US 20100183528A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0183528A1 Maloney et al. (43) Pub. Date: Jul. 22, 2010

(54) ACNETREATMENT POWDER FOUNDATION Publication Classification (75)75) invenorInventors: Johnobtainstity. D. Malonev, Salisburv. NC (51) A61KInt. Cl. 8/368 (2006.01) Davidson NC (US) s A61O 1704 (2006.01) s A61O I/00 (2006.01) Correspondence Address: A6IP 7/10 (2006.01) INTELLECTUAL PROPERTY f TECHNOLOGY LAW (52) U.S. Cl...... 424/60 PO BOX 14329 RESEARCH TRIANGLE PARK, NC 27709 (US) (57) ABSTRACT (73) Assignee: HARMONY LABORATORIES, Dry powder foundation formulations that include a sustained INC., Kannapolis, NC (US) release salicylic acid composition, an effective, buffering amount of one or more Salicylate ions, and one or more of Zinc (21) Appl. No.: 12/639,851 and titanium oxides, and pigments or colorants, are disclosed. 1-1. The formulations provide both acne treatment and preven (22) Filed: Dec. 16, 2009 tion, and Sunblock protection. The formulation can also O O include other Sunblocking or Sunscreen agents to prevent Related U.S. Application Data photoaging and Sunburn, such as avobenzone, and 3-ben (60) Provisional application No. 61/138.436, filed on Dec. Zophenone, and other cosmetically-acceptable active agents 17, 2008. and excipients. US 2010/0183528 A1 Jul. 22, 2010

ACNE TREATMENT POWDER FOUNDATION used as a foundation that provides both acne treatment and prevention and Sunblock protection. CROSS-REFERENCE TO RELATED 0007 Because the composition provides salicylic acid in APPLICATION the form of a Sustained-release composition, the salicylic acid remains effective for an extended period of time. Poly Pore 0001. This is a U.S. non-provisional of U.S. Provisional 450SA, a polymeric formulation including salicylic acid in an Patent Application No. 61/138.436 filed on Dec. 17, 2008. allyl methacrylate crosspolymer, is a representative poly The disclosure of the foregoing application is hereby incor meric Sustained-release form of Salicylic acid, though other porated herein by reference in its respective entirety, for all Sustained-release formulations can also be used. Further, as purposes, and the priority of Such application is hereby anti-acne additives, the formulation includes one or more claimed under the provisions of 35 USC 119. salicylates, ideally isolated as an extract from willow bark and/or aspen bark. In addition to the salicylic acid and one or BACKGROUND OF THE INVENTION more salicylates, the formulation can also include other anti 0002 Acne is the most common skin disorder in the US, acne agents, including Sulfur, benzoyl peroxide, and resorci and although this condition is generally associated with nol. puberty, it is not confined to adolescence and can persist well 0008. In addition to normal excipients found in dry pow into adulthood. The acne condition is a complex one, der foundations, the formulation includes Zinc oxide and/or impacted by a number of intrinsic and extrinsic factors, and, titanium dioxide as Sunblocking agents. The formulation can as such, must be treated with a multifaceted approach. Treat also include other Sunblocking or Sunscreen agents to prevent ment should address overproduction of sebum, hyperkerati photoaging and Sunburn, such as avobenzone, and 3-ben nization, overgrowth of P. acnes, and the ultimate blockage Zophenone. and irritation of the pilosebaceous follicle. Extrinsic factors, 0009. The foundation formulation typically also includes which exacerbate the acne condition, involve exfoliation via colorants/pigments, for example, inorganic colorants/pig harsh abrasives or mechanical Scrubbing, UV exposure, and ments, one example of which is a blend of iron oxide, bismuth Some topical and oral Substances. oxychloride, and mica. 0003 Salicylic acid is a relatively mild beta-hydroxy acid, 0010. In one embodiment, the composition further which is proven effective at correcting abnormal desquama includes one or more additional components, such as Zinc tion, the natural shedding of the outermost stratum corneum gluconate, Active Powder Purity LS9695, and pearl powder, cells. Its treatment benefits extend beyond that of the acne such as PPP-100 pearl powder. condition to include psoriasis, keratoses, and ichthyoses. By 0011. In one aspect of this embodiment, the formulation penetrating into the follicle, Salicylic acid encourages the has the following ingredients, in the ranges of weight percent sloughing of dead skin cells and other cellular debris and, ages provided below in Table 1. ultimately, clears blockages. Further benefits of its exfoliat ing action are improvements in skin texture and hyperpig TABLE 1 mentation. Representative Formulation Ranges 0004 While there are a wide variety of products on the market containing salicylic acid for treating the acne condi Ingredient Range % wiw tion, most are in the forms of lotions, creams, and liquids, Iron Oxide, Bismuth Oxychloride & Mica blend 40-75 including liquid foundation makeup. Incorporation of Sali Titanium Dioxide 5-40 cylic acid into color foundations is advantageous, as it helps Zinc Oxide 5-35 Poly-Pore 450SA O.10-12.OO to clear current breakouts while concealing them. Further Salicylic Acid & Allyl Methacrylates Crosspolymer more, continued use will help to prevent future breakouts. ABS White Willow Bark Extract Powder O.10-1O.OO Loose powder foundations are currently enjoying much Salix Nigra (Willow) Bark Extract popularity, as they impart a lightweight, natural feel on the Phytocide Aspen Bark Extract Powder O.10-1O.OO skin while providing great coverage, long wearability, oil Populus Tremuloides (Aspen) Bark Extract Givobio GZn O.10-1O.OO absorption, and diffuse the appearance of blemishes and other Zinc Gluconate skin imperfections. Providing a loose powder foundation Active Powder Purity LS9695 O.10-1O.OO with acne treatment benefits would represent an improvement Exfoliance Bamboo O.10-1O.OO over an already popular product type. Bambusa Arundinacea Stem Powder PPP-100 Pearl Powder O.10-1O.OO 0005. However, the presence of free salicylic acid may Pearl Powder serve to irritate the skin. Accordingly, it would be advanta geous to provide a loose powder foundation that provides the benefits of salicylic acid, while minimizing the degree of skin 0012. The foundation formulations combine the benefits irritation. The present invention provides such a foundation. of acne treatment and UV protection with lightweight cover age. The foundation formulations combat acne by reducing & SUMMARY OF THE INVENTION regulating sebum production, providing gentle exfoliation, destroying P acnes and other harmful microbes, soothing 0006. The present invention relates to a cosmetic compo irritation and inflammation, and restoring barrier function. sition, in the form of a dry powder foundation, that includes a The incorporation of Sunscreens also helps to improve acne, Sustained-release salicylic acid composition, an effective, as UV exposure is known to exacerbate the condition. buffering amount of one or more salicylate ions, and one or 0013. In some embodiments, the formulation can have a more of Zinc and titanium oxides. The composition can also sun protection factor (SPF) of 15 or more. The formulation include other cosmetically-acceptable actives and excipients can help heal blemishes and prevent future breakouts, clear found in dry powder foundations. The composition can be blockages, and help improve skin texture and hyperpigmen US 2010/0183528 A1 Jul. 22, 2010 tation remaining after breakouts. The Salicylic acid/salicylate well as non-active agents (excipients) can be present. The combination reduces and absorbs surface sebum, provides various active agents and optional components are described gentle exfoliation and stimulates natural exfoliation, and pro in more detail below. vides anti-microbial activity. The formulation can provide 0022 Acne Treatment antioxidant activity, soothe skin and mitigate irritation, pro 0023 The anti-acne additives include a combination of a vides a modern, natural look, provide excellent coverage and Sustained-release salicyclic acid composition, and salicy wearability, and diffuse the look of blemishes and uneven lates, either in the form of a natural extract or as a pure pigmentation compound. Examples of extracts that include Salicylates 0014. The present invention will be better understood with include willow bark and aspen bark. The amount of the sus reference to the following detailed description. tained-release salicylic acid composition, by weight percent, typically ranges from between about 0.10 to about 12.00, DETAILED DESCRIPTION which provides between about 0.05 to about 6.00 free sali cylic acid. The amount of the Salicylates, by weight percent, 0015. A dry powder foundation formulation is disclosed. typically ranges from between about 0.10 to about 10.00, The dry powder foundation formulation includes conven which can be present in the form of an extract of a natural tional foundation ingredients, as well as Sunblocking agents product that includes salicylates, such as willow bark and and anti-acne additives. The formulation provides controlled aspen bark. When in the form of an extract, the extract itself release of salicylic acid, and includes extracts containing one is typically present in a range of between about 0.055 to about or more salicylate salts. 