — you’re trying not only to stay motivated and driven, but you’re also trying to recover in between these hard workouts,.” However, Dr. Leber, who’s been a player physician for the U.S. Open medical services annually since 2014, pointed out that the benefits of massage can help with recovery after workouts for people at all levels of fitness. - Melissa Leber, MD, Assistant Professor, Orthopedics, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Department Sports Medicine, Mount Sinai St. Luke’s, Mount Sinai West Learn more: https://www.healthline.com/health-news/massage-can-boost-effectiveness-of-workouts
Omaha World Press – August 24 The FDA Approved An App To Prevent Pregnancy. Can An App Do That? — Rachel Siegel An FDA-approved app entitled, Natural Cycles became the first app approved by the government to prevent pregnancy. The Swedish-based company had been cleared in Europe in 2017 and is an emerging name within the "Femtech" industry — a catch-all for "female health technology" that has reaped an estimated $1 billion of investment worldwide in the past three years. Laura MacIsaac, MD, associate professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai, said Natural Cycles was "a little more exciting" in that it tracks both menstrual calendars and basal body temperature. - Laura MacIsaac, MD, Associate Professor, Medical Education, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.omaha.com/livewellnebraska/health/the-fda-approved-an-app-to-prevent- pregnancy-can-an/article_0d966178-eacb-5fbe-a403-b88e31ab8ea8.html
The Cut – August 22 My Doctor Says My Chest Pain Is Just Anxiety, But I’m Not So Sure — Katie Heaney The question is: is there something wrong with my heart? Maryann McLaughlin, MD, associate professor of cardiology and Medical Director of the Cardiac Health Program at Mount Sinai Hospital, says some heart and chest pains are a cause for concern — but there are others that you really can (try to!) ignore. When symptoms were described to Dr. McLaughlin, she thinks it’d be worthwhile for you to see a cardiologist (NOT because she’s worried, so don’t panic!). Mostly, this would be for your own peace of mind. “If you’ve had these types of symptoms, it’s worth seeing a cardiologist at least once to get checked out, even though the chances of a heart attack are very low. - Maryann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co-Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.thecut.com/2018/08/is-my-chest-pain-anxiety-or-something-more-serious.html
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From: ITNDaily Subject: Mount Sinai In The News - August 27, 2018 Date: Monday, August 27, 2018 12:26:17 PM Attachments: ATT00001.txt
In the News August 27, 2018
Science Daily – August 24, 2018 Epigenetic Reason For Drug Resistance Discovered In A Deadly Melanoma Mount Sinai researchers have discovered a previously unknown reason for drug resistance in a common subtype of melanoma, one of the deadliest forms of cancer, and in turn, have found a new therapy that could prevent or reverse drug resistance for melanoma patients with a particular gene mutation, according to a study published in Nature Communications in August. "The incidence of cutaneous malignant melanoma is rising and its therapeutic management remains challenging," said lead researcher Emily Bernstein, PhD, associate professor of oncological sciences and dermatology at the Icahn School of Medicine at Mount Sinai. - Emily Bernstein, PhD, Associate Professor, Oncological Sciences, Dermatology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.sciencedaily.com/releases/2018/08/180824090608.htm Additional coverage: News Medical: https://www.news-medical.net/news/20180824/Researchers-find-new-therapy-to-prevent- drug-resistance-for-melanoma-patients.aspx Genetic Engineering and Biotechnological News: https://www.genengnews.com/gen-news- highlights/melanoma-drug-resistance-mechanism-and-biomarker-identified/81256168 RD Magazine: https://www.rdmag.com/news/2018/08/researchers-discover-epigenetic-reason-drug- resistance-deadly-melanoma
Spine Universe – August 24 Magnetic Kyphoplasty May Optimize Drug Delivery in Spinal Compression Fractures — Samuel K. Cho, MD Magnetic kyphoplasty has the potential to provide targeted drug therapy, according to Samuel K. Cho, MD, chief of spine surgery at Mount Sinai West, director of spine surgery fellowship, and associate professor in the department of orthopedic surgery and neurosurgery at the Icahn School of Medicine at Mount Sinai. “This is a proof-of-concept animal study that has demonstrated potential benefits of a new technology. There still needs to be a lot of work done to prove both safety and efficacy in humans,” says Dr. Cho. “I am excited to see further development of this technology in the future.” - Samuel K. Cho, MD, Chief, Spine Surgery at Mount Sinai West, Director of Spine Surgery Fellowship, and Associate Professor in the Department of Orthopedic Surgery and Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.spineuniverse.com/professional/news/magnetic-kyphoplasty-may-optimize- drug-delivery-spinal-compression-fractures
TCT MD – August 27 Global Leaders: Ticagrelor Monotherapy Fails To Beat Conventional DAPT After PCI — Michael O'Riordan Dropping aspirin after 1 month and continuing monotherapy with ticagrelor is no better than standard dual antiplatelet therapy (aspirin plus ticagrelor or clopidogrel) among patients undergoing PCI for ACS or stable coronary artery disease, according to the results of the Global Leaders study. Optimal antiplatelet therapy after PCI remains far from a settled question. That strategy is being tested in the ongoing TWILIGHT trial, which is being led by Roxana Mehran, MD, professor of medicine, cardiology, and director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. Through the study, which will include approximately 9,000 patients, investigators are testing a strategy of ticagrelor monotherapy versus dual antiplatelet therapy with aspirin and ticagrelor. Patients will be switched to ticagrelor monotherapy after completing a 3-month course of ticagrelor and aspirin. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/global-leaders-ticagrelor-monotherapy-fails-beat- conventional-dapt-after-pci
Insight – August 22 Congenitally Blind Mice Have Vision Restored — Matthew Woodley Scientists have restore vision in congenitally blind mice by changing Müller glia in their retina into rod photoreceptors. “From a practical standpoint, if you’re trying to regenerate the retina to restore a person’s vision, it is counterproductive to injure it first to activate the Müller glia. We wanted to see if we could program Müller glia to become rod photoreceptors in a living mouse without having to injure its retina,” said Bo Chen, PhD, associate professor of ophthalmology and director of the Ocular Stem Cell Program at the Icahn School of Medicine at Mount Sinai said - Bo Chen, PhD, Associate Professor, Ophthalmology, Director, Ocular Stem Cell Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.insightnews.com.au/Article3/1789/Congenitally-blind-mice-have-vision-restored
Healthcare Dive – August 24 Three-Fourths Of Business Leaders See 'Compelling' Case For Blockchain — Meg Bryant Interest in blockchain is high, and companies don't want to be left behind if valid use cases are identified. Nearly 40 percent of respondents say their organization will invest at least $5 million in blockchain technology over the next year. The Institute for Next Generation Healthcare and Icahn School of Medicine at Mount Sinai have established a new research center devoted to exploring potential applications for blockchain in healthcare and medical science. - Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthcaredive.com/news/three-fourths-of-business-leaders-see-compelling- case-for-blockchain/530876/
Healthline – August 21 Can Emsculpt Help You Get the Abs You’ve Always Wanted? — Julia Ries Approved by the U.S. Food and Drug Administration (FDA), Emsculpt increases muscle mass by 16 percent and reduces the waistline by approximately 19 percent, according to the company. “CoolSculpt is typical for more fat loss, Emsculpt more for muscle toning,” said Liviu-Bruno Saimovici, MD, clinical instructor at the Mount Sinai Hospital. - Liviu-Bruno Saimovici, MD, Clinical Instructor, The Mount Sinai Hospital Learn more: https://www.healthline.com/health-news/can-emsculpt-help-you-get-the-abs-youve-always- wanted
Everyday Health – August 24 Eosinophilic Asthma: What It Is, How It’s Treated, and More From Dr. Neil Schachter of Mount Sinai You may have heard it on TV, in a magazine, or from your doctor — eosinophilic asthma is one of the latest buzzes in the pulmonology field. Here’s what you need to know about this subtype of asthma. Eosinophilic (pronounced e-uh-sin-uh-fil-ic) asthma is a subtype of asthma and because of newly available treatments that target eosinophils, a type of white blood cell, there’s excitement about it both among physicians and among patients who’ve previously struggled to control their symptoms. Neil Schachter, MD, professor of medicine, pulmonary, critical care and sleep medicine, pediatrics, preventive medicine, environmental medicine and public health at the Icahn School of Medicine at Mount Sinai answers several questions regarding eosinophilic asthma. - Neil E. Schachter, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Pediatrics, Preventive Medicine, Environmental Medicine and Public Heath, Icahn School of Medicine at Mount Sinai Learn more: https://www.everydayhealth.com/solutions/stories/eosinophilic-asthma-faqs/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200
