Supplementary Figure 1

A APC B TP53 50 50 N/S N/S 40 40

30 30

20 20

10 10 Doubling time (h), SRB (h), Doublingtime Doubling time (h), SRB Doubling time n= 830n= n= 16n= 26 0 0 wt mut wt mut

KRAS BRAF C 50 D 50 N/S 40 40 N/S

30 30

20 20

10 10 Doubling time (h), SRB Doubling time (h), SRB (h), time Doubling n= 19n= 29 n= 39n= 7 0 0 wt mut wt mut

SMAD4 E F 60 N/S

40

20

27 12 (h), SRB time Doubling n= 20n= 5 0 wt mut

G TCF7L2 H CTNNB1 60 50 N/S N/S 40 40 30

20 20 10 Doubling time (h),SRB n= 19n= 6 Doubling (h), SRB time n= 19n= 6 0 0 wt mut wt mut

Supplementary Figure 1: growth as a function of the mutational status of the most frequently mutated in colorectal tumors. The average doubling time of cell lines that are either wild type or mutant for APC (A), TP53 (B), KRAS (C), BRAF (D), PIK3CA (E), SMAD4 (F), TCF7L2 (G)andCTNNB1 (H) was calculated to assess the possible effects on tumor growth of the most frequent mutations observed in colorectal tumors. N/S: Student’s T‐test p>0.05. Supplementary Figure 2 A B 20000 GAPDH TYMS 4000

15000 3000

10000 2000

5000 1554696_s_at 1000 Pearson r =0.459 Pearson r =0.457 P value =0.024

AFFX-HUMGAPDH/M33197_5_at 0 P value =0.037

Relative expression (microarray) 0 0 20 40 60 80 100 Relative expression (microarray) expression Relative 0 20 40 60 80 100 Relative expression (qPCR) Relative expression (qPCR) C D PPOX CALCOCO2 80 80

60 60

40 40 238117_at 238560_at 20 20 Pearson r =0.590 Pearson r =0.772 P value =0.004 P value =0.025 0 0 Relative expression (microarray)

0 20 40 60 80 100 (microarray) Relative expression 0 100 200 300 400 500 Relative expression (qPCR) Relative expression (qPCR) E F CBX5 SMAD4 400 300

300 200

200 231862_at

202526_at 100 100 Pearson r =0.873 Pearson r =0.898 P value =0.015 0 P value =0.001 0 Relative expression (microarray)

0 100 200 300 400 500 Relative expression (microarray) 0 100 200 300 Relative expression (qPCR) Relative expression (qPCR)

Supplementary Figure 2: Independent validation of mRNA expression levels. To independently validate the quantification of mRNA expression of the microarray experiments, the expression of GAPDH (A), TYMS (B), PPOX (C), CALCOCO2 (D), CBX5 (E)andSMAD4(F) was assessed by Real‐Time RT‐PCR. The Pearson’s correlation coefficient (r) and p value are shown. Supplementary Figure 3

A 6 Pearson r=0.54 5 p=0.0007

4

3

2

Percent mitotic cells Percent mitotic 1

0 -2.5 -2.0 -1.5 -1.0 -0.5 0.0 Tumor PPOX mRNA levels

B 6 Pearson r=0.34 5 p=0.04

4

3

2

Percent mitotic cells Percent mitotic 1

0 -2.5 -2.0 -1.5 -1.0 -0.5 0.0 Tumor GAPDH mRNA levels

Supplementary Figure 3: Correlation between PPOX or GAPDH expression and rates of proliferation in primary tumors. The correlation between the mRNA levels of PPOX (A)andGAPDH(B) expression in a cohort of 36 primary colorectal tumors (TCGA) and their proliferation rates (percentage of mitotic cells) is shown. The Pearson’s correlation coefficient (r) and p value are shown. Supplementary Figure 4

30 A Pearson r=0.027 p value=0.897 25 M)

μ 20

15

10

GI50 5-FU GI50 ( 5

0 0 20 40 60 80 Doubling time (h) B 20 Pearson r=0.287 M)

μ P value=0.321 15

10

5

GI50 NaGI50 iodoacetate ( 0 0 20 40 60 80 Doubling time (h)

C 2000 Pearson r=-0.178 P value=0.561 M) μ 1500

1000

500 GI50 Acifluorfen ( Acifluorfen GI50 0 0 20 40 60 80 Doubling time (h)

Supplementary Figure 4: Correlation between drug sensitivity and proliferation rates of colon cells. The doubling time of colon cancer cell lines is plotted against the sensitivity (GI50) of these cell lines to the TYMS inhibitor 5‐FU (A), the GAPDH inhibitor Na iodoacetate (B) or the PPOX inhibitor acifluorfen (C). The Pearson’s correlation coefficient (r) and p value are shown. Supplementary Figure 5

ABHCT116 DLD1 HCT116 DLD1

100 100 **

50 50 ** ** Colony formation (%) formation Colony

Colony formation(%) ** 0 0 0 1200 01200 015 015 Acifluorfen (µM) Na iodoacetate (µM)

CD Acifluorfen Na iodoactetate 100 100 0 μM 0 μM 400 μM 10 μM 80 800 μM 80 20 μM 1200μM 30 μM 60 60

40 40

20 20 Percentage Percentage apoptosis 0 0 DLD1 RW2982 HCT116 T84 LIM2405 DLD1 HCT116 SW403

EF

Supplementary Figure 5: Effects of acifluorfen and Na iodoacetate on the clonogenic potential of colon cancer cells and induction of apoptosis. (A‐B) The number of macroscopically visible colonies after treatment of HCT116 and DLD1 cells with acifluorfen (A)andNaiodoacetate(B)wasassessed2‐3 weeks after 9h treatment with the indicated concentrations. Three independent experiments were carried out in triplicate and the average percentage (±SEM) relative to untreated controls is shown. (C‐D) The percentage of apoptotic cells after treatment of different colon cancer cell lines with the indicated concentrations of acifluorfen (C) or Na iodoacetate (D) was assessed by quantification of the number of cells with a sub‐diploid content of DNA as determined by propidium iodide staining and flow cytometry. The average (±SEM) of three independent experiments each in triplicate is shown. (E‐F)The indicated colon cancer cell lines were treated with acifluorfen (E) or Na iodoacetate (F) for 24h, and the presence of cleaved poly ADP ribose (PARP) was assessed by Western blotting. Supplementary Figure 6

A AcifluorfenB Na iodoacetate

C DLD1 D RW2982 GHLIM2405 DLD1 100 100 100 100

75 75 75 75

50 50 50 50

25 25 Percent of cells Percent of cells 25 25 Percent of cells Percentcells of

0 0 0 0 0 400 800 1200 0 400 800 1200 0 102030 0 102030 Acifluorfen (μM) Acifluorfen (μM) Na iodoacetate (μM) Na iodoacetate (μM)

F IJHCT116 E HCT116 T84 100 SW403 100 100 100

75 75 75 75

50 50 50 50

25 25 25 Percent cells of Percent of cells Percent of cells 25 Percent cells of

0 0 G0/G1 0 0 10 20 30 0 0 400 800 1200 0 400 800 1200 S 0102030 Acifluorfen (μM) Acifluorfen (μM) G2/M Na iodoacetate (μM) Na iodoacetate (μM)

Supplementary Figure 6: Effects of acifluorfen or Na iodoacetate treatment on the of colon cancer cells. The effects of acifluorfen (A)andNaiodoacetate(B) on the distribution of cells in the different phases of the cell cycle were assessed by propidium iodide and flow cytometry analysis. The results of a representative experiment are shownin(A‐B). The number of cells in the G0/G1, G2/M and S‐phase of the cell cycle (DNA content 2n, 4n and 2

0 0

-50 -50 DLD1 (GI50=450.9μM) DLD1 (GI50=212.3μM) HCT116 (GI50=996.9μM) -100 HCT116 (GI50=190.1μM) -100 HCC2998 (GI50=890.1μM) HCC2998 (GI50=142.6μM) -150 Growth inhibition (% of (% control) Growth inhibition Growth of inhibition (% control) 1 2 3 4 0 1 2 3 4 Oxadiazon (Log μM) CGP 3466B maleate (Log μM)

HCT116 HCT116 CD1.5 1.5

1.0 1.0

* 0.5 0.5 * Relative expression Relative expression

0.0 0.0 EFRNAi NT PPOX RNAi NT GAPDH

6 HCT116 HCT116 2.0×10 2.5×10 5

5 6 2.0×10 1.5×10 * * 1.5×10 5 1.0×10 6 1.0×10 5 Cell number Cell 5.0×10 5 number Cell 5.0×10 4

0 0 RNAi NT PPOX RNAi NT GAPDH Supplementary Figure 7: Effects of PPOX and GAPDH inhibition on the growth of colon cancer cells.(A‐B) Treatment with the PPOX inhibitor oxadiazon (A) or the GAPDH inhibitor CGP 3466B maleate (B) caused a dose‐ dependent reduction in the growth of colon cancer cells, as determined by sulforhodamine B staining. (C‐D) Transfection of RNAi oligos targeting PPOX (C)orGAPDH(D) resulted in a reduction in the levels of mRNA expression of these genes compared to untreated controls or cells transfected with a non‐target (NT) RNAi (all 10nM) as determined by qPCR. (E‐F) The number of cells 72h after control non‐target (NT), PPOX (E)orGAPDH(F)RNAi transfection was directly counted. The average (±SEM) of three independent experiments each in triplicate is shown. *Student’s T‐test p<0.05. Supplementary Figure 8

HT29 cells RKO cells 2000 2000 PBS PBS Na iodoacetate Na iodoacetate ) ) 3 3 1500 Acifluorfen 1500 Acifluorfen

1000 1000

500 500 Tumor size (mm Tumor size (mm Tumor

0 0

0 10 20 30 40 0 10 20 30 40 Time post cell injection (days) Time post cell injection (days)

T84 cells Isreco1 cells 1500 500 PBS PBS Aciflorfen Acifluorfen * ) )

3 * 3 * 400 * * * * * * * 1000 * * 300 * * * * * * * * * * * * 200 500 * 100 Tumor size (mm Tumor size Tumor (mm

0 0

0 10 20 30 40 0 10 20 30 Time post cell injection (days) Time post cell injection (days)

HCC2998 cells 800 PBS Acifluorfen ) 3 600

400

200 Tumor size (mm

0

0 10 20 30 40 Time post cell injection (days)

Supplementary Figure 8: Effects of GAPDH and PPOX inhibition on tumor growth using a xenograft model. Groups of NOD/SCID immunodeficient mice (n=8 per group) with subcutaneous xenografts of the indicated cell lines were treated (i.p.) three times per week with acifluorfen (168mg/kg), Na iodoacetate (18.4mg/kg) or vehicle PBS, starting when the tumors reached approximately 80mm3. Arrowheads in the X‐axis indicate treatment times. Tumor size was monitored over time for HT29 (A), RKO (B), T84 (C), Isreco1 (D) or HCC2998 (E) cells. Asterisk indicate statistically significant differences (Student’s T‐test, p<0.05) in the mean tumor size in the control (PBS) group and treatment groups. The mean ± SEM is shown. Supplementary Table 1

Supplementary Table 1: cell lines used in this study.

Doubling time Histological grade Doubling time (h) GI50 Acifluorfen GI50 Na- Cell line MSI/MSSa GI50 5-FU (µM) BRAFb KRASb TP53b APCb PIK3CAb SMAD4b TCF7L2b CTNNB1b SRB (h) on xenografts xCELLigence (µM) iodoacetate (µM) HT29-cl16E 43.37 MSS wt mut mut HT29-cl19A 43.47 MSS wt mut mut ALA 51.58 MSS wt mut mut wt Caco2 51.41 MSS 2.00 15.38 3.11 605.10 4.51 wt wt mut mut wt mut wt mut Co115 27.66 MSI wt wt wt wt Colo201 41.33 MSS 2.00 2.06 mut wt mut mut wt wt wt wt Colo205 26.76 MSS 3.00 1.54 mut wt mut mut wt wt wt wt Colo320 24.19 MSS 3.00 31.31 1.47 wt wt wt mut wt wt wt wt DLD1 25.27 MSI 3.00 16.40 1.32 1310.00 10.05 wt mut mut mut mut wt wt wt FET 35.49 MSS wt mut mut GP5D 60.06 MSI wt mut wt mut mut wt mut wt HCC2998 44.40 MSS 2.00 9.69 1.18 320.27 1.47 wt mut mut mut wt HCT116 25.02 MSI 3.00 9.43 0.69 1004.00 3.29 wt mut wt wt mut wt wt mut HCT15 29.57 MSI 3.00 11.68 3.11 501.20 4.99 wt mut mut mut mut HCT8 27.49 MSI 3.00 14.15 2.84 wt mut wt mut mut wt mut mut HDC108 49.72 MSI wt wt HDC111 43.98 MSS wt mut HDC114 50.28 MSS wt mut HDC133 99.15 MSS HDC15 59.26 MSS wt wt HDC54 42.86 MSS wt wt mut mut wt wt wt mut HDC75 42.53 MSS wt mut HDC8 52.40 MSS HDC87 39.02 MSS wt mut wt mut wt wt wt wt HDC9 49.16 MSI wt wt HT29 36.93 MSS 3.00 28.63 4.20 516.53 5.14 mut wt mut mut mut mut wt wt HUTU80 26.90 MSI Isreco1 20.96 MSS 13.20 294.10 7.94 wt mut mut mut wt Isreco2 52.52 MSS wt mut mut mut wt Isreco3 69.38 MSS 77.31 wt mut mut mut wt KM12 34.11 MSI 2.00 23.61 1.30 wt mut mut wt wt LIM1215 29.52 MSI 2.00 22.45 2.97 wt wt wt wt wt LIM2405 30.72 MSI 3.00 16.42 0.90 15.31 mut wt mut wt wt wt wt LoVo 33.16 MSI 3.00 17.94 1.97 wt mut wt mut wt wt mut wt LS1034 40.79 MSS wt wt mut mut wt LS174T 38.01 MSI 3.00 20.99 5.52 341.70 8.19 mut wt wt mut wt mut mut LS513 33.93 MSS wt mut wt wt wt wt wt wt RKO 36.34 MSI 3.00 0.75 614.97 3.45 mut wt wt wt mut RW2982 58.41 MSS 1.00 41.37 1.62 648.00 wt mut wt mut wt mut wt wt SKCO1 46.56 MSS 3.00 41.73 2.74 wt wt wt mut wt wt wt wt SNUC2B 49.51 MSI wt mut mut wt wt wt mut wt SW1116 68.70 MSS 1.00 19.50 17.10 wt mut mut mut wt wt wt wt SW403 38.19 MSS 1.00 0.68 11.86 wt mut mut mut wt wt wt wt SW48 42.33 MSI 3.00 27.88 4.60 wt wt wt mut mut wt mut mut SW480 30.74 MSS 3.00 10.69 wt mut mut mut wt wt wt wt SW620 37.06 MSS 3.00 27.17 23.09 wt mut mut mut wt SW837 40.60 MSS 3.00 54.07 0.80 wt mut mut mut wt wt wt wt SW948 42.45 MSS 1.00 11.40 1.35 568.33 2.57 wt mut mut mut mut mut wt wt T84 33.90 MSS 2.00 2.60 859.00 wt mut wt mut mut mut wt wt TC71 28.52 MSI 3.00 1.27 wt mut mut wt VACO5 28.85 MSI 270.97 1.07 mut wt mut WiDr 45.68 MSS 27.10 mut wt mut wt a Information taken from Mazzolini R et al. (2011) Brush border Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci U S A.109:1530-5. and Arango D et al. (2005) -expression profiling predicts recurrence in Dukes’ C colorectal cancer. Gastroenterology 129:874–84. b Data from Mouradov D et al. (2014) Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 74(12):3238-47

