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Proceedings & Abstract Book 4th International Congress on Leukemia – Lymphoma – Myeloma May 22 – 25, 2013 • Istanbul, Turkey Proceedings & Abstract Book Turkish Society of Hematology Organizing Committee Congress President Teoman Soysal Istanbul University, Cerrahpasa School of Medicine, Department of Hematology, Istanbul, Turkey Congress Secretary Muzaffer Demir Trakya University, School of Medicine, Department of Hematology, Edirne, Turkey İbrahim Haznedaroğlu Hacettepe University, School of Medicine, Department of Hematology, Ankara, Turkey Scientific Chairs - Program Planners Multiple Myeloma Bart Barlogie University of Arkansas, Myeloma Institute for Research and Therapy, USA Pediatric Acute Myeloid Leukemia Ursula Creutzig AML-BFM Trial Center, University Children’s Hospital Muenster,Germany Myelodysplastic Syndromes H. Joachim Deeg Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Chronic Lymphocytic Leukemia Peter Dreger University of Heidelberg, Germany Infections Thomas J. Walsh National Cancer Institute Bethesda, USA Hodgkin Lymphoma Andreas Engert University Hospital Cologne, Cologne, Germany Acute Lymphoblastic Leukemia Nicola Gökbuget J.W. Goethe University Hospital, Frankfurt, Germany Indolent Lymphomas Robert E. Marcus King’s College Hospital, London, United Kingdom Diffuse Large B-Cell Lymphoma Christian Gisselbrecht Hôpital Saint Louis, Paris, France New Advances in Pediatric Acute Sima Jeha Lymphoblastic Leukemia St. Jude Children’s Research Hospital, Memphis, USA Aggressive Lymphomas Anna Sureda Hospital de la Santa Creu i Sant Pau, Barcelona,Spain Acute Myeloid Leukemia Martin Tallman Memorial Sloan-Kettering Cancer Center, New York , USA Chronic Myeloprolierative Disorders Ayalew Tefferi Mayo Clinic, Mayo Graduate School of Medicine, Minnesota, USA Chronic Myeloid Leukemia Nora Heisterkamp Childrens Hospital of Los Angeles, Los Angeles, USA 2 4th International Congress on Leukemia – Lymphoma – Myeloma Dear Colleagues, It gives us great pleasure to host the 4th International Congress on Leukemia-Myeloma-Lymphoma (ICLLM 2013) in Istanbul, Turkey. The 4th ICLLM Congress provides a unique forum for scientists and medical professionals gathered from around the world to meet and exchange ideas and information in the fields of hematology and oncology. The scientific program of the ICLLM Congress boasts most of the hematology masters who aim to provide a perfect balance between clinical education and news of the latest scientific developments. Istanbul as the capital of culture in Europe for 2010 started to associate with culture and the arts all over the world. Istanbul will achieve lasting gains in the fields of urban renewal, urban living and environmental and social development. Those who come to Istanbul for cultural and artistic projects will visit the city’s cultural riches, mosques, churches, palaces and museums. The cultural program also promises to be special, highlighting Istanbul’s proud culture and national heritage. Istanbul has been inhabited since the end of the 4th century B.C. Remains from the Hellenic, Roman, Byzantine and Ottoman periods are scattered throughout the city, prominent among them the Hagia Sophia, Basilica Cistern, Blue Mosque, Grand Bazaar, Topkapı Palace and Turkish Baths, making Istanbul a fascinating open air museum. You would have the opportunity to discover Turkish music, art and architecture, enjoy the delicious tastes of Turkish and Ottoman cuisine, and experience the world famous Turkish hospitality. The unique geography of Istanbul gives the opportunity to meet where the two continents meet. The Istanbul Wow Convention Center, located near the airport and easily accessible by public transport, offers excellent facilities, including all the necessary infrastructure and professionalism to successfully host a medical convention of this import. Participants from 22 countries are registered, and the Congress has been accredited by both the European Hematology Association (EHA) and the Turkish Medical Association. On behalf of the Board of the Turkish Society of Hematology and scientific faculty, I would like to welcome you to the 4th International Congress on Leukemia-Myeloma-Lymphoma. I believe that you will enjoy both the scientific and cultural aspects of the program, and that you also take advantage of the pleasure of the nice İstanbul spring. Prof. Dr. Teoman Soysal Congress President May 22 – 25, 2013 • Istanbul, Turkey 3 4th International Congress on Leukemia Lymphoma Myeloma (ICLLM) ‘Play it again, Sam’ An original misquotation of “Play it, Sam” from the 1942 film Casablanca The face of a thing is its essence or reality. On the common language, however, the face is that which looks. We, the physicians and scientists from all over the World dealing with the hematological neoplastic