5.50 free salicylic acid. 0024 Salicylic acid is a mild keratolytic agent, which DEFINITIONS promotes descuamation. The acne treatment powder founda tion formulation described herein uses an extended-release 0016. The following definitions will be useful in under salicylic acid delivery system. Representative extended-re standing the invention described herein. lease/sustained-release delivery systems include, but are not 0017. In this disclosure, the term "salicylate ion' includes limited to, Poly Pore 450 SA, MultiSalTM Salicylic Acid 10, naturally-occurring and man-made Salicylate ions, and spe MultiSalTM SAL 20, MultiSalTM Salicylic Acid 30, Biogenic cifically includes extracts of willow bark and aspen bark, Salicylic Acid, and Lipo CD-SA. This slow, sustained release which include natural salicylates. The term “effective, buff of the active allows for long-lasting availability and helps to ering amount” refers to an amount of salicylate ion capable of minimize irritation. neutralizing, at least in part, the acidic nature of the salicylic (0025 Poly Pore 450 SA is a polymeric formulation acid. For example, the presence of 10 percent or more of the including salicylic acid in an allyl methacrylate crosspoly molar amount of salicylates, relative to Salicylic acid, can be mer. MultiSalTM consists of solid hydrophobic nanospheres effective. encapsulated in a water or pH sensitive microsphere. Bio 0018. The terms "cosmetic' or "cosmetic products” or genic Salicylic Acid is a proprietary material which encapsu "cosmetic compositions as used herein, mean (i) articles lates Salicylic acid, and has a roughly 25% concentration of intended to be rubbed into, applied with a brush, or otherwise salicylic acid. Lipo CD-SA is a proprietary material compris applied to the face of a human for cleaning, beautifying, ing 5% Salicylic acid in encapsulated powder form. promoting attractiveness, or altering the appearance, and (ii) 0026. To supplement the action of salicylic acid, natural articles intended for use as a component of any such articles, salicylates, White Willow Bark and Aspen Bark Extracts, are e.g., Sun screening compositions, medicinal compositions, added to enhance the anti-acne activity by providing addi and the like. tional exfoliation and antimicrobial action. White Willow Bark has been shown to accelerate cell renewal more effec I. Formulation Components tively compared to free salicylic acid, while Aspen Bark works as an ideal preservative, inhibiting growth of molds, 0019. The foundation includes conventional dry powder yeast, and a wide array of bacteria. formulation components, anti-acne agents, and Sunblocking 0027 Salicylic acid is a keratolytic agent; promotes agents, and can also include a variety of other agents designed descuamation, clears blockages, helps prevent new lesions, & to provide beneficial treatments to the skin of the user. improves skin texture and hyperpigmentation after breakouts. 0020. The acne treatment powder foundation is a multi The sustained release form of salicylic acid helps to minimize purpose product, combining the benefits of acne treatment irritation and provide long-lasting availability of the active and UV protection with lightweight yet Superior coverage ingredient. Irritation is mitigated by minimizing the concen compared to traditional loose powder foundations. The foun tration of Salicylic acid contacting the skin at any given dation combats acne by reducing & regulating sebum produc moment. The presence of Salicylates also helps reduce the tion, providing gentle exfoliation, destroying P acnes and acidity of the salicylic acid, by providing a buffer. That is, other harmful microbes, soothing irritation and inflamma when an acid (in this case, Salicylic acid) and its conjugate tion, and restoring barrier function. Incorporation of Sun base (in this case, salicylates) are present in a formulation, screens also helps improve acne, as UV exposure is known to each buffers the other, according to the well-known Hender exacerbate the condition. son-Hasselbach equation (pH pKa+log (concentration of 0021. Like conventional dry powder foundations, the acid/concentration of base). foundation formulation described herein also includes colo 0028. Any cosmetically-acceptable salt of salicylic acid rants/pigments. In one embodiment, the composition further (i.e., Salicylate) can be used in the formulations described includes one or more additional components, such as Zinc herein. Representative salts include, but are not limited to, gluconate, Active Powder Purity LS9695, and pearl powder, salts with cations of ammonium, Sodium, potassium, magne such as PPP-100 pearl powder. Additional active agents, as sium, calcium, strontium, barium, aluminum, iron, Zinc, bis US 2010/0183528 A1 Jul. 22, 2010

muth and organic amines. A salt with at least one of these Zothiophene derivatives: phloretin: PHLOROGINE (avail cations is preferable. More preferable is a sodium, potassium, able from Secna); phosphatidyl choline; proteolytic magnesium or Zinc salt, still more preferable is a Sodium, enzymes; quercetin: red sandalwood extract; resorcinol; rose potassium or Zinc salt, and particularly preferable is a sodium mary extract; rutin; Sage extract; salicin; salicylic acid; skull salt. cap extract, Siber hegner extract: Siberian saxifrage extract; 0029. The salicylic acid and salicylates can be used in silicol; sodium lauryl Sulfate; sodium sulfoacetamide; concentrations from about 0.05% to about 12.0% by weight, Sophora Extract (available from Maruzen); sorbic acid; sul where the amount of free salicylic acid ranges from about fur; Sunder vati extract; tea tree oil; tetracyline; tetrahydroa 0.10 to about 6.0 by weight. bietic acid; thyme extract; tioxolone; tocopherol; trehalose 0030. Other representative anti-acne agents that can be 6-undecylenoate; 3 tridecene-2-ol; triclosan; tropolone; UNI used, in addition to the salicylic acid and Salicylates, include TRIENOLT27 (available from Unichem, located in Gouda, Sulfur, benzoyl peroxide, resorcinol, and resorcinol monoac Netherlands); vitamin D and its analogs; white thyme oil; etate. When present, Sulfur is typically in an amount of willow bark extract; Wogonin; YlangYlang; Zinc glycerolate; between 0.1 and 10.0% w/w; benzoyl peroxide is typically in Zinc linoleate; Zinc oxide; Zinc pyrithione; Zinc sulfate and an amount of between 0.5 and 5.0% w/w, resorcinol is typi mixtures thereof. cally in an amount of between 0.1 and 2.0% w/w, and resor 0033 UV Protection cinol monoacetate is typically in an amount of between 0.1 0034 Sunscreen and/or Sunblocking agents are present in and 3.0% w/w. the dry powder foundation described herein. The term "sun 0031 Additional Optional Anti-Acne Agents screen agent’ as used herein defines ultraviolet ray-blocking 0032. In addition to the salicylic acid, salicylates, and the compounds exhibiting absorption within the wavelength otheranti-acne agents listed above, otheranti-acne agents can region between about 290 and about 400 nm. be included in the dry powder foundation described herein. 0035. The formulation includes, as sunblocking agents, Non-limiting examples of useful anti-acne actives include the one or more of Zinc oxide and titanium dioxide, and, most keratolytics Such as Salicylic acid (o-hydroxybenzoic acid), preferably, a combination of these two agents. The range of derivatives of Salicylic acid Such as 5-octanoyl salicylic acid these ingredients in the formulations is typically between and 4 methoxysalicylic acid; retinoids such as retinoic acid about 8.10 and about 35.00 weight percent for titanium diox and its derivatives (e.g., cis and trans); Sulfur-containing D ide, and between about 10 and about 25.65 weight percent for and Lamino acids and their derivatives and salts, particularly Zinc oxide. their N-acetyl derivatives, a preferred example of which is 0036 Zinc oxide and titanium dioxide are mineral pig N-acetyl-L-cysteine; lipoic acid; sebostats such as flavonoids ments often used for photoprotection, as they are opaque to and bioflavonoids; bile salts such as Scymnol Sulfate and its both UVA and UVB radiation. Although both provide opacity derivatives, deoxycholate, and cholate; abietic acid; ada to UV light, titanium dioxide provides 3 to 4 times better palene; allantoin, aloe extracts; arbietic acid and its salts; coverage and photoprotection. Titanium dioxide is a physical aryl-2,4 dioxo oxazolidine derivatives; ASEBIOL (available Sunscreen providing covering power and UV protection. Zinc from Laboratories Serobiologiques, located in Somerville, oxide is a physical Sunscreen that provides covering power N.J.); azaleic acid; barberry extracts; bearberry extracts; and UV protection; reduces sebum production, may promote belamcanda chinensis; benzoquinolinones; benzoyl peroX wound healing, and has powerful antioxidant activity. Zinc ide; berberine: BIODERMINE (available from Sederma, oxide also provides additional benefits beyond UV protec located in Brooklyn, N.Y.); bioflavinoids; bisabolol; S-car tion. Zinc is a component of at least 70 metalloenzymes and boxymethyl cysteine; carrot extracts; cassin oil; clove is also needed in protein, DNA, and RNA synthesis. In addi extracts; citral; citronellal; climazole; Completech MBAC tion, it is a cofactor for Superoxide Dismutase (SOD), an OS (available from Lipo); CREMOGEN M82 (available enzyme providing crucial antioxidant activity and alleviating from Dragoco, located in Totowa, N.J.), cucumber extracts; oxidative stress in cells. Zinc oxide is classified as a Category dehydroacetic acid and its salts; dehydroeplandersterone sali 1 skin protectant, provides antimicrobial activity, and is cylate; dichlorophenyl imidazoldioxolan which is commer thought to be implicated in reducing sebum production and cially available as COMPLETECH MBAC-OS (from Lipo, promoting wound healing. located in Paterson, N.J.); DL valine and its esters; DMDM 0037 Utilizing a combination of these two compounds hydantoin: Epicutin TT (available from CLR); erythromycin; will provide ample UV protection, while also supplementing escinol; ethylhexyl monoglyceryl ether; ethyl 2-hydroxy acne treatment and improving skin condition. undecanoate; farnesol; farnesol acetate; geranoil; glabridin; 0038. Ideally, the particle sizes of these agents are in the gluconic acid; gluconolactone; glyceryl monocaprate; gly micron size or less. Microparticulate (also known as colic acid; grapefruit seed extract; gugu lipid; Hederagenin microfine) Zinc oxide and titanium dioxide are particulate (available from Maruzen); hesperitin; hinokitol; hops extract; Sunscreen ingredients that absorb broad-spectrum ultraviolet hydrogenated rosin; 10 hydroxy decanoic acid; ichtyhol; (UV) irradiation. interleukin 1 alpha antagonists; iodo-2-propynyl butyl car 0039. Additional Optional Sunscreen Actives/UV bamate; Kapilarine (available from Greentech); ketocona Absorbers Zole; lactic acid; lemon grass oil; Lichochalcone LR15 (avail 0040. In addition to titanium dioxide and/or zinc oxide, able from Maruzen); linoleic acid: LIPACIDE C8CO other organic Sunscreens can also be used. Also, UV absorb (available from Seppic, located in Paris, France); lovastatin: 4 ers, such as 3-benzophenone and avobenzone can be present methoxysalicylic acid; metronidazole; minocycline: muku in the formulation. When present, 3-benzophenone is typi rossi; neem seed oil; vitamin B compounds (such as niaci cally present in a concentration of between about 0.1 and namide and nicotinic acid); nisin; 5-octanoly Salicylic acid; about 10 weight percent, and avobenzone is typically present octopiroX; panthenol; 1-pentadecanol; peonia extract; pep in a concentration of between about 0.1 and about 5 weight permint extract; phelladendron extract; 2-phenyl-ben percent. US 2010/0183528 A1 Jul. 22, 2010

