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Tachibana in M, intake Shinohara Y, food Yamazaki Y, of regulator Atagi CS, important Casey an [15] E: apolipoprotein Brain al. et K, Carey KL, Barber DJ, Clegg neuronal SC, major P, Woods Tso a L, is Shen sortilin receptor [14] pro-neurotrophin The al. et D, Hartl T, Burgert MS, Nielsen G, Mastrobuoni C, Gustafsen AS, en- Carlo overexpression [13] receptor lipoprotein Low-density al. et T, West FR, Stewart PB, Verghese AJ, rate Gottesdiener the R, controlling Deane in JM, APOE Castellano for [12] role allele-dependent Novel al. et JD, Ulrich BT, Hyman J, Joung systemic C, a Chakraborty PB, in Verghese resulting WS, vivo, Chung in [11] and vitro in bodies apoptotic of clearance modulates E . McKilligin J, Reckless DJ, Grainger [10] Alzheimer onset late for risk of Triad RD. Brinton YW, Wang [9] Alzheimer in paradigm emerging an neuroenergetics: and APOE J. Valla EM, in Reiman cingulate RJ, posterior Caselli the AB, Wolf in [8] pathways metabolism energy Altered al. et L, JP, Leung Meckel D, Shonebarger B, Chavira lipid AB, Wolf mitochondria, M, contain Perkins that [7] vesicles membrane large shed Astrocytes M. Piludu T, Congiu M, hu- Piras F, mature Saba V, and Sogos progenitor of AM, Falchi characterization [6] and Purification al. et PD, Blumenthal CA, Plaza C, Caneda LE, Clarke SA, Sloan Y, Zhang [5] O AR, Scholze ML, Bennett SA, Sloan K, Chen Y, Zhang [4] by anim- ( E4 apolipoprotein as revealed of barrier, Roles Y. flluid Huang blood-cerebrospinal [3] the cross not does E Apolipoprotein SC. Woods DY, Hui L, Shen Spring Cold DG, disease. Kuhel Alzheimer M, in Liu roles [2] and biology normal receptors: E apolipoprotein and E Apolipoprotein G. Bu J, Herz DM, Holtzman [1] References work scientific present the to applicable parts journal its the all at with available comply statement they malpractice publication and ethics cation statement interest of Conflict (N Foundation Science Russian the by supported was study This Acknowledgements cross-validation accommodated [5] [4], data. data our confident type highly of cell derive specific to brain able were with we Coordination data, RNA-Seq assessments. in covariation number replications independent sufficient the to Due c. tdwt oauayaiiyaddciei optooi gn.NuoilAig 2016;39:217e1 Aging. Neurobiol aging. nonpathologic in decline and ability vocabulary with ated 1997;4:356 Dis. Neurobiol cells. lastoma tothe gene protein flluorescent green of targeting with mice in 2004;24:8872 Biol. Cell Mol mice. in function motor normal for required is and teins 2015;290:14208 Chem. Biol J pathway. protein-mediated RhoA a 2008;57:2092 betes. 2013;33:358 Neurosci. J brain. the in peptide amyloid-beta of catabolism for receptor 2012;109:15502 E USA. apolipoprotein Sci Acad Natl Proc beta-amyloidosis. of model mouse a in clearance Abeta brain-to-blood of rate the hances 2016;113:10186 USA. Sci Acad Natl Proc astrocytes. by pruning synapse of 2004;173:6366 JImmunol. mice. E-deficient inapolipoprotein state proinfllammatory 2016;8:232. Neurosci. Aging 2013;34:1007 2016;53:95 Dis. Alzheimers J carriers. 4 epsilon E apolipoprotein adult young 2013;139:221 Biol. Cell ATP. Histochem and droplets 2016;89:37 Neuron. mouse. with di昀fferences functional and transcriptional reveals astrocytes man 2014;34:11929 Neurosci. J cortex. cerebral the of cells vascular and neurons, 2011;39:924 Trans. 