1 of 1 Supplementary Table 2

Supplementary Table 2: 1593 probes (1,290 unique DAVID IDs) with expression levels significantly correlated with the doubling time of a panel of 31 colorectal cancer cell lines. probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 227257_s_at CACUL1 CDK2-associated, domain 1 -0.74 1.9E-06 1.2E-02 230069_at SFXN1 sideroflexin 1 -0.74 2.2E-06 1.2E-02 222983_s_at PAIP2 poly(A) binding interacting protein 2 -0.74 2.3E-06 1.2E-02 201968_s_at PGM1 phosphoglucomutase 1 -0.73 2.9E-06 1.2E-02 223443_s_at AMZ2P1 archaelysin family metallopeptidase 2 pseudogene 1 -0.73 3.2E-06 1.2E-02 201051_at ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.72 4.6E-06 1.2E-02 207124_s_at GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.72 4.7E-06 1.2E-02 219978_s_at NUSAP1 nucleolar and spindle associated protein 1 -0.72 5.1E-06 1.2E-02 1554740_a_at IPP intracisternal A particle-promoted polypeptide -0.72 6.1E-06 1.2E-02 221677_s_at DONSON downstream neighbor of SON -0.71 7.7E-06 1.2E-02 204285_s_at PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.71 7.9E-06 1.2E-02 202213_s_at CUL4B cullin 4B -0.71 8.4E-06 1.2E-02 223984_s_at NUPL1 nucleoporin like 1 -0.71 8.4E-06 1.2E-02 200892_s_at TRA2B transformer 2 beta homolog (Drosophila) -0.71 8.6E-06 1.2E-02 220631_at OSGEPL1 O- -like 1 -0.71 8.9E-06 1.2E-02 1553158_at CEP19 centrosomal protein 19kDa -0.71 9.4E-06 1.2E-02 208042_at AGGF1 angiogenic factor with G patch and FHA domains 1 -0.70 9.9E-06 1.2E-02 201364_s_at OAZ2 ornithine decarboxylase antizyme 2 -0.70 1.1E-05 1.2E-02 200605_s_at PRKAR1A protein , cAMP-dependent, regulatory, type I, alpha -0.70 1.1E-05 1.2E-02 201823_s_at RNF14 ring finger protein 14 -0.70 1.3E-05 1.5E-02 212702_s_at BICD2 bicaudal D homolog 2 (Drosophila) -0.70 1.4E-05 1.5E-02 203265_s_at MAP2K4 mitogen-activated kinase 4 -0.69 1.5E-05 1.5E-02 218167_at AMZ2 archaelysin family metallopeptidase 2 -0.69 1.7E-05 1.6E-02 222679_s_at DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -0.69 1.8E-05 1.6E-02 235202_x_at IKBIP IKBKB interacting protein -0.69 1.8E-05 1.6E-02 1552680_a_at CASC5 cancer susceptibility candidate 5 -0.69 1.9E-05 1.6E-02 203116_s_at FECH ferrochelatase -0.68 2.4E-05 1.9E-02 215780_s_at SET SET nuclear oncogene -0.68 2.4E-05 1.9E-02 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small 223271_s_at CTDSPL2 -0.68 2.6E-05 1.9E-02 like 2 208925_at CLDND1 claudin domain containing 1 -0.68 2.6E-05 1.9E-02 1554696_s_at TYMS thymidylate synthetase -0.68 2.8E-05 2.0E-02 205519_at WDR76 WD repeat domain 76 -0.67 3.2E-05 2.2E-02 203396_at PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -0.67 3.5E-05 2.3E-02 217725_x_at SERBP1 SERPINE1 mRNA binding protein 1 -0.67 3.8E-05 2.4E-02 1555388_s_at SNX25 sorting nexin 25 -0.67 3.9E-05 2.4E-02 225086_at FAM98B family with sequence similarity 98, member B -0.67 4.1E-05 2.4E-02 1554345_a_at GIN1 gypsy retrotransposon 1 -0.67 4.2E-05 2.4E-02 218133_s_at NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -0.67 4.2E-05 2.4E-02 1558093_s_at MATR3 matrin 3 -0.67 4.4E-05 2.4E-02 204564_at PCGF3 polycomb group ring finger 3 -0.67 4.4E-05 2.4E-02 202300_at LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.66 4.8E-05 2.5E-02 1552277_a_at MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.66 4.8E-05 2.5E-02 1568987_at CRHR1-IT1 CRHR1 intronic transcript 1 (non-protein coding) -0.66 5.3E-05 2.6E-02 218646_at C4orf27 4 open reading frame 27 -0.66 5.4E-05 2.6E-02 202462_s_at DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.66 5.5E-05 2.6E-02 224561_s_at MORF4L1 mortality factor 4 like 1 -0.66 5.6E-05 2.6E-02 226528_at MTX3 metaxin 3 -0.66 6.0E-05 2.6E-02 221381_s_at MORF4L1 mortality factor 4 like 1 -0.66 6.2E-05 2.6E-02 201307_at SEPT11 septin 11 -0.66 6.3E-05 2.6E-02 205321_at EIF2S3 eukaryotic initiation factor 2, subunit 3 gamma, 52kDa -0.65 6.4E-05 2.6E-02 218442_at TTC4 tetratricopeptide repeat domain 4 -0.65 6.5E-05 2.6E-02 225460_at SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -0.65 6.7E-05 2.6E-02 217881_s_at CDC27 cell division cycle 27 -0.65 7.3E-05 2.6E-02 1555841_at MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.65 7.3E-05 2.6E-02 230860_at CEP19 centrosomal protein 19kDa -0.65 7.4E-05 2.6E-02 208670_s_at EID1 EP300 interacting inhibitor of differentiation 1 -0.65 7.4E-05 2.6E-02 205048_s_at PSPH phosphoserine phosphatase -0.65 7.4E-05 2.6E-02 224150_s_at CEP70 centrosomal protein 70kDa -0.65 7.5E-05 2.6E-02 225131_at ZRANB1 finger, RAN-binding domain containing 1 -0.65 7.7E-05 2.6E-02 202089_s_at SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.65 7.8E-05 2.6E-02

207040_s_at ST13 suppression of tumorigenicity 13 (colon carcinoma) ( interacting protein) -0.65 7.9E-05 2.6E-02

219124_at TTI2 TELO2 interacting protein 2 -0.65 7.9E-05 2.6E-02 1557985_s_at CEP78 centrosomal protein 78kDa -0.65 8.3E-05 2.7E-02 200853_at H2AFZ H2A family, member Z -0.65 8.4E-05 2.7E-02 200806_s_at HSPD1 heat shock 60kDa protein 1 () -0.65 8.6E-05 2.7E-02 226897_s_at ZC3H7A CCCH-type containing 7A -0.65 8.8E-05 2.7E-02 213911_s_at H2AFZ H2A histone family, member Z -0.64 9.4E-05 2.8E-02 200071_at SMNDC1 survival motor neuron domain containing 1 -0.64 9.5E-05 2.8E-02 218386_x_at USP16 specific peptidase 16 -0.64 9.9E-05 2.8E-02 223584_s_at KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.64 1.0E-04 2.8E-02 224705_s_at TNRC6A trinucleotide repeat containing 6A -0.64 1.0E-04 2.8E-02 214941_s_at PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.64 1.0E-04 2.9E-02 216326_s_at HDAC3 3 -0.64 1.1E-04 2.9E-02 203406_at MFAP1 microfibrillar-associated protein 1 -0.64 1.1E-04 2.9E-02 1569472_s_at TTC3 tetratricopeptide repeat domain 3 -0.64 1.1E-04 2.9E-02 218871_x_at CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.64 1.1E-04 2.9E-02 224311_s_at CAB39 calcium binding protein 39 -0.64 1.2E-04 2.9E-02 217879_at CDC27 cell division cycle 27 -0.64 1.2E-04 2.9E-02 222558_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.64 1.2E-04 2.9E-02 212105_s_at DHX9 DEAH (Asp-Glu-Ala-His) box 9 -0.63 1.3E-04 2.9E-02 210568_s_at RECQL RecQ protein-like (DNA helicase Q1-like) -0.63 1.3E-04 2.9E-02 1558279_a_at KDSR 3-ketodihydrosphingosine reductase -0.63 1.3E-04 2.9E-02 230281_at C16orf46 open reading frame 46 -0.63 1.3E-04 2.9E-02 210092_at MAGOH mago-nashi homolog, proliferation-associated (Drosophila) -0.63 1.3E-04 2.9E-02 224524_s_at ASB3 repeat and SOCS box containing 3 -0.63 1.3E-04 2.9E-02 220183_s_at NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -0.63 1.4E-04 2.9E-02 213687_s_at RPL35A ribosomal protein L35a -0.63 1.4E-04 2.9E-02 216091_s_at BTRC beta-transducin repeat containing E3 ubiquitin protein -0.63 1.4E-04 2.9E-02

1 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value

206613_s_at TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -0.63 1.4E-04 2.9E-02 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); 216503_s_at MLLT10 -0.63 1.4E-04 2.9E-02 translocated to, 10 202753_at PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.63 1.4E-04 2.9E-02 212517_at ATRN attractin -0.63 1.4E-04 2.9E-02 244324_at C18orf54 open reading frame 54 -0.63 1.4E-04 2.9E-02 238010_at C1orf174 open reading frame 174 -0.63 1.4E-04 2.9E-02

225198_at VAPA VAMP (vesicle-associated )-associated protein A, 33kDa -0.63 1.4E-04 2.9E-02

1552684_a_at SENP8 SUMO/sentrin specific peptidase family member 8 -0.63 1.5E-04 2.9E-02 201386_s_at DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.63 1.5E-04 2.9E-02 225643_at MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.63 1.5E-04 2.9E-02 226800_at EFCAB7 EF-hand calcium binding domain 7 -0.63 1.5E-04 2.9E-02 220295_x_at DEPDC1 DEP domain containing 1 -0.63 1.6E-04 2.9E-02 226091_s_at MRFAP1 Morf4 family associated protein 1 -0.63 1.6E-04 2.9E-02 219553_at NME7 NME/NM23 family member 7 -0.63 1.6E-04 2.9E-02 221673_s_at CSNK1G1 , gamma 1 -0.63 1.6E-04 2.9E-02 231920_s_at CSNK1G1 casein kinase 1, gamma 1 -0.63 1.6E-04 2.9E-02 205087_at RWDD3 RWD domain containing 3 -0.63 1.6E-04 2.9E-02 207319_s_at CDK13 cyclin-dependent kinase 13 -0.63 1.7E-04 2.9E-02 222235_s_at CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.63 1.7E-04 2.9E-02 guanine nucleotide binding protein (G protein), alpha inhibiting activity 201179_s_at GNAI3 -0.63 1.7E-04 2.9E-02 polypeptide 3 207707_s_at SEC13 SEC13 homolog (S. cerevisiae) -0.63 1.7E-04 2.9E-02 205425_at HIP1 huntingtin interacting protein 1 -0.62 1.7E-04 2.9E-02 219148_at PBK PDZ binding kinase -0.62 1.7E-04 2.9E-02 227077_at ZNF286A zinc finger protein 286A -0.62 1.8E-04 2.9E-02 202641_at ARL3 ADP-ribosylation factor-like 3 -0.62 1.8E-04 2.9E-02 202107_s_at MCM2 minichromosome maintenance complex component 2 -0.62 1.9E-04 3.0E-02 1568680_s_at YTHDC2 YTH domain containing 2 -0.62 1.9E-04 3.0E-02 1554423_a_at FBXO7 F-box protein 7 -0.62 1.9E-04 3.0E-02 208656_s_at CCNI cyclin I -0.62 2.0E-04 3.1E-02 202479_s_at TRIB2 tribbles homolog 2 (Drosophila) -0.62 2.0E-04 3.1E-02 227413_at UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -0.62 2.0E-04 3.1E-02 238844_s_at NPHP1 nephronophthisis 1 (juvenile) -0.62 2.1E-04 3.2E-02 211968_s_at HSP90AA1 90kDa alpha (cytosolic), class A member 1 -0.62 2.1E-04 3.2E-02 226748_at LYSMD2 LysM, putative -binding, domain containing 2 -0.62 2.1E-04 3.2E-02 212720_at PAPOLA poly(A) polymerase alpha -0.62 2.1E-04 3.2E-02 212918_at RECQL RecQ protein-like (DNA helicase Q1-like) -0.62 2.2E-04 3.2E-02 240983_s_at CARS cysteinyl-tRNA synthetase -0.62 2.2E-04 3.2E-02 203053_at BCAS2 breast carcinoma amplified sequence 2 -0.62 2.2E-04 3.2E-02 203198_at CDK9 cyclin-dependent kinase 9 -0.62 2.2E-04 3.2E-02 201594_s_at PPP4R1 4, regulatory subunit 1 -0.62 2.2E-04 3.2E-02 204603_at EXO1 1 -0.62 2.2E-04 3.2E-02 200886_s_at PGAM1 phosphoglycerate mutase 1 (brain) -0.62 2.3E-04 3.2E-02 203015_s_at SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.62 2.3E-04 3.3E-02 219409_at SNIP1 Smad nuclear interacting protein 1 -0.61 2.3E-04 3.3E-02 210502_s_at PPIE peptidylprolyl E (cyclophilin E) -0.61 2.4E-04 3.3E-02 213998_s_at DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.61 2.4E-04 3.3E-02 224280_s_at MTFR1L mitochondrial fission regulator 1-like -0.61 2.4E-04 3.3E-02 241836_x_at CEP97 centrosomal protein 97kDa -0.61 2.4E-04 3.3E-02 227713_at KATNAL1 katanin p60 subunit A-like 1 -0.61 2.4E-04 3.3E-02 201231_s_at ENO1 enolase 1, (alpha) -0.61 2.5E-04 3.3E-02 1560599_a_at CEP89 centrosomal protein 89kDa -0.61 2.5E-04 3.3E-02 218340_s_at UBA6 ubiquitin-like modifier activating 6 -0.61 2.5E-04 3.3E-02 229603_at BBS12 Bardet-Biedl syndrome 12 -0.61 2.6E-04 3.3E-02 235006_at CDKN2AIPNL CDKN2A interacting protein N-terminal like -0.61 2.6E-04 3.3E-02 201133_s_at PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.61 2.6E-04 3.3E-02 201274_at PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -0.61 2.6E-04 3.3E-02 222634_s_at TBL1XR1 transducin (beta)-like 1 X-linked 1 -0.61 2.6E-04 3.3E-02 203138_at HAT1 histone acetyltransferase 1 -0.61 2.7E-04 3.3E-02 202589_at TYMS thymidylate synthetase -0.61 2.7E-04 3.3E-02 231857_s_at AGBL5 ATP/GTP binding protein-like 5 -0.61 2.7E-04 3.4E-02 223135_s_at BBX bobby sox homolog (Drosophila) -0.61 2.7E-04 3.4E-02 1557910_at HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.61 2.7E-04 3.4E-02 1554868_s_at PCNP PEST proteolytic signal containing nuclear protein -0.61 2.8E-04 3.4E-02 1556551_s_at SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.61 2.8E-04 3.4E-02 205356_at USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.61 2.8E-04 3.4E-02 203210_s_at RFC5 (activator 1) 5, 36.5kDa -0.61 2.9E-04 3.4E-02 218348_s_at ZC3H7A zinc finger CCCH-type containing 7A -0.61 2.9E-04 3.5E-02 220941_s_at C21orf91 chromosome 21 open reading frame 91 -0.61 3.0E-04 3.5E-02 213329_at SRGAP2 SLIT-ROBO Rho GTPase -0.61 3.0E-04 3.5E-02 214462_at SOCS6 suppressor of cytokine signaling 6 -0.61 3.0E-04 3.5E-02 222729_at FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.61 3.1E-04 3.5E-02 225689_at POMGNT2 glycosyltransferase-like domain containing 2 -0.61 3.1E-04 3.5E-02 219467_at GIN1 gypsy retrotransposon integrase 1 -0.60 3.1E-04 3.5E-02 1555814_a_at RHOA ras homolog family member A -0.60 3.1E-04 3.5E-02 210257_x_at CUL4B cullin 4B -0.60 3.2E-04 3.6E-02 235216_at ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.60 3.2E-04 3.6E-02 209345_s_at PI4K2A phosphatidylinositol 4-kinase type 2 alpha -0.60 3.3E-04 3.6E-02 209085_x_at RFC1 replication factor C (activator 1) 1, 145kDa -0.60 3.3E-04 3.6E-02 218830_at RPL26L1 ribosomal protein L26-like 1 -0.60 3.3E-04 3.6E-02 225476_at GPANK1 G patch domain and ankyrin repeats 1 -0.60 3.3E-04 3.6E-02 218349_s_at ZWILCH zwilch kinetochore protein -0.60 3.3E-04 3.6E-02 212534_at ZNF24 zinc finger protein 24 -0.60 3.4E-04 3.6E-02 204315_s_at GTSE1 G-2 and S-phase expressed 1 -0.60 3.4E-04 3.7E-02 205335_s_at SRP19 signal recognition particle 19kDa -0.60 3.5E-04 3.7E-02 217960_s_at TOMM22 of outer mitochondrial membrane 22 homolog () -0.60 3.5E-04 3.7E-02 228822_s_at USP16 ubiquitin specific peptidase 16 -0.60 3.5E-04 3.7E-02 219688_at BBS7 Bardet-Biedl syndrome 7 -0.60 3.5E-04 3.7E-02 202143_s_at COPS8 COP9 signalosome subunit 8 -0.60 3.6E-04 3.7E-02