0041. Other representative sunscreens and sunblocking 0046. The exact amounts of sunscreens which can be used agents include iron oxide and polymer particles such as those will vary depending upon the Sunscreen chosen and the of polyethylene, polymethylmethacrylates and polyamides A desired Sun Protection Factor (SPF) to be achieved. SPF is a wide variety of conventional Sunscreening agents are Suitable commonly used measure of photoprotection of a Sunscreen for use in the present invention as described in Segarinet al., against erythema. See Federal Register, Vol.43, No. 166, pp. at Chapter VIII, Pages 189 et seq., "Cosmetics Science and 38206-38269, Aug. 25, 1978, which is incorporated herein by Technology', the disclosure of which is incorporated herein reference in its entirety. by reference. 0047 SPF of the Resulting Formulations 0042 Sunscreens are typically classified into five groups 0048. It is believed that the formulations can provide an based upon their chemical structure: para-amino benzoates; SPF of around 15, particularly when rubbed into the skin salicylates; cinnamates; benzophenones; and miscellaneous rather than simply being dusted onto the skin. The SPF can be chemicals including menthyl anthranilate and digalloyl tri measured, for example, using a Labsphere UV-1000S UV oleate. Salicylates are present in the composition as anti-acne transmittance analyzer, which is commonly used to obtain in agents, and thus serve a dual role as a Sunscreen. vitro SPF data on cosmetic products. 0043 Specific suitable sunscreening agents include, for 0049 Optional Additional Components example: p-aminobenzoic acid, its salts and derivatives, 0050. The dry powder foundation formulations described anthranilates, Salicylates, cinnamic acid derivatives, dihy herein can include, in addition to excipients, the salicylic acid droxycinnamic acid derivatives, trihydroxycinnamic acid and Salicylates, and the Zinc oxide and/or titanium dioxide, derivatives, hydrocarbons, dibenzalacetone and benzalac other active agents. These agents, and their relative weight etophenone, naphthosulfonates, dihydroxy-naphtholic acid percentages in the formulation, are listed in Table 2 below. and its salts, o- and p-hydroxy-biphenyldisulfonates, cou These components can help to boost treatment of the acne marin derivatives, diazoles, quinine salts, quinoline deriva condition, or can have additional beneficial properties. tives, hydroxy or methoxy Substituted benzophenones, uric 0051 One example of an additional component is Active(R) and vilouric acids, tannic acid and its derivatives, hydro Powder Purity LS 9695 by Cognis Corporation. Active(R) quinone, benzophenones, and the like. Powder Purity (also referred to herein as AP Purity) is com 0044 Also useful herein are sunscreening actives. A wide posed of B vitamins, panthenol, biotin, and niacinamide, and variety of sunscreening agents are described in U.S. Pat. No. various extracts to regulate sebum, inhibit lipogenesis, and 5,087,445, to Haffey et al., issued Feb. 11, 1992; U.S. Pat. No. provide an anti-inflammatory effect. In a 4 week clinical 5,073,372, to Turneret al., issued Dec. 17, 1991; U.S. Pat. No. study evaluating the active fraction of Active R. Powder Purity, 5,073,371, to Turner et al. issued Dec. 17, 1991. the results showed a 16.6% decrease in the number of active 0045. Non-limiting examples of sunscreens which are sebaceous glands and a 21.6% decrease in seborrheic flux useful in the compositions of the present invention are those after treatment. Furthermore, in vitro testing on human fibro selected from the group consisting of 2-ethylhexyl p-meth blasts confirmed that this active fraction reduced excess oxycinnamate, 2-ethylhexyl N,N-dimethyl-p-aminoben sebum secretion via inhibition of 5C-reductase enzyme, and Zoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sul this effect increased with duration and concentration of treat fonic acid, octocrylene, oxybenzone, homomethyl salicylate, ment. 5C.-Reductase converts testosterone to dihydrotest octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, osterone (DHT) in sebaceous cells. DHT stimulates sebum 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, secretion, and, thus, inhibiting its production will reduce 3-(4-methylbenzylidene)camphor, titanium dioxide, Zinc sebum levels. oxide, silica, iron oxide, and mixtures thereof. Still other 0.052 Active(R) Powder Purity includes a significant useful sunscreens are those disclosed in U.S. Pat. No. 4,937, amount of water-based active specifically designed to control 370, to Sabatelli, issued Jun. 26, 1990; and U.S. Pat. No. sebum regulation and inhibit lipogenesis. Because of the 4,999,186, to Sabatelli et al., issued Mar. 12, 1991; these two encapsulation process, AP Purity can be formulated into all references are incorporated by reference herein in their anhydrous systems such as loose and pressed powders, hot entirety. Still other useful sunscreens include aminobenzoic pour sticks and silicone-based serums. It is designed to treat acid (PABA), benzylidene camphor, butyl methoxy diben oily, troubled and/or blemished skin, and is perfectly suited Zoyl methane, diethanolamine p-methoxycinnamate, dioxy for acne preparations. benzone, ethyl dihydroxypropyl (PABA), glyceryl ami 0053 Although the exact amounts of each active are not nobenzoate, homomethyl salicylate, isopropyl dibenzoyl listed here, the components include water, lauryl methacy methane, lawsone and dihydroxyacetone, menthyl anthra late/glycol dimethacrylate crosspolymer, dicaprylyl ether, nilate, methyl anthranilate, methyl benzylidene camphor, niacinamide, yeast extract, Aesculus Hippocastanum (Horse octocrylene, octyl dimethyl (PABA), octyl methoxycin Chestnut) seed extract, titanium dioxide, algae extract, namate, oxybenzone, 2-phenylbenzimidazole-5-Sulfonic ammonium glycyrrhizate, panthenol, Zinc gluconate, caf acid, red petrolatum, Sulisobenzone, titanium dioxide, tri feine, Xanthan gum, polyglyceryl-2-dipolyhydroxyStearate, ethanolamine Salicylate, Zinc oxide, and mixtures thereof. and biotin Especially preferred examples of these Sunscreens include 0054 Zinc gluconate is another optional component, and those selected from the group consisting of 4-N,N-(2-ethyl further Supports sebum regulation and antimicrobial activity. hexyl)methylaminobenzoic acid ester of 2,4-dihydroxyben Both Zinc and gluconate ions are intimately involved in skin Zophenone, 4-N,N-(2-ethylhexyl)methylaminobenzoic acid metabolism and provide a Soothing, anti-inflammatory effect. ester with 4-hydroxydibenzoylmethane, 4-N,N-(2-ethyl 0055 Pearl powder can also be used. Pearl powder hexyl)-methylaminobenzoic acid ester of 2-hydroxy-4-(2- includes many beneficial ingredients, such as amino acids, hydroxyethoxy)benzophenone, 4-N,N-(2-ethylhexyl)-me Some of which cannot be synthesized in the human body, and thylaminobenzoic acid ester of 4-(2-hydroxyethoxy) bio-available minerals, including calcium, magnesium, and dibenzoylmethane, and mixtures thereof. Selenium. Used since ancient times, particularly in Chinese US 2010/0183528 A1 Jul. 22, 2010

medicines, it is believed to enhance moisturization, exfolia product performance, provide long lasting odor or flavor per tion, skin repair, and UV protection. Pearl Powder has been ception, and signal that a new application of the product is used for helping to treat blemishes, pigmentation disorders, needed. and restoring proper barrier function. It has been shown to 0.066 Conventional fragrance ingredients and perfume reduce Transepidermal Water Loss (TEWL), the amount of ingredients can be used in the release system of the present water passively diffusing through the stratum corneum and a invention. Selection of any perfume component, or amount of direct correlation to barrier intactness. perfume, is based on functional and aesthetic considerations. 