2012;303:R903 Physiol. Comp Integr Regul Physiol J Am mice. from CSF sampling for technique proved 2012;a0063122. Med. Perspect Harb 0.003. corresponding following of the 8.63E covariation in The results 4, manner. Table in non-specific listed a in apparently genes The aek tal. et Babenko Apoe − 6 ntehptaau ny h orsodn ausae 3.14E are: values corresponding the only, hypothalamus the In 06. xrsineeaini ieudrsca tes(upeetr al )ipcsteneighboring the impacts 1) Table (Supplementary stress social under mice in elevation expression – 17. – 32. – 8. uhr tt ocnito neet l uhr aera h journal the read have authors All interest. of conflict no state Authors : ApoE – )i h ahgnsso Alzheimer of pathogenesis the in 4) 64. – 31. ’ e昀f ,e l nRAsqecn rncitm n piigdtbs ofglia, database splicing and transcriptome An RNA-sequencing al. et S, Kee昀ffe ’ :mtcodilhpoye PEgntp n hoooa e.Front sex. chromosomal and genotype APOE haplotype, mitochondrial s: ApoE – 17. ou.JNuoc.2006;26:4985 Neurosci. J locus. p – vle:1.37E -values: 91. – – 47. ’ 106. ies:lsosfrom lessons disease: s о 14-15-00063). . 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Bhatnagar S, Ghanshani S, Luz G, Kelly ES, Hoeve [52] Brain Behav mice. male in anxiety and aggression of experience between Association DF. NP, Avgustinovich Bondar NN, Kudryavtseva [51] confllicts social by induced depression experimental of markers physiological and neurovascular Behavioral DF. aging Avgustinovich prevents NN, Kudryavtseva exercise [50] by stabilization APOE al. et W, Grabowska JE, Radell SN, Simeone HJ, Richter LC, Graham I, Soto [49] Science. mammals. in subfunctionalization of evolution slows genes duplicate 2015;32:1748 tandem Evol. of Biol Coregulation Mol JK. Pritchard expression. gene X, in Lan evolution [48] correlated show genes Neighboring LD. a Hurst AT, of Ghanbarian identification [47] cells: lung in interactions promoter enhancer- TERT the by mediates expression CTCF gene S. of Zienolddiny regulation A, Local Haugen ES. V, Lander Eldholm M, [46] Guttman PE, McDonel M, Kane J, Chen G, 2015;6:1 Transcription. Munson factors. 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[31] in behavior submissive and aggressive of study the for onmem- model contact APOE genotype sensory and A NN. stress Kudryavtseva prolonged [30] of e昀ffects The al. et AC, Gamst S, Goldman TL, DP, Patterson Salmon abilities KL, learning Lange onspatial GM, Peavy ofcorticosterone [29] e昀ffect Di昀fferential MS. Oitzl ER, Kloet de S, Dalm PJ, Lucassen the MM, on Kempes studies J, Grootendorst animal [28] performance: cognitive and interaction environment x Gene MS. Oitzl AM, Karssen Neu- J, genotype. Grootendorst APOE ER, of Kloet function de a [27] is AD in cortisol CSF Increased MA. Raskind GD, Schellenberg EC, Petrie incognitivefunc- CW, for changes Wilkinson ER, factors Peskind risk [26] of interplay the APOE:understanding and race, N. Stress, J, Sachs-Ericsson response stress J, Moxley and genotype She昀ffller APOE [25] G. Rimbach A, P, Nebel Huebbe J, mice. Dose E-deficient [24] apolipoprotein of response stress in Derangement DM. Na- Michaelson 19. E, Sehayek chromosome E, human Rosenne of S, biology Ben-Eliyahu I, and Gordon sequence [23] DNA The al. et J, Lamerdin J, Schmutz A, Terry A, Olsen LA, Gordon J, Grimwood [22] mito- Alzheimer of The role SM. and Khan TOMM40 RH, and Swerdlow APOE [21] of genetics the Understanding M. Lutz D, Burns W, Gottschalk A, Saunders S, Sundseth A, Roses [20] GRUYTER DE olwn eetdeprec fageso nml iea eeldb N-e.MlNuoil21.(pbaedo print). of ahead (Epub 2017. Neurobiol Mol RNA-Seq. by revealed as mice male in aggression of experience repeated following 2000;20:2064 Neurosci. J alterations. metabolic and behavioral in role 2013;249:63 Neuroscience. rats. female in adulthood 2002;133:83 Res. 1998;24:271 Behav. Aggress (DISC). 2015;e100227913. Biol. PLoS induction. complement and dysfunction 2016;352:1009 2014;134:2305 Cancer. J Int gene. TERT of regulation the in involved region enhancer novel 2016;539:452 Nature. splicing. and transcription promoters, lncRNA 2014;28:1550 Dev. 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