Hindawi Journal of Oncology Volume 2019, Article ID 4536302, 6 pages https://doi.org/10.1155/2019/4536302 Review Article The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review Zulaika Roslan,1,2 Mudiana Muhamad,2 Lakshmi Selvaratnam ,3 and Sharaniza Ab-Rahim 2 Institute of Medical and Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor, Malaysia Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor, Malaysia Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar sunway, Selangor, Malaysia Correspondence should be addressed to Sharaniza Ab-Rahim; sharaniza
[email protected] Received 24 July 2018; Revised 5 February 2019; Accepted 26 February 2019; Published 26 March 2019 Academic Editor: Ozkan Kanat Copyright © 2019 Zulaika Roslan et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. Te LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in physiological events, as well as in regulating diferent mechanisms in various kinds of cancers. LRP5, LRP6, and LRP8 have been shown to play important roles in a broad panel of cancers.