0056 Bamboo extract can also be used. Bamboo extract Examples of usable fragrance and flavor compounds dis offers gentle exfoliation by removing dead cells and debris cussed hereinafter, along with their odor characters, and their from the skin Surface. A clinical study evaluating the ingre physical and chemical properties, are given in "Perfume and dient’s efficacy showed a significant exfoliating effect after Flavor Chemicals (Aroma Chemicals), Steffen Arctander, only 14 days of use. published by the author, 1969, and in “Common Fragrance 0057 Pigments/Colorants and flavor Materials-Preparation, Properties and Uses'. Kurt 0058 Other additives that can be added to the present Bauer and Dorotea Garbe, published by VCH Verlagsgesell invention include dispersed inorganics (colorants) and pig schaft mbH, 1985, incorporated herein by reference. ments. Such dispersed inorganics and pigments include, but 0067. Botanical extracts are oak bark extract, walnut are not limited to, fumed silica, microfine pigments, particu extract, tincture of arnica, hamamelis extract, ribwort extract, larly oxides and silicates, e.g. iron oxide, particularly coated pansy extract, thyme or sage extract; for the treatment of iron oxides, and/or titanium dioxide, and ceramic materials damaged or injured skin, for example, St. John's wort tinc Such as boron nitride, or other solid components such as ture, cone flowers tincture, chamomile flowers extract, or barium sulfate, bismuth oxychloride, and mica. calendula flowers tincture; and for the care of exhausted and 0059 Representative Formulation damaged skin, for example, birch leaves extract, nettle 0060. In one embodiment, the formulation includes Iron extract, coldsfoot extract, comfrey tincture, horsetail extract, Oxides, Bismuth Oxychloride, & Mica as colorants, titanium or aloe Vera extract. Vegetable preparations may also be dioxide and Zinc oxide as physical Sunscreens, Poly-Pore released from the film layer for the intradermal treatment of 450SA (salicylic acid and allyl methacrylate crosspolymer) diseases, for example, extracts of horse chestnut and butch as a salicylic acid sustained-release formulation, ABS White er's broom in case of vein diseases, or extracts and tinctures of Willow Bark Extract Powder and PhytoCide Aspen Bark arnica, calendula, and capsicum in case of contusions, distor Extract Powder as sources of salicylate, zinc gluconate, tions, or haemorrhages. Vegetable preparations in the system, Active R. Powder Purity LS 9695, Bambusa Arundinacea according to the present invention may also be used in trans Stem Powder, PPP-100 Pearl Powder, and one or more of dermal therapy, for example, ginseng extract in case of geri dicaprylyl ether, niacinamide, yeast extract, Aesculus Hip atric complaints; Valerian tincture, extracts of melissa and pocastianum (Horse Chestnut) seed extract, algae extract, hop to cause a sedative effect in case of Superexcitation, sleep ammonium glycyrrhizate, panthenol, caffeine, Xanthan gum, disturbances, and stress; extracts of kola and tea to achieve a polyglyceryl-2 dipolyhydroxyStearate, and biotin. stimulative effect; or hawthorn extract to stabilize the circu 0061 Additional Optional Active Agents latory system. 0062. The controlled release system described herein 0068 Preservatives includes Salicylic acid as a primary active agent, naturally 0069 Preservatives can desirably be incorporated into the occurring or purified salicylates, and Zinc oxide and/or tita dry powder foundation described herein to protect against the nium dioxide as Sunblocking agents, in the form of a dry growth of potentially harmful microorganisms. While micro powder foundation. organisms tend to grow in the aqueous phase, microorgan 0063. The foundation can also include, in addition to these isms can also reside in the anhydrous or oil phase. As such, agents, other cosmetic, dermatological, and pharmaceutical preservatives which have solubility in both water and oil are active agents, including, but are not limited to: anti-oxidants; preferably employed in the present compositions. Suitable free radical Scavengers; depigmentation agents; reflectants; preservatives for compositions of the present invention are antimicrobial (e.g., antibacterial) agents; allergy inhibitors; alkyl esters of para-hydroxybenzoic acid. Other preserva anti-aging agents; anti-Wrinkling agents, antiseptics; analge tives, which can be used include hydantoin derivatives, pro sics; anti-inflammatory agents; fresheners; healing agents; pionate salts, and a variety of quaternary ammonium com anti infectives; inflammation inhibitors; vasoconstrictors; pounds. vasodilators; wound healing promoters; peptides, polypep 0070 Appropriate preservatives can be selected to satisfy tides and proteins; skin lightening agents; antifungals; coun the preservative challenge test and to provide product stabil terirritants; make-up preparations; vitamins; amino acids and ity. Particularly preferred preservatives are methylparaben, their derivatives; herbal extracts; flavoids; sensory markers imidazolidinyl urea, sodium dehydroacetate, propylparaben, (i.e., cooling agents, heating agents, etc.); skin conditioners; trisodium ethylenediamine tetraacetate (EDTA), and benzyl chelating agents; cell turnover enhancers; nourishing agents; alcohol. The preservative can be selected based on the con moisture absorbers; sebum absorbers and the like: skin pen sideration of possible incompatibilities between the preser etration enhancers; and other active ingredients. Vative and other ingredients in the release system. 0064. Fragrances and Sensory Markers 0071 Preservatives are preferably employed in amounts 0065. The formulation described herein also provides syn ranging from about 0.01% to about 2% by weight of the chronizing the release of the sensory markers such as fra composition. grances, flavors, cooling agents, such as menthol derivatives, 0072 Vitamins and heating agents, such as capsaicin. The release of the 0073. Various vitamins can be included in the dry powder sensory markers can be used to convey to the consumer the foundation described herein. For example, vitamin A and US 2010/0183528 A1 Jul. 22, 2010

derivatives thereof, vitamin B2, biotin, pantothenic acid, vita oil; peony root; 1.2 pentandiol; PHENONIP (available from min K, vitamin D, vitamin E and mixtures thereof can be Nipa Labs, located in Wilmington, Del.); phenoxyethanol: used. phytosphingosine; pine needle oil; PLANSERVATIVE (available from Campo Research); propyl paraben; purslane; 0074 Antimicrobial and Antifungal Actives quillaira, rhubarb; rose geranium oil; rosemary; Sage; Sali 0075 Antimicrobial and antifungal actives can be effec tive to prevent the proliferation and growth of bacteria and cylic acid; Sassafras; Savory; Sichuan lovage; Sodium meta fungi and can be used in the dry powder foundation described bisulfite: sodium sulfite; SOPHOLIANCE (available from herein. Non-limiting examples of antimicrobial and antifun Soliance, located in Compiegne, France); Sorbic acid and its galactives include beta-lactam drugs, quinolone drugs, cipro salts; sphingosine; Stevia; Storax; Sucrose esters; tarmic acid; floxacin, norfloxacin, tetracycline, erythromycin, amikacin, tea; tea tree oil (cajeput oil); thyme; triclosan; triclocarban; 2,4,4-trichloro-2'-hydroxy diphenyl ether, 3,4,4-trichlo tropolone; turpentine; umbelliferone (antifungal), yucca, and robanilide, phenoxyethanol, phenoxy propanol, phenoxyiso mixtures thereof. propanol, doxycycline, capreomycin, chlorhexidine, chlo 0076 Anti-Inflammatory Agents rtetracycline, oxytetracycline, clindamycin, ethambutol, 0077 Anti-inflammatories can be included in dry powder hexamidine isethionate, metronidazole, pentamidine, gen foundation described herein to enhance photoprotection ben tamicin, kanamycin, lineomycin, methacycline, meth efits, particularly from UVA. enamine, minocycline, neomycin, netilmicin, paromomycin, 0078 Suitable steroidal anti-inflammatories include streptomycin, tobramycin, miconazole, tetracycline hydro hydrocortisone; non-steroidal anti-inflammatories such as chloride, erythromycin, Zinc erythromycin, erythromycin oxicans, Salicylates, acetic acid derivatives, fenamates, pro estolate, erythromycin Stearate, amikacin Sulfate, doxycy pionic acid derivatives, pyrazoles, Substituted phenyl com cline hydrochloride, capreomycin Sulfate, chlorhexidine glu pounds, 2-naphthyl containing compounds, and natural anti conate, chlorhexidine hydrochloride, chlortetracycline inflammatories such as aloe Vera. Examples of anti hydrochloride, oxytetracycline hydrochloride, clindamycin inflammatories are described in U.S. Pat. No. 5,487,884, the hydrochloride, ethambutol hydrochloride, metronidazole entire contents of which are incorporated herein by reference. hydrochloride, pentamidine hydrochloride, gentamicin Sul (0079 Anti-Wrinkle, Anti-Skin Atrophy and Skin Repair fate, kanamycin Sulfate, lineomycin hydrochloride, methacy Actives cline hydrochloride, methenamine hippurate, methenamine 0080 Anti-wrinkle, anti-skin atrophy and skin repair mandelate, minocycline hydrochloride, neomycin Sulfate, actives can be effective in replenishing or rejuvenating the netilmicin sulfate, paromomycin sulfate, streptomycin sul epidermal layer and can be included in dry powder foundation fate, tobramycin Sulfate, miconazole hydrochloride, amanfa described herein. These actives generally provide these desir dine hydrochloride, amanfadine Sulfate, octopirox, parachlo able skin care benefits by promoting or maintaining the natu rometa Xylenol, nystatin, tolnaftate, Zinc pyrithione; ral process of desquamation. clotrimazole; alantolactone; isoalantolactone; alkanet extract I0081. Nonlimiting examples of anti-wrinkle and anti-skin (alaninin); anise; arnica extract (helenalin acetate and 11.13 atrophy actives include Vitamin B3 compounds (such as dihydrohelenalin); Aspidium extract (phloro, lucinol contain niacinamide and nicotinic acid), Salicylic acid and derivatives ing extract); barberry extract (berberine chloride); bay sweet thereof (such as 5-Octanoyl salicylic acid, heptyloxy 4 Sali extract; bayberry bark extract (myricitrin); benzalkonium cylic acid, and 4-methoxy Salicylic acid); Sulfur-containing D chloride; benzethonium chloride; benzoic acid and its salts; and Lamino acids and their derivatives and salts, particularly benzoin; benzyl alcohol; blessed thistle; bletilla tuber; bloo the N-acetyl derivatives, a preferred example of which is droot; bois de rose oil; burdock; butyl paraben; cade oil; CAE N-acetyl-L-cysteine; thiols, e.g. ethane thiol: hydroxy acids, (available from Ajinomoto, located in Teaneck, N.J.), cajeput phytic acid, lipoic acid; lysophosphatidic acid; skin peel oil; Cangzhu, capsicum frutescens extract; caraway oil; cas agents (e.g., phenol and the like); Actein 27-Deoxyactein carilla bark (sold under the tradename ESSENTIAL OIL); Cimicifugoside (available from Cirnigoside); adapalene; cedarleaf oil; chamomille; chaparral; chlorhexidine glucon