2 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding 209330_s_at HNRNPD -0.60 3.6E-04 3.7E-02 protein 1, 37kDa) 222610_s_at S100PBP S100P binding protein -0.60 3.6E-04 3.7E-02 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. 208310_s_at CCZ1 -0.60 3.6E-04 3.7E-02 cerevisiae) 217923_at PEF1 penta-EF-hand domain containing 1 -0.60 3.6E-04 3.7E-02 235059_at RAB12 RAB12, member RAS oncogene family -0.60 3.6E-04 3.7E-02 204809_at CLPX ClpX caseinolytic peptidase X homolog (E. coli) -0.60 3.7E-04 3.7E-02 227092_at CTD-2336O2.1 NULL -0.60 3.7E-04 3.7E-02 238117_at PPOX protoporphyrinogen oxidase -0.60 3.8E-04 3.7E-02 204427_s_at TMED2 transmembrane emp24 domain trafficking protein 2 -0.60 3.8E-04 3.7E-02 239090_at FAM161A family with sequence similarity 161, member A -0.60 3.8E-04 3.7E-02 206052_s_at SLBP stem-loop binding protein -0.60 3.8E-04 3.7E-02 228986_at OSBPL8 oxysterol binding protein-like 8 -0.60 3.9E-04 3.8E-02 224719_s_at C12orf57 open reading frame 57 -0.60 3.9E-04 3.8E-02 221497_x_at EGLN1 egl nine homolog 1 (C. elegans) -0.60 3.9E-04 3.8E-02 232287_at ERCC6-PGBD3 ERCC6-PGBD3 readthrough -0.60 3.9E-04 3.8E-02 200613_at AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.60 3.9E-04 3.8E-02 201151_s_at MBNL1 muscleblind-like splicing regulator 1 -0.60 3.9E-04 3.8E-02 232095_at ------0.60 4.0E-04 3.8E-02 220892_s_at PSAT1 phosphoserine aminotransferase 1 -0.60 4.0E-04 3.8E-02 207785_s_at RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.60 4.0E-04 3.8E-02 222559_s_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.60 4.1E-04 3.9E-02 201635_s_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.59 4.2E-04 3.9E-02 221220_s_at SCYL2 SCY1-like 2 (S. cerevisiae) -0.59 4.3E-04 4.0E-02 202798_at SEC24B SEC24 family, member B (S. cerevisiae) -0.59 4.3E-04 4.0E-02 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated 213209_at TAF6L -0.59 4.4E-04 4.0E-02 factor, 65kDa 201457_x_at BUB3 BUB3 mitotic checkpoint protein -0.59 4.4E-04 4.0E-02 201222_s_at RAD23B RAD23 homolog B (S. cerevisiae) -0.59 4.4E-04 4.0E-02 212986_s_at TLK2 tousled-like kinase 2 -0.59 4.4E-04 4.0E-02 219240_s_at C10orf88 open reading frame 88 -0.59 4.5E-04 4.0E-02 211016_x_at HSPA4 heat shock 70kDa protein 4 -0.59 4.5E-04 4.0E-02 212002_at SZRD1 SUZ RNA binding domain containing 1 -0.59 4.5E-04 4.0E-02 212421_at KIAA0930 KIAA0930 -0.59 4.6E-04 4.0E-02 210018_x_at MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 -0.59 4.6E-04 4.0E-02 201485_s_at RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.59 4.6E-04 4.0E-02 201161_s_at YBX3 Y box binding protein 3 -0.59 4.6E-04 4.0E-02 225192_at CACUL1 CDK2-associated, cullin domain 1 -0.59 4.7E-04 4.0E-02 219730_at LOC100996782 of RNA polymerase II transcription subunit 18-like -0.59 4.7E-04 4.0E-02 235331_x_at PCGF5 polycomb group ring finger 5 -0.59 4.7E-04 4.0E-02 1553956_at TMEM237 transmembrane protein 237 -0.59 4.7E-04 4.0E-02 206066_s_at RAD51C RAD51 homolog C (S. cerevisiae) -0.59 4.7E-04 4.0E-02 217538_at SGSM2 small G protein signaling modulator 2 -0.59 4.7E-04 4.0E-02 222975_s_at CSDE1 cold shock domain containing E1, RNA-binding -0.59 4.8E-04 4.0E-02 215997_s_at CUL4B cullin 4B -0.59 4.8E-04 4.0E-02 212967_x_at NAP1L1 assembly protein 1-like 1 -0.59 4.8E-04 4.0E-02 202899_s_at SRSF3 /-rich splicing factor 3 -0.59 4.8E-04 4.0E-02 232008_s_at BBX bobby sox homolog (Drosophila) -0.59 4.9E-04 4.0E-02 224314_s_at EGLN1 egl nine homolog 1 (C. elegans) -0.59 4.9E-04 4.0E-02 1555844_s_at HNRNPM heterogeneous nuclear ribonucleoprotein M -0.59 4.9E-04 4.0E-02 211077_s_at TLK1 tousled-like kinase 1 -0.59 4.9E-04 4.0E-02 213470_s_at HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.59 5.0E-04 4.1E-02 223474_at IRF2BPL regulatory factor 2 binding protein-like -0.59 5.0E-04 4.1E-02 200097_s_at HNRNPK heterogeneous nuclear ribonucleoprotein K -0.59 5.0E-04 4.1E-02 213922_at TTBK2 tau kinase 2 -0.59 5.0E-04 4.1E-02 217993_s_at MAT2B adenosyltransferase II, beta -0.59 5.1E-04 4.1E-02 209662_at CETN3 centrin, EF-hand protein, 3 -0.59 5.2E-04 4.1E-02 222626_at RBM26 RNA binding motif protein 26 -0.59 5.2E-04 4.1E-02 235007_at BBS7 Bardet-Biedl syndrome 7 -0.59 5.3E-04 4.2E-02 232033_at USP37 ubiquitin specific peptidase 37 -0.59 5.3E-04 4.2E-02 226258_at AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) -0.59 5.4E-04 4.2E-02 1557217_a_at FANCB Fanconi anemia, complementation group B -0.59 5.5E-04 4.2E-02 226851_at LYPLAL1 -like 1 -0.59 5.5E-04 4.2E-02 218404_at SNX10 sorting nexin 10 -0.58 5.5E-04 4.2E-02 204426_at TMED2 transmembrane emp24 domain trafficking protein 2 -0.58 5.5E-04 4.2E-02 201308_s_at SEPT11 septin 11 -0.58 5.6E-04 4.3E-02 201946_s_at CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.58 5.6E-04 4.3E-02 231852_at ERI1 1 -0.58 5.6E-04 4.3E-02 200937_s_at RPL5 ribosomal protein L5 -0.58 5.6E-04 4.3E-02 217301_x_at RBBP4 retinoblastoma binding protein 4 -0.58 5.6E-04 4.3E-02 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole 201014_s_at PAICS -0.58 5.7E-04 4.3E-02 succinocarboxamide synthetase 222826_at BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin -0.58 5.8E-04 4.3E-02 210240_s_at CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -0.58 5.8E-04 4.3E-02 205091_x_at RECQL RecQ protein-like (DNA helicase Q1-like) -0.58 5.8E-04 4.3E-02 1554176_a_at C3orf33 open reading frame 33 -0.58 5.9E-04 4.3E-02 208825_x_at RPL23A ribosomal protein L23a -0.58 5.9E-04 4.3E-02 209257_s_at SMC3 structural maintenance of 3 -0.58 5.9E-04 4.3E-02 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 201020_at YWHAH -0.58 5.9E-04 4.3E-02 polypeptide 223084_s_at CCNDBP1 cyclin D-type binding-protein 1 -0.58 6.0E-04 4.3E-02 1554513_s_at CEP89 centrosomal protein 89kDa -0.58 6.0E-04 4.3E-02 218370_s_at S100PBP S100P binding protein -0.58 6.0E-04 4.3E-02 202203_s_at AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -0.58 6.1E-04 4.3E-02 212075_s_at CSNK2A1 , alpha 1 polypeptide -0.58 6.1E-04 4.3E-02 218047_at OSBPL9 oxysterol binding protein-like 9 -0.58 6.1E-04 4.3E-02 201619_at PRDX3 peroxiredoxin 3 -0.58 6.1E-04 4.3E-02 201696_at SRSF4 serine/arginine-rich splicing factor 4 -0.58 6.1E-04 4.3E-02 235653_s_at THAP6 THAP domain containing 6 -0.58 6.2E-04 4.3E-02 211804_s_at CDK2 cyclin-dependent kinase 2 -0.58 6.2E-04 4.4E-02 1552344_s_at CNOT7 CCR4-NOT transcription complex, subunit 7 -0.58 6.2E-04 4.4E-02 200033_at DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.58 6.3E-04 4.4E-02

3 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 201577_at NME1 NME/NM23 nucleoside diphosphate kinase 1 -0.58 6.4E-04 4.4E-02 206038_s_at NR2C2 subfamily 2, group C, member 2 -0.58 6.4E-04 4.4E-02 210935_s_at WDR1 WD repeat domain 1 -0.58 6.4E-04 4.4E-02 222703_s_at YRDC yrdC domain containing (E. coli) -0.58 6.4E-04 4.4E-02 224641_at FYTTD1 forty-two-three domain containing 1 -0.58 6.5E-04 4.4E-02 225194_at PLRG1 pleiotropic regulator 1 -0.58 6.6E-04 4.4E-02 214553_s_at ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.58 6.6E-04 4.4E-02 225244_at LOC100130093 uncharacterized LOC100130093 -0.58 6.6E-04 4.4E-02 212055_at TPGS2 tubulin polyglutamylase complex subunit 2 -0.58 6.6E-04 4.4E-02 205053_at PRIM1 , DNA, polypeptide 1 (49kDa) -0.58 6.7E-04 4.5E-02 1560916_a_at DPY19L1 dpy-19-like 1 (C. elegans) -0.58 6.8E-04 4.5E-02 226152_at TTC7B tetratricopeptide repeat domain 7B -0.58 6.9E-04 4.6E-02 217294_s_at ENO1 enolase 1, (alpha) -0.58 7.0E-04 4.6E-02 211080_s_at NEK2 NIMA-related kinase 2 -0.58 7.1E-04 4.6E-02 1555789_s_at PHF23 PHD finger protein 23 -0.58 7.1E-04 4.6E-02 211762_s_at KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.57 7.2E-04 4.6E-02 202836_s_at TXNL4A thioredoxin-like 4A -0.57 7.2E-04 4.6E-02 202874_s_at ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -0.57 7.2E-04 4.6E-02 218462_at RPF1 ribosome production factor 1 homolog (S. cerevisiae) -0.57 7.2E-04 4.6E-02 202413_s_at USP1 ubiquitin specific peptidase 1 -0.57 7.2E-04 4.6E-02 59999_at HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -0.57 7.4E-04 4.6E-02

209139_s_at PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -0.57 7.4E-04 4.6E-02

209344_at TPM4 4 -0.57 7.4E-04 4.6E-02 223701_s_at USP47 ubiquitin specific peptidase 47 -0.57 7.4E-04 4.6E-02 214659_x_at YLPM1 YLP motif containing 1 -0.57 7.4E-04 4.6E-02 202861_at PER1 period circadian 1 -0.57 7.5E-04 4.7E-02 222600_s_at UBA6 ubiquitin-like modifier activating enzyme 6 -0.57 7.5E-04 4.7E-02 208756_at EIF3I eukaryotic translation initiation factor 3, subunit I -0.57 7.5E-04 4.7E-02 210114_at INVS inversin -0.57 7.5E-04 4.7E-02 222984_at PAIP2 poly(A) binding protein interacting protein 2 -0.57 7.6E-04 4.7E-02 208644_at PARP1 poly (ADP-ribose) polymerase 1 -0.57 7.6E-04 4.7E-02 228745_at SGTB small -rich tetratricopeptide repeat (TPR)-containing, beta -0.57 7.6E-04 4.7E-02 201742_x_at SRSF1 serine/arginine-rich splicing factor 1 -0.57 7.6E-04 4.7E-02 204827_s_at CCNF cyclin F -0.57 7.7E-04 4.7E-02 1564637_a_at FAM98B family with sequence similarity 98, member B -0.57 7.7E-04 4.7E-02 222726_s_at EXOC5 exocyst complex component 5 -0.57 7.8E-04 4.7E-02 204145_at FRG1 FSHD region gene 1 -0.57 7.8E-04 4.7E-02 201266_at TXNRD1 thioredoxin reductase 1 -0.57 7.8E-04 4.7E-02 213875_x_at C6orf62 open reading frame 62 -0.57 7.9E-04 4.7E-02 201599_at OAT ornithine aminotransferase -0.57 7.9E-04 4.7E-02 232860_x_at RBM41 RNA binding motif protein 41 -0.57 7.9E-04 4.7E-02 202301_s_at RSRC2 arginine/serine-rich coiled-coil 2 -0.57 7.9E-04 4.7E-02 225229_at AFF4 AF4/FMR2 family, member 4 -0.57 8.0E-04 4.7E-02 224642_at FYTTD1 forty-two-three domain containing 1 -0.57 8.0E-04 4.7E-02 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 211754_s_at SLC25A17 -0.57 8.0E-04 4.7E-02 34kDa), member 17 219258_at TIPIN TIMELESS interacting protein -0.57 8.1E-04 4.8E-02 204544_at HPS5 Hermansky-Pudlak syndrome 5 -0.57 8.2E-04 4.8E-02 203018_s_at SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.57 8.3E-04 4.8E-02 201091_s_at CBX3 chromobox homolog 3 -0.57 8.4E-04 4.8E-02 211801_x_at MFN1 mitofusin 1 -0.57 8.4E-04 4.8E-02 216988_s_at PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.57 8.4E-04 4.8E-02 221705_s_at SIKE1 suppressor of IKBKE 1 -0.57 8.4E-04 4.8E-02 210334_x_at BIRC5 baculoviral IAP repeat containing 5 -0.57 8.5E-04 4.9E-02 218398_at MRPS30 mitochondrial ribosomal protein S30 -0.57 8.5E-04 4.9E-02 225565_at CREB1 cAMP responsive element binding protein 1 -0.57 8.6E-04 4.9E-02 209849_s_at RAD51C RAD51 homolog C (S. cerevisiae) -0.57 8.6E-04 5.0E-02 221620_s_at APOO apolipoprotein O -0.57 8.7E-04 5.0E-02 208669_s_at EID1 EP300 interacting inhibitor of differentiation 1 -0.57 8.7E-04 5.0E-02 204732_s_at TRIM23 tripartite motif containing 23 -0.57 8.8E-04 5.0E-02 212065_s_at USP34 ubiquitin specific peptidase 34 -0.57 8.8E-04 5.0E-02 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small 223270_at CTDSPL2 -0.57 8.9E-04 5.0E-02 phosphatase like 2 225384_at dedicator of cytokinesis 7 -0.57 8.9E-04 5.0E-02 204000_at GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.57 8.9E-04 5.0E-02 209259_s_at SMC3 structural maintenance of chromosomes 3 -0.57 8.9E-04 5.0E-02 207630_s_at CREM cAMP responsive element modulator -0.57 9.1E-04 5.0E-02 229106_at DYNLL2 , light chain, LC8-type 2 -0.57 9.1E-04 5.0E-02 1553726_s_at TBC1D32 chromosome 6 open reading frame 170 -0.57 9.1E-04 5.0E-02 202009_at TWF2 twinfilin -binding protein 2 -0.57 9.1E-04 5.0E-02 229850_at KDSR 3-ketodihydrosphingosine reductase -0.57 9.2E-04 5.0E-02 227083_at B3GALTL beta 1,3-galactosyltransferase-like -0.56 9.3E-04 5.0E-02 215509_s_at BUB1 BUB1 mitotic checkpoint serine/ kinase -0.56 9.3E-04 5.0E-02 239596_at SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.56 9.3E-04 5.0E-02 225092_at RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.56 9.4E-04 5.1E-02 209162_s_at PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast) -0.56 9.4E-04 5.1E-02 208309_s_at MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 -0.56 9.5E-04 5.1E-02 1553122_s_at RBAK RB-associated KRAB zinc finger -0.56 9.5E-04 5.1E-02 228135_at C1orf52 chromosome 1 open reading frame 52 -0.56 9.6E-04 5.1E-02 210658_s_at GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -0.56 9.6E-04 5.1E-02 228773_at LOC100506100 uncharacterized LOC100506100 -0.56 9.6E-04 5.1E-02 226046_at MAPK8 mitogen-activated protein kinase 8 -0.56 9.7E-04 5.1E-02 215134_at PI4K2A phosphatidylinositol 4-kinase type 2 alpha -0.56 9.7E-04 5.1E-02 201529_s_at RPA1 , 70kDa -0.56 9.8E-04 5.1E-02 205836_s_at YTHDC2 YTH domain containing 2 -0.56 9.8E-04 5.1E-02 201043_s_at ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.56 9.9E-04 5.1E-02 223857_x_at EMC4 ER membrane protein complex subunit 4 -0.56 9.9E-04 5.1E-02 201365_at OAZ2 ornithine decarboxylase antizyme 2 -0.56 9.9E-04 5.1E-02 208680_at PRDX1 peroxiredoxin 1 -0.56 9.9E-04 5.1E-02 201486_at RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.56 1.0E-03 5.2E-02 200624_s_at MATR3 matrin 3 -0.56 1.0E-03 5.2E-02 201614_s_at RUVBL1 RuvB-like 1 (E. coli) -0.56 1.0E-03 5.2E-02

4 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 219637_at ARMC9 armadillo repeat containing 9 -0.56 1.0E-03 5.2E-02 218013_x_at DCTN4 dynactin 4 (p62) -0.56 1.0E-03 5.2E-02 218854_at DSE dermatan sulfate epimerase -0.56 1.0E-03 5.2E-02 232023_at TMEM67 transmembrane protein 67 -0.56 1.0E-03 5.2E-02 223228_at LDOC1L , down-regulated in cancer 1-like -0.56 1.0E-03 5.2E-02 218622_at NUP37 nucleoporin 37kDa -0.56 1.0E-03 5.2E-02 204361_s_at SKAP2 src kinase associated phosphoprotein 2 -0.56 1.0E-03 5.2E-02 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 210317_s_at YWHAE -0.56 1.0E-03 5.2E-02 epsilon polypeptide 213906_at MYBL1 v- myeloblastosis viral oncogene homolog (avian)-like 1 -0.56 1.0E-03 5.2E-02 219502_at NEIL3 nei VIII-like 3 (E. coli) -0.56 1.1E-03 5.2E-02 234987_at SAMHD1 SAM domain and HD domain 1 -0.56 1.1E-03 5.2E-02 212617_at ZNF609 zinc finger protein 609 -0.56 1.1E-03 5.2E-02 224919_at MRPS6 mitochondrial ribosomal protein S6 -0.56 1.1E-03 5.2E-02 1563111_a_at PIGX phosphatidylinositol glycan anchor , class X -0.56 1.1E-03 5.2E-02 217915_s_at RSL24D1 ribosomal L24 domain containing 1 -0.56 1.1E-03 5.2E-02 238794_at SFR1 SWI5-dependent recombination repair 1 -0.56 1.1E-03 5.2E-02 1554397_s_at UEVLD UEV and lactate/malate dehyrogenase domains -0.56 1.1E-03 5.3E-02 210821_x_at CENPA centromere protein A -0.56 1.1E-03 5.3E-02 229181_s_at HAUS2 HAUS augmin-like complex, subunit 2 -0.56 1.1E-03 5.3E-02 228859_at C4orf21 open reading frame 21 -0.56 1.1E-03 5.3E-02 219939_s_at CSDE1 cold shock domain containing E1, RNA-binding -0.56 1.1E-03 5.3E-02 232278_s_at DEPDC1 DEP domain containing 1 -0.56 1.1E-03 5.3E-02 211022_s_at ATRX alpha thalassemia/mental retardation syndrome X-linked -0.56 1.1E-03 5.4E-02 229442_at C18orf54 chromosome 18 open reading frame 54 -0.56 1.1E-03 5.4E-02 201573_s_at ETF1 eukaryotic translation termination factor 1 -0.56 1.1E-03 5.4E-02 209421_at MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) -0.56 1.1E-03 5.4E-02 217100_s_at UBXN7 UBX domain protein 7 -0.56 1.1E-03 5.4E-02 212367_at FEM1B fem-1 homolog b (C. elegans) -0.56 1.2E-03 5.4E-02 206920_s_at GLE1 GLE1 RNA export mediator homolog (yeast) -0.56 1.2E-03 5.4E-02 211681_s_at PDLIM5 PDZ and LIM domain 5 -0.56 1.2E-03 5.4E-02 209455_at FBXW11 F-box and WD repeat domain containing 11 -0.56 1.2E-03 5.5E-02 219094_at ARMC8 armadillo repeat containing 8 -0.56 1.2E-03 5.5E-02 222617_s_at FAM204A family with sequence similarity 204, member A -0.56 1.2E-03 5.5E-02 212277_at MTMR4 related protein 4 -0.56 1.2E-03 5.5E-02 203209_at RFC5 replication factor C (activator 1) 5, 36.5kDa -0.56 1.2E-03 5.5E-02 203087_s_at KIF2A heavy chain member 2A -0.55 1.2E-03 5.6E-02 202113_s_at SNX2 sorting nexin 2 -0.55 1.2E-03 5.6E-02 223369_at NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -0.55 1.2E-03 5.6E-02 201831_s_at USO1 USO1 vesicle transport factor -0.55 1.2E-03 5.6E-02 220285_at ABHD17B abhydrolase domain containing 17B -0.55 1.2E-03 5.6E-02 204905_s_at EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -0.55 1.2E-03 5.7E-02 205996_s_at AK2 2 -0.55 1.2E-03 5.7E-02 201299_s_at MOB1A MOB kinase activator 1A -0.55 1.2E-03 5.7E-02 209174_s_at QRICH1 glutamine-rich 1 -0.55 1.2E-03 5.7E-02 224025_s_at ATG7 autophagy related 7 -0.55 1.3E-03 5.7E-02 212835_at FAM175B family with sequence similarity 175, member B -0.55 1.3E-03 5.7E-02 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide 210005_at GART -0.55 1.3E-03 5.7E-02 synthetase, phosphoribosylaminoimidazole synthetase