From: ITNDaily Subject: Mount Sinai In The News - August 28, 2018 Date: Tuesday, August 28, 2018 2:03:21 PM Attachments: ATT00001.txt
In the News August 28, 2018
Technology Networks – August 28 Novel Epigenetic Mechanism For Drug Resistance In A Deadly Melanoma Mount Sinai researchers have discovered a previously unknown reason for drug resistance in a common subtype of melanoma, one of the deadliest forms of cancer, and in turn, have found a new therapy that could prevent or reverse drug resistance for melanoma patients with a particular gene mutation, according to a study published in Nature Communications. "The incidence of cutaneous malignant melanoma is rising and its therapeutic management remains challenging," said lead researcher Emily Bernstein, PhD, associate professor of oncological science and dermatology at the Icahn School of Medicine at Mount Sinai. "In recent years, there has been extensive therapeutic development to inhibit key biological targets. Although a large proportion of patients with advanced metastatic melanoma harboring BRAF mutations respond to the standard therapy, known as MAPK inhibitors, subsequent resistance remains a major clinical challenge." - Emily Bernstein, PhD, Associate Professor, Oncological Sciences, Dermatology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.technologynetworks.com/cancer-research/news/novel-epigenetic-mechanism- for-drug-resistance-in-a-deadly-melanoma-308126
Harvard Magazine – September/October Issue Renowned Transplant Hepatologist John Bucuvalas, MD, Joins Mount Sinai John Bucuvalas, MD, has been named professor, vice chair of faculty affairs and chief of the division of hepatology in the Clark department of pediatrics at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Kravis Children’s Hospital. He will also serve as director of solid organ transplant outreach for the Recanati/Miller Transplantation Institute at Mount Sinai. Dr. Bucuvalas specializes in pediatric transplant hepatology. - John Bucuvalas, MD, Professor, Vice Chair, Faculty Affairs, Chief, Division of Hepatology, Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Solid Organ Transplant Outreach, Recanati / Miller Transplantation Institute, The Mount Sinai Hospital Learn more: http://harvardmag.com/pdf/2018/09-pdfs/0918-HarvardMag.pdf
Newsweek – August 28 Eating This Much Chocolate Could Cut Heart Disease Risk By 13 Percent — Kashmira Gander Eating a moderate amount of chocolate could cut the risk of heart disease, a study has suggested. Researchers assessed five studies involving 575,000 individuals to conclude eating three bars of chocolate a month could lower the risk of heart disease by 13 percent from the baseline. But the study presented at the European Society of Cardiology conference in Munich isn’t a green light to eat chocolate in excess, as indulging every day appeared to raise the risk of heart failure by 17 percent. Chayakrit Krittanawong, MD, post graduate of internal medicine at the Icahn School of Medicine at Mount Sinai, who led the research, said, “I believe that chocolate is an important dietary source of flavonoids which are associated with reducing inflammation and increasing good cholesterol. Flavonoids can increase levels of nitric oxide in the body, which widens the blood vessels and can improve circulation.” But he warned many chocolate products are high in saturated fats. “Therefore, moderate consumption is recommended at this moment,” he said. Next, a randomized clinical trial is needed to definitively answer whether chocolate can boost heart health, as well as which forms of chocolate are most beneficial. - Chayakrit Krittanawong, MD, Post Graduate, Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.newsweek.com/eating-much-chocolate-cuts-heart-disease-risk-13-percent- 1092310 Additional coverage: The Telegraph https://www.telegraph.co.uk/news/2018/08/27/three-bars-chocolate-month-can-reduce- chances-heart-failure/ Insider https://www.thisisinsider.com/eating-3-bars-of-chocolate-a-month-may-reduce-risk-of-heart- disease-2018-8 USA Online Journal https://usaonlinejournal.com/2018/08/28/eating-3-bars-of-chocolate-a-month-may- reduce-the-risk-of-heart-disease-but-probably-only-if-its-dark/ Huffington Post https://www.huffingtonpost.co.uk/entry/chocolate-may-protect-your-heart-health- according-to-some-wonderful-research_uk_5b8508dbe4b0511db3d14247 tctMD – August 28 Pretreatment With P2Y12 Inhibitors Questioned Anew In SCAAR — Shelley Wood A new analysis from the large SCAAR registry in Sweden is once again challenging the role of pretreatment with oral P2Y12 receptor antagonists in PCI patients, this time zeroing in on patients with unstable angina or NSTEMI. This is the second time a SCAAR analysis has looked at the issue of P2Y12 antagonists in the pre-PCI setting. Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, who was a co-moderator for the session, pointed out that the two trials that pulled the rug out from under the PCI pretreatment both involved patients who were taken very swiftly to the cath lab. “In stable patients, I think there’s no reason not to pretreat unless you are really concerned about needing to send them to bypass surgery,” she said. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/pretreatment-p2y12-inhibitors-questioned-anew-scaar
MedPage Today – August 27 ESC: Short DAPT With Ticagrelor Doesn’t Improve Outcomes — Nicole Lou Abbreviated dual antiplatelet therapy (DAPT) with ticagrelor (Brilinta) was no better for preventing death or non-fatal MI after stenting than a standard drug regimen in the GLOBAL LEADERS trial. GLOBAL LEADERS is the largest trial yet in the interventional space to examine a strategy to simplify DAPT post-PCI, commented Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, who was not involved in the trial. "Overall, I actually think that despite missing the primary endpoint, the study is a huge milestone in our quest to improve safety and efficacy of DAPT post-PCI, and in finding ways to simplify the regimen without harming patients," Dr. Mehran said. Nevertheless, the study suffered from an open-label design that had implications for patient compliance, she said, "and this is really the biggest issue." - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/esc/74771
Metro US – August 27 How College Students Can Cope With Anxiety And Depression — Kristin Toussaint Thousands of students across the country are getting ready to go back to school. But whether they’re heading off to college for the first time or returning to campus, they might be feeling some anxiety along with their excitement. Anxiety is one of the most common mental health disorders in adolescents, said Lindsay Gerber, PsyD, clinical psychologist at the Mount Sinai Adolescent Health Center. And since college comes with a lot of expectations, changes and stressors, students often deal with mental health issues. “We see a lot of kids coming in from local colleges in the area or who have been here a couple of years and are now transitioning to go off to college,” she said. “There’s a lot of worries of ‘what’s it going to be like, am I going to fit it, how am I going to take on this new responsibility of academics and social life?’ Kids get really excited about the increased freedom, but at the same time with that freedom comes a lot of fear.” Still, the increase in students seeking services means some schools are overwhelmed when it comes to providing care. That’s where a service like the Mount Sinai Adolescent Health Center could come in. - Lindsay E. Gerber, PsyD, Assistant Professor, Pediatrics, Adolescent Medicine, Psychiatry, Icahn School of Medicine at Mount Sinai, Clinical Psychologist, Mount Sinai Adolescent Health Center Learn more: https://www.metro.us/news/the-big-stories/college-students-mental-health-resources
Nature – August 28 United States Woefully Unprepared For Nuclear Strike, Says Scientists — Sara Reardon The United States is not prepared to deal with the aftermath of a major nuclear attack, despite North Korea’s efforts to develop nuclear weapons and the increasing tensions between nations overall. That was the blunt assessment of public-health experts who participated in a meeting last week on nuclear preparedness, organized by the National Academies of Sciences, Engineering, and Medicine. The US government’s spending on nuclear-weapons research and response has dropped drastically over the past few decades — as has the number of health workers with training in radiation medicine and management. Compounding these concerns, treatments for radiation exposure and burns might not be available in sufficient quantities in the aftermath of a nuclear attack. James Jeng, MD, burn surgeon at the Mount Sinai Health System, said that the detonation of a nuclear bomb can leave behind hundreds of thousands of burn victims. The best treatment for such injuries is skin grafting, he said, but there are only about 300 burn surgeons in the United States who know how to perform the procedure. It might also be difficult to quickly transport enough donor skin to treatment sites, Dr. Jeng added. - James C. Jeng, MD, Burn Surgeon, Mount Sinai Health System Learn more: https://www.nature.com/articles/d41586-018-06077-x