ademethionine; adenosine; aletris extract; alkyl glutathione ate; chlorophenesin; chlorXylenol; cinnamon oil; citronella esters; alkoxyalkoxy alkoxyn benzoic and derivatives; aloe oil; clove oil; Crinipan AD (available from Climbazole); 2.3- derived lectins; amino propane phosphoric acid; 3-aminopro dihydro-farnesol; dehydroacetic acid and its salts; dill seed pyldihydrogen phosphate; Amadorine (available from Barnet oil; DOWICIL 200 (available from Dow Chemical, located in Products); anise extracts; AOSINE (available from Secna); Midland, Mich.); echinacea; elenolic acid; epimedium; ethyl arginine amino benzoate; ASC III (available from E. Merck, paraben: Fo-Ti; galbanum; garden bumet: GERMALL 115 located in Darmstadt, Germany); ascorbic acid; ascorbyl and GERMALL II (available from ISP-Sutton Labs, located palmitate; asiatic acid; asiaticosides; ARLAMOL GEOTM in Wayne, N.J.); German chamomile oil; giant knotweed; (available from ICI, located in Wilmington, Del.); azaleic GLYDANT (available from Lonza, located in Fairlawn, N.J.); acid; benzoic acid derivatives; bertholletia extracts; betulinic GLYDANT PLUS (available from Lonza); grapefruit seed acid; BIOCHANIN A AND BIOPEPTIDE CL (available oil; 1.6 hexanediol; hexamidine diisethionate; hinokitiol; from Sederma, located in Brooklyn, N.Y.); BIOPEPTIDEEL honey; honeysuckle flower, hops; immortelle; iodopropynl (available from Sederma); biotin; blackberry bark extract; butyl carbamide (available from Lonza); isobutyl paraben; blackberry lily extracts; black cohosh extract; blue cohesh isopropyl paraben; JM ACTICARE (available from Micro extract; butanoyl betulinic acid; carboxymethyl 1.3 beta glu bial Systems International, located in Nottingham, NG);juni can; catecholamines; chalcones; citric acid esters; chaste tree per berries; KATHON CG (available from Rohm and Haas, extract; clover extracts; coumestrol: CPC Peptide (available located in Philadelphia, Pa.): kojic acid; labdanum; lavender; from Barnet Products); daidzein, dang gui extract; daruto lemon balm oil; lemon grass; methyl paraben; mint, mume; side; debromo laurinterol. 1-decanoyl-glycero-phosphonic mustard; myrrh, neem seed oil; ortho phenyl phenol; olive acid; dehydrocholesterol; dehydrodicreosol, dehydrodieu leaf extract (available from Bio Botanica); parsley; patchouly genol; dehydroepiandersterone; DERMOLECTINE (avail US 2010/0183528 A1 Jul. 22, 2010

able from Sederma); dehydroascorbic acid; dehydroepian able from Cosmoferm, located in Deft, Netherlands); CERA dersterone sulfate; diamethole; hydroxy benzoic acid; 2.4 MIDE LS 3773 (available from Laboratories Serobi dihydroxybenzoic acid; diglycol guanidine Succinate; dioS ologiques); CERAMINOL (available from Inocosm); genin; disodium ascorbyl phosphate; dodecanedioic acid; Cerasol and Cephalip (both available from Pentapharm); cho Ederline (available from Seporga); Enderline (available from lesterol: cholesterol hydroxystearate; cholesterol isostearate; Laboratories Seporga); equol; eriodictyol; estrogen and its 7 dehydrocholesterol: DERMATEIN BRC and DER derivatives; ETF (available from Laboratories Seporga); MATEIN GSL (both available from Hormel); ELDEW CL ethocyn; ELESERYL SH (available from Laboratories Sero 301 AND ELDEW PS203 (both available from Ajinomoto): biologiques, located in Somerville, N.J.); ENDONUCLEINE Fitobroside (available from Pentapharm); galactocerebro (available from Laboratories Serobiologiques); ergosterol; sides; Generol 122 (available from Henkel); glyceryl serine eythrobic acid; fennel extract; fenugreek seed extract; amide; hydroxyethyl isostearyl isopropanolamine; lactic FIBRASTIL (available from Sederma); FIBROSTIM acid; Lactomide (available from Pentapharm): lanolin; lano ULINESS and P (available from Sederma); FIRMOGEN LS lin alcohols; lanosterol; lauric acid N laurylglucamide; lipoic 8445 (available from Laboratories Serobiologiques); for acid; N-acetyl cysteine; N-acetyl-L-serine; N-methyl-L- mononetin; forsythia fruit extract; gallic acid esters; gamma Serine; Net Sterol-ISO (available from Barnet Products): aminobutyric acid; GATULINE RC (available from Gattle vitamin B compounds (such as niacinamide and nicotinic fosse, located in Priest, France); genistein; genisteine; genis acid); palmitic acid; panthenol; panthetine; phosphodi tic acid; gentisyl alcohol; gingko billboa extracts; ginseng esterase inhibitors: PHYTO/CER (available from Intergen); extracts: ginsenoside (RO, R61, R62, R63, Rc, RD, RE, RF, phytoglycolipid millet extract (available from Barnet Prod RF-2, RG-I, RG-2); gluco pyranosyl-L-ascorbate; glu ucts Distributer, located in Englewood, N.J.); PHYTOSPH tathione and its esters; glycitein; hesperitin; hexahydro cur INGOSINE (available from Gist Brocades, located in King of cumin; HMG-coenzyme A reductase inhibitors; hops Prussia, Pa.); PSENDOFILAGGRIN (available from Brooks extracts; 11 hydroxy undecanoic acid; 10 hydroxy decanoic Industries, located in South Plainfield, N.J.); QUESTAMIDE acid; 25-hydroxycholesterol; 7-hydroxylated sterols: H (available from Quest); serine; sigmasterol; sitosterol; soy hydroxyethyl isostearyloxy isopropanolamine; hydroxy-tetra bean derived sterols; sphingosine; sphingomylinase; S-lac methyl piperidinyloxy; hypotaurine; ibukijakou extract; toyl glutathione; stearic acid; Structurine (available from isoflavone SG 10 (available from Barnet Products): kinetin: Silah); SUPER STEROL ESTERS (available from Croda): kohki extract; L-2-OXO-thiazolidine-4-carboxylic acid thioctic acid: THSC CERAMIDE OIL (available from esters; lactate dehydrogenase inhibitors: 1-lauryl, -lyso-phos Campo Research); trimethyl glycine; tocopheryl nicotinate; phatidylcholine; lectins; lichochalcone LF15 (available from vitamin D;Y2 (available from Ocean Pharmaceutical); and Maruzen); licorice extracts; lignan, lumisterol; lupenes; mixtures thereof. luteolin; lysophosphitidic acid; magnesium ascorbyl phos I0084. Non-Steroidal Cosmetic Soothing Actives phate; margin; melatonin; melibiose; metalloproteinase I0085 Cosmetic soothing actives can be effective in pre inhibitors; methoprene; methoprenic acid; mevalonic acid; venting or treating inflammation of the skin and can be MPC COMPLEX (available from CLR); N methyl serine; N included in the dry powder foundation described herein. The methyl taurine; N. NI-Ws (lactyl) cysteamin; naringenin: Soothing active enhances the skin appearance benefits of the neotigogenin; o-desmethylangoiensin; oat beta glucan, ole present invention, e.g., Such agents contribute to a more uni anolic acid; pantethine; phenylalanine; photoanethone; pip form and acceptable skin tone or color. eridine; placental extracts; pratensein, pregnenolone; preg I0086. The exact amount of anti-inflammatory agent to be nenolone acetate; pregnenolone Succinate; premarin: quillaic used in the compositions will depend on the particular anti acid; raloxifene; REPAIR FACTOR1 and REPAIR FACTOR inflammatory agent utilized since Such agents vary widely in FCP (both available from Sederina); retinoates (esters of C2. potency. alcohols); retinyl glucuronate; retinyl linoleate; S-car I0087. Non-limiting examples of cosmetic soothing agents boxymethyl cysteine; SEANAMINE FP (available from include the following categories: propionic acid derivatives; Laboratories Serobiologiques); sodium ascorbyl phosphate: acetic acid derivatives; fenamic acid derivatives; biphenylcar Soya eXtracts; spleen extracts; tachysterol; taurine; tazaro boxylic acid derivatives; and oxicams. All of these cosmetic tene; tempol; thymulen; thymus extracts; thyroid hormones; soothing actives are fully described in U.S. Pat. No. 4,985, tigogenin; tocopheryl retinoate; toxifolin; traumatic acid; tri 459 to Sunshine et al., issued Jan. 15, 1991, incorporated by choline citrate; trifoside; uracil derivatives: ursolic acid; vita reference herein in its entirety. Non-limiting examples of min D3 and its analogs; vitamin K. Vitex extract; yam extract; useful cosmetic Soothing actives include acetyl salicylic acid, yamogenin: Zeatin; and mixtures thereof. ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenopro I0082 Skin Barrier Repair Actives fen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, 0083 Skin barrier repair actives are those skin care actives oxaprozin, pranoprofen, miroprofen, tioxaprofen, Suprofen, which can help repair and replenish the natural moisture alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, barrier function of the epidermis and can be included in dry absinthium, acacia, ACTIGEN Y (available from Active powder foundation described herein. Non-limiting examples Organics), aescin, agrimony, alder buckthorn extract, allan of skin barrier repair actives include Alpha Lipid (available toin, aloe, angelica, APT (available from Centerchem), from Lucas Meyer); ascorbic acid; biotin: biotin esters; bras arnica, astragalus, astragalus root extract, AVOCADIN sicasterol; caffeine; campesterol; canola derived sterols; Cen HS-80 (available from Croda), avocado, azulene, Baicalin SR namides (available from Ennagram); Ceramax (available 15 (available from Barnet Products Dist.), baikal skullcap. from Alban Muller); CERAMAX (available from Quest, baizhu, balm mint, balm of gilead, balsam canada, barley located in Ashford, England); CERAMIDE 2 and CERAM malt, basil, bayberry fruit, bee pollen, bladderwrack, BIO IDE HO3TM (both available from Sederma); CERAMIDE 11 DYNESTRF (available from Arch Personal Care), BIOPHY (available from Quest); CERAMIDE III and IIIB (both avail TEX (available from Laboratories Serobiologiques), bisab US 2010/0183528 A1 Jul. 22, 2010