202354_s_at GTF2F1 general IIF, polypeptide 1, 74kDa -0.55 1.3E-03 5.7E-02 227840_at C2orf76 open reading frame 76 -0.55 1.3E-03 5.7E-02 242760_x_at PIGB phosphatidylinositol glycan anchor biosynthesis, class B -0.55 1.3E-03 5.7E-02 235354_s_at RSRC1 arginine/serine-rich coiled-coil 1 -0.55 1.3E-03 5.7E-02 AFFX- HUMGAPDH/M GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.55 1.3E-03 5.7E-02 33197_5_at 236249_at IKBIP IKBKB interacting protein -0.55 1.3E-03 5.7E-02 200858_s_at RPS8 ribosomal protein S8 -0.55 1.3E-03 5.8E-02 218185_s_at ARMC1 armadillo repeat containing 1 -0.55 1.3E-03 5.8E-02 203941_at INTS9 integrator complex subunit 9 -0.55 1.3E-03 5.8E-02 200749_at RAN RAN, member RAS oncogene family -0.55 1.3E-03 5.8E-02 202468_s_at CTNNAL1 (cadherin-associated protein), alpha-like 1 -0.55 1.3E-03 5.8E-02 222993_at MRPL37 mitochondrial ribosomal protein L37 -0.55 1.3E-03 5.8E-02

211547_s_at PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.55 1.3E-03 5.8E-02

209511_at POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.55 1.3E-03 5.8E-02 225263_at HS6ST1 6-O-sulfotransferase 1 -0.55 1.3E-03 5.8E-02 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex- 202491_s_at IKBKAP -0.55 1.3E-03 5.8E-02 associated protein 202817_s_at SS18 synovial sarcoma translocation, chromosome 18 -0.55 1.3E-03 5.8E-02 204833_at ATG12 autophagy related 12 -0.55 1.4E-03 5.8E-02 221703_at BRIP1 BRCA1 interacting -terminal helicase 1 -0.55 1.4E-03 5.8E-02 224937_at PTGFRN prostaglandin F2 receptor inhibitor -0.55 1.4E-03 5.8E-02 208021_s_at RFC1 replication factor C (activator 1) 1, 145kDa -0.55 1.4E-03 5.8E-02 222682_s_at FAM114A2 family with sequence similarity 114, member A2 -0.55 1.4E-03 5.8E-02 230329_s_at NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -0.55 1.4E-03 5.8E-02 204317_at TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase -0.55 1.4E-03 5.8E-02

207507_s_at ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) -0.55 1.4E-03 5.9E-02

212373_at FEM1B fem-1 homolog b (C. elegans) -0.55 1.4E-03 5.9E-02 228680_at KIF3A kinesin family member 3A -0.55 1.4E-03 5.9E-02 207079_s_at MED6 mediator complex subunit 6 -0.55 1.4E-03 5.9E-02 219211_at USP18 ubiquitin specific peptidase 18 -0.55 1.4E-03 5.9E-02 202705_at CCNB2 cyclin B2 -0.55 1.4E-03 5.9E-02 218582_at MARCH5 membrane-associated ring finger (C3HC4) 5 -0.55 1.4E-03 5.9E-02 223114_at COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -0.55 1.4E-03 5.9E-02 203925_at GCLM glutamate-cysteine ligase, modifier subunit -0.55 1.4E-03 5.9E-02 224582_s_at NUCKS1 nuclear casein kinase and cyclin-dependent kinase 1 -0.55 1.4E-03 5.9E-02 235260_s_at PACRGL PARK2 co-regulated-like -0.55 1.4E-03 5.9E-02 220200_s_at SETD8 SET domain containing ( methyltransferase) 8 -0.55 1.4E-03 5.9E-02 223378_at GLIS2 GLIS family zinc finger 2 -0.55 1.5E-03 6.0E-02 201225_s_at SRRM1 serine/arginine repetitive matrix 1 -0.55 1.5E-03 6.0E-02

5 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 220770_s_at C5orf54 open reading frame 54 -0.55 1.5E-03 6.0E-02 227514_at ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.55 1.5E-03 6.0E-02 221691_x_at NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.55 1.5E-03 6.0E-02 229038_at CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -0.55 1.5E-03 6.0E-02 221591_s_at FAM64A family with sequence similarity 64, member A -0.55 1.5E-03 6.0E-02 1555978_s_at MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.55 1.5E-03 6.0E-02 219767_s_at CRYZL1 , zeta (quinone reductase)-like 1 -0.55 1.5E-03 6.0E-02 203012_x_at RPL23A ribosomal protein L23a -0.55 1.5E-03 6.0E-02 222708_s_at STX17 syntaxin 17 -0.55 1.5E-03 6.0E-02 223428_s_at ISY1 ISY1 splicing factor homolog (S. cerevisiae) -0.55 1.5E-03 6.0E-02 212348_s_at KDM1A lysine (K)-specific demethylase 1A -0.55 1.5E-03 6.0E-02 223542_at ANKRD32 ankyrin repeat domain 32 -0.54 1.5E-03 6.0E-02 211090_s_at PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast) -0.54 1.5E-03 6.0E-02 224854_s_at SLAIN2 SLAIN motif family, member 2 -0.54 1.5E-03 6.0E-02 212698_s_at SEPT10 septin 10 -0.54 1.6E-03 6.1E-02

217883_at MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -0.54 1.6E-03 6.1E-02

208833_s_at ATXN10 ataxin 10 -0.54 1.6E-03 6.1E-02 214869_x_at GAPVD1 GTPase activating protein and VPS9 domains 1 -0.54 1.6E-03 6.1E-02 231840_x_at LYRM7 LYR motif containing 7 -0.54 1.6E-03 6.1E-02 224853_at SLAIN2 SLAIN motif family, member 2 -0.54 1.6E-03 6.1E-02 233750_s_at TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -0.54 1.6E-03 6.1E-02 242753_x_at AP1AR adaptor-related protein complex 1 associated regulatory protein -0.54 1.6E-03 6.1E-02 219927_at FCF1 FCF1 rRNA-processing protein -0.54 1.6E-03 6.1E-02 202579_x_at HMGN4 high mobility group nucleosomal binding domain 4 -0.54 1.6E-03 6.1E-02 200650_s_at LDHA lactate dehydrogenase A -0.54 1.6E-03 6.1E-02 1554249_a_at ZNF638 zinc finger protein 638 -0.54 1.6E-03 6.1E-02 208752_x_at NAP1L1 nucleosome assembly protein 1-like 1 -0.54 1.6E-03 6.1E-02 215707_s_at PRNP prion protein -0.54 1.6E-03 6.1E-02 209895_at PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.54 1.6E-03 6.1E-02 209024_s_at SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.54 1.6E-03 6.1E-02 223078_s_at TMOD3 3 (ubiquitous) -0.54 1.6E-03 6.1E-02 228998_at TNRC6B trinucleotide repeat containing 6B -0.54 1.6E-03 6.1E-02 201337_s_at VAMP3 vesicle-associated membrane protein 3 -0.54 1.6E-03 6.1E-02 223043_at EMC4 ER membrane protein complex subunit 4 -0.54 1.6E-03 6.1E-02 203348_s_at ETV5 -0.54 1.6E-03 6.1E-02 204195_s_at PKNOX1 PBX/knotted 1 1 -0.54 1.6E-03 6.1E-02 215357_s_at POLDIP3 polymerase (DNA-directed), delta interacting protein 3 -0.54 1.6E-03 6.1E-02 37577_at ARHGAP19 Rho GTPase activating protein 19 -0.54 1.6E-03 6.1E-02 208931_s_at ILF3 interleukin enhancer binding factor 3, 90kDa -0.54 1.6E-03 6.1E-02 218217_at SCPEP1 serine 1 -0.54 1.6E-03 6.1E-02 201784_s_at C11orf58 open reading frame 58 -0.54 1.7E-03 6.1E-02 228946_at INTU inturned planar cell polarity protein -0.54 1.7E-03 6.1E-02 235435_at AASDH aminoadipate-semialdehyde dehydrogenase -0.54 1.7E-03 6.1E-02 204286_s_at PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.54 1.7E-03 6.1E-02 235722_at SYNJ2BP 2 binding protein -0.54 1.7E-03 6.1E-02 1557684_at ZNF286A zinc finger protein 286A -0.54 1.7E-03 6.1E-02

212577_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.54 1.7E-03 6.2E-02

201971_s_at ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -0.54 1.7E-03 6.2E-02 222000_at C1orf174 chromosome 1 open reading frame 174 -0.54 1.7E-03 6.2E-02 211730_s_at POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.54 1.7E-03 6.2E-02

201881_s_at ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) -0.54 1.7E-03 6.2E-02

214663_at DSTYK dual serine/threonine and tyrosine protein kinase -0.54 1.7E-03 6.2E-02 1554518_at GSTCD glutathione S-, C-terminal domain containing -0.54 1.7E-03 6.2E-02 238959_at LARP4 La ribonucleoprotein domain family, member 4 -0.54 1.7E-03 6.2E-02 1554577_a_at PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -0.54 1.7E-03 6.2E-02 1861_at BAD BCL2-associated agonist of cell death -0.54 1.7E-03 6.2E-02 228019_s_at MRPS18C mitochondrial ribosomal protein S18C -0.54 1.7E-03 6.2E-02 203511_s_at TRAPPC3 trafficking protein particle complex 3 -0.54 1.7E-03 6.2E-02 204492_at ARHGAP11A Rho GTPase activating protein 11A -0.54 1.8E-03 6.2E-02 212746_s_at CEP170 centrosomal protein 170kDa -0.54 1.8E-03 6.2E-02 1554761_a_at HEATR2 HEAT repeat containing 2 -0.54 1.8E-03 6.2E-02 228736_at HELQ helicase, POLQ-like -0.54 1.8E-03 6.2E-02 202069_s_at IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -0.54 1.8E-03 6.2E-02 200712_s_at MAPRE1 -associated protein, RP/EB family, member 1 -0.54 1.8E-03 6.2E-02 230146_s_at NCS1 neuronal calcium sensor 1 -0.54 1.8E-03 6.2E-02 215747_s_at RCC1 regulator of chromosome condensation 1 -0.54 1.8E-03 6.2E-02 1554321_a_at NFS1 NFS1 fixation 1 homolog (S. cerevisiae) -0.54 1.8E-03 6.3E-02 209018_s_at PINK1 PTEN induced putative kinase 1 -0.54 1.8E-03 6.3E-02 225950_at SAMD8 sterile alpha motif domain containing 8 -0.54 1.8E-03 6.3E-02 200669_s_at UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.54 1.8E-03 6.3E-02 201514_s_at G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.54 1.8E-03 6.3E-02 224898_at WDR26 WD repeat domain 26 -0.54 1.8E-03 6.3E-02 200598_s_at HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.54 1.8E-03 6.3E-02 1553106_at C5orf24 chromosome 5 open reading frame 24 -0.54 1.8E-03 6.3E-02

222874_s_at CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -0.54 1.8E-03 6.3E-02

218147_s_at GLT8D1 glycosyltransferase 8 domain containing 1 -0.54 1.8E-03 6.3E-02 202787_s_at MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -0.54 1.9E-03 6.4E-02 217466_x_at RPS2 ribosomal protein S2 -0.54 1.9E-03 6.4E-02 200750_s_at RAN RAN, member RAS oncogene family -0.54 1.9E-03 6.4E-02 231055_at ------0.54 1.9E-03 6.4E-02 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), 202825_at SLC25A4 -0.54 1.9E-03 6.4E-02 member 4 242594_at BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.54 1.9E-03 6.4E-02 201637_s_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.54 1.9E-03 6.4E-02 202736_s_at LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.54 1.9E-03 6.4E-02 SWI/SNF-related, matrix-associated actin-dependent regulator of , 223197_s_at SMARCAD1 -0.54 1.9E-03 6.4E-02 subfamily a, containing DEAD/H box 1 208699_x_at TKT transketolase -0.54 1.9E-03 6.4E-02 216074_x_at WWC1 WW and C2 domain containing 1 -0.54 1.9E-03 6.4E-02

6 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 209967_s_at CREM cAMP responsive element modulator -0.54 1.9E-03 6.4E-02 213490_s_at MAP2K2 mitogen-activated protein kinase kinase 2 -0.54 1.9E-03 6.4E-02 211009_s_at ZNF271 zinc finger protein 271 -0.54 1.9E-03 6.4E-02 212893_at ZZZ3 zinc finger, ZZ-type containing 3 -0.54 1.9E-03 6.4E-02 212561_at DENND5A DENN/MADD domain containing 5A -0.53 1.9E-03 6.4E-02 guanine nucleotide binding protein (G protein), alpha inhibiting activity 201180_s_at GNAI3 -0.53 1.9E-03 6.4E-02 polypeptide 3 218461_at GPN3 GPN-loop GTPase 3 -0.53 1.9E-03 6.4E-02 218713_at NARG2 NMDA receptor regulated 2 -0.53 1.9E-03 6.4E-02 244563_at QSER1 glutamine and serine rich 1 -0.53 1.9E-03 6.4E-02 225614_at SAAL1 -like 1 -0.53 1.9E-03 6.4E-02 218737_at SBNO1 strawberry notch homolog 1 (Drosophila) -0.53 1.9E-03 6.4E-02 211085_s_at STK4 serine/threonine kinase 4 -0.53 1.9E-03 6.4E-02 1552334_at TRIOBP TRIO and F-actin binding protein -0.53 1.9E-03 6.4E-02 213289_at APOOL apolipoprotein O-like -0.53 2.0E-03 6.4E-02 213262_at SACS spastic ataxia of Charlevoix-Saguenay (sacsin) -0.53 2.0E-03 6.4E-02

