Supplementary Table 2 Complete list of differentially expressed in wild-type but not in phospho-mutant galectin-3 transfectants

GenBank Accession Fold Number Description Symbol Change Ontology

NM_020300 Microsomal glutathione S-transferase 1 MGST1 17.65 prostaglandin metabolism

NM_005127 C-type lectin, superfamily member 2 CLECSF2 15.22 lectin

NM_002446 Mitogen-activated kinase

kinase kinase 10 MAP3K10 14.39 signal transduction

NM_000224 Keratin 18 KRT18 13.61 cytoskeleton organization and

biogenesis

NM_000321 Retinoblastoma 1 RB1 12.93 cell cycle checkpoint

NM_001444 Fatty acid binding protein 5 FABP5 11.66 negative control of cell

proliferation

NM_001946 Dual specificity phosphatase 6 DUSP6 11.52 protein dephosphorylation

NM_002224 Inositol 1,4,5-triphosphate receptor,

type 3 ITPR3 11.43 signal transduction

NM_007283 Lysophospholipase-like MGLL 10.94 metabolism

NM_002771 Protease, serine, 3 PRSS3 10.57 proteolysis and peptidolysis

NM_004207 Solute carrier family 16, member 3 SLC16A3 10.04 transport

NM_004425 Extracellular matrix protein 1 ECM1 9.99 DNA packaging

NM_005397 Podocalyxin-like PODXL 9.35 cation transport

NM_007069 Similar to rat HREV107 HRASLS3 8.99 negative control of cell

proliferation

NM_020200 HHGP protein HHGP 8.25 purine salvage

NM_004657 Serum deprivation response SDPR 8.13 cell cycle

AF027205 Kunitz-type protease inhibitor SPINT2 8.12 cell motility

NM_002276 Keratin 19 KRT19 7.88 cytoskeleton organization and

biogenesis

NM_003687 LIM domain protein RIL 7.68 oxidative stress response

NM_016445 Pleckstrin 2 homolog PLEK2 7.40 calcium binding AK024648 cDNA: FLJ20995 fis MGC11034 7.18 ion transport

AK025273 cDNA: FLJ21620 fis EGLN3 6.75 apoptosis

NM_001458 Gamma filamin FLNC 6.70 actin binding

AF055033 Clone 24645 -like growth

factor binding protein IGFBP5 6.65 signal transduction

NM_014391 Cardiac ankyrin repeat protein CARP 6.42 transcription regulation from

Pol II promoter

NM_019601 Sushi domain containing BK65A6.2 6.25 cell adhesion

NM_002769 Protease, serine, 1 PRSS1 6.20 proteolysis and peptidolysis

AK024697 cDNA: FLJ21044 fis RBIG1 6.12 cell adhesion

NM_018222 Hypothetical protein FLJ10793 PARVA 6.09 cytoskeletal anchoring

NM_003781 UDP-Gal:betaGlcNAc

beta 1,3-galactosyltransferase,

polypeptide 3 B3GALT3 6.05 protein glycosylation

NM_005504 Branched chain aminotransferase 1,

cytosolic BCAT1 6.02 amino acid metabolism

NM_004877 Glia maturation factor-gamma GMFG 5.87 protein phosphorylation

AF277292 C4orf1 ESAM 5.73 cell adhesion

Z70704 H.sapiens mRNA Data not found 5.59 cell growth and/or

maintenance

NM_005567 Lectin, galactoside-binding, soluble,

3 binding protein LGALS3BP 5.34 cellular defense response

NM_003004 Secreted and transmembrane 1 SECTM1 5.21 immune response

NM_006932 Smoothelin SMTN 5.16 cell shape and cell size

control

NM_016234 FACL5 for fatty acid coenzyme A

ligase 5 FACL5 5.14 fatty acid metabolism

AJ001348 cDNA for differentially

expressed CO16 gene HSJ001348 5.11 DNA damage response,

induction of cell arrest by p53

NM_012198 Grancalcin GCA 5.01 proteolysis and peptidolysis AF043909 Gastric mucin, partial cds MUC5AC 4.85 cell adhesion

NM_003761 Vesicle-associated membrane protein 8 VAMP8 4.84 protein complex assembly

