Supplementary Table 2 Complete list of differentially expressed genes in wild-type but not in phospho-mutant galectin-3 transfectants
GenBank Accession Fold Gene Number Description Symbol Change Ontology
NM_020300 Microsomal glutathione S-transferase 1 MGST1 17.65 prostaglandin metabolism
NM_005127 C-type lectin, superfamily member 2 CLECSF2 15.22 lectin
NM_002446 Mitogen-activated protein kinase
kinase kinase 10 MAP3K10 14.39 signal transduction
NM_000224 Keratin 18 KRT18 13.61 cytoskeleton organization and
biogenesis
NM_000321 Retinoblastoma 1 RB1 12.93 cell cycle checkpoint
NM_001444 Fatty acid binding protein 5 FABP5 11.66 negative control of cell
proliferation
NM_001946 Dual specificity phosphatase 6 DUSP6 11.52 protein dephosphorylation
NM_002224 Inositol 1,4,5-triphosphate receptor,
type 3 ITPR3 11.43 signal transduction
NM_007283 Lysophospholipase-like MGLL 10.94 lipid metabolism
NM_002771 Protease, serine, 3 PRSS3 10.57 proteolysis and peptidolysis
NM_004207 Solute carrier family 16, member 3 SLC16A3 10.04 transport
NM_004425 Extracellular matrix protein 1 ECM1 9.99 DNA packaging
NM_005397 Podocalyxin-like PODXL 9.35 cation transport
NM_007069 Similar to rat HREV107 HRASLS3 8.99 negative control of cell
proliferation
NM_020200 HHGP protein HHGP 8.25 purine salvage
NM_004657 Serum deprivation response SDPR 8.13 cell cycle
AF027205 Kunitz-type protease inhibitor SPINT2 8.12 cell motility
NM_002276 Keratin 19 KRT19 7.88 cytoskeleton organization and
biogenesis
NM_003687 LIM domain protein RIL 7.68 oxidative stress response
NM_016445 Pleckstrin 2 homolog PLEK2 7.40 calcium binding AK024648 cDNA: FLJ20995 fis MGC11034 7.18 ion transport
AK025273 cDNA: FLJ21620 fis EGLN3 6.75 apoptosis
NM_001458 Gamma filamin FLNC 6.70 actin binding
AF055033 Clone 24645 insulin-like growth
factor binding protein IGFBP5 6.65 signal transduction
NM_014391 Cardiac ankyrin repeat protein CARP 6.42 transcription regulation from
Pol II promoter
NM_019601 Sushi domain containing BK65A6.2 6.25 cell adhesion
NM_002769 Protease, serine, 1 PRSS1 6.20 proteolysis and peptidolysis
AK024697 cDNA: FLJ21044 fis RBIG1 6.12 cell adhesion
NM_018222 Hypothetical protein FLJ10793 PARVA 6.09 cytoskeletal anchoring
NM_003781 UDP-Gal:betaGlcNAc
beta 1,3-galactosyltransferase,
polypeptide 3 B3GALT3 6.05 protein glycosylation
NM_005504 Branched chain aminotransferase 1,
cytosolic BCAT1 6.02 amino acid metabolism
NM_004877 Glia maturation factor-gamma GMFG 5.87 protein phosphorylation
AF277292 C4orf1 ESAM 5.73 cell adhesion
Z70704 H.sapiens mRNA Data not found 5.59 cell growth and/or
maintenance
NM_005567 Lectin, galactoside-binding, soluble,
3 binding protein LGALS3BP 5.34 cellular defense response
NM_003004 Secreted and transmembrane 1 SECTM1 5.21 immune response
NM_006932 Smoothelin SMTN 5.16 cell shape and cell size
control
NM_016234 FACL5 for fatty acid coenzyme A
ligase 5 FACL5 5.14 fatty acid metabolism
AJ001348 cDNA for differentially
expressed CO16 gene HSJ001348 5.11 DNA damage response,
induction of cell arrest by p53
NM_012198 Grancalcin GCA 5.01 proteolysis and peptidolysis AF043909 Gastric mucin, partial cds MUC5AC 4.85 cell adhesion
NM_003761 Vesicle-associated membrane protein 8 VAMP8 4.84 protein complex assembly
AF282617 Vitellogenic carboxypeptidase-like
protein CPVL 4.76 proteolysis and peptidolysis
AB041269 mRNA for keratin 19, partial cds,
isolate:K19-141 LOC160313 4.72 cytoskeleton organization and
biogenesis
NM_012142 D-type cyclin-interacting protein 1 CCNDBP1 4.72 ion homeostasis
NM_016245 Retinal short-chain