HealthDay – August 27 New Wrinkle In Heart Health: Furrowed Brows May Bode Ill — Dennis Thompson A furrowed brow could be a red flag for your heart health, a new French study suggests. People who have more deep forehead wrinkles than is typical for their age might have a higher risk of dying from heart disease, researchers found. But the study did not prove that forehead wrinkles cause heart risks to rise, and other heart experts remained skeptical. "I'm not so sure I would put too much on this until we have more evidence," said Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. "To imagine this could be a risk factor for cardiovascular mortality, it would need further investigation, I think." The researchers presented the findings Sunday at the European Society of Cardiology's annual meeting, in Munich, Germany. They said they don't know why forehead wrinkles might be linked to heart disease, but they said it could be due to hardening of the arteries (atherosclerosis). - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/circulatory-system-information-7/coronary-and-artery- news-356/new-wrinkle-in-heart-health-furrowed-brows-may-bode-ill-737153.html Additional coverage: United Press International https://www.upi.com/Furrowed-brow-may-be-warning-sign-for-heart- trouble/9191535420755/ Health Magazine https://www.health.com/healthday/new-wrinkle-heart-health-furrowed-brows-may- bode-ill Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/82820 Newsline https://newsline.com/2018/08/27/contemporary-wrinkle-in-heart-health-furrowed-brows- would-possibly-maybe-presumably-bode-sick/
New York Post – August 27 Athletes Claim These Creepy Masks Boost Their Workouts — Christian Gollayan Training masks have been gaining popularity among athletes for a few years now. Gym rats are now catching on. John Serafano, marketing director of the popular brand Training Mask, says that their devices are worn by athletes and regular guys alike. Experts are dubious. For one thing, there are no published studies to back the effectiveness of these masks. It’s basically like “putting a hand over your mouth,” said Joseph Herrera, DO, professor and system chair of the department of rehabilitation and human performance at the Icahn School of Medicine at Mount Sinai. Dr. Herrera said the training at higher altitudes with reduced oxygen pressure actually can lead to stronger endurance – but that these masks don’t really mimic that effect. Dr. Herrera said that running, sans mask, is the best way to build up your lungs. “Adding mileage goals” and gradually increasing how far you run “helps your body adapt to the distance and the amount of oxygen that you’re taking in,” he said. That said, he’s had athletes who have come in and sworn by these masks’ effectiveness, and he’s not judging them for it. - Joseph Herrera, DO, Professor and System Chair, Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai Learn more: https://nypost.com/2018/08/27/athletes-claim-these-creepy-masks-boost-their-workouts/
Instinct Magazine – August 27 Journalist Karl Schmid Speaks Candidly About Stigma Of Being HIV+ — Randy Slovacek Karl Schmid, reporter for ABC7 in Los Angeles, came out as HIV+ in a candid social media post this past March. He spoke with The Today Show’s Megyn Kelly about what it was like to share his status with the world. With an upbeat tone and message, Schmid told the audience his goal in coming out was to hopefully breakdown the still-painful stigma surrounding HIV today. Antoinio Urbina, MD, associate professor of medicine and infectious disease and medical director of the Institute for Advanced Medicine at the Icahn School of Medicine at Mount Sinai, was on hand to help breakdown the stigma. “A person living with HIV takes their medications, drives their viral load down to undetectable, their chances of transmitting is zero.” Dr. Urbina said. - Antonio Urbina, MD, Associate Professor, Medicine, Infectious Disease, Medical Director, Institute for Advanced Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://instinctmagazine.com/post/journalist-karl-schmid-speaks-candidly-about-stigma- being-hiv
The Washington Post – August 27 Eye Twitches Are Usually Harmless, But Here’s What You Can Do About Them — Kate Furby Americans are spending more and more time looking at screens, and it’s not always fun or entertaining. It prevents us from hitting our bedtime goals. It fatigues our eye muscles. The exact biological reasons for the benign eye twitch remain a mystery. However, the muscle that begins to spasm is usually the orbicularis oculi, the delicate muscle fibers responsible for opening and closing the eyelid. Rudrani Banik, MD, associate professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai studied the benign eyelid twitch following 15 patients over many years. The average length of time reported for the twitch was seven years. The study defined eye twitches, or chronic myokymia, as “fine, continuous, undulating contractions” across the muscle. None of Dr. Banik's patients progressed to a neurological condition during the study, however, in rare cases, an eye twitch can be a sign of larger issues, depending on how it occurs. - Rudrani Banik, MD, Associate Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Ophthalmologist, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.washingtonpost.com/news/to-your-health/wp/2018/08/27/eye-twitches-are- usually-harmless-but-heres-what-you-can-do-about-them/?noredirect=on
Bustle – August 22 Seven Fascinating Signs Your Itchiness Is Actually A Larger Health Issue — Lauren Dana It’s common to be itchy from time to time. However, if the feeling sticks around, sometimes that itchiness can be symptoms of a larger health issue. If your itchiness is keeping you up at night, you may be suffering from eczema, which causes red patches and/or inflamed skin, said Emma Guttman, MD, PhD, director of the Center for Excellence in Eczema at the Icahn School of Medicine at Mount Sinai. “Atopic dermatitis involved an itch that disturbs sleep, it’s an itch that is very bothersome and effects a patient’s entire quality of life,” Dr. Guttman said. The only way to stop the itchiness is to decrease the skin inflammation. To do this, speak with your dermatologist or doctor to see which course of treatment is right for you. - Emma Guttman, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.bustle.com/p/7-fascinating-signs-your-itchiness-is-actually-a-larger-health- issue-10175542
Bravo – August 27 How to Keep Your Skin Clear and Glowing All Summer Long — Chantel Morel Hot summer days can wreak havoc on your skin. This wonderful time of the year filled with outdoor adventures just may be the culprit behind those recent blemishes on your face. “Hot weather means that we are sweating more than we do during other times in the year. Plus, humidity can trap oil and dirt on the skin leading to breakouts in some people. How does one begin to tackle this beauty concern? Building a proper skincare regimen as well as taking care of your skin from the inside out by making healthier lifestyle choices is certainly a great start,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: http://www.bravotv.com/lookbook/how-to-prevent-summer-breakouts
Self Magazine – August 27 Here’s What Dry Brushing Your Skin Actually Does, And Doesn’t Do — Jenn Sinrich “Dry brushing is the process of using a brush with stiff bristles against the skin to help exfoliate dead cells from the skin surface and enhance blood flow,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. “Typically, the brushes that are used have long, natural bristles that offer firm resistance against the skin and long handles so that they can be used even on hard to reach areas like the back.” The “dry” part of dry brushing refers to the fact that neither the brush nor your skin should be damp while you do it. Among other purported benefits, dry brushing is said to increase drainage of lymphatic fluids, thereby flushing toxins from the body. There’s not much truth to this concept. For one thing, your body handles its own detoxification. “The only detoxifying organs in the body are the liver and the kidneys,” said Dr. Zeichner. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.self.com/story/what-dry-brushing-your-skin-actually-does
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 29, 2018 Date: Wednesday, August 29, 2018 2:27:40 PM Attachments: ATT00001.txt
In the News August 29, 2018
The New York Times – August 28 Who Should Pay For Medical School? — David Muller, MD In focusing on societal need, we should be providing relief for students who pursue primary care in underserved communities. We could add to that careers in global health, public service and health services research. In recent decades the socioeconomic demographic of medical students has changed. Today up to a third of medical students in some schools come from families that don’t even bother applying for financial aid. These families have the resources to pay for medical school outright. “Regardless of whether these students are interested in pursuing primary care or a surgical subspecialty, they won’t be saddled with debt, and probably shouldn’t be the recipients of scarce financial aid dollars. In addition to aligning debt relief with societal need, I would make the case that families that can pay, should pay,” said David Muller, MD, dean of medical education, professor of medicine and medical education at the Icahn School of Medicine at Mount Sinai and chair of medical education for the Mount Sinai Health System. - David Muller, MD, Dean, Medical Education, Professor, Medicine, Medical Education, Icahn School of Medicine at Mount Sinai, Chair, Medical Education, Mount Sinai Health System Learn more: https://www.nytimes.com/2018/08/28/opinion/letters/nyu-medical-school-tuition.html
