Supplementary Table 2 Complete list of differentially expressed genes in wild-type but not in phospho-mutant galectin-3 transfectants GenBank Accession Fold Gene Number Description Symbol Change Ontology NM_020300 Microsomal glutathione S-transferase 1 MGST1 17.65 prostaglandin metabolism NM_005127 C-type lectin, superfamily member 2 CLECSF2 15.22 lectin NM_002446 Mitogen-activated protein kinase kinase kinase 10 MAP3K10 14.39 signal transduction NM_000224 Keratin 18 KRT18 13.61 cytoskeleton organization and biogenesis NM_000321 Retinoblastoma 1 RB1 12.93 cell cycle checkpoint NM_001444 Fatty acid binding protein 5 FABP5 11.66 negative control of cell proliferation NM_001946 Dual specificity phosphatase 6 DUSP6 11.52 protein dephosphorylation NM_002224 Inositol 1,4,5-triphosphate receptor, type 3 ITPR3 11.43 signal transduction NM_007283 Lysophospholipase-like MGLL 10.94 lipid metabolism NM_002771 Protease, serine, 3 PRSS3 10.57 proteolysis and peptidolysis NM_004207 Solute carrier family 16, member 3 SLC16A3 10.04 transport NM_004425 Extracellular matrix protein 1 ECM1 9.99 DNA packaging NM_005397 Podocalyxin-like PODXL 9.35 cation transport NM_007069 Similar to rat HREV107 HRASLS3 8.99 negative control of cell proliferation NM_020200 HHGP protein HHGP 8.25 purine salvage NM_004657 Serum deprivation response SDPR 8.13 cell cycle AF027205 Kunitz-type protease inhibitor SPINT2 8.12 cell motility NM_002276 Keratin 19 KRT19 7.88 cytoskeleton organization and biogenesis NM_003687 LIM domain protein RIL 7.68 oxidative stress response NM_016445 Pleckstrin 2 homolog PLEK2 7.40 calcium binding AK024648 cDNA: FLJ20995 fis MGC11034 7.18 ion transport AK025273 cDNA: FLJ21620 fis EGLN3 6.75 apoptosis NM_001458 Gamma filamin FLNC 6.70 actin binding AF055033 Clone 24645 insulin-like growth factor binding protein IGFBP5 6.65 signal transduction NM_014391 Cardiac ankyrin repeat protein CARP 6.42 transcription regulation from Pol II promoter NM_019601 Sushi domain containing BK65A6.2 6.25 cell adhesion NM_002769 Protease, serine, 1 PRSS1 6.20 proteolysis and peptidolysis AK024697 cDNA: FLJ21044 fis RBIG1 6.12 cell adhesion NM_018222 Hypothetical protein FLJ10793 PARVA 6.09 cytoskeletal anchoring NM_003781 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 B3GALT3 6.05 protein glycosylation NM_005504 Branched chain aminotransferase 1, cytosolic BCAT1 6.02 amino acid metabolism NM_004877 Glia maturation factor-gamma GMFG 5.87 protein phosphorylation AF277292 C4orf1 ESAM 5.73 cell adhesion Z70704 H.sapiens mRNA Data not found 5.59 cell growth and/or maintenance NM_005567 Lectin, galactoside-binding, soluble, 3 binding protein LGALS3BP 5.34 cellular defense response NM_003004 Secreted and transmembrane 1 SECTM1 5.21 immune response NM_006932 Smoothelin SMTN 5.16 cell shape and cell size control NM_016234 FACL5 for fatty acid coenzyme A ligase 5 FACL5 5.14 fatty acid metabolism AJ001348 cDNA for differentially expressed CO16 gene HSJ001348 5.11 DNA damage response, induction of cell arrest by p53 NM_012198 Grancalcin GCA 5.01 proteolysis and peptidolysis AF043909 Gastric mucin, partial cds MUC5AC 4.85 cell adhesion NM_003761 Vesicle-associated membrane