1558747_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.53 2.0E-03 6.4E-02

203667_at TBCA tubulin folding A -0.53 2.0E-03 6.4E-02 229888_at C12orf60 chromosome 12 open reading frame 60 -0.53 2.0E-03 6.4E-02 235296_at EIF5A2 eukaryotic translation initiation factor 5A2 -0.53 2.0E-03 6.4E-02 225304_s_at FUT5 5 (alpha (1,3) fucosyltransferase) -0.53 2.0E-03 6.4E-02 208911_s_at PDHB pyruvate dehydrogenase (lipoamide) beta -0.53 2.0E-03 6.4E-02 222404_x_at PTPLAD1 protein tyrosine phosphatase-like A domain containing 1 -0.53 2.0E-03 6.4E-02 222439_s_at THRAP3 thyroid associated protein 3 -0.53 2.0E-03 6.4E-02 203247_s_at ZNF24 zinc finger protein 24 -0.53 2.0E-03 6.4E-02 217010_s_at CDC25C cell division cycle 25C -0.53 2.0E-03 6.4E-02 206562_s_at CSNK1A1 casein kinase 1, alpha 1 -0.53 2.0E-03 6.4E-02 209078_s_at TXN2 thioredoxin 2 -0.53 2.0E-03 6.4E-02 221598_s_at MED27 mediator complex subunit 27 -0.53 2.0E-03 6.4E-02 235793_at TPGS2 tubulin polyglutamylase complex subunit 2 -0.53 2.0E-03 6.4E-02 218042_at COPS4 COP9 signalosome subunit 4 -0.53 2.0E-03 6.5E-02 AFFX- HUMGAPDH/M GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.53 2.0E-03 6.5E-02 33197_M_at 201490_s_at PPIF peptidylprolyl isomerase F -0.53 2.0E-03 6.5E-02 1552660_a_at C5orf22 chromosome 5 open reading frame 22 -0.53 2.1E-03 6.5E-02 229863_s_at ELP6 elongator acetyltransferase complex subunit 6 -0.53 2.1E-03 6.5E-02 226020_s_at DAB1 Dab, signal transducer, homolog 1 (Drosophila) -0.53 2.1E-03 6.5E-02 224563_at WASF2 WAS , member 2 -0.53 2.1E-03 6.5E-02 200974_at ACTA2 actin, alpha 2, smooth muscle, aorta -0.53 2.1E-03 6.5E-02 236957_at CDCA2 cell division cycle associated 2 -0.53 2.1E-03 6.5E-02 200044_at GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -0.53 2.1E-03 6.5E-02 202432_at PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.53 2.1E-03 6.5E-02 224883_at BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin -0.53 2.1E-03 6.5E-02 1553120_at CLSPN claspin -0.53 2.1E-03 6.5E-02 1562921_at ------0.53 2.1E-03 6.5E-02 223700_at MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) -0.53 2.1E-03 6.5E-02 227408_s_at SNX25 sorting nexin 25 -0.53 2.1E-03 6.5E-02 235440_at SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.53 2.1E-03 6.5E-02 224334_s_at MRPL51 mitochondrial ribosomal protein L51 -0.53 2.1E-03 6.5E-02 230676_s_at TMEM19 transmembrane protein 19 -0.53 2.1E-03 6.5E-02 222430_s_at YTHDF2 YTH domain family, member 2 -0.53 2.1E-03 6.5E-02 206098_at ZBTB6 zinc finger and BTB domain containing 6 -0.53 2.1E-03 6.5E-02 231188_at ZSCAN2 zinc finger and SCAN domain containing 2 -0.53 2.1E-03 6.5E-02 203214_x_at CDK1 cyclin-dependent kinase 1 -0.53 2.1E-03 6.5E-02 212079_s_at KMT2A lysine (K)-specific methyltransferase 2A -0.53 2.1E-03 6.5E-02 238963_at RBM18 RNA binding motif protein 18 -0.53 2.1E-03 6.5E-02 219171_s_at ZNF236 zinc finger protein 236 -0.53 2.1E-03 6.5E-02 200038_s_at RPL17 ribosomal protein L17 -0.53 2.2E-03 6.5E-02 207405_s_at RAD17 RAD17 homolog (S. pombe) -0.53 2.2E-03 6.5E-02 218441_s_at RPAP1 RNA polymerase II associated protein 1 -0.53 2.2E-03 6.5E-02 232038_at TBC1D32 chromosome 6 open reading frame 170 -0.53 2.2E-03 6.5E-02 201636_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.53 2.2E-03 6.6E-02 224326_s_at PCGF6 polycomb group ring finger 6 -0.53 2.2E-03 6.6E-02 228185_at ZNF25 zinc finger protein 25 -0.53 2.2E-03 6.6E-02 1554424_at FIP1L1 FIP1 like 1 (S. cerevisiae) -0.53 2.2E-03 6.6E-02 1557915_s_at GSTO1 glutathione S-transferase omega 1 -0.53 2.2E-03 6.6E-02 218977_s_at TRNAU1AP tRNA selenocysteine 1 associated protein 1 -0.53 2.2E-03 6.6E-02 210775_x_at CASP9 caspase 9, apoptosis-related cysteine peptidase -0.53 2.2E-03 6.6E-02 222574_s_at DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -0.53 2.2E-03 6.6E-02 222632_s_at LZTFL1 leucine zipper transcription factor-like 1 -0.53 2.2E-03 6.6E-02 228578_at RBM45 RNA binding motif protein 45 -0.53 2.2E-03 6.6E-02 229399_at C10orf118 chromosome 10 open reading frame 118 -0.53 2.3E-03 6.7E-02 235195_at FBXW2 F-box and WD repeat domain containing 2 -0.53 2.3E-03 6.7E-02 200059_s_at RHOA ras homolog family member A -0.53 2.3E-03 6.7E-02 205329_s_at SNX4 sorting nexin 4 -0.53 2.3E-03 6.7E-02 219844_at C10orf118 chromosome 10 open reading frame 118 -0.53 2.3E-03 6.7E-02 226548_at SBK1 SH3-binding domain kinase 1 -0.53 2.3E-03 6.7E-02 238511_at UBL7-AS1 UBL7 antisense RNA 1 (head to head) -0.53 2.3E-03 6.7E-02 228201_at ARL13B ADP-ribosylation factor-like 13B -0.53 2.3E-03 6.7E-02 218648_at CRTC3 CREB regulated transcription 3 -0.53 2.3E-03 6.7E-02 213872_at ------0.53 2.3E-03 6.7E-02 pleckstrin domain containing, family A (phosphoinositide binding 227658_s_at PLEKHA3 -0.53 2.3E-03 6.7E-02 specific) member 3 200732_s_at PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.53 2.3E-03 6.7E-02 225302_at TMX3 thioredoxin-related transmembrane protein 3 -0.53 2.3E-03 6.7E-02 225976_at BTF3L4 basic transcription factor 3-like 4 -0.53 2.3E-03 6.7E-02 201988_s_at CREBL2 cAMP responsive element binding protein-like 2 -0.53 2.3E-03 6.7E-02 200072_s_at HNRNPM heterogeneous nuclear ribonucleoprotein M -0.53 2.3E-03 6.7E-02 226007_at ISCA2 -sulfur cluster assembly 2 homolog (S. cerevisiae) -0.53 2.3E-03 6.7E-02 201476_s_at RRM1 M1 -0.53 2.3E-03 6.7E-02 210188_at GABPA GA binding protein transcription factor, alpha subunit 60kDa -0.53 2.3E-03 6.7E-02

7 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 239973_at ------0.53 2.3E-03 6.7E-02 223368_s_at NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -0.53 2.3E-03 6.7E-02 226642_s_at NUDCD2 NudC domain containing 2 -0.53 2.3E-03 6.7E-02 225958_at PHC1 polyhomeotic homolog 1 (Drosophila) -0.53 2.3E-03 6.7E-02 244287_at SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.53 2.3E-03 6.7E-02 201483_s_at SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -0.53 2.3E-03 6.7E-02 208624_s_at EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.53 2.4E-03 6.7E-02 226810_at OGFRL1 opioid growth factor receptor-like 1 -0.53 2.4E-03 6.7E-02 209052_s_at WHSC1 -Hirschhorn syndrome candidate 1 -0.53 2.4E-03 6.7E-02 219917_at ZCCHC4 zinc finger, CCHC domain containing 4 -0.53 2.4E-03 6.7E-02 213453_x_at GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.53 2.4E-03 6.7E-02 208066_s_at GTF2B general transcription factor IIB -0.53 2.4E-03 6.7E-02 217982_s_at MORF4L1 mortality factor 4 like 1 -0.53 2.4E-03 6.7E-02 200718_s_at SKP1 S-phase kinase-associated protein 1 -0.53 2.4E-03 6.7E-02 224619_at CASC4 cancer susceptibility candidate 4 -0.53 2.4E-03 6.8E-02 205811_at POLG2 polymerase (DNA directed), gamma 2, accessory subunit -0.53 2.4E-03 6.8E-02 59437_at C9orf116 open reading frame 116 -0.52 2.4E-03 6.8E-02 excision repair cross-complementing rodent repair deficiency, complementation 1554883_a_at ERCC8 -0.52 2.4E-03 6.8E-02 group 8 223248_at HSDL1 hydroxysteroid dehydrogenase like 1 -0.52 2.4E-03 6.8E-02

212301_at RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.52 2.4E-03 6.8E-02

238154_at CEP70 centrosomal protein 70kDa -0.52 2.4E-03 6.8E-02 214507_s_at EXOSC2 exosome component 2 -0.52 2.4E-03 6.8E-02 222867_s_at MED31 mediator complex subunit 31 -0.52 2.4E-03 6.8E-02 201821_s_at TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -0.52 2.4E-03 6.8E-02 209157_at DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -0.52 2.5E-03 6.8E-02 217872_at PIH1D1 PIH1 domain containing 1 -0.52 2.5E-03 6.8E-02 207805_s_at PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -0.52 2.5E-03 6.8E-02 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 221618_s_at TAF9B -0.52 2.5E-03 6.8E-02 31kDa 233186_s_at BANP BTG3 associated nuclear protein -0.52 2.5E-03 6.8E-02 203266_s_at MAP2K4 mitogen-activated protein kinase kinase 4 -0.52 2.5E-03 6.8E-02 205085_at ORC1 origin recognition complex, subunit 1 -0.52 2.5E-03 6.8E-02 227246_at PLRG1 pleiotropic regulator 1 -0.52 2.5E-03 6.8E-02 202583_s_at RANBP9 RAN binding protein 9 -0.52 2.5E-03 6.8E-02 227726_at RNF166 ring finger protein 166 -0.52 2.5E-03 6.8E-02 202657_s_at SERTAD2 SERTA domain containing 2 -0.52 2.5E-03 6.8E-02 200850_s_at AHCYL1 adenosylhomocysteinase-like 1 -0.52 2.5E-03 6.9E-02 213864_s_at NAP1L1 nucleosome assembly protein 1-like 1 -0.52 2.5E-03 6.9E-02 229838_at NUCB2 nucleobindin 2 -0.52 2.5E-03 6.9E-02 225386_s_at HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -0.52 2.5E-03 6.9E-02 227508_at ------0.52 2.5E-03 6.9E-02 222474_s_at TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -0.52 2.5E-03 6.9E-02 218534_s_at AGGF1 angiogenic factor with G patch and FHA domains 1 -0.52 2.6E-03 6.9E-02 218097_s_at CUEDC2 CUE domain containing 2 -0.52 2.6E-03 6.9E-02 211375_s_at ILF3 interleukin enhancer binding factor 3, 90kDa -0.52 2.6E-03 6.9E-02 242486_at ------0.52 2.6E-03 6.9E-02 223004_s_at TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 -0.52 2.6E-03 6.9E-02 205071_x_at XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.52 2.6E-03 6.9E-02 205369_x_at DBT dihydrolipoamide branched chain transacylase E2 -0.52 2.6E-03 6.9E-02 237065_s_at LAMTOR5-AS1 LAMTOR5 antisense RNA 1 -0.52 2.6E-03 6.9E-02 218738_s_at RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.52 2.6E-03 6.9E-02 214359_s_at HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.52 2.6E-03 6.9E-02 227295_at IKBIP IKBKB interacting protein -0.52 2.6E-03 6.9E-02 223831_x_at ISY1 ISY1 splicing factor homolog (S. cerevisiae) -0.52 2.6E-03 6.9E-02 217043_s_at MFN1 mitofusin 1 -0.52 2.6E-03 6.9E-02 207845_s_at ANAPC10 anaphase promoting complex subunit 10 -0.52 2.6E-03 6.9E-02 211755_s_at ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -0.52 2.6E-03 6.9E-02 209055_s_at CDC5L cell division cycle 5-like -0.52 2.6E-03 6.9E-02 202142_at COPS8 COP9 signalosome subunit 8 -0.52 2.6E-03 6.9E-02 guanine nucleotide binding protein (G protein), alpha inhibiting activity 201040_at GNAI2 -0.52 2.6E-03 6.9E-02 polypeptide 2 226370_at KLHL15 kelch-like family member 15 -0.52 2.6E-03 6.9E-02 223081_at PHF23 PHD finger protein 23 -0.52 2.6E-03 6.9E-02 200604_s_at PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.52 2.6E-03 6.9E-02 1557227_s_at TPR translocated promoter region, nuclear basket protein -0.52 2.6E-03 6.9E-02 218132_s_at TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae) -0.52 2.6E-03 6.9E-02 225904_at CCSAP , cilia and spindle-associated protein -0.52 2.7E-03 6.9E-02 206383_s_at G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.52 2.7E-03 6.9E-02 214220_s_at ALMS1 Alstrom syndrome 1 -0.52 2.7E-03 7.0E-02 223738_s_at PGM2 phosphoglucomutase 2 -0.52 2.7E-03 7.0E-02 201030_x_at LDHB lactate dehydrogenase B -0.52 2.7E-03 7.0E-02 200013_at RPL24 ribosomal protein L24 -0.52 2.7E-03 7.0E-02 203340_s_at SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -0.52 2.7E-03 7.0E-02 210813_s_at XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.52 2.7E-03 7.0E-02 222440_s_at THRAP3 associated protein 3 -0.52 2.7E-03 7.0E-02 201554_x_at GYG1 glycogenin 1 -0.52 2.8E-03 7.0E-02 1553810_a_at KIAA1524 KIAA1524 -0.52 2.8E-03 7.0E-02 1555514_a_at PIAS2 protein inhibitor of activated STAT, 2 -0.52 2.8E-03 7.0E-02 225953_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.52 2.8E-03 7.0E-02 225057_at SLC15A4 solute carrier family 15, member 4 -0.52 2.8E-03 7.0E-02 233070_at ZNF197 zinc finger protein 197 -0.52 2.8E-03 7.0E-02 213599_at OIP5 Opa interacting protein 5 -0.52 2.8E-03 7.1E-02 214167_s_at RPLP0 ribosomal protein, large, P0 -0.52 2.8E-03 7.1E-02 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 1558136_s_at TAF11 -0.52 2.8E-03 7.1E-02 28kDa 235918_x_at CEP97 centrosomal protein 97kDa -0.52 2.8E-03 7.1E-02 200943_at HMGN1 high mobility group nucleosome binding domain 1 -0.52 2.8E-03 7.1E-02 235545_at DEPDC1 DEP domain containing 1 -0.52 2.8E-03 7.1E-02 209187_at DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -0.52 2.8E-03 7.1E-02 218294_s_at NUP50 nucleoporin 50kDa -0.52 2.8E-03 7.1E-02

8 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 205966_at TAF13 -0.52 2.8E-03 7.1E-02 18kDa 231809_x_at PDCD7 programmed cell death 7 -0.52 2.9E-03 7.1E-02 209896_s_at PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.52 2.9E-03 7.1E-02 212997_s_at TLK2 tousled-like kinase 2 -0.52 2.9E-03 7.1E-02 213617_s_at TPGS2 tubulin polyglutamylase complex subunit 2 -0.52 2.9E-03 7.1E-02 242584_at FAM161A family with sequence similarity 161, member A -0.52 2.9E-03 7.2E-02 209669_s_at SERBP1 SERPINE1 mRNA binding protein 1 -0.52 2.9E-03 7.2E-02 204270_at SKI v-ski sarcoma viral oncogene homolog (avian) -0.52 2.9E-03 7.2E-02 207974_s_at SKP1 S-phase kinase-associated protein 1 -0.52 2.9E-03 7.2E-02 212712_at CAMSAP1 calmodulin regulated -associated protein 1 -0.52 2.9E-03 7.2E-02

1553694_a_at PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.52 2.9E-03 7.2E-02

209180_at RABGGTB Rab geranylgeranyltransferase, beta subunit -0.52 2.9E-03 7.2E-02 1552470_a_at ABHD11 abhydrolase domain containing 11 -0.52 2.9E-03 7.2E-02 217880_at CDC27 cell division cycle 27 -0.52 2.9E-03 7.2E-02 203032_s_at FH fumarate hydratase -0.52 2.9E-03 7.2E-02 37512_at HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -0.52 2.9E-03 7.2E-02 211713_x_at KIAA0101 KIAA0101 -0.52 2.9E-03 7.2E-02 210251_s_at RUFY3 RUN and FYVE domain containing 3 -0.52 2.9E-03 7.2E-02 1568733_at C10orf76 chromosome 10 open reading frame 76 -0.52 3.0E-03 7.2E-02 202225_at CRK v-crk sarcoma virus CT10 oncogene homolog (avian) -0.52 3.0E-03 7.2E-02 223486_at GTPBP8 GTP-binding protein 8 (putative) -0.52 3.0E-03 7.2E-02 225742_at MDM4 Mdm4 binding protein homolog (mouse) -0.52 3.0E-03 7.2E-02 1560222_at ------0.52 3.0E-03 7.2E-02 201160_s_at YBX3 Y box binding protein 3 -0.52 3.0E-03 7.2E-02 203022_at RNASEH2A H2, subunit A -0.52 3.0E-03 7.2E-02 216899_s_at SKAP2 src kinase associated phosphoprotein 2 -0.52 3.0E-03 7.2E-02 226565_at TMEM99 transmembrane protein 99 -0.52 3.0E-03 7.2E-02 222816_s_at ZCCHC2 zinc finger, CCHC domain containing 2 -0.52 3.0E-03 7.2E-02 201698_s_at GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -0.52 3.0E-03 7.3E-02 227825_at NAIF1 nuclear apoptosis inducing factor 1 -0.52 3.0E-03 7.3E-02 234000_s_at PTPLAD1 protein tyrosine phosphatase-like A domain containing 1 -0.52 3.0E-03 7.3E-02 211972_x_at RPLP0 ribosomal protein, large, P0 -0.52 3.0E-03 7.3E-02 217970_s_at CNOT6 CCR4-NOT transcription complex, subunit 6 -0.51 3.0E-03 7.3E-02 201574_at ETF1 eukaryotic translation termination factor 1 -0.51 3.0E-03 7.3E-02 220500_s_at RABL2A RAB, member of RAS oncogene family-like 2A -0.51 3.0E-03 7.3E-02 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 216226_at TAF4B -0.51 3.0E-03 7.3E-02 105kDa 219649_at ALG6 ALG6, alpha-1,3-glucosyltransferase -0.51 3.1E-03 7.3E-02 225766_s_at TNPO1 transportin 1 -0.51 3.1E-03 7.3E-02 203197_s_at C1orf123 chromosome 1 open reading frame 123 -0.51 3.1E-03 7.4E-02 33494_at ETFDH electron-transferring-flavoprotein dehydrogenase -0.51 3.1E-03 7.4E-02 211767_at GINS4 GINS complex subunit 4 (Sld5 homolog) -0.51 3.1E-03 7.4E-02 213084_x_at RPL23A ribosomal protein L23a -0.51 3.1E-03 7.4E-02 231713_s_at ELP2 elongator acetyltransferase complex subunit 2 -0.51 3.1E-03 7.4E-02 231869_at KIAA1586 KIAA1586 -0.51 3.1E-03 7.4E-02 204023_at RFC4 replication factor C (activator 1) 4, 37kDa -0.51 3.1E-03 7.4E-02 222431_at SPIN1 spindlin 1 -0.51 3.1E-03 7.4E-02 1554271_a_at CENPL centromere protein L -0.51 3.2E-03 7.5E-02 1554489_a_at CEP70 centrosomal protein 70kDa -0.51 3.2E-03 7.5E-02 214693_x_at LOC101059961 neuroblastoma breakpoint family member 21-like -0.51 3.2E-03 7.5E-02 201317_s_at PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.51 3.2E-03 7.5E-02 221700_s_at UBA52 ubiquitin A-52 residue ribosomal protein fusion 1 -0.51 3.2E-03 7.5E-02 202179_at BLMH bleomycin -0.51 3.2E-03 7.5E-02 209786_at HMGN4 high mobility group nucleosomal binding domain 4 -0.51 3.2E-03 7.5E-02 202348_s_at TOR1A torsin family 1, member A (torsin A) -0.51 3.2E-03 7.5E-02 202092_s_at ARL2BP ADP-ribosylation factor-like 2 binding protein -0.51 3.3E-03 7.5E-02 218673_s_at ATG7 autophagy related 7 -0.51 3.3E-03 7.5E-02 223476_s_at C12orf65 chromosome 12 open reading frame 65 -0.51 3.3E-03 7.5E-02 212515_s_at DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked -0.51 3.3E-03 7.5E-02 234405_s_at PHAX phosphorylated adaptor for RNA export -0.51 3.3E-03 7.5E-02 203884_s_at RAB11FIP2 RAB11 family interacting protein 2 (class I) -0.51 3.3E-03 7.5E-02 212009_s_at STIP1 stress-induced-phosphoprotein 1 -0.51 3.3E-03 7.5E-02 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 226037_s_at TAF9B -0.51 3.3E-03 7.5E-02 31kDa 203589_s_at TFDP2 transcription factor Dp-2 ( dimerization partner 2) -0.51 3.3E-03 7.5E-02 208971_at UROD uroporphyrinogen decarboxylase -0.51 3.3E-03 7.5E-02 200848_at AHCYL1 adenosylhomocysteinase-like 1 -0.51 3.3E-03 7.5E-02 225443_at DCP1A decapping mRNA 1A -0.51 3.3E-03 7.5E-02 225310_at RBMX RNA binding motif protein, X-linked -0.51 3.3E-03 7.5E-02 204125_at NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -0.51 3.3E-03 7.5E-02 205961_s_at PSIP1 PC4 and SFRS1 interacting protein 1 -0.51 3.3E-03 7.5E-02 224806_at TRIM25 tripartite motif containing 25 -0.51 3.3E-03 7.5E-02 213009_s_at TRIM37 tripartite motif containing 37 -0.51 3.3E-03 7.5E-02 1553976_a_at DPCD deleted in primary ciliary dyskinesia homolog (mouse) -0.51 3.3E-03 7.5E-02 218297_at FAM188A family with sequence similarity 188, member A -0.51 3.3E-03 7.5E-02 1557372_at ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 -0.51 3.3E-03 7.5E-02 206748_s_at SPAG9 sperm associated 9 -0.51 3.3E-03 7.5E-02 241666_at TCAIM activation inhibitor, mitochondrial -0.51 3.3E-03 7.5E-02 220250_at ZNF286A zinc finger protein 286A -0.51 3.3E-03 7.5E-02 208696_at CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.51 3.3E-03 7.5E-02 200978_at MDH1 malate dehydrogenase 1, NAD (soluble) -0.51 3.3E-03 7.5E-02 221965_at OTTHUMG00000168850 NULL -0.51 3.3E-03 7.5E-02 202226_s_at CRK v-crk sarcoma virus CT10 oncogene homolog (avian) -0.51 3.4E-03 7.6E-02 1559444_at ------0.51 3.4E-03 7.6E-02 200607_s_at RAD21 RAD21 homolog (S. pombe) -0.51 3.4E-03 7.6E-02 201351_s_at YME1L1 YME1-like 1 ATPase -0.51 3.4E-03 7.6E-02 1555735_a_at BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) -0.51 3.4E-03 7.6E-02 218073_s_at NDC1 NDC1 transmembrane nucleoporin -0.51 3.4E-03 7.6E-02 234299_s_at NIN ninein (GSK3B interacting protein) -0.51 3.4E-03 7.6E-02 208616_s_at PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.51 3.4E-03 7.6E-02

9 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value SWI/SNF related, matrix associated, actin dependent regulator of chromatin, 201073_s_at SMARCC1 -0.51 3.4E-03 7.6E-02 subfamily c, member 1 212880_at WDR7 WD repeat domain 7 -0.51 3.4E-03 7.6E-02 201947_s_at CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.51 3.4E-03 7.6E-02 235552_at METTL14 methyltransferase like 14 -0.51 3.4E-03 7.6E-02 228245_s_at LOC100509445 uncharacterized LOC100509445 -0.51 3.4E-03 7.6E-02 218449_at UFSP2 UFM1-specific peptidase 2 -0.51 3.4E-03 7.6E-02 202749_at WRB tryptophan rich basic protein -0.51 3.4E-03 7.6E-02 209953_s_at CDC37 cell division cycle 37 -0.51 3.5E-03 7.6E-02 1557218_s_at FANCB Fanconi anemia, complementation group B -0.51 3.5E-03 7.6E-02 203033_x_at FH fumarate hydratase -0.51 3.5E-03 7.6E-02 207157_s_at GNG5 guanine nucleotide binding protein (G protein), gamma 5 -0.51 3.5E-03 7.6E-02 211797_s_at NFYC nuclear transcription factor Y, gamma -0.51 3.5E-03 7.6E-02 200627_at PTGES3 prostaglandin E synthase 3 (cytosolic) -0.51 3.5E-03 7.6E-02 241343_at RNASEH1 ribonuclease H1 -0.51 3.5E-03 7.6E-02 218514_at SMG8 smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) -0.51 3.5E-03 7.6E-02 223758_s_at GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -0.51 3.5E-03 7.7E-02 221258_s_at KIF18A kinesin family member 18A -0.51 3.5E-03 7.7E-02 202122_s_at PLIN3 perilipin 3 -0.51 3.5E-03 7.7E-02 226151_x_at CRYZL1 crystallin, zeta (quinone reductase)-like 1 -0.51 3.5E-03 7.7E-02 1558173_a_at LUZP1 leucine zipper protein 1 -0.51 3.5E-03 7.7E-02 1553510_s_at RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) -0.51 3.5E-03 7.7E-02 206667_s_at SCAMP1 secretory carrier membrane protein 1 -0.51 3.5E-03 7.7E-02 222503_s_at WDR41 WD repeat domain 41 -0.51 3.5E-03 7.7E-02 205835_s_at YTHDC2 YTH domain containing 2 -0.51 3.5E-03 7.7E-02 223230_at PRPF38A PRP38 pre-mRNA processing factor 38 (yeast) domain containing A -0.51 3.6E-03 7.7E-02 79005_at SLC35E1 solute carrier family 35, member E1 -0.51 3.6E-03 7.7E-02 AFFX- HUMISGF3A/M STAT1 signal transducer and activator of transcription 1, 91kDa -0.51 3.6E-03 7.7E-02 97935_MB_at 233878_s_at XRN2 5'-3' exoribonuclease 2 -0.51 3.6E-03 7.7E-02 205061_s_at EXOSC9 exosome component 9 -0.51 3.6E-03 7.7E-02 209449_at LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.51 3.6E-03 7.7E-02 1554053_at SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -0.51 3.6E-03 7.7E-02 224985_at NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -0.51 3.6E-03 7.7E-02 200667_at UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.51 3.6E-03 7.7E-02 225735_at ANKRD50 ankyrin repeat domain 50 -0.51 3.6E-03 7.8E-02 201089_at ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -0.51 3.6E-03 7.8E-02 203968_s_at cell division cycle 6 -0.51 3.6E-03 7.8E-02 224605_at C4orf3 chromosome 4 open reading frame 3 -0.51 3.7E-03 7.8E-02 1554464_a_at CRTAP cartilage associated protein -0.51 3.7E-03 7.8E-02

200651_at GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 -0.51 3.7E-03 7.8E-02

202050_s_at ZMYM4 zinc finger, MYM-type 4 -0.51 3.7E-03 7.8E-02 226331_at BBX bobby sox homolog (Drosophila) -0.51 3.7E-03 7.8E-02 202467_s_at COPS2 COP9 signalosome subunit 2 -0.51 3.7E-03 7.8E-02 235011_at MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.51 3.7E-03 7.8E-02 228505_s_at TMEM170A transmembrane protein 170A -0.51 3.7E-03 7.8E-02 211749_s_at VAMP3 vesicle-associated membrane protein 3 -0.51 3.7E-03 7.8E-02 228427_at FBXO16 F-box protein 16 -0.51 3.7E-03 7.8E-02 202443_x_at NOTCH2 notch 2 -0.51 3.7E-03 7.8E-02 1554153_a_at PHF21A PHD finger protein 21A -0.51 3.7E-03 7.8E-02 225014_at SMIM20 small integral membrane protein 20 -0.51 3.7E-03 7.8E-02 220199_s_at AIDA axin interactor, dorsalization associated -0.50 3.8E-03 7.9E-02 224875_at C5orf24 chromosome 5 open reading frame 24 -0.50 3.8E-03 7.9E-02 241689_at ------0.50 3.8E-03 7.9E-02 208739_x_at SUMO2 small ubiquitin-like modifier 2 -0.50 3.8E-03 7.9E-02 222578_s_at UBA5 ubiquitin-like modifier activating enzyme 5 -0.50 3.8E-03 7.9E-02 212597_s_at HMGXB4 HMG box domain containing 4 -0.50 3.8E-03 7.9E-02 221531_at WDR61 WD repeat domain 61 -0.50 3.8E-03 7.9E-02 223108_s_at ZCCHC17 zinc finger, CCHC domain containing 17 -0.50 3.8E-03 7.9E-02 1554451_s_at DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 -0.50 3.8E-03 7.9E-02 1564467_at FAM161A family with sequence similarity 161, member A -0.50 3.8E-03 7.9E-02 220651_s_at MCM10 minichromosome maintenance complex component 10 -0.50 3.8E-03 7.9E-02 225225_at OIP5-AS1 OIP5 antisense RNA 1 -0.50 3.8E-03 7.9E-02 223053_x_at SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -0.50 3.8E-03 7.9E-02 201230_s_at ARIH2 ariadne homolog 2 (Drosophila) -0.50 3.9E-03 7.9E-02 202164_s_at CNOT8 CCR4-NOT transcription complex, subunit 8 -0.50 3.9E-03 7.9E-02 201376_s_at HNRNPF heterogeneous nuclear ribonucleoprotein F -0.50 3.9E-03 7.9E-02 227273_at ------0.50 3.9E-03 8.0E-02 213331_s_at NEK1 NIMA-related kinase 1 -0.50 3.9E-03 8.0E-02 218304_s_at OSBPL11 oxysterol binding protein-like 11 -0.50 3.9E-03 8.0E-02 244052_at CBR4 carbonyl reductase 4 -0.50 3.9E-03 8.0E-02 211814_s_at CCNE2 cyclin E2 -0.50 3.9E-03 8.0E-02 223281_s_at COX15 oxidase assembly homolog 15 (yeast) -0.50 3.9E-03 8.0E-02 201845_s_at RYBP RING1 and YY1 binding protein -0.50 3.9E-03 8.0E-02 221562_s_at SIRT3 3 -0.50 3.9E-03 8.0E-02 203846_at TRIM32 tripartite motif containing 32 -0.50 3.9E-03 8.0E-02 223331_s_at DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 -0.50 4.0E-03 8.0E-02 208750_s_at ARF1 ADP-ribosylation factor 1 -0.50 4.0E-03 8.0E-02 242434_at ------0.50 4.0E-03 8.0E-02 218705_s_at SNX24 sorting nexin 24 -0.50 4.0E-03 8.0E-02 208787_at MRPL3 mitochondrial ribosomal protein L3 -0.50 4.0E-03 8.0E-02 222611_s_at PSPC1 paraspeckle component 1 -0.50 4.0E-03 8.0E-02 202333_s_at UBE2B ubiquitin-conjugating enzyme E2B -0.50 4.0E-03 8.0E-02 223002_s_at XRN2 5'-3' exoribonuclease 2 -0.50 4.0E-03 8.0E-02 205917_at ZNF264 zinc finger protein 264 -0.50 4.0E-03 8.0E-02 221826_at ANGEL2 angel homolog 2 (Drosophila) -0.50 4.0E-03 8.0E-02 210012_s_at EWSR1 EWS RNA-binding protein 1 -0.50 4.0E-03 8.0E-02 222111_at FAM63B family with sequence similarity 63, member B -0.50 4.0E-03 8.0E-02 200869_at RPL18A ribosomal protein L18a -0.50 4.0E-03 8.0E-02 230050_at NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -0.50 4.0E-03 8.0E-02

10 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 204887_s_at PLK4 polo-like kinase 4 -0.50 4.0E-03 8.0E-02 214512_s_at SUB1 SUB1 homolog (S. cerevisiae) -0.50 4.0E-03 8.0E-02 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein 1567458_s_at RAC1 -0.50 4.1E-03 8.1E-02 Rac1)

201727_s_at ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) -0.50 4.1E-03 8.1E-02

218785_s_at IFT22 RAB, member RAS oncogene family-like 5 -0.50 4.1E-03 8.1E-02 244641_at MALSU1 mitochondrial assembly of ribosomal large subunit 1 -0.50 4.1E-03 8.1E-02 232515_at ------0.50 4.1E-03 8.2E-02 231918_s_at GFM2 G elongation factor, mitochondrial 2 -0.50 4.1E-03 8.2E-02 214975_s_at MTMR1 myotubularin related protein 1 -0.50 4.1E-03 8.2E-02 222738_at CLDN22 claudin 22 -0.50 4.1E-03 8.2E-02 202049_s_at ZMYM4 zinc finger, MYM-type 4 -0.50 4.1E-03 8.2E-02 204768_s_at FEN1 flap structure-specific endonuclease 1 -0.50 4.2E-03 8.2E-02 229519_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.50 4.2E-03 8.2E-02 213555_at RWDD2A RWD domain containing 2A -0.50 4.2E-03 8.2E-02 209754_s_at TMPO thymopoietin -0.50 4.2E-03 8.2E-02 1567107_s_at TPM4 tropomyosin 4 -0.50 4.2E-03 8.2E-02 1554132_a_at CCSER2 coiled-coil serine-rich protein 2 -0.50 4.2E-03 8.2E-02 204252_at CDK2 cyclin-dependent kinase 2 -0.50 4.2E-03 8.2E-02 233496_s_at CFL2 cofilin 2 (muscle) -0.50 4.2E-03 8.2E-02 207030_s_at CSRP2 cysteine and -rich protein 2 -0.50 4.2E-03 8.2E-02 235645_at ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.50 4.2E-03 8.2E-02 225477_s_at NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.50 4.2E-03 8.2E-02 37433_at PIAS2 protein inhibitor of activated STAT, 2 -0.50 4.2E-03 8.2E-02 205621_at ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -0.50 4.3E-03 8.2E-02 228323_at CASC5 cancer susceptibility candidate 5 -0.50 4.3E-03 8.2E-02 220643_s_at FAIM Fas apoptotic inhibitory molecule -0.50 4.3E-03 8.2E-02 200751_s_at HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.50 4.3E-03 8.2E-02 212016_s_at MIR4745 microRNA 4745 -0.50 4.3E-03 8.2E-02 1560339_s_at NAP1L4 nucleosome assembly protein 1-like 4 -0.50 4.3E-03 8.2E-02 238081_at WDFY3-AS2 WDFY3 antisense RNA 2 -0.50 4.3E-03 8.2E-02 219925_at ZMYM6 zinc finger, MYM-type 6 -0.50 4.3E-03 8.2E-02 228249_at C11orf74 chromosome 11 open reading frame 74 -0.50 4.3E-03 8.2E-02 216652_s_at DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -0.50 4.3E-03 8.2E-02 225084_at EXOC5 exocyst complex component 5 -0.50 4.3E-03 8.2E-02 218117_at RBX1 ring-box 1, E3 ubiquitin protein ligase -0.50 4.3E-03 8.2E-02 206668_s_at SCAMP1 secretory carrier membrane protein 1 -0.50 4.3E-03 8.2E-02 212107_s_at DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.50 4.3E-03 8.3E-02 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); 205408_at MLLT10 -0.50 4.3E-03 8.3E-02 translocated to, 10 204186_s_at PPID peptidylprolyl isomerase D -0.50 4.3E-03 8.3E-02 216125_s_at RANBP9 RAN binding protein 9 -0.50 4.3E-03 8.3E-02 200828_s_at ZNF207 zinc finger protein 207 -0.50 4.3E-03 8.3E-02 222776_at MAGOHB mago-nashi homolog B (Drosophila) -0.50 4.4E-03 8.3E-02 222522_x_at MRPS10 mitochondrial ribosomal protein S10 -0.50 4.4E-03 8.3E-02 218775_s_at CLDN22 claudin 22 -0.50 4.4E-03 8.3E-02 217786_at PRMT5 protein arginine methyltransferase 5 -0.50 4.4E-03 8.3E-02 201663_s_at SMC4 structural maintenance of chromosomes 4 -0.50 4.4E-03 8.3E-02 230435_at FAM228B family with sequence similarity 228, member B -0.50 4.4E-03 8.3E-02 203960_s_at HSPB11 heat shock protein family B (small), member 11 -0.50 4.4E-03 8.3E-02 235476_at TRIM59 tripartite motif containing 59 -0.50 4.4E-03 8.3E-02 209284_s_at FAM208A family with sequence similarity 208, member A -0.50 4.4E-03 8.4E-02 227568_at HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -0.50 4.4E-03 8.4E-02 224247_s_at MRPS10 mitochondrial ribosomal protein S10 -0.50 4.4E-03 8.4E-02 208832_at ATXN10 ataxin 10 -0.50 4.5E-03 8.4E-02 219022_at C12orf43 chromosome 12 open reading frame 43 -0.50 4.5E-03 8.4E-02 230201_at FXR1 fragile X mental retardation, autosomal homolog 1 -0.50 4.5E-03 8.4E-02 213372_at PAQR3 progestin and adipoQ receptor family member III -0.50 4.5E-03 8.4E-02 218667_at PJA1 praja ring finger 1, E3 ubiquitin protein ligase -0.50 4.5E-03 8.4E-02 225659_at SPOPL speckle-type POZ protein-like -0.50 4.5E-03 8.4E-02 208848_at ADH5 dehydrogenase 5 (class III), chi polypeptide -0.50 4.5E-03 8.4E-02 221255_s_at EMC6 ER membrane protein complex subunit 6 -0.50 4.5E-03 8.4E-02 1556301_at LOC100287015 uncharacterized LOC100287015 -0.50 4.5E-03 8.4E-02 217816_s_at PCNP PEST proteolytic signal containing nuclear protein -0.50 4.5E-03 8.4E-02 210896_s_at ASPH aspartate beta-hydroxylase -0.50 4.5E-03 8.5E-02 228033_at E2F7 E2F transcription factor 7 -0.50 4.5E-03 8.5E-02 210154_at ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -0.50 4.5E-03 8.5E-02 210466_s_at SERBP1 SERPINE1 mRNA binding protein 1 -0.50 4.5E-03 8.5E-02 205072_s_at XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.50 4.6E-03 8.5E-02 TAM41, mitochondrial translocator assembly and maintenance protein, homolog 226815_at TAMM41 -0.50 4.6E-03 8.6E-02 (S. cerevisiae) 222387_s_at VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -0.50 4.6E-03 8.6E-02 1553725_s_at ZNF644 zinc finger protein 644 -0.50 4.6E-03 8.6E-02 214710_s_at CCNB1 cyclin B1 -0.49 4.7E-03 8.6E-02 207922_s_at MAEA macrophage erythroblast attacher -0.49 4.7E-03 8.6E-02 227761_at MYO5A myosin VA (heavy chain 12, myoxin) -0.49 4.7E-03 8.6E-02 233446_at ONECUT2 one cut homeobox 2 -0.49 4.7E-03 8.6E-02 220924_s_at SLC38A2 solute carrier family 38, member 2 -0.49 4.7E-03 8.6E-02 204527_at MYO5A myosin VA (heavy chain 12, myoxin) -0.49 4.7E-03 8.6E-02 229067_at ------0.49 4.7E-03 8.6E-02 204185_x_at PPID peptidylprolyl isomerase D -0.49 4.7E-03 8.6E-02 1555679_a_at RTN4IP1 reticulon 4 interacting protein 1 -0.49 4.7E-03 8.6E-02 1554148_a_at SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.49 4.7E-03 8.6E-02 209054_s_at WHSC1 Wolf-Hirschhorn syndrome candidate 1 -0.49 4.7E-03 8.6E-02 223849_s_at MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse) -0.49 4.7E-03 8.6E-02 202732_at PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -0.49 4.7E-03 8.6E-02 214931_s_at SRPK2 SRSF protein kinase 2 -0.49 4.7E-03 8.6E-02 227768_at ZNF407 zinc finger protein 407 -0.49 4.7E-03 8.6E-02 213220_at BBIP1 BBSome interacting protein 1 -0.49 4.8E-03 8.7E-02 203082_at BMS1 BMS1 ribosome biogenesis factor -0.49 4.8E-03 8.7E-02 200099_s_at RPS3A ribosomal protein S3A -0.49 4.8E-03 8.7E-02 224896_s_at TTL tubulin tyrosine ligase -0.49 4.8E-03 8.7E-02