AF282617 Vitellogenic carboxypeptidase-like

protein CPVL 4.76 proteolysis and peptidolysis

AB041269 mRNA for keratin 19, partial cds,

isolate:K19-141 LOC160313 4.72 cytoskeleton organization and

biogenesis

NM_012142 D-type cyclin-interacting protein 1 CCNDBP1 4.72 ion homeostasis

NM_016245 Retinal short-chain

dehydrogenase/reductase retSDR2 RetSDR2 4.50 nitrogen metabolism

NM_014914 KIAA1099 protein CENTG2 4.46 cell growth and/or maintenance

NM_004701 Cyclin B2 CCNB2 4.34 cell cycle control

NM_005118 Tumor necrosis factor superfamily,

member 15 TNFSF15 4.28 signal transduction

NM_014096 PRO1659 protein Data not found 4.14 lectin

AB011105 mRNA for KIAA0533 protein LAMA5 3.83 cell adhesion

NM_016059 CGI-124 protein PPIL1 3.83 immune response

NM_017661 Hypothetical protein FLJ20086 FLJ20086 3.78 transcription regulation

NM_006449 Cdc42 effector protein 3 CDC42EP3 3.74 signal transduction

NM_016142 Steroid dehydrogenase homolog HSD17B12 3.67 steroid biosynthesis

NM_002744 Protein kinase C, zeta PRKCZ 3.58 protein phosphorylation

NM_001546 Inhibitor of DNA binding 4,

dominant negative helix-loop-helix

protein ID4 3.55 transcription regulation from Pol

II promoter

AJ250475 mRNA for UCC1 protein UCC1 3.51 cell cycle

NM_006762 Lysosomal-associated multispanning

membrane protein-5 LAPTM5 3.47 vacuolar transport

AF264014 Scavenger receptor cysteine-rich

type 1 protein M160 precursor M160 3.40 integral plasma membrane

protein

NM_002770 Protease, serine, 2 PRSS2 3.37 proteolysis and peptidolysis AK001579 cDNA FLJ10717 fis ARAP3 3.29 cytoskeleton organization and biogenesis

NM_018239 Hypothetical protein FLJ10844 FLJ10751 3.26 cell adhesion

NM_016038 CGI-97 protein SBDS 3.23 leading strand elongation

NM_015910 Hypothetical protein LOC51057 3.15 signal transduction

NM_002755 Mitogen-activated protein kinase

kinase 1 MAP2K1 3.13 signal transduction

NM_001959 Eukaryotic translation elongation

factor 1 beta 2 EEF1B2 3.13 protein synthesis elongation

NM_001432 EREG 3.11 cell cycle

NM_001758 Cyclin D1 CCND1 3.11 cell cycle control

NM_018548 Hypothetical protein PRO2975 Data not found 3.04 signal transduction

NM_006096 Differentiation-related gene 1 NDRG1 3.04 heavy metal response

NM_000895 Leukotriene A4 hydrolase LTA4H 3.03 inflammatory response

NM_000110 Dihydropyrimidine dehydrogenase DPYD 3.03 glutamate biosynthesis

NM_002594 Proprotein convertase subtilisin/kexin

type 2 PCSK2 3.00 proteolysis and peptidolysis

NM_000090 Collagen, type III, alpha 1 COL3A1 0.03 cell adhesion

NM_005264 GDNF family receptor alpha 1 GFRA1 0.05 post-translational membrane

targeting

NM_006517 Solute carrier family 16, member 2 SLC16A2 0.05 monocarboxylic acid

transport

NM_001333 Cathepsin L2 CTSL2 0.06 proteolysis and peptidolysis

AB011167 mRNA for KIAA0595 protein KIAA0595 0.07 signal transduction

NM_032727 Internexin neuronal intermediate

filament protein, alpha INA 0.07 cytoskeleton organization and

biogenesis

NM_000071 Cystathionine-beta-synthase CBS 0.07 cysteine metabolism

K02046 Human procollagen type I

alpha-2 chain, partial exon 1

mutation C-propeptide region CG1A2 0.07 cell adhesion NM_003247 Thrombospondin 2 THBS2 0.08 cell adhesion

