Program Chair: Mats Ljungman
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The Next Generation www.ems-us.org EMS President: Catherine B. Klein Program Chair: Mats Ljungman Keynote Lecturers: Judith Campisi Jan H.J. Hoeijmakers Leroy Hood Mary-Claire King William J. Martin II Yosef Shiloh John A. Stamatoyannopoulos EMS Award Recipient: rd Susan S. Wallace 43 Annual Meeting PROGRAM Scan Me! Access the EMS Bellevue, Washington Annual Meeting website at www.ems-us.org/am2012/index.asp, or Scan this QR code with your smartphone Eastside of Seattle at the Hyatt Regency Bellevue or mobile device to access the site September 8–12, 2012 directly. The QR Code can be decoded by most camera-equipeed smarthphoes with a free downloaded QR code reader application. Sponsors of the 43rd Annual Meeting Platinum March of Dimes Foundation Grant 4-FY12-536 National Institute of Environmental Health Sciences, NIH R13 Grant 1R13ES022128-01 Gold Abbott Laboratories Illumina EMS Executive Board Janssen Pharmaceutical Companies Silver Agilent Technologies Miltenyi Biotec Amgen Inc. Molecular Toxicology, Inc. BioReliance Corporation National Institute of Environmental Health Sciences Boehringer Ingelheim Pharmaceuticals Pfizer Global Research and Development Bristol-Myers Squibb Sanofi Genetic Toxicology Association Society of Toxicology ILSI-HESI IVGT Committee WIL Research John Wiley & Sons, Inc. Litron Laboratories Bronze Environmental and Molecular Mutagenesis John J. Nicolette Editorial Office EpiGenie.com 43rd Annual Meeting PROGRAM Bellevue, Washington Eastside of Seattle at the Hyatt Regency Bellevue September 8–12, 2012 Program Chair: Mats Ljungman, PhD Abstracts printed in Environmental and Molecular Mutagenesis Volume 53, Number S1 The Environmental Mutagen Society was founded in 1969 and is incorporated under the laws of the District of Columbia. Its purpose is to encourage the study of mutagens in the human environment, particularly as they may affect public health, and to engage in and sponsor research and the dissemination of information related to mutagens. Membership is open to all interested scientists. All text and graphics are copyright © 2012 by the Environmental Mutagen Society and may not be used or duplicated without written consent from the Society. MEETING OVERVIEW 43rd Annual Meeting of the Environmental Mutagen Society MEETING OVERVIEW TABLE OF Contents Meeting Overview Meeting Overview .................................2 FridaY, SEPTEMBER 7 Leadership Officers .......................................... 5 4:00 PM–6:00 PM Grand Staircase LANDING (2ND Floor) Councilors ........................................5 REGISTRATION Past Presidents .....................................5 Headquarters Staff ..................................5 SatUrdaY, SEPTEMBER 8 Committees .......................................6 Table of Contents Table Special Interest Group Leaders .......................8 7:00 AM–6:00 PM GRAND BALLROOM FOYER Council Task Forces ................................8 REGISTRATION Events 7:00 AM–6:00 PM GREEN room (3RD floor) Committee Meetings .............................. 9 SPEAKER READY ROOM OPEN Special Interest Group Meetings ......................9 Welcome Reception and Student and 8:00 AM–12:00 Noon AUDITORIUM New Investigator Poster Session. 9 WORKSHOP 1 The EMS Bowling Challenge ........................ 9 New Developments in Genetic Toxicology Testing: The Pig-a Assay Business Meeting and Town Hall .................... 9 9:30 AM–12:00 Noon LAUREL President’s Reception .............................. 9 EMS EXECUTIVE BOARD MEETING Future Meetings ....................................9 12:00 Noon–1:00 PM Sponsored Events ................................ 10 LUNCH ON YOUR OWN General Information Welcome to the 43rd 1:00 PM–5:00 PM LARCH EMS Annual Meeting ........................... 11 EMS COUNCIL MEETING Meeting Highlights ............................... 11 1:00 PM–5:00 PM AUDITORIUM Registration Hours ............................... 11 WORKSHOP 2 Registration Materials ............................. 11 New Developments in Genetic Toxicology: Automated In Vitro Exhibit and Poster Hours .......................... 11 Micronucleus Assay Author Attended Poster Hours ..................... 11 1:00 PM–5:00 PM GRAND BALLROOM A Poster Presentations .............................. 11 WORKSHOP 3 Photography Policy Next Generation Technologies during Scientific Sessions ........................ 11 First Aid and Security ............................. 11 5:00 PM–7:00 PM EVERGREEN BALLROOM E About Safety and Security ......................... 12 WELCOME RECEPTION AND STUDENT AND NEW INVESTIGATOR POSTER SESSION Internet Access at the Annual Meeting .............. 12 Conference Site .................................. 