CBS New York – August 28 New Treatments Offer Hope For Advanced-Stage Breast Cancer Patients — Dr. Max Gomez Many of the over 150,000 American women with advanced-stage breast cancer are living longer thanks in part to new treatments being tested to try and beat the disease. While there’s still no cure if it metastasizes, the new treatments are increasing survival significantly and with much better quality of life. 29-year-old Morgan Mitchell and her fiance hit the gym five days a week. She has four marathons under her belt, works at least 60 hours a week, and travels for her job. She does all of it while battling stage-four breast cancer. Her oncologist, Paula Klein, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, suggested she enroll in a new clinical trial for metastatic breast cancer patients. The experimental treatment combines four different targeted drugs to try to stop cancer cells from growing and spreading. “This is the new way to treat cancer,” Dr. Klein said. “Going after the unique biology of every cancer is the answer.” Mount Sinai is the first and only hospital offering this particular trial which allows patients to avoid chemotherapy and radiation. It’s allowed Morgan to main a reasonable quality of life. - Paula Klein, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://newyork.cbslocal.com/2018/08/28/advanced-stage-breast-cancer-new-treatments/
Cancer Network – August 28 An Integrative Multiomics Approach To Multiple Myeloma — John Schieszer When practicing precision oncology for multiple myeloma, clinicians currently match specific DNA mutations to the optimal targeted therapy. However, it may be time to think about incorporating genome- wide RNA profiles to better guide therapy. A new trial published in JCO Precision Oncology found that a comprehensive RNA and DNA sequencing platform may benefit late-stage and drug-resistant multiple myeloma patients by determining which agents may work best for them. “Our study demonstrated that tumor sequencing can help guide treatment decisions patients with relapsed/refractory multiple myeloma in a personalized manner. What was surprising was that the majority of patients who responded to the recommended treatment were treated based on their RNA expression, rather than on their DNA mutations,” said study investigator Alessandro Lagana, PhD, an assistant professor of genetics and genomic sciences at the Institute for Next Generation Healthcare and the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai. - Alessandro Lagana, PhD, Assistant Professor, Genetics and Genomic Sciences, The Institute for Next Generation Healthcare, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai Learn more: http://www.cancernetwork.com/multiple-myeloma/integrative-multiomics-approach-multiple- myeloma
OZY – August 29 Sperm Counts Have Dropped 50 Percent. Can She Find A Fix? — Marissa Fessenden When a team of researchers at the Icahn School of Medicine at Mount Sinai paged through thousands of scientific studies on human fertility published from 1981-2013, they discovered something shocking: The average sperm count for men in Western countries had dropped by 50 to 60 percent, and so far, experts remain at a loss as to how to treat this potential male fertility crisis. Part of the problem is that not many researchers study male fertility, owing to poor funding and the complexity of the issue. The global fertility industry pulls in approximately $16.7 billion a year, and about 1 in 7 couples worldwide struggle with infertility. It’s a problem, though, that has long been considered a woman’s health issue, despite the fact that in roughly 50 percent of cases, male fertility is the source of the trouble. Even so, when data shows a steep decline in sperm counts, researchers speculate that environmental factors, such as exposure to pollutants, are to blame, but they’re not sure what’s causing the decline or what to do about it. - Icahn School of Medicine at Mount Sinai Learn more: https://www.ozy.com/rising-stars/sperm-counts-have-dropped-50-percent-can-she-find-a- fix/88573
MedPage Today – August 28 ESC: DCD Works For De Novo Stenoses In Small Coronary Vessels — Nicole Lou A drug-coated balloon (DCB) was on par with second-generation stents for use in native vessels measuring 2-3 mm in diameter, a randomized non-inferiority trial showed. The trial sets the stage for larger studies in truly small vessels (<2.5 mm) for which there are no dedicated devices and disproportionately affect women and patients with diabetes, according to ESC session discussant, Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. Dr. Mehran pointed out that those groups were surprisingly still underrepresented in the trial. In addition, vessel size should have been evaluated angiographically, she said, not with operator assessment. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/esc/74806 tctMD – August 28 Too Little, Too Late? Absorb BVS Shows Promising Results In STEMI Patients— Michael O’Rlordan It might be “too little, too late,” but a small study suggests the Absorb bioresorbable scaffold, formerly from Abbott, might actually be effective in STEMI patients. Although investigators caution the study was short in duration and utilized an angiographic endpoint, the Absorb scaffold performed as well as the everolimus- eluting stent with respect to the primary endpoint of lesion diameter stenosis at 6 to 8 months. Other measures, such as late lumen loss and target lesion revascularization, were also not significantly different between the two treatment strategies. Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, who moderated the interventional session where the trial was presented, said the “results were excellent for a bioresorbable scaffold.” - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/too-little-too-late-absorb-bvs-shows-promising-results-stemi- patients tctMD – August 28 BASKET-SMALL 2: Drug-Coated Balloon Fares Well Against DES For De Novo Small-Vessel Disease — Todd Neale In patients with de novo lesions in small coronary arteries, a drug-coated balloon (DCB) provides results similar to those obtained with second-generation DES after successful predilatation, according to the BASKET-SMALL 2 noninferiority trial. Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, who served as a discussant at a Hot Line Session at ESC, agreed that the trial is not definitive. She highlighted several issues, including questions about the size of the vessels included in the study because of the lack of confirmation with an angiographic core lab assessment; questions about the size and number of devices used in each arm; the use of the Taxus Element stent in some of the patients; and the possibility of selection bias stemming from the long, roughly 5-year enrollment period. I’m not so clear if we actually are showing noninferiority because of the patients who are included in the trial,” she said. “But I think it really sets the stage for a head-to-head evaluation of DES versus drug-coated balloons in patients with truly small-vessel, diffuse disease, because I do think there is a very important opportunity for us to treat these patients.” - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.tctmd.com/news/basket-small-2-drug-coated-balloon-fares-well-against-des-de- novo-small-vessel-disease
US News & World Report – August 28 Food For Thought: Diet May Be The Top Way To Influence How Your Brain Ages— Courtney Rubin A 2018 study suggests diet may be the number one way to influence how your brain ages, compared to other lifestyle factors such as exercise and intellectual-enrichment activities. And starting in your 40s or 50s – when Alzheimer’s really begins – is also key. Mary Sano, PhD, director of the Alzheimer's Disease Research Center at the Icahn School of Medicine at Mount Sinai, cautions that there isn't yet enough research on either diet to fully convince her of specific brain benefits. But you're unlikely to go wrong following a diet of unprocessed foods, she adds. Dr. Sano recommends keeping your weight in check versus attempting to eat for brain health. "There's some evidence that obesity has a whole set of risk factors," she says, "including potentially a cognitive one." - Mary Sano, PhD, Associate Dean, Clinical Research, Professor, Psychiatry, Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai Learn more: https://health.usnews.com/wellness/food/articles/2018-08-28/food-for-thought-diet-may-be-the- top-way-to-influence-how-your-brain-ages