dehydrogenase/reductase retSDR2 RetSDR2 4.50 nitrogen metabolism
NM_014914 KIAA1099 protein CENTG2 4.46 cell growth and/or maintenance
NM_004701 Cyclin B2 CCNB2 4.34 cell cycle control
NM_005118 Tumor necrosis factor superfamily,
member 15 TNFSF15 4.28 signal transduction
NM_014096 PRO1659 protein Data not found 4.14 lectin
AB011105 mRNA for KIAA0533 protein LAMA5 3.83 cell adhesion
NM_016059 CGI-124 protein PPIL1 3.83 immune response
NM_017661 Hypothetical protein FLJ20086 FLJ20086 3.78 transcription regulation
NM_006449 Cdc42 effector protein 3 CDC42EP3 3.74 signal transduction
NM_016142 Steroid dehydrogenase homolog HSD17B12 3.67 steroid biosynthesis
NM_002744 Protein kinase C, zeta PRKCZ 3.58 protein phosphorylation
NM_001546 Inhibitor of DNA binding 4,
dominant negative helix-loop-helix
protein ID4 3.55 transcription regulation from Pol
II promoter
AJ250475 mRNA for UCC1 protein UCC1 3.51 cell cycle
NM_006762 Lysosomal-associated multispanning
membrane protein-5 LAPTM5 3.47 vacuolar transport
AF264014 Scavenger receptor cysteine-rich
type 1 protein M160 precursor M160 3.40 integral plasma membrane
protein
NM_002770 Protease, serine, 2 PRSS2 3.37 proteolysis and peptidolysis AK001579 cDNA FLJ10717 fis ARAP3 3.29 cytoskeleton organization and biogenesis
NM_018239 Hypothetical protein FLJ10844 FLJ10751 3.26 cell adhesion
NM_016038 CGI-97 protein SBDS 3.23 leading strand elongation
NM_015910 Hypothetical protein LOC51057 3.15 signal transduction
NM_002755 Mitogen-activated protein kinase
kinase 1 MAP2K1 3.13 signal transduction
NM_001959 Eukaryotic translation elongation
factor 1 beta 2 EEF1B2 3.13 protein synthesis elongation
NM_001432 Epiregulin EREG 3.11 cell cycle
NM_001758 Cyclin D1 CCND1 3.11 cell cycle control
NM_018548 Hypothetical protein PRO2975 Data not found 3.04 signal transduction
NM_006096 Differentiation-related gene 1 NDRG1 3.04 heavy metal response
NM_000895 Leukotriene A4 hydrolase LTA4H 3.03 inflammatory response
NM_000110 Dihydropyrimidine dehydrogenase DPYD 3.03 glutamate biosynthesis
NM_002594 Proprotein convertase subtilisin/kexin
type 2 PCSK2 3.00 proteolysis and peptidolysis
NM_000090 Collagen, type III, alpha 1 COL3A1 0.03 cell adhesion
NM_005264 GDNF family receptor alpha 1 GFRA1 0.05 post-translational membrane
targeting
NM_006517 Solute carrier family 16, member 2 SLC16A2 0.05 monocarboxylic acid
transport
NM_001333 Cathepsin L2 CTSL2 0.06 proteolysis and peptidolysis
AB011167 mRNA for KIAA0595 protein KIAA0595 0.07 signal transduction
NM_032727 Internexin neuronal intermediate
filament protein, alpha INA 0.07 cytoskeleton organization and
biogenesis
NM_000071 Cystathionine-beta-synthase CBS 0.07 cysteine metabolism
K02046 Human procollagen type I
alpha-2 chain, partial exon 1
mutation C-propeptide region CG1A2 0.07 cell adhesion NM_003247 Thrombospondin 2 THBS2 0.08 cell adhesion
NM_000393 Collagen, type V, alpha 2 COL5A2 0.08 cell adhesion
NM_004086 Coagulation factor C homology COCH 0.08 cell adhesion
NM_005166 Amyloid beta precursor-like protein 1 APLP1 0.08 signal transduction
AB040930 mRNA for KIAA1497 protein LRRN1 0.09 signal transduction
NM_003056 Solute carrier family 19, member 1 SLC19A1 0.09 folate transport
NM_002133 Heme oxygenase 1 HMOX1 0.09 C21-steroid hormone
biosynthesis
NM_003637 Integrin, alpha 10 ITGA10 0.10 cell-matrix adhesion
AK025000 cDNA: FLJ21347 fis FLJ21347 0.10 oxidative stress response
AK024488 mRNA for FLJ00087 protein FLJ21438 0.10 signal transduction
NM_000474 Twist homolog TWIST1 0.10 transcription regulation
NM_002145 Homeo box B2 HOXB2 0.11 transcription regulation
