An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001836235-HmpCyc: Bacillus sp. HMSC036E02 Cellular Overview Connections between pathways are omitted for legibility. aspglutamate phosphate putrescine putrescine (2-aminoethyl) ammonium glycine betaine 4-aminobutanoate pro pro phosphate phosphate phosphate phosphate spermidine spermidine phosphonate pro

ammonium predicted ABC predicted predicted transporter of ABC ABC RS15845 RS28740 RS04460 RS16570 RS11965 RS06940 RS14890 RS20820 RS04115 RS21030 RS16675 RS25885 (2-aminoethyl) transporter transporter phosphonate of phosphate of phosphate

putrescine putrescine ammonium glycine betaine phosphate 4-aminobutanoate ammonium spermidine spermidine asp pro pro pro phosphate phosphate (2-aminoethyl) glutamate phosphonate phosphate phosphate

Macromolecule Modification Amino Acid Degradation Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Other Biosynthesis an inactive 1-stearoyl- an [amino group carrier 1-cis-vaccenoyl- 1-myristoyl- a 1-acyl-sn D-gluconate tRNA processing a (3Z)-dodec- a ribonucleoside [2Fe-2S] iron-sulfur cluster biosynthesis L-valine degradation I a reduced a palmitoyl-[acp] sn-glycerol a malonyl-[acp] a purine a purine a purine 2'- protein]-C-terminal-γ- sn-glycerol- sn-glycerol -glycerol 3- 3'-AMP superpathway of menaquinol-7 biosynthesis superpathway of tetrahydrofolate biosynthesis thiamine formation from pyrithiamine and oxythiamine (yeast) (R,R)-butanediol L-isoleucine degradation I ribonucleoside arsenate 3'-phosphate 6-phosphate superpathway of thiamine diphosphate biosynthesis II Cell Structure Biosynthesis SAM 3-enoyl-[acp] ribonucleoside ribonucleoside deoxyribonucleoside (L-ornithyl)-L-glutamate 3-phosphate phosphate 6-phosphogluconate biosynthesis triphosphate flavodoxin 3-phosphate1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- acetylornithine 3-phosphate 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- bifunctional 2',3'- bifunctional 2',3'- a polycistronic anaerobic ribonucleoside- purine-nucleoside purine-nucleoside purine-nucleoside dehydrogenase val reductase phosphate acyltransferase: protein] synthase II: aminotransferase: phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: cyclic nucleotide 2'- cyclic-nucleotide 2'- L-cysteine desulfurase chorismate pyrithiamine a ThiS sulfur- tRNA precursor L-ornithine degradation II (Stickland reaction) triphosphate reductase phosphorylase: phosphorylase: phosphorylase: (decarboxylating): peptidoglycan biosynthesis I (meso-diaminopimelate containing) (R)-acetoin ile HMPREF2590_RS03160 HMPREF2590_RS12485 HMPREF2590_RS01280 HMPREF2590_RS03160 HMPREF2590_RS03160 HMPREF2590_RS03160 phosphodiesterase/ phosphodiesterase/ GTP carrier protein activating protein: HMPREF2590_RS16725 HMPREF2590_RS16725 HMPREF2590_RS16725 cys RS29640 cys cys (R,R)-butanediol branched-chain-amino- 3'-nucleotidase HMPREF2590_RS03010 3'-nucleotidase: cysteine desulfurase: isochorismate thiaminase II: UDP-N-acetyl- branched-chain-amino- HMPREF2590_RS03525 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- acetylornithine 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- dehydrogenase: acid transaminase: purine-nucleoside purine-nucleoside purine-nucleoside 6-phosphogluconate HMPREF2590_RS06475 HMPREF2590_RS07830 synthase EntC: HMPREF2590_RS13865 ThiS adenylyltransferase: α-D-glucosamine acid transaminase: L-ornithine phosphate acyltransferase: protein] synthase II: transaminase: phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: precursor protein: GTP cyclohydrolase I FolE: cysteine desulfurase: HMPREF2590_RS25325 HMPREF2590_RS16390 anaerobic ribonucleoside- phosphorylase: phosphorylase: phosphorylase: [+ 2 isozymes] HMPREF2590_RS02635 HMPREF2590_RS24970 (R,R)-2,3- HMPREF2590_RS16390 HMPREF2590_RS23435 HMPREF2590_RS12060 HMPREF2590_RS06505 1,2-dicis- HMPREF2590_RS23435 HMPREF2590_RS23435 HMPREF2590_RS23435 HMPREF2590_RS23930 dehydrogenase bifunctional 2',3'- HMPREF2590_RS16970 thiaminase II: HMPREF2590_RS07830 UDP-N-acetylglucosamine a tRNA precursor triphosphate reductase 1-stearoyl- a (5Z)-3-oxo- HMPREF2590_RS06295 HMPREF2590_RS06295 α HMPREF2590_RS06295 an [amino group carrier 1-myristoyl-2- a 1-acyl-2- butanediol exoribonuclease: branched-chain-amino- α-D-ribose- 2-deoxy- - (decarboxylating): riboflavin RS16815 riboflavin isochorismate synthase: HMPREF2590_RS25010 [+ 2 isozymes] a carboxy- 1-carboxyvinyltransferase: with a 5' extension branched-chain-amino- 2-palmitoyl- acyl-carrier protein tetradec-5- protein]-C-terminal-γ-(L- vaccenoyl- palmitoleoyl- palmitoyl-sn bifunctional 2',3'- cyclic nucleotide 2'- an S-sulfanyl-[L- 7,8- HMPREF2590_RS22120 acid transaminase: ornithine--oxo-acid activating protein: acyl-carrier protein ribose-1-arsenate a purine base a purine base D-ribose 1- a purine base HMPREF2590_RS19090 HMPREF2590_RS27640 4-amino-2-methyl-5- an [L-cysteine adenylated- HMPREF2590_RS22970 acid transaminase: an active sn-glycerol enoyl-[acp] 1-phosphate glutamate 5-semialdehyde- phosphatidate sn-glycerol -glycerol 3- cyclic-nucleotide 2'- phosphodiesterase/ cysteine desulfurase] dihydroneopterin and a long 3' trailer a tRNA precursor with HMPREF2590_RS09545 transaminase: HMPREF2590_RS20600 phosphate D-ribulose pyrimidinemethanol desulfurase]-S- [ThiS sulfur- HMPREF2590_RS09545 (S)-3-methyl-2- a flavodoxin ribonucleoside 3-phosphate 2-yl)-L-glutamate 3-phosphate phosphate phosphodiesterase/ 3'-nucleotidase isochorismate 3'-triphosphate AIR D-glyceraldehyde UDP-N-acetylglucosamine a 5' extension and HMPREF2590_RS11935 met 5'-deoxyadenosine 5-phosphate sulfanyl-L-cysteine carrier protein] 3-methyl-2- oxopentanoate semiquinone triphosphate 3'-nucleotidase: precursor protein: bifunctional 3-phosphate 1-carboxyvinyltransferase: a short 3' extension D-ornithine predicted gly RNase BN ribonuclease:ribonuclease PH: HMPREF2590_RS06475 HMPREF2590_RS23930 2-succinyl-6-hydroxy- hydroxymethylpyrimidine phosphomethylpyrimidine HMPREF2590_RS26315 ribonuclease P oxobutanoate reductase ABC efflux 1-deoxy-D-xylulose-5- cysteine desulfurtrase: HMPREF2590_RS22120HMPREF2590_RS09085 L-glutamate-5- an S-sulfanyl-[cysteine 2, 4-cyclohexadiene-1- synthase: α protein component: a ribonucleoside thiol transporter thiol 7,8- kinase/ phosphate synthase: UDP-N-acetyl- - semialdehyde adenosine desulfurase]-[disordered- flavin biosynthesis I (bacteria and plants) HMPREF2590_RS11295 glycine oxidase ThiO: HMPREF2590_RS03710 of a thiol carboxylate synthase: phosphomethylpyrimidine HMPREF2590_RS22625 HMPREF2590_RS06755 D-glucosamine- form scaffold dihydroneopterin HMPREF2590_RS24985 2-methylbutanoyl-CoA group HMPREF2590_RS27630 3'-phosphate kinase: 1-deoxy-D- enolpyruvate a tRNA precursor with protein] complex HMP-P a thiocarboxy- a tRNA precursor (2R,4S)-2, 4- [cysteine desulfurase]-S- 2-succinyl-5-enolpyruvyl-6- HMPREF2590_RS26710 xylulose 5- UDP-N- a short 3' extension isobutanoyl-CoA Peptide RS03030 Peptide [ThiS-Protein] 2-iminoacetate with a 5' extension GTP diaminopentanoate 1-stearoyl- a 1-alkyl-sn 1-palmitoyl- 1939 sulfanylcysteine:[acceptor hydroxy-3- cyclohexene-1- bifunctional bifunctional phosphate acetylenolpyruvoylglucosamine (S)-1-pyrroline- undecaprenyl- a cis- sn-glycerol 1-(18-hydroxyoleoyl)- 5'-deoxy-5'- sn-glycerol a uracil sn-glycerol a stearoyl-[acp] sn-glycerol a protein -glycerol 3- sn-glycerol 3'-GMP protein]-cysteine carboxylic-acid synthase: hydroxymethylpyrimidine hydroxymethylpyrimidine reductase: ribonuclease PH: 5-carboxylate diphospho-N- vaccenoyl-[acp] 3-phosphate inosine sn-glycrol 3-phosphate fluoroadenosine 3-phosphate in 23S rRNA 3-phosphate sulfurtransferase: HMPREF2590_RS27635 7,8- GTP cyclohydrolase II RibA: thiazole synthase: HMPREF2590_RS22000 ribonuclease: (E)-2- acetylmuramoyl- UDP-N-acetyl- 3-phosphate1-acyl-sn-glycerol-3- glycerol-3-phosphate ATP-dependent Clp 1-acyl-sn-glycerol-3- purine-nucleoside phosphate 3-phosphate glycerol-3-phosphate 23S rRNA glycerol-3-phosphate bifunctional 2',3'- chorismate kinase/ kinase/ HMPREF2590_RS09085 pyrroline-5- inosine-uridine preferring 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- + + dihydroneopterin methylcrotonoyl-CoA γ α phosphorylase: (uracil(1939)-C(5))- Na RS06225 Na HMPREF2590_RS07830 2-succinyl-5- HMPREF2590_RS19140 phosphomethylpyrimidine phosphomethylpyrimidine HMPREF2590_RS24975 UDP-N- HMPREF2590_RS03710 L-alanyl- -D- -D-glucosamine phosphate acyltransferase: acyltransferase: protease proteolytic subunit: phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: acyltransferase: acyltransferase: cyclic-nucleotide 2'- a [cysteine desulfurase]- methylacrylyl-CoA carboxylate reductase: (2R)-2-amino-4- undecaprenyldiphospho- nucleoside hydrolase: HMPREF2590_RS16725 methyltransferase RlmD: enolpyruvoyl-6- dihydroneopterin aldolase: aminodeoxychorismate/ bifunctional 3,4- kinase: thiamine salvage II kinase: acetylenolpyruvoylglucosamine glutamyl-L-lysyl- HMPREF2590_RS03160 HMPREF2590_RS08825 HMPREF2590_RS22230 HMPREF2590_RS03160 HMPREF2590_RS23435 HMPREF2590_RS03160 HMPREF2590_RS08825 HMPREF2590_RS08825 phosphodiesterase/ S-sulfanyl-[disordered- 2-[(2R,5Z)- HMPREF2590_RS23495 oxopentanoate muramoylpentapeptide beta-N- HMPREF2590_RS22145 HMPREF2590_RS00740 hydroxy-3-cyclohexene- HMPREF2590_RS08000 anthranilate synthase dihydroxy-2-butanone- oxythiamine HMPREF2590_RS24965 HMPREF2590_RS26710 reductase: D-alanyl-D-alanine 1-acyl-sn-glycerol-3- glycerol-3-phosphate ATP-dependent Clp 1-acyl-sn-glycerol-3- purine-nucleoside glycerol-3-phosphate glycerol-3-phosphate 3'-nucleotidase: form scaffold 4-amino-2-methyl-5- 2-carboxy-4- [+ 3 isozymes] acetylglucosaminyltransferase: inosine-uridine preferring 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-carboxylate component II: 4-phosphate synthase/ HMPREF2590_RS05390 Metabolic Regulator phosphate acyltransferase: acyltransferase: protease proteolytic subunit: phosphate acyltransferase: phosphorylase: acyltransferase: 23S rRNA acyltransferase: HMPREF2590_RS06475 Fe 3+ RS10685 Fe 3+ protein] complex 6-(hydroxymethyl) pyrimidinemethanol bifunctional methylthiazol-5(2H (2S,3S)-3-hydroxy-2- ditrans,octacisHMPREF2590_RS05395- nucleoside hydrolase: phosphate acyltransferase: phosphate acyltransferase: 2-succinyl-6-hydroxy- HMPREF2590_RS08015 GTP cyclohydrolase II: thiaminase II: HMP-P ala Biosynthesis an uncharged tRNA HMPREF2590_RS23435 HMPREF2590_RS20610 HMPREF2590_RS14880 HMPREF2590_RS23435 HMPREF2590_RS06295 α ωHMPREF2590_RS20610 (uracil(1939)-C(5))- HMPREF2590_RS20610 cysteine desulfurase: -7,8-dihydropterin hydroxymethylpyrimidine )-ylidene]ethyl thiamine salvage IV (yeast) UDP-N-acetyl- (S)-3-hydroxy- methylbutanoyl-CoA pro undecaprenyldiphospho- 1-stearoyl-2- 1-cis-vaccenoyl- HMPREF2590_RS14390 1-[18-hydroxyoeoyl]-2- a 2-acyl-1-alkyl-HMPREF2590_RS03160 1-palmitoyl-2- HMPREF2590_RS23435 1-C16:0- , - 1-(18- bifunctional 2',3'- 2, 4-cyclohexadiene-1- 4-amino-4- HMPREF2590_RS06420 HMPREF2590_RS13865 bifunctional glu α [+ 2 isozymes] 5-fluoro-5- methyltransferase RlmD: HMPREF2590_RS07830 2-amino-4-hydroxy-6- kinase/ -D-muramate N-acetyl-(N-acetyl-β-D- stearoyl-sn acyl-carrier protein sn-glycerol- a peptide a peptide [18-hydroxy-lioleoyl]-sn sn-glycerol palmitoleoyl- dicarboxyl-2- hydroxyoleoyl) cyclic nucleotide 2'- carboxylate synthase: thiaminase II: bifunctional hydroxymethylpyrimidine phosphate ppGpp biosynthesis isobutanoyl-CoA UDP acyl-carrier protein hypoxanthine D-ribofuranose deoxy-D-ribose adenine HMPREF2590_RS28090 deoxychorismate 2,5-diamino-6-(5-phospho-D- phosphomethylpyrimidine proline racemase: D-ala glucosaminyl)muramoyl- -glycerol 3- 3-phosphate -glycerol 3-phosphate 3-phosphate sn-glycerol lysophosphatidate a 5- -sn-glycrol phosphodiesterase/ [+ 2 isozymes] hydroxymethyldihydropteridine hydroxymethylpyrimidine glutamate racemase: 1-phosphate L-cystine RS07075 L-cystine an S-sulfanyl-[cysteine HMPREF2590_RS27630 4-amino-4- HMPREF2590_RS25010 kinase/ thiamine UDP-N-acetylmuramate- 1939 (1R,6R)-6-hydroxy-2- diphosphokinase: ribosylamino)pyrimidin-4(3H)-one kinase: Electron Transfer HMPREF2590_RS15665 L-alanyl-γ-D-glutamyl-L- phosphate 3-phosphate methyluracil 3-phosphate 3'-nucleotidase desulfurase]-S- deoxychorismate lyase: 5-(2-hydroxyethyl) kinase/ phosphomethylpyrimidine HMPREF2590_RS09075 -L-alanine ligase: pppGpp succinylcyclohexa-2,4- HMPREF2590_RS07995 bifunctional HMPREF2590_RS24965 2-methylacetoacetyl-CoA proline racemase: lysyl-D-alanyl-D-alanine in 23S rRNA precursor protein: sulfanyl-[disordered- phosphomethylpyrimidine kinase: 2-(2-carboxy-4- glutamate racemase: HMPREF2590_RS11520 HMPREF2590_RS08010 -4-methylthiazole thiaminase II: queuosine biosynthesis (S)-3-hydroxy- HMPREF2590_RS14675 HMPREF2590_RS23930 diene-1-carboxylate (7,8-dihydropterin- diaminohydroxyphosphoribosylaminopyrimidine kinase: HMPREF2590_RS26710 methylthiazol-5- HMPREF2590_RS24370 ATP biosynthesis 2+ 2+ form scaffold HMP-PP GTP pyrophosphokinase: Cd RS25680 Cd o-succinylbenzoate 6-yl)methyl deaminase/5-amino-6-(5-phosphoribosylamino) 4-methyl-5(B-hydroxyethyl) HMPREF2590_RS13865 isobutanoate acetyl-CoA C- protein] complex 4-aminobenzoate HMPREF2590_RS26710 yl)ethyl phosphate UDP-N-acetyl- HMPREF2590_RS07565 guanosine [cysteine desulfurase]-S- diphosphate -thiazole monophosphate bifunctional guanosine 3'-diphosphate preQ 3-hydroxyisobutyrate acetyltransferase: D-proline synthase: uracil reductase RibD: HMPREF2590_RS06410 thiaminase II: D-glt α-D-muramoyl- 0 biosynthesis protein: bifunctional hydroxymethylpyrimidine [+ 2 isozymes] NADPH-dependent 7- HMPREF2590_RS05965 sulfanylcysteine:[acceptor HMPREF2590_RS27615 5-amino-6-(5-phospho- thiamine phosphate HMPREF2590_RS25010 L-alanine 5'-triphosphate 3'- ADP dehydrogenase: dihydropteroate synthase: HMPREF2590_RS20875 hydroxymethylpyrimidine kinase/ [+ 2 isozymes] protein]-cysteine D-ribosylamino)uracil synthase: diphosphatase: cyano-7-deazaguanine ATP synthase subunit I: HMPREF2590_RS02705 an anion RS02040 an anion kinase/ phosphomethylpyrimidine sulfurtransferase: 2-succinylbenzoate HMPREF2590_RS08005 hydroxyethylthiazole HMPREF2590_RS27815 4-amino-2-methyl-5- 5-(2-hydroxyethyl) UDP-N-acetylmuramoyl-L- HMPREF2590_RS07880 reductase QueF: (S)-methylmalonate- all-trans- a ribonucleoside bifunctional phosphomethylpyrimidine HMPREF2590_RS19000 propanoyl-CoA acetyl-CoA 1-cis-vaccenoyl- a reduced a ribonucleoside 5'-chloro-5'- 1-myristoyl- an N-hydroxy- HMPREF2590_RS07830 kinase: HMPREF2590_RS16120 1-myristoyl-sn- a cis- 2-carboxy-1,4- + + sn-glycerol 3'-UMP + + a [cysteine o-succinylbenzoate- diaminohydroxyphosphoribosylaminopyrimidine kinase: thiamine phosphate pyrimidinemethanol -4-methylthiazole alanine--D-glutamate ligase: [+ 4 isozymes] semialdehyde a palmitoleoyl-[acp] sn-glycerol- dodecaprenyl ferredoxin [iron- NADP H formate N-acetyl-L-citrulline deoxyadenosine sn-glycerol a malonyl-[acp] arylamine 2',3'-cyclic H RS27200 H 7,8- kinase: HMPREF2590_RS24965 preQ 5-aminopentanoate glycerol 3-phosphate vaccenoyl-[acp] naphthoquinol triphosphate 3-phosphate D-ribulose 5-phosphate HMPREF2590_RS27820 HMPREF2590_RS05405 1 diphosphate purine-nucleoside N-hydroxyarylamine phosphate desulfurase]-(S- -CoA ligase: deaminase/5-amino-6-(5-phosphoribosylamino) HMPREF2590_RS24965 synthase: bifunctional 4-methyl-5(B-hydroxyethyl) ATP 1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate sulfur] cluster ferredoxin--NADP(+) anaerobic ribonucleoside- acetylornithine deacetylase: 3-phosphate 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- bifunctional 2',3'- glycerol-3-phosphate bifunctional 2',3'- acetoin RS06260 acetoin dihydropteroate 4-methyl-5-(2- L-cysteine biosynthesis 4-aminobutyrate phosphorylase: O-acetyltransferase: sulfanyl) -[disordered- HMPREF2590_RS27620 uracil reductase RibD: HMPREF2590_RS06410 HMP-P HMPREF2590_RS24990 hydroxymethylpyrimidine -thiazole monophosphate GTP ppGpp tRNA guanosine(34) methylmalonate- phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: reductase: triphosphate reductase: HMPREF2590_RS00770 phosphate acyltransferase: protein] synthase II: acyltransferase: cyclic-nucleotide 2'- 2 bifunctional bifunctional 3,4- phosphooxyethyl) UDP-N-acetyl- cyclic nucleotide 2'- form scaffold HMP-PP VI (from L-methionine) kinase/ biosynthesis protein: meso- aminotransferase, semialdehyde HMPREF2590_RS03160 HMPREF2590_RS03160 HMPREF2590_RS21295 HMPREF2590_RS03520 HMPREF2590_RS16725 HMPREF2590_RS12485 HMPREF2590_RS19595 HMPREF2590_RS08825 phosphodiesterase/ 4-(2'-carboxyphenyl) dihydroxy-2-butanone- 5-amino-6-(5-phospho- thiazole α-D-muramoyl-L- transglycosylase Tgt: HMPREF2590_RS27645 acetylornithine deacetylase: HMPREF2590_RS03160 phosphodiesterase/ his RS01665 his folylpolyglutamate synthase/ bifunctional phosphomethylpyrimidine HMPREF2590_RS20875 mitochondrial: dehydrogenase L-tryptophan degradation to purine-nucleoside arylamine N- 3'-nucleotidase: protein] complex IPP (2E,6E)-farnesyl -4-oxobutyryl-CoA 4-phosphate synthase/ D-ribitylamino)uracil thiamine diaminopimelate HMPREF2590_RS07930 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate NAD(P)/FAD-dependent anaerobic ribonucleoside- HMPREF2590_RS02900 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- 3'-nucleotidase glycerol-3-phosphate dihydrofolate synthase: alanyl-D-glutamate HMPREF2590_RS28135 (CoA acylating): Ca 2+ 2+ diphosphate hydroxymethylpyrimidine met kinase: a 7-aminomethyl-7- 2-amino-3-carboxymuconate triphosphate reductase: phosphorylase: acetyltransferase: HMPREF2590_RS06475 RS00705 Ca 1,4-dihydroxy-2- HMPREF2590_RS09210 GTP cyclohydrolase II: thiamine phosphate phosphate hydroxyethylthiazole GTP pyrophosphokinase: phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: oxidoreductase: acetate L-citrulline phosphate acyltransferase: protein] synthase II: precursor protein: acyltransferase: kinase/ deazaguanosine 34 HMPREF2590_RS02700 L-arginine degradation HMPREF2590_RS06295 heptaprenyl naphthoyl-CoA synthase: HMPREF2590_RS06420 S-adenosylmethionine HMPREF2590_RS26710 kinase: UDP-N-acetylmuramoyl-L- HMPREF2590_RS07565 semialdehyde HMPREF2590_RS23435 HMPREF2590_RS23435 HMPREF2590_RS18215 HMPREF2590_RS27985 HMPREF2590_RS20605 HMPREF2590_RS12060 HMPREF2590_RS15240 HMPREF2590_RS23930 HMPREF2590_RS20610 bifunctional 2',3'- 7,8-dihydrofolate synthase: 5-(2-hydroxyethyl) D-ala VI (arginase 2 pathway) 1-myristoyl-2- 1,2-dicis- an oxidized 1,2-dimyristoyl-HMPREF2590_RS23435 a 3- an N- 1-oleoyl-sn ala ala phosphomethylpyrimidine synthase: HMPREF2590_RS27820 bifunctional (p)ppGpp in tRNA (S)-3-amino-2- a 2'-deoxyribonucleoside 5-chloro-5- cyclic nucleotide 2'- RS06220 a [cysteine desulfurase]- diphosphate synthase: HMPREF2590_RS27625 HMPREF2590_RS27815 -4-methylthiazole bifunctional alanyl-D-glutamate--2, 6- GTP pyrophosphokinase: trp acyl-carrier protein palmitoleoyl-sn- acyl-carrier protein vaccenoyl- DMK-12 NADPH ferredoxin [iron- sn-glycerol oxodocosanoyl- [+ 3 isozymes] -glycerol 3- met met monoglutamate 1-deoxy-L-glycero- kinase: HMPREF2590_RS27190 4-methyl-5-(2- synthetase/guanosine- tRNA preQ1(34) S- methylpropanoate 5'-triphosphate adenine deoxyribose acetoxyarylamine a ribonucleoside [scaffold protein- HMPREF2590_RS16975 1,4-dihydroxy-2- ARP hydroxymethylpyrimidine diaminopimelate ligase: nucleoside- HMPREF2590_RS04350 hydrogencarbonate glycerol 3-phosphate phosphatidate sulfur] cluster 3-phosphate [acp] phosphate phosphodiesterase/ chloride RS26680 chloride tetrulose 4-phosphate thiamine phosphate 4-methyl-5(B-hydroxyethyl) HMPREF2590_RS26710 SAM phosphooxyethyl) D-alanine--D-alanine ligase: 3',5'-bis(diphosphate) 3'- adenosylmethionine tryptophan 2,3- arg 1-phosphate (2Fe-2S)] complex heptaprenyl diphosphate naphthoyl-CoA thiamine kinase/ HMPREF2590_RS05415 diphosphate kinase: 3'-phosphate 3'-nucleotidase synthase: -thiazole monophosphate thiazole HMPREF2590_RS13860 pyrophosphohydrolase: ribosyltransferase- dioxygenase: synthase component II: bifunctional diphosphate phosphomethylpyrimidine HMPREF2590_RS16990 arginase: precursor protein: 6,7-dimethyl-8- HMPREF2590_RS24990 biosynthesis protein: thiamine phosphate D-alanine--D- HMPREF2590_RS07880 isomerase QueA: HMPREF2590_RS15055 met RS21605 met HMPREF2590_RS16985 hydroxymethylpyrimidine kinase: UDP-N-acetyl- N-formylkynurenine HMPREF2590_RS23635 HMPREF2590_RS23930 a cyclic a cyclic a 7,8-dihydrofolate ribityllumazine synthase: HMPREF2590_RS20875 α alanine ligase B: GDP HMPREF2590_RS07935 RS12590 kinase/ HMPREF2590_RS24965 synthase: -D-muramoyl- L-ornithine uridine peptide peptide a [co-chaperone]- HMPREF2590_RS06425 thiamine hydroxyethylthiazole HMPREF2590_RS12145 all-trans-heptaprenyl 2-carboxy-1,4- phosphomethylpyrimidine thiamine salvage III HMPREF2590_RS27815 L-alanyl-γ-D- an epoxyqueuosine 34 L-histidine degradation I arylformamidase: [scaffold protein- dihydrofolate reductase: kinase: diphosphate naphthoquinol phosphate kinase: SAH HMP-P thiamine phosphate glutamyl-meso-2,6- in tRNA HMPREF2590_RS15050 ornithine--oxo-acid met RS23575 met (2Fe-2S)] complex HMPREF2590_RS03175 HMPREF2590_RS27820 D-alanyl-D-alanine 1-palmitoyl- all-trans- DNA combined with 1-palmitoyl- guanosine α HMPREF2590_RS24965 synthase: diaminopimelate transaminase: 1-cis-vaccenoyl-sn- 2-carboxy-1,4- sn-glycerol 1-cis-vaccenoyl-sn- α-D- CDP-α-D-glucose a [protein]- - 3'-cmp dihydrofolate reductase: 6,7-dimethyl-8-(1-D-ribityl)lumazine 4-methyl-5-(2- thiamine epoxyqueuosine reductase: his a palmitoleoyl-[acp] sn-glycerol a myristoyl-[acp] undecaprenyl a myristoyl-[acp] 2-oxoglutarate D-ala exogenous DNA to form sn-glycerol 2',3'-cyclic lactate RS04065 lactate 1,4-dihydroxy-2-naphthoate 5'-methylthioadenosine/ bifunctional HMPREF2590_RS24990 HMPREF2590_RS11935 glycerol-3-phosphate naphthoquinol 3-phosphate glycerol-3-phosphate glucopyranose ATP CDP-glucose 4,6- L-glutamate HMPREF2590_RS25425 phosphooxyethyl) thiamine diphosphokinase: HMPREF2590_RS25950 L-kynurenine 3-phosphate diphosphate a recombinational junction 3-phosphate monophosphate protein-glutamate O- bifunctional 2',3'- polyprenyltransferase: riboflavin synthase: HMP-PP S-adenosylhomocysteine hydroxymethylpyrimidine UDP-N-acetylmuramoyl- histidine ammonia-lyase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate glycerol-3-phosphate D-amino-acid transaminase: Holliday junction 1-acyl-sn-glycerol-3- 1-phosphate 1-acyl-sn-glycerol-3- dehydratase: bifunctional 2',3'- thiamine 34 L-glutamate-5- met RS28205 met a [chaperone-ATP]- thiazole nucleosidase: HMPREF2590_RS05145 kinase/ tripeptide--D-alanyl- a queuosine HMPREF2590_RS20860 phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: acyltransferase: HMPREF2590_RS22655 resolvase RuvX: phosphate acyltransferase: glucose-1-phosphate phosphate acyltransferase: cyclic-nucleotide 2'- methyltransferase CheR: cyclic-nucleotide 2'- HMPREF2590_RS27645 a tetrahydrofolate HMPREF2590_RS06415 molybdenum cofactor biosynthesis thiamine phosphate semialdehyde HMPREF2590_RS19025 [co-chaperone]- phosphomethylpyrimidine in tRNA urocanate HMPREF2590_RS03160 HMPREF2590_RS03160 HMPREF2590_RS08825 HMPREF2590_RS03160 adenylyltransferase: HMPREF2590_RS03160 HMPREF2590_RS17590 phosphodiesterase/ 1,4-dihydroxy-2-naphthoate HMPREF2590_RS07710 diphosphate D- alanine ligase: HMPREF2590_RS27645 D-amino-acid transaminase: HMPREF2590_RS07775 CDP-glucose 4,6- phosphodiesterase/ nitrate RS00225 nitrate thiamine phosphate kinase: HMPREF2590_RS27690 protein-glutamate O- 3'-nucleotidase: [scaffold protein- polyprenyltransferase: riboflavin [+ 4 isozymes] HMPREF2590_RS12140 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate glycerol-3-phosphate HMPREF2590_RS03090 resolution of recombinational[+ 2 isozymes] 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- dehydratase: 3'-nucleotidase: lipoate salvage I synthase: HMPREF2590_RS26710 urocanate hydratase: methyltransferase CheR: HMPREF2590_RS06475 (2Fe-2S)] complex HMPREF2590_RS18215 GTP 3-hydroxy- phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: acyltransferase: pyruvate D-glt junction formation phosphate acyltransferase: glucose-1-phosphate phosphate acyltransferase: HMPREF2590_RS06475 gln RS25470 gln bifunctional riboflavin HMPREF2590_RS27815 S-ribosyl-L- HMPREF2590_RS20855 HMPREF2590_RS19745 HMPREF2590_RS13230 UDP-N-acetyl- L-kynurenine HMPREF2590_RS23435 HMPREF2590_RS23435 HMPREF2590_RS18215 HMPREF2590_RS20610 of two intact strands HMPREF2590_RS23435 adenylyltransferase: HMPREF2590_RS23435 [+ 3 isozymes] a [protein]-L- bifunctional 2',3'- kinase/FAD synthetase: cys ATP homocysteine bifunctional α (S)-1-pyrroline- 1-cis-vaccenoyl- 1-palmitoyl- 1-myristoyl- 1-cis-vaccenoyl- 1-palmitoyl- CDP-4-dehydro- pyridoxal 5'-phosphate biosynthesis I thiamine phosphate thiamine -D-muramoyl- Aminoacyl-tRNA Charging lipoprotein posttranslational HMPREF2590_RS27695 5 predicted (R)-lipoate hydroxymethylpyrimidine 4-imidazolone- acyl-carrier protein 2-palmitoleoyl-sn- acyl-carrier protein 2-myristoyl DMKH2-11 acyl-carrier protein sn-glycerol 2-palmitoleoyl-sn- 2-myristoyl 6-deoxy-D-glucose 3'-GMP glutamate-O cyclic nucleotide 2'- demethylmenaquinol-7 HMPREF2590_RS04890 GTP 3',8-cyclase MoaA: synthase: S-ribosylhomocysteine L-alanyl-γ-D- modification kynureninase: 5-carboxylate ADP-α-D-glucose ABC lipoate--protein ligase A: cysteine desulfurase: kinase/ 5-propanoate glycerol-3-phosphate phosphatidate 3-phosphate glycerol-3-phosphate phosphatidate -methyl-ester phosphodiesterase/ D-ribose D-ribose D-erythrose HMPREF2590_RS20430 HMPREF2590_RS24990 lyase: thiamine diphosphokinase: glutamyl-meso-2,6- di-trans,octa-cis HMPREF2590_RS15045 pyrroline-5- ala RS02575 ala transporter a [chaperone- HMPREF2590_RS11695 FMN HMPREF2590_RS07830 phosphomethylpyrimidine tRNA charging a [prolipoprotein]- 3'-nucleotidase an [2Fe-2S] demethylmenaquinone 4-phosphate [+ 2 isozymes] HMPREF2590_RS27320 HMPREF2590_RS05145 glutaminyl-tRNA gln imidazolonepropionase: carboxylate reductase: of D-ribose ADP]-[disordered- diaminopimeloyl- -undecaprenyl precursor protein: cluster protein methyltransferase: (lipoyl)adenylate [+ 2 isozymes] (8S)-3',8-cyclo-7,8- kinase: arginine--tRNA ligase: L-cysteine HMPREF2590_RS20850 HMPREF2590_RS23495 form scaffold bifunctional riboflavin an [L-cysteine a carboxy-adenylated thiamine D-alanyl-D-alanine phosphate biosynthesis via 3-hydroxyanthranilate HMPREF2590_RS23930 HMPREF2590_RS16980 dihydroguanosine L-homocysteine HMPREF2590_RS24965 thiamine HMPREF2590_RS03330 prolipoprotein 2+ 2+ protein] complex kinase/FAD synthetase: phosphate transamidation [+ 3 isozymes] Zn RS02510 Zn lipoate--protein ligase A: desulfurase]-S- [small subunit of 5'-triphosphate diphosphate arg diacylglyceryl transferase: N-formimino- L-proline degradation cytidine sulfate RS22345 sulfate HMPREF2590_RS04890 HMP-PP arginine--tRNA ligase: menaquinol-7 4-phospho- HMPREF2590_RS11695 sulfanyl-L-cysteine molybdopterin synthase] cyclic pyranopterin HMPREF2590_RS22290 L-glutamate lipoate salvage II HMPREF2590_RS26470 an L-arginyl- glu pro D-erythronate a [lipoyl-carrier monophosphate FAD Arg prolipoprotein L-tryptophan degradation 1-palmitoyl- an all-trans- a (7Z,10Z,13Z,16Z 1-palmitoyl- cytidine 2',3'-cyclic adenosine 6 undecaprenyldiphospho- [tRNA ] formimidoylglutamase: pro aminocarboxymuconate phosphoenol an [HPr]- (S)-4-amino-5- an [Fe-S cluster a [disordered- protein]-N - synthase MoaC: 1-palmitoyl-sn- 2-carboxy-1,4- sn-glycerol a ribonucleoside NMN lys RS03640 lys a [lipoyl-carrier a tRNA Arg diacylglyceryl transferase: HMPREF2590_RS20845 I (via anthranilate) a palmitoleoyl-[acp] a palmitoyl-[acp] sn-glycerol polyisoprenyl a palmitoyl-[acp] ,19Z)-3-oxodocosa- sn-glycerol monophosphate 2',3'-cyclic MEP predicted thiamine N-acetylmuramoyl-L- proline dehydrogenase: semialdehyde glycerol 3-phosphate naphthoquinol 3-phosphate pyruvate L-histidine diphosphate oxopentanoate biosynthesis form [Fe-S] cluster lipoyl-L-lysine HMPREF2590_RS12350 protein]-N 6 - an L-glutamyl- HMPREF2590_RS18055 diphosphate phosphoenolpyruvate- glutamate-1-semialdehyde 3-phosphate bifunctional 2',3'- monophosphate bifunctional a thiocarboxylated diphosphate L-cystathionine alanyl-γ-D-glutamyl-meso HMPREF2590_RS21700 1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate glycerol-3-phosphate 7,10,13,16,19-pentaenoyl-[acp]3-oxoacyl-[acyl-carrier- ribonucleotide-diphosphate 1-acyl-sn-glycerol-3- bifunctional 2',3'- 1-deoxy-D-xylulose- ABC chaperone]-ATP scaffold protein] cyclic pyranopterin N 10 -formyl-tetrahydrofolate biosynthesis lipoyl-L-lysine [tRNA Gln ] -protein 2,1-aminomutase: cyclic-nucleotide 2'- metallophosphatase/ sulfate sulfate (3R)-3-hydroxy-2-oxo- [small subunit of -2,6-diaminopimeloyl- a [prolipoprotein]-S- glu proline dehydrogenase: trp phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: acyltransferase: protein] reductase: reductase subunit beta: phosphate acyltransferase: cyclic-nucleotide 2'- 5-phosphate transporter phosphate phosphotransferase: HMPREF2590_RS00955 phosphodiesterase/ 5'-nucleotidase: 4 phosphooxybutanoate molybdopterin synthase] D-alanyl-D-alanine Asp-tRNA(Asn) diacylglyceryl-L-cysteine HMPREF2590_RS12850 L-threonine degradation tryptophan 2,3- HMPREF2590_RS03160 HMPREF2590_RS03160 HMPREF2590_RS18215 HMPREF2590_RS08825 HMPREF2590_RS05100 HMPREF2590_RS16175 HMPREF2590_RS03160 phosphodiesterase/ reductoisomerase: of sulfate (S)-1-pyrroline- HMPREF2590_RS06095 3'-nucleotidase: HMPREF2590_RS21560 3-phosphoserine/ a tetrahydrofolate (R)-lipoate undecaprenyldiphospho- /Glu-tRNA(Gln) III (to methylglyoxal) dioxygenase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- glycerol-3-phosphate [+ 7 isozymes] an [HPr protein]- ribonucleoside- glutamate-1-semialdehyde 3'-nucleotidase: HMPREF2590_RS18930 NAD salvage pathway I 5-carboxylate 1,4-dihydroxy-2-naphthoate a (3R,7Z,10Z,13Z,16Z 1-acyl-sn-glycerol-3- HMPREF2590_RS06475 molybdopterin synthase: muramoylpentapeptide beta-N- cys lipoprotein π 2,1-aminomutase: HMPREF2590_RS06475 [+ 2 isozymes] sulfite RS16670 sulfite phosphohydroxythreonine heme b biosynthesis I (aerobic) cysteine--tRNA ligase: amidotransferase HMPREF2590_RS15055 phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: acyltransferase: ,19Z)-3-hydroxydocosa- N -phospho- pyruvate diphosphate reductase: phosphate acyltransferase: 1-(β-D 1-deoxy-D-xylulose- NAD biosynthesis I (from aspartate) siroheme biosynthesis HMPREF2590_RS00235 phosphopantothenate biosynthesis I lipoate--protein ligase A: acetylglucosaminyltransferase: subunit GatA: gatA signal peptidase: thr N-formylkynurenine HMPREF2590_RS09190 [+ 3 isozymes] transaminase: cys HMPREF2590_RS08405 an L-cysteinyl- HMPREF2590_RS234351-palmitoyl-2- HMPREF2590_RS23435 HMPREF2590_RS27645 HMPREF2590_RS206101-palmitoyl- 7,10,13,16,19-pentaenoyl-[acp] L-histidine a 2'- HMPREF2590_RS16180 1-palmitoyl-2- HMPREF2590_RS23435 [+ 3 isozymes] ribofuranosyl) 5-phosphate NAD + HMPREF2590_RS11695 HMPREF2590_RS05395 dipalmitoyl 3'-cmp HMPREF2590_RS18485 Cys an L-glutaminyl- HMPREF2590_RS05310 L-threonine 3- DMKH 5-aminolevulinate nicotinamide reductoisomerase: D-glyceraldehyde superpathway of heme dihydrofolate reductase: methionine synthase: [tRNA ] acyl-carrier protein palmitoleoyl-sn- acyl-carrier protein 2 acyl-carrier protein sn-glycerol deoxyribonucleoside cis-vaccenoyl 3'-AMP pyruvate 3-methyl-2- uroporphyrinogen-III Gln arylformamidase: phosphatidate asp uroporphyrinogen-III 4-phosphooxy- molybdopterin HMPREF2590_RS03175 [+ 2 isozymes] a tRNA Cys [tRNA ] L-glutamate-5- dehydrogenase: 5'-diphosphate phosphatidate HMPREF2590_RS04950 a reduced 3-phosphate b biosynthesis from oxobutanoate uroporphyrinogen HMPREF2590_RS07115 (lipoyl)adenylate lipid II (meso an (S-diacyl-sn- HMPREF2590_RS15050 glycerol 3-phosphate 3-phosphate 1-deoxy-D- uroporphyrinogen-III L-threonine a lipoprotein HMPREF2590_RS25565 H O c-type 1-deoxy-D-xylulose-5- uroporphyrinogen-III dihydrofolate reductase: glyceryl)-L-cysteinyl- semialdehyde L-2-amino-3- xylulose 5- 2 L-aspartate oxidase: C-methyltransferase: 3-methyl-2-oxobutanoate decarboxylase: diaminopimelate signal peptide cytochrome cytochrome phosphate synthase: HMPREF2590_RS25425 lipoate--protein ligase A: [apolipoprotein] oxobutanoate phosphate an oxidized HMPREF2590_RS09345 HMPREF2590_RS00195 uroporphyrinogen-III hydroxymethyltransferase: HMPREF2590_RS11605 containing) L-glutamate gamma- L-kynurenine c oxidase HMPREF2590_RS11695 O c-type 2-iminosuccinate HMPREF2590_RS06755 NUDIX hydrolase: uroporphyrinogen HMPREF2590_RS17115 coproporphyrinogen III semialdehyde 2 uroporphyrinogen-III molybdopterin a [glycine- arsenite RS28180 arsenitecytochrome 1-deoxy-D- 3-amino-1- NAD+ synthetase, HMPREF2590_RS20715 decarboxylase: L-asparagine biosynthesis dehydrogenase: kynureninase: 1-palmitoyl- all-trans- (25S)-3- uridine 2'3'-cyclic an organic quinolinate synthase NadA: C-methyltransferase: adenine dinucleotide 2-dehydropantoate cleavage complex gln a 2,3,4-saturated a 2,3,4-saturated 2- a cis- 2-carboxy-1,4- sn-glycerol a tripeptide a ribonucleoside formate CTP xylulose 5- hydroxyacetone glutamine dependent: HMPREF2590_RS11605 serine III (tRNA-dependent) an N-acyl-(S-diacyl- HMPREF2590_RS28215 HMPREF2590_RS15045 sn-glycerol tridecaprenyl a stearoyl-[acp] oxocholest- coenzyme A GGPP IPP monophosphate thr hydroperoxide HMPREF2590_RS16540 6 fatty acyl-[acp] lysophosphatidate vaccenoyl-[acp] naphthoquinol 3-phosphate triphosphate AMP HMPREF2590_RS09355 phosphate 1-phosphate HMPREF2590_RS10235 coproporphyrinogen III molybdopterin H protein] N - an L-glutaminyl- a peptide 3-phosphate diphosphate peptidase T: 4-en-26-oate bifunctional 2',3'- alkylhydroperoxidase: precorrin-1 nicotinate adenine 2-dehydropantoate a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate sn-glyceryl)-L- aminoacetone 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate glycerol-3-phosphate acyl-CoA synthetase: anaerobic ribonucleoside- anaerobic ribonucleoside- heptaprenyl NMN Gln bifunctional threonine bifunctional dinucleotide molybdenumtransferase lipoyl-L-lysine [tRNA ] cysteinyl-[lipoprotein] glu anthranilate phosphate acyltransferase: phosphate acyltransferase: acyltransferase: HMPREF2590_RS29335 HMPREF2590_RS20730 triphosphate reductase: triphosphate reductase: diphosphate synthase: cyclic-nucleotide 2'- HMPREF2590_RS16225 a cation a cation quinolinate 2-reductase: protoporphyrinogen IX HMPREF2590_RS26220 asp L-serine degradation polyprenyltransferase: ammonia-lyase/L-serine MoeA: a tRNA Gln HMPREF2590_RS03160 HMPREF2590_RS20605 phosphodiesterase/ alkyl hydroperoxide metallophosphatase/ uroporphyrinogen-III HMPREF2590_RS09675 aspartate-- HMPREF2590_RS03160 HMPREF2590_RS27645 HMPREF2590_RS08825 peptidase T: acyl-CoA synthetase: HMPREF2590_RS20605 HMPREF2590_RS16975 ammonia-lyase TdcB: RS21945 HMPREF2590_RS20415 L-methionine degradation II 3'-nucleotidase: reductase subunit F: 5'-nucleotidase: nicotinate-nucleotide C-methyltransferase: nicotinate-nicotinamide protoporphyrinogen thymidylate synthase: tRNA(Asn) ligase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1,4-dihydroxy-2-naphthoate glycerol-3-phosphate HMPREF2590_RS04555 (25S)-3- HMPREF2590_RS10160 anaerobic ribonucleoside- anaerobic ribonucleoside- heptaprenyl diphosphate HMPREF2590_RS23035 ala ala [+ 2 isozymes] 2-dehydropantoate a [lipoyl-carrier a proteinogenic HMPREF2590_RS06475 HMPREF2590_RS28030 HMPREF2590_RS06365 diphosphorylase HMPREF2590_RS00195 pyridoxine nucleotide oxidase: HMPREF2590_RS03180 HMPREF2590_RS03290 ser phosphate acyltransferase: phosphate acyltransferase: polyprenyltransferase: acyltransferase: a dipeptide oxocholest-4- triphosphate reductase: triphosphate reductase: synthase component II: a cation RS09660 a cation protoporphyrinogen IX 2-reductase: heme b biosynthesis 6 an L-aspartyl- methylglyoxal [+ 3 isozymes] [+ 2 isozymes] (carboxylating): uroporphyrinogen-III 5'-phosphate MoO -molybdopterin HMPREF2590_RS02400 bifunctional a (6S)-5- protein]-N - 5-oxo-L-proline metabolism serine dehydratase: HMPREF2590_RS23435 HMPREF2590_RS23435 HMPREF2590_RS20610 amino acid en-26-oyl-CoA HMPREF2590_RS03520 HMPREF2590_RS03520 HMPREF2590_RS16985 [+ 3 isozymes] an alcohol adenylyltransferase: 2 HMPREF2590_RS05445 Asn met a 2,3,4-saturated 1-palmitoyl-2- HMPREF2590_RS18215 1-stearoyl- a 2'- all-trans- 2-oxobutanoate II (anaerobic) lipoyl-L-lysine [tRNA ] D-serine degradation 3'-UMP adenosine HMPREF2590_RS09350 C-methyltransferase: HMPREF2590_RS07505 protoporphyrinogen cofactor protoporphyrinogen methylenetetrahydrofolate formyltetrahydrofolate HMPREF2590_RS24025 acyl-carrier protein acyl-carrier protein cis-vaccenoyl DMKH2-13 acyl-carrier protein sn-glycerol deoxyribonucleoside dCTP heptaprenyl β-alanine glu an N-terminal methionine gamma-lyase: 1,2-diacyl-sn- HMPREF2590_RS16540 oxidase: (R)-pantoate dehydrogenase/ Asp-tRNA(Asn) an N-terminal L- [+ 3 isozymes] NaMN oxidase: uroporphyrinogen-III 5-formyltetrahydrofolate L-glutaminyl- 2-aminoprop- HMPREF2590_RS11325 glycerol 3-phosphate phosphatidate 3-phosphate 5'-triphosphate diphosphate a cation RS17480 a cation HMPREF2590_RS02400 methenyltetrahydrofolate /Glu-tRNA(Gln) glutamyl-[protein] (2Z)-2-aminobut- D-serine precorrin-2 HMPREF2590_RS11615 uroporphyrinogen cyclo-ligase: an L-glutamyl- [protein] 2-enoate NaMN nicotinamide cyclohydrolase: Glu amidotransferase Fermentation 2-enoate nicotinate-nicotinamide PLP protoporphyrinogen decarboxylase: HMPREF2590_RS07175 [tRNA ] D-serine ammonia-lyase: pantoate--beta- protoporphyrin IX glu 1-stearoyl- all-trans- (R)-4'- 1915 1-oleoyl-sn nicotinate oxidase: HMPREF2590_RS06775 a tRNA subunit GatA: gatA a (7Z)-hexadec- 2-carboxy-1,4- sn-glycero-3- a pseudouridine a ribonucleoside UDP nucleotide precorrin-2 heme a biosynthesis alanine ligase: HMPREF2590_RS11605 a 5,10- a 5,10- HMPREF2590_RS18075 an oleoyl-[acp] sn-glycerol a malonyl-[acp] decaprenyl phosphopantothenoyl- H O diphosphate formate UTP -glycerol 3- acetyl-CoA S-adenosyl-L-methionine cycle I phosphoribosyltransferase: HMPREF2590_RS11615 an L-asparaginyl- pyruvate fermentation 2-aminoprop- 7-enoyl-[acp] naphthoquinol phosphoethanolamine in 23S rRNA 2 5'-monophosphate ribonucleotide-diphosphate dITP a cation RS02835 a cation adenylyltransferase: dehydrogenase: HMPREF2590_RS17120 ferrochelatase: coproporphyrinogen III methylenetetrahydrofolate methenyltetrahydrofolate L-glutamate degradation II 3-phosphate diphosphate L-cysteine glycerophosphodiester 23S rRNA phosphate acetyl-CoA carboxylase lipoate biosynthesis and Asn 2-enoate 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- 1,4-dihydroxy-2-naphthoate manganese- anaerobic ribonucleoside- bifunctional HMPREF2590_RS07505 HMPREF2590_RS16550 HMPREF2590_RS11525 [tRNA ] a [protein] with to (R)-acetoin II bifunctional 1-acyl-sn-glycerol-3- reductase subunit beta: XTP/dITP diphosphatase: HMPREF2590_RS11610 bifunctional incorporation III (Bacillus) 2-iminopropanoate protein] synthase II: phosphodiesterase: (pseudouridine(1915)-N(3) dependent inorganic triphosphate reductase: biotin carboxyl: nicotinate protoporphyrin IX ferroheme b an N-terminal 5- 2-iminobutanoate phosphate acyltransferase: polyprenyltransferase: phosphopantothenoylcysteine phosphate acyltransferase: metallophosphatase/ HMPREF2590_RS16175 nicotinate adenine ferrochelatase: methylenetetrahydrofolate γ-L-glutamyl HMPREF2590_RS19630 )-methyltransferase RlmH: pyrophosphatase: HMPREF2590_RS13535 HMPREF2590_RS09090 sirohydrochlorin SAM phosphoribosyltransferase: protoheme IX (R)-pantothenate isoleucine--tRNA ligase: pyruvate glu L-threonine degradation II HMPREF2590_RS03160 HMPREF2590_RS12485 HMPREF2590_RS27645 decarboxylase/ HMPREF2590_RS20605 HMPREF2590_RS03160 5'-nucleotidase: dinucleotide ferrochelatase: HMPREF2590_RS11955 dehydrogenase/ oxo-L-proline 5-phosphate glutathione HMPREF2590_RS26915 ribonucleoside- HMPREF2590_RS13540 nucleoside triphosphate a cation a cation farnesyltransferase: an octanoyl-[acp] 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- [+ 4 isozymes] an N 3 - HMPREF2590_RS14720 anaerobic ribonucleoside- HMPREF2590_RS21560 HMPREF2590_RS25675 thiamine diphosphate HMPREF2590_RS03305 acetolactate synthase: aspartate transaminase: 1,4-dihydroxy-2-naphthoate phosphopantothenate-- 1-acyl-sn-glycerol-3- diphosphate reductase: RS21950 NAD+ synthetase, sirohydrochlorin HMPREF2590_RS11610 methenyltetrahydrofolate ile sn-glycerol 1915 [+ 3 isozymes] pyrophosphohydrolase: NAD(+) synthetase: HMPREF2590_RS05570 pantothenate kinase: ferroheme b protoporphyrinogen IX octanoyltransferase LipM: isoleucine--tRNA ligase: pyroglutamyl-peptidase I: HMPREF2590_RS16395 2-iminopropanoate phosphate acyltransferase: protein] synthase II: polyprenyltransferase: cysteine ligase CoaBC: ethanolamine methylpseudouridine pyrophosphatase PpaX: triphosphate reductase: phosphate acyltransferase: [+ 2 isozymes] HMPREF2590_RS16180 glutamine dependent: ferrochelatase: S-adenosylmethionine ferrochelatase: biosynthesis III (Staphylococcus) cyclohydrolase: HMPREF2590_RS17145 3-phosphate HMPREF2590_RS08095 ala ala HMPREF2590_RS10235 ferroheme o HMPREF2590_RS08035 HMPREF2590_RS05320 HMPREF2590_RS01595 HMPREF2590_RS16400 pyruvate thr HMPREF2590_RS23435 HMPREF2590_RS12060 HMPREF2590_RS18215 HMPREF2590_RS05195 in 23S rRNA HMPREF2590_RS22285 HMPREF2590_RS03520 a ribonucleoside malonyl-CoA HMPREF2590_RS10235 HMPREF2590_RS16545 synthase: nicotinate 2-(2-carboxy-4- HMPREF2590_RS06775 a [glycine-cleavageHMPREF2590_RS06915 an L-isoleucyl- asp 1-stearoyl-2- a (9Z)-3-oxo- HMPREF2590_RS23435 dUDP a cation a cation HMPREF2590_RS11955 2-oxobutanoate L-threonine 3- + dUTP dioleoyl dIMP (R)-4'- [tRNA Ile ] [+ 2 isozymes] acyl-carrier protein oleoyl-sn-glycerol acyl-carrier protein octadec-9- DMKH2-10 4'-phosphopantetheine phosphate H HMPREF2590_RS27190 HMP-PP methylthiazol-5- 10 complex H protein] RS02035 heme A synthase: an N - Ile dehydrogenase: phosphatidate NAD + siroheme ferroheme b phosphopantothenate 6 a tRNA (S)-2-acetolactate 3-phosphate enoyl-[acp] HMPREF2590_RS05575 yl)ethylthiamine phosphate phosphate formyltetrahydrofolate N -octanoyl-L-lysine 5-oxo-L-proline aspartate ammonia- HMPREF2590_RS25565 ala ala GcvH:[lipoyl domain] L-2-amino-3- di-trans,poly-cis-undecaprenyl protoporphyrin IX synthase: acetolactate lyase: aspA pyruvate a cation RS27050 a cation met SAH oxobutanoate ferroheme i HMPREF2590_RS27815 amidotransferase: decarboxylase: aspartate ammonia-lyase: α-D- 5'-methylthioadenosine/ thiamine diphosphate phosphate biosynthesis a lipid II a (3Z)-dec- ditrans,octacis- S-methyl-L- uroporphyrinogen-III a 3-oxopimeloyl- dCDP ferrochelatase: HMPREF2590_RS26575 HMPREF2590_RS24280 2-amino-3-ketobutyrate a malonyl-[acp] L-homocysteine 3'-dephospho- glucopyranose CTP phosphoenol L-homoserine S-adenosylhomocysteine thiamine phosphate HMPREF2590_RS25620 undecaprenyldiphospho- ATP ATP H O dADP XTP biosynthesis I (E. coli) HMPREF2590_RS11610 D-Ala-D-Ala 3-enoyl-[acp] methionine 2 [acp] methyl ester ribonucleotide-diphosphate 5-methyltetrahydropteroyltriglutamate- heme A synthase: (2E,6E)-farnesyl a [lipoyl-carrier protein] CoA ligase: beta-ketoacyl-[acyl-carrier- N-acetyl-(N- CoA 1-phosphate pyruvate uroporphyrinogen-III nucleosidase: bis(guanylyl molybdenum IPP synthase: leu bifunctional homocysteine ATPase: glucose-1-phosphate pyruvate kinase: 3-oxoacyl-[acyl-carrier- reductase subunit beta: HMPREF2590_RS05575 diphosphate ferrochelatase: 6 leucine--tRNA ligase: glu (R)-acetoin fumarate HMPREF2590_RS25570 carboxypeptidase VanY: dephospho-CoA kinase: C-methyltransferase: homoserine O- XTP/dITP diphosphatase: a cation RS21875 a cation - homocysteine S-methyltransferase: di-trans,poly-cis-decaprenyl HMPREF2590_RS24990 N -octanoyl-L-lysine protein] synthase II: acetylglucosaminyl) S-methyltransferase/ protein] reductase: HMPREF2590_RS07710 HMP-PP cofactor) biosynthesis HMPREF2590_RS11955 thiamine L-phenylalanine degradation I (aerobic) HMPREF2590_RS18670 HMPREF2590_RS23085 cytidylyltransferase: HMPREF2590_RS18845 HMPREF2590_RS16175 succinyltransferase: HMPREF2590_RS09090 HMPREF2590_RS05860 HMPREF2590_RS27040 an L-leucyl- L-asparagine HMPREF2590_RS12485 muramoyl-L-alanyl- methylenetetrahydrofolate HMPREF2590_RS10980 HMPREF2590_RS16540 HMPREF2590_RS05100 folate polyglutamylation [+ 4 isozymes] thiamine phosphate MoO - hydroxyferroheme i diphosphate:isopentenyl- phosphate lipoyl synthase: gly [+ 3 isozymes] HMPREF2590_RS19020 ribonucleoside- HMPREF2590_RS26670 2 Leu D-Ala-D-Ala γ pyruvate kinase: nucleoside triphosphate methionine synthase: [tRNA ] degradation I -D-isoglutaminyl- reductase: + uroporphyrinogen-III [+ 7 isozymes] synthase: diphosphate ferroheme b HMPREF2590_RS21540 beta-ketoacyl-[acyl-carrier- ADP coenzyme A H + a (3R)-3- molybdopterin a tRNA Leu (6R)-4a-hydroxy- carboxypeptidase VanY: H phosphate ADP glucose-1-phosphate HMPREF2590_RS11050 diphosphate reductase: O-succinyl-L- pyrophosphohydrolase: HMPREF2590_RS07115 L-homocysteine S-ribosyl-L-homocysteine HMPREF2590_RS27815 undecaprenylcistransferase: a [lipoyl-carrier Aldehyde Degradation protein] synthase II: N-(β-D-asparaginyl)peptidoglycan HMPREF2590_RS07125 C-methyltransferase: a cation RS21090 a cation cofactor bis(molybdenum tetrahydrobiopterin 4a-hydroxytetrahydrobiopterin HMPREF2590_RS27595 cytidylyltransferase: hydroxypimeloyl- HMPREF2590_RS16180 homoserine HMPREF2590_RS08095 a tetrahydrofolate thioredoxin pathway 6 di-trans,octa-cis-L-lysyl-D-alanineatransglycosylase: peptidoglycan dATP pyruvate HMPREF2590_RS00195 di-trans,octa-cisHMPREF2590_RS04960 protein]-N -[(R)- 6 37 asn HMPREF2590_RS12060 [acp] methyl ester thiamine phosphate cofactor) synthase: N -L-threonylcarbamoyladenosine dehydratase: a N-acetylglucosamine--N- a (5Z)-3- met HMPREF2590_RS19730 CDP dihydrolipoyl]-L-lysine phenylalanine 4- asparaginase: -undecaprenyl dimerHMPREF2590_RS25965 (E. faecium precorrin-2 XMP synthase: HMPREF2590_RS27165 -undecaprenyl NAD phosphorylation and dephosphorylation -modified tRNA biosynthesis HMPREF2590_RS07635 methylglyoxal degradation I D-ala acetylmuramyl-(tetrapeptide) acyl-carrier protein oxododec- CDP-α-D-glucose bis(molybdenum ferroheme a thiamine monooxygenase: HMPREF2590_RS01900 diphosphate , tetrapeptide) formate-- bifunctional serine HMPREF2590_RS24990 an oxidized diphosphate L-glutamine degradation I pyrophosphoryl-undecaprenol 5-enoyl-[acp] a cation RS26755 a cation tetrahydrofolate ligase: folylpolyglutamate synthase/ hydroxymethyltransferase: thiamine cofactor) thioredoxin undecaprenyl- lipoate biosynthesis HMPREF2590_RS07630 asparaginase: S-ribosylhomocysteine lyase: thiamine diphosphokinase: + val thr methylglyoxal HMPREF2590_RS00355 dihydrofolate synthase: HMPREF2590_RS26220 phosphate molybdenum cofactor diphosphate phosphatase: and incorporation I NAD valine--tRNA ligase: HMPREF2590_RS16885 HMPREF2590_RS27320 HMPREF2590_RS05145 threonylcarbamoyl- (6R)-L-erythro-5,6,7,8- L-erythro-7,8- lactoylglutathione lyase: 1-stearoyl- 5-amino-4- 6-cis, 3-oxo- a 2'- an [amino group carrier a [lipoyl-carrier an oxidized HMPREF2590_RS09210 guanylyltransferase: HMPREF2590_RS16320 guanylyl molybdenum HMPREF2590_RS09205 an L-valyl- L-alanine degradation IV asp gln an acyl-[acyl- a (5Z)-tetradec- PRPP oleate a uridine in tRNA a 3-oxoglutaryl- tetrahydrobiopterin dihydrobiopterin sn-glycerol a malonyl-[acp] deoxyribonucleoside [DNA] protein]-C-terminal-γ- phosphoenol protein]-N 6 -[(R) nitroaromatic 10 HMPREF2590_RS27165 an octanoyl-[acp] Val AMP synthase: HMPREF2590_RS24620 imidazolecarboxyamide tridecenoyl-CoA a cation RS17935 a cation an N - a 5,10- thioredoxin- [+ 4 isozymes] thiamine cofactor biosynthesis [tRNA ] CTP synthase: (R)-S- carrier protein] 5-enoyl-[acp] dGDP [acp] methyl ester IMP bis(guanylyl Val HMPREF2590_RS26265 3-phosphate1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- adenine long-chain fatty acetyl-CoA C- 5'-triphosphate (L-glutamyl)-L-glutamate pyruvate tRNA-dihydrouridine 3-oxoacyl-[acyl-carrier- -dihydrolipoyl]- compound formyltetrahydrofolate methylenetetrahydrofolate disulfide reductase: diphosphate NAD kinase: MoO - a tRNA (L-threonylcarbamoyl) HMPREF2590_RS02365 DNA polymerase acetylglutamate kinase: pyruvate kinase: di-trans,octa-cis- octanoyltransferase LipM: 2 lactoylglutathione acid--CoA ligase: acyltransferase: synthase: bifunctional a tetrahydrofolate thiamine molybdopterin alkaline phosphatase: HMPREF2590_RS04355 ala [+ 13 isozymes] phosphate acyltransferase: protein] synthase II: phosphoribosyltransferase: III subunit delta: protein] reductase: L-lysine dihydrolipoyl NAD(P)H nitroreductase: bifunctional bifunctional lipoate biosynthesis HMPREF2590_RS22270 undecaprenyl phosphate HMPREF2590_RS06915 molybdopterin adenylate HMPREF2590_RS14750 HMPREF2590_RS18845 metallophosphatase/ diphosphate cofactor) a [lipoyl-carrier protein] HMPREF2590_RS07575 HMPREF2590_RS23435 HMPREF2590_RS12485 HMPREF2590_RS07885 HMPREF2590_RS08940 HMPREF2590_RS21680 HMPREF2590_RS07460 HMPREF2590_RS28085 HMPREF2590_RS05100 dehydrogenase: HMPREF2590_RS03085 folylpolyglutamate synthase/ folylpolyglutamate synthase/ and incorporation II NAD kinase: cofactor molybdopterin- N 6 -L- alanine dehydrogenase: glu acetylglutamate kinase: pyruvate kinase: 5'-nucleotidase: a cation a cation N 6 -octanoyl-L-lysine [+ 2 isozymes] adenine/guanine [+ 5 isozymes] [+ 2 isozymes] tRNA dihydrouridine HMPREF2590_RS14960 a reduced dihydrofolate synthase: dihydrofolate synthase: HMPREF2590_RS11265 guanine dinucleotide threonylcarbamoyladenine HMPREF2590_RS11175 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- [+ 8 isozymes] an [amino group HMPREF2590_RS06510carrier HMPREF2590_RS11050 a (3R)-3-[+ 7 isozymes] HMPREF2590_RS06365 RS25485 phosphoribosyltransferase: acetyl-CoA 4-cis- synthase DusB: a [lipoyl-carrier octanoate a reduced lipoyl synthase: [+ 2 isozymes] phosphate acyltransferase: protein] synthase II: [DNA] protein]-C-terminal- hydroxyglutaryl- [+ 2 isozymes] nitroaromatic HMPREF2590_RS09210 HMPREF2590_RS09210 demethylmenaquinol- base-degraded thiamine salvage biosynthesis protein B: synthase: (R)-lactate diphosphate AMP oleoyl-CoA undecenoyl-CoA dGTP pyruvate 6 [+ 2 isozymes] ala ala ala pyruvate HMPREF2590_RS03160 HMPREF2590_RS12060 HMPREF2590_RS21450 γ HMPREF2590_RS07985 protein]-N - compound an N 10 - a 5,10- lipoate--protein ligase A: 8 biosynthesis I thioredoxin HMPREF2590_RS21540 HMPREF2590_RS12340 alanine--tRNA ligase: HMPREF2590_RS26090 a 1-stearoyl 2- a (7Z)-3-oxo- -(5-phospho-L- a 5,6-dihydrouridine [acp] methyl ester a cation RS07895 a cation demethylmenaquinol-6 biosynthesis I demethylmenaquinol-9 biosynthesis 6 lipoyl-L-lysine inosine HMPREF2590_RS11695 a [lipoyl-carrier formylaminopyrimidine + an N -L- acyl-carrier protein acyl-sn-glycerol acyl-carrier protein hexadec-7- AICAR glutamyl)-L-glutamate formyltetrahydrofolate methylenetetrahydrofolate 2-carboxy-1,4- NADP molybdenum cofactor HMPREF2590_RS07785 an L-alanyl- in tRNA a [lipoyl-carrier protein] protein]-N 6 -[(R)- threonylcarbamoyladenine 37 all-trans- all-trans- guanylyltransferase: [tRNA Ala ] Glycolysis 3-phosphate enoyl-[acp] N 6 -octanoyl-L-lysine naphthoquinol 2-carboxy-1,4- 2-carboxy-1,4- 1,4-dihydroxy-2-naphthoate hexaprenyl nonaprenyl dihydrolipoyl]-L-lysine guanylyl HMPREF2590_RS27165 a tRNA Ala in tRNA naphthoquinol naphthoquinol aminomethylpyrimidine a cation a cation lipoyl synthase: polyprenyltransferase: diphosphate 1,4-dihydroxy-2-naphthoate diphosphate 1,4-dihydroxy-2-naphthoate molybdenum pyruvate DNA with adenine:7,8- menaquinol-9 biosynthesis glycolysis I (from glucose 6-phosphate) Inorganic Nutrient Metabolism 1-myristoyl- ditrans,octacis- ditrans,octacis- 6-trans-3-oxo- RS21890 HMPREF2590_RS21540 HMPREF2590_RS27645 polyprenyltransferase: polyprenyltransferase: thiaminase II: cofactor a (4Z)-hexadec- a 3-oxohexacosanoyl- a 3-oxoicosanoyl- NaMN a phosphate acyl carrier protein activation glutathionylspermidine menaquinol-6 biosynthesis a myristoyl-[acp] sn-glycerol undecaprenyldiphospho- undecaprenyldiphospho- a malonyl-[acp] tridecenoyl-CoA dihydro-8- acyl-carrier protein L-homocysteine a [lipoyl-carrier 4-enoyl-[acp] [acp] [acp] monoester ITP ala ala biosynthesis 1,4-dihydroxy-2-naphthoate HMPREF2590_RS27645 HMPREF2590_RS27645 HMPREF2590_RS13865 3-phosphate acetyl-CoA C- oxoguanine mismatch bifunctional 6 demethylmenaquinol-9 1-acyl-sn-glycerol-3- N-acetyl-(N- N-acetyl-(N- 3-oxoacyl-[acyl-carrier- A/G-specific adenine ACP S-malonyltransferase: 3-oxoacyl-[acyl-carrier- bifunctional homocysteine 3-oxoacyl-[acyl-carrier- alkaline phosphatase: 2+ 2+ protein]-N -[(R)- polyprenyltransferase: menaquinol-8 biosynthesis thiaminase II: Activation/Inactivation/ D-glucopyranose 6-phosphate selenate reduction acyltransferase: XTP/dITP diphosphatase: Co RS18755 Co an apo acyl- 1,4-dihydroxy-2-naphthoate demethylmenaquinone 1,4-dihydroxy-2-naphthoate 2-aminoethylphosphonate phosphate acyltransferase: acetylglucosaminyl) acetylglucosaminyl) protein] reductase: glycosylase: HMPREF2590_RS12450 protein] reductase: S-methyltransferase/ protein] reductase: metallophosphatase/ HMPREF2590_RS07575 coenzyme A demethylmenaquinol-6 dihydrolipoyl]-L-lysine asn Interconversion HMPREF2590_RS09090 glutathione spermidine HMPREF2590_RS18215 polyprenyltransferase: polyprenyltransferase: HMPREF2590_RS25010 degradation I HMPREF2590_RS03160 γ muramoyl-L-alanyl-γ-D- HMPREF2590_RS05100 HMPREF2590_RS21680 HMPREF2590_RS00915 HMPREF2590_RS05100 5'-nucleotidase: carrier4'-phosphopantetheinyl protein demethylmenaquinone methyltransferase: asparagine--tRNA ligase: muramoyl-L-alanyl- - ACP S-malonyltransferase: methylenetetrahydrofolate HMPREF2590_RS05100 alkaline phosphatase: glutathionylspermidine demethylmenaquinol-8 HMPREF2590_RS18215 HMPREF2590_RS18215 demethylmenaquinol-8 glucose-6-phosphate selenate urea cycle β [+ 2 isozymes] HMPREF2590_RS21560 nucleoside triphosphate methyltransferase: HMPREF2590_RS16980 4-amino-2-methyl-5- HMPREF2590_RS10855 an L-asparaginyl- oleandomycin (2-aminoethyl) 1-acyl-sn-glycerol-3- D-isoglutaminyl-N-( - isoglutaminyl-L-lysyl-peptidoglycan [+ 2 isozymes]a (6Z)-3- an apurinic site HMPREF2590_RS12625 a (3R)-3-[+ 7 isozymes] reductase: a (3R)-3-[+ 7 isozymes] HMPREF2590_RS01160 transferase: synthase: demethylmenaquinol-6 demethylmenaquinol-9 demethylmenaquinone Carbohydrate Biosynthesis isomerase: 4-trans- adenine pyrophosphohydrolase: acetate acetate HMPREF2590_RS16980 menaquinol-9 pyrimidinemethanol [tRNA Asn ] activation/inactivation sulfate adenylyltransferase: phosphate acyltransferase: D-asparaginyl)-L-lysyl-peptidoglycan (glycyl) -D-alanyl-D-alanine acetyl-CoA within DNA HMPREF2590_RS07125 [+ 2 isozymes] HMPREF2590_RS24095 HMPREF2590_RS21125 phosphonate 5 di-trans,octa-cistransglycosylase: acyl-carrier protein oxooctadec- undecenoyl-CoA a malonyl-[acp] hydroxyhexacosanoyl- hydroxyicosanoyl- β-D- an alcohol HMPREF2590_RS14225 methyltransferase: Asn HMPREF2590_RS16520 2-aminoethylphosphonate- di-trans,octa-cisD-alanyl-D-alanine a peptidoglycan HMPREF2590_RS08095 RS17465 menaquinol-6 tRNA 1,2-dimyristoyl-HMPREF2590_RS23435 atransglycosylase: peptidoglycan HMPREF2590_RS25965-undecaprenyl 6-enoyl-[acp] [acp] met [acp] [+ 3 isozymes] glutathionylspermidine HMPREF2590_RS16980 gluconeogenesis I adenosine 5'- arg -pyruvate transaminase: ribosylnicotinate IMP a holo acyl- UDP-N-acetyl-D- oleandomycin -undecaprenyl HMPREF2590_RS25965 dimer (S. aureus) a cation a cation 3',5'-ADP menaquinol-8 dTDP-L-rhamnose F6P phosphoselenate arginase: HMPREF2590_RS16030 acyl-carrier protein sn-glycerol dimer (E. faeciums) diphosphate ornithine ornithine carrier protein glucosamine biosynthesis I Oleandomycin diphosphate biosynthesis I HMPREF2590_RS23635 phosphonoacetaldehyde 3-phosphate RS27870 (S)-malate glycosyltransferase: argininosuccinate lyase: D-glucopyranose α-D- aspartate--tRNA ligase: HMPREF2590_RS10595 phosphonoacetaldehyde arg arg 6-phosphate glucosyl- 6-phosphofructokinase: HMPREF2590_RS20330 ornithine ornithine glucopyranose a (2R)-2-hydroxy an odd numbered an N-formyl-L- 3-oxo-(7Z)- adenine 1518 / a dipetide with an N- a 3- a (7Z)-3- an [RNA]-3'- glucose-6-phosphate HMPREF2590_RS07860 oleandomycin HMPREF2590_RS11055 argininosuccinate lyase: hydrolase: linoleate a 3-oxotetracosanoyl- histidinol 1-phosphate selenite ammonium even numbered straight chain methionylaminoacyl- 1519 oxodocosanoyl- oxohexacos- ribonucleoside- met RS24375 isomerase: glucose-1-phosphate aspartate-- HMPREF2590_RS16025 tetradecenoyl-CoA adenine in 16S rRNA terminal L-aspartate [acp] Fatty Acid and Lipid Biosynthesis malate dehydrogenase: asp HMPREF2590_RS11200 straight chain 2,3,4- 2,3,4-saturated long-chain fatty tRNA acetyl-CoA C- [acp] 2',3'- malate dehydrogenase: HMPREF2590_RS21125 thymidylyltransferase: tRNA(Asn) ligase: peptide deformylase: ribosomal RNA small peptidase E: 3-oxoacyl-[acyl-carrier- 3-oxoacyl-[acyl-carrier- 7-enoyl-[acp]3-oxoacyl-[acyl-carrier- bifunctional glutamate arg arg HMPREF2590_RS11015 carbamoyl- acetaldehyde saturated fatty acidlong-chain fatty fatty acid long-chain fatty acid--CoA ligase: acyltransferase: cyclophosphate histidinol dehydrogenase: HMPREF2590_RS09370 F6P HMPREF2590_RS22825 HMPREF2590_RS03290 DHAP β-D-fructose 1,6-bisphosphate L-arginino- HMPREF2590_RS05185 subunit methyltransferase HMPREF2590_RS18025 protein] reductase: protein] reductase: protein] reductase: RNA 2',3'-cyclic N-acetyltransferase/ ornithine ornithine an L-aspartyl- phosphate synthase: acid--CoA ligase: acid--CoA ligase: HMPREF2590_RS16440 palmitate biosynthesis II (bacteria and plants) L-ornithine HMPREF2590_RS08940 HMPREF2590_RS26370 A: HMPREF2590_RS08170 dipeptidase PepV: HMPREF2590_RS05100 HMPREF2590_RS05100 HMPREF2590_RS05100 RS25525 palmitoleate biosynthesis I gondoate biosynthesis (anaerobic) sphingomyelin metabolism glucose-1-phosphate [tRNA asp ] glucosyl- succinate peptide deformylase: phosphodiesterase: amino-acid L-glutamine--D- HMPREF2590_RS05275 HMPREF2590_RS08940 HMPREF2590_RS08940 [+ 5 isozymes] [+ 2 isozymes] N 6 -dimethyladenine 1518 HMPREF2590_RS12255 (from (5Z)-dodec-5-enoate) thymidylyltransferase: tRNA asp oleandomycin fructose-1,6-bisphosphate HMPREF2590_RS05715 a (3R)-3-[+ 7 isozymes] a (3R)-3-[+ 7 isozymes] a (3R,7Z)-3-[+ 7 isozymes] HMPREF2590_RS12250 acetyltransferase ArgJ: arg arg selenodiglutathione HMPREF2590_RS05280 a[+ ( R5)-2-hydroxy isozymes] even an odd numbered (5Z)- 6 1519 an [RNA]-3'- oxaloacetate pyruvate fructose-6-phosphate triose-phosphate [+ 5 isozymes] a L-methionylaminoacyl- acetyl-CoA /N -dimethyladenine a proteinogenic his HMPREF2590_RS06515 glycine glycine an acetoacetyl-[acp] an N-acyl- HMPREF2590_RS12490 aldolase, class II: numbered straight straight chain diphosphate formate dodecenoyl-CoA asp hydroxytetracosanoyl- hydroxydocosanoyl- hydroxyhexacos- ribunucleoside- RS14885 Secondary Metabolite Biosynthesis aminotransferase: dTDP-α-D-glucose carbamoyl diphosphate AMP diphosphate AMP AMP linoleoyl-CoA tRNA in 16S rRNA amino acid N-acetyl-L- betaine betaine a (5Z)-dodec- a malonyl-[acp] an oleoyl-[acp] sphingosylphosphorylcholine isomerase: HMPREF2590_RS26320 chain 2,3,4-saturated 2,3,4-saturated [acp] [acp] 7-enoyl-[acp] HMPREF2590_RS23610 phosphate acetyl-CoA 2'-phosphate methionine 5-enoyl-[acp] beta-ketoacyl-[acyl-carrier- phosphoenolpyruvate phosphoenolpyruvate dTDP-glucose HMPREF2590_RS22160 ornithine fatty acyl CoA fatty acyl CoA 3-oxoacyl-[acyl-carrier- beta-ketoacyl-[acyl-carrier- D-glucosamine protein] synthase II: sphingomyelin hopanoid biosynthesis (bacteria) carboxykinase (ATP): synthase: 4,6-dehydratase: tyrosine--tRNA ligase: carbamoyltransferase: protein] reductase: protein] synthase II: autoinducer AI-2 biosynthesis I 6-phosphate oleandomycin argininosuccinate synthase: HMPREF2590_RS12485 HMPREF2590_RS27195 HMPREF2590_RS01705 glutathioselenol glycine glycine HMPREF2590_RS05100 HMPREF2590_RS12485 phosphodiesterase: HMPREF2590_RS22815 HMPREF2590_RS11380 HMPREF2590_RS27875 a 2-methyl RS14895 (2E,6E)-farnesyl phosphoglucosamine tyr D-glyceraldehyde 3-phosphate HMPREF2590_RS11205 undecaprenyl-diphospho-N α,ω-9Z- salicyl-6-hydroxy-2- 3-oxo-(11Z)- 4-(cytidine 5'- a 3- a (5Z)-3- an (11Z)-3- a [protein]-L- betaine betaine [+ 7 isozymes] beta-ketoacyl-[acyl-carrier- HMPREF2590_RS25310 [+ 2 isozymes] a uracil in DNA glycerophosphoserine beta-ketoacyl-[acyl-carrier- tyrosine--tRNA ligase: -acetylmuramoyl-L-alanyl-γ- UDP-N-acetyl-α-D-glucosamine branched 2,3,4- cyclohexene-on-oyl octadecenoyl-CoA diphospho)-2-C- oxodocosanoyl- oxotetracos- oxooctadec- methionine a (3R)-3- protein] synthase II: sphingosylphosphorylcholine diphosphate SAM phosphoenol mutase: L-citrulline sulfate reduction octadecenedioate IMP protein] synthase II: dTDP-4-dehydro- HMPREF2590_RS21995 an L-tyrosyl- D-glutamyl-L-lysyl- D-alanine saturated fatty acid long-chain fatty carboxylesterase: acetyl-CoA C- uracil-DNA glycosylase: glycerophosphodiester methyl-D-erythritol [acp] 5-enoyl-[acp] 11-enoyl-[acp] an (11Z)-3- HMPREF2590_RS12060 pyruvate HMPREF2590_RS23620 glyceraldehyde-3- III (assimilatory) undecaprenyldiphospho- long-chain fatty 4-(cytidine 5'- 3-oxoacyl-[acyl-carrier- 3-oxoacyl-[acyl-carrier- 3-oxoacyl-[acyl-carrier- peptide-methionine hydroxybutanoyl- a (7Z)-3- HMPREF2590_RS12060 a sphingosine 6-deoxy-α-D- [tRNA Tyr ] acid--CoA ligase: acyltransferase: HMPREF2590_RS17060 oxo-icos-11- D-glucosamine phosphate dehydrogenase: muramoylpentapeptide beta-N- acid--CoA ligase: HMPREF2590_RS22125 phosphodiesterase: diphospho)-2-C-methyl- protein] reductase: protein] reductase: protein] reductase: (S)-S-oxide reductase: fluoride RS22020 fluoride [acp] oxotetradec- ceramide enolase: glucopyranose a tRNA Tyr hydrogen selenide HMPREF2590_RS19275 HMPREF2590_RS26370 uracil-DNA glycosylase: HMPREF2590_RS19630 GMP reductase: 3-hydroxyacyl-ACP enoyl-[acp] 1-phosphate HMPREF2590_RS22170 sulfate acetylglucosaminyltransferase: HMPREF2590_RS08940 carboxylesterase: D-erythritol kinase: HMPREF2590_RS05100 HMPREF2590_RS05100 HMPREF2590_RS05100 HMPREF2590_RS09535 7-enoyl-[acp] HMPREF2590_RS22150 dTDP-4-dehydrorhamnose [+ 5 isozymes] [+ 2 isozymes] HMPREF2590_RS26635 a protein-L- HMPREF2590_RS26895 3-oxoacyl-ACP reductase: presqualene SAH HMPREF2590_RS05395 [+ 5 isozymes] HMPREF2590_RS20810 [+ 4 isozymes] 2-phospho-4-(cytidineHMPREF2590_RS08150 [+ 7 isozymes] [+ 7 isozymes] [+ 7 isozymes] dehydratase FabZ: 3-oxoacyl-ACP reductase: bifunctional UDP-N- 3,5-epimerase: sulfate adenylyltransferase: a 2-methyl ω-carboxy- 6-hydroxy-2- an apyrimidinic a (3R)-3- a (3R,5Z)-3- a (3R,11Z)-3- 2-phospho- sulfate activation palmitoleoyl-CoA acetyl-CoA uracil sn-glycerol methionine- HMPREF2590_RS12465 HMPREF2590_RS19475 HMPREF2590_RS19475 diphosphate acetylglucosamine thiosulfate disproportionation HMPREF2590_RS16520 ditrans,octacis-undecaprenyldiphospho-[+ 2 isozymes] branched salicyl alcohol cyclohexen- site in DNA ser 5'-diphospho)-2-C- hydroxydocosanoyl- hydroxytetracos- hydroxyoctadec- 5'-methylthioadenosine/ HMPREF2590_RS22820 13-DPG AMP diphosphate AMP diphosphate (9Z)-octadec- 3-phosphate (S)-S-oxide GMP fluoride RS22025 fluoride [+ 5 isozymes] D-glycerate diphosphorylase/ for sulfonation IV (rhodanese) UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- 2,3,4-saturated one-carboxylate methyl-D-erythritol [acp] 5-enoyl-[acp] 11-enoyl-[acp] a (2E)-but- [+ 5 isozymes] long-chain fatty S-adenosylhomocysteine [+ 2 isozymes] tryptophan--tRNA ligase: APS 9-enoyl-CoA a (3R,11Z)-3- 2,3-bisphosphoglycerate- phosphate acquisition γ 2-enoyl-[acp] a (3R,7Z)-3- nucleosidase: glucosamine-1-phosphate HMPREF2590_RS04240 L-alanyl- -D-glutamyl-L-lysyl-D-alanine fatty acyl-CoA hydroxy-icos- acid activation dTDP-4-dehydro- Trp sulfate hydroxytetradec- independent N-acetyltransferase GlmU: a tRNA thiosulfate phosphoadenylyl- 11-enoyl-[acp] HMPREF2590_RS07710 β-L-rhamnose tryptophan--tRNA ligase: phosphoglycerate kinase: crotonyl-[acyl-carrier- 7-enoyl-[acp] a long-chain phosphoglycerate mutase: HMPREF2590_RS08130 sulfate adenylyltransferase: rhodanese domain- sulfate reductase: a phosphate biotin RS21225 biotin hydroxysqualene [+ 4 isozymes] dTDP-4-dehydrorhamnose HMPREF2590_RS18925 HMPREF2590_RS22165 decaprenyl-diphospho-N- UDP-N-acetyl- a 3-methyl- an [amino group carrier protein]- 4-trans-3-oxo- a 3,5,7,9,11,13,15- a 2'- a (5Z)-3- a (6Z)-3- a [protein]-L- protein] reductase: fatty acid HMPREF2590_RS22155 N-acetyl-α-D- an L-tryptophanyl- HMPREF2590_RS16520 containing protein: HMPREF2590_RS16515 monoester decanoate a [protein] N-terminal- long-chain fatty Trp α branched 2,3,4- C-terminal-γ-(L-glutamate 5- MEP CTP oxododec- oxooctadec- HMPREF2590_RS04185 reductase: [tRNA ] acid phosphatase: acetylmuramoyl-pentapeptide -D-glucosamine formyl-L-methionine undecenoyl-CoA hepta-oxo- deoxyribonucleoside methionine dIDP S-ribosyl-L-homocysteine 3-phospho- glucosamine APS HMPREF2590_RS09665 undecaprenyldiphospho- deoxynucleoside kinase: acid--CoA ligase: HMPREF2590_RS22810 trp sulfite saturated fatty acidlong-chain fatty long-chain fatty semialdehyde-2-yl)-L-glutamate peptide deformylase: acetyl-CoA C- hexadecanoyl-[PKS-acp] 2-C-methyl-D- 5-enoyl-[acp] 6-enoyl-[acp]3-oxoacyl-[acyl-carrier- peptide-methionine D-glycerate 1-phosphate 3-phospho-D-glycerate sulfite thiocyanate HMPREF2590_RS24580 N-acetyl-gamma-glutamyl- aldo/keto reductase: 3-oxoacyl-ACP reductase: a butanoyl-[acp] a (2E,7Z)- a (2E,11Z)-icosa- HMPREF2590_RS19275 muramoylpentapeptide beta-N- acid--CoA ligase: HMPREF2590_RS05185 acyltransferase: HMPREF2590_RS08285 erythritol 4-phosphate protein] reductase: nucleoside- biotin RS20735 biotin [+ 2 isozymes] adenylyl-sulfate kinase: phosphate acid--CoA ligase: phosphate reductase: (R)-S-oxide reductase: tetradeca-2,7- 2,11-dienoyl-[acp] S-ribosylhomocysteine phosphoglycerate kinase: bifunctional UDP-N- acetylglucosaminyltransferase: HMPREF2590_RS08940 peptide deformylase: HMPREF2590_RS21680 HMPREF2590_RS23500 deoxynucleoside kinase: HMPREF2590_RS19475 a long-chain[+ 5 isozymes] preQ biosynthesis dTDP-β-L- HMPREF2590_RS16525 HMPREF2590_RS08940 cytidylyltransferase: HMPREF2590_RS05100 HMPREF2590_RS26815 diphosphate kinase: squalene 0 HMPREF2590_RS05395 HMPREF2590_RS06520 [+ 5 isozymes] [+ 5 isozymes] 3-oxoacyl-[acyl-carrier- dienoyl-[acp] lyase: HMPREF2590_RS22165 acetylglucosamine rhamnose 2,3-bisphosphoglycerate- 2,3-diphosphoglycerate- [+ 5 isozymes] an [amino group carrier protein]- HMPREF2590_RS05715 [+ 2 isozymes] HMPREF2590_RS08290 HMPREF2590_RS08385 a protein-L- HMPREF2590_RS16990 7 (2E,11Z)-icosa-2,11- fatty acyl-CoA [+ 5 isozymes] 9-hydroxy-3,5,7,11,13,15- a 2'- 4-(cytidine 5'- a (3R,5Z)-3- a (3R,6Z)-3-[+ 7 isozymes] cis-∆ -tetradecenoyl- HMPREF2590_RS27320 diphosphorylase/ independent dependent a 3-methyl- an N-terminal L- 2-trans- protein] reductase: threonine--tRNA ligase: PAPS [+ 2 isozymes] C-terminal-γ-(5-phospho- formate acetyl-CoA deoxyribonucleoside hydroxydodec- methionine- dienoyl-[acp] reductase: hydrogen sulfide decaprenyl-pyrophosphoryl- branched diphosphate decanoyl-CoA methionyl-[protein] nonenoyl-CoA hexaoxohexadecanoyl- diphospho)-2-C- hydroxyoctadec- K(+)- HMPREF2590_RS05100 [acp]:NAD+ squalene--hopene cyclase: squalene--hopene cyclase: 13-DPG glucosamine-1-phosphate HMPREF2590_RS10940 phosphoglycerate mutase: phosphoglycerate glyphosate degradation II diphosphate AMP AMP L-glutamyl)-L-glutamate (R)-S-oxide dITP HMPREF2590_RS04185 AI-2 GTP thr UDP (N-acetylglucosamine)-N- 2,3,4-saturated [PKS-acp] 5'-monophosphate methyl-D-erythritol 5-enoyl-[acp] 6-enoyl-[acp] K + transporting K + [+ 2 isozymes] oxidoreductase: HMPREF2590_RS20370 HMPREF2590_RS20370 N-acetyltransferase GlmU: HMPREF2590_RS22155 mutase: gpmA threonine--tRNA ligase: acetylmuramyl-(pentapeptide) ATPase HMPREF2590_RS04185 GTP cyclohydrolase I FolE: glyceraldehyde-3- HMPREF2590_RS08130 fatty acyl-CoA a 3-oxohexanoyl- a gondoyl-[acp] HMPREF2590_RS02545 an L-threonyl- glyphosate tetrahymanol 7,8- HMPREF2590_RS16970 triose-phosphate phosphate dehydrogenase: UDP-N-acetyl- a (7Z)-tetradec- UDP-α-D-galactose biosynthesis [tRNA Thr ] 2-phospho-D-glycerate glycine oxidase ThiO: [acp] hop-22(29)-ene hopan-22-ol isomerase: α 7-enoyl-[acp] dihydroneopterin HMPREF2590_RS22170 -D-glucosamine Thr ditrans,octacis- 5-cis, 7-trans-3-oxo- methyl (indol- a (3R)-3- a (3R,5Z)-3- a (3R)-3- predicted a tRNA HMPREF2590_RS24985 7-hydroxylaurate octanoate coenzyme A NADP + a cis-delta21-3- a nucleoside 3-oxoacyl-[acyl-carrier- (2R,4S)-2-methyl-2,4- 3'-triphosphate HMPREF2590_RS22160 D-glyceraldehyde a peptidoglycan with undecaprenyldiphospho- hydroxyhexacosanoyl- hydroxy-tetradec- hydroxyicosanoyl- UDP-α-D-glucose aminomethylphosphonate glyoxylate tetradecadienoyl-CoA 3-yl)acetate GTP H O diphosphate IDP + ATP-driven + 3-oxoacyl-[acyl-carrier- DHAP enolase: 2 oxo-C40:1-[acp] K K protein] reductase: dihydroxydihydrofuran-3-one 6-carboxytetrahydropterin 3-phosphate (L-alanyl-γ-D-glutamyl- N-acetyl-(N-acetyl-β-D- long-chain fatty long-chain fatty CoA-disulfide reductase: acetyl-CoA C- carboxylesterase: [acp] 5-enoyl-[acp] [acp] 3-oxoacyl-[acyl-carrier- transporter protein] reductase: UDP-glucose 4-epimerase: HMPREF2590_RS22150 GTPase Era: 3-hydroxyacyl-ACP 3-oxoacyl-ACP reductase: 3-hydroxyacyl-ACP nucleoside- HMPREF2590_RS05100 synthase QueD: L-lysyl-D-alanyl-D- glucosaminyl)muramoyl- acid--CoA ligase: acid--CoA ligase: HMPREF2590_RS04035 acyltransferase: HMPREF2590_RS22125 protein] reductase: nucleoside- of K+ HMPREF2590_RS05100 biotin-carboxyl carrier protein assembly 2-methyltetrahymanol HMPREF2590_RS00475 HMPREF2590_RS07345 dehydratase FabZ: HMPREF2590_RS19475 dehydratase FabZ: diphosphate kinase: [+ 7 isozymes] adenosyl hopane 2-methyldiplopterol HMPREF2590_RS16110 alanine) pentapeptide L-alanyl-γ-D-glutamyl-L- HMPREF2590_RS08940 HMPREF2590_RS08940 CoA-disulfide reductase: HMPREF2590_RS21680 carboxylesterase: HMPREF2590_RS05100 diphosphate kinase: [+ 2 isozymes] UDP-glucose 4- peptidoglycan [+ 7 isozymes] HMPREF2590_RS12465 HMPREF2590_RS12465 HMPREF2590_RS16990 a (3R)-3- lysyl-D-alanyl-D-alanine [+ 5 isozymes] [+ 5 isozymes] [+ 2 isozymes] HMPREF2590_RS20810 [+ 5 isozymes] 2+ 2+ a (9Z)-3- a [biotin carboxyl- 6-carboxy-5,6,7,8- α ser a peptidoglycan with transglycosylase: HMPREF2590_RS24785 a (5Z)-3-oxo- [+ 7 isozymes] HMPREF2590_RS16990 Mg RS28595 Mg hydroxyhexanoyl- (2R,4S)-2-methyl-2,3,3,4- fructose-1,6-bisphosphate UDP-N-acetyl- -D- epimerase GalE: serine--tRNA ligase: phosphoenolpyruvate (3Z,5E)-dodeca- + a cis-delta21-3- a nucleoside tetrahydropterin γ di-trans,octa-cis H + NADPH CoA-disulfide acetyl-CoA MeOH (indol-3-yl)acetate phosphate GDP H a (2E)-hexacos- a (2E)-icos- oxohexadec- carrier protein]-L-lysine tetrahydroxytetrahydrofuran aldolase, class II: mannosaminouronate (L-alanyl- -D-glutamyl- HMPREF2590_RS25965 7-hydroxylauroyl- 3,5-dienoyl-CoA tetradec-5- hydroxyC40:1- triphosphate [acp] HMPREF2590_RS26875 HMPREF2590_RS08270 an L-seryl- -undecaprenyl AMP diphosphate diphosphate AMP octanoyl-CoA 2-enoyl-[acp] 2-enoyl-[acp] ITP 9-enoyl-[acp] biotin--[acetyl-CoA- 7-carboxy-7-deazaguanine HMPREF2590_RS26320 UDP-α-D-glucose biosynthesis I biosynthesis UDP-α-D-galactose L-lysyl-D-alanyl-D- CoA enoyl-[acp] [acp] 3-hydroxyacyl-ACP [tRNA ser ] diphosphate 3-oxoacyl-[acyl-carrier- carboxylase] ligase: synthase QueE: UDP-N-acetyl- pyruvate kinase: alanine) pentapeptide Co 2+ Co 2+ dehydratase FabZ: a tRNA ser phosphoenolpyruvate reactive oxygen species degradation Detoxification RS06285 ribosyl hopane D-glucopyranose α-D-glucosamine HMPREF2590_RS18845 arsenate detoxification 2+ 2+ HMPREF2590_RS12465 protein] reductase: HMPREF2590_RS17100 HMPREF2590_RS16115 UDP-N-acetylglucosamine synthase: oxidized GTP and dGTP detoxification Mg Mg 6-phosphate pyruvate kinase: II (glutaredoxin) HMPREF2590_RS05100 a [biotin carboxyl-carrier 7-carboxy-7- β 2-epimerase: HMPREF2590_RS01705 a (2E)-hex- -D-fructose 1,6- phosphoglucomutase: a very-long- an all-trans (5E)-3-oxo- a (3R)-3- a (9Z)-3-oxo- a (3R,6Z)-3- a [protein]- (3R,5S)-3- [+ 7 isozymes] 6 deazaguanine HMPREF2590_RS11050 superoxide 16-hydroxypalmitate 4-dimethylaminophenylazobenzene decanoyl-CoA acetyl-CoA a cis-delta19-3- protein]-N -biotinyl-L-lysine bisphosphate HMPREF2590_RS21235 αHMPREF2590_RS22500 chain fatty acid a palmitoleoyl-[acp] a malonyl-[acp] -retinyl ester dodec-5- hydroxytetracosanoyl- octadec-9- hydroxyoctadec- hydroxy-1- 2-enoyl-[acp] a (3R,9Z)-3- α-D-glucopyranose UDP-N-acetyl- - arsenate dGTP GTP oxo-C38:1-[acp] L-arginine 7-cyano-7-deazaguanine long-chain fatty long-chain fatty azoreductase: carboxylesterase: acetyl-CoA C- enoyl-CoA [acp] pyrroline-5- a purine RS26620 a purine hydroxyhexadec- D-mannosamine proline--tRNA ligase: superoxide dismutase: 3-oxoacyl-[acyl-carrier- acetyl-CoA C- enoyl-[acp] 6-enoyl-[acp] 3-oxoacyl-[acyl-carrier- hexanoyl-[acyl-carrier- formyl hopane synthase QueC: 1-phosphate pyruvate acid--CoA ligase: 3-hydroxyacyl-ACP 3-oxoacyl-ACP reductase: 3-hydroxyacyl-ACP protein arginine kinase: pyrroline-5- 9-enoyl-[acp] HMPREF2590_RS27720 HMPREF2590_RS07225 acid--CoA ligase: protein] reductase: HMPREF2590_RS09815 HMPREF2590_RS22125 acyltransferase: protein] reductase: carboxylate protein] reductase: HMPREF2590_RS16105 UDP-N-acetyl-D- pro acyltransferase: dehydratase FabZ: HMPREF2590_RS19475 dehydratase FabZ: HMPREF2590_RS08360 a [biotin carboxyl- UTP--glucose-1-phosphate PRPP biosynthesis proline--tRNA ligase: [+ 4 isozymes] HMPREF2590_RS08940 HMPREF2590_RS19275 HMPREF2590_RS05100 azoreductase: carboxylesterase: HMPREF2590_RS26370 HMPREF2590_RS05100 carboxylate reductase: HMPREF2590_RS04185 mannosamine arsenite HMPREF2590_RS21680 HMPREF2590_RS12465 [+ 5 isozymes] HMPREF2590_RS12465 carrier-protein dimer]- F6P uridylyltransferase: HMPREF2590_RS04940 8-oxo-dGTP 8-oxo-GTP [+ 5 isozymes] [+ 5 isozymes] HMPREF2590_RS26695 HMPREF2590_RS20810 [+ 2 isozymes] a [protein]- HMPREF2590_RS23495 preQ dehydrogenase: an L-prolyl- hydrogen [+ 2 anisozymes] (11Z)-3- [+ 2 isozymes] a (3R,9Z)-3- a (2E,6Z)- a cis-delta19-3-[+ 7 isozymes] ω a purine RS17255 a purine 6 0 HMPREF2590_RS21230 N,N-dimethyl-1,4- 3-oxododecanoyl- a (2E)-tetracos- N -phospho- N -biotinyl-L-lysine HMPREF2590_RS22890 D-ribose 5- [tRNA Pro ] peroxide 16-hydroxypalmitoyl- a very-long-chain aniline a fatty acid all-trans-retinol (3E)-dec-3- hydroxy-octadec- octadecadienoyl- [+ 3 isozymes] a hexanoyl-[acp] a (2E,9Z)- 8-oxo-dGTP diphosphatase: acyl-carrier protein oxooctadec- phenylenediamine CoA acetyl-CoA hydroxyC38:1- glucose-6-phosphate UTP--glucose-1-phosphate phosphate a tRNA Pro arsenical pump- AMP diphosphate AMP diphosphate enoyl-CoA 2-enoyl-[acp] L-arginine Hyp acetyl-CoA carboxylase UDP-N-acetyl-α-D- ribose-phosphate glycolysis III (from glucose) HMPREF2590_RS22260 CoA fatty acyl-CoA 11-enoyl-[acp] 9-enoyl-[acp] [acp] [acp] hexadeca-2,9- isomerase: uridylyltransferase: driving ATPase: 3-oxoacyl-[acyl-carrier- acetyl-CoA carboxylase biotin carboxylase subunit: bacteriohopanetetrol aminobacteriohopanetriol mannosaminuronate pyrophosphokinase: catalase: dienoyl-[acp] HMPREF2590_RS21125 HMPREF2590_RS22900 HMPREF2590_RS28180 8-oxo-dGTP diphosphatase: a purine RS09060 a purine protein] reductase: carboxyl transferase: HMPREF2590_RS13535 HMPREF2590_RS08125 HMPREF2590_RS01285 palmitoleoyl-[acp]:NAD+ D-glucopyranose D-glucopyranose HMPREF2590_RS01565 8-oxo-GMP HMPREF2590_RS05100 HMPREF2590_RS11060 acetyl-CoA carboxylase α [+ 2 isozymes] 6 oxidoreductase: 6-phosphate UDP- -D-glucose PRPP an N -L- 3-oxo-(9Z)- all-trans- a (7Z)-3-oxo- a (3R)-3- a double-stranded a [protein]- H O hydroxyl radical 18-hydroxystearate α-linolenate 37 a cis-delta17-3- a nucleoside [+ 2 isozymes] HMPREF2590_RS04185 HMPREF2590_RS11065 biotin carboxylase subunit: phenylalanine--tRNA ligase: glucokinase: 2 8-oxo-dGMP superoxide threonylcarbamoyladenine 2-oxoadipate a RNA-DNA hybrid hexadec-7- phe octadecenoyl-CoA retinyl palmitate hydroxydocosanoyl- oligonucleotide triphosphate L-tyrosine HMPREF2590_RS06790 HMPREF2590_RS07165 bifunctional oxo-C36:1-[acp] tyrosine protein kinase: a sugar RS08100 a sugar a 3-oxooctanoyl- 2-methylbacteriohopanetetrol HMPREF2590_RS10860 O arsenite radicals degradation long-chain fatty long-chain fatty in tRNA tRNA acetyl-CoA C- 2-oxoglutarate carboxylesterase: ribonuclease enoyl-[acp] [acp] 3-oxoacyl-[acyl-carrier- a palmitoleoyl-[acp] a [carboxyl-carrier 2 3-oxoacyl-ACP reductase: 3-hydroxyacyl-ACP nucleoside [acp] HMPREF2590_RS10865 an L-phenylalanyl- D-glucopyranose acid--CoA ligase: acid--CoA ligase: threonylcarbamoyladenosine acyltransferase: dehydrogenase HMPREF2590_RS20810 HI: rnhA oligoribonuclease/PAP protein] reductase: HMPREF2590_RS22910 protein dimer]-N 6 - HMPREF2590_RS19475 dehydratase FabZ: triphosphatase YtkD: [tRNA Phe ] 6-phosphate superoxide HMPREF2590_RS08940 HMPREF2590_RS19275 HMPREF2590_RS26370 E1 component: carboxylesterase: phosphatase NrnA: HMPREF2590_RS05100 tyrosine protein kinase: 3-oxoacyl-[acyl-carrier- Amine and Polyamine Biosynthesis dehydratase: ribonuclease HII: HMPREF2590_RS27290 carboxybiotinyl-L-lysine Phe superoxide dismutase: HMPREF2590_RS04005 [+ 5 isozymes] HMPREF2590_RS12465 HMPREF2590_RS11095 HMPREF2590_RS22920 phosphatidylglycerol Aromatic Compound Biosynthesis a tRNA glucose-6-phosphate [+ 5 isozymes] [+ 5 isozymes] a cyclic N 6 -L-HMPREF2590_RS07855 [+ 2 isozymes] HMPREF2590_RS22125 HMPREF2590_RS05030 a (3R,7Z)-3- [+ 7 isozymes] a [protein]- a sugar RS25825 a sugar protein] reductase: HMPREF2590_RS07225 (7Z)- a nucleoside 5'- a (2E)-docos- a nucleoside 5'- a cis-delta17-3- a nucleoside biosynthesis I (plastidic) isomerase: 18-hydroxystearoyl- threonylcarbamoyladenosine acetyl-CoA glutaryl-CoA NADH CO palmitate all-trans-retinol DNA hydroxy-hexadec- L-tyrosine HMPREF2590_RS05100 spermidine biosynthesis III AMP diphosphate AMP diphosphate α-linolenoyl-CoA hexadecenoyl-CoA 2 monophosphate 2-enoyl-[acp] monophosphate hydroxyC36:1- diphosphate bacillibactin biosynthesis putrescine biosynthesis I HMPREF2590_RS21125 hydrogen[+ 4 isozymes] CoA 37 in tRNA 7-enoyl-[acp] phosphate [+ 7 isozymes] palmitoleate chorismate biosynthesis I [acp] a (3R)-3- DHAP peroxide predicted glycerol-3-phosphate phosphatidylethanolamine methionine--tRNA ligase: F6P hydroxyoctanoyl- D-erythrose arg SAM catalase: ABC dehydrogenase (NAD(P)(+) biosynthesis I chorismate arg HMPREF2590_RS21830 a sugar a sugar [acp] 4-phosphate met 6-phosphofructokinase: HMPREF2590_RS01285 (15Z)- a DNA containing 3-oxo-(7Z)- a (1->4)- guanosine 2251 a guanine 527 an organic a SpoIVB transporter 3-hydroxyacyl-ACP ): HMPREF2590_RS16940 methionine--tRNA ligase: pristanate a [protein]- hydrogencarbonate H + glycerophosphoglycerol (S)-dihydroorotate a cis-delta15-3- isochorismate adenosylmethionine HMPREF2590_RS11055 Amine and Polyamine Degradation [+ 2 isozymes] tetracosenoate S methyl hexadecenoyl-CoA α-D-glucan hydroperoxide peptidase of a sugar sn-glycerol a CDP-diacylglycerol 3-deoxy-7- an L-methionyl- p L-cysteine in 23S rRNA in 16S rRNA oxo-C34:1-[acp] dehydratase FabZ: synthase EntC: decarboxylase: HMPREF2590_RS08185 long-chain fatty long-chain fatty phosphotriester acetyl-CoA C- alpha-glucosidase: carbonic anhydrase: glycerophosphodiester 23S rRNA 16S rRNA thioredoxin-dependent Precursor 3-phosphate CDP-diacylglycerol--serine phosphoheptulonate [elongator β-D-fructose 1,6- O methylated-DNA-- 3-oxoacyl-[acyl-carrier- HMPREF2590_RS12465 HMPREF2590_RS02635 HMPREF2590_RS10970 agmatine 2 HMPREF2590_RS27845 dihydroorotase: elongator Met acid--CoA ligase: acid--CoA ligase: [protein]-cysteine S- acyltransferase: HMPREF2590_RS02220 phosphodiesterase: (guanosine(2251)-2'-O)- (guanine(527)-N(7))- protein] reductase: thiol peroxidase: a sugar RS05905 a sugar glycerol-3-phosphate O-phosphatidyltransferase: synthase: tRNA ] bisphosphate N-acetylglucosamine SpoIVB peptidase: isochorismate synthase: agmatine Met HMPREF2590_RS08940 HMPREF2590_RS08940 HMPREF2590_RS26370 alpha-glucosidase: carbonic anhydrase: HMPREF2590_RS06710 methyltransferase RlmB: methyltransferase RsmG: HMPREF2590_RS05285 HMPREF2590_RS00980 a (2E)-oct- HMPREF2590_RS19705 HMPREF2590_RS14120 tRNA degradation I 4-aminobutanoate degradation I 4-aminobutanoate degradation III methyltransferase: HMPREF2590_RS05100 HMPREF2590_RS06735 acyltransferase: HMPREF2590_RS27640 dAdoMet agmatinase: HMPREF2590_RS05920 HMPREF2590_RS08415 HMPREF2590_RS03735 2-enoyl-[acp] [+ 5 isozymes] [+ 5 isozymes] HMPREF2590_RS04545 [+ 2 isozymes] HMPREF2590_RS27330 [+ 4 isozymes] 2-O- an N 7 - [+ 7 isozymes] [+ 2 isozymes] HMPREF2590_RS20610 [+ 2 isozymes] 3-deoxy-7- HMPREF2590_RS26495 fructose-1,6-bisphosphate N-acetyl-D- a DNA without (5Z)- a (1->4)- N-carbamoyl- a cis-delta15-3- a 3-sn-phosphatidyl- a [protein]-S- acetyl-CoA D-glucopyranose H O CO sn-glycerol 2251 527 an alcohol a SpoIVB octanoyl-[acyl-carrier- aldolase, class II: 4-aminobutanoate 4-aminobutanoate (Z)-15- S methyl α-D-glucan 2 2 glycerol methylguanosine methylguanine L-aspartate hydroxyC34:1- a sugar RS25360 a sugar glycerol-3-phosphate L-serine isochorismate phosphoheptulonate polyamine glucosamine AMP diphosphate AMP diphosphate pristanoyl-CoA methyl-L-cysteine p tetradecenoyl-CoA 3-phosphate peptidase protein] reductase: putrescine HMPREF2590_RS26320 4-aminobutyrate--2- 4-aminobutyrate--2- tetracosenoyl-CoA phosphotriester in 23S rRNA in 16S rRNA [acp] acyltransferase: phosphatidylserine synthase: aminopropyltransferase: 6-phosphateN-acetylglucosamine-6- urea degradation I HMPREF2590_RS04185 isochorismatase: a tRNA Lys oxoglutarate transaminase: oxoglutarate transaminase: HMPREF2590_RS08825 decarboxylase: HMPREF2590_RS11480 HMPREF2590_RS26500 phosphate deacetylase: lysine--tRNA ligase: HMPREF2590_RS28135 HMPREF2590_RS28135 oxalate oxalate a 1-acyl-sn HMPREF2590_RS02625 3-deoxy- triose-phosphate HMPREF2590_RS06130 an octanoyl-[acp] HMPREF2590_RS07535 1 HMPREF2590_RS07980 an L-lysyl- D-glucosamine succinate semialdehyde urea -glycerol 3- (2S,3S)-2,3- D-arabino- S-methyl-5'- N -(3-aminopropyl) succinate semialdehyde an [apo BCAA 3-oxo-(9Z)- an apo-[LYS2 L- 34 966 22 phosphoenol RS00380 Lys isomerase: 6-phosphate a guanine a guanine an adenine an L-1- thioadenosine agmatine [tRNA ] 18-hydroxyoleate phytenate 2-aminoadipyl- hexanoyl-CoA acetyl-CoA queuine ADP-D-ribose a cis-delta13-3- phosphate dihydroxy-2,3- heptulosonate HMPREF2590_RS22160 NAD-dependent 4-methyl-2- dehydrogenase hexadecenoyl-CoA coenzyme A in tRNA in 16S rRNA in tRNA pyruvate a protein formate formate phosphatidylethanolamine 1 D-glyceraldehyde oxo-C32:1-[acp] 3-oxoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- dihydrobenzoate 7-phosphate N -aminopropylagmatine lys succinate-semialdehyde long-chain fatty long-chain fatty oxopentanoate E2 protein] N 6 acetyl-CoA C- carrier-protein] holo-ACP synthase: acetyl-CoA C- tRNA guanosine(34) ADP-ribose 16S rRNA 3-oxoacyl-[acyl-carrier- pyruvate kinase: DHAP succinate-semialdehyde tRNA (adenine(22)-N(1))- AI-2 RS01040 protein] reductase: phosphate acyltransferase: ureohydrolase: 3-phosphate dehydrogenase: gabD urea-1-carboxylate acid--CoA ligase: branched-chain alpha- acyltransferase: acyltransferase: transglycosylase Tgt: pyrophosphatase: (guanine(966)-N(2))- HMPREF2590_RS18845 HslU--HslV peptidase AI-2 2,3-dihydro-2,3- 3-dehydroquinate synthase: dehydrogenase: gabD acid--CoA ligase: -lipoyl-L-lysine HMPREF2590_RS12120 methyltransferase TrmK: protein] reductase: HMPREF2590_RS05100 HMPREF2590_RS23435 HMPREF2590_RS26495 glyceraldehyde-3- α-D-glucosamine HMPREF2590_RS08940 HMPREF2590_RS19275 keto acid dehydrogenase: HMPREF2590_RS26370 HMPREF2590_RS26370 HMPREF2590_RS07930 HMPREF2590_RS10420 methyltransferase RsmD: pyruvate kinase: ATPase subunit: dihydroxybenzoate HMPREF2590_RS17000 a [apo BCAA dehydrogenase a holo-[LYS2 L- [+ 3 isozymes] HMPREF2590_RS07300 HMPREF2590_RS05100 phosphate dehydrogenase: succinate allophanate HMPREF2590_RS14765 1 HMPREF2590_RS04990 [+ 2 isozymes] 6-phosphate succinate [+ 5 isozymes] 6 [+ 2 isozymes] [+ 2 isozymes] 34 2 HMPREF2590_RS05495 N - HMPREF2590_RS11050 1-acyl-sn-glycerol-3- dehydrogenase: [+ 5 isozymes] E2 protein] N -S-[3- 2-aminoadipyl- 3',5'-ADP a queuosine D-ribofuranose an N - [+ 7 isozymes] α spermidine histidine--tRNA ligase: HMPREF2590_RS22170 hydrolase subunit 1: (7Z)- 3-oxooctanoyl- guanine AMP 22 a cis-delta13-3- -diglucosyldiacylglycerol 966 methyladenine AI-2 RS01045 a 3-oxodecanoyl- phosphate acyltransferase: HMPREF2590_RS02640 3-dehydroquinate glucosamine-6- 18-hydroxyoleoyl- methylbutanoyl]dihydrolipoyl- acetyl-CoA carrier-protein] in tRNA 5-phosphate methylguanine pyruvate a peptide AI-2 biosynthesis HMPREF2590_RS07865 HMPREF2590_RS01620 AMP diphosphate diphosphate AMP phytenoyl-CoA tetradecenoyl-CoA CoA in tRNA hydroxyC32:1- [acp] HMPREF2590_RS03160 2,3- his phosphate deaminase: CoA L-lysine in 16S rRNA a 1,2-diacyl- 3-dehydroquinate histidine--tRNA ligase: 13-DPG [acp] dihydroxybenzoate HMPREF2590_RS06125 ammonium 3-oxoacyl-[acyl-carrier- sn-glycerol a 1,2-diacyl-sn-glycerol gly dehydratase: HMPREF2590_RS18815 an L-histidyl- protein] reductase: (2,3-dihydroxybenzoyl) citrate RS25860 citrate 3-phosphate HMPREF2590_RS06870 [tRNA His ] phosphoglycerate kinase: F6P adenylate synthase: HMPREF2590_RS05100 phosphatidate a tRNA His HMPREF2590_RS22165 a nascent peptidoglycan a peptidoglycan 2-phospho-4-(cytidine 5'- 4-hydroxybenzoyl- (1S,2R)-1- a cytidine 1402 6-methoxy-2-all- adenine 37 a [protein]- a 1,2-diacyl-3-O-(α-D- HMPREF2590_RS02630 a glutaryl-[acp] acetyl-CoA a peptide with a 4-methylcatechol a cis-delta11-3- a kanamycin [+ 7 isozymes] cytidylyltransferase: 3-dehydroshikimate with (L-alanyl-γ-D- with (L-alanyl-γ-D- a malonyl-[acp] diphospho)-2-C-methyl-D-erythritol CoA C-(indol-3- in 16S rRNA trans-octaprenyl- in tRNA val L-histidine glucopyranosyl)-sn-glycerol (2,3- 3-phospho- methyl ester leader sequence ser 1 oxo-C30:1-[acp] aminoglycoside a (3R)-3- glutamyl-meso-2,6- glutamyl-meso-2,6- 3-oxoacyl-[acyl-carrier- 2-C-methyl-D-erythritol acetyl-CoA C- signal peptidase I: yl)glycerol 1,4-benzoquinone tRNA1(Val) (adenine(37) 3-oxoacyl-[acyl-carrier- formate formate HMPREF2590_RS04955 D-glycerate ribosomal RNA small demethylmenaquinone histidine kinase: RS20425 hydroxydecanoyl- diglucosyl dihydroxybenzoyl) shikimate dehydrogenase: 2,4-cyclodiphosphate acyltransferase: 3-phosphate tryptophan synthase catechol 2,3-dioxygenase: phosphotransferase: nitrite a CDP- diaminopimeloyl-D- L,D-transpeptidase:diaminopimeloyl-D- protein] reductase: HMPREF2590_RS03850 subunit methyltransferase -N6)-methyltransferase: protein] reductase: HMPREF2590_RS07905 nitrite [acp] diacylglycerol synthase: (glycyl)adenylate adenylate HMPREF2590_RS07515 2,3- synthase: HMPREF2590_RS21680 subunit beta: HMPREF2590_RS20245 methyltransferase: HMPREF2590_RS03190 diacylglycerol alanine) tetrapeptide HMPREF2590_RS21805alanine) tetrapeptide HMPREF2590_RS05100 [+ 6 isozymes] H: HMPREF2590_RS05435 HMPREF2590_RS08205 HMPREF2590_RS05100 [+ 6 isozymes] 3-hydroxyacyl-ACP HMPREF2590_RS00860 diphosphoglycerate- Carboxylate Degradation HMPREF2590_RS08390 HMPREF2590_RS04080 (2Z,4E)-2-hydroxy- an N 4 - HMPREF2590_RS16980 an N 6 - [+ 2 isozymes] a [protein]- thr gly levulinate degradation a nascent peptidoglycan [+ 2 isozymes] [+ 2 isozymes] D-glyceraldehyde 3-methyl-6-methoxy- [+ 7 isozymes] CDP-diacylglycerol-- α shikimate [+ 2 isozymes] a leader sequence a peptide 1402 37 a cis-delta11-3- dehydratase FabZ: a 1,2-diacyl-3-O-( -D- glycine--tRNA ligase: dependent acetyl-CoA fermentation to butanoate II with L,D cross links a 3-oxopimeloyl- 2-C-methyl-D-erythritol- 4-hydroxybenzoyl- trp 5-methyl-6-oxohexa- methylcytidine methyladenine a kanamycin N-phospho- formate formate D-ala acyl-carrier protein CMP 3-phosphate 2-octaprenyl-1,4- hydroxyC30:1- RS15940 HMPREF2590_RS12465 glycerol-3-phosphate 3- glucopyranosyl(1->2)-O-α-D- HMPREF2590_RS21210 phosphoglycerate 2,4-cyclodiphosphate acetyl-CoA 2,4-dienoate in 16S rRNA in tRNA val 3'-phosphate L-histidine a 2,3- Gly (meso-diaminopimelate [acp] methyl ester benzoquinone 1 nitrite nitrite phosphatidyltransferase: shikimate kinase: a glycyl-[tRNA ] mutase: gpmA 4-oxopentanoate [acp] a (2E)-dec- glucopyranosyl)-sn-glycerol a glycyl-[DhbF dihydroxybenzoyl- acetyl-CoA containing) HMPREF2590_RS04755 HMPREF2590_RS07020 Gly [DhbB aryl- a tRNA 2-phospho- 2-enoyl-[acp] 1-(3-sn- non-ribosomal D-glycerate 4 formate formate (L-threonyl) peptide synthase] carrier protein] shikimate 3- an O - a (9Z)-3- RS04475 decanoyl-[acyl-carrier- phosphatidyl) acetyl-CoA C- phosphotransacetylase: methylmalonate a malonyl-[acp] a [protein]- an apo-[aryl- an insertion sequence 3-oxo-4-pregnene- adenylate phosphate enolase: a malonyl-[acp] methylthymine coenzyme A butanoyl-CoA acetyl-CoA 3-methylcatechol 3-methylcatechol oxooctacos- thr butanoate nitrite nitrite protein] reductase: -sn-glycerol 4-oxopentanoyl- acetyltransferase: HMPREF2590_RS29470 semialdehyde methyl ester L-cysteine a tRNA precursor CTP ATP carrier protein] element IS30 20-carboxyl-CoA 3-phosphoshikimate 1- HMPREF2590_RS22150 4-hydroxypentanoate methylmalonate- in DNA acetyl-CoA C- acetyl-CoA C- 9-enoyl-[acp] HMPREF2590_RS04185 3-phosphate methionine--tRNA ligase: CoA HMPREF2590_RS05965 phosphate 3-oxoacyl-[acyl-carrier- methylated-DNA-- holo-ACP synthase: transposase: 3-oxoacyl-[acyl-carrier- carboxyvinyltransferase: semialdehyde CCA tRNA acyltransferase: catechol 2,3-dioxygenase: catechol 2,3-dioxygenase: acyltransferase: L-threonine 3- butyrate kinase: phosphatidylglycerophosphatase HMPREF2590_RS21830 phosphoenol [+ 2 isozymes] acetyltransferase: protein] reductase: [protein]-cysteine S- HMPREF2590_RS12120 HMPREF2590_RS23250 protein] reductase: a decanoyl-[acp] a 2,3- HMPREF2590_RS14140 met dehydrogenase nucleotidyltransferase: HMPREF2590_RS26370 HMPREF2590_RS20245 HMPREF2590_RS20245 HMPREF2590_RS21680 dehydrogenase: HMPREF2590_RS06680 A: HMPREF2590_RS21435 methionine--tRNA ligase: pyruvate HMPREF2590_RS26580 HMPREF2590_RS05100 methyltransferase: [+ 3 isozymes] [+ 4 isozymes] HMPREF2590_RS05100 an L-threonyl- dihydroxybenzoyl- 5-enolpyruvoyl- (CoA acylating): a tRNA HMPREF2590_RS17095 a holo-[aryl- [+ 2 isozymes] (2Z,4E)-2-hydroxy- an insertion 2-hydroxy- HMPREF2590_RS25565 an L-1- [+ 2 isozymes] HMPREF2590_RS04545 3',5'-ADP [+ 2 isozymes] [+ 7 isozymes] butanoyl [DhbF non- glycyl-[DhbF shikimate 3- HMPREF2590_RS08185 an L-methionyl- pyruvate kinase: containing a 3-oxohexanoyl- sequence IS30 with 3,22-dioxochol- a cis-delta9-3- 3-oxoacyl-[acyl-carrier- acetoacetyl-CoA HMPREF2590_RS02700 a 3-oxoglutaryl- a [protein]-S- carrier protein] 5-methyl-6-oxohexa- 6-oxohepta- aminoacetone phosphate phosphatidyl- ribosomal non-ribosomal phosphate [initiator tRNA Met ] HMPREF2590_RS18845 4-hydroxypentanoyl- acyl-carrier protein a thymine in DNA 3' CCA end CoA 4-en-24-oyl-CoA hydroxyC28:1- protein] reductase: acetyl phosphate + [acp] methyl ester methyl-L-cysteine 2,4-dienoate integrated transposon 2,4-dienoate sn-glycerol initiator tRNA Met CoA H NADH hydrogencarbonate propanoyl-CoA [acp] HMPREF2590_RS05100 peptide synthase] peptide synthase] chorismate synthase: pyruvate kinase: acetoacetyl-CoA reductase: HMPREF2590_RS16995 HMPREF2590_RS11050 HMPREF2590_RS15980 [+ 2 isozymes] acetate kinase: a 3- chorismate synthase: (3R)-3- 3-[(3aS,4S,7aS)-7a-methyl- a [protein]- pyruvate HMPREF2590_RS11240 3-oxo- 3-oxo-(5Z)- all-trans- a cytidine 1402 a negatively oxododecanoyl- HMPREF2590_RS14125 hydroxybutanoyl- a nucleoside maltohexaose [EntB aryl- 4-(phosphooxy) a palmitoyl-[acp] a malonyl-[acp] 1,5-dioxo-octahydro-1H coenzyme A a ribonucleic acid coenzyme A palmitoyl-CoA tetradecenoyl-CoA retinyl palmitate in 16S rRNA supercoiled DNA a malonyl-[acp] D-cysteine L-tyrosine [acp] a 2,3- CoA triphosphate alpha-glucosidase: carrier protein] stearate biosynthesis pentanoyl-CoA acetate 3-oxoacyl-[acyl-carrier- -inden-4-yl]propanoate acyl-CoA synthetase: holo-ACP synthase: acetyl-CoA C- acetyl-CoA C- carboxylesterase: DNA topoisomerase III: phosphate 3-oxoacyl-[acyl-carrier- dihydroxybenzoyl- chorismate DNA-directed RNA HMPREF2590_RS27845 16S rRNA (cytidine(1402) malonyl-[acyl- protein-tyrosine- II (bacteria and plants) protein] reductase: HMPREF2590_RS20730 HMPREF2590_RS12120 acyltransferase: acyltransferase: HMPREF2590_RS22125 HMPREF2590_RS09800 D-cysteine desulfhydrase: protein] reductase: glycyl-L-arginyl- polymerase subunit delta: -2'-O)-methyltransferase: carrier protein] O- phosphatase: pyruvate fermentation to acetate IV alpha-glucosidase: HMPREF2590_RS26370 HMPREF2590_RS21680 DNA topoisomerase III: HMPREF2590_RS05100 [DhbF non-ribosomal HMPREF2590_RS05100 acyl-CoA synthetase: HMPREF2590_RS26340 [+ 3 isozymes] carboxylesterase: HMPREF2590_RS08195 methyltransferase BioC: HMPREF2590_RS18390 HMPREF2590_RS05920 a 2'-O- HMPREF2590_RS18905 a palmitoyl-[acp] [+ 2 isozymes] 3-[(3aS,4S,7aS)-7a-methyl-HMPREF2590_RS10160 [+ 5 isozymes] a holo-[EntB aryl- [+ 2 isozymes] [+ 2 isozymes] HMPREF2590_RS20810 HMPREF2590_RS27825 HMPREF2590_RS06440 [+ 7 isozymes] peptide synthase] crotonyl-CoA 3',5'-ADP (3Z)-dodec- 1402 a [protein]- 3-oxo-stearoyl- a 3-oxooctadecanoyl- D-glucopyranose maltopentaose carrier protein] myristoyl-CoA acetyl-CoA acetyl-CoA palmitate a retinol methylcytidine a relaxed DNA a malonyl-[acp] pyruvate a (3R)-3- 3-pentenoyl-CoA pyruvate acyl-carrier protein 1,5-dioxo-octahydro-1H- a ribonucleic acid L-tyrosine [acp] 3-enoyl-CoA in 16S rRNA hydroxydodecanoyl- [acp] synthase: acyl-CoA dehydrogenase: inden-4-yl]propanoyl-CoA methyl ester HMPREF2590_RS12485 [acp] a 3-oxooctadecanoyl- HMPREF2590_RS26360 3-hydroxyacyl-ACP formate C- [acp] bacillibactin [+ 8 isozymes] Pentose Phosphate Pathways acetyltransferase: 967 (S)-1-pyrroline- dehydratase FabZ: seleno-L- (+)-7-epi-jasmonoyl-CoA acetyl-CoA maltopentaose AsbD acyl- octanoyl-CoA acetyl-CoA canavaninosuccinate a cytosine a 7,8-dihydrofolate maltose roseoflavin 3-oxoacyl-[acyl-carrier- 2-pentenoyl-CoA butanoyl-CoA HMPREF2590_RS00850 an acetyl-[acp] a malonyl-[acp] coenzyme A in 16S rRNA 5-carboxylate gly HMPREF2590_RS12465 homocysteine alpha-glucosidase: carrier protein alpha-glucosidase: protein] reductase: pentose phosphate pathway (non-oxidative branch) 3-oxoacyl-[acyl-carrier- acetyl-CoA C- holo-ACP synthase: acetyl-CoA C- argininosuccinate lyase: 16S rRNA dihydrofolate reductase: L-glutamate gamma- bifunctional riboflavin a (2E)-dodec- 5-methyltetrahydropteroyltriglutamate- HMPREF2590_RS27845 HMPREF2590_RS27845 HMPREF2590_RS05100 protein] reductase: acyltransferase: HMPREF2590_RS12120 acyltransferase: HMPREF2590_RS20330 (cytosine(967)-C(5))- HMPREF2590_RS03175 semialdehyde kinase/FAD synthetase: glycine oxidase ThiO: 2-enoyl-[acp] acetyl-CoA formate - homocysteine S-methyltransferase: [+ 7 isozymes] D-ribulose HMPREF2590_RS05100 HMPREF2590_RS21680 alpha-glucosidase: [+ 3 isozymes] HMPREF2590_RS26370 argininosuccinate lyase: methyltransferase RsmB: dihydrofolate reductase: alpha-glucosidase: dehydrogenase: HMPREF2590_RS04890 HMPREF2590_RS24985 HMPREF2590_RS05860 dodecanoyl-[acyl-carrier- a (3R)-3- 5-phosphate (3R)-3- [+ 2 isozymes] HMPREF2590_RS05920 a holo-[AsbD acyl- [+ 2 isozymes] HMPREF2590_RS11200 HMPREF2590_RS05175 HMPREF2590_RS25425 HMPREF2590_RS05920 HMPREF2590_RS28215 phosphotransacetylase: [+ 2 isozymes] 3',5'-ADP 967 roseoflavin hydroxyoctadecanoyl- 3-oxo-2-(cis-2'-pentenyl)- carrier protein] 3-oxodecanoyl- a 5-methylcytosine protein] reductase: hydroxypentanoyl- butanoate HMPREF2590_RS29470 SeMet D-glucopyranose maltotetraose fumarate L-canavanine a folate D-glucopyranose glu 5'-phosphate glyoxylate [acp] an acetoacetyl-[acp] acyl-carrier protein cyclopentane-1-(3-oxobutanoyl)-CoA CoA in 16S rRNA HMPREF2590_RS04185 ribulose-phosphate ribose 5-phosphate CoA phosphate 3-hydroxyacyl-ACP 3-epimerase: isomerase A: acetoacetyl-CoA reductase: acetyltransferase: a dodecanoyl-[acp] dehydratase FabZ: HMPREF2590_RS05150 HMPREF2590_RS14865 HMPREF2590_RS15980 HMPREF2590_RS26580 HMPREF2590_RS12465 2-amino-6-[1-hydroxyethyl]- 7,8-dihydrofolate (3R)-3- 3-oxo- a (3R,11Z)-3- ribose 5-phosphate an acyl-[acyl- NADPH H + maltoheptaose methylsalicylate a D-hexose 3-oxopentanoyl- a malonyl-[acp] hydroxyoctadecanoyl- β-alanine L-saccharopine hydroxyoctadec- D-serine a (2E)-octadec- D-xylulose isomerase B: acetyl phosphate carrier protein] 7-methyl-7,8-dihydropterin monoglutamate 4'-phosphopantetheine ATP myristoyl-CoA 3-oxoacyl-[acyl-carrier- CoA 2-amino-4-hydroxy-6- dihydrofolate reductase: alpha-glucosidase: CoA acetyl-CoA C- carboxylesterase: 11-enoyl-[acp] 2-enoyl-[acp] 5-phosphate HMPREF2590_RS26230 beta-ketoacyl-[acyl-carrier- saccharopine glucokinase: protein] reductase: acetyl-CoA C- HMPREF2590_RS25425 HMPREF2590_RS27845 phosphopantetheine acyltransferase: 4-aminobutyrate--2- HMPREF2590_RS22125 3-hydroxyacyl-ACP protein] synthase II: hydroxymethyldihydropteridine acetoacetyl-CoA reductase: dehydrogenase: HMPREF2590_RS07165 D-serine ammonia-lyase: acetate kinase: alpha-glucosidase: oxoglutarate transaminase: dehydratase FabZ: HMPREF2590_RS05100 steroyl-[acp] reductase: acetyltransferase: HMPREF2590_RS12485 diphosphokinase: dihydrofolate reductase: adenylyltransferase: HMPREF2590_RS15980 HMPREF2590_RS26370 carboxylesterase: HMPREF2590_RS16035 HMPREF2590_RS18075 laurate D-ribose 5- HMPREF2590_RS11240 HMPREF2590_RS28135 HMPREF2590_RS12465 [+ 2 isozymes] HMPREF2590_RS04185 HMPREF2590_RS05965 HMPREF2590_RS07995 HMPREF2590_RS03175 HMPREF2590_RS05920 HMPREF2590_RS05490 [+ 2 isozymes] HMPREF2590_RS20810 D-hexose 6- phosphate pyruvate decarboxylation to acetyl CoA [+ 2 isozymes] [1-(2-amino-7-methyl-4-oxo- tetrahydropteroyl 3'-dephospho- 3-oxooctadecanoyl- allysine glu a (2E,11Z)- long-chain fatty [+ 3 isozymes] acetate 7,8-dihydro-3H-pteridin- NADP + D-glucopyranose maltohexaose CoA acetyl-CoA lauroyl-CoA 3-oxopropanoate MeOH salicylate octadeca-2,11- phosphate pyruvate transketolase: acyl-carrier protein a 3-oxoacyl-[acp] mono-L-glutamate CoA acid--CoA ligase: a stearoyl-[acp] a [pyruvate 6-yl)]ethyl diphosphate dienoyl-[acp] a 3-oxotetradecanoyl- HMPREF2590_RS19095 propanoyl-CoA [acp] HMPREF2590_RS08940 dehydrogenase transketolase: [+ 5 isozymes] E2 protein] N 6 3-oxoacyl-[acyl-carrier- HMPREF2590_RS21010 an N 6 -L- (5Z,8Z,11Z,14Z,17Z) 3-oxo-(5Z)- 2-trans, 4-trans a uridine 38- propane- -lipoyl-L-lysine pyruvate dehydrogenase a sulfurated quinoxaline-2- coenzyme A an apo [peptidyl- a D-aminoacyl- a [protein] Ser/Thr protein] reductase: threonylcarbamoyladenine 37 aryl-carrier protein -icosapentaenoate coenzyme A dodecenoyl-CoA -undecadienoyl- 40 in tRNA cys D-ala lauroyl-CoA D-sedoheptulose D-glyceraldehyde (acetyl-transferring) E1 [sulfur carrier] carboxyl adenylate carrier protein] [tRNA] 1,3-diamine biotin ATP HMPREF2590_RS05100 dihydrolipoyl pyruvate in tRNA long-chain fatty acetyl-CoA C- CoA RluA family stearate 7-phosphate 3-phosphate component subunit alpha: superpathway of acetate utilization and formation tRNA (N(6)-L- acyl carrier protein: holo-ACP synthase: D-aminoacyl- HPr kinase/phosphorylase: spermidine N1- [+ 7 isozymes] dehydrogenase: acid--CoA ligase: acyltransferase: pseudouridine synthase: biotin--[acetyl-CoA- HMPREF2590_RS05705 threonylcarbamoyladenosine(37) HMPREF2590_RS12460 HMPREF2590_RS12120 tRNA deacylase: HMPREF2590_RS22295 2,4-dienoyl-CoA reductase: acetyltransferase: cysteine dioxygenase: glycine oxidase ThiO: a (3R)-3- long-chain fatty HMPREF2590_RS06675 HMPREF2590_RS19275 HMPREF2590_RS21680 HMPREF2590_RS04360 carboxylase] ligase: transaldolase: -C(2))- methylthiotransferase [+ 4 isozymes] [+ 3 isozymes] HMPREF2590_RS07875 [+ 3 isozymes] HMPREF2590_RS05800 HMPREF2590_RS22050 HMPREF2590_RS13960 HMPREF2590_RS24985 hydroxytetradecanoyl- acid--CoA ligase: [+ 2 isozymes] acetate a quinoxaline-2- a holo [peptidyl- an uncharged HMPREF2590_RS17100 a [pyruvate a [pyruvate acetate--CoA ligase: MtaB: HMPREF2590_RS07395 6 [+ 5 isozymes] [+ 2 isozymes] [+ 4 isozymes] N-(3-aminopropyl) biotinyl-5'- HMPREF2590_RS19085 a 2-methylsulfanyl-N -L- (5Z,8Z,11Z,14Z,17Z) 3',5'-ADP a D-amino acid a [protein] (L-serine/L- (3Z)-dec-3- (3E)-undec- a pseudouridine 38- [acp] HMPREF2590_RS08940 HMPREF2590_RS11405 an unsulfurated AMP carboxyl-[aryl- carrier protein] tRNA pyruvate dehydrogenase dehydrogenase met 5'-deoxyadenosine threonylcarbamoyladenine 37 threonine) phosphate acetyl-CoA acetamide 3-sulfinoalanine adenylate 3-hydroxyacyl-ACP acetate kinase: carrier protein] -icosapentaenoyl-CoA enoyl-CoA 3-enoyl-CoA 40 in tRNA phosphatidylglycerol [+ 5 isozymes] Nucleoside and Nucleotide Biosynthesis D-erythrose E2 protein] N 6 E2 protein] N 6 -S- [sulfur carrier] dehydratase FabZ: HMPREF2590_RS11240 in tRNA biosynthesis II (non-plastidic) 4-phosphate F6P -dihydrolipoyl-lipoate acetyltransferase:acetyldihydrolipoyl- HMPREF2590_RS12465 stearoyl-CoA citrate degradation superpathway of guanosine nucleotides de novo biosynthesis II L-lysineHMPREF2590_RS05690L-lysine superpathway of pyrimidine ribonucleosides salvage transketolase: acetyl phosphate acetyl-CoA a (2E)-tetradec- DHAP superpathway of guanosine superpathway of adenosine nucleotides de novo biosynthesis II superpathway of inosine-5'-phosphate biosynthesis I 5-aminoimidazole ribonucleotide biosynthesis I Respiration 3-aci- cob(I)alamin- (5Z,8Z,11Z,14Z,17Z)-3- (-)-methyl MoO - (R)-3- HMPREF2590_RS19095 an acetyl-holo a (6S)-5- a [ThiI sulfur-carrier maltotriose 2 a DNA segment ethanol 2-enoyl-[acp] glycerol-3-phosphate nucleotides de novo biosynthesis I adenosine nucleotides nitropropanoate glu cys oxodocosapentaenoyl-CoA jasmonate hydroxybutanoate repressor LexA ser fatty acid elongation -- saturated transketolase: [citrate lyase acyl- citrate formyltetrahydrofolate [corrinoid ATP protein]-L-cysteine alpha-glucosidase: molybdopterin ATP dehydrogenase (NAD(P)(+) cytidine de novo biosynthesis I acetyl-CoA nitronate monooxygenase: cysteine desulfurase: 3-oxoacyl-[acyl-carrier- carboxylesterase: recombinase RecA: 3-hydroxybutyrate NAD(P)-dependent myristoyl-[acyl-carrier- IMP AIR PRPP 2-oxoglutarate decarboxylation to succinyl-CoA carrier protein] citrate lyase subunit beta: bifunctional adenosyltranferase] HMPREF2590_RS27845 cofactor serine dehydratase: ): HMPREF2590_RS16940 HMPREF2590_RS21010 HMPREF2590_RS23090 ATP:cob(I)alamin protein] reductase: HMPREF2590_RS22125 molybdenum cofactor HMPREF2590_RS04740 dehydrogenase: LexA repressor: alcohol dehydrogenase: protein] reductase: IMP asp IMP 5-(carboxyamino)imidazole a citryl-holo HMPREF2590_RS21445 D-gluconate degradation folylpolyglutamate synthase/ HMPREF2590_RS11295 sn-glycerol cytidine deaminase: D-glyceraldehyde phosphotransacetylase: nitronate monooxygenase: adenosyltransferase: alpha-glucosidase: carboxylesterase: guanylyltransferase: recombinase RecA: HMPREF2590_RS24025 HMPREF2590_RS04185 an acetoacetyl-[acp] asp IMP ribonucleotide synthase: amidophosphoribosyltransferase: a [2-oxoglutarate [citrate lyase acyl- dihydrofolate synthase: a [ThiI sulfur- [+ 2 isozymes] HMPREF2590_RS05100 HMPREF2590_RS06005 HMPREF2590_RS21050 HMPREF2590_RS23565 3-phosphate HMPREF2590_RS07350 3-phosphate adenosylcob(III)HMPREF2590_RS16800 HMPREF2590_RS05920 adenylyl HMPREF2590_RS27165 HMPREF2590_RS04745 [+ 3 isozymes] IMP dehydrogenase: HMPREF2590_RS28315 HMPREF2590_RS22465 dehydrogenase carrier protein] HMPREF2590_RS29470 HMPREF2590_RS16245 HMPREF2590_RS09210 ala (3R,5Z,8Z,11Z,14Z,17Z)-3- HMPREF2590_RS20810 adenylosuccinate adenylosuccinate D-gluconate [unspecified triphosphate alamin-[corrinoid carrier protein]-S- molybdenum a DNA segment in acetoacetate acetaldehyde glycerol-3-phosphate cytidine deaminase: 6 a (6S)-5- D-glucopyranose maltose cleaved pyruvate a myristoyl-[acp] HMPREF2590_RS08250 CMP IMP dehydrogenase: synthetase: N5-CAIR amidophosphoribosyltransferase: E2 protein] N phosphate degradation nitrite 3-oxopropanoate sulfanyl-L-cysteine hydroxydocosapentaenoyl-CoA MeOH (-)-jasmonate synthetase: 2-oxoglutarate citrate lyase subunit beta: gluconokinase: formyltetrahydrofolate adenosyltranferase] cofactor reverse orientation repressor LexA acyltransferase: HMPREF2590_RS09745 HMPREF2590_RS08250 HMPREF2590_RS28285 -lipoyl-L-lysine acetyltransferase: (d)CMP kinase: HMPREF2590_RS03810 HMPREF2590_RS03810 dehydrogenase HMPREF2590_RS21445 HMPREF2590_RS03020 products] 3-oxoacyl-[acyl-carrier- HMPREF2590_RS20610 adenylo-succinate 5-(carboxyamino)imidazole HMPREF2590_RS26580 XMP HMPREF2590_RS16895 5-phospho-β- gly 2-oxoglutarate E1 component: protein] reductase: glycerol-3-phosphate uridine ribonucleotide mutase: gluconokinase: adenylo-succinate D-ribosylamine dehydrogenase HMPREF2590_RS04005 oxaloacetate 6 a 3-oxoacyl-[acp] CDP XMP adenylosuccinate lyase: HMPREF2590_RS28320 HMPREF2590_RS19075 an O - a 2,3,4- 2-trans, 4-cis- a [release factor]- an organic HMPREF2590_RS05100 acyltransferase: E1 component: D-gluconate aci-nitroethane a [protein]- a sulfurated a [protein] (L-serine/L- pyridoxal a dipeptide DMKH2-11 xanthosine-5'-phosphate:L- inosine-uridine preferring HMPREF2590_RS28310 methylguanine hydrogen cyanide DL-allothreonine saturated (3R)-3- undecadienoyl- HMPREF2590_RS08825 6-phosphate L-cysteine ATP cob(II)inamide [sulfur carrier] threonine) phosphate L-glutamine molecule [+ 2 isozymes] glutamine amido- adenylosuccinate lyase: CAIR phosphoribosylamine- HMPREF2590_RS04005 oxalate degradation V nitronate monooxygenase: in DNA hydroxyacyl-CoA CoA peptide chain release a 1-acyl-sn nucleoside hydrolase: xanthosine-5'-phosphate:L- methylated-DNA-- rhodanese domain- serine protein phosphatase 2C 3-oxoacyl-[acyl-carrier- demethylmenaquinone cytochrome P450: a 3-oxohexadecanoyl- ligase (AMP-forming): uracil HMPREF2590_RS28310 -glycine ligase: [+ 3 isozymes] a [2-oxoglutarate a [2-oxoglutarate HMPREF2590_RS23090 ATP:cob(I)alamin factor N(5)-glutamine membrane dipeptidase: -glycerol 3- HMPREF2590_RS22145 glutamine amido- [protein]-cysteine S- containing protein: hydroxymethyltransferase: domain-containing protein: acetoacetyl-CoA reductase: 2,4-dienoyl-CoA reductase: protein] reductase: methyltransferase: HMPREF2590_RS18365 [acp] HMPREF2590_RS26055 phosphoribosyltransferase: AMP phosphoribosylaminoimidazolesuccinocarboxamide HMPREF2590_RS28265 dehydrogenase dehydrogenase oxalate adenosyltransferase: methyltransferase: HMPREF2590_RS04720 phosphate inosine-uridine preferring ligase (AMP-forming): nitronate monooxygenase: methyltransferase: HMPREF2590_RS09665 HMPREF2590_RS26220 HMPREF2590_RS14915 HMPREF2590_RS15980 HMPREF2590_RS05800 HMPREF2590_RS05100 HMPREF2590_RS16980 [+ 2 isozymes] HMPREF2590_RS26215 synthase: HMPREF2590_RS28305 E2 protein] N 6 E2 protein] N 6 -S- HMPREF2590_RS16800 an unsulfurated HMPREF2590_RS26280 3-oxoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- nucleoside hydrolase: HMPREF2590_RS26055 AMP cupin domain- HMPREF2590_RS16245 HMPREF2590_RS04545 uridine kinase: Alcohol Degradation [unspecified thiocyanate gly acetaldehyde a 2,3,4-saturated (3E)-undec- a [release factor]-N 5 4-pyridoxolactone a proteinogenic menaquinol-11 an alcohol phosphate acyltransferase: protein] synthase II: 3-ketoacyl-ACP reductase: GMP -dihydrolipoyl- succinyldihydrolipoyl- containing protein: glycerol and glycerophosphodiester degradation a [protein]-S- triphosphate adenosylcobinamide [sulfur carrier] a [protein] Ser/Thr protein] reductase: HMPREF2590_RS07745bifunctional pyrimidine HMPREF2590_RS14390 adenylate kinase: SAICAR GAR glycerol degradation V degradation nitrite acetaldehyde a guanine in DNA 3-oxoacyl-CoA 3-enoyl-CoA amino acid HMPREF2590_RS23435 HMPREF2590_RS18865 GMP L-lysine L-lysine HMPREF2590_RS13100 methyl-L-cysteine -methyl-L-glutamine HMPREF2590_RS05100 HMPREF2590_RS12485 [+ 2 isozymes] operon transcriptional HMPREF2590_RS08615 [+ 7 isozymes] nucleoside- adenylate kinase: phosphoribosylglycinamide formate products] [+ 7 isozymes] 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- regulator/uracil uracil a glycerophosphodiester guanylate kinase: diphosphate kinase: HMPREF2590_RS08615 adenylosuccinate lyase: formyltransferase: glycerol a (3R)-3- phosphate acyltransferase: protein] synthase II: HMPREF2590_RS05205 phosphoribosyltransferase: HMPREF2590_RS28310 a (3R)-3- HMPREF2590_RS16990 guanylate kinase: ADP glycerol dehydrogenase: a [2-oxoglutarate- a 5'-half-tRNA 2 4 747 HMPREF2590_RS28275 10 a dimer of non- trans-∆ , cis-∆ - a uracil (indol-3-yl) hydroxyhexadecanoyl- HMPREF2590_RS03160 a 2,3,4-saturatedHMPREF2590_RS12060 HMPREF2590_RS05300 2-oxoglutarate glycerol an N - a 3'-half-tRNA an unsulfurated a nucleoside DMK-12 butan-1-ol hydroxyacyl-[acyl- HMPREF2590_RS05205 glycerophosphodiester HMPREF2590_RS23160 dehydrogenase a sulfurated a pimeloyl-[acp] ala phe molecule with cys adjacent 2'- [acp] a 1,2-diacyl- fatty acyl-[acp] ADP AICAR dehydrogenase glycerol degradation II SAM dGTP formyltetrahydrofolate molecule with [sulfur carrier] hν decadienoyl-CoA in 23S rRNA acetamide triphosphate carrier protein] ribonucleoside- FGAR phosphodiesterase: dihydroxyacetone E2 protein] N 6 - [sulfur carrier] a 2',3'-cyclic deoxycytidines 23S rRNA 3-hydroxyacyl-ACP sn-glycerol 3-hydroxyacyl-ACP GDP E1 component: 8-amino-7- phenylalanine 4- a 5'-OH end cysteine desulfurase: amidase: nucleoside triphosphate demethylmenaquinone NAD(P)-dependent diphosphate reductase: glycerol kinase: HMPREF2590_RS19630 octanoyl-L-lysine dGTP triphosphohydrolase: phosphate end in DNA deoxyribodipyrimidine 2,4-dienoyl-CoA reductase: (uracil(1939)-C(5))- dehydratase FabZ: 3-phosphate dehydratase FabZ: GDP bifunctional phosphoribosylformylglycinamidine HMPREF2590_RS04005 lipoyl synthase: oxononanoate synthase: monooxygenase: 2'-5' RNA ligase: HMPREF2590_RS11295 HMPREF2590_RS15680 pyrophosphohydrolase: methyltransferase: alcohol dehydrogenase: UMP ribonucleotide-diphosphate ribonucleoside- HMPREF2590_RS16180 [+ 4 isozymes] glycerol dihydroxyacetone kinase: HMPREF2590_RS05800 methyltransferase RlmD: HMPREF2590_RS12465 phosphatidate phosphoribosylaminoimidazolecarboxamide HMPREF2590_RS13080 HMPREF2590_RS21540a [2-oxoglutarate HMPREF2590_RS22670 HMPREF2590_RS06450 HMPREF2590_RS07630 HMPREF2590_RS14330 [+ 2 isozymes] photo-lyase: [+ 2 isozymes] HMPREF2590_RS16980 HMPREF2590_RS23565 HMPREF2590_RS12465 reductase subunit beta: synthase: HMPREF2590_RS28290 dihydrolipoyllysine-residue HMPREF2590_RS23170 10 HMPREF2590_RS08095 diphosphate reductase: ribonucleotide-diphosphate glycerol dehydrogenase: 8-amino-7- 4a-hydroxy-N - a ligated tRNA a sulfurated HMPREF2590_RS02170 HMPREF2590_RS28090 cytidylyltransferase: formyltransferase/IMP cyclohydrolase: an unsulfurated dehydrogenase (2E)-dec-2- 747 a (2E)-hexadec- nucleoside- ribonucleoside- ribonucleotide-diphosphate (d)CMP kinase: HMPREF2590_RS16175 HMPREF2590_RS16180 HMPREF2590_RS28295 succinyltransferase: HMPREF2590_RS23160 2'-deoxyguanosine triphosphate acyl-carrier protein tyr ala a 2'-deoxycytidine a 5-methyluracil (indol-3-yl)acetate a nucleoside 5'- menaquinol-12 butan-1-al reductase subunit beta: sn-glycerol 5'-deoxyadenosine met 6 oxononanoate formyltetrahydrofolate with a 2'-5' linkage [sulfur carrier] HMPREF2590_RS04955 diphosphate kinase: diphosphate reductase: reductase subunit beta: HMPREF2590_RS16895 nucleoside- ribonucleoside- HMPREF2590_RS28270 HMPREF2590_RS28300 HMPREF2590_RS04010 DHAP [sulfur carrier] E2 protein] N in DNA enoyl-CoA 2-enoyl-[acp] ribonucleoside- ribonucleotide-diphosphate 3-phosphate dihydroxyacetone in 23S rRNA monophosphate a CDP- HMPREF2590_RS16990 HMPREF2590_RS16180 HMPREF2590_RS16175 [+ 2 isozymes] diphosphate kinase: diphosphate reductase: HMPREF2590_RS16175 Secondary Metabolite Degradation -lipoyl-L-lysine palmitoyl-[acyl-carrier- diphosphate reductase: reductase subunit beta: ATP FAICAR FGAM diacylglycerol HMPREF2590_RS16990 HMPREF2590_RS16180 glycerol-3-phosphate (R,R)-butanediol protein] reductase: ribonucleotide-diphosphate ribonucleoside- UDP HMPREF2590_RS16180 HMPREF2590_RS16175 dADP CDP-diacylglycerol-- bifunctional dehydrogenase: degradation reductase subunit beta: diphosphate reductase: ribonucleotide-diphosphate anhydromuropeptides recycling I a [pyruvate 10 a long-linear (6R)-L-erythro 2604 1498 HMPREF2590_RS04185 nucleoside- phosphoribosylformylglycinamidine (6Z,9Z,12Z,15Z,18Z,21Z)-3- (3R,7Z,10Z,13Z,16Z)-3- 4a-hydroxy-N - (11Z,14Z,17Z)-3- carbamoyl a uridine a (2E,4Z)- a uracil glycerol-3-phosphate 3- a trans-2- GTP HMPREF2590_RS16175 HMPREF2590_RS16180 reductase subunit beta: phosphoribosylaminoimidazolecarboxamide 2-oxoisovalerate decarboxylation to isobutanoyl-CoA HMPREF2590_RS13075 a sulfurated α-D-glucan DMKH2-13 butan-1-ol a 2,3,4-saturated dADP anaerobic ribonucleoside- nucleoside- cyclo-ligase: HMPREF2590_RS28280 (R,R)-2,3- dehydrogenase oxotetracosahexaenoyl-CoA hydroxydocosatetraenoyl-CoA formyltetrahydrofolate -5,6,7,8- phe oxoicosatrienoyl-CoA asp in 23S rRNA dienoyl-CoA in 16S rRNA diphosphate kinase: GlcNAc-1,6- DHAP SAM 6 glycogen/starch/alpha- phosphate a palmitoyl-[acp] phosphatidyltransferase: enoyl-[acyl- GTP HMPREF2590_RS16175 formyltransferase/IMP cyclohydrolase: E2 protein] N - [sulfur carrier] acetyl-CoA C- tetrahydrobiopterin 23S rRNA fatty acyl-[acp] HMPREF2590_RS16990 triphosphate reductase: diphosphate kinase: an [apo BCAA anhMurNAc- DHAP butanediol(R,R)-butanediol 4a-hydroxytetrahydrobiopterin phenylalanine 4- 3-oxoacyl-[acyl-carrier- aspartate 16S rRNA (uracil(1498)- demethylmenaquinone NAD(P)-dependent HMPREF2590_RS04755 carrier protein] HMPREF2590_RS28270 octanoyl-L-lysine acyltransferase: acetoacetyl-CoA reductase: glucan phosphorylase: pseudouridine(2604) 2,4-dienoyl-CoA reductase: HMPREF2590_RS20605 HMPREF2590_RS16990 AIR dehydrogenase γ lipoyl synthase: dehydratase: monooxygenase: protein] reductase: carbamoyltransferase: N(3))-methyltransferase: methyltransferase: alcohol dehydrogenase: 1-(3-sn- UTP L-Ala- -D-Glu- dehydrogenase: HMPREF2590_RS21680 HMPREF2590_RS15980 HMPREF2590_RS27680 HMPREF2590_RS05800 2,3,4-saturated fatty anaerobic ribonucleoside- dGDP E2 protein] N 6 HMPREF2590_RS21540a [pyruvate HMPREF2590_RS07635 α-D- HMPREF2590_RS07630 HMPREF2590_RS05100 HMPREF2590_RS05290 synthase RluF: HMPREF2590_RS07400 HMPREF2590_RS16980 HMPREF2590_RS23565 phosphatidyl) nucleoside- anaerobic ribonucleoside- branched-chain alpha- DAP-D-Ala HMPREF2590_RS25325 3 triphosphate reductase: dGDP IMP superpathway of pyrimidine deoxyribonucleoside salvage [+ 2 isozymes] 10 a long-linear (6R)-6,7- N-carbamoyl- HMPREF2590_RS02550 an N - acyl-[acp]:NAD+ diphosphate kinase: triphosphate reductase: dATP -lipoyl-L-lysine keto acid dehydrogenase: (R)-acetoin an unsulfurated dehydrogenase (7Z,10Z,13Z,16Z)-3- an N -formyl- glucopyranose tyr (3R,11Z,14Z,17Z)-3- 2604 a (3E)-3- -sn-glycerol CTP synthetase: 5'-deoxyadenosine met (4Z,7Z,10Z,13Z,16Z,19Z) α-D-glucan dihydrobiopterin L-aspartate a pseudouridine methyluracil 1498 menaquinol-13 butan-1-al oxidoreductase: HMPREF2590_RS20605 HMPREF2590_RS16990 HMPREF2590_RS03520 dihydrolipoyl [sulfur carrier] E2 protein] N 6 acetyl-CoA oxodocosatetraenoyl-CoA 7,8-dihydrofolate 1-phosphate hydroxyicosatrienoyl-CoA enoyl-CoA 3-phosphate HMPREF2590_RS26335 guanine and 2'-deoxycytidine HMPREF2590_RS14765 C1 Compound Utilization and Assimilation -docosahexaenoyl-CoA in 23S rRNA in 16S rRNA palmitate HMPREF2590_RS04185 anaerobic ribonucleoside- nucleoside- pyrimidine deoxyribonucleotides de novo biosynthesis I nucleoside- dehydrogenase: -lipoyl-L-lysine phosphatidylglycerophosphatase CTP synthase: guanosine salvage II triphosphate reductase: diphosphate kinase: diphosphate kinase: HMPREF2590_RS06675 N-acetyl-β-D- L-alanyl-γ-D- long-chain fatty A: HMPREF2590_RS21435 HMPREF2590_RS02365 UDP CTP HMPREF2590_RS16990 cytidine deaminase: 2'-deoxycytidine kinase: formate assimilation into 5,10- HMPREF2590_RS03520 HMPREF2590_RS16990 dATP [+ 2 isozymes] glucosamine-1,6- glutamyl-meso-2,6- a nascent peptidoglycan (2E,4E)- acid--CoA ligase: an L-1- ribonucleoside- nucleoside HMPREF2590_RS07350 HMPREF2590_RS08285 an [apo BCAA methylenetetrahydrofolate formaldehyde oxidation (6Z,9Z,12Z,15Z,18Z)-3- lipid II (meso an N-terminal L-alanyl-[S18 (4-hydroxyphenyl) a (2E,4E)- guanosine an [apo BCAA dehydrogenase anhydro-N-acetyl- diaminopimeloyl- γ N,N'-diacetylchitobiose 4-guanidinobutyramide tetradeca-2,4- DNA with lesion DMKH2-10 acetamide HMPREF2590_RS08940 phosphatidyl- triphosphatase YtkD: superpathway of pyrimidine adenine salvage cytidine deaminase: dehydrogenase II (glutathione-dependent) with (L-alanyl- -D-glutamyl- lipid II (meso oxotetracosapentaenoyl-CoA diaminopimelate protein of 30S ribosome] acetate a protein dienoyl-CoA diphosphate reductase: dGTP 6 β-D-muramate D-alanine chitin disaccharide 6 E2 protein] N -S-[2- meso-2,6-diaminopimeloyl-D- diaminopimelate containing) acetyl-CoA C- dienoyl-CoA excinuclease ABC: [+ 5 isozymes] sn-glycerol HMPREF2590_RS16180 HMPREF2590_RS27290 nucleobases salvage HMPREF2590_RS09745 dCMP E2 protein] N formate containing)peptidoglycan 4-hydroxyphenylacetate Xaa-Pro dipeptidyl- amidase: demethylmenaquinone amidase: methylpropanoyl]dihydrolipoyl- peptidoglycan acyltransferase: alanine acetyltransferase: deacetylase: 2,4-dienoyl-CoA reductase: HMPREF2590_RS22310 CTP CDP -dihydrolipoyl- formate-- formaldehyde alanyl-D-alanine) pentapeptide transglycosylase: 3-hydroxylase: peptidase: HMPREF2590_RS15680 2,4-dienoyl-CoA reductase: methyltransferase: HMPREF2590_RS09870 palmitoyl-CoA adenine and ribonucleotide-diphosphate uracil (d)CMP kinase: L-lysine transglycosylase: HMPREF2590_RS20760 HMPREF2590_RS22535 HMPREF2590_RS05800 purine deoxyribonucleosides salvage HMPREF2590_RS21680 β HMPREF2590_RS05800 HMPREF2590_RS22315 adenosine salvage I reductase subunit beta: uracil adenine 2'-deoxyuridine HMPREF2590_RS16895 L-lysine tetrahydrofolate ligase: HMPREF2590_RS25965a nascent peptidoglycan lipid II (meso di-trans,octa-cisHMPREF2590_RS25965 N-acetyl- -D- HMPREF2590_RS13745 HMPREF2590_RS14540 [+ 2 isozymes] HMPREF2590_RS16980 [+ 2 isozymes] ribonucleoside- guanine L-alanyl-γ-D- [+ 2 isozymes] [+ 4 isozymes] 1,6-anhydro-N- 10 HMPREF2590_RS00355 with (L-alanyl-γ-D-glutamyl- an N-terminal N-acetyl-L-alanyl- acetate glucosaminyl-(1->4) a (2E)-2- dGTP HMPREF2590_RS16175 diphosphate reductase: phosphoribosyltransferase: guanine and an N - di-trans,octa-cis- (4Z,7Z,10Z,13Z,16Z)- diaminopimelate -undecaprenyl 3,4-dihydroxyphenylacetate a peptide a dipeptide 4-guanidinobutanoate (3E)-tetradec- DNA without menaquinol-10 acetate dCDP β glutamyl-meso- S-(hydroxymethyl) acetyl-CoA [S18 protein of 30S ribosome] dUDP HMPREF2590_RS26215 guanosine salvage thymidine kinase: acetyl- -muramate formyltetrahydrofolate undecaprenyl diphosphate meso-2,6-diaminopimeloyl-D- containing) diphosphate -D-glucosamine 3-enoyl-CoA enoyl-CoA 2'-deoxyguanosine HMPREF2590_RS16180 adenine/guanine diaminopimelate glutathione docosapentaenoyl-CoA lesion 2'-deoxyadenosine adenosine xanthine and adenine deaminase: adenine HMPREF2590_RS26290 nucleoside- branched-chain alpha- anhydro-N-acetylmuramic alanyl-D-alanine) pentapeptide deoxynucleoside kinase: deoxynucleoside kinase: nucleoside- ribonucleotide-diphosphate bifunctional pyrimidine phosphoribosyltransferase: bifunctional glutathione-dependent purine-nucleoside xanthosine salvage HMPREF2590_RS01300 phosphoribosyltransferase: [+ 2 isozymes] thymidine diphosphate kinase: keto acid dehydrogenase: acid kinase: HMPREF2590_RS08290 HMPREF2590_RS08290 diphosphate kinase: reductase subunit beta: operon transcriptional guanosine HMPREF2590_RS21450 methylenetetrahydrofolate formaldehyde phosphorylase: HMPREF2590_RS07885 HMPREF2590_RS16990 HMPREF2590_RS14765 HMPREF2590_RS08835 HMPREF2590_RS16990 HMPREF2590_RS16175 regulator/uracil [+ 3 isozymes] dehydrogenase/ adenine 2503 (9Z,12Z,15Z,18Z,21Z)-3- 4-(γ-L-glutamylamino) deoxynucleoside kinase: deoxynucleoside kinase: HMPREF2590_RS06295 purine-nucleoside dUMP N-acetyl-D- dehydrogenase: isovalerate a 2-oxo 4-hydroxyphenylpyruvate 2-hydroxyisobutyramide palmitoleoyl-CoA DHAP a (2E,4E)- carbonic acid an aliphatic acrylamide xanthosine phosphoribosyltransferase: adenine/guanine thymidine kinase: dCTP methenyltetrahydrofolate in 23S rRNA oxotetracosapentaenoyl-CoA L-ornithine butanoate α ω HMPREF2590_RS08285 HMPREF2590_RS08285 purine-nucleoside dUTP dCDP phosphorylase: muramate 6- autoinducer AI-2 degradation HMPREF2590_RS01780 carboxylate dienoyl-CoA , -diamine HMPREF2590_RS05300 hypoxanthine phosphoribosyltransferase: GMP HMPREF2590_RS26290 23S rRNA acetate--CoA ligase: gamma-glutamyl-gamma- glycerol-3-phosphate carbonic anhydrase: dGMP dAMP phosphorylase: purine-nucleoside HMPREF2590_RS06295 thymidylate synthase: phosphate cyclohydrolase: ornithine--oxo-acid 4-hydroxyphenylpyruvate amidase: acyl-CoA dehydrogenase: spermidine N1- amidase: nucleoside triphosphate nucleoside- UMP HMPREF2590_RS21450 [+ 2 isozymes] S-formylglutathione (adenine(2503)-C(2))- acetoacetyl-CoA reductase: HMPREF2590_RS11405 aminobutyrate hydrolase: dehydrogenase (NAD(P)(+) 2,4-dienoyl-CoA reductase: HMPREF2590_RS02220 HMPREF2590_RS16725 phosphorylase: purine-nucleoside HMPREF2590_RS03180 N-acetylmuramic acid HMPREF2590_RS06775 transaminase: dioxygenase: HMPREF2590_RS15680 HMPREF2590_RS21675 acetyltransferase: HMPREF2590_RS15680 pyrophosphohydrolase: diphosphate kinase: adenine/guanine AI-2 methyltransferase RlmN: HMPREF2590_RS15980 HMPREF2590_RS23885 ): HMPREF2590_RS16940 HMPREF2590_RS05800 carbonic anhydrase: adenine HMPREF2590_RS16725 (d)CMP kinase: phosphorylase: 6-phosphate etherase: a 5,10- HMPREF2590_RS11935 HMPREF2590_RS12170 [+ 2 isozymes] [+ 8 isozymes] HMPREF2590_RS22050 [+ 2 isozymes] HMPREF2590_RS08095 HMPREF2590_RS16990 phosphoribosyltransferase: HMPREF2590_RS05170 isovaleryl-CoA AMP diphosphate L-glutamate-5- a proteinogenic HMPREF2590_RS27330 HMPREF2590_RS16895 HMPREF2590_RS16725 HMPREF2590_RS24545 autoinducer-2 kinase: methenyltetrahydrofolate (3R,9Z,12Z,15Z,18Z,21Z)-3- 4-aminobutanoate glu 2-hydroxy-2- (2E,9Z)- sn-glycerol a (3E)-3- an aliphatic N- purine-nucleoside HMPREF2590_RS21450 a 2-methyladenine 2503 semialdehyde amino acid homogentisate acrylate dUMP dCTP AMP superpathway of glyoxylate bypass and TCA TCA cycle N-acetyl-D- HMPREF2590_RS01070 5'-deoxyadenosine met hydroxytetracosapentaenoyl-CoA methylpropanoate hexadecenoyl-CoA 3-phosphate enoyl-CoA CO H O acetyl-diamine adenine phosphorylase: [+ 2 isozymes] guanine (4S)-4-hydroxy-5- bifunctional in 23S rRNA 2 2 [+ 3 isozymes] glucosamine phosphoribosyltransferase: thymidylate synthase: HMPREF2590_RS06295 UDP phosphooxypentane- methylenetetrahydrofolate formate dGDP dADP HMPREF2590_RS07885 xanthine adenine/guanine dTMP 6-phosphate HMPREF2590_RS03180 IMP acetyl-CoA 2,3-dione dehydrogenase/ nucleoside- phosphoribosyltransferase: N-acetylglucosamine-6- adenine/guanine adenine/guanine thymidylate kinase: methenyltetrahydrofolate peptidoglycan peptidoglycan a (1->4)- a dimer of dTMP diphosphate kinase: phosphate deacetylase: (9Z,12Z,15Z,18Z)-3- a [protein]- (7Z)- 3-amino-4- maltose nucleoside- nucleoside- phosphoribosyltransferase: HMPREF2590_RS21450 HMPREF2590_RS08225 cyclohydrolase: 2-oxoglutarate a [protein]-L-lysine tetrapeptide, tetrapeptide, pimeloyl-CoA ala α-D-glucan non-adjacent hν roseoflavin DHAP phytol phosphoribosyltransferase: HMPREF2590_RS16990 HMPREF2590_RS06130 oxotetracosatetraenoyl-CoA L-glutamine hexadecenoyl-CoA ATP hydroxybenzoate diphosphate kinase: diphosphate kinase: HMPREF2590_RS21450 thymidylate kinase: [+ 3 isozymes] HMPREF2590_RS06775 2-oxoglutarate ferredoxin protein-glutamine gamma- glycan chain 1 glycogen/starch/alpha- thymidines in DNA 5'-phosphate HMPREF2590_RS21450 dTDP oxaloacetate citrate synthase 3: 3-hydroxy-5- glycanL,D-transpeptidase: chain 2 8-amino-7- deoxyribodipyrimidine acyl-CoA dehydrogenase: arylamine N- maltose O- NAD(P)-dependent HMPREF2590_RS16990 HMPREF2590_RS16990 HMPREF2590_RS08225 D-glucosamine acetoacetyl-CoA reductase: glutamyltransferase: glucan phosphorylase: methylglyoxal synthase: UTP HMPREF2590_RS02725 phosphooxypentane- a 5,10- oxidoreductase HMPREF2590_RS21805 photo-lyase: bifunctional riboflavin acetyltransferase: xanthine 6-phosphate oxononanoate synthase: HMPREF2590_RS27680 HMPREF2590_RS21675 acetyltransferase: alcohol dehydrogenase: AMP dTDP GMP nucleoside- acetyl-CoA 2,4-dione subunit beta: HMPREF2590_RS15980 HMPREF2590_RS05660 kinase/FAD synthetase: HMPREF2590_RS11400 HMPREF2590_RS17080 phosphoribosyltransferase: CTP synthetase: malate:quinone citrate synthase: methylenetetrahydrofolate a protein with an peptidoglycan[+ 2 isozymes] HMPREF2590_RS06450 α-D- HMPREF2590_RS02170 [+ 8 isozymes] HMPREF2590_RS15240 HMPREF2590_RS23565 dGTP dATP diphosphate kinase: phosphoglucosamine HMPREF2590_RS04710 8-amino-7- a (1->4)- HMPREF2590_RS04890 6-O-acetyl-α-D- HMPREF2590_RS17250 HMPREF2590_RS26335 HMPREF2590_RS11025 3-hydroxy-5- a reduced (3R,9Z,12Z,15Z,18Z)-3- N 6 -(γ-glutamyl)- coenzyme A glucopyranose a thymidine in DNA (2E,7Z)- roseoflavin adenine 3-acetylamino-4- nucleoside- oxidoreductase: D-ala DAP-DAP α methylglyoxal phytenal HMPREF2590_RS16990 mutase: phosphonooxypentane- + oxononanoate -D-glucan glucopyranosyl- diphosphate kinase: CTP synthase: HMPREF2590_RS01035malate dehydrogenase: H ferredoxin [iron- CO succinyl-CoA hydroxytetracosatetraenoyl-CoA L-lysine crosslink crosslink 1-phosphate hexadecenoyl-CoA dinucleotide hydroxybenzoate HMPREF2590_RS23620 2,4-dione thiolase: 2 (1->4)-D-glucose HMPREF2590_RS16990 HMPREF2590_RS02365 dTTP HMPREF2590_RS11015 sulfur] cluster XMP D-glucosamine HMPREF2590_RS01080 dTTP CTP (S)-malate citrate 1-phosphate malate synthase A: DHAP 3-oxo-2-(cis-2'-pentenyl)- a single- a 1-phosphatidyl- keto- (2R,3S)-3- HMPREF2590_RS11825 bifunctional UDP-N- acetyl-CoA trans,octacis- a ferrocytochrome a peptidoglycan a lipid II 5-aminolevulinate wound RNA 3-ethylmalate macrocin cyclopentane-1-hexanoyl-CoA PRPP palmitoyl-CoA stranded RNA 1D-myo-inositol acetylglucosamine decaprenyl phosphate b peptidoglycan ammonium CO ATP phenylpyruvate isopropylmalate fumarate hydratase: acetyl-CoA C- decaprenyl-phosphate 5 polyribonucleotide 1-phosphatidylinositol 2 3-isopropylmalate aconitate hydratase AcnA: diphosphorylase/ acyl-CoA desaturase: 4-hydroxyphenylpyruvate 3-isopropylmalate macrocin O- L-histidine biosynthesis Amino Acid Biosynthesis acyltransferase: phosphoribosyltransferase: transglycosylase: nucleotidyltransferase: phosphodiesterase: porphobilinogen synthase: DNA/RNA helicase: dehydratase: L-lysine biosynthesis II superpathway of branched chain amino acid biosynthesis L-methionine salvage cycle I (bacteria and plants) L-isoleucine biosynthesis V L-tryptophan biosynthesis HMPREF2590_RS00725 HMPREF2590_RS20670 HMPREF2590_RS27910 carbamate kinase: dioxygenase: dehydrogenase: methyltransferase: glucosamine-1-phosphate HMPREF2590_RS25965 HMPREF2590_RS04880 HMPREF2590_RS04650 HMPREF2590_RS09185 HMPREF2590_RS22470 class II fumarate hydratase: HMPREF2590_RS21680 HMPREF2590_RS21260 di-trans,octa-cis D-myo-inositol HMPREF2590_RS27865 HMPREF2590_RS16420 HMPREF2590_RS04390 N-acetyltransferase GlmU: trans,octacis- a ferricytochrome a nucleoside a single- carbamoyl HMPREF2590_RS12170 HMPREF2590_RS16415 PRPP [+ 2 isozymes] palmitoleoyl-CoA a 1,2-diacyl- HMPREF2590_RS16425 pyruvate HMPREF2590_RS17995 HMPREF2590_RS08130 decaprenylphospho-β-D- b -undecaprenyl a peptidoglycan 1,2-cyclic (2-hydroxyphenyl) 2-methylbutanoate chorismate fumarate cis-aconitate 3-oxo-2-(cis-2'-pentenyl)- 5 diphosphate stranded RNA sn-glycerol phosphate porphobilinogen an unwound RNA (2S)-2- 2-oxovalerate tylosin asp thr met diphosphate phosphate acetate 2-oxoglutaramate N-acetyl-α-D- ribofuranose 5-phosphate isopropylmalate ATP aspartate kinase: acetate--CoA ligase: aconitate hydratase AcnA: cyclopentane-1-(3-oxooctanoyl)-CoA acetolactate synthase: anthranilate synthase: glyoxylate glucosamine phosphoribosyltransferase HMPREF2590_RS04845 bifunctional threonine HMPREF2590_RS11405 succinate dehydrogenase: HMPREF2590_RS20670 HMPREF2590_RS16395 2-oxoglutaramate amidase: 2-methylbutanoyl- HMPREF2590_RS04105 1-phosphate regulatory subunit: ammonia-lyase/L-serine S-adenosylmethionine HMPREF2590_RS08985 aspartate kinase: HMPREF2590_RS16400 HMPREF2590_RS06025 CoA 3-oxo-2-(cis-2'-pentenyl)- orotidine 5'- (5Z)- (5Z)- HMPREF2590_RS16430 ammonia-lyase TdcB: synthase: HMPREF2590_RS08990 bifunctional UDP-N- acetyl-CoA isobutanoate an N-modified an alkylated DNA [EntF L-seryl- butanoyl-CoA phosphate prephenate [DNA] ethanol arsenate HMPREF2590_RS09410 [+ 2 isozymes] anthranilate isocitrate lyase: cyclopentane-1-butanoyl-CoA coenzyme A phosphate tetradecenoyl-CoA dodecenoyl-CoA ATP L-aspartyl- HMPREF2590_RS23035 HMPREF2590_RS27190 acetylglucosamine acetyl-CoA C- aminoacyl-[tRNA] DNA-3-methyladenine carrier protein] 2-oxoglutarate HMPREF2590_RS11830 acetate--CoA ligase: phosphate orotate acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: DNA polymerase/3'- catalase: arsenate reductase 4-phosphate diphosphorylase/ aminoacyl-tRNA hydrolase: glycosylase: holo-ACP synthase: prephenate dehydratase: phosphoribosyltransferase: (S)-2-acetolactate [+ 3 isozymes] anthranilate succinate D-threo-isocitrate acyltransferase: HMPREF2590_RS11405 butyryltransferase: HMPREF2590_RS21675 HMPREF2590_RS21675 5' exonuclease PolX: (thioredoxin): NADP-dependent glucosamine-1-phosphate HMPREF2590_RS08120 HMPREF2590_RS12120 phosphoribosyltransferase: HMPREF2590_RS01285 HMPREF2590_RS16435 (S)-3-methyl-2- phosphoribosyltransferase: HMPREF2590_RS21680 HMPREF2590_RS24275 a holo-[EntF HMPREF2590_RS09320 aspartate-semialdehyde ketol-acid (2Z)-2-aminobut- 4-(methylsulfanyl)-2-oxobutanoate SAM an N-modified an uncharged a DNA containing HMPREF2590_RS06690 HMPREF2590_RS05255 [+ 8 isozymes] [+ 8 isozymes] HMPREF2590_RS10820 [+ 2 isozymes] HMPREF2590_RS18230 HMPREF2590_RS04095 isocitrate dehydrogenase: N-acetyltransferase GlmU: [+ 2 isozymes] isobutanoyl-CoA AMP an alkylated 3',5'-ADP L-seryl-carrier butanoyl 1-(5-phospho- dehydrogenase: 2-enoate oxopentanoate succinyl-CoA succinate diphosphate amino acid tRNA an apurinic/ orotate PRPP (2E,5Z)- (2E,5Z)- keto- reductoisomerase: HMPREF2590_RS11020 HMPREF2590_RS08130 3-oxo-2-(cis-2'-pentenyl)- nucleobase phosphate a nucleoside 5'- acetaldehyde arsenite β-D-ribosyl)-ATP HMPREF2590_RS02355 branched-chain-amino- N-(5-phosphoribosyl) ligase subunit beta: apyrimidinic site protein] tetradecenoyl-CoA dodecenoyl-CoA HMPREF2590_RS16405 UDP-N-acetyl- cyclopentane-1-(3-oxohexanoyl)-CoA phenylpyruvate monophosphate phosphoribosyl-ATP acid transaminase: -anthranilate HMPREF2590_RS05025 aspartate-semialdehyde ketol-acid adenosylmethionine α-D-glucosamine pyrophosphatase: HMPREF2590_RS16390 phosphoribosylanthranilate dehydrogenase: reductoisomerase: UDP-N-acetylglucosamine 2-iminobutanoate decarboxylase: isomerase: a 2,3,4-saturated N-acetyl-D- HMPREF2590_RS16470 HMPREF2590_RS04850 HMPREF2590_RS09560 branched-chain-amino- succinyl-CoA 2-oxoglutarate cob(I)yrinate a,c- an (R)-2- 3-[(5'-methylthio) HMPREF2590_RS10970 HMPREF2590_RS04085 1-carboxyvinyltransferase: L-carnitine an L-cysteinyl- cis-vaccenoyl-CoA a β-lactam MeOH DMKH acid transaminase: halocarboxylate CTP 1,2-diacyl-sn- VibB coenzyme A galactosamine leu 2 phosphoribosyl-ATP L-aspartate- (2R)-2,3- HMPREF2590_RS22970 Fatty Acid and Lipid Degradation ATP diamide-[corrinoid [tRNA Cys ] pentyl]malate L-arginine biosynthesis I (via L-ornithine) HMPREF2590_RS09545 1-(o- carnitine-CoA ligase: HAD family hydrolase: glycerol 3-phosphate 6-phosphate pyrophosphohydrolase: semialdehyde dihydroxy-3- 1,2-dihydroxy-5- D-fructuronate degradation adenosyltranferase] phosphatidate holo-ACP synthase: N-acetylglucosamine-6- aminoacyl-tRNA hydrolase: acyl-CoA dehydrogenase: 3-isopropylmalate catalase: demethylmenaquinone dAdoMet carboxyphenylamino) UDP-N-acetylglucosamine ATP:cob(I)alamin HMPREF2590_RS08235 HMPREF2590_RS03200 MBL fold metallo-hydrolase: HMPREF2590_RS15695 methylbutanoate (methylsulfanyl)pent-1-en-3-one β cytidylyltransferase: HMPREF2590_RS12120 phosphate deacetylase: HMPREF2590_RS08120 HMPREF2590_RS21675 dehydrogenase: leucine dehydrogenase: HMPREF2590_RS01285 methyltransferase: 4-hydroxy- ile -1'-deoxyribulose 1-carboxyvinyltransferase: fatty acid -oxidation I adenosyltransferase: [+ 6 isozymes] HMPREF2590_RS02460 1-(5-phospho-β- 2,3-dihydroxy- 2-oxoglutarate D-fructuronate HMPREF2590_RS04955 a holo-[VibB aryl- HMPREF2590_RS06130 [+ 8 isozymes] HMPREF2590_RS16415 HMPREF2590_RS06685 [+ 2 isozymes] HMPREF2590_RS16980 tetrahydrodipicolinate 2-oxobutanoate glu putrescine 5'-phosphate HMPREF2590_RS26315 HMPREF2590_RS16800adenosyl- diphosphate AMP L-carnitinyl-CoA an (S)-2- a CDP-2,3,4-saturated- 3',5'-ADP D-galactosamine a tRNA Cys cys D-ribosyl)-AMP isovalerate dehydratase: 2-hydroxy-3-keto-5- dehydrogenase a [corrinoid a halide anion carrier protein] acetate (2E,11Z)- a substituted 8-(methylthio)- 4-methyl-2- synthase: indole-3-glycerol UDP-N-acetyl-α- mannonate oxidoreductase: a (3Z)-alk-3- triphosphate cobyrinate hydroxycarboxylate diacylglycerol 6-phosphate formaldehyde MQH HMPREF2590_RS09565 methylthiopentenyl-1- spermidine synthase: E1 component: adenosyltransferase] octadecenoyl-CoA β-amino acid 2-oxooctanoate 2 phosphoribosyl-AMP acetolactate synthase: bifunctional glutamate phosphate synthase TrpC: D-glucosamine- HMPREF2590_RS19580 enoyl-CoA a,c-diamide oxopentanoate HMPREF2590_RS14680 phosphate phosphatase: HMPREF2590_RS26500 cyclohydrolase: 3-methyl-2- HMPREF2590_RS16395 N-acetyltransferase/ HMPREF2590_RS04090 HMPREF2590_RS04005 D-mannonate 4-hydroxy- HMPREF2590_RS06040 spermidine enolpyruvate HMPREF2590_RS16465 oxobutanoate HMPREF2590_RS16400 amino-acid (1S,2R)-1-C-(indol-3- UDP-N- a dimer of adjacent 1-(5-phospho-β-D-ribosyl)- tetrahydrodipicolinate [+ 2 isozymes] phosphatidylglycerophosphate an oxidized an (S)-2- methyl β-D-glucoside (7Z)- 3-[(7'-methylthio) a [protein]-L- acetyltransferase ArgJ: long-chain fatty a ferrocytochrome (S)-4-amino-5- glu 2-phosphoglycolate synthase: 2-hydroxy-5-(methylsulfanyl)- yl)glycerol 3-phosphate acetylenolpyruvoylglucosamine a 2,3,4-saturated ammonium H O ferredoxin [iron- halocarboxylate stearoyl-CoA a tRNA thymidine and 2'- hν 6-phosphate ethylphosphate propionamide ω 5-[(5-phosphoribosylamino) 2-isopropylmalate branched-chain-amino- (S)-2-aceto-2- HMPREF2590_RS06515 S-methyl-5'-thioadenosine coenzyme A acid--CoA ligase: a (2E)-2- (1-octadecenoyl(9Z), 2-palmitoyl) 2 b oxopentanoate tetradecenoyl-CoA heptyl]malate proline ( = 180) HMPREF2590_RS04840 reductase: fatty acid sulfur] cluster HAD family hydrolase: 5 deoxycytidine in DNA 6-phospho-beta- methylideneamino]imidazole- synthase: acid transaminase: 3-oxopent-1-enyl 1-phosphate 5'-methylthioadenosine/ tryptophan synthase: enoyl-CoA enoyl-CoA hydratase: ferredoxin-- acyl-CoA desaturase: glutamyl-tRNA reductase: deoxyribodipyrimidine acyl-CoA dehydrogenase: phosphoglycolate 3-isopropylmalate acid phosphatase: amidase: peptidylprolyl (2S,4S)-4- hydroxybutanoate N-acetyl-L- HMPREF2590_RS22000 2-dehydro-3- HMPREF2590_RS19275 phosphatidylglycerophosphatase HMPREF2590_RS03200 glucosidase: 4-carboxamide HMPREF2590_RS16410 HMPREF2590_RS16390 S-adenosylhomocysteine HMPREF2590_RS04075 deoxy-D-gluconate HMPREF2590_RS21685 nitrite reductase: HMPREF2590_RS27910 HMPREF2590_RS09165 photo-lyase: HMPREF2590_RS21675 phosphatase: dehydrogenase: HMPREF2590_RS24580 HMPREF2590_RS15680 isomerase: prsA hydroxy-2,3,4,5- ketol-acid glutamate 2,3-diketo-5- L-arginine biosynthesis II (acetyl cycle) [+ 5 isozymes] acyl-CoA dehydrogenase: A: HMPREF2590_RS21435 [+ 6 isozymes] HMPREF2590_RS22540 nucleosidase: HMPREF2590_RS04080 UDP-N- a 2,3,4- HMPREF2590_RS16530 HMPREF2590_RS02170 [+ 8 isozymes] HMPREF2590_RS03265 HMPREF2590_RS16415 [+ 2 isozymes] [+ 4 isozymes] 1-(5-phosphoribosyl)-5- tetrahydrodipicolinate branched-chain-amino- reductoisomerase: an (S)-2- a ferricytochrome an L-glutamyl- β-D-glucose [+ 2 isozymes] methylthiopentyl-1- HMPREF2590_RS07710 acetylenolpyruvoylglucosamine HMPREF2590_RS21675 saturated (3R)-3- a halide anion oleoyl-CoA Glu adjacent thymidine-2'- MeOH ((5- phosphoribosylamino) (2S)-2- acid transaminase: HMPREF2590_RS16405 acetylglutamate kinase: N-acetylglutamyl- tryptophan synthase 1-oleoyl-2-palmitoyl- nitrite hydroxycarboxylate b [tRNA ] 6-phosphate (2E,7Z)- 10-(methylthio)- a [protein]-L- 4-hydroxy- phosphate enolase: [+ 8 isozymes] a 2,3,4- 5 deoxycytidine in DNA glycolate ethanol propanoate methylideneamino) isopropylmalate HMPREF2590_RS14750 [+ 3 isozymes] subunit beta: reductase: hydroxyacyl-CoA phosphatidylglycerol tetradecenoyl-CoA 2-oxodecanoate proline (ω = 0) tetrahydrodipicolinate HMPREF2590_RS09545 ketol-acid HMPREF2590_RS06035 phosphate a 2,3,4-saturated imidazole-4- HMPREF2590_RS05390 saturated (3S)-3- reductase: 3-isopropylmalate reductoisomerase: acetylglutamate kinase: N-acetyl-gamma-glutamyl- HMPREF2590_RS04080 KDGP fatty acyl CoA carboxamide isomerase: UDP-N-acetyl- hydroxyacyl-CoA HMPREF2590_RS17075 dehydratase: HMPREF2590_RS09560 HMPREF2590_RS06510 phosphate reductase: ser 3-hydroxyacyl-CoA 5-(methylsulfanyl)-2,3- acetylglutamate kinase: indole α-D-muramate UDP-N-acetyl-α-D-muramoyl- a dimer of non-adjacent a linear malto- a β-Gal-(1->3)-α-Gal-(1->2) salicin 6- a dimer of adjacent uridine 746 3-[(6'-methylthio) (indol-3- HMPREF2590_RS16455 HMPREF2590_RS16420 val MTR HMPREF2590_RS06520 dehydrogenase: D-alanyl-D-alanine GSSH sulfite oleoyl-CoA D-glycerate formamide (S)-2,3,4,5- (R)-2,3-dihydroxy- N-acetylglutamyl- dioxopentyl 1-phosphate S-methyl-5- HMPREF2590_RS14750 L-alanyl-γ-D-glutamyl-L-lysine thymidine and 2'- hν oligosaccharide -[α-(1->6)-oligomannan] phosphate 2'-deoxycytidine and hν HMPREF2590_RS16425 HMPREF2590_RS26365 in 23S rRNA hexyl]malate yl)pyruvate phosphoribulosylformimino- tetrahydrodipicolinate phosphate thioribose kinase: deoxycytidine in DNA glycogen/starch/alpha- polysaccharide pyruvyl 6-phospho-beta- thymidine in DNA rhodanese domain- 3-methylpentanoate acetylglutamate kinase: D-glyceraldehyde UDP-N-acetylmuramoyl- deoxyribodipyrimidine deoxyribodipyrimidine acyl-CoA dehydrogenase: 23S rRNA pseudouridine 3-isopropylmalate D-glycerate indolepyruvate AICAR-phosphate methylthioribulose 1- HMPREF2590_RS06020 tryptophan synthase pyruvate a 2,3,4-saturated a 2,3,4-saturated glucan phosphorylase: transferase CsaB: glucosidase: containing protein: formamidase: 2,3,4,5-tetrahydropyridine- 2-isopropylmaleate 2,3-dihydroxy-3- N-acetyl-gamma-glutamyl- HMPREF2590_RS06510 3-phosphate tripeptide--D-alanyl- photo-lyase: photo-lyase: HMPREF2590_RS21675 synthase F: dehydrogenase: dehydrogenase: decarboxylase: phosphate dehydratase: subunit beta: UDP-N-acetyl- fatty acyl CoA 3-oxoacyl-CoA HMPREF2590_RS27680 HMPREF2590_RS22540 HMPREF2590_RS09665 amiF 2,6-dicarboxylate N- methylvalerate hydro-lyase: phosphate reductase: S-methyl-5- D- alanine ligase: HMPREF2590_RS02170 HMPREF2590_RS15720 β HMPREF2590_RS02170 [+ 8 isozymes] HMPREF2590_RS10805 HMPREF2590_RS16415 HMPREF2590_RS21155 HMPREF2590_RS24210 HMPREF2590_RS04080 α α-D-glucopyranose a linear malto- β α -D-glucose 3-isopropylmalate HMPREF2590_RS06045 thioribose kinase: -D-muramoyl- a 2'-deoxycytidine a 4,6-CH (COO-)C- -Gal-(1->3)- - adjacent 2'-deoxycytidine- 746 imidazole glycerol acetyltransferase: HMPREF2590_RS09565 HMPREF2590_RS06520 HMPREF2590_RS12140 a thymidine in DNA 3 salicyl alcohol thiosulfate glutathione (2E,9Z)- a pseudouridine 9-(methylthio)- (indol-3-yl) N-acetyl-L- L-alanyl-γ-D- UDP-N-acetyl-α-D-muramoyl-L-alanyl- 1-phosphate oligosaccharide α 6-phosphate hydroxypyruvate formate phosphate synthase: HMPREF2590_RS05750 dehydratase: N-acetyl-L- HMPREF2590_RS28020 N-acetyl-L- in DNA Gal-(1->2)-[ -(1->6)-oligomannan] thymidine in DNA octadecenoyl-CoA in 23S rRNA 2-oxononanoate acetaldehyde (S)-3-methyl-2- glutamate 5- glutamyl-meso-2,6- γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine HMPREF2590_RS16450 HMPREF2590_RS16420 glutamate 5- glu glutamate acetyl-CoA C- 2,3,4,5-tetrahydropyridine- oxopentanoate bifunctional glutamate semialdehyde trp diaminopimelate HMPREF2590_RS16460 HMPREF2590_RS16425 semialdehyde 5-(methylthio)ribulose 1-phosphate 5-MTR-1-P acyltransferase: 2,6-dicarboxylate N- branched-chain-amino- N-acetyltransferase/ (2R,3S)-3- acetylornithine acetylornithine HMPREF2590_RS21680 a [formate C a dimer of non-adjacent a peptide with an (S)-2- a dimer of adjacent (R)-N-formyl-β- 3-amino-4- 3-[(4'-methylthio) a (1->4)- imidazole glycerol acetyltransferase: acid transaminase: amino-acid acetyl-CoA a reduced a [protein]-L-glutamine serotonin 2,2-dichloroacetate D-glycerate methylglyoxal isopropylmalate aminotransferase: aminotransferase: SAM acetyltransferase]- 2'-deoxycytidine and hν an N-terminal halocarboxylate pyrimidine hν hydroxy-L-kynurenine hydroxybenzaldehyde butyl]malate α-D-glucan phosphate synthase: HMPREF2590_RS22280 Nucleoside and Nucleotide Degradation [+ 2 isozymes] flavodoxin HMPREF2590_RS16390 HMPREF2590_RS01280 acetyltransferase ArgJ: HMPREF2590_RS01280 glycine thymidine in DNA protein-glutamine gamma- Xaa-L-proline haloacid dehalogenase: nucleosides in DNA arylformamidase: 1,4-alpha-glucan HMPREF2590_RS16355 3-isopropylmalate pyruvate formate lyase- deoxyribodipyrimidine leucyl aminopeptidase: deoxyribodipyrimidine arylamine N- 3-isopropylmalate D-glycerate glyoxalase: branched-chain-amino- HMPREF2590_RS06515bifunctional glutamate HMPREF2590_RS21460 VOC family protein: L-2-acetamido-6- acetylornithine acetylornithine activating protein: photo-lyase: glutamyltransferase: photo-lyase: HMPREF2590_RS15050 acetyltransferase: dehydrogenase: dehydrogenase: HMPREF2590_RS07640 branching protein GlgB: dehydrogenase: N-acetyltransferase/ superpathway of pyrimidine HMPREF2590_RS21270 HMPREF2590_RS17530 D-erythro- oxoheptanedioate acid transaminase: transaminase: S-methyl-5-thioribose-1- superpathway of purine deoxyribonucleosides degradation HMPREF2590_RS00855 HMPREF2590_RS05660 a peptide with [+ 7 isozymes] (R)-β-hydroxy- HMPREF2590_RS15240 HMPREF2590_RS16415 HMPREF2590_RS21155 HMPREF2590_RS27700 HMPREF2590_RS16415 gln amino-acid transaminase: deoxyribonucleosides degradation a [formate C HMPREF2590_RS02170 a [protein] N 6 -[(5-hydroxy-1H a proteinogenic an (R)-2- HMPREF2590_RS02170 formate [+ 5 isozymes] AICAR imidazole-glycerol- HMPREF2590_RS09545 HMPREF2590_RS06505 phosphate isomerase: a flavodoxin a 2'-deoxycytidine an N-terminal a halide anion two adjacent pyrimidine L-kynurenine (2S)-2-isopropyl- acetyltransferase ArgJ: HMPREF2590_RS06505 met 5'-deoxyadenosine acetyltransferase]- a thymidine in DNA -indol-3-yl)ethyl]-L-glutamine amino acid hydroxyacid 3-acetylamino-4- 7-(methylthio)-2- a glycogen phosphate HMPREF2590_RS28015 2'-deoxycytidine semiquinone in DNA L-proline nucleosides in DNA glyoxylate hydroxypyruvate (R)-lactate 3-oxosuccinate N-acetyl-L- HMPREF2590_RS06515carbamoyl- glycin -2-yl radical hydroxybenzaldehyde oxoheptanoate ile S-methyl-5-thioribose-1- superpathway of sulfate assimilation and cysteine biosynthesis 2'-deoxyguanosine imidazoleglycerol- ornithine L-proline biosynthesis I phosphate synthase: N-acetyl-L- phosphate isomerase: cytidine deaminase: phosphate N-acetyl-L,L-2,6- HMPREF2590_RS05275 ornithine 2'-deoxyadenosine acetylornithine HMPREF2590_RS07350 D-cellobiose a 7,8-dihydro-8- an (R)-2- a dimer of non- 3-[(3'-methylthio) a supercoiled a (1->4)- dehydratase diaminopimelate HMPREF2590_RS06015 HMPREF2590_RS05280 3-phospho-D-glycerate O-acetyl-L- leukotriene-D4 uroporphyrinogen-I putrescine an alcohol hydrogencarbonate methanethiol O-acetyl-L-serine hydrogen selenide 6'-phosphate oxoguanine in DNA halocarboxylate adjacent pyrimidine hν propyl]malate duplex DNA α-D-glucan HisB: hisB N-acetyldiaminopimelate 4-methyl-2- deacetylase: glu cytidine deaminase: thymidine homoserine HMPREF2590_RS00770 carbamoyl L-ornithine 3-phosphoglycerate purine-nucleoside O-acetylhomoserine 6-phospho-beta- DNA-formamidopyrimidine HAD family hydrolase: nucleosides in DNA deoxyribodipyrimidine membrane dipeptidase: uroporphyrinogen spermidine N1- 3-isopropylmalate replicative DNA helicase: NAD(P)-dependent 1,4-alpha-glucan imidazole acetol- deacetylase: oxopentanoate carbamoyl- glutamate 5-kinase: HMPREF2590_RS09745 cysteine synthase: phosphate dehydrogenase: pyrimidine- phosphorylase: aminocarboxypropyltransferase: glucosidase: glycosylase: HMPREF2590_RS03200 photo-lyase: HMPREF2590_RS04720 decarboxylase: acetyltransferase: dehydrogenase: HMPREF2590_RS23860 alcohol dehydrogenase: branching protein GlgB: phosphate HMPREF2590_RS05745 branched-chain-amino- phosphate synthase: acetylornithine HMPREF2590_RS01115 HMPREF2590_RS14185 L-N δ -acetylornithine biosynthesis γ-L-glutamyl HMPREF2590_RS18480 nucleoside HMPREF2590_RS06295 HMPREF2590_RS26675 HMPREF2590_RS22540 HMPREF2590_RS10990 [+ 6 isozymes] HMPREF2590_RS02170 HMPREF2590_RS11605 HMPREF2590_RS22050 HMPREF2590_RS16415 [+ 4 isozymes] HMPREF2590_RS23565 HMPREF2590_RS27700 acid transaminase: HMPREF2590_RS05275 deacetylase: 2'-deoxyuridine D-glucopyranose an apurinic site 7,8-dihydro- an (R)-2- leukotriene-E4 gly histidinol-phosphate L,L- phosphorylase: purine-nucleoside acetate L-selenocysteine D-glucopyranose a halide anion a pyrimidine L-proline biosynthesis III HMPREF2590_RS05280 HMPREF2590_RS02900 5-phosphate acetate met 6-phosphate within DNA 8-oxoguanine hydroxyacid 6-(methylthio)- a single starch transaminase: diaminopimelate HMPREF2590_RS16390 3-phosphooxypyruvate phosphorylase: nucleoside in DNA coproporphyrinogen I N-acetylputrescine an aldehyde glutamate-5-semialdehyde deoA purine-nucleoside 2'-deoxyinosine 2-oxohexanoate stranded DNA HMPREF2590_RS14130 branched-chain-amino- carbamoyl glu HMPREF2590_RS16725 diaminopimelate L-ornithine pro dehydrogenase: ornithine 3-phosphoserine pyrimidine- phosphorylase: histidinol-phosphate acid transaminase: glu phosphate epimerase: HMPREF2590_RS01110 carbamoyltransferase: aminotransferase: nucleoside HMPREF2590_RS06295 transaminase: HMPREF2590_RS09545 10 a 2-deoxy-D- (indole-3-yl) a monocarboxylic (2R,3S)-3- HMPREF2590_RS21335 proline dehydrogenase: glutamate 5-kinase: HMPREF2590_RS27875 HMPREF2590_RS18485 phosphorylase: purine-nucleoside purine-nucleoside an N - an L-methionyl- F6P 2-oxobutanoate 2-succinylbenzoate coenzyme A a nucleobase glutathione citrate spermidine pyrazinamide pullulan ornithine L-glutamate-5- Met ribosyl-base a type IV prepilin acetonitrile acid amide isopropylmalate HMPREF2590_RS17005 glutamate 5-kinase: HMPREF2590_RS21700 HMPREF2590_RS01115 deoA phosphorylase: formyltetrahydrofolate [initiator tRNA ] meso- leu semialdehyde pyrimidine- phosphorylase: fructose-6- branched-chain alpha- o-succinylbenzoate- nucleoside 2- VOC family protein: amidase: HMPREF2590_RS01115 carbamoyltransferase: inosine 5'-phosphate methionyl-tRNA prepilin peptidase: amidase: spermidine N1- 3-isopropylmalate pullulanase: L-histidinol diaminopimelate proline dehydrogenase: γ-L-glutamyl 3-phospho-L-serine nucleoside HMPREF2590_RS16725 HMPREF2590_RS06295 phosphate aldolase: keto acid dehydrogenase: -CoA ligase: deoxyribosyltransferase: HMPREF2590_RS17530 aconitate hydratase AcnA: HMPREF2590_RS27875 thymine degradation formyltransferase: HMPREF2590_RS15930 (glutathion-S- HMPREF2590_RS15680 acetyltransferase: dehydrogenase: HMPREF2590_RS15680 phosphate γ HMPREF2590_RS12850 phosphorylase: HMPREF2590_RS25345 HMPREF2590_RS14765 HMPREF2590_RS27620 HMPREF2590_RS13885 HMPREF2590_RS20670 HMPREF2590_RS06730 diaminopimelate -L-glutamyl L-ornithine 5-phosphate purine-nucleoside an N-formyl- HMPREF2590_RS05180 a cleaved type [+ 2 isozymes] HMPREF2590_RS22050 HMPREF2590_RS16415 [+ 2 isozymes] deoA D-glyceraldehyde 4-(2'-carboxyphenyl) a 2-deoxy-D- yl)(1H-indol-3- decarboxylase: 5-phosphate (S)-1-pyrroline- phosphorylase: dihydroxyacetone NADH CO propanoyl-CoA a nucleobase a peptide 8 histidinol-phosphatase: L-methionyl- a tetrahydrofolate 2 -4-oxobutyryl-CoA IV prepilin yl)acetonitrile N - 4-methyl-2- pyrazine-2- maltotriose 5-carboxylate pyrimidine- HMPREF2590_RS16725 IMP 3-phosphate ribosyl-base D-threo-isocitrate a monocarboxylate HMPREF2590_RS16475 HMPREF2590_RS16505 L-citrulline glutamate-5-semialdehyde (S)-1-pyrroline- L-citrulline [initiator tRNA met ] acetylspermidine oxopentanoate carboxylate nucleoside L-homoserine biosynthesis glutamate-5-semialdehyde ornithine--oxo-acid dehydrogenase: 5-carboxylate IMP dehydrogenase: lys phosphorylase: 2-deoxy-α-D- histidinol dehydrogenase: transaminase: argininosuccinate synthase: HMPREF2590_RS01110 pyrroline-5- argininosuccinate synthase: ser HMPREF2590_RS08250 deoA ribose 1-phosphate a ring-opened 7- a plant soluble a dimer of adjacent 2'- arbutin-6- 4-hydroxy- HMPREF2590_RS01110 HMPREF2590_RS11935 HMPREF2590_RS11205 carboxylate reductase: HMPREF2590_RS11205 a glycogen methyl red hν glutathione porphobilinogen spermine spermidine an arylamine (S)-malate chitosan asp guanosine nucleotides XMP methylguanine in DNA heteroglycan deoxycytidines in DNA phosphate 2-nonenal histidinol dehydrogenase: L-glutamate-5- HMPREF2590_RS23495 serine O-acetyltransferase: phosphopentomutase: aspartate kinase: L-arginino- L-arginino- degradation III DNA-formamidopyrimidine glycogen/starch/alpha- glycogen/starch/alpha- FMN-dependent deoxyribodipyrimidine 6-phospho-beta- VOC family protein: hydroxymethylbilane spermidine N1- spermidine N1- arylamine N- malate:quinone HMPREF2590_RS16440 L-glutamate-5- semialdehyde [+ 3 isozymes] HMPREF2590_RS08400 HMPREF2590_RS06300 chitosanase: HMPREF2590_RS04845 succinate succinate glycosylase: glucan phosphorylase: glucan phosphorylase: NADH-azoreductase 2: photo-lyase: glucosidase: HMPREF2590_RS17530 acetyltransferase: acetyltransferase: arg bifunctional (glutathion-S- synthase: acetyltransferase: oxidoreductase: HMPREF2590_RS15435 semialdehyde argininosuccinate lyase: 2-deoxy-D-ribose HMPREF2590_RS10990 HMPREF2590_RS27680 HMPREF2590_RS27680 HMPREF2590_RS03165 HMPREF2590_RS02170 HMPREF2590_RS22540 histidinal L-alanine biosynthesis I aspartate kinase: argininosuccinate lyase: metallophosphatase/ 2,6-diamino-4- α α β HMPREF2590_RS09175 HMPREF2590_RS22050 HMPREF2590_RS22050 HMPREF2590_RS15240 HMPREF2590_RS01035 pro O-acetyl-L-serine 5-phosphate GMP an apurinic site -D-glucopyranose -D-glucopyranose a plant soluble N,N-dimethyl-1,4- two adjacent 2'- -D-glucose yl)-4-hydroxy- a chitosan HMPREF2590_RS09410 HMPREF2590_RS20330 ornithine--oxo-acid HMPREF2590_RS20330 hydrogen sulfide 5'-nucleotidase: hydroxy-5-(N-methyl) an α-limit dextrin anthranilate hydroquinone N 1 - an N- heteroglycan phenylenediamine deoxycytidines in DNA 6-phosphate 2-nonenal 1 histidinol dehydrogenase: L-aspartyl- arginase: bifunctional within DNA 1-phosphate 1-phosphate preuroporphyrinogen N -acetylspermine oxaloacetate fragment 3-methyl-2- argininosuccinate lyase: transaminase: superpathway of L-serine argininosuccinate lyase: uracil 2-deoxy-α-D- HMPREF2590_RS06365 formamidopyrimidine acetylspermidine acetylarylamine HMPREF2590_RS16440 oxobutanoate 4-phosphate HMPREF2590_RS11935 HMPREF2590_RS23635 2-deoxyribose-5- metallophosphatase/ branched-chain-amino- HMPREF2590_RS11200 and glycine biosynthesis I HMPREF2590_RS11200 ATP ribose 1-phosphate [+ 2 isozymes] (S)-1-pyrroline- cysteine synthase: APS phosphate aldolase: 5'-nucleotidase: acid transaminase: aspartate-semialdehyde 5-carboxylate L-methionine biosynthesis III 3-phospho- HMPREF2590_RS14185 phosphopentomutase: HMPREF2590_RS09730 HMPREF2590_RS06365 a single a 1-O-(alk-1-enyl)-sn-glycero- a double his dehydrogenase: arg arg xanthosine maltohexaose maltotetraose a carboxylic ester orotidine 5'- HMPREF2590_RS16390 L-ornithine D-glycerate [+ 2 isozymes] HMPREF2590_RS06300 a sphingomyelin sarcosine preuroporphyrinogen a tRNA Asx asp homogentisate pyruvate pyrroline-5- 3-phosphoglycerate adenylyl-sulfate kinase: sulfate adenylyltransferase: [+ 2 isozymes] stranded DNA 3-phosphoethanolamine stranded DNA phosphate branched-chain-amino- HMPREF2590_RS02355 D-glyceraldehyde guanosine exodeoxyribonuclease lysoplasmalogenase: glycogen/starch/alpha- glycogen/starch/alpha- sphingomyelin carboxylesterase: carboxylate reductase: dehydrogenase: L-arginine degradation HMPREF2590_RS16525 HMPREF2590_RS16520 2-deoxy-D-ribose acetaldehyde glycine oxidase ThiO: uroporphyrinogen- aspartate-- homogentisate orotidine-5'-phosphate acid transaminase: aspartate-semialdehyde L-homoserine spermidine N1- 3-phosphate purine-nucleoside VII large subunit: HMPREF2590_RS00670 glucan phosphorylase: glucan phosphorylase: phosphodiesterase: HMPREF2590_RS22125 DNA gyrase subunit A: pyruvate carboxylase: HMPREF2590_RS23495 HMPREF2590_RS18480 I (arginase pathway) 5-phosphate HMPREF2590_RS24985 III synthase: tRNA(Asn) ligase: 1,2-dioxygenase: decarboxylase: HMPREF2590_RS09545 dehydrogenase: homoserine acetyltransferase: cys PAPS APS purine-nucleoside phosphorylase: HMPREF2590_RS06770 sn-glycero-3- HMPREF2590_RS27680 HMPREF2590_RS27680 HMPREF2590_RS25310 [+ 2 isozymes] HMPREF2590_RS03675 HMPREF2590_RS05580 [+ 3 isozymes] 3-phosphooxypyruvate a fatty aldehyde α α HMPREF2590_RS09180 HMPREF2590_RS03290 HMPREF2590_RS12160 HMPREF2590_RS05260 HMPREF2590_RS04850 acetyltransferase: HMPREF2590_RS22050 HMPREF2590_RS16725 a single-stranded a ribonucleoside phosphoethanolamine -D-glucopyranose -D-glucopyranose methylamine glyoxylate an L-aspartyl- val 2-deoxyribose-5- phosphorylase: maltopentaose maltotriose phosphocholine a ceramide a carboxylate an alcohol a negatively 4-maleyl- UMP L-threonine biosynthesis HMPREF2590_RS26990 arg oligodeoxyribonucleotide 5'-monophosphate 1-phosphate 1-phosphate uroporphyrinogen-III [tRNA Asx ] oxaloacetate L-aspartate- pro O-acetyl-L- N 5 -acetyl- 3-phosphoserine phosphate aldolase: HMPREF2590_RS06295 purine-nucleoside supercoiled DNA acetoacetate hydrogen sulfide arginase: semialdehyde homoserine L-ornithine aminotransferase: HMPREF2590_RS09730 acetyl-CoA purine-nucleoside phosphorylase: HMPREF2590_RS18485 HMPREF2590_RS23635 phosphorylase: HMPREF2590_RS06295 L-homoserine homoserine superpathway of L-asparagine biosynthesis O-acetylhomoserine L-ornithine a [glycine-cleavage a dimer of adjacent a debranched L-gulono- UTP 3-phospho- D-glyceraldehyde HMPREF2590_RS16725 indolylmethylisothiocyanate glutathione a maltodextrin ammonium NAD(P) + H O a colanic acid lipid A-core hν citrate NADH chloramphenicol ferroheme o dehydrogenase: aminocarboxypropyltransferase: SAM complex H protein] 2 α-limit dextrin homoserine kinase: acetaldehyde 3-phosphate xanthine a sulfurated [sulfur carrier] thymidines in DNA 1,4-lactone nucleoside triphosphate ala L-serine 6 glycogen/starch/alpha- HMPREF2590_RS10095 HMPREF2590_RS13850 HMPREF2590_RS26675 ornithine--oxo-acid N -octanoyl-L-lysine VOC family protein: nitrite reductase O-antigen ligase domain- deoxyribodipyrimidine citrate lyase subunit beta: NUDIX hydrolase: glycogen/starch/alpha- chloramphenicol SMP-30/gluconolactonase/ O-phospho- asp guanine lipoyl synthase: glucan phosphorylase: heme A synthase: pyrophosphohydrolase: [+ 2 isozymes] transaminase: HMPREF2590_RS17530 (NAD(P)H) small subunit: containing protein: photo-lyase: HMPREF2590_RS21445 HMPREF2590_RS20715 glucan phosphorylase: acetyltransferase: LRE family protein: L-homoserine alanine racemase: L-homocysteine L-ornithine degradation HMPREF2590_RS21540 indol-3-ylmethylisothiocyanate- HMPREF2590_RS27680 HMPREF2590_RS05575 HMPREF2590_RS08095 a [glycine-cleavage HMPREF2590_RS00190 HMPREF2590_RS22845 HMPREF2590_RS02170 reduced β- HMPREF2590_RS27680 HMPREF2590_RS02370 HMPREF2590_RS13780 HMPREF2590_RS11935 an unsulfurated α-D-glucopyranose two adjacent oxaloacetate acetate HMPREF2590_RS12110 L-homoserine I (L-proline biosynthesis) 5'-deoxyadenosine met complex H protein] glutathione E. coli M nicotinamide D- AMP α-D-glucopyranose UMP asparagine synthase asparagine synthase a maltodextrin nitrite LPS chloramphenicol threonine synthase: 5-methyltetrahydropteroyltriglutamate- L-glutamate-5- [sulfur carrier] 6 1-phosphate thymidines in DNA L-gulonate alanine racemase: acetyl-CoA urate N -lipoyl-L-lysine ribonucleotide 1-phosphate ferroheme a HMPREF2590_RS10090 (glutamine-hydrolyzing): (glutamine-hydrolyzing): - homocysteine S-methyltransferase: methionine synthase: 3-acetate HMPREF2590_RS10585 L-alanine biosynthesis III L-ornithine ser semialdehyde HMPREF2590_RS03115 HMPREF2590_RS11950 HMPREF2590_RS05860 HMPREF2590_RS07115 ornithine cyclodeaminase: L-glutamate gamma- xanthine serine thr D-ala [+ 4 isozymes] [+ 3 isozymes] methionine synthase: HMPREF2590_RS29080 a DNA containing a large- semialdehyde purine ribonucleosides degradation 7,8- 4-fumaryl- α uridine cys HMPREF2590_RS07115 hydroxymethyltransferase: a sulfurated maltoheptaose an apurinic/ HMG-CoA a (1->4)- -D-glucan 2-deoxy-D-ribose catechol ornithine cyclodeaminase: dehydrogenase: SAM dethiobiotin dihydromonapterin asp fumarate acetoacetate a protein branched glucan uridine kinase: cysteine desulfurase: HMPREF2590_RS26220 [sulfur carrier] dihydroneopterin aldolase: glycogen/starch/alpha- apyrimidinic site hydroxymethylglutaryl- fumarylacetoacetase: 1,4-alpha-glucan asn asn HMPREF2590_RS15660 HMPREF2590_RS28215 biotin synthase: endonuclease III: L-aspartate oxidase: endopeptidase La: HMPREF2590_RS07745 HMPREF2590_RS07830 met HMPREF2590_RS08000 glucan phosphorylase: CoA lyase: HMPREF2590_RS12165 branching protein GlgB: ribokinase: pullulanase: catechol 2,3-dioxygenase: pro gly adenosine HMPREF2590_RS06435 HMPREF2590_RS17155 HMPREF2590_RS09345 HMPREF2590_RS09145 [+ 2 isozymes] [+ 2 isozymes] glu urate 6-(hydroxymethyl) HMPREF2590_RS27680 HMPREF2590_RS13545 HMPREF2590_RS27700 HMPREF2590_RS25370 HMPREF2590_RS06730 HMPREF2590_RS20245 an unsulfurated glycolaldehyde α a 3'-terminal a 5'-phospho- acetoacetate fumarate ala met 5'-deoxyadenosine biotin -7,8-dihydropterin -D-glucopyranose succinate 2-iminosuccinate a peptide a peptide a (1,6)-α-D-glucosyl- 2-deoxy-D-ribose a long-linear UMP [sulfur carrier] maltohexaose unsaturated sugar [DNA] acetyl-CoA acetoacetate 1-phosphate (1,4)-α-glucan 5-phosphate α-D-glucan HMS

5,10-methylene- 3-methyl-2- a [protein]- an organic L-ribulose 5- xanthosine adenosine inosine guanosine 2,3,6-trichlorohydroquinone glutathione maltopentaose 3-sulfocatechol N-ethylglycine L-arabinitol a chitodextrin xylitol tetrahydromethanopterin oxobutanoate met L-cysteine hydroperoxide a protein phosphate 3-methyl-2-oxobutanoate VOC family protein: glycogen/starch/alpha- peroxiredoxin: catechol 2,3-dioxygenase: glycine oxidase ThiO: NAD(P)-dependent chitinase: NAD(P)-dependent methionine gamma-lyase: bacillolysin: ribulose-5-phosphate hydroxymethyltransferase: glucan phosphorylase: HMPREF2590_RS17530 HMPREF2590_RS11325 HMPREF2590_RS28025 HMPREF2590_RS20245 HMPREF2590_RS24985 alcohol dehydrogenase: HMPREF2590_RS23155 alcohol dehydrogenase: 4-epimerase: 2,6-dichloro-3-(glutathion- HMPREF2590_RS27680 (2Z,4E)-2- HMPREF2590_RS25665 purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside HMPREF2590_RS17115 an intra- HMPREF2590_RS23565 [+ 2 isozymes] HMPREF2590_RS23565 HMPREF2590_RS11445 α-D-glucopyranose 2-oxobutanoate methanethiol an alcohol sulfite hydroxyhexa- ethylamine glyoxylate phosphorylase: phosphorylase: phosphorylase: phosphorylase: THMPT 2-dehydropantoate S-yl)-hydroquinone protein disulfide a peptide a peptide N,N'- D-xylulose 1-phosphate maltotetraose 2,4-dienedioate L-arabinopyranose D-xylopyranose HMPREF2590_RS16725 HMPREF2590_RS06295 HMPREF2590_RS06295 HMPREF2590_RS06295 diacetylchitobiose 5-phosphate purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside phosphorylase: phosphorylase: phosphorylase: phosphorylase: 3-benzyl-3,6 -bis(cysteinylglycine)- a 5S rRNA a [lipoyl-carrier lysine within a (1->4)- a glucosylated HMPREF2590_RS06295 HMPREF2590_RS16725 HMPREF2590_RS16725 HMPREF2590_RS16725 a glycogen a ribonucleic acid (R)-lipoate (R)-lipoate glutathione fenclorim sec chitin 6-(hydroxymethyl)-diketopiperazine precursor protein]-L-lysine gcv protein H a protein a tRNA ser α-D-glucan glycogenin membrane dipeptidase: ribonuclease M5: glycogen/starch/alpha- ribonuclease PH: lipoate--protein ligase A: lipoate--protein ligase A: VOC family protein: 1,4-alpha-glucan 1,4-alpha-glucan chitinase: α-D-ribose- GPR endopeptidase: serine--tRNA ligase: HMPREF2590_RS04720 glucan phosphorylase: HMPREF2590_RS09085 HMPREF2590_RS11695 HMPREF2590_RS17530 branching protein GlgB: branching protein GlgB: HMPREF2590_RS23155 1-phosphate HMPREF2590_RS08175 HMPREF2590_RS11695 HMPREF2590_RS08270 a double-stranded HMPREF2590_RS27680 a [lipoyl-carrier protein]- a [glycine-cleavage 4-(glutathion- HMPREF2590_RS07450 3-benzyl-3,6 -bis(cysteinyl)- 6- a mature 5S-rRNA a nucleoside a ribonucleic acid an L-seryl- HMPREF2590_RS27700 HMPREF2590_RS27700 [+ 2 isozymes] pyrimidine UTP and CTP dephosphorylation I gly α-D-glucopyranose 6 complex H protein] phosphopentomutase: (hydroxymethyl)-diketopiperazine oligonucleotide diphosphate N -lipoyl-L-lysine S-yl)-fenclorim a peptide a peptide sec maltotetraose 6 [tRNA ] a GlgE-glycogen ribonucleosides HMPREF2590_RS06300 1-phosphate N -lipoyl-L-lysine a glycogen a chitodextrin degradation UTP cytidine D-ribose 5- phosphate cytidine deaminase: CTP synthetase: 3-benzyl-3,6-dihydroxy-6- 2-bromo-3-(4- RNase R degradation a single a ribonucleoside O-ureido-L- (2R,3S)-2- 2'-deoxycytidine α-amylose glutathione glutathione glutathione methylmercury asp glutathione RX L-canavanine 5,6-dihydrouracil HMPREF2590_RS07350 HMPREF2590_RS26335 (hydroxymethyl)-diketopiperazine nitrophenyl)propanoate substrate RNA stranded DNA triphosphate homoserine methylisocitrate deoxynucleoside kinase: VOC family protein: VOC family protein: ribonuclease R: VOC family protein: arginase: cytidine deaminase: CTP synthase: UMP DNA primase: VOC family protein: argininosuccinate synthase: methylisocitrate lyase: HMPREF2590_RS08290 1,4-alpha-glucan HMPREF2590_RS17530 HMPREF2590_RS22120 HMPREF2590_RS17530 HMPREF2590_RS23635 pyrimidine reductase: HMPREF2590_RS09745 HMPREF2590_RS02365 HMPREF2590_RS17530 HMPREF2590_RS07315 HMPREF2590_RS17530 HMPREF2590_RS11205 HMPREF2590_RS02715 branching protein GlgB: bifunctional 3-benzyl-3,6 -bis(glutathione)- 6- 2-(glutathion-S-yl)-3-(4- a nucleoside 5'- ssDNA/pppN(pN) methylmercury- a glutathione- deoxynucleoside kinase: HMPREF2590_RS18255 uridine bromide a diribonucleotide HX pyruvate succinate urea L-canaline HMPREF2590_RS27700 S-methyl-5'-thioadenosine metallophosphatase/ (hydroxymethyl)-diketopiperazine nitrophenyl)propanoate monophosphate hybrid S-glutatione canavaninosuccinate S-conjugate HMPREF2590_RS08285 CTP n -1 uracil amylopectin pyrimidine-nucleoside degradation IV 5'-nucleotidase: dCMP phosphorylase: deoA S-methyl-5'- HMPREF2590_RS06365 pyrimidine-nucleoside thioadenosine [+ 2 isozymes] a 1-(1-alkenyl) a 2'- 5,6- 5'-methylthioadenosine/ RNase III mRNA 2,3,5,6- 1-chloro-2,4- (3Z)-hex- (S)-2,3- β phosphorylase: deoA CMP glutathione -sn-glycero-3- glutathione monochlorobimane glutathione glutathione H O acetyl-CoA -D-allopyranose dihydrothymine D-mannitol S-adenosylhomocysteine uridine processing substrate tetrachlorohydroquinone dinitrobenzene deoxyribonucleoside [DNA] 3-en-1-ol 2 dihydrodipicolinate uracil ribonuclease 3: VOC family protein: phosphocholine VOC family protein: VOC family protein: 5'-triphosphate VOC family protein: acetyl-CoA hydrolase: dipicolinate NAD(P)-dependent nucleosidase: bifunctional lysoplasmalogenase: reverse transcriptase: D-ribose pyranase: pyrimidine reductase: HMPREF2590_RS05090 HMPREF2590_RS17530 HMPREF2590_RS17530 HMPREF2590_RS17530 HMPREF2590_RS17530 HMPREF2590_RS09615 alcohol dehydrogenase: HMPREF2590_RS07710 metallophosphatase/ HMPREF2590_RS00670 HMPREF2590_RS03900 synthase subunit B: HMPREF2590_RS18255 RNase III processing 2,3,5-trichloro-6-(glutathion- (glutathion- 2,4-dinitrophenyl- 3-(glutathion-S HMPREF2590_RS25365 HMPREF2590_RS23565 [+ 3 isozymes] 5'-nucleotidase: an mRNA fragment sn-glycero-3- acetate HMPREF2590_RS04855 product mRNA S-yl)-hydroquinone a fatty aldehyde S-yl)-bimane S-glutathione [DNA] -yl)-hexan-1-ol thymine aldehydo- MTR HMPREF2590_RS06365 phosphocholine dipicolinate β-D-allofuranose D-mannose [+ 2 isozymes] cytidine

Carbohydrate Degradation

ribose phosphorylation chitobiose degradation trehalose degradation I (low osmolarity) xylose degradation I β-D-ribopyranose N,N'- α,α-trehalose D-xylopyranose D-ribose pyranase: diacetylchitobiose 6-phosphate HMPREF2590_RS25365 6'-phosphatechitin disaccharide β-D-ribofuranose deacetylase: alpha,alpha- D-xylulose N-monoacetylchitobioseHMPREF2590_RS22535 phosphotrehalase: 6'-phosphate HMPREF2590_RS25510 gluconokinase: HMPREF2590_RS19075 6-phospho-beta- α-D-ribofuranose glucosidase: glucokinase: D-xylulose HMPREF2590_RS22540 HMPREF2590_RS07165 5-phosphate ribokinase: D-glucopyranose D-glucopyranose HMPREF2590_RS25370 N-acetyl-D- 6-phosphate glucosamine D-glucosamine α -D-ribose 6-phosphate 5-phosphate D-mannose degradation

fructose degradation D-mannopyranose 6-phosphate β-D-fructofuranose mannose-6-phosphate 1-phosphate isomerase, class I: 1-phosphofructokinase: HMPREF2590_RS12825 HMPREF2590_RS04430 β-D-fructose 1,6- F6P bisphosphate D-cellobiose an amino an amino an amino an amino a dicarboxylate a dicarboxylate lactose 6'-phosphate 6'- a sugar 6- a sugar 6- a sugar 6- acid acid acid acid D-mannose D-cellobiose 6'-phosphate molybdate a branched- a branched- an L-sorbose 1-phosphate phosphate a purine phosphate phosphate phosphate an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino 6-phosphate phosphonate glutamate D-trehalose a C4- a sugar 6- a sugar 6- chain chain sn-glycerol sn-glycerol D-fructose D-glucose 6- D-glucose 6- an inorganic an inorganic an inorganic D-mannose D-fructose 1-phosphate lactose 6'-phosphate a pyrimidine a pyrimidine a pyrimidine an aliphatic phosphonate a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA nucleoside a siderophore a nucleotide a macrolide a cyclodextrin a carbohydrate daunorubicin (S)-malate a nucleoside a nucleoside a nucleoside acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid ferrichrome ferrichrome D-glucose D-glucose (S)-lactate (S)-lactate bacitracin bacitracin D-gluconate a tricarboxylate acetamide 6-phosphate dicarboxylate phosphate phosphate an aromatic an aromatic amino acid amino acid 3-phosphate 3-phosphate 1-phosphate phosphate phosphate anion anion anion 6-phosphate D-mannose 6-phosphate D-cellobiose 6'-phosphate nucleoside nucleoside nucleoside sulfonate phosphite cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA carboxylate carboxylate uracil predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC predicted ABC PEP-driven PEP-driven ABC PEP-driven PEP-driven PEP-driven PEP-driven RS00965 RS27810 RS25770 RS21645 RS24865 RS22665 RS09735 RS28095 RS17445 RS11230 RS20475 RS16345 RS10190 RS01995 RS21735 RS25170 RS23040 RS01135 RS25690 RS25225 RS15790 RS02970 RS00765 transporter transporter transporter transporter RS19450 RS25455 RS12155 RS22575 RS24565 RS01530 RS06605 RS00945 RS24640 RS07965 RS07955 RS26545 RS23490 RS12320 RS25830 RS25390 RS04425 RS06105 RS28560 RS19175 RS15730 RS25405 RS25615 RS22630 RS12830 RS23195 transporter of RS05295 RS24705 transporter transporter RS25635 RS21935 RS21940 RS10715 RS20920 RS19080 RS14260 RS21030 RS10160 RS19275 RS08940 RS15745 RS20730 RS20740 RS01105 RS23840 RS26870 RS22080 RS07420 RS22760 RS18145 RS05900 RS25820 transporter RS25515 transporter transporter transporter transporter of an of an of an of an phosphonate of lactose/ of D- of molybdate of a sugar of a sugar of a sugar of D-mannose amino acid amino acid amino acid amino acid D-cellobiose cellobiose a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate

a branched- a branched- L-sorbose lactose lactose a pyrimidine a pyrimidine a pyrimidine a cyclodextrin a carbohydrate trehalose daunorubicin a C4- a sugar a sugar a sugar a sugar a sugar an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino D-glucose D-glucose sn-glycerol sn-glycerol D-fructose D-glucose D-glucose an inorganic an inorganic an inorganic D-mannose D-mannose D-cellobiose D-gluconate an aliphatic phosphonate a siderophore a nucleotide a macrolide glutamate molybdate (S)-malate a nucleoside a nucleoside a nucleoside an aromatic an aromatic chain chain ferrichrome ferrichrome (S)-lactate (S)-lactate D-fructose phosphonate uracil D-cellobiose D-cellobiose nucleoside nucleoside nucleoside bacitracin bacitracin a purine a tricarboxylate acetamide dicarboxylate acid acid acid a dicarboxylatean amino acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid a dicarboxylatean amino acid acid 3-phosphate 3-phosphate anion anion anion sulfonate phosphite acid acid carboxylate carboxylate amino acid amino acid D-mannose nucleoside This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.