Health24 – August 29 Alzheimer’s Drug Trial Offers New Hope, But Also Uncertainty Researchers report that an experimental drug called BAN2401 slowed mental decline by as much as 30 percent in Alzheimer's patients. It also appeared to clear away the amyloid protein plaques in the brain that have long been linked to the devastating illness. Samuel Gandy, MD, PhD, associate director of the Alzheimer’s Disease Research Center at the Icahn School of Medicine at Mount Sinai, said the 30 percent slowing of the cognitive loss seen in the study might not be enough to make a difference in patients’ everyday function. Would such an effect mean the difference, for example, between allowing a patient to dress or feed themselves without the aid of a caregiver? That's not clear from the study, said Dr Gandy. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care Learn more: https://www.health24.com/Medical/Dementia/Alzheimers/alzheimers-drug-trial-offers-new- hope-but-also-uncertainty-20180829
Scientific American – August 28 United States Is Woefully Unprepared For Nuclear Strike— Sara Reardon The United States is not prepared to deal with the aftermath of a major nuclear attack, despite North Korea’s efforts to develop nuclear weapons and the increasing tensions between nations overall. That was the blunt assessment of public-health experts who participated in a meeting last week on nuclear preparedness, organized by the National Academies of Sciences, Engineering, and Medicine. The US government’s spending on nuclear-weapons research and response has dropped drastically over the past few decades — as has the number of health workers with training in radiation medicine and management. Compounding these concerns, treatments for radiation exposure and burns might not be available in sufficient quantities in the aftermath of a nuclear attack. James Jeng, MD, burn surgeon at the Mount Sinai Health System, said that the detonation of a nuclear bomb can leave behind hundreds of thousands of burn victims. The best treatment for such injuries is skin grafting, he said, but there are only about 300 burn surgeons in the United States who know how to perform the procedure. It might also be difficult to quickly transport enough donor skin to treatment sites, Dr. Jeng added. - James C. Jeng, MD, Burn Surgeon, Mount Sinai Health System Learn more: https://www.scientificamerican.com/article/u-s-is-woefully-unprepared-for-nuclear-strike1/
US News & World Report – August 28 Three Tips For Community College Premed Transfer Students — Yoo Jung Kim More than 40 percent of American undergraduates were enrolled in community colleges in 2010, but in a study published in Academic Medicine, researchers found that only 5 percent of applicants who enrolled in medical school in 2012 had attended community colleges after high school. Despite their ubiquity, community college graduates are vastly underrepresented within the physician workforce. To help community college students on their premedical path, here are three tips for students transferring to a four- year university in hopes of going to medical school. Community college transfer students often find themselves navigating obstacles that their peers figured out years before, such as acclimating to a new academic environment, living far away from home and making new friends. "You have the social stresses of a freshman and the professional pressures of a junior, with medical school applications only a year or two away. With these challenges, the best solution is to find a community that will make you feel OK,” said Andrew Pastor, first year medical student at the Icahn School of Medicine at Mount Sinai. - Andrew Pastor, First Year Medical Student, Icahn School of Medicine at Mount Sinai Learn more: https://www.usnews.com/education/blogs/medical-school-admissions-doctor/articles/2018-08- 28/3-tips-for-premeds-who-transferred-from-community-college
Shape Magazine – August 28 A New Study Claims Even Moderate Amounts Of Alcohol Are Bad For Your Health — Macaela Mackenzie A recent study published in The Lancet, examined drinking on a global level, exploring how boozing around the world contributes to specific diseases – think cancer, heart disease, tuberculosis, diabetes – as well as overall risk of death. The amount of data research looked at was massive – they reviewed over 600 studies on how drinking impacts health. The new study doesn't mean that your happy hour beer is going to kill you, it just means that there might not be a level at which alcohol is protective. Adding to the confusion is that the findings of the new study might be a little misleading. "The new paper looks at studies worldwide, which is not necessarily indicative of the risk in the U.S., as the burden of disease is quite different here than India, for example," explained Julie Devinsky, MS, RD, a nutritionist at The Mount Sinai Hospital. The study also looks at entire populations—not individual habits and health risks, adds White. Together, that means one thing: The results are more of a generalization than a personal health recommendation. - Julie Devinsky, MS, RD, Nutritionist, The Mount Sinai Hospital Learn more: https://www.shape.com/healthy-eating/healthy-drinks/new-study-alcohol-no-health-benefits
Pittsburg-Post Gazette – August 29 Skin Burns And Fire Risks From Electroshock Treatment Device, Report Warns The mental health watchdog group Citizens Commission on Human Rights (CCHR) is warning insurance companies, including Medicaid, to be alert to potential fraudulent claims for the use of electroconvulsive therapy — electroshock treatment (ECT) — for conditions not cleared by the Food and Drug Administration (FDA). Such claims could be putting patients at additional risk from the ECT device that delivers up to 460 volts of electricity to the brain causing a grand mal seizure. The device is currently under scrutiny over the FDA’s failure to meet Congressional mandates to ensure the high-risk Class III ECT devices are proven safe and effective. Charles Kellner, MD, professor of psychiatry at the Icahn School of Medicine at Mount Sinai, estimates that if the FDA limits the use of the ECT device, based on a proposal it made in 2015, it could reduce the 100,000 Americans being electroshocked each year by 40 percent, and insurance companies may exclude “off-label use of ECT, malpractice insurance companies could refuse to cover doctors who provide it, or hospital administrators could prohibit their ECT providers from administering it.” - Charles Kellner, MD, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://markets.post- gazette.com/postgazette/news/read/36858778/skin_burns_and_fire_risks_from_electroshock_treatment_device
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 30, 2018 Date: Friday, August 31, 2018 8:55:43 AM Attachments: ATT00001.txt
In the News August 30, 2018
CBS News – August 30 Parents Urged To Prioritize Their Kids’ Eye Exams The American Optometric Association says 25 percent of children wear or need glasses by the time they enter kindergarten. Doctors now recommend that parents have the eyes of their school-aged children checked every year. Taimesha Frempong, MD, a pediatric ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai said, “Obvious signs that a child may have trouble seeing would be eyes that don’t stay straight, eyes that shake, eyes that wander, poor fixation and poor tracking. Another sign could be as simple as squinting when looking at things far away, this may be indication that they need glasses.” - Taimesha Frempong, MD, Assistant Professor, Ophthalmology, Pediatrics, Medical Education, Icahn School of Medicine at Mount Sinai, Pediatric Ophthalmologist, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.cbsnews.com/video/parents-urged-to-prioritize-their-kids-eye-exams/
JAMA Network News – August 29 A Day In The Life: Caring For Transgender Patients In New York City — Jennifer Abbasi Joshua Safer, MD, has become the first executive director of the Center for Transgender Medicine and Surgery at the Mount Sinai Health System. Along with primary care and psychiatric support, his team offers medical approaches – hormones and a range of surgical options – to align patients’ physical appearance with their gender identity. This practice is known as gender-affirming care. The center also developed the first fellowship in the United States to train physicians in gender-affirming surgery and psychiatric. As an endocrinologist, Dr. Safer spends his clinical hours providing hormone therapy consultations. Early in his career Safer focused on thyroid conditions and says he feels fortunate to have ended up specializing in transgender medicine. He describes it as a happy accident, the result of taking over a departing colleague’s caseload years ago. “It’s certainly very cool to be in on these kinds of experiences with people,” he said. “I’m their doctor for a little period, and yet I’m getting to observe what is one of the greatest, exciting events of their lives.” - Joshua Safer, MD, Executive Director of The Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Endocrinology, Icahn School of Medicine at Mount Sinai Learn more: https://jamanetwork.com/journals/jama/fullarticle/2700375
