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United States Patent 19 11 Patent Number: 5,418,243 Angerbauer Et Al
USOO5418243A United States Patent 19 11 Patent Number: 5,418,243 Angerbauer et al. 45 Date of Patent: May 23, 1995 54 SUBSTITUTED 4-PHENYL-PYRIDONES 4,215,126 7/1980. Durant et al........................ 514/345 AND 4-PHENYL-3-ALKOXYPYRIDNES 4,684,477 8/1987 Sugimori et al. ... 546/290 4,916,239 4/1990 Treiber ................. ... 549/292 75 Inventors: Rolf Angerbauer; Peter Fey; Walter 4,988,711 1/1991 Angerbauer et al. ... 514/326 Hibsch, all of Wuppertal; Thomas 5,032,602 7/1991 Fey et al. ................. ... 54/345 Philipps, Cologne; Hilmar Bischoff, 5,064,841 11/1991 Angerbauer et al. ... 514/336 Wuppertal; Hans-Peter Krause, 5,138,090 8/1992 Fey et al. .............................. 560/59 Schwelm; Jörg Peterson-von Gehr, Bochum; Delf Schmidt, Wuppertal, FOREIGN PATENT DOCUMENTS all of Germany 0373423 6/1990 European Pat. Off. 73 Assignee: Bayer Aktiengesellschaft, OTHER PUBLICATIONS Leverkusen, Germany J. Med. Chem., 1990, vol. 33, pp. 52-60; “Synthesis and 21) Appl. No.: 166,775 Biological Activity of New HGM-CoA Reductase 22 Filed: Dec. 14, 1993 Inhibitors ... ', G. Beck. Primary Examiner-C. Warren Ivy (30) Foreign Application Priority Data Assistant Examiner-A. A. Owens Dec. 21, 1992 DE Germany ........................ 4243 278.2 Attorney, Agent, or Firm-Sprung, Horn, Kramer & Jun. 28, 1993 DE Germany ........................ 43 21421.5 Woods 511 Int. Cl...................... A61K 31/44; C07D 213/64 57 ABSTRACT 52 U.S. C. ...................................... 514/345; 546/24; 546/290; 514/89 Substituted 4-phenyl-pyridones and 4-phenyl-2-alkox 58 Field of Search .................. 546/290, 24; 514/345, ypyridines are prepared by reducing corresponding 514/89 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine de rivatives. -
Production of Malonic Acid Through the Fermentation of Glucose
University of Pennsylvania ScholarlyCommons Department of Chemical & Biomolecular Senior Design Reports (CBE) Engineering 4-20-2018 Production of Malonic Acid through the Fermentation of Glucose Emily P. Peters University of Pennsylvania, [email protected] Gabrielle J. Schlakman University of Pennsylvania, [email protected] Elise N. Yang University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/cbe_sdr Part of the Biochemical and Biomolecular Engineering Commons Peters, Emily P.; Schlakman, Gabrielle J.; and Yang, Elise N., "Production of Malonic Acid through the Fermentation of Glucose" (2018). Senior Design Reports (CBE). 107. https://repository.upenn.edu/cbe_sdr/107 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/cbe_sdr/107 For more information, please contact [email protected]. Production of Malonic Acid through the Fermentation of Glucose Abstract The overall process to produce malonic acid has not drastically changed in the past 50 years. The current process is damaging to the environment and costly, requiring high market prices. Lygos, Inc., a lab in Berkeley, California, has published a patent describing a way to produce malonic acid through the biological fermentation of genetically modified easty cells. This proposed technology is appealing as it is both better for the environment and economically friendly. For the process discussed in this report, genetically modified Pichia Kudriavzevii yeast cells will be purchased from the Lygos lab along with the negotiation of exclusive licensing rights to the technology. The cells will be grown in fermentation vessels, while being constantly fed oxygen, glucose and fermentation media. The cells will excrete malonic acid in the 101 hour fermentation process. -
Preparation of Amine Alanes
Europaisches Patentamt J European Patent Office 00 Publication number: 0 273 229 Office europeen des brevets A2 EUROPEAN PATENT APPLICATION © Application number: 87117901.6 © mt. ci.<: C01B 6/06 , C07C 87/00 © Date of filing: 03.12.87 © Priority: 22.12.86 US 945286 © Applicant: ETHYL CORPORATION Ethyl Tower 451 Florida Boulevard ® Date of publication of application: Baton Rouge Louisiana 70801 (US) 06.07.88 Bulletin 88/27 @ Inventor: Marlett, Everett Michael ® Designated Contracting States: 9355 Greenbriar Drive AT BE CH DE ES FR GB IT LI LU NL SE Baton Rouge Louisiana 7081 5(US) 0 Representative: Sandmair, Kurt, Dr. Patentanwalte Schwabe, Sandmair, Marx Stuntzstrasse 16 D-8000 MUnchen 80(DE) © Preparation of amine alanes. © Process for the preparation of an amine alane, said process comprising reacting: (a) an alkali metal aluminum tetrahydride having the formula MAIH4, wherein M is an alkali metal selected from the class