disorders, again have set foot upon the city of Istanbul where the continents meet. This is our fourth meeting being an essential and realistic tool for better understanding and management of leukemia, lymphoma, and plasma cell myeloma. The names of those diseases refer to the cellular neoplasia suggesting the concepts look in keeping with the demands of their own essence, their own specific characteristics. Facing the limits of knowledge in the twiligt of the complicated clinical course of leukemic disease is a common state for the physicians seeing the people of leukemia in the hospital practice. The data of randomized clinical trials, guidelines, recommendations, and expert opinions represent the current truth in this state. Developments in the basic hematology-related sciences, pathobiological experiments in the field of leukemia, and the setting of hypotheses- generating neoplastic models represent the hope for all of us. The scientific programme of this Istanbul meeting has been prepared to supply the balance between the truth and the hope for the diseases; leukemia, lymphoma, and plasma cell myeloma. The aim of this meeting is to maintain the balance between the valuable solid research data and the very valuable expert perspectives obtained with the years of scientific experience and being physicians of the patients with leukemia, lymphoma, and plasma cell myeloma. The abstracts and the educational lectures have been designated to establish an area suitable for the exchange of ideas during the meeting days. Furthermore, the manuscripts will reveal a long-term scientific source in the library of physicians dealing with the management of those hematological neoplastic disorders. Likewise, the full text content of the educational books of the meetings of International Congress on Leukemia Lymphoma Myeloma (ICLLM), including the fourth latest one, will be freely available to everybody in the website of Turkish Society of Hematology (www.thd.org.tr) just after the completion of the conference. 4 4th International Congress on Leukemia – Lymphoma – Myeloma The first thought that flashed into our minds when we first saw the completed scientific collections of the fourth International Congress on Leukemia Lymphoma Myeloma (ICLLM) was that the supreme genius of the scientists, researchers, and mentors that make possible to organize such an outstanding conference in the city of Istanbul. We hope that those days will be remembered as the days of science, friendship, and light for the physicians dealing with their patients with the diseases of leukemia, lymphoma, and plasma cell myeloma. Best regards. Prof. Dr. Muzaffer Demir Prof. Dr. Ibrahim C. Haznedaroğlu Scientific Secreteriat, Fourth International Congress on Leukemia Lymphoma Myeloma (ICLLM), Istanbul May 22 – 25, 2013 • Istanbul, Turkey 5 Contents Organizing Committee ........................................................................ 2 Scientific Program ................................................................................. 9 May 23, 2013, Thursday ................................................. 10 May 24, 2013, Thursday ................................................. 12 May 25, 2013, Thursday ................................................. 14 Proceedings ............................................................................................. 17 Acute Myeloid Leukemia ................................................ 19 Multiple Myeloma ............................................................ 41 Diffuse Large B-Cell Lymphoma ................................... 51 Chronic Myeloproliferative Disorders .......................... 69 Acute Lymphoblastic Leukemia .................................... 85 Hodgkin Lymphoma ........................................................ 95 Acute Myeloid Leukemia ................................................. 19 Multiple Myeloma ............................................................ 41 Diffuse Large B-Cell Lymphoma ................................... 51 Chronic Myeloproliferative Disorders .......................... 69 Acute Lymphoblastic Leukemia .................................... 85 Hodgkin Lymphoma ........................................................ 95 Pediatric Acute Lymphoblastic Leukemia................... 115 Infections in Hematological Malignancies ................ 155 Pediatric Acute Myeloid Leukemia ............................... 177 Myelodysplastic Syndromes .......................................... 187 Indolent Lymphomas ...................................................... 213 Chronic Myeloid Leukemia ............................................. 229 Chronic Lymphocytic Leukemia .................................... 251 Aggressive Lymphomas .................................................
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