11 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 203776_at GPKOW G patch domain and KOW motifs -0.49 4.8E-03 8.7E-02 210104_at MED6 mediator complex subunit 6 -0.49 4.8E-03 8.7E-02 227072_at RTTN rotatin -0.49 4.8E-03 8.7E-02 208910_s_at C1QBP complement component 1, q subcomponent binding protein -0.49 4.9E-03 8.8E-02 221634_at MGC2752 CENPB DNA-binding domains containing 1 pseudogene -0.49 4.9E-03 8.8E-02 224914_s_at SARNP SAP domain containing ribonucleoprotein -0.49 4.9E-03 8.8E-02 223649_s_at SLC25A39 solute carrier family 25, member 39 -0.49 4.9E-03 8.8E-02 221452_s_at TMEM14B transmembrane protein 14B -0.49 4.9E-03 8.8E-02 X-ray repair complementing defective repair in Chinese hamster cells 5 (double- 208642_s_at XRCC5 -0.49 4.9E-03 8.8E-02 strand-break rejoining) 205371_s_at DBT dihydrolipoamide branched chain transacylase E2 -0.49 4.9E-03 8.8E-02 209592_s_at DCAF7 DDB1 and CUL4 associated factor 7 -0.49 4.9E-03 8.8E-02 1557385_at FAM161A family with sequence similarity 161, member A -0.49 4.9E-03 8.8E-02 201031_s_at HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.49 4.9E-03 8.8E-02 222393_s_at NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.49 4.9E-03 8.8E-02 203537_at PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -0.49 4.9E-03 8.8E-02 238315_s_at ZNF567 zinc finger protein 567 -0.49 4.9E-03 8.8E-02 224600_at CGGBP1 CGG triplet repeat binding protein 1 -0.49 4.9E-03 8.8E-02 excision repair cross-complementing rodent repair deficiency, complementation 235215_at ERCC4 -0.49 5.0E-03 8.9E-02 group 4 223250_at KLHL7 kelch-like family member 7 -0.49 5.0E-03 8.9E-02 203017_s_at SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.49 5.0E-03 8.9E-02 209191_at TUBB6 tubulin, beta 6 class V -0.49 5.0E-03 8.9E-02 238843_at NPHP1 nephronophthisis 1 (juvenile) -0.49 5.0E-03 8.9E-02 208447_s_at PRPS1 phosphoribosyl pyrophosphate synthetase 1 -0.49 5.0E-03 8.9E-02 236381_s_at WRAP73 WD repeat containing, antisense to TP73 -0.49 5.0E-03 8.9E-02 204605_at CGRRF1 cell growth regulator with 1 -0.49 5.1E-03 9.0E-02 213835_x_at GTPBP3 GTP binding protein 3 (mitochondrial) -0.49 5.1E-03 9.0E-02 223234_at MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) -0.49 5.1E-03 9.0E-02 1553689_s_at METTL6 methyltransferase like 6 -0.49 5.1E-03 9.0E-02 202216_x_at NFYC nuclear transcription factor Y, gamma -0.49 5.1E-03 9.0E-02 211729_x_at BLVRA reductase A -0.49 5.1E-03 9.0E-02 203418_at CCNA2 cyclin A2 -0.49 5.1E-03 9.0E-02 207590_s_at CENPI centromere protein I -0.49 5.1E-03 9.0E-02 232412_at FBXL20 F-box and leucine-rich repeat protein 20 -0.49 5.1E-03 9.0E-02 224479_s_at MRPL45 mitochondrial ribosomal protein L45 -0.49 5.1E-03 9.0E-02 201528_at RPA1 replication protein A1, 70kDa -0.49 5.1E-03 9.0E-02 218209_s_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.49 5.1E-03 9.0E-02 233827_s_at SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.49 5.1E-03 9.0E-02 209307_at SWAP70 SWAP switching B-cell complex 70kDa subunit -0.49 5.1E-03 9.0E-02 200668_s_at UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.49 5.1E-03 9.0E-02 1554441_a_at WAPAL wings apart-like homolog (Drosophila) -0.49 5.1E-03 9.0E-02 218146_at GLT8D1 glycosyltransferase 8 domain containing 1 -0.49 5.2E-03 9.0E-02 209706_at NKX3-1 NK3 homeobox 1 -0.49 5.2E-03 9.0E-02 204207_s_at RNGTT RNA and 5'-phosphatase -0.49 5.2E-03 9.0E-02 230721_at C16orf52 chromosome 16 open reading frame 52 -0.49 5.2E-03 9.1E-02 222779_s_at C17orf85 open reading frame 85 -0.49 5.2E-03 9.1E-02 219357_at GTPBP1 GTP binding protein 1 -0.49 5.2E-03 9.1E-02 200052_s_at ILF2 interleukin enhancer binding factor 2 -0.49 5.2E-03 9.1E-02 237158_s_at MPHOSPH9 M-phase phosphoprotein 9 -0.49 5.2E-03 9.1E-02 222230_s_at ACTR10 actin-related protein 10 homolog (S. cerevisiae) -0.49 5.3E-03 9.1E-02 218043_s_at AZI2 5-azacytidine induced 2 -0.49 5.3E-03 9.1E-02 217027_x_at AC004941.5 NULL -0.49 5.3E-03 9.1E-02 1552417_a_at NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.49 5.3E-03 9.1E-02 218256_s_at NUP54 nucleoporin 54kDa -0.49 5.3E-03 9.1E-02 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole 214664_at PAICS -0.49 5.3E-03 9.1E-02 succinocarboxamide synthetase 217457_s_at RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.49 5.3E-03 9.1E-02 235302_at GPATCH2L G patch domain containing 2-like -0.49 5.3E-03 9.1E-02 225878_at KIF1B kinesin family member 1B -0.49 5.3E-03 9.1E-02 200907_s_at PALLD palladin, cytoskeletal associated protein -0.49 5.3E-03 9.1E-02 212003_at SZRD1 SUZ RNA binding domain containing 1 -0.49 5.3E-03 9.1E-02 211672_s_at ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa -0.49 5.4E-03 9.1E-02 224759_s_at C12orf23 chromosome 12 open reading frame 23 -0.49 5.4E-03 9.1E-02 222645_s_at KCTD5 potassium channel tetramerisation domain containing 5 -0.49 5.4E-03 9.1E-02 204173_at MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -0.49 5.4E-03 9.1E-02 235356_at NHLRC2 NHL repeat containing 2 -0.49 5.4E-03 9.1E-02 217944_at POMGNT1 protein O-linked beta1,2-N-acetylglucosaminyltransferase -0.49 5.4E-03 9.1E-02 203869_at USP46 ubiquitin specific peptidase 46 -0.49 5.4E-03 9.1E-02 223431_at BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -0.49 5.4E-03 9.2E-02 212581_x_at GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.49 5.4E-03 9.2E-02 1552623_at HSH2D hematopoietic SH2 domain containing -0.49 5.4E-03 9.2E-02 204300_at PET112 PET112 homolog (yeast) -0.49 5.4E-03 9.2E-02 1554807_a_at SPIRE1 spire homolog 1 (Drosophila) -0.49 5.4E-03 9.2E-02 204832_s_at BMPR1A bone morphogenetic protein receptor, type IA -0.49 5.5E-03 9.2E-02 208055_s_at HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.49 5.5E-03 9.2E-02 201606_s_at PWP1 PWP1 homolog (S. cerevisiae) -0.49 5.5E-03 9.2E-02 224068_x_at RBM22 RNA binding motif protein 22 -0.49 5.5E-03 9.2E-02 203740_at MPHOSPH6 M-phase phosphoprotein 6 -0.49 5.5E-03 9.2E-02 217919_s_at MRPL42 mitochondrial ribosomal protein L42 -0.49 5.5E-03 9.2E-02 203732_at TRIP4 thyroid hormone receptor interactor 4 -0.49 5.5E-03 9.2E-02 1555039_a_at ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.49 5.5E-03 9.3E-02 208945_s_at BECN1 beclin 1, autophagy related -0.49 5.5E-03 9.3E-02 1554149_at CLDND1 claudin domain containing 1 -0.49 5.5E-03 9.3E-02 203302_at DCK -0.49 5.5E-03 9.3E-02 223046_at EGLN1 egl nine homolog 1 (C. elegans) -0.49 5.5E-03 9.3E-02 210758_at PSIP1 PC4 and SFRS1 interacting protein 1 -0.49 5.6E-03 9.3E-02 203764_at DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.49 5.6E-03 9.4E-02 227628_at GPX8 glutathione peroxidase 8 (putative) -0.49 5.6E-03 9.4E-02 217805_at ILF3 interleukin enhancer binding factor 3, 90kDa -0.49 5.6E-03 9.4E-02 215073_s_at NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.49 5.6E-03 9.4E-02 224470_at SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -0.49 5.6E-03 9.4E-02 222516_at AP3M1 adaptor-related protein complex 3, mu 1 subunit -0.49 5.7E-03 9.4E-02

12 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 225798_at JAZF1 JAZF zinc finger 1 -0.49 5.7E-03 9.4E-02 214709_s_at KTN1 kinectin 1 (kinesin receptor) -0.49 5.7E-03 9.4E-02 215434_x_at NBPF1 neuroblastoma breakpoint family, member 1 -0.49 5.7E-03 9.4E-02

216941_s_at TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.49 5.7E-03 9.4E-02

201434_at TTC1 tetratricopeptide repeat domain 1 -0.49 5.7E-03 9.4E-02 215991_s_at EMC1 ER membrane protein complex subunit 1 -0.48 5.7E-03 9.4E-02 229297_at GPATCH2L G patch domain containing 2-like -0.48 5.7E-03 9.4E-02 234304_s_at IPO11 importin 11 -0.48 5.7E-03 9.4E-02 214442_s_at PIAS2 protein inhibitor of activated STAT, 2 -0.48 5.7E-03 9.4E-02 235120_at SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -0.48 5.7E-03 9.4E-02 237515_at TMEM56 transmembrane protein 56 -0.48 5.7E-03 9.4E-02 201921_at GNG10 guanine nucleotide binding protein (G protein), gamma 10 -0.48 5.8E-03 9.5E-02 220946_s_at SETD2 SET domain containing 2 -0.48 5.8E-03 9.5E-02 1561965_at SNRPB2 small nuclear ribonucleoprotein polypeptide B -0.48 5.8E-03 9.5E-02 204720_s_at DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.48 5.8E-03 9.5E-02 205945_at IL6R interleukin 6 receptor -0.48 5.8E-03 9.5E-02 1554768_a_at MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.48 5.8E-03 9.5E-02 211017_s_at NF2 neurofibromin 2 () -0.48 5.8E-03 9.5E-02 210574_s_at NUDC nuclear distribution C homolog (A. nidulans) -0.48 5.8E-03 9.5E-02 203696_s_at RFC2 replication factor C (activator 1) 2, 40kDa -0.48 5.8E-03 9.5E-02 1557388_at RTTN rotatin -0.48 5.8E-03 9.5E-02 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), 200657_at SLC25A5 -0.48 5.8E-03 9.5E-02 member 5 202779_s_at UBE2S ubiquitin-conjugating enzyme E2S -0.48 5.8E-03 9.5E-02 200812_at CCT7 chaperonin containing TCP1, subunit 7 (eta) -0.48 5.9E-03 9.5E-02 226048_at MAPK8 mitogen-activated protein kinase 8 -0.48 5.9E-03 9.5E-02 209861_s_at METAP2 methionyl 2 -0.48 5.9E-03 9.5E-02 202731_at MIR4680 microRNA 4680 -0.48 5.9E-03 9.5E-02 215743_at NMT2 N-myristoyltransferase 2 -0.48 5.9E-03 9.5E-02 1555529_at RNH1 ribonuclease/ inhibitor 1 -0.48 5.9E-03 9.5E-02 222074_at UROD uroporphyrinogen decarboxylase -0.48 5.9E-03 9.5E-02 217911_s_at BAG3 BCL2-associated athanogene 3 -0.48 5.9E-03 9.5E-02 226109_at C21orf91 chromosome 21 open reading frame 91 -0.48 5.9E-03 9.5E-02 210559_s_at CDK1 cyclin-dependent kinase 1 -0.48 5.9E-03 9.5E-02 222151_s_at CEP63 centrosomal protein 63kDa -0.48 5.9E-03 9.5E-02 216554_s_at ENO1 enolase 1, (alpha) -0.48 5.9E-03 9.5E-02 221813_at FBXO42 F-box protein 42 -0.48 5.9E-03 9.5E-02 219843_at IPP intracisternal A particle-promoted polypeptide -0.48 5.9E-03 9.5E-02 218226_s_at NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -0.48 5.9E-03 9.5E-02 204325_s_at NF1 -0.48 5.9E-03 9.5E-02 209264_s_at TSPAN4 4 -0.48 5.9E-03 9.5E-02 232296_s_at GFM1 G elongation factor, mitochondrial 1 -0.48 6.0E-03 9.5E-02 223236_at NSRP1 nuclear speckle splicing regulatory protein 1 -0.48 6.0E-03 9.5E-02 208456_s_at RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.48 6.0E-03 9.5E-02 225138_at ZRANB1 zinc finger, RAN-binding domain containing 1 -0.48 6.0E-03 9.5E-02 223097_at ADPRHL2 ADP-ribosylhydrolase like 2 -0.48 6.0E-03 9.6E-02 201077_s_at ANXA2 annexin A2 -0.48 6.0E-03 9.6E-02 219292_at THAP1 THAP domain containing, apoptosis associated protein 1 -0.48 6.0E-03 9.6E-02 37226_at BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -0.48 6.1E-03 9.6E-02 235378_at FAM161B family with sequence similarity 161, member B -0.48 6.1E-03 9.6E-02 229673_at GPATCH2L G patch domain containing 2-like -0.48 6.1E-03 9.6E-02 219338_s_at LRRC49 leucine rich repeat containing 49 -0.48 6.1E-03 9.6E-02 202810_at DRG1 developmentally regulated GTP binding protein 1 -0.48 6.1E-03 9.7E-02 213434_at STX2 syntaxin 2 -0.48 6.1E-03 9.7E-02 224602_at C4orf3 chromosome 4 open reading frame 3 -0.48 6.2E-03 9.7E-02 200596_s_at EIF3A eukaryotic translation initiation factor 3, subunit A -0.48 6.2E-03 9.7E-02 210110_x_at HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.48 6.2E-03 9.7E-02 218041_x_at SLC38A2 solute carrier family 38, member 2 -0.48 6.2E-03 9.7E-02 220961_s_at TBRG4 transforming growth factor beta regulator 4 -0.48 6.2E-03 9.7E-02 205791_x_at ZNF230 zinc finger protein 230 -0.48 6.2E-03 9.7E-02 221679_s_at ABHD6 abhydrolase domain containing 6 -0.48 6.2E-03 9.7E-02 202190_at CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -0.48 6.2E-03 9.7E-02 226009_at DPCD deleted in primary ciliary dyskinesia homolog (mouse) -0.48 6.2E-03 9.7E-02 201123_s_at EIF5A eukaryotic translation initiation factor 5A -0.48 6.2E-03 9.7E-02 1554670_at GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -0.48 6.2E-03 9.7E-02 235606_at LINC00883 long intergenic non-protein coding RNA 883 -0.48 6.2E-03 9.7E-02 224629_at LMAN1 lectin, mannose-binding, 1 -0.48 6.2E-03 9.7E-02 227386_s_at TMEM200B transmembrane protein 200B -0.48 6.2E-03 9.7E-02 215708_s_at PRIM2 DNA primase large subunit-like -0.48 6.2E-03 9.7E-02 238041_at TCF12 transcription factor 12 -0.48 6.2E-03 9.7E-02 202173_s_at VEZF1 vascular endothelial zinc finger 1 -0.48 6.2E-03 9.7E-02 212804_s_at GAPVD1 GTPase activating protein and VPS9 domains 1 -0.48 6.3E-03 9.7E-02 231812_x_at PHAX phosphorylated adaptor for RNA export -0.48 6.3E-03 9.8E-02 202754_at R3HDM1 R3H domain containing 1 -0.48 6.3E-03 9.8E-02 241808_at ZC2HC1A zinc finger, C2HC-type containing 1A -0.48 6.3E-03 9.8E-02 229119_s_at ZSWIM7 zinc finger, SWIM-type containing 7 -0.48 6.3E-03 9.8E-02 212180_at CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like -0.48 6.4E-03 9.8E-02 1565717_s_at FUS fused in sarcoma -0.48 6.4E-03 9.8E-02 202082_s_at SEC14L1 SEC14-like 1 (S. cerevisiae) -0.48 6.4E-03 9.8E-02 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 200641_s_at YWHAZ -0.48 6.4E-03 9.8E-02 zeta polypeptide 224593_at ZNF664 zinc finger protein 664 -0.48 6.4E-03 9.8E-02 203115_at FECH ferrochelatase -0.48 6.4E-03 9.8E-02 1559658_at KATNBL1 katanin p80 subunit B-like 1 -0.48 6.4E-03 9.8E-02 223156_at MRPS23 mitochondrial ribosomal protein S23 -0.48 6.4E-03 9.8E-02 209434_s_at PPAT phosphoribosyl pyrophosphate amidotransferase -0.48 6.4E-03 9.8E-02 221547_at PRPF18 pre-mRNA processing factor 18 -0.48 6.4E-03 9.8E-02 224787_s_at RAB18 RAB18, member RAS oncogene family -0.48 6.4E-03 9.8E-02 219636_s_at ARMC9 armadillo repeat containing 9 -0.48 6.5E-03 9.9E-02 212738_at ARHGAP19 Rho GTPase activating protein 19 -0.48 6.5E-03 9.9E-02 207829_s_at BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -0.48 6.5E-03 9.9E-02 201385_at DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.48 6.5E-03 9.9E-02

