bioRxiv preprint doi: https://doi.org/10.1101/412718; this version posted September 12, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Estimating the burden of α-thalassaemia in Thailand using a 2 comprehensive prevalence database for Southeast Asia 3 Carinna Hockham1,2*, Supachai Ekwattanakit3, Samir Bhatt4, Bridget S Penman5, 4 Sunetra Gupta2, Vip Viprakasit3,6 & Frédéric B Piel7 5 6 1The George Institute for Global Health, Sydney, Australia; 2 Evolutionary Ecology of 7 Infectious Disease Group, Department of Zoology, University of Oxford, Oxford, UK, 8 3Thalassaemia Centre, Faculty of Medicine, Siriraj Hospital, Mahidol University, 9 Bangkok, Thailand; 4Department of Infectious Disease Epidemiology, School of Public 10 Health, Imperial College, London, UK; 5Warwick Infectious Disease Epidemiology 11 Research, School of Life Sciences, Warwick University, Coventry, UK; 6Department of 12 Paediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 13 Thailand; 7MRC-PHE Centre for Environment & Health, Department of Epidemiology 14 & Biostatistics, School of Public Health, Imperial College London, London, UK 15 16 *For correspondence:
[email protected] 17 18 bioRxiv preprint doi: https://doi.org/10.1101/412718; this version posted September 12, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 19 Abstract 20 Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops 21 fetalis, are an important public health concern in Southeast Asia.