consisting of lithium, sodium and potassium, (b) a hydrogen halide, and (c) a complexing tertiary amine. In this process, NaAlhU, HCI, and (C2H5)3N are preferred reactants. CM CM a. LU Xerox Copy Centre 0 273 229 PREPARATION OF AM1NE ALANES The invention pertains to the formation of amine alanes AIH3«NR3. These materials are useful as chemical intermediates. For example, they can be reacted with a silicon halide such as SiCU or SiF4 to produce silane. Reference is made to U.S. 4,474,743. It pertains to production of silane and aluminum fluoride from silicon tetrafluoride and amine alanes. Reference is also made to U.S. 4,006,095. It teaches, inter alia, that SiCU reacts with a toluene solution of AIH3 containing dimethyl ether or a stabilizing amine. -
WO 2013/089962 Al 20 June 2013 (20.06.2013) W P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/089962 Al 20 June 2013 (20.06.2013) W P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every B01J 31/04 (2006.01) B01J 31/18 (2006.01) kind of national protection available): AE, AG, AL, AM, B01J 31/14 (2006.01) B01J 31/22 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) Number: International Application DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 12/065285 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 15 November 2012 (15.1 1.2012) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 13/323,328 12 December 201 1 (12. 12.201 1) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): CHEV¬ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, RON PHILLIPS CHEMICAL COMPANY LP UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, [US/US]; 10001 Six Pines Drive, The Woodlands, Texas TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 77380 (US). -
PESTICIDES Criteria for a Recommended Standard
CRITERIA FOR A RECOMMENDED STANDARD OCCUPATIONAL EXPOSURE DURING THE MANUFACTURE AND FORMULATION OF PESTICIDES criteria for a recommended standard... OCCUPATIONAL EXPOSURE DURING THE MANUFACTURE AND FORMULATION OF PESTICIDES * U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service Center for Disease Control National Institute for Occupational Safety and Health July 1978 For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 DISCLAIMER Mention of company names or products does not constitute endorsement by the National Institute for Occupational Safety and Health. DHEW (NIOSH) Publication No. 78-174 PREFACE The Occupational Safety and Health Act of 1970 emphasizes the need for standards to protect the health and provide for the safety of workers occupationally exposed to an ever-increasing number of potential hazards. The National Institute for Occupational Safety and Health (NIOSH) has implemented a formal system of research, with priorities determined on the basis of specified indices, to provide relevant data from which valid criteria for effective standards can be derived. Recommended standards for occupational exposure, which are the result of this work, are based on the effects of exposure on health. The Secretary of Labor will weigh these recommendations along with other considerations, such as feasibility and means of implementation, in developing regulatory standards. Successive reports will be presented as research and epideiriologic studies are completed and as sampling and analytical methods are developed. Criteria and standards will be reviewed periodically to ensure continuing protection of workers. The contributions to this document on pesticide manufacturing and formulating industries by NIOSH staff members, the review consultants, the reviewer selected by the American Conference of Governmental Industrial Hygienists (ACGIH), other Federal agencies, and by Robert B. -
Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, Elucidation of Regiochemistry, And
Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, Elucidation of Regiochemistry, and Description of Conformational Isomerism by NMR Spectroscopy and Computation Joseph Shelby Clements II Dissertation submitted to the faculty of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy In Chemistry Paul R. Carlier, Chair David G. I. Kingston James M. Tanko Gordon T. Yee May 2, 2017 Blacksburg, VA Keywords: Hydrazine, acylation, α-effect, regioselectivity, hydrazide, voltage- gated, (E)-/(Z)-, 19F NMR, single electron transfer (SET), rotational barrier, N-N bond rotation, rotational isomerism, helicity, transition state, dihedral angle Copyright 2017, Joseph S. Clements II Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, Elucidation of Regiochemistry, and Description of Conformational Isomerism by NMR Spectroscopy and Computation Joseph Shelby