NM_000393 Collagen, type V, alpha 2 COL5A2 0.08 cell adhesion

NM_004086 Coagulation factor C homology COCH 0.08 cell adhesion

NM_005166 Amyloid beta precursor-like protein 1 APLP1 0.08 signal transduction

AB040930 mRNA for KIAA1497 protein LRRN1 0.09 signal transduction

NM_003056 Solute carrier family 19, member 1 SLC19A1 0.09 folate transport

NM_002133 Heme oxygenase 1 HMOX1 0.09 C21-steroid hormone

biosynthesis

NM_003637 , alpha 10 ITGA10 0.10 cell-matrix adhesion

AK025000 cDNA: FLJ21347 fis FLJ21347 0.10 oxidative stress response

AK024488 mRNA for FLJ00087 protein FLJ21438 0.10 signal transduction

NM_000474 Twist homolog TWIST1 0.10 transcription regulation

NM_002145 Homeo box B2 HOXB2 0.11 transcription regulation

NM_006583 Retinal pigment epithelium-derived

rhodopsin homolog RRH 0.11 phototransduction

NM_004598 Sparc/osteonectin, cwcv and

kazal-like domains proteoglycan SPOCK 0.11 cell adhesion

AK024251 cDNA FLJ14189 fis highly similar

to KIAA0918 protein KIAA0918 0.11 cell adhesion

NM_001430 Endothelial PAS domain protein 1 EPAS1 0.12 signal transduction

NM_005301 G protein-coupled receptor 35 GPR35 0.13 chemotaxis

NM_006169 Nicotinamide N-methyltransferase NNMT 0.13 catecholamine metabolism

NM_001845 Collagen, type IV, alpha 1 COL4A1 0.13 cell adhesion

NM_014934 KIAA0996 protein DZIP1 0.13 cell adhesion

AK021750 cDNA FLJ11688 fis, weakly

similar to ZINC-BINDING

PROTEIN A33 FSD1 0.14 cell shape and cell size

control

NM_003793 Cathepsin F CTSF 0.15 proteolysis and peptidolysis

NM_014592 Kv channel-interacting protein 1 KCNIP1 0.15 signal transduction

NM_006623 3-phosphoglycerate dehydrogenase PHGDH 0.15 serine biosynthesis

NM_005329 Hyaluronan synthase 3 HAS3 0.15 carbohydrate metabolism NM_006186 Nuclear receptor subfamily 4, group A,

member 2 NR4A2 0.15 signal transduction

NM_003469 Secretogranin II SCG2 0.15 protein secretion

NM_004390 Cathepsin H CTSH 0.15 proteolysis and peptidolysis

L25629 Human cathepsin-L-like CTSLL3 0.15 proteolysis and peptidolysis

NM_003012 Secreted frizzled-related protein 1 SFRP1 0.15 signal transduction

NM_006237 POU domain, class 4

transcription factor 1 POU4F1 0.16 transcription regulation from

Pol II promoter

NM_018018 Hypothetical protein FLJ10191 SLC38A4 0.16 amino acid transport

X55525 H.sapiens mRNA for type I collagen COL1A2 0.17 cell adhesion

NM_001831 Clusterin CLU 0.17 ligand

NM_000511 Fucosyltransferase 2 FUT2 0.18 carbohydrate metabolism

NM_003115 UDP-N-acteylglucosamine

pyrophosphorylase 1; Sperm

associated antigen 2 UAP1 0.18 UDP-N-acetylglucosamine

biosynthesis

NM_001627 Activated leucocyte cell adhesion

molecule ALCAM 0.18 cell adhesion

NM_005627 Serum/glucocorticoid regulated kinase SGK 0.19 protein phosphorylation

NM_006227 Phospholipid transfer protein PLTP 0.19 lipid metabolism

NM_014262 Hypothetical protein B LEPREL2 0.19 synaptonemal complex

formation

NM_002333 Low density

Receptor-related protein 3 LRP3 0.19 receptor mediated endocytosis

NM_004472 Forkhead box D1 FOXD1 0.19 transcription regulation

AK026945 cDNA: FLJ23292 fis C20orf97 0.19 protein phosphorylation

NM_002639 Protease inhibitor 5 SERPINB5 0.19 acute-phase response

NM_018992 Hypothetical protein FLJ20040 0.20 ion transport

NM_002006 Fibroblast 2 FGF2 0.20 cell cycle control

AB048791 mRNA for bHLH factor Hes4 Hes4 0.20 transcription regulation

AB007924 mRNA for KIAA0455 protein KIAA0455 0.20 signal transduction NM_012304 f-box and leucine-rich repeat protein 7 FBXL7 0.20 DNA repair

AB042555 mRNA, similar to rat myomegalin PDE4DIP 0.21 cell cycle

L25628 Human cathepsin-L-like CTSLL2 0.22 proteolysis and peptidolysis

AK026315 cDNA: FLJ22662 fis, clone HSI08080 FLJ22662 0.22 retrograde (Golgi to ER) transport

NM_006187 2'-5'oligoadenylate synthetase 3 OAS3 0.23 nucleobase, nucleoside,

nucleotide and nucleic acid

metabolism

NM_000713 Biliverdin reductase B BLVRB 0.23 mRNA capping

NM_002391 MDK 0.23 cell cycle control

AB033767 BSCv, partial cds C20orf3 0.24 catabolism

NM_006005 Wolfram syndrome WFS1 0.24 energy pathways

NM_013957 1, transcript

variant HRG-beta2 NRG1 0.24 signal transduction

NM_000935 Procollagen-lysine, 2-oxoglutarate

5-dioxygenase 2 PLOD2 0.25 protein modification

NM_005843 STAM-like protein containing SH3

and ITAM domains 2 STAM2 0.26 signal transduction

AF254086 EWS/ZSG fusion protein short isoform EWS/ZSG fusion 0.26 transcription regulation