olol, black cohosh, black cohosh extract blue cohosh, blue 0088 Skin Lightening Actives cohosh extract, blue flag, boneset, borage, borage oil, brady I0089. Skin lightening actives can actually decrease the kinin antagonists, bromelain, burdock root, butterbur, calen amount of melanin in the skin or provide Such an effect by dula, calendula extract, Canadian Willowbark Extract (avail other mechanisms and can be included in the dry powder able from Fytokem), candelilla wax, Cangzhu, canola foundation described herein. Skin lightening actives suitable phytosterols, capsicum, carboxypeptidase, celery seed, cel for use herein are described in co-pending patent application ery stem extract, CENTAURIUM (available from Sederma), Ser. No. 08/479,935, filed on Jun. 7, 1995 in the name of centaury extract, chamaZulene, chamomile, chamomile Hillebrand, corresponding to PCT Application No. U.S. Ser. extract, chaparral, chaste tree, chaste tree extract, chickweed, No. 95/07432, filed Jun. 12, 1995; and copending patent chicory root, chicory root extract, chirata, chishao, collodial application Ser. No. 08/390, 152, filed on Feb. 24, 1995 in the oatmeal, coltsfoot, comfrey, comfrey extract, coneflower, names of Kalla L. Kvalnes, Mitchell A. DeLong, Barton J. cornflower, CROMOIST CM GLUCAN (available from Bradbury, Curtis B. Motley, and John D. Carter, correspond Croda), CYTOBIOL. IRIS A (available from Gattefosse), ing to PCT Application No. U.S. Ser. No. 95/02809, filed Mar. darutoside, dehurian angelica, devil's claw, divalent metals 1, 1995, published Sep. 8, 1995; all incorporated herein by (Such as, magnesium, strontium, and manganese), doggrass, reference. dogwood, dong quai, Eashave (available from Pentapharm), 0090. Non-limiting examples of skin lightening actives eleuthero, ELHIBIN (available from Pentapharm), useful herein include ACTIWHITE LS 98.08 (available from ENTELINE 2 (available from Secna), ephedra, epimedium, Cognis), adapalene, almond extract, aloe extract, alpha-gly esculoside; ethacrynic acid, evening primrose, eyebright, caryl-L-ascorbic acid, aminotyroXine, ammonium lactate, Extract LE-100 (available from Sino Lion), Fangfeng, fennel anethole derivatives, apple extract, arbutin, areca catechu L. seed extract, feverfew, ficin, fir needle, forsythia fruit, extract, ascorbic acid, ascorbyl palmitate, azelaic acid, bam Fytosterol 85 (available from Fytokem), ganoderma, gaoben, boo extract, bearberry extract, BELIDES (NP) (available gardenia, Gatuline A (available from Gattefosse), gentian, from CLR Chemisches Laboratorium Dr. Kurt Richter germanium extract, gingko billboa extract, ginkgo, ginseng GmbH), bletilla tuber, bupleurum falcatum extract, burnet extract, GIVOBIOGZn (available from Seppic), goldenseal, extract, Burnet Power (available from Barnet Products), butyl gorgonian extract, gotu kola, grape fruit extract, guaiac Wood hydroxy anisol, butyl hydroxy toluene, butyl resoreinol, oil, guggal extract, helenalin esters, henna, honeysuckle Chuanxiong, cola decaballo extract, Dang-Gui, deoxyarbu flower, hops, horehound extract, horsechestnut, horsetail, tin, DERMAWHITE NFLS 9410 (available from Cognis), huzhang, hypericum, Iceland moss, ichthyol, immortelle, 1.3 diphenyl propane derivatives, 2.5 dihydroxybenzoic acid ipecac, IRICALMIN (available from Pentapharm), irish and its derivatives, 2-(4-acetoxyphenyl)-1.3 dithane, 2-(4- moss, ivy, Japanese green tea, job's tears, jojoba, jujube, hydroxyphenyl)-1,3 dithane, elder flower, ellagic acid, juniper berry, kava kava, kiwi, kola extract, kumquat, EMBILICA (available from EMD/Rona), escinol, estragole LANACHRYS 28 (available from Lana Tech), lemon oil, derivatives, esculoside, esculetin, ETIOLINE (available from LEMON SECRETS (available from Gattefosse), lianqiao, Croda), FADEOUT (available from Pentapharm), Fangfeng, licorice root, ligusticum, ligustrum, lime flower, linden, fennel extract, FISIONSKIN LIGHT (available from Tri-K), lovage root, luffa, mace, magnolia flower, mandarin orange, gallic acid and its derivatives, ganodenna extract, gaoben, manjistha extract, margaspidin, marshmallow, matricin, GATULINE WHITENING (available from Gattlefosse), meadowsweet, melatonin, MICROAT IRC (available from genistic acid and its derivatives, gentisyl alcohol, Nurture), mints, mistletoe, Modulene (available from GIGAWHITE (available from Pentapharm), glabridin and its Seporga), mono or diglucosides of glabridin, mono or diglu derivatives, gluco pyranosyl-1-ascorbate, gluconic acid, glu cosides of gentisin, MTA (5'-deoxy-5'-methylhioadenosine), cosamine, glycolic acid, glycyrrhizinic acid, green tea mulberry bark, mullein, mung bean extract, musk, myrrh, extract, horseradish, 4-Hydroxy-5-methyl-32H-furanone, N-methyl arginine, nettle, neutral henna, oak bark, oat beta hydroquinone, 4 hydroxyanisole and its derivatives, 4-hy glucan, oat extract, orange, orange blossom, panthenol, droxybenzoic acid derivatives, hydroxycaprylic acid, hyptis papain, papaya, parsley, passion fruit, pear, periwinkle, pine extract, inositolascorbate, kojic acid, kojic dipalmitate, lactic cone, phenoxyacetic acid, peony bark, peony root, Phytople acid, lemon extract, licorice extract, Licorice P-TH (available nolin (available from Bio Botanica), phytosphingosine, from Barnet Products), linoleic acid, magnesium ascorbyl plankton, Preregen (available from Pentapharm), prickly ash phosphate, MELACLEAR 2 (available from Croda), Melfade bark, purslane, QUENCH T (available from Centerchem), (available from Pentapharm), MELAWHITE (available from quillaia, red clover blossom, red sage, rehmannia, rhubarb, Pentapharm), Melanostatine DM (available from Laborato rice bran, roman chamomile, rose, rosemary, roSmarinic acid, ries Seporga), morus alba extract, mulberry root extract, NAB royal jelly, rue, rutin, Sandlewood, Sandi, Sarsaparilla, saw ASAFETIDA EXTRACT (available from Arch Personal palmetto, SENSILINE (available from Silab), SEPICALMS Care), niacinamide, 5-octanoyl salicylic acid, papaya, parsley (available from Seppic), SEPICALM VG (available from extract, phellinus linteus extract, pinon blanco extract, pinon Seppic), SIEGESBECKIA (available from Sederma), skull negro extract, piri-piri extract, pyrogallol derivatives, retinoic cap, slippery elm, soap bark, spearmint, SPHINGANINE acid, retinol, retinyl esters (acetate, propionate, palmitate, (available from Croda), stearyl glycyrrhetinate, Stimutex linoleate), 2.4 resorcinol derivatives, 3.5 resorcinol deriva (available from Pentapharm), storax, strontium nitrate, Sweet tives, rose fruit extract, rucinol, salicylic acid, SEPIWHITE birch oil, Sweet woodniff, tagetes, tea extract, thyme extract, MSH (available from Seppic), Song-Yi extract, Sophora tienchiginseng, tocopherol, tocopheryl acetate, triclosan, tur Powder (available from Barnet Products), SYNERLIGHT meric, urimei, ursolic acid, VEDACALM (available from (available from Gattefosse), 4-thioresorein, 34.5 trihydroxy Gattefosse), violet, white lily, white pine bark, wild cherry benzyl derivatives, tranexamic acid, tyrostat (Rumex Extract bark, witch hazel, yarrow, yeast extract, yucca, and mixtures available from Fytokem), Tyroslat 10.11 (available from thereof. Fytokem), VAMAWHITE GT (available from Tri-K), vanilla US 2010/0183528 A1 Jul. 22, 2010

derivatives, vitamin D3 and its analogs, and mixtures thereof, Amerchol); Easy lift (available from Tri-K), egg albumen; WHITAMI (available from Alban Muller). Fision Skin Lift (available from Tri-K), Fision Soylift (avail 0091 Sebum Stimulators able from Tri-K), Flexan 130 (available from National 0092 Sebum simulators can increase the production of Starch); Gatuline Lifting (available from Gattefosse); Pentac sebum by the sebaceous glands and can be included in the dry are HP (available from Pentapharm); Pepha-Tight (available powder foundation described herein. These skin care actives from Pentapharm), Quicklift (available from BASF), are especially useful for post menopausal women who are Sesaflash (available from Seppic), Skin Tightening ST (avail sebum deficient. Nonlimiting examples of sebum stimulating able from Croda), Soytensor LS 9811 (available from Cog actives include bryonolic acid, completech MBAC-DS, dehy nis), Tritisol (available from Croda), Vegeseryl (available droetiandrosterone (also known as DHEA), orizanol and mix tures thereof. from Laboratories Serobioloques) and mixtures thereof. 0093 Sebum Inhibitors 0101 Anti-Itch Ingredients 0094. Sebum inhibitors can decrease the production of 0102 Also useful as active ingredients in the present sebum by the sebaceous glands and can be included in the dry invention are anti-itch ingredients. powder foundation described herein. Non-limiting examples 0103) Non-limiting examples of anti-itch ingredients of sebum inhibiting actives include AC.NET (available from which are useful in the compositions of the present invention Croda), ALMETH (available from Tri-K), aluminium are those selected from the group consisting of aloe Vera, hydroxy chloride, ASEBIOL (available from Laboratories balm of gilead, beet, pennyroyal, peppermint, soapwort, Serobiologiques), BIODERMINE (available from Sederma), Stimu-tex (available from Pentapharm); Takanal (available climbazole, COMPLETECH MBAC-OS (available from from Ikeda-Distributer); Ichthyol (available from Interna Lipo), corticosteroids, cucumber extracts, dehydroacetic acid tional Sourcing-Distributor); Oxygenated Glyceryl Triesters and its salts, dichlorophenyl imidazoldioxolan (available from Elubiol), GIVOBIOGZn (available from Seppic), gug (available from Seporgia) and mixtures thereof. ulipiu, ketoconazole, Lichochalcone LR 15 (available from 0.104 Antioxidants Maruzen), niacinamide, phloretin, PHLOROGINE (available 0105 Representative antioxidants include vitamin E, from Secna), Phycosaccharide Anti-Acne (available from tocopheryl acetate, betaglucan, coenzyme Q10, butylated Codif), PHYTOTAL OS (available from Croda), REGU-SEB hydroxy toluene (BHT), butylated hydroxy anisole (BHA), (available from Pentapharm), S-carboxylmethyl cysteine, Superoxide dismutase, propylgallate, and the like. SEBORAMI (available from Alban Muller), SEPICON TROL AS (available from Seppic), spironolactone, tiox II. Processing Method olone, tocopherol, tranexamic acid, LTNITRIENOL T27 (available from Unichem), INIREDUCE R #% (available 0106 The formulation described herein can be prepared from Induchem USA), Zincidone (UC1 B), and mixtures by combining the various actives and excipients, and blend thereof. ing the resulting mixture. Particle size selection can be 0095 Protease Inhibitors accomplished by Screening, air stream segregation, and the 0096. Also useful as active ingredients in the present like. invention are protease inhibitors. 