PRODUCT DATA SHEET Bioworld Technology,Inc.

FBXW5 polyclonal antibody

Catalog: BS72964 Host: Rabbit Reactivity: Human

BackGround: Purification&Purity: This encodes a member of the F-box family, The antibody was affinity-purified from rabbit antiserum members of which are characterized by an approximately by affinity-chromatography using epitope-specific im- 40 motif, the F-box. The F-box con- munogen and the purity is > 95% (by SDS-PAGE). stitute one of the four subunits of protein ligase Applications: complex called SCFs (SKP1-cullin-F-box), which func- WB 1:200 - 1:1000 tion in phosphorylation-dependent ubiquitination. The Storage&Stability: F-box proteins are divided into three classes: Fbws con- Store at 4°C short term. Aliquot and store at -20°C long taining WD-40 domains, Fbls containing leucine-rich re- term. Avoid freeze-thaw cycles. peats, and Fbxs containing either different protein-protein Specificity: interaction modules or no recognizable motifs. The pro- FBXW5 polyclonal antibody detects endogenous levels tein encoded by this gene contains WD-40 domains, in of FBXW5 protein. addition to an F-box motif, so it belongs to the Fbw class. DATA: Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,

50% glycerol, pH7.2 Molecular Weight: Western blot analysis of extracts of A-549 cells, using FBXW5 anti- 72kDa body. Swiss-Prot: Note: Q969U6 For research use only, not for use in diagnostic procedure.

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