PRODUCT DATA SHEET Bioworld Technology,Inc. FBXW5 polyclonal antibody Catalog: BS72964 Host: Rabbit Reactivity: Human BackGround: Purification&Purity: This gene encodes a member of the F-box protein family, The antibody was affinity-purified from rabbit antiserum members of which are characterized by an approximately by affinity-chromatography using epitope-specific im- 40 amino acid motif, the F-box. The F-box proteins con- munogen and the purity is > 95% (by SDS-PAGE). stitute one of the four subunits of ubiquitin protein ligase Applications: complex called SCFs (SKP1-cullin-F-box), which func- WB 1:200 - 1:1000 tion in phosphorylation-dependent ubiquitination. The Storage&Stability: F-box proteins are divided into three classes: Fbws con- Store at 4°C short term. Aliquot and store at -20°C long taining WD-40 domains, Fbls containing leucine-rich re- term. Avoid freeze-thaw cycles. peats, and Fbxs containing either different protein-protein Specificity: interaction modules or no recognizable motifs. The pro- FBXW5 polyclonal antibody detects endogenous levels tein encoded by this gene contains WD-40 domains, in of FBXW5 protein. addition to an F-box motif, so it belongs to the Fbw class. DATA: Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Molecular Weight: Western blot analysis of extracts of A-549 cells, using FBXW5 anti- 72kDa body. Swiss-Prot: Note: Q969U6 For research use only, not for use in diagnostic procedure. Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .