(PON) on 01/12/2018
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
United States Patent 19 11 Patent Number: 5,418,243 Angerbauer Et Al
USOO5418243A United States Patent 19 11 Patent Number: 5,418,243 Angerbauer et al. 45 Date of Patent: May 23, 1995 54 SUBSTITUTED 4-PHENYL-PYRIDONES 4,215,126 7/1980. Durant et al........................ 514/345 AND 4-PHENYL-3-ALKOXYPYRIDNES 4,684,477 8/1987 Sugimori et al. ... 546/290 4,916,239 4/1990 Treiber ................. ... 549/292 75 Inventors: Rolf Angerbauer; Peter Fey; Walter 4,988,711 1/1991 Angerbauer et al. ... 514/326 Hibsch, all of Wuppertal; Thomas 5,032,602 7/1991 Fey et al. ................. ... 54/345 Philipps, Cologne; Hilmar Bischoff, 5,064,841 11/1991 Angerbauer et al. ... 514/336 Wuppertal; Hans-Peter Krause, 5,138,090 8/1992 Fey et al. .............................. 560/59 Schwelm; Jörg Peterson-von Gehr, Bochum; Delf Schmidt, Wuppertal, FOREIGN PATENT DOCUMENTS all of Germany 0373423 6/1990 European Pat. Off. 73 Assignee: Bayer Aktiengesellschaft, OTHER PUBLICATIONS Leverkusen, Germany J. Med. Chem., 1990, vol. 33, pp. 52-60; “Synthesis and 21) Appl. No.: 166,775 Biological Activity of New HGM-CoA Reductase 22 Filed: Dec. 14, 1993 Inhibitors ... ', G. Beck. Primary Examiner-C. Warren Ivy (30) Foreign Application Priority Data Assistant Examiner-A. A. Owens Dec. 21, 1992 DE Germany ........................ 4243 278.2 Attorney, Agent, or Firm-Sprung, Horn, Kramer & Jun. 28, 1993 DE Germany ........................ 43 21421.5 Woods 511 Int. Cl...................... A61K 31/44; C07D 213/64 57 ABSTRACT 52 U.S. C. ...................................... 514/345; 546/24; 546/290; 514/89 Substituted 4-phenyl-pyridones and 4-phenyl-2-alkox 58 Field of Search .................. 546/290, 24; 514/345, ypyridines are prepared by reducing corresponding 514/89 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine de rivatives. -
Rhode Island Hazardous Substance List
Rhode Island Hazardous Substance List Source: T - ACGIH F - NFPA49 C - IARC Alphabetical Order C.A.S. ACGIH NFPA IARC CHEMICAL NAME 13010-47-4 C 1,-(2-Chloroethyl)-3-cyclohexyl-1-Nitrosourea 76-11-9 T 1,1,1,2-tetrachloro-2,2-difluoroethane 76-12-0 T 1,1,2,2-tetrachloro-1,2-difluoroethane 79-34-5 T 1,1,2,2-tetrachloroethane - skin 76-13-1 T 1,1,2-trichloro-1,2,2-trifluoroethane 79-00-5 T F C 1,1,2-trichloroethane - skin 594-72-9 T 1,1-Dichloro-1-nitroethane 74-34-3 T 1,1-dichloroethane 57-14-7 T 1,1-dimethylhydrazine (udmh) 96-18-4 T 1,2,3-trichloropropane 120-82-1 T 1,2,4-Trichlorobenzene 106-88-7 F 1,2-Butylene oxide 107-15-3 T F 1,2-Diaminoethane 96-12-8 C 1,2-Dibromo-3-chloropropane 106-93-4 T F C 1,2-Dibromoethane - skin 107-06-2 T F 1,2-Dichlorethane 540-59-0 T F 1,2-Dichloroethene 540-59-0 T F 1,2-Dichloroetylene 1615-80-1 C 1,2-Diethylhydrazine C 1,2-Dimethyl hydrazine - skin 106-99-0 T F 1,3-Butadiene 118-52-5 T 1,3-Dichloro-5,5-dimethylhydantoin 542-75-6 T F 1,3-Dichloropropene (cis and trans) 542-75-6 T F 1,3-Dichloropropylene 110-56-5 F 1,4-Dichlorobutane 123-91-1 T F C 1,4-Dioxane 1120-71-4 1-3-Propane sultone 110-53-2 F 1-Bromopentane 106-89-8 T F C 1-Chloro,2,3-epoxy-propane 600-25-9 T 1-Chloro-1-nitropropane 97-00-7 F 1-chloro-2,4-dinitrobenzene 543-59-9 F 1-Chloropentane 112-30-1 F 1-Decanol 111-27-3 F 1-Hexanol 141-79-7 T F 1-Isobutenyl methyl ketone 108-03-2 T F 1-Nitropropane 71-41-0 F 1-Pentanol 110-58-7 F 1-Pentylamine 111-40-0 T F 2,2'-Diaminodiethylamine 111-44-4 F 2,2'Dichlorodiethyl ether 75-99-0 T 2,2-dichloropropionic acid 556-52-5 T 2,3-Epoxy-1-propanol 93-76-5 T 2,4,5-T 95-95-4 F 2,4,5-trichlorophenol 88-06-2 F C 2,4,6-trichlorophenol 118-96-7 T F 2,4,6-Trinitro Toluene 479-95-8 T 2,4,6-Trinitrophenyl-methylnitramine 94-75-7 T 2,4-d (2,4-dichlorophenoxyacetic acid) 97-02-9 F 2,4-dinitroaniline 584-84-9 T F 2,4-Tolylene diisocyanate 108-83-8 T 2,6-Dimethyl-4-heptanone 108-83-8 T 2,6-Dimethyl-4-heptanone 128-37-0 T 2,6-Ditert. -
Indiana State University ISU Laboratory Safety Guideline
ISU Laboratory Safety Guideline Working with Organic Peroxides and Storage Guidelines Date: December 2012 Indiana State University Organic peroxide is a compound containing the -O-O- structure and is considered a structural derivative of hydrogen peroxide. Organic peroxides are one of the most hazardous materials handled in the laboratory. These peroxides are low powered explosives that are sensitive to shock, sparks or other accidental ignition due to the weak –O-O bond. Organic compounds such as ethers can react with oxygen to form unstable peroxides. Peroxide formation can also occur under normal storage conditions when compounds become concentrated by evaporation or when mixed with other compounds. Types of Compounds known to form peroxides : Ethers containing primary and secondary alkyl groups (never distill an ether before it has been shown to be free of peroxide) Compounds containing benzylic hydrogens Compounds containing allylic hydrogens (C=C-CH) Compounds containing a tertiary C-H group (e.g., decalin and 2,5-dimethlyhexane) Compounds containing conjugated, polyunsaturated alkenes and alkynes (e.g., 1,3-butadiene, vinyl acetylene) Compounds containing secondary or tertiary C-H groups adjacent to an amide (e.g., 1-methyl-2- pyrrolidinone Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards, Updated Version General Procedures for working with Peroxide-forming chemicals: • Be aware of the use of peroxide-forming chemicals when designing or conducting a new experiment. • If possible, purchase material containing an inhibitor such as butylated hydroxytoluene (BHT). • Date the container when received, opened and tested. • Consult Prudent Practices or other resources for storage shelf-life and testing procedures. -
Peroxide-Forming Chemicals
Peroxide-Forming Chemicals 4 Ways to stop explosions, injuries, and added expenses: 1) Track shelf life A) label when tested and when to retest B) date when received 2) Handle with proper personal protective equipment A) gloves B) googles/safety glasses C) flame-resistant lab coat D) training E) Ask [the Dept. of Chemistry and Dept. of Environmental Health & Safety] for help 3) Store properly A) flammable storage cabinet if applicable B) avoid i) heat (keep in a cool place) ii) impact iii) friction iv) light (keep in a dark place) 4) Buy the right amount A) based on what will be used B) reduce the disposal of any un-used material (Dubiel). The Department of Chemistry wants you to learn from our experiences. Amides, Dioxane, Ethers, secondary alcohols, and Tetrahydrofuran (as well as other cyclic ethers) must be checked for peroxides. The University of Pittsburgh Department of Environmental Health and Safety (EH&S) recommends that all peroxide-forming chemicals should be tested every six months for peroxide content, and any chemicals that test positive should either be purified before use to remove the peroxide or discarded as chemical waste and replaced with fresh material. (http://www.ehs.pitt.edu/assets/docs/peroxide-forming.pdf). Ken Migliorese, a previous staff member, emailed the Department of Chemistry to remind us of the importance of doing peroxide testing on a regular basis. The need to test for peroxides was made clear to us by a series of unfortunate explosions which occurred in the undergraduate organic teaching labs in 2008. We had multiple defective layers of protection that caused failures of safety measures and three catastrophic errors (Reason). -
Peroxide Forming Chemicals
What are organic peroxides? Organic peroxides are a class of compounds that have unusual stability problems that make them among the most hazardous substances found in the laboratory. The lack of stability is due to the presence of an oxidation and reduction center within the same molecule. R-O-O-R R = organic side chains O-O = Peroxo bridge As a class, organic peroxides are considered to be powerful explosives and are sensitive to heat, friction, impact, light, as well as to strong oxidizing and reducing agents. Peroxide formers react with oxygen even at low concentrations to form peroxy compounds. Autoxidation of organic material proceeds by a free-radical chain mechanism and commonly affects organic solvents. R-H R- R-O-O R-O-O-R (In the presence of oxygen) The instability of the molecule (R-O-O-R) can cause auto-decomposition simply by bumping or jarring the container, addition of heat, light, or opening the cap. The risk associated with the peroxide increases if the peroxide crystallizes or becomes concentrated by evaporation or distillation. Peroxide crystals may form on the container plug or the threads of the cap and detonate as a result of twisting the lid. Classes of Peroxide Formers Aldehydes Ethers - especially cyclic ethers and those containing primary and secondary alcohol groups Compounds containing benzylic hydrogen atoms (particularly if the hydrogens are on tertiary carbon atoms) Compounds containing the allylic structure, including most alkenes. Vinyl and vinylidene compounds. Preventing Formation of Organic Peroxides No single method of inhibition of peroxide formation is suitable for all peroxide formers. -
Hazardous Material Inventory Statement
City of Brooklyn Park FIRE DEPARTMENT 5200 - 85th Avenue North Brooklyn Park MN 55443 Phone: (763)493-8020 Fax: (763) 493-8391 Hazardous Materials Inventory Statement Users Guide A separate inventory statement shall be provided for each building. An amended inventory statement shall be provided within 30 days of the storage of any hazardous materials or plastics that changes or adds a hazard class or which is sufficient in quantity to cause an increase in the quantity which exceeds 5 percent for any hazard class. The hazardous materials inventory statement shall list by hazard class categories. Each grouping shall provide the following information for each hazardous material listed for that group including a total quantity for each group of hazard class. 1. Hazard class. (See attached Hazardous Materials Categories Listing) 2. Common or trade name. 3. Chemical Abstract Service Number (CAS number) found in 29 Code of Federal Regulations (C.F.R.). 4. Whether the material is pure or a mixture, and whether the material is a solid, liquid or gas 5. Maximum aggregate quantity stored at any one time. 6. Maximum aggregate quantity In-Use (Open to atmosphere) at any one time. 7. Maximum aggregate quantity In-Use (Closed to atmosphere) at any one time. 8. Storage conditions related to the storage type, high-pile, encapsulated, non-encapsulated. Attached is a listing of categories that all materials need to be organized to. Definitions of these categories are also attached for your use. At the end of this packet are blank forms for completing this project. For questions regarding Hazardous Materials Inventory Statement contact the Fire Department at 763-493-8020. -
Organic Peroxide and OH Formation in Aerosol and Cloud Water
Discussion Paper | Discussion Paper | Discussion Paper | Discussion Paper | Atmos. Chem. Phys. Discuss., 15, 17367–17396, 2015 www.atmos-chem-phys-discuss.net/15/17367/2015/ doi:10.5194/acpd-15-17367-2015 ACPD © Author(s) 2015. CC Attribution 3.0 License. 15, 17367–17396, 2015 This discussion paper is/has been under review for the journal Atmospheric Chemistry Organic peroxide and and Physics (ACP). Please refer to the corresponding final paper in ACP if available. OH formation in aerosol and cloud Organic peroxide and OH formation in water aerosol and cloud water: laboratory Y. B. Lim and B. J. Turpin evidence for this aqueous chemistry Title Page Y. B. Lim and B. J. Turpin Abstract Introduction Department of Environmental Sciences, Rutgers University, New Brunswick, NJ 08901, USA Conclusions References Received: 29 May 2015 – Accepted: 01 June 2015 – Published: 25 June 2015 Tables Figures Correspondence to: Y. B. Lim ([email protected]) J I Published by Copernicus Publications on behalf of the European Geosciences Union. J I Back Close Full Screen / Esc Printer-friendly Version Interactive Discussion 17367 Discussion Paper | Discussion Paper | Discussion Paper | Discussion Paper | Abstract ACPD Aqueous chemistry in atmospheric waters (e.g., cloud droplets or wet aerosols) is well 15, 17367–17396, 2015 accepted as an atmospheric pathway to produce secondary organic aerosol (SOAaq). Water-soluble organic compounds with small carbon numbers (C2-C3) are precursors 5 for SOAaq and products include organic acids, organic sulfates, and high molecular Organic peroxide and weight compounds/oligomers. Fenton reactions and the uptake of gas-phase OH rad- OH formation in icals are considered to be the major oxidant sources for aqueous organic chemistry. -
160 'Ideal' Gases: Anaesthetics in the Heart of the Twentieth Century Ian
International Workshop on the History of Chemistry 2015 Tokyo ‘Ideal’ Gases: Anaesthetics in the Heart of the Twentieth Century Ian D. Rae University of Melbourne, Australia 1. Introduction By 1920 only three gaseous anaesthetics were widely used – nitrous oxide, diethyl ether (ether) and chloroform. The toxicity of chloroform was acknowledged, nitrous oxide did not induce deep anaesthesia, and ether was extremely inflammable, so in the 1920s there were good reasons to search for new anaesthetics. While my concern is with gaseous anaesthetics, I recognise that there were parallel developments in two related fields, that of topical or local anaesthetics, typified by the natural product cocaine and a host of synthetic substances, and injectable anaesthetics starting with opiates, then barbiturates and leading to modern materials such as propofol (2,6-diisopropylphenol). 2. Theories of anaesthetic action Hans Meyer1 noted that the anaesthetic substances were soluble in both fatty and aqueous media, proposed a general theory of anaesthesia based on the partition or distribution coefficient as a critical determinant. Meyer enunciated the following three principles that underpinned his theory: all chemically inert substances that are soluble in fats and fatty materials will produce narcosis; the line of action is in the nerve cells; the comparative strengths of substances depend on their solubility in fatty material and in water, that is, on the distribution coefficient. Charles Overton arrived at the same idea independently. Some years after completing his PhD research on cell permeability studies, Overton first presented his theory of narcosis in a lecture to the Society for Natural History in Zurich in October 1898, in a paper published the following year2 and in his book3 which included a full exposition. -
Addressing Highly Hazardous Pesticides in Mozambique
República de Moçambique Ministério da Agricultura e Segurança Alimentar Direcção Nacional de Agricultura e Silvicultura Addressing Highly Hazardous Pesticides in Mozambique Addressing Highly Hazardous Pesticides in Mozambique Food and Agriculture Organization of the United Nations Rome, 2016 The designations employed and the presentation of material in this information product do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) concerning the legal or development status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by FAO in preference to others of a similar nature that are not mentioned. The views expressed in this information product are those of the author(s) and do not necessarily reflect the views or policies of FAO. ISBN 978-92-5-108519-6 © FAO, 2016 FAO encourages the use, reproduction and dissemination of material in this information product. Except where otherwise indicated, material may be copied, downloaded and printed for private study, research and teaching purposes, or for use in non-commercial products or services, provided that appropriate acknowledgement of FAO as the source and copyright holder is given and that FAO’s endorsement of users’ views, products or services is not implied in any way. All requests for translation and adaptation rights, and for resale and other commercial use rights should be made via www.fao.org/contact-us/licence-request or addressed to [email protected]. -
Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019 Theinternational Programme on Chemical Safety (IPCS) Was Established in 1980
The WHO Recommended Classi cation of Pesticides by Hazard and Guidelines to Classi cation 2019 cation Hazard of Pesticides by and Guidelines to Classi The WHO Recommended Classi The WHO Recommended Classi cation of Pesticides by Hazard and Guidelines to Classi cation 2019 The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019 TheInternational Programme on Chemical Safety (IPCS) was established in 1980. The overall objectives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from exposure to chemicals, through international peer review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals. This publication was developed in the IOMC context. The contents do not necessarily reflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organization Programme for the Sound Management of Chemicals (IOMC) was established in 1995 following recommendations made by the 1992 UN Conference on Environment and Development to strengthen cooperation and increase international coordination in the field of chemical safety. The Participating Organizations are: FAO, ILO, UNDP, UNEP, UNIDO, UNITAR, WHO, World Bank and OECD. The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organizations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment. WHO recommended classification of pesticides by hazard and guidelines to classification, 2019 edition ISBN 978-92-4-000566-2 (electronic version) ISBN 978-92-4-000567-9 (print version) ISSN 1684-1042 © World Health Organization 2020 Some rights reserved. -
A Review of Aluminium Phosphide Poisoning and a Flowchart to Treat It Arh Hig Rada Toksikol 2016;67:183-193 183
Hashemi-Domeneh, et al. A review of aluminium phosphide poisoning and a flowchart to treat it Arh Hig Rada Toksikol 2016;67:183-193 183 Review DOI: 10.1515/aiht-2016-67-2784 A review of aluminium phosphide poisoning and a flowchart to treat it Behrooz Hashemi-Domeneh1,2, Nasim Zamani1,2, Hossein Hassanian-Moghaddam1,2, Mitra Rahimi1,2, Shahin Shadnia1,2, Peyman Erfantalab1,2, and Ali Ostadi1,2 Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences1, Excellence Center of Clinical Toxicology, Iranian Ministry of Health2, Tehran, Iran [Received in February 2016; CrossChecked in February 2016; Accepted in September 2016] The use of pesticides such as aluminium phosphide (AlP) has increased in the recent years and improved the quantity and quality of agricultural products in a number of developing countries. The downside is that AlP causes severe chronic and acute health effects that have reached major proportions in countries such as India, Iran, Bangladesh, and Jordan. Nearly 300,000 people die due to pesticide poisoning in the world every year. Poisoning with AlP accounts for many of these deaths. Unfortunately, at the same time, there is no standard treatment for it. The aim of this article is to give a brief review of AlP poisoning and propose a treatment flowchart based on the knowledge gained so far. For this purpose we reviewed all articles on the management of AlP poisoning published from 2000 till now. Using a modified Delphi design, we have designed a handy flowchart that could be used as a guide for AlP poisoning management of patients in emergency centres. -
List of Class 1 Designated Chemical Substances
List of Class 1 Designated Chemical Substances *1:CAS numbers are to be solely as references. They may be insufficient or lacking, in case there are multiple chemical substances. No. Specific Class 1 CAS No. (PRTR Chemical (*1) Name Law) Substances 1 - zinc compounds(water-soluble) 2 79-06-1 acrylamide 3 140-88-5 ethyl acrylate 4 - acrylic acid and its water-soluble salts 5 2439-35-2 2-(dimethylamino)ethyl acrylate 6 818-61-1 2-hydroxyethyl acrylate 7 141-32-2 n-butyl acrylate 8 96-33-3 methyl acrylate 9 107-13-1 acrylonitrile 10 107-02-8 acrolein 11 26628-22-8 sodium azide 12 75-07-0 acetaldehyde 13 75-05-8 acetonitrile 14 75-86-5 acetone cyanohydrin 15 83-32-9 acenaphthene 16 78-67-1 2,2'-azobisisobutyronitrile 17 90-04-0 o-anisidine 18 62-53-3 aniline 19 82-45-1 1-amino-9,10-anthraquinone 20 141-43-5 2-aminoethanol 21 1698-60-8 5-amino-4-chloro-2-phenylpyridazin-3(2H)-one; chloridazon 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3-cyano- 22 120068-37-3 4[(trifluoromethyl)sulfinyl]pyrazole; fipronil 23 123-30-8 p-aminophenol 24 591-27-5 m-aminophenol 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one; 25 21087-64-9 metribuzin 26 107-11-9 3-amino-1-propene 27 41394-05-2 4-amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one; metamitron 28 107-18-6 allyl alcohol 29 106-92-3 1-allyloxy-2,3-epoxypropane 30 - n-alkylbenzenesulfonic acid and its salts(alkyl C=10-14) 31 - antimony and its compounds 32 120-12-7 anthracene 33 1332-21-4 asbestos ○ 34 4098-71-9 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate 35 78-84-2 isobutyraldehyde