Genome Web – August 29 Bladder Cancer Response To Immunotherapy Informed by Expression Profiles New research suggests that stromal cells in the tumor microenvironment may interfere with the immune system's efforts to combat bladder cancer in patients treated with anti-PD-1 immunotherapy. Researchers from the Icahn School of Medicine at Mount Sinai, the Mount Sinai spinout Sema4, and elsewhere found that the presence of infiltrating T-cells — the mark of 'hot' tumors — seemed to bode well for tumor response to the PD-1 inhibitor nivolumab, while a related epithelial-mesenchymal transition (EMT) expression signature did not. "Some bladder cancers may not respond to immunotherapy, even though the body has developed an immune response against them, because the T-cells are prevented from reaching the tumor by stromal cells that create an inhospitable 'neighborhood,'" said co-corresponding author Matthew Galsky, MD, director of genitourinary medical oncology at Mount Sinai’s Tisch Cancer Institute. - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Medical Director, Genitourinary Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/sequencing/bladder-cancer-response-immunotherapy- informed-expression-profiles#.W4fwNhsvxQI
Men’s Health – August 29 Eating Chocolate Is Reportedly Good For Your Heart Health — Scott Henderson Chocolate has already been proven to be a strong ally in the quest for health, reducing both wrinkles and stress. However, a new study proposes that in moderation, sugary, store bought, chocolate bars can reduce your risk of heart failure. Based on data collected from more than 500,000 adults, scientists concluded that up to three chocolate bars per month can result in a 23 percent reduced risk of heart disease. “I believe that chocolate is an important dietary source of flavonoids, which are associated with reducing inflammation and increasing good cholesterol,” said lead researcher, Chayakrit Krittanawong, MD, post-graduate of internal medicine at the Icahn School of Medicine at Mount Sinai. Flavonoids promote blood flow and circulation through and increase in nitric oxide levels. As with all news that sounds too good to be true, there is a devastating flip-side to this new research; eating more than three bars a month can actually increase your risk of heart complications by 17 percent. “Chocolate may have high levels of saturated fats,” added Dr. Krittanawong. “I would say moderate dark chocolate consumption is good for health.” - Chayakrit Krittanawong, MD, Post Graduate, Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.menshealth.com.au/eating-chocolate-can-benefit-heart-health Additional coverage: The Daily Telegraph https://www.dailytelegraph.com.au/news/eating-chocolate-in-moderation-can- reduce-heart-failure/news-story/94bc1a65219192164141d057481df67b Body and Soul https://www.bodyandsoul.com.au/health/health-news/three-bars-of-chocolate-a-month- improves-heart-health-study-suggests/news-story/f5fbc2837cf5de5c22f0937184cbf56c The Economic Times https://economictimes.indiatimes.com/magazines/panache/chocolate-lovers-rejoice- 3-bars-can-cut-heart-failure-risk/articleshow/65608376.cms
Orthopedics This Week – August 27 Patient Education Reduces Post-op Opioid Use— Tracey Romero A new study suggests that educating patients before surgery about appropriate post-operative opioid use could help in the battle against opioid addiction. Because many opioid addictions start with an opioid prescription after surgery, there has been a push to find better ways to provide adequate post-op pain control, while at the same time minimizing the number of unused pills after surgery. To see how effective patient education would be to this end, Alexis Colvin, MD, associate professor of sports medicine and orthopedics at the Icahn School of Medicine at Mount Sinai and chief medical officer for the United States Tennis Association, and colleagues investigated opioid use in patients undergoing arthroscopic meniscectomy. On whether doctors should also be limiting how a large a prescription they prescribe, she said, “Absolutely. Patients are less likely to take opioids if they are given a fewer amount. Furthermore, it reduces the number of narcotics that can be diverted to non-therapeutic use.” - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: https://ryortho.com/breaking/patient-education-reduces-postop-opioid-use/
Today Show – August 27 TV Host Talks About His Mission To End HIV Stigma — Megyn Kelly Karl Schmid, host of “On The Red Carpet,” revealed on Facebook in March 2018 that he has been HIV positive for ten years. Schmid said the day he found out he was HIV positive, he thought, “Oh my gosh, I’ve let my parents down.” While initially afraid of publicly sharing his diagnosis, he hopes to end the stigma attached to the disease. Antonio Urbina, MD, associate professor of medicine and infectious disease and medical director of the Institute for Advanced Medicine at the Icahn School of Medicine at Mount Sinai, spoke about that stigma. “A person living with HIV takes their medications, drives their viral load down to undetectable levels,” he said. “Their chances of transmitting is zero.” - Antonio Urbina, MD, Associate Professor, Medicine, Infectious Disease, Medical Director, Institute for Advanced Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.today.com/video/tv-host-karl-schmid-talks-about-his-mission-to-end-hiv- stigma-1307131459732?v=raila
NRDC – August 28 Green Your School— Corey Binns Many school play surfaces are now made of ground-up old tires, known as crumb rubber. Unfortunately, the substance has not been adequately studied for children’s safety. Some districts have taken precautions: In 2009, the Los Angeles Unified School District banned turf fields containing infill from tire- crumb rubber. “Communities throughout the country are saying no to crumb rubber in the face of uncertainty about its health effects and mounting concerns expressed by families and athletes,” said Sarah Evans, PhD, assistant professor of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. Crumb rubber has been banned in Montgomery County, Maryland; Edmonds, Washington; and Hartford, Connecticut, and many school districts have voted against installing crumb rubber fields. “Although turf manufacturers argue that crumb rubber is ‘proven’ safe, local officials, families, and athletic clubs must be made aware of an ongoing federal study that highlights the lack of data to support this claim,” Dr. Evans says. Until scientists confirm results of that study, the Mount Sinai Children’s Environmental Health Center recommends a moratorium on the installation of recycled crumb playing surfaces. - Sarah F. Evans, PhD, Assistant Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.nrdc.org/stories/green-your-school
Science Magazine – August 30 The Alzheimer’s Gamble: NIH Increases Funding to Study Deadly Brain Disease — Jocelyn Kaiser Spurred by projections and a controversial national goal to effectively treat Alzheimer’s disease by 2025, Congress has over three years tripled the National Institutes of Health (NIH) annual budget for Alzheimer's and related dementias, to $1.9 billion. The growth spurt isn't over: Two draft 2019 spending bills for NIH would bring the total to $2.3 billion—more than five percent of their overall budget. The funding blitz targets a problem that looks more intractable than ever. The only approved drugs for Alzheimer's don't stop neurodegeneration, but merely treat symptoms—and not very well. In the past year, several major clinical trials based on the field's leading hypothesis—that reducing the level of β- amyloid plaques that riddle the brains of Alzheimer's patients would halt disease progression—have flopped. Those setbacks have amplified concerns that U.S. officials and some scientists have oversold the plan for a treatment by the middle of the next decade. "I am convinced that we are destined to fail to make the 2025 goal and therefore look like we have failed at our promise,” said Samuel Gandy, MD, PhD, associate director of the Alzheimer’s Disease Research Center at the Icahn School of Medicine at Mount Sinai. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care Learn more: http://www.sciencemag.org/news/2018/08/alzheimer-s-gamble-nih-tries-turn-billions-new- funding-treatment-deadly-brain-disease
ESPN – August 28 You Just Survived A Grueling Match In The Extreme Heat At The US Open. Now What? — Peter Bodo The players who survived the dangerous heat and humidity that plagued the US Open on Tuesday and Wednesday now face a challenge that's less obvious, but no less daunting: recovery. Not just recovering, but recovering sufficiently to find their A-games in the next round. It includes techniques like ice baths and massage. Less obvious: the need to replace carbohydrates. "It's not even the days after, it's hours after,” said Melissa Leber, MD, director of emergency department sports medicine at The Mount Sinai Hospital and US Open consultant and player physician. It's important to have a meal with high fat content and load up with carbs as soon as 30 minutes after a match, she said. Since most players would be hard-pressed to force down food so soon after a stressful match in the heat, liquid meals are the usual solution. These remedial measures all help, as does shrewd tactical play during hot days. - Melissa D. Leber, MD, Assistant Professor, Orthopedics, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Department Sports Medicine, Mount Sinai Hospital, US Open Consultant and Player Physician Learn more: http://www.espn.in/tennis/story/_/id/24516295/2018-us-open-just-survived-grueling-match- heat-us-open-now-what