NM_006583 Retinal pigment epithelium-derived
rhodopsin homolog RRH 0.11 phototransduction
NM_004598 Sparc/osteonectin, cwcv and
kazal-like domains proteoglycan SPOCK 0.11 cell adhesion
AK024251 cDNA FLJ14189 fis highly similar
to KIAA0918 protein KIAA0918 0.11 cell adhesion
NM_001430 Endothelial PAS domain protein 1 EPAS1 0.12 signal transduction
NM_005301 G protein-coupled receptor 35 GPR35 0.13 chemotaxis
NM_006169 Nicotinamide N-methyltransferase NNMT 0.13 catecholamine metabolism
NM_001845 Collagen, type IV, alpha 1 COL4A1 0.13 cell adhesion
NM_014934 KIAA0996 protein DZIP1 0.13 cell adhesion
AK021750 cDNA FLJ11688 fis, weakly
similar to ZINC-BINDING
PROTEIN A33 FSD1 0.14 cell shape and cell size
control
NM_003793 Cathepsin F CTSF 0.15 proteolysis and peptidolysis
NM_014592 Kv channel-interacting protein 1 KCNIP1 0.15 signal transduction
NM_006623 3-phosphoglycerate dehydrogenase PHGDH 0.15 serine biosynthesis
NM_005329 Hyaluronan synthase 3 HAS3 0.15 carbohydrate metabolism NM_006186 Nuclear receptor subfamily 4, group A,
member 2 NR4A2 0.15 signal transduction
NM_003469 Secretogranin II SCG2 0.15 protein secretion
NM_004390 Cathepsin H CTSH 0.15 proteolysis and peptidolysis
L25629 Human cathepsin-L-like CTSLL3 0.15 proteolysis and peptidolysis
NM_003012 Secreted frizzled-related protein 1 SFRP1 0.15 signal transduction
NM_006237 POU domain, class 4
transcription factor 1 POU4F1 0.16 transcription regulation from
Pol II promoter
NM_018018 Hypothetical protein FLJ10191 SLC38A4 0.16 amino acid transport
X55525 H.sapiens mRNA for type I collagen COL1A2 0.17 cell adhesion
NM_001831 Clusterin CLU 0.17 ligand
NM_000511 Fucosyltransferase 2 FUT2 0.18 carbohydrate metabolism
NM_003115 UDP-N-acteylglucosamine
pyrophosphorylase 1; Sperm
associated antigen 2 UAP1 0.18 UDP-N-acetylglucosamine
biosynthesis
NM_001627 Activated leucocyte cell adhesion
molecule ALCAM 0.18 cell adhesion
NM_005627 Serum/glucocorticoid regulated kinase SGK 0.19 protein phosphorylation
NM_006227 Phospholipid transfer protein PLTP 0.19 lipid metabolism
NM_014262 Hypothetical protein B LEPREL2 0.19 synaptonemal complex
formation
NM_002333 Low density lipoprotein
Receptor-related protein 3 LRP3 0.19 receptor mediated endocytosis
NM_004472 Forkhead box D1 FOXD1 0.19 transcription regulation
AK026945 cDNA: FLJ23292 fis C20orf97 0.19 protein phosphorylation
NM_002639 Protease inhibitor 5 SERPINB5 0.19 acute-phase response
NM_018992 Hypothetical protein FLJ20040 0.20 ion transport
NM_002006 Fibroblast growth factor 2 FGF2 0.20 cell cycle control
AB048791 mRNA for bHLH factor Hes4 Hes4 0.20 transcription regulation
AB007924 mRNA for KIAA0455 protein KIAA0455 0.20 signal transduction NM_012304 f-box and leucine-rich repeat protein 7 FBXL7 0.20 DNA repair
AB042555 mRNA, similar to rat myomegalin PDE4DIP 0.21 cell cycle
L25628 Human cathepsin-L-like CTSLL2 0.22 proteolysis and peptidolysis
AK026315 cDNA: FLJ22662 fis, clone HSI08080 FLJ22662 0.22 retrograde (Golgi to ER) transport
NM_006187 2'-5'oligoadenylate synthetase 3 OAS3 0.23 nucleobase, nucleoside,
nucleotide and nucleic acid
metabolism
NM_000713 Biliverdin reductase B BLVRB 0.23 mRNA capping
NM_002391 Midkine MDK 0.23 cell cycle control
AB033767 BSCv, partial cds C20orf3 0.24 cholesterol catabolism
NM_006005 Wolfram syndrome WFS1 0.24 energy pathways
NM_013957 Neuregulin 1, transcript
variant HRG-beta2 NRG1 0.24 signal transduction
NM_000935 Procollagen-lysine, 2-oxoglutarate
5-dioxygenase 2 PLOD2 0.25 protein modification
NM_005843 STAM-like protein containing SH3