protein 8 VAMP8 4.84 protein complex assembly AF282617 Vitellogenic carboxypeptidase-like protein CPVL 4.76 proteolysis and peptidolysis AB041269 mRNA for keratin 19, partial cds, isolate:K19-141 LOC160313 4.72 cytoskeleton organization and biogenesis NM_012142 D-type cyclin-interacting protein 1 CCNDBP1 4.72 ion homeostasis NM_016245 Retinal short-chain dehydrogenase/reductase retSDR2 RetSDR2 4.50 nitrogen metabolism NM_014914 KIAA1099 protein CENTG2 4.46 cell growth and/or maintenance NM_004701 Cyclin B2 CCNB2 4.34 cell cycle control NM_005118 Tumor necrosis factor superfamily, member 15 TNFSF15 4.28 signal transduction NM_014096 PRO1659 protein Data not found 4.14 lectin AB011105 mRNA for KIAA0533 protein LAMA5 3.83 cell adhesion NM_016059 CGI-124 protein PPIL1 3.83 immune response NM_017661 Hypothetical protein FLJ20086 FLJ20086 3.78 transcription regulation NM_006449 Cdc42 effector protein 3 CDC42EP3 3.74 signal transduction NM_016142 Steroid dehydrogenase homolog HSD17B12 3.67 steroid biosynthesis NM_002744 Protein kinase C, zeta PRKCZ 3.58 protein phosphorylation NM_001546 Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein ID4 3.55 transcription regulation from Pol II promoter AJ250475 mRNA for UCC1 protein UCC1 3.51 cell cycle NM_006762 Lysosomal-associated multispanning membrane protein-5 LAPTM5 3.47 vacuolar transport AF264014 Scavenger receptor cysteine-rich type 1 protein M160 precursor M160 3.40 integral plasma membrane protein NM_002770 Protease, serine, 2 PRSS2 3.37 proteolysis and peptidolysis AK001579 cDNA FLJ10717 fis ARAP3 3.29 cytoskeleton organization and biogenesis NM_018239 Hypothetical protein FLJ10844 FLJ10751 3.26 cell adhesion NM_016038 CGI-97 protein SBDS 3.23 leading strand elongation NM_015910 Hypothetical protein LOC51057 3.15 signal transduction NM_002755 Mitogen-activated protein kinase kinase 1 MAP2K1 3.13 signal transduction NM_001959 Eukaryotic translation elongation factor 1 beta 2 EEF1B2 3.13 protein synthesis elongation NM_001432 Epiregulin EREG 3.11 cell cycle NM_001758 Cyclin D1 CCND1 3.11 cell cycle control NM_018548 Hypothetical protein PRO2975 Data not found 3.04 signal transduction NM_006096 Differentiation-related gene 1 NDRG1 3.04 heavy metal response NM_000895 Leukotriene A4 hydrolase LTA4H 3.03 inflammatory response NM_000110 Dihydropyrimidine dehydrogenase DPYD 3.03 glutamate biosynthesis NM_002594 Proprotein convertase subtilisin/kexin type 2 PCSK2 3.00 proteolysis and peptidolysis NM_000090 Collagen, type III, alpha 1 COL3A1 0.03 cell adhesion NM_005264 GDNF family receptor alpha 1 GFRA1 0.05 post-translational membrane targeting NM_006517 Solute carrier family 16, member 2 SLC16A2 0.05 monocarboxylic acid transport NM_001333 Cathepsin L2 CTSL2 0.06 proteolysis and peptidolysis AB011167 mRNA for KIAA0595 protein KIAA0595 0.07 signal transduction NM_032727 Internexin neuronal intermediate filament protein, alpha INA 0.07 cytoskeleton organization and biogenesis NM_000071 Cystathionine-beta-synthase CBS 0.07 cysteine metabolism K02046 Human procollagen type I alpha-2 chain, partial exon 1 mutation C-propeptide region CG1A2 0.07 cell adhesion NM_003247 Thrombospondin 2 THBS2 0.08 cell