RESEARCH ARTICLE The ULK1-FBXW5-SEC23B nexus controls autophagy Yeon-Tae Jeong1,2, Daniele Simoneschi1,2, Sarah Keegan1,2,3, David Melville4, Natalia S Adler5,6, Anita Saraf7, Laurence Florens7, Michael P Washburn7,8, Claudio N Cavasotto5,6, David Fenyo¨ 1,2,3, Ana Maria Cuervo9, Mario Rossi1,5,2*, Michele Pagano1,2,10* 1Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, United States; 2Perlmutter NYU Cancer Center, NYU School of Medicine, New York, United States; 3Institute for System Genetics, NYU School of Medicine, New York, United States; 4Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States; 5Instituto de Investigacio´n en Biomedicina de Buenos Aires (IBioBA), CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina; 6Translational Medicine Research Institute (IIMT), CONICET, Facultad de Ciencias Biome´dicas and Facultad deIngenierı´a, Universidad Austral, Pilar-Derqui, Argentina; 7The Stowers Institute for Medical Research, Kansas, United States; 8Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas, United States; 9Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, United States; 10Howard Hughes Medical Institute, New York University School of Medicine, New York, United States *For correspondence: Abstract In response to nutrient deprivation, the cell mobilizes an extensive amount of
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