and ITAM domains 2 STAM2 0.26 signal transduction
AF254086 EWS/ZSG fusion protein short isoform EWS/ZSG fusion 0.26 transcription regulation
NM_002456 Mucin 1, transmembrane MUC1 0.26 cholesterol catabolism
NM_005561 Lysosomal-associated membrane
protein 1 LAMP1 0.26 cell proliferation
NM_003246 Thrombospondin 1 THBS1 0.26 cell adhesion
NM_000512 Galactosamine-6-sulfate sulfatase GALNS 0.26 steroid metabolism
AB011539 mRNA for MEGF6, partial cds EGFL3 0.26 cell adhesion
NM_000308 Protective protein for
beta-galactosidase PPGB 0.27 proteolysis and peptidolysis
NM_006943 SRY-box 22 SOX12 0.27 transcription regulation
NM_005765 ATPase, H+ transporting, lysosomal
membrane sector associated
protein M8-9 ATP6IP2 0.27 vacuolar acidification
NM_001757 Carbonyl reductase 1 CBR1 0.27 nitrogen metabolism NM_000391 Ceroid-lipofuscinosis, neuronal 2
late infantile CLN2 0.28 proteolysis and peptidolysis
NM_002337 Low density lipoprotein-related
protein-associated protein 1 LRPAP1 0.28 vesicle transport
NM_001183 ATPase, H+ transporting
lysosomal, subunit 1 ATP6IP1 0.28 proton transport
AB033053 mRNA for KIAA1227 protein ZNF295 0.28 transcription regulation
NM_018386 Hypothetical protein FLJ11305 FLJ11305 0.28 ubiquitin-dependent protein
degradation
NM_006834 RAB32, member RAS oncogene
family RAB32 0.28 intracellular protein traffic
NM_000302 Procollagen-lysine, 2-oxoglutarate
5-dioxygenase PLOD 0.28 protein modification
AJ223352 mRNA for histone H2B HIST1H2BK 0.28 nucleosome assembly
NM_004435 endonuclease G, nuclear gene
encoding mitochondrial protein ENDOG 0.29 DNA metabolism
NM_000210 Integrin, alpha 6 ITGA6 0.29 cell-matrix adhesion
NM_001124 Adrenomedullin ADM 0.29 signal transduction
AK025329 cDNA: FLJ21676 fis DKFZP566H073 0.29 cell cycle
NM_001262 Cyclin-dependent kinase inhibitor 2C,
and translated products CDKN2C 0.30 cell cycle
NM_006769 LIM domain only 4 LMO4 0.30 transcription regulation
NM_004358 Cell division cycle 25B CDC25B 0.30 mitosis
NM_003878 Gamma-glutamyl hydrolase GGH 0.30 glutamine metabolism
NM_005149 T-box 19 TBX19 0.30 transcription regulation
NM_005907 mannosidase, alpha, class 1A
member 1 MAN1A1 0.31 carbohydrate metabolism
NM_006423 Rab acceptor 1 RABAC1 0.31 non-selective vesicle
AF064255 Very long-chain acyl-CoA
synthetase homolog 2 SLC27A5 0.31 fatty acid metabolism
NM_000521 Hexosaminidase B HEXB 0.31 carbohydrate metabolism
AB033025 mRNA for KIAA1199 protein KIAA1199 0.31 protein glycosylation NM_006024 Tax1 binding protein 1 TAX1BP1 0.32 anti-apoptosis
NM_019011 TRIAD3 protein TRIAD3 0.32 DNA repair
NM_004651 Ubiquitin specific protease 11 USP11 0.32 deubiquitination
NM_003377 Vascular endothelial growth factor B VEGFB 0.32 signal transduction
NM_006855 KDEL endoplasmic reticulum protein
retention receptor 3, transcript
variant 1 KDELR3 0.32 intracellular protein traffic
NM_000104 Cytochrome P450, subfamily I
polypeptide 1 CYP1B1 0.32 electron transport
NM_004095 Eukaryotic translation initiation factor
4E binding protein 1 EIF4EBP1 0.32 translational regulation
AF097431 GROS1-S protein, complete cds LEPRE1 0.32 synaptonemal complex
formation
AF278532 Beta-netrin, complete cds NTN4 0.33 cell adhesion
NM_000086 Ceroid-lipofuscinosis, neuronal 3,
juvenile CLN3 0.33 protein folding
NM_003129 Squalene epoxidase SQLE 0.33 ergosterol biosynthesis
NM_006079 Cbp/p300-interacting transactivator,
with Glu/Asp-rich carboxy-terminal
domain, 2 CITED2 0.33 transcription regulation from Pol
II promoter
J04474 Human branched chain alpha-keto acid
dehydrogenase, 3' end BCKDHA 0.33 protein modification