adhesion NM_000393 Collagen, type V, alpha 2 COL5A2 0.08 cell adhesion NM_004086 Coagulation factor C homology COCH 0.08 cell adhesion NM_005166 Amyloid beta precursor-like protein 1 APLP1 0.08 signal transduction AB040930 mRNA for KIAA1497 protein LRRN1 0.09 signal transduction NM_003056 Solute carrier family 19, member 1 SLC19A1 0.09 folate transport NM_002133 Heme oxygenase 1 HMOX1 0.09 C21-steroid hormone biosynthesis NM_003637 Integrin, alpha 10 ITGA10 0.10 cell-matrix adhesion AK025000 cDNA: FLJ21347 fis FLJ21347 0.10 oxidative stress response AK024488 mRNA for FLJ00087 protein FLJ21438 0.10 signal transduction NM_000474 Twist homolog TWIST1 0.10 transcription regulation NM_002145 Homeo box B2 HOXB2 0.11 transcription regulation NM_006583 Retinal pigment epithelium-derived rhodopsin homolog RRH 0.11 phototransduction NM_004598 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan SPOCK 0.11 cell adhesion AK024251 cDNA FLJ14189 fis highly similar to KIAA0918 protein KIAA0918 0.11 cell adhesion NM_001430 Endothelial PAS domain protein 1 EPAS1 0.12 signal transduction NM_005301 G protein-coupled receptor 35 GPR35 0.13 chemotaxis NM_006169 Nicotinamide N-methyltransferase NNMT 0.13 catecholamine metabolism NM_001845 Collagen, type IV, alpha 1 COL4A1 0.13 cell adhesion NM_014934 KIAA0996 protein DZIP1 0.13 cell adhesion AK021750 cDNA FLJ11688 fis, weakly similar to ZINC-BINDING PROTEIN A33 FSD1 0.14 cell shape and cell size control NM_003793 Cathepsin F CTSF 0.15 proteolysis and peptidolysis NM_014592 Kv channel-interacting protein 1 KCNIP1 0.15 signal transduction NM_006623 3-phosphoglycerate dehydrogenase PHGDH 0.15 serine biosynthesis NM_005329 Hyaluronan synthase 3 HAS3 0.15 carbohydrate metabolism NM_006186 Nuclear receptor subfamily 4, group A, member 2 NR4A2 0.15 signal transduction NM_003469 Secretogranin II SCG2 0.15 protein secretion NM_004390 Cathepsin H CTSH 0.15 proteolysis and peptidolysis L25629 Human cathepsin-L-like CTSLL3 0.15 proteolysis and peptidolysis NM_003012 Secreted frizzled-related protein 1 SFRP1 0.15 signal transduction NM_006237 POU domain, class 4 transcription factor 1 POU4F1 0.16 transcription regulation from Pol II promoter NM_018018 Hypothetical protein FLJ10191 SLC38A4 0.16 amino acid transport X55525 H.sapiens mRNA for type I collagen COL1A2 0.17 cell adhesion NM_001831 Clusterin CLU 0.17 ligand NM_000511 Fucosyltransferase 2 FUT2 0.18 carbohydrate metabolism NM_003115 UDP-N-acteylglucosamine pyrophosphorylase 1; Sperm associated antigen 2 UAP1 0.18 UDP-N-acetylglucosamine biosynthesis NM_001627 Activated leucocyte cell adhesion molecule ALCAM 0.18 cell adhesion NM_005627 Serum/glucocorticoid regulated kinase SGK 0.19 protein phosphorylation NM_006227 Phospholipid transfer protein PLTP 0.19 lipid metabolism NM_014262 Hypothetical protein B LEPREL2 0.19 synaptonemal complex formation NM_002333 Low density lipoprotein Receptor-related protein 3 LRP3 0.19 receptor mediated endocytosis NM_004472 Forkhead box D1 FOXD1 0.19 transcription regulation AK026945 cDNA: FLJ23292 fis C20orf97 0.19 protein phosphorylation NM_002639 Protease inhibitor 5 SERPINB5 0.19 acute-phase response NM_018992 Hypothetical