NM_002456 Mucin 1, transmembrane MUC1 0.26 cholesterol catabolism

NM_005561 Lysosomal-associated membrane

protein 1 LAMP1 0.26 cell proliferation

NM_003246 Thrombospondin 1 THBS1 0.26 cell adhesion

NM_000512 Galactosamine-6-sulfate sulfatase GALNS 0.26 steroid metabolism

AB011539 mRNA for MEGF6, partial cds EGFL3 0.26 cell adhesion

NM_000308 Protective protein for

beta-galactosidase PPGB 0.27 proteolysis and peptidolysis

NM_006943 SRY-box 22 SOX12 0.27 transcription regulation

NM_005765 ATPase, H+ transporting, lysosomal

membrane sector associated

protein M8-9 ATP6IP2 0.27 vacuolar acidification

NM_001757 Carbonyl reductase 1 CBR1 0.27 nitrogen metabolism NM_000391 Ceroid-lipofuscinosis, neuronal 2

late infantile CLN2 0.28 proteolysis and peptidolysis

NM_002337 Low density lipoprotein-related

protein-associated protein 1 LRPAP1 0.28 vesicle transport

NM_001183 ATPase, H+ transporting

lysosomal, subunit 1 ATP6IP1 0.28 proton transport

AB033053 mRNA for KIAA1227 protein ZNF295 0.28 transcription regulation

NM_018386 Hypothetical protein FLJ11305 FLJ11305 0.28 ubiquitin-dependent protein

degradation

NM_006834 RAB32, member RAS oncogene

family RAB32 0.28 intracellular protein traffic

NM_000302 Procollagen-lysine, 2-oxoglutarate

5-dioxygenase PLOD 0.28 protein modification

AJ223352 mRNA for histone H2B HIST1H2BK 0.28 nucleosome assembly

NM_004435 endonuclease G, nuclear gene

encoding mitochondrial protein ENDOG 0.29 DNA metabolism

NM_000210 Integrin, alpha 6 ITGA6 0.29 cell-matrix adhesion

NM_001124 ADM 0.29 signal transduction

AK025329 cDNA: FLJ21676 fis DKFZP566H073 0.29 cell cycle

NM_001262 Cyclin-dependent kinase inhibitor 2C,

and translated products CDKN2C 0.30 cell cycle

NM_006769 LIM domain only 4 LMO4 0.30 transcription regulation

NM_004358 Cell division cycle 25B CDC25B 0.30 mitosis

NM_003878 Gamma-glutamyl hydrolase GGH 0.30 glutamine metabolism

NM_005149 T-box 19 TBX19 0.30 transcription regulation

NM_005907 mannosidase, alpha, class 1A

member 1 MAN1A1 0.31 carbohydrate metabolism

NM_006423 Rab acceptor 1 RABAC1 0.31 non-selective vesicle

AF064255 Very long-chain acyl-CoA

synthetase homolog 2 SLC27A5 0.31 fatty acid metabolism

NM_000521 Hexosaminidase B HEXB 0.31 carbohydrate metabolism

AB033025 mRNA for KIAA1199 protein KIAA1199 0.31 protein glycosylation NM_006024 Tax1 binding protein 1 TAX1BP1 0.32 anti-apoptosis

NM_019011 TRIAD3 protein TRIAD3 0.32 DNA repair

NM_004651 Ubiquitin specific protease 11 USP11 0.32 deubiquitination

NM_003377 Vascular endothelial growth factor B VEGFB 0.32 signal transduction

NM_006855 KDEL endoplasmic reticulum protein

retention receptor 3, transcript

variant 1 KDELR3 0.32 intracellular protein traffic

NM_000104 Cytochrome P450, subfamily I

polypeptide 1 CYP1B1 0.32 electron transport

NM_004095 Eukaryotic translation initiation factor

4E binding protein 1 EIF4EBP1 0.32 translational regulation

AF097431 GROS1-S protein, complete cds LEPRE1 0.32 synaptonemal complex

formation

AF278532 Beta-netrin, complete cds NTN4 0.33 cell adhesion

NM_000086 Ceroid-lipofuscinosis, neuronal 3,

juvenile CLN3 0.33 protein folding

NM_003129 Squalene epoxidase SQLE 0.33 ergosterol biosynthesis

NM_006079 Cbp/p300-interacting transactivator,

with Glu/Asp-rich carboxy-terminal

domain, 2 CITED2 0.33 transcription regulation from Pol

II promoter

J04474 Human branched chain alpha-keto acid

dehydrogenase, 3' end BCKDHA 0.33 protein modification