PERIODICUM BIOLOGORUM UDC 57:61 VOL. 113, No 1, 43–49, 2011 CODEN PDBIAD ISSN 0031-5362 Review Biology of the Corpus luteum Abstract JELENA TOMAC \UR\ICA CEKINOVI] Corpus luteum (CL) is a small, transient endocrine gland formed fol- JURICA ARAPOVI] lowing ovulation from the secretory cells of the ovarian follicles. The main function of CL is the production of progesterone, a hormone which regu- Department of Histology and Embryology lates various reproductive functions. Progesterone plays a key role in the reg- Medical Faculty, University of Rijeka B. Branchetta 20, Rijeka, Croatia ulation of the length of estrous cycle and in the implantation of the blastocysts. Preovulatory surge of luteinizing hormone (LH) is crucial for Correspondence: the luteinization of follicular cells and CL maintenance, but there are also Jelena Tomac other factors which support the CL development and its functioning. In the Department of Histology and Embryology Medical Faculty, University of Rijeka absence of pregnancy, CL will cease to produce progesterone and induce it- B. Branchetta 20, Rijeka, Croatia self degradation known as luteolysis. This review is designed to provide a E-mail:
[email protected] short overview of the events during the life span of corpus luteum (CL) and to make an insight in the synthesis and secretion of its main product – pro- Key words: Ovary, Corpus Luteum, gesterone. The major biologic mechanisms involved in CL development, Progesterone, Luteinization, Luteolysis function, and regression will also be discussed. INTRODUCTION orpus luteum (CL) is a transient endocrine gland, established by Cresidual follicular wall cells (granulosa and theca cells) following ovulation.