12 7:00 PM–9:10 PM GRAND BALLROOM A Local Transportation ............................. 12 OPENING KEYNOTE SESSION Hotel Parking .................................... 12 7:00 PM–7:10 PM Meals ........................................... 12 WELCome AND Opening OF THE ANNUAL Meeting Agenda Mats Ljungman, The University of Michigan Friday .......................................... 13 7:10 PM–8:10 PM Saturday ........................................ 13 KEYNOTE LECTURE 1 Sunday. 14 Genomic Analysis of Mutations That Appear “Out of the Blue” Monday ......................................... 20 Lecturer: Mary-Claire King, University of Washington Tuesday ......................................... 26 8:10 PM–9:10 PM Wednesday ...................................... 29 KEYNOTE LECTURE 2 Exhibits ......................................... 32 The Key Role of DNA Damage on Cancer, Aging, and Longevity Lecturer: Jan H.J. Hoeijmakers, Erasmus University Maps of Hyatt Regency Bellevue ................... 34 2 www.ems-us.org Bellevue, Washington • September 8–12, 2012 MEETING OVERVIEW SUNdaY, SEPTEMBER 9 8:00 PM–10:00 PM LUCKY STRIKE LANES THE EMS BOWLING CHALLENGE 7:00 AM–5:00 PM GRAND BALLROOM FOYER REGISTRATION MEETING OVERVIEW MONDAY, SEPTEMBER 10 7:00 AM–5:00 PM GRAND BALLROOM E 7:00 AM–5:00 PM Grand Ballroom FOYER SPEAKER READY ROOM OPEN REGISTRATION 7:00 AM–8:30 AM BREAKFAST MEETINGS 7:00 AM–5:00 PM GRAND BALLROOM E Breakfast Pickup for Meetings EVERGREEN BALLROOM FOYER (Ticket Required—Breakfast Available at 6:45 AM) SPEAKER READY ROOM OPEN Applied Genetic Toxicology SIG EVERGREEN BALLROOM A 7:00 AM–8:30 AM BREAKFAST MEETINGS DNA Repair and Mutagenic Mechanisms SIG EVERGREEN BALLROOM B Breakfast Pickup for Meetings EVERGREEN BALLROOM FOYER (Ticket Required—Breakfast Available at 6:45 AM) Heritable Mutation and Disease SIG EVERGREEN BALLROOM C Epigenetics SIG EVERGREEN BALLROOM A 8:30 AM–9:30 AM GRAND BALLROOM I Molecular Epidemiology SIG EVERGREEN BALLROOM B KEYNOTE LECTURE 3 New Technologies SIG EVERGREEN BALLROOM C Cancer and Aging: Rival Demons Linked by Inflammation? Lecturer: Judith Campisi, Buck Institute for Age Research 8:30 AM–6:00 PM EVERGREEN BALLROOM E 9:45 AM–12:30 PM GRAND BALLROOM A POSTERS AND EXHIBITS OPEN SYMPOSIUM 1 Inflammation, Cancer, and Aging 8:30 AM–9:30 AM GRAND BALLROOM I KEYNOTE LECTURE 4 9:45 AM–12:30 PM GRAND BALLROOM I Epigenomics: Reading the Living Human Genome SYMPOSIUM 2 Lecturer: John Stamatoyannopoulos, University of Washington Emerging Approaches in Predictive Toxicology 9:45 AM–12:30 PM GRAND BALLROOM A 12:30 PM–1:45 PM EVERGREEN BALLROOM A SYMPOSIUM 3 EMM EDITORIAL BOARD MEETING Next Generation Environmental Epigenetics 12:30 PM–2:00 PM 9:45 AM–12:30 PM GRAND BALLROOM I LUNCH ON YOUR OWN SYMPOSIUM 4 Next Generation Risk Assessment and Regulatory Policies 12:30 PM–2:00 PM EVERGREEN BALLROOM C STUDENT AND NEW INVESTIGATOR LUNCHEON 12:30 PM–12:45 PM GRAND BALLROOM FOYER (Advance Registration Required) BOXED LUNCH PICKUP (Ticket Required—For the EMS Business Meeting and Town Hall) 2:00 PM–4:00 PM GRAND BALLROOM A PLATFORM SESSION 1 12:45 PM–2:00 PM GRAND BALLROOM I DNA Repair BUSINESS MEETING AND TOWN HALL (Boxed Lunches Available) 2:00 PM–4:00 PM GRAND BALLROOM I 2:00 PM–4:00 PM GRAND BALLROOM A PLATFORM SESSION 2 The Environment, Genes, and Public Health PLATFORM SESSION 3 Epigenetics and the DNA Damage Response 4:00 PM–6:00 PM EVERGREEN BALLROOM E 2:00 PM–4:00 PM GRAND BALLROOM I POSTERS SESSION 1 AND EXHIBITS Odd Numbered Posters Attended PLATFORM SESSION 4 Genotoxicity and Toxicogenomic Analyses of Environmental 6:00 PM–7:00 PM COMMITTEE MEETINGS Contaminants 2013 Program Committee (First Meeting) Larch 4:00 PM–6:00 PM EVERGREEN BALLROOM E Awards and Honors Committee JUNIPER POSTERS SESSION 2 AND EXHIBITS Public Relations and Communications Committee Madrona Even Numbered Posters Attended Publication Policy Committee LAUREL 6:00 PM–8:00 PM DINNER ON YOUR OWN www.ems-us.org 3 MEETING OVERVIEW 43rd Annual Meeting of the Environmental Mutagen Society MEETING OVERVIEW 6:00 PM–7:00 PM COMMITTEE MEETINGS 2:00 PM–4:00 PM GRAND BALLROOM I Alexander Hollaender Outreach Committee JUNIPER PLATFORM SESSION 6 Chromosome Instability Education, Student and New Investigator Affairs Committee Larch Membership and Professional Development Committee LAUREL 4:15 PM–5:15 PM GRAND BALLROOM I KEYNOTE LECTURE 6 7:00 PM–8:00 PM The Emergence of Proactive P4 Medicine: A Revolution in Special Interest Group Leaders LAUREL Healthcare Lecturer: Leroy Hood, Institute for Systems Biology 8:00 PM–10:30 PM BELLEVUE ARTS MUSEUM PRESIDENT’S RECEPTION 5:15 PM–6:15 PM GRAND BALLROOM I (Open to All Meeting Registrants) EMS AWARD LECTURE Oxidative DNA Damages: Search and Destroy Lecturer: Susan S. Wallace, University of Vermont TUesdaY, SEPTEMBER 11 7:00 PM–12:00 Midnight Grand Ballroom E 7:00 AM–5:00 PM