Clements II ABSTRACT Based on the success of diacyl-tert-butylhydrazines RH-5849 and RH-1266 in controlling agricultural crop pests, we endeavored to synthesize our own diacylbenzyl- and arylhydrazine derivatives for use against the malaria vector Anopheles gambiae. In the process of producing a library of compounds for assay against An. gambiae, it became clear that employing regioselective acylation techniques (in molecules that feature two nucleophilic, acyclic nitrogen atoms α to one another) would be imperative. Synthesis of the library derivatives proceeded rapidly and after topical assay, we found three compounds that were more toxic than the RH- series leads. One of the three displayed an LD50 value of half that of RH-1266, though patch clamp assay concluded that toxicity was not necessarily linked to inhibition of mosquito K+ channel Kv2.1. -
Synthesis of Novel Extremely Sterically Hindered Tertiary Alkylamines
Synthesis of Novel Extremely Sterically Hindered Tertiary Alkylamines von der Fakultät für Naturwissenschaften der Technischen Universität Chemnitz genehmigte Dissertation zur Erlangung des akademischen Grades doktor rerum naturalium (Dr. rer. nat.) vorgelegt von M.Sc. Tharallah A. Shoker geboren am 18. April 1985 in Nabi Chit, Lebanon eingereicht am 17. January 2018 Gutachter: Prof. Dr. Klaus Banert JP Dr. Evgeny Kataev Tag der Verteidigung: 16. April 2018 Die vorliegende Arbeit wurde in der Zeit von Oktober 2015 bis Oktober 2017 am Institut für Chemie an der Fakultät für Naturwissenschaften der Technischen Universität Chemnitz unter der Leitung von Prof. Dr. Klaus Banert angefertigt. 2 Bibliographic Description Synthesis of Novel Extremely Sterically Hindered Tertiary Alkylamines SHOKER, THARALLAH Technische Universität Chemnitz, Fakultät für Naturwissenschaften Dissertation, 2017, 208 pages. Abstract Three advanced methodologies for the preparation of extremely sterically hindered tertiary alkyl amines have been developed. The syntheses of 28 novel tertiary alkylamines that accommodate unusual steric hindrance are detailed. The electrophilic amination of alkyl Grignard reagents with N-chlorodialkylamines, in the presence of N,N,N′,N′-tetramethylethylenediamine (TMEDA) as a key additive, gives a variety of unprecedentedly sterically hindered tertiary alkylamines in good yields. Alternative strategy to 1-adamantyl-substituted (1-Ad) sterically hindered tertiary amines, which involved instead an SN1 reaction between 1-Ad cation with various secondary amines, is described. A complementary strategy to 1-Ad-based sterically hindered tertiary amines, which involves an iminium salt intermediate, is also reported. Salient features of the three protocols that are detailed here include unusual tolerance of steric hindrance, mild reaction conditions employed, ease of product isolation-purification, and absence of catalysts/transition metals. -
The Synthesis and Characterization of Energetic Materials from Sodium Azide
THE SYNTHESIS AND CHARACTERIZATION OF ENERGETIC MATERIALS FROM SODIUM AZIDE A Thesis Presented to The Academic Faculty By Joshua Aronson In Partial Fulfillment Of the Requirements for the Degree Doctor of Philosophy in the School of Chemistry and Biochemistry Georgia Institute of Technology October 2004 THE SYNTHESIS AND CHARACTERIZATION OF ENERGETIC MATERIALS FROM SODIUM AZIDE Approved by: Charles L. Liotta, Advisor Kent Richman Charles A. Eckert Julia Kubanek David Collard November 17, 2004 ii This thesis is dedicated to M. G. iii ACKNOWLEDGEMENT I would first like to thank Dr. Liotta and Dr. Eckert for their support and encouragement. I will forever envy your enthusiasm and spirit. I would also like to extend my appreciation to everyone at American Pacific. My experiences in Utah and Las Vegas contributed a great deal to my graduate education. In addition, I want to thank the entire Liotta-Eckert research group—especially Kris and Pamela. The two of you made all of this not only bearable, but fun. Finally, I would like to thank my mom and Mary Katherine for their support. I would not have made it without you. iv TABLE OF CONTENTS Acknowledgement iv List of Figures viii List of Tables xii List of Abbreviations xiii Summary xv Chapter I Introduction 1 Chapter II A Novel Approach To The Synthesis Of Tetrazoles 5 Introduction 5 Experimental Methods 10 Materials 10 Apparatus 10 Procedures 11 Results and Discussion 14 Conclusion 37 References 38 Chapter III The Synthesis and Characterization Of Glycidyl 40 Azide Polymer Introduction 40 Experimental -
Beryllium Chloride Apparatus. Figure M