Forbes – August 30 Eating The Rainbow Can Make You Beautiful, But Is It Doable?— Eustacia Huen There are many different schools of thought when it comes to healthy eating and drinking, though few would criticize the benefits of a balanced diet. Beyond juggling different food groups, many apply similar principles to colors too. One concept is ‘Eating the Rainbow,’ which was introduced to get children to consume more fruits and vegetables. Over the years, more and more adults have joined the movement for better health and skin. Julie Devinsky, MS, RD, a nutritionist at The Mount Sinai Hospital, says, “Each color is created by a set of phytochemicals and antioxidants that have been part of a healthy diet for millions of years. Phytochemicals are natural compounds in plants that contribute to their color, odor and flavor. Antioxidants are touted for their ability to eliminate free radicals.” - Julie Devinsky, MS, RD, Nutritionist, The Mount Sinai Hospital Learn more: https://www.forbes.com/sites/eustaciahuen/2018/08/30/eatrainbow/#1e2dc7964758
Business Insider – August 29 The Best After-Sun Skincare Products You Can Buy— Alyssa Carroll SPF is the foundation of skin health, but despite our best efforts, even the most careful among us have ended up a few stages past sun-kissed after a day at the beach. While broad-spectrum UV protection should be part of everyone's daily skin and body care routine, regular sun exposure strips the skin of essential oils, leading to dryness and flaking. Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital said, "Watermelon is loaded with antioxidants, like vitamin A, vitamin C, and lycopene, and may be useful for preventing free radical damage from UV light and other environmental exposures, as well as brightening and evening complexions and promoting healthy collagen production." - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.businessinsider.com/best-after-sun-skincare-products
Insider – August 29 The Pros And Cons Of Weight Watchers, According To Medical Professionals — Ariana DiValentino Long before the paleo, keto, and South Beach diets, there was Weight Watchers. The program focuses on the healthy things you can eat rather than the unhealthy things you should cut out, and teaches healthy eating skills, like portion control, that remain useful even if you end your membership. Laura Manning, MPH, RD, CDN, clinical nutrition coordinator at Susan and Leonard Feinstein IBD Clinical Center at the Mount Sinai Health System, says she has had great success using Weight Watchers to educate patients about lifelong food habits. Weight Watchers provides a "model for better understanding portion control for weight loss and lifelong weight maintenance." Perri Halperin, MS, RD, dietician at The Mount Sinai Hospital said, "Although the Weight Watchers program has undergone revisions and updates throughout the years to stay current with nutrition trends and research, the basic premise has remained the same: a focus on healthy food choices, portion control, physical activity, nutrition education and community support - all of which promote positive lifestyle change.” - Perri Halperin, MS, RD, Dietician, The Mount Sinai Hospital - Laura Manning, MPH, RD, CDN, Clinical Nutrition Coordinator, Susan and Leonard Feinstein IBD Clinical Center, Mount Sinai Health System Learn more: https://www.thisisinsider.com/weight-watchers-pros-cons-2018-8
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - August 31, 2018 Date: Friday, August 31, 2018 12:38:12 PM Attachments: ATT00001.txt
In the News August 31, 2018
Crain’s Health Pulse – August 31 Mount Sinai's Profits On The Rise — Jonathan LaMantia The Mount Sinai Hospital's operating profit rose 2.5 percent to $105.6 million in the first half of this year, up from $103.1 million in the same period last year. The financial results reflect the performance of the Manhattan hospital and Mount Sinai Queens. "To further expand its footprint and to grow its mix of complex, high-acuity cases, Mount Sinai Hospital will continue to focus on recruiting key physicians in certain identified areas for growth, such as cancer, cardiac, and surgical services," management said in commentary on the financial statements. Another area of focus is reducing length of stay "to create additional capacity, while limiting the cost of investing in new units." - The Mount Sinai Hospital - Mount Sinai Queens Learn more: http://www.crainsnewyork.com/article/20180831/PULSE/180839985/northwell-more-than- doubles-operating-income (Subscription required)
Long Island Herald – August 30 South Nassau Expands Medical Residency Program — Christina Daly South Nassau Communities Hospital received approval for a new Internal Medicine Residency Program from the Accreditation Council for Graduate Medical Education, which will allow for the training of 30 internal medicine physicians. The program was made possible by South Nassau’s affiliation with the Mount Sinai Health System, which provided the graduate medical education slots for use at South Nassau. “Mount Sinai is excited to support a new internal medicine residency program at South Nassau,” said Michael Leitman, MD, dean for graduate medical education and professor of surgery at the Icahn School of Medicine at Mount Sinai. “This will be the first medical school sponsored program of its kind on the South Shore of Long Island. Residents will have exceptional educational, clinical, and research opportunities, and it is our hope that graduates of this program will remain in local practices to care for our community.” - I. Michael Leitman, MD, Dean, Graduate Medical Education, Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.liherald.com/stories/south-nassau-expands-medical-residency-program,106587
Healthcare Dive – August 30 Blockchain In Healthcare: Huge Promise, But Largely Unproven — Meg Bryant Blockchain is abuzz in healthcare today, with providers, payers, and digital health developers all touting its potential to increase work efficiencies, securely transmit and share data, and improve patient outcomes. Numerous examples of late show how companies are looking to capitalize on the trend. Despite all the interest and hype around blockchain, the technology remains largely unproven in healthcare. "It is extremely early in the development cycle of this technology,” said Noah Zimmerman, PhD, director of the Health Data and Design Innovation Center at the Institute for Next Generation Healthcare at the Icahn School of Medicine at Mount Sinai, and it’s newly launched Center for Biomedical Blockchain Research. "We’re really building the infrastructure and plumbing right now in the same way that the protocols for the internet lay the groundwork for what would later become possible." The Center for Blockchain Biomedical Research hopes to answer some of the questions about what blockchain can and can't solve in healthcare. It is focusing on three types of projects: academic research; developing and testing its own blockchain systems within the Mount Sinai Health System; and partnering with tech companies and healthcare organizations in applying blockchain technology. - Noah H. Zimmerman, PhD, Assistant Professor, Genetics and Genomic Sciences, Director, Health Data and Design Innovation Center, Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthcaredive.com/news/blockchain-in-healthcare-huge-promise-but-largely- unproven/529666/
HIV Plus Magazine – August 30 Mouse Study: Memory Problems Observed In About Half With HIV— Benjamin M. Adams A new study on HIV-positive mice proves the virus causes cognitive difficulties, which can be prevented, but not reversed, by antiretroviral treatment. About half of people living with HIV now suffer from memory dysfunction, but according to research, early intervention with antiretroviral treatment could prevent such neurological impacts. The study, published in the journal PLOS Pathogens, was led by David J. Volsky, PhD, professor of medicine, pathology and infectious diseases at the Icahn School of Medicine at Mount Sinai, and Mary Jane Potash, PhD, associate professor of medicine, infectious diseases and pathology at the Icahn School of Medicine at Mount Sinai. It’s the first time scientists were able to reproduce in mice the viral reservoirs and cognitive declines seen in people living with HIV. Investigators traced cognitive problems to active HIV in large white blood cells, which could be the reasons it begins in the first place. Mount Sinai researchers developed EcoHIV, a genetically engineered rodent version of HIV that reproduces many aspects of human contraction, so that scientists could study HIV in an animal model that closely replicates what people experience. - David J. Volsky, PhD, Professor, Medicine, Pathology, Infectious Diseases, Icahn School of Medicine at Mount Sinai - Mary Jane Potash, PhD, Associate Professor, Medicine, Infectious Diseases, Pathology, Icahn School of Medicine at Mount Sinai Learn more: https://www.hivplusmag.com/treatment/2018/8/30/memory-problems-observed-about-half- those-hiv eCancer News – August 30 Discovery Could Lead To Higher Immunotherapy Response Rates For Bladder Cancer Patients Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors. The researchers showed that expression of a set of genes that are typically linked to more aggressive cancers was actually more commonly linked to stromal cells rather than bladder cancer cells themselves. "Some bladder cancers may not respond to immunotherapy, even though the body has developed an immune response against them, because the T-cells are prevented from reaching the tumour by stromal cells that create an inhospitable 'neighborhood,'" said Matthew Galsky, MD, director of genitourinary medical oncology at Mount Sinai’s Tisch Cancer Institute. Dr. Galsky and his colleagues are now trying to validate the gene expression identified in their study as a biomarker that could help refine clinical trials and treatment in the future by predicting the level of response or resistance to PD-1/PD-L1 inhibitors. - Matthew Galsky, MD, Professor, Medicine, Hematology and Medical Oncology, Urology, Medical Director, Genitourinary Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://ecancer.org/news/14683-discovery-could-lead-to-higher-immunotherapy-response- rates-for-bladder-cancer-patients.php