0107 A flow agent is optionally added after the powder is 0097. Non-limiting examples of protease inhibitors which manufactured. Flow agents which can be used in the present are useful in the compositions of the present invention are invention can be silica, clay, starch, and the like which can be those selected from the group consisting of A E Complex added to the particles. Suitable fine silica materials are com (available from Barnet Products); ALE (available from Seporga); allicin; alpha lupaline: Aosaine (available from mercially available as pyrogenic or fumed silica, such as Secma); Aprotinin (available from Pentapharm); areca cat materials sold under Trade names of Cabosil manufactured echu (Betel Nut) extract; areca catechu extracts; Blue Algae by G. L. Cabot Inc., Aerogel 500 manufactured by J. M. Extract (available from Collaborative Labs); Centaurium Huber Corp., Syloid 244-63-65 manufactured by W. R. (available from Sederma); cholesterol sulfate; CMST (avail Grace and Co., Li-sil 233 manufactured by Pittsburg Plate able from Bioetica); Dermoprotectine (available from Sed Glass Co., and Sipernat D-17 manufactured by Degussa Co. erma); Disacoside HF 60 (available from Barnet Products); Suitable clay materials include kaolinites and bentonites, as Elhibin (available from Pentapharm); Fluid Out Colloid described in British Patent No. 1460, 646. (available from Vegetech); Hypotaurine (available from Sogo 0108. The invention can be further illustrated by the fol Pharmaceutical); In Cyte Heathes (available from Collabora lowing examples of preferred embodiments thereof, although tive Labs); Micromerol (available from Collaborative Labs); it will be understood that these examples are included merely Pefabloc SP (available from Pentapharm); Sepicontrol AS for purposes of illustration and are not intended to limit the (available from Seppic); Siegesbeckia (available from Sed Scope of the invention unless otherwise specifically indicated. erma); Sophorine (available from Barnet Products); Thio All percentages, ratios, and parts herein, in the Specification, taine (available from Barnet Products); uncaria gambis rox Examples, and Claims, are by weight and are approximations burgh extract, Zinc and mixtures thereof. unless otherwise stated. 0098 Skin Tightening Agents 0099. Also useful as active ingredients in the present Example 1 invention are skin tightening agents. 0100 Non-limiting examples of skin tightening agents Safety and Efficacy Testing on Complete Formula which are useful in the compositions of the present invention are those selected from the group consisting of Argatensyl LS 0109 Three in-house studies with small sample sizes were 9735 (available from Cognis), Biocare SA (available from conducted at Harmony Laboratories, Inc., to gather prelimi US 2010/0183528 A1 Jul. 22, 2010 nary data relating to the safety and efficacy of the Acne Treatment Powder Foundation. In addition, subjective feed TABLE 3 back regarding product aesthetics and performance was col lected. Percentage of Panelists with Visual Irritation 0110. The formulations that were tested fell within the Visual Signs of following composition: Irritation Day 1 Day 2 Day 3 O 100% 100% 100% TABLE 2 -- O% O% O% 1 O% O% O% Summary of Acne Powder Sunscreen Foundation 2 O% O% O% formulas developed and tested. 3 O% O% O% E O% O% O% Ingredient Range % wiw P O% O% O% V O% O% O% Iron Oxide, Bismuth Oxychloride & Mica blend 48.75-68.75 B O% O% O% Titanium Dioxide 8.1O-35.00 Zinc Oxide 10.00-25.65 Poly-Pore 450SA 1.OO Salicylic Acid & Allyl Methacrylates Crosspolymer ABSWhite Willow Bark Extract Powder 2.OO TABLE 4 Salix Nigra (Willow) Bark Extract Phytocide Aspen Bark Extract Powder OSO Percentage of Panelists with Sensorial Irritation Populus Tremuloides (Aspen) Bark Extract Givobio GZn 1.OO Sensorial Signs of Zinc Gluconate Irritation Day 1 Day 2 Day 3 Active Powder Purity LS9695 O.25 Exfoliance Bamboo OSO None 100% 100% 100% Bambusa Arundinacea Stem Powder Burning O% O% O% PPP-100 Pearl Powder 1.OO Itching O% O% O% Pearl Powder Stinging O% O% O% Other O% O% O%

0111. Multiple formulas were tested, but each fell within I0123. Throughout the course of this in-house study, no the ranges listed above. Representative individual formulas panelist presented with irritation nor commented on any sen are provided below in Examples 2-4. sations relating to irritation. Furthermore, the Study Coordi 0112 Irritation Study Volar Forearm nator did not observe any visual signs of irritation at any time 0113. The first study assessed irritation resulting from point during this three-day study. product use and was evaluated on the Volar forearm of study (0.124 Five Day Use Study Face participants. Ten panelists, ages 20-55, with various skin 0.125. The second small, in-house study was carried out to types and complexions were selected to participate in this determine the product’s ability to cause irritation in the form three day, baseline-controlled, randomized study. The pow of visible changes and discomfort on facial skin. In addition, der foundation was applied to the same test site for three during the final day of the study, panelists completed a ques consecutive days, allowed to remain in place for 6 hours, and tionnaire to gather Subjective feedback relating to product resulting irritation was compared to an untreated control site. aesthetics and performance. Five women, ages 20-55, with Participants completed a sensory questionnaire immediately normal to oily and oily skin types completed this baseline after and 6 hours after product application and were asked to controlled study. Each panelist was a user of loose powder comment on any adverse sensations, such as burning, itching foundation and agreed to Substitute the test productinplace of or stinging. Furthermore, participants were asked to rate the her usual foundation. Panelists had no known sensitivity to degree of the reaction, ranging from 0 (“None') to 3.0 ("Se Salicylic Acid and for the duration of the study, as well as one verely Perceptible'). In addition to gathering sensory data, week prior to the study, panelists were not allowed to use any the study coordinator checked the control and test sites at additional facial products with Salicylic Acid or Benzoyl baseline to confirm that both sites were clear. Six hours after Peroxide, nor any abrasive cleansers or scrubs. Furthermore, product application the control and test sites were graded panelists were not current users of Retin-A or any other utilizing the following grading scale and letter grades. topical acne prescription treatments. Finally, all panelists were free of any active dermatitis and had no recent sunburn Grading Scale on the facial skin. 0.126 Each morning during the study, the panelist fol 0114 0–No Reaction lowed her usual cleansing and moisturizing routine, applied 0115 +=Slight, confluent or patchy erythema the test product with an applicator brush provided, and fol 011 6 1=Mild erythema (pink) lowed with application of her usual color cosmetic products. 0117 2-Moderate erythema (definite redness) Following application, the panelist completed a questionnaire 0118 3-Strong erythema (very intense redness) to gather any sensorial data relating to irritation (i.e. burning, itching, stinging, and the like.). The loose powder foundation Letter Grades was worn for a minimum of eight hours each day and then removed with panelist's usual cleansing products. Prior to 0119 E=Edema removal, panelists completed the same sensorial question 0120 P=Papule naire to comment on any irritation experienced during the 0121 V=Vesicle day. Finally, on the fifth and final day of the study, the panel 0.122 B=Blister ists completed self-assessment questionnaires to offer Sub US 2010/0183528 A1 Jul. 22, 2010 11 jective data. Throughout the duration of the study, panelists control site were evaluated for sebum output using SEB were observed by the Study Coordinator and checked for any UTAPE(R) Skin Indicators (CuIDerm Corporation, Dallas, signs of irritation. Tex.). SEBUTAPE(R) is designed to assess sebum output and distribution of active sebaceous glands. It is made of a TABLE 5 microporous, hydrophobic film with numerous air cavities. Once the tape is applied to the skin, sebum displaces air in the Percentage of Panelists with Irritation cavities and is absorbed onto the tape. Sebum output from each follicle will form a clearly defined spot and can be Sensorial Signs assessed visually for a crude measure of follicle activity and of Irritation Day 1 Day 2 Day 3 Day 4 Day 5 sebum Volume. None 100% 100% 100% 100% 100% I0132 Panelists meeting the study criteria were checked at Burning O% O% O% O% O% baseline to ensure that the forehead area was free of any Itching O% O% O% O% O% irritation. The entire forehead was cleansed with DoveSoap Stinging O% O% O% O% O% to remove makeup, sebum, or additional debris, and the area Other O% O% O% O% O% was patted dry with gauze. Six total test sites (3 control and 3 test) were identified across the forehead using the study tem plate, composed of 6 test sites each measuring approximately TABLE 6 1.5 cm. The order of the test sites across the forehead was randomized among the panel. To the three test sites, approxi Subjective Feedback on Product Performance mately 0.02 g of product was applied using a sponge-tipped applicator and rubbed gently and evenly on the skin for 5 Comments Day 1 seconds. One control and one test site were measured with Less Blemishes, Clearer 40% SEBUTAPE(R) at 1, 3, and 6 hours post product application. Complexion The skin indicators were applied to the control and, test sites Good Coverage 80% for a total of 5 seconds and removed. Care was taken to apply Better Coverage than Current 40% Powder Foundation the same degree of pressure when sebum samples were gath Better Oil Control than Current 60% ered. Surface sebum levels of the control and test sites were Loose Powder Foundation visually assessed following the enclosed instructions and grading scale: 0127. Following five days of product use, none of the Grading Scale panelists experienced any irritation, either visual or sensorial. Sixty percent of panelists felt the product offered better oil 0.133 L=Low control compared to their current powder foundation, while 0.134 M=Medium 40% saw less blemishes or a clearer complexion during the 0135 H=High study. Eighty percent felt the powder offered good coverage, while 40% felt it offered better coverage than their usual TABLE 7 powder foundation. Additional feedback from study partici pants related to the powder's light feel, long wearability, and Percentage of Panelists with Changes in Surface Sebum Levels brightening effect on the skin. 1 Hour 3 Hours 6 Hours 0128 Study to Assess Changes in Surface Sebum Lev post product post product post product els—Forehead application application application 0129. The third, in-house study was carried out to deter mine the powder foundation's ability to control surface No Change 439* 439** 29% sebum levels on the forehead. Sebum, which is composed of Reduction 57% 579, 71.9% triglycerides, diglycerides, free fatty acids, wax esters, Increase O% O% O% squalene, cholesterol, and cholesterol esters, is produced by *100% of these panelists were classified as L. Thus, no improvement could be indicated the sebaceous glands to keep the skin and hair moisturized. It according to the grading scale, is responsible for giving the skin an oily appearance, and its **67% of these panelists were classified as L. removal is an important performance characteristic in many skin care and cosmetic products. Excess sebum, which is TABLE 8 exacerbated by high humidity conditions, can make the skin resistant to makeup application, as well as lead to comedone Percentage of Panelists with Reduction in Surface formation. Sebum Levels - Improvement by Degree of Oiliness

0130 Seven women, ages 20-55, with normal to oily and 1 Hour 3 Hours 6 Hours oily skin types completed this one-day, baseline-controlled post product post product post product study. Panelists had no known sensitivity to Salicylic Acid nor application application application were current users of products containing Salicylic Acid, Benzoyl Peroxide, or any type of prescription medications L containing retinoic acid. Such as Retin-A. Study participants M 100% 100% 75% also had to be free of any irritation on the forehead and could H 100% SO% 67% not have any recent sunburn on the forehead. For the duration of the study, bangs had to be secured away from the face and 0.136 The results show that all panelists experienced a forehead. reduction in sebum output at least at 1 time point during this 0131. In this clinical study, the test product was applied to 6-hour study. One and three hours post product application, three test sites on the forehead, and each test site had a 57% of panelists experienced an improvement in sebum out corresponding untreated, control site. At various time points put, while 71% showed improvements at the 6 hour time during this 6 hour study, one test site and its corresponding point. One hundred percent of those panelists with medium US 2010/0183528 A1 Jul. 22, 2010

and high levels of sebum showed a reduction at the one-hour time point. At the three-hour time point, those with a medium level of sebum output showed the same improvement, while 50% of those with a high level improved. Six hours post Ingredient Range % wiw product application, 75% of those with a medium level and Iron Oxide, Bismuth Oxychloride & Mica blend 48.75-60.00 67% with a high level showed a reduction in surface sebum Titanium Dioxide 8.1O-35.00 output. At the one and three-hour time points, 5 participants Zinc Oxide 10.00-25.65 were classified as having a low level of sebum output, and Poly-Pore 450SA 1.OO thus, there was no way to visually assess any improvements Salicylic Acid & Allyl Methacrylates Crosspolymer ABS White Willow Bark Extract Powder 2.OO based on the visual scale provided by Culderm. Finally, no Salix Nigra (Willow) Bark Extract participant showed a greater degree of sebum output with the Phytocide Aspen Bark Extract Powder OSO test product in place compared to the corresponding, Populus Tremuloides (Aspen) Bark Extract untreated control site. Givobio GZn 1.OO Zinc Gluconate Active Powder Purity LS9695 O.25 SUMMARY Exfoliance Bamboo OSO Bambusa Arundinacea Stem Powder 0.137 While there are a variety of loose powder founda PPP-100 Pearl Powder 1.OO tions on the market, most are promoted based solely on their Pearl Powder cosmetic attributes. Such as coverage and wearability. Addi tion of ingredients to help treat the acne condition and provide Sun protection extends this product type past that of a mere 0.141. In the Study to Assess Changes in Surface Sebum cosmetic. Acne Treatment Powder Foundation with SPF 15 Levels—Forehead, there were two shades tested in this study. combats acne by reducing & regulating sebum production, The amount of iron oxide, bismuth oxychloride, mica blend, providing gentle exfoliation, fighting P. acnes and other titanium dioxide, and Zinc oxide varied depending on the harmful microbes, soothing irritation and inflammation, and shade. The following table shows the variations in these for restoring barrier function. mulations. 0138 Clinical testing carried out on the individual raw materials selected for this product demonstrated their effec tiveness at combating various aspects contributing to the acne condition, Such as overproduction of sebum and P. acnes Ingredient Range % wiw overgrowth. Furthermore, in-house studies conducted at HLI Iron Oxide, Bismuth Oxychloride & Mica blend 54.25-68.75 preliminarily confirm that the product is non-irritating, con Titanium Dioxide 10.00-17.50 trols surface sebum levels, and provides good coverage and Zinc Oxide 15.00-22.00 Poly-Pore 450SA 1.OO long wearability. Salicylic Acid & Allyl Methacrylates Crosspolymer ABS White Willow Bark Extract Powder 2.OO Examples 2-4 Salix Nigra (Willow) Bark Extract Phytocide Aspen Bark Extract Powder OSO Representative Formulations Populus Tremuloides (Aspen) Bark Extract Givobio GZn 1.OO Powder Shades Evaluated During in-House Studies Zinc Gluconate Active Powder Purity LS9695 O.25 0.139. In the Irritation Study (Volar Forearm) described Exfoliance Bamboo OSO Bambusa Arundinacea Stem Powder above, there was one shade tested in this study. The formula PPP-100 Pearl Powder 1.OO tion is provided below. Pearl Powder

0142. While the foregoing specification teaches the prin Ingredient Range % wiw ciples of the present invention, with examples provided for Iron Oxide, Bismuth Oxychloride & Mica blend 54.25 the purpose of illustration, it will be understood that the Titanium Dioxide 17.50 practice of the invention encompasses all of the usual varia Zinc Oxide 22.OO tions, adaptations and/or modifications as come within the Poly-Pore 450SA 1.OO Scope of the following claims and their equivalents. Salicylic Acid & Allyl Methacrylates Crosspolymer ABSWhite Willow Bark Extract Powder 2.OO What is claimed is: Salix Nigra (Willow) Bark Extract 1. A dry powder foundation formulation for skin care, Phytocide Aspen Bark Extract Powder O.SO comprising: Populus Tremuloides (Aspen) Bark Extract Givobio GZn 1.OO a) a Sustained-release salicylic acid formulation, Zinc Gluconate b) one or more salicylate ions, Active Powder Purity LS9695 O.25 Exfoliance Bamboo O.SO c) Zinc oxide, and Bambusa Arundinacea Stem Powder d) titanium dioxide. PPP-100 Pearl Powder 1.OO 2. The formulation of claim 1, further comprising zinc Pearl Powder gluconate. 3. The formulation of claim 1, further comprising Active 0140 For the Five Day Use Study Face, there were three Powder Purity LS9695. shades tested in this study. The amount of iron oxide, bismuth 4. The formulation of claim 1, further comprising pearl oxychloride, mica blend, titanium dioxide, and Zinc oxide powder. varied depending on the shade. The following table shows the 5. The formulation of claim 4, wherein the pearl powder is variations in these formulations. PPP-100 pearl powder. US 2010/0183528 A1 Jul. 22, 2010

6. The formulation of claim 1, further comprising bamboo 13. The formulation of claim 1, wherein the sustained eXtract. release salicylic acid composition is selected from the group 7. The formulation of claim 1, further comprising one or consisting of Poly Pore 450 SA, MultiSalTM Salicylic Acid more pigments or colorants. 10, MultiSalTM SAL 20, MultiSalTM Salicylic Acid 30, Bio genic Salicylic Acid, and Lipo CD-SA. 8. The formulation of claim 7, wherein the pigment or 14. The formulation of claim 1, wherein the range of sali colorant comprises one or more of iron oxide, bismuth oxy cylic acid sustained release composition is 0.1-12.0%. chloride, and mica. 15. The formulation of claim 1, wherein the salicylates are 9. The formulation of claim 1, further comprising a UV present in the form of extracts of one or more of willow bark absorber. and aspen bark, and the amount of the extracts is 0.1-10.0%. 10. The formulation of claim 9, wherein the UV absorberis 16. The formulation of claim 1, further comprising one or 3-benzophenone or avobenzone. more colorants or pigments, wherein the range of said colo 11. The formulation of claim 1, wherein the salicylates are rants or pigments is 40-75%. present in an extract from willow bark or aspen bark. 17. The formulation of claim 1, further comprising one or 12. The formulation of claim 1, wherein the amount of zinc more additional anti acne agents, selected from the group oxide ranges between about 5 and about 35 weight percent. consisting of Sulfur, benzoyl peroxide, resorcinol, and resor 12. The formulation of claim 1, wherein the amount of cinol monoacetate. titanium dioxide is between about 5 and about 40 weight percent.