Durham E-Theses Organic and hydride chemistry of beryllium Bell, N.A How to cite: Bell, N.A (1964) Organic and hydride chemistry of beryllium, Durham theses, Durham University. Available at Durham E-Theses Online: http://etheses.dur.ac.uk/8894/ Use policy The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in Durham E-Theses • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full Durham E-Theses policy for further details. Academic Support Oce, Durham University, University Oce, Old Elvet, Durham DH1 3HP e-mail: [email protected] Tel: +44 0191 334 6107 http://etheses.dur.ac.uk ORGANIC AND HYDRIDE CHEMISTRY OF BERYLLIUM oy N.A. BELL. A thesis.submitted for the Degree of Doctor of Philosophy in the University- of Durham. June 196^-. I Acknowledgements. The author wishes to express his sincere thanks to Professor G-.E. Coates, M.A., D.Sc., F.R.I.C., under whose direction this research was carried out, for his constant encouragement and extremely valuable advice. ' The author is also indebted to the Department of Scien• tific and Industrial Research for a Research StudiSntshrp. I I Memorandum. The work described in this thesis was carried out in the University of Durham between September 19b1 and May 196A-. -
WO 2017/061959 Al 13 April 2017 (13.04.2017) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/061959 Al 13 April 2017 (13.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A01P 7/00 (2006.01) A01N 25/28 (2006.01) kind of national protection available): AE, AG, AL, AM, A01P 7/02 (2006.01) A01N 25/04 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A01P 7/04 (2006.01) A01N 43/90 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A01P 5/00 (2006.01) A01N 53/06 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, PCT/TR2015/000350 MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (22) International Filing Date: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 2 December 2015 (02.12.2015) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 2014/14665 4 December 2014 (04. -
2,4-Dichlorophenoxyacetic Acid Analysis of Risk to Endangered And
2,4-Dichlorophenoxyacetic Acid Analysis of Risks to Endangered and Threatened Salmon and Steelhead December 1, 2004 Shannon Borges Cara Dzubow Greg Orrick Ann Stavola Environmental Field Branch Office of Pesticide Programs Summary 2,4-D is a widely used herbicide applied to many crop sites and non-crop sites in the Pacific Northwest. Acid and amine salt forms of 2,4-D are "practically non-toxic" to “slightly toxic,” while ester forms of 2,4-D are “slightly toxic” to “highly toxic” to fish. Some forms of 2,4-D may lead to adverse acute and chronic effects. Some esters are “moderately toxic” to freshwater invertebrates, which may be sources of food for salmonids. All forms of 2,4-D that were tested had relatively high toxicity to vascular plants, which could lead to loss of cover for salmonid adults and young. Terrestrial uses of 2,4-D in the Pacific Northwest pose no direct or indirect risk to fish. 2,4-D acid and amine salts pose an indirect risk to fish when used on rice crops and for aquatic weed control. 2,4-D esters pose acute and chronic risk directly and indirectly when used for aquatic weed control. This endangered species risk assessment is developed for Federally listed Pacific salmon and steelhead. The findings of the Office of Pesticide Program’s Environmental Risk Assessment developed for non-target fish and wildlife as part of the reregistration process are applied to determine the potential risks to the 26 listed threatened and endangered Evolutionarily Significant Units (ESUs) of Pacific salmon and steelhead. -
Sodium Aluminum Hydride
Sodium aluminum hydride sc-251007 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Sodium aluminum hydride STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY3 HEALTH3 HAZARD INSTABILITY1 W SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY: ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS Al-H4.Na, "aluminate (1-), tetrahydro-, sodium", "aluminum sodium hydride", "sodium aluminium tetrahydride", "sodium tetrahydroaluminate (1-)" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 3 Toxicity: 2 Body Contact: 3 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 7 EMERGENCY OVERVIEW RISK Contact with water liberates extremely flammable gases. Harmful if swallowed. Causes burns. Risk of serious damage to eyes. Highly flammable. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. ! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. EYE ! The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. ! If applied to the eyes, this material causes severe eye damage. SKIN ! The material can produce chemical burns following direct contactwith the skin.