Medical Xpress – August 30 Radn Tx Alone May Be Adequate For Stage I Anal Cancer In Elderly For older patients with stage I squamous cell carcinoma of the anus, radiation alone is associated with outcomes that do not differ significantly from those of chemoradiation, according to research published in Diseases of the Colon & Rectum. Michael Buckstein, MD, PhD, assistant professor of radiation oncology at the Icahn School of Medicine at Mount Sinai, and colleagues conducted a cohort analysis to examine whether outcomes are improved with the addition of chemotherapy to radiation along for stage I squamous cell carcinoma of the anus. Researchers found that, compared to patients treated with lone radiotherapy, patients receiving chemoradiation had improved unadjusted overall survival. However, after propensity-score method adjustment, there was no significant between-group difference in overall survival, cause-specific survival, colostomy-free survival, or disease-free survival. "Lone radiation may be associated with adequate oncologic outcomes when used to treat older and sicker patients with stage I anal cancer," the authors said. - Michael Buckstein, MD, PhD, Assistant Professor, Radiation Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-08-radn-tx-adequate-stage-anal.html Additional coverage: Drugs.com https://www.drugs.com/news/radn-tx-alone-may-adequate-stage-anal-cancer-elderly- 76726.html Doctors Lounge https://www.doctorslounge.com/index.php/news/pb/82902
Medscape – August 31 Drug-Coated Balloon In Line With DES In Small De Novo Lesions — Patrice Wendling In patients with small de novo coronary lesions, drug-coated balloon (DCB) angioplasty was comparable with the preferred treatment strategy of second-generation drug-eluting stents (DES), in the noninferiority BASKET-SMALL 2 trial. Following the formal presentation of the results, Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, and director of the Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, said DCB “is safe and comparable to DES in terms of MACE and offers an important alternative in patients with small-vessel disease. This important potential benefit of not having a permanent implant in our patients with diffuse long lesions is tremendous." Dr. Mehran concluded that longer-term data is necessary and that the trial “sets the stage for a larger study in truly small-vessel disease of less than 2.5 millimeters in diameter.” - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/901444
Metro NY – August 30 Back To School: Why Kids Need To Play More Than One Sport — Sheila Dougherty School is back in session for most kids, and with the start of the academic year comes decisions about extracurricular activities. While sports are healthy and character-building, focusing on a single sport might not be the way to go for every kid. Alexis Colvin, MD, associate professor of sports medicine and orthopedics at the Icahn School of Medicine at Mount Sinai, and chief medical officer of the US Open, explains the importance of variety. “Allowing children to play more than one sport can help in preventing overuse injuries. Mixing higher and lower-impact sports is a good rule of thumb. This doesn’t mean that your child should play two-three travel sports per week — informal activity has value as well,” she said. - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, US Open Learn more: https://www.metro.us/body-and-mind/health/back-to-school-why-kids-need-to-play-more- than-one-sport
Women’s Health – August 30 Ten Times Your Weight Gain Might Signal A Big Health Problem — Kristen Dodd, Ashley Mateo, and Carly Breit Sudden weight gain with no discernible cause may be a sign something is askew in your body. Your hormones could be out of whack, or other sneaky health conditions could be causing your metabolism to misfire. Cushing’s disease causes excess cortisol production and can trigger weight gain in the abdominal area and the back of the neck, said Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease and the director of weight and metabolism management program at the Icahn School of Medicine at Mount Sinai. “Cushing’s typically presents with significantly low energy and complications like diabetes, high blood pressure, and high cholesterol. But the telltale sign is very large, red stretch marks on their belly,” she said. If this sounds eerily familiar, talk to your doctor as soon as possible. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/health/a19992956/unexplained-weight-gain/
Reader’s Digest – August 31 Ten Diseases That Could Be Cured In Your Lifetime — Denise Mann, MS Each year, there are thousands of fun runs, drivers, and fundraisers focused on curing diseases. It’s working: we may see cures for these diseases in our lifetimes. As many as 5.7 million Americans are living with Alzheimer’s, and by 2050, this number will increase to close to 14 million, according to the Alzheimer’s Association. Incredibly, a cure for this degenerative memory-robbing brain disease may be within our grasp. Researchers are excited by new treatments, including those that help reduce the buildups of the plaque in the brain that can lead to dementia in people with Alzheimer’s, such as gene therapy, shared Amy Aloysi, MD, MPH, assistant professor of psychiatry and neurology at the Icahn School of Medicine at Mount Sinai. - Amy Aloysi, MD, MPH, Assistant Professor, Psychiatry, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/diseases-could-be-cured-in-your-lifetime/
AOL News – August 31 Silent Signs Of A Heart Attack During a heart attack, blood flow to the heart is reduced, putting extra stress on the muscle, which could make you feel exhausted. Don’t be afraid to ask your doctor to do an electrocardiogram (EKG), which checks heart activity. “Sometimes when people present with lethargy, doctors won’t immediately order an EKG, which can detect a heart attack; but you should request one from your doctor, just to be safe,” said Annapoorna Kini, MD, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, and director of the Cardiac Catheterization Laboratory at the Mount Sinai Hospital. - Annapoorna S. Kini, MD, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Interventional Director, Structural Heart Program, Director, The Cardiac Catheterization Laboratory, Mount Sinai Hospital Learn more: https://www.aol.com/article/lifestyle/2018/08/30/doctor-uses-cpr-to-save-mans-life-during- their-first-date/23512800/##slide=7368594#fullscreen
Prevention Magazine – August 30 How To Get Rid Of Those Stubborn Blackheads On Your Nose— Alisa Hrustic A blackhead is a combination of oil and dead skin cells sitting in a dilated pore, resulting in a tiny bump, said Melissa K. Levin, MD, clinical instructor of dermatology at the Icahn School of Medicine at Mount Sinai. Your nose is a magnet for blackheads because there is simply a higher concentration of pores in that area for most people. “Having blackheads doesn’t mean your skin is dirty and needs to be scrubbed away aggressively,” said Dr. Levin. Treat it nicely, and you’ll clear the problem. When you’re looking for blackhead-banishing products, a retinoid is a good place to start. “Retinoids are the backbone of acne treatment for all types of acne because they improve skin cell turnover to prevent dead skin cells from clogging pores,” explains Dr. Levin, adding that they’re also a potent anti-inflammatory. - Melissa K. Levin, MD, Clinical Instructor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/beauty/a20481172/how-to-get-rid-of-blackheads-from-nose/
Prevention Magazine – August 31 Hyaluronic Acid Is The Ingredient You Need For Firmer, Younger-Looking Skin When it comes to skincare, the word “acid” might conjure thoughts of exfoliation or even irritation—but hydration? Not so much. Yet a certain type of acid can be seriously hydrating. Hyaluronic acid, a tried- and-true ingredient that’s experiencing a renaissance right now, can satisfy even the thirstiest complexions. Applied topically, this humectant acts like a tiny sponge, holding up to a thousand times its weight in water and pulling it to the skin’s surface to quench and plump, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. “It is commonly used as an ingredient in moisturizers because of its hydration benefits, and can even help plump the skin to improve the appearance of fine lines.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.prevention.com/beauty/skin-care/g22876558/best-hyaluronic-acid-serum- cream/
If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200