Genetics & Molecular Biology Thieme Two Genetic Variants Associated with Plantar Fascial Disorders Authors Stuart K. Kim1, John P.A. Ioannidis2, Marwa A. Ahmed3, Andrew L. Avins4, John P. Kleimeyer5, Michael Fredericson5, Jason L. Dragoo5 Affiliations Stanford, California 94305 1 Dept. Developmental Biology, Stanford University United States Medical Center, Stanford CA, USA Tel.: + 1/650/867 3189, Fax: + 1/650/725 7739 2 Dept. of Medicine, Stanford Prevention Research Center
[email protected] and Dept. of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, ABSTRACT and Dept. of Statistics, Stanford University School of Plantar fascial disorder is comprised of plantar fasciitis and Humanities and Sciences, Stanford CA, USA plantar fibromatosis. Plantar fasciitis is the most common 3 Dept. Physical Medicine and Rehabilitation, Harvard cause of heel pain, especially for athletes involved in running Medical School, Boston MA, USA and jumping sports. Plantar fibromatosis is a rare fibrous -hy 4 Kaiser Permanente Northern California, Division of perproliferation of the deep connective tissue of the foot. To Research, Oakland, California, USA identify genetic loci associated with plantar fascial disorders, 5 Dept. Orthopaedic Surgery, Stanford University Medical a genome-wide association screen was performed using publi- Center, Stanford CA, USA cally available data from the Research Program in Genes, Envi- ronment and Health including 21,624 cases of plantar fascial Key words disorders and 80,879 controls. One indel (chr5:118704153:D) Genome-wide association study, plantar fasciitus, sports and one SNP (rs62051384) showed an association with plantar injury, plantar fibromatosis fascial disorders at genome-wide significance (p < 5 × 10 − 8) with small effects (odds ratios = 0.93 and 1.07 per allele, re- Bibliography spectively).