13 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 218626_at EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -0.48 6.5E-03 9.9E-02 200745_s_at GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.48 6.5E-03 9.9E-02 1569312_at ------0.48 6.5E-03 9.9E-02 238011_at OTTHUMG00000178148 NULL -0.48 6.5E-03 9.9E-02 222514_at RRAGC Ras-related GTP binding C -0.48 6.5E-03 9.9E-02 203217_s_at ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -0.48 6.5E-03 9.9E-02 1555436_a_at AFF4 AF4/FMR2 family, member 4 -0.48 6.6E-03 9.9E-02 235266_at ATAD2 ATPase family, AAA domain containing 2 -0.48 6.6E-03 9.9E-02 219267_at GLTP glycolipid transfer protein -0.48 6.6E-03 9.9E-02 226881_at GRPEL2 GrpE-like 2, mitochondrial (E. coli) -0.48 6.6E-03 9.9E-02 211725_s_at BID BH3 interacting domain death agonist -0.48 6.6E-03 9.9E-02 202077_at NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -0.48 6.6E-03 9.9E-02 234980_at TMEM56 transmembrane protein 56 -0.48 6.6E-03 9.9E-02 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 200693_at YWHAQ -0.48 6.6E-03 9.9E-02 theta polypeptide 227918_s_at ZYG11B zyg-11 family member B, cell cycle regulator -0.48 6.6E-03 9.9E-02 1552306_at ALG10 ALG10, alpha-1,2-glucosyltransferase -0.48 6.6E-03 9.9E-02 227337_at ANKRD37 ankyrin repeat domain 37 -0.48 6.6E-03 9.9E-02 203044_at CHSY1 chondroitin sulfate synthase 1 -0.48 6.6E-03 9.9E-02 218025_s_at ECI2 enoyl-CoA delta isomerase 2 -0.48 6.6E-03 9.9E-02 210912_x_at GSTM4 glutathione S-transferase mu 4 -0.48 6.6E-03 9.9E-02 238001_at KCTD6 potassium channel tetramerisation domain containing 6 -0.48 6.6E-03 9.9E-02 206174_s_at PPP6C protein phosphatase 6, catalytic subunit -0.48 6.6E-03 9.9E-02 242335_at SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.48 6.6E-03 9.9E-02 221532_s_at WDR61 WD repeat domain 61 -0.48 6.6E-03 9.9E-02 232197_x_at ARSB B -0.48 6.7E-03 1.0E-01 203595_s_at IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -0.48 6.7E-03 1.0E-01 201571_s_at DCTD dCMP deaminase -0.48 6.7E-03 1.0E-01 201142_at EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.48 6.7E-03 1.0E-01 227270_at FAM200B family with sequence similarity 200, member B -0.48 6.7E-03 1.0E-01 1556913_a_at GIT2 NULL -0.48 6.7E-03 1.0E-01 210759_s_at PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.48 6.7E-03 1.0E-01 222527_s_at RBM22 RNA binding motif protein 22 -0.48 6.7E-03 1.0E-01 222893_s_at RPAP2 RNA polymerase II associated protein 2 -0.48 6.7E-03 1.0E-01 202675_at SDHB complex, subunit B, iron sulfur (Ip) -0.48 6.7E-03 1.0E-01 225731_at ANKRD50 ankyrin repeat domain 50 -0.48 6.8E-03 1.0E-01 210027_s_at APEX1 APEX (multifunctional DNA repair enzyme) 1 -0.48 6.8E-03 1.0E-01 231979_at ------0.48 6.8E-03 1.0E-01 221883_at PKNOX1 PBX/knotted 1 homeobox 1 -0.48 6.8E-03 1.0E-01 221753_at SSH1 slingshot -0.48 6.8E-03 1.0E-01 224878_at UBFD1 ubiquitin family domain containing 1 -0.48 6.8E-03 1.0E-01 207730_x_at ------0.48 6.8E-03 1.0E-01 242645_at ------0.48 6.8E-03 1.0E-01 241669_x_at PRKD2 protein kinase D2 0.48 6.8E-03 1.0E-01 236715_x_at UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.48 6.8E-03 1.0E-01 207555_s_at TBXA2R thromboxane A2 receptor 0.48 6.7E-03 1.0E-01 pleckstrin homology domain containing, family G (with RhoGef domain) member 212823_s_at PLEKHG3 0.48 6.7E-03 1.0E-01 3 212888_at DICER1 1, ribonuclease type III 0.48 6.6E-03 9.9E-02 213206_at GOSR2 golgi SNAP receptor complex member 2 0.48 6.6E-03 9.9E-02 242111_at METTL3 methyltransferase like 3 0.48 6.6E-03 9.9E-02 211066_x_at PCDHGA1 protocadherin gamma subfamily A, 1 0.48 6.6E-03 9.9E-02 233089_at QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.48 6.6E-03 9.9E-02 227698_s_at RAB40C RAB40C, member RAS oncogene family 0.48 6.6E-03 9.9E-02 224979_s_at USP36 ubiquitin specific peptidase 36 0.48 6.6E-03 9.9E-02 223287_s_at FOXP1 forkhead box P1 0.48 6.5E-03 9.9E-02 231552_at ------0.48 6.5E-03 9.9E-02 242362_at ------0.48 6.5E-03 9.9E-02 207309_at NOS1 nitric oxide synthase 1 (neuronal) 0.48 6.5E-03 9.9E-02 219192_at UBAP2 ubiquitin associated protein 2 0.48 6.5E-03 9.9E-02 202281_at GAK cyclin G associated kinase 0.48 6.5E-03 9.9E-02 1559128_at HSDL2 hydroxysteroid dehydrogenase like 2 0.48 6.4E-03 9.8E-02 232541_at ------0.48 6.4E-03 9.8E-02 1557275_a_at TLCD2 TLC domain containing 2 0.48 6.4E-03 9.8E-02 204573_at CROT carnitine O-octanoyltransferase 0.48 6.3E-03 9.8E-02 215604_x_at ------0.48 6.3E-03 9.7E-02 225909_at LOC728743 zinc finger protein pseudogene 0.48 6.3E-03 9.7E-02 241681_at ------0.48 6.3E-03 9.7E-02 238736_at REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.48 6.3E-03 9.7E-02 226144_at MIR1909 microRNA 1909 0.48 6.2E-03 9.7E-02 233976_at ------0.48 6.2E-03 9.7E-02 221876_at ZNF783 zinc finger family member 783 0.48 6.1E-03 9.7E-02 221245_s_at FZD5 frizzled family receptor 5 0.48 6.1E-03 9.6E-02 1558410_s_at ------0.48 6.1E-03 9.6E-02 233427_x_at ------0.48 6.1E-03 9.6E-02 241359_at TLCD2 TLC domain containing 2 0.48 6.1E-03 9.6E-02 217111_at AMACR alpha-methylacyl-CoA racemase 0.48 6.0E-03 9.6E-02 41387_r_at KDM6B lysine (K)-specific demethylase 6B 0.48 6.0E-03 9.6E-02 215909_x_at MINK1 misshapen-like kinase 1 0.48 6.0E-03 9.6E-02 229255_x_at ------0.48 6.0E-03 9.5E-02 210616_s_at SEC31A SEC31 homolog A (S. cerevisiae) 0.48 6.0E-03 9.5E-02 1568907_at ------0.48 5.9E-03 9.5E-02 209847_at CDH17 cadherin 17, LI cadherin (liver-intestine) 0.48 5.9E-03 9.5E-02 209691_s_at DOK4 docking protein 4 0.48 5.9E-03 9.5E-02 221899_at N4BP2L2 NEDD4 binding protein 2-like 2 0.48 5.9E-03 9.5E-02 204231_s_at FAAH fatty acid amide hydrolase 0.48 5.8E-03 9.5E-02 232685_at ------0.48 5.8E-03 9.5E-02 237110_at ------0.48 5.7E-03 9.4E-02 222704_at POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.49 5.7E-03 9.4E-02 239091_at ------0.49 5.6E-03 9.3E-02 211004_s_at ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.49 5.5E-03 9.3E-02 213076_at ITPKC inositol-trisphosphate 3-kinase C 0.49 5.5E-03 9.3E-02 242480_at ------0.49 5.5E-03 9.3E-02

14 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 215810_x_at DST dystonin 0.49 5.5E-03 9.3E-02 41386_i_at KDM6B lysine (K)-specific demethylase 6B 0.49 5.5E-03 9.2E-02 243216_x_at ------0.49 5.5E-03 9.2E-02 1557172_x_at NEK8 NIMA-related kinase 8 0.49 5.5E-03 9.2E-02 217534_at FAM49B family with sequence similarity 49, member B 0.49 5.5E-03 9.2E-02 202205_at VASP vasodilator-stimulated phosphoprotein 0.49 5.5E-03 9.2E-02 232722_at RNASET2 0.49 5.4E-03 9.2E-02 233874_at SLAIN2 SLAIN motif family, member 2 0.49 5.4E-03 9.2E-02 239122_at ------0.49 5.3E-03 9.1E-02 212611_at DTX4 deltex homolog 4 (Drosophila) 0.49 5.3E-03 9.1E-02 236908_at ------0.49 5.3E-03 9.1E-02 38710_at OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.49 5.3E-03 9.1E-02 232601_at ------0.49 5.2E-03 9.0E-02 222252_x_at UBQLN4 ubiquilin 4 0.49 5.2E-03 9.0E-02 217703_x_at ------0.49 5.2E-03 9.0E-02 216381_x_at AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.49 5.1E-03 9.0E-02 219694_at FAM105A family with sequence similarity 105, member A 0.49 5.1E-03 9.0E-02 227865_at IDNK idnK, gluconokinase homolog (E. coli) 0.49 5.1E-03 9.0E-02 229952_at ------0.49 5.1E-03 9.0E-02 232373_at NOXA1 NADPH oxidase activator 1 0.49 5.1E-03 9.0E-02 203973_s_at CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.49 5.0E-03 8.9E-02 236365_at AMACR alpha-methylacyl-CoA racemase 0.49 4.9E-03 8.8E-02 211464_x_at CASP6 caspase 6, apoptosis-related cysteine peptidase 0.49 4.9E-03 8.8E-02 244650_at FAM105A family with sequence similarity 105, member A 0.49 4.9E-03 8.8E-02 231057_at ------0.49 4.9E-03 8.8E-02 211184_s_at USH1C Usher syndrome 1C (autosomal recessive, severe) 0.49 4.9E-03 8.8E-02 241159_x_at ------0.49 4.9E-03 8.8E-02 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q 229647_at NDUFS1 0.49 4.8E-03 8.7E-02 reductase) 212446_s_at CERS6 ceramide synthase 6 0.49 4.7E-03 8.6E-02 234838_at ------0.49 4.7E-03 8.6E-02 215376_at ------0.49 4.7E-03 8.6E-02 220761_s_at TAOK3 TAO kinase 3 0.49 4.7E-03 8.6E-02 213390_at ZC3H4 zinc finger CCCH-type containing 4 0.49 4.7E-03 8.6E-02

211889_x_at CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary ) 0.50 4.6E-03 8.6E-02

232447_at ------0.50 4.6E-03 8.6E-02 213736_at COX5B subunit Vb 0.50 4.6E-03 8.5E-02 215063_x_at LRRC40 leucine rich repeat containing 40 0.50 4.6E-03 8.5E-02 204968_at C6orf47 chromosome 6 open reading frame 47 0.50 4.5E-03 8.5E-02 231005_at ------0.50 4.5E-03 8.4E-02 217899_at TMEM214 transmembrane protein 214 0.50 4.5E-03 8.4E-02 219946_x_at MYH14 myosin, heavy chain 14, non-muscle 0.50 4.4E-03 8.3E-02 244414_at ------0.50 4.4E-03 8.3E-02 213393_at MFSD9 major facilitator superfamily domain containing 9 0.50 4.4E-03 8.3E-02 219127_at PRR15L proline rich 15-like 0.50 4.3E-03 8.3E-02 213502_x_at GUSBP11 glucuronidase, beta pseudogene 11 0.50 4.3E-03 8.2E-02 233428_at ------0.50 4.3E-03 8.2E-02 221506_s_at TNPO2 transportin 2 0.50 4.3E-03 8.2E-02 233541_at LIMD1-AS1 LIMD1 antisense RNA 1 0.50 4.3E-03 8.2E-02 221508_at TAOK3 TAO kinase 3 0.50 4.3E-03 8.2E-02 204272_at LGALS4 lectin, galactoside-binding, soluble, 4 0.50 4.2E-03 8.2E-02 226123_at CHD7 chromodomain helicase DNA binding protein 7 0.50 4.1E-03 8.2E-02 230699_at PGLS 6-phosphogluconolactonase 0.50 4.1E-03 8.1E-02

220475_at SLC28A3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 0.50 4.1E-03 8.1E-02 pancreatic progenitor cell differentiation and proliferation factor homolog 233571_x_at PPDPF 0.50 4.0E-03 8.0E-02 () 1557170_at NEK8 NIMA-related kinase 8 0.50 4.0E-03 8.0E-02 232516_x_at DAP3 death associated protein 3 0.50 4.0E-03 8.0E-02 222521_x_at NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.50 4.0E-03 8.0E-02 210791_s_at ARHGAP32 Rho GTPase activating protein 32 0.50 3.9E-03 8.0E-02 1561195_at ------0.50 3.9E-03 8.0E-02 232778_at ------0.50 3.9E-03 8.0E-02 216229_x_at ------0.50 3.9E-03 8.0E-02 223153_x_at TMUB1 transmembrane and ubiquitin-like domain containing 1 0.50 3.9E-03 8.0E-02 201839_s_at EPCAM epithelial cell adhesion molecule 0.50 3.9E-03 7.9E-02 241996_at ------0.50 3.9E-03 7.9E-02 232221_x_at RSBN1L round spermatid basic protein 1-like 0.50 3.8E-03 7.9E-02 224627_at GBA2 glucosidase, beta (bile acid) 2 0.50 3.8E-03 7.9E-02 242861_at NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.50 3.8E-03 7.9E-02 243808_at ------0.50 3.8E-03 7.9E-02 217866_at CPSF7 cleavage and specific factor 7, 59kDa 0.50 3.8E-03 7.9E-02 242730_at MYRIP myosin VIIA and Rab interacting protein 0.50 3.8E-03 7.9E-02 227334_at USP54 ubiquitin specific peptidase 54 0.50 3.8E-03 7.9E-02 215235_at SPTAN1 spectrin, alpha, non-erythrocytic 1 0.51 3.7E-03 7.8E-02 223895_s_at EPN3 epsin 3 0.51 3.7E-03 7.8E-02 221884_at MECOM MDS1 and EVI1 complex 0.51 3.7E-03 7.8E-02 212044_s_at RPL27A ribosomal protein L27a 0.51 3.7E-03 7.8E-02 220728_at ------0.51 3.6E-03 7.8E-02 236010_at ------0.51 3.6E-03 7.8E-02

216200_at PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.51 3.6E-03 7.8E-02

239907_at ------0.51 3.6E-03 7.7E-02 244022_at ------0.51 3.6E-03 7.7E-02 226213_at ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.51 3.6E-03 7.7E-02 220352_x_at FLJ42627 uncharacterized LOC645644 0.51 3.6E-03 7.7E-02 207323_s_at MBP basic protein 0.51 3.6E-03 7.7E-02 241416_at ------0.51 3.6E-03 7.7E-02 pancreatic progenitor cell differentiation and proliferation factor homolog 227994_x_at PPDPF 0.51 3.6E-03 7.7E-02 (zebrafish) 220212_s_at THADA thyroid adenoma associated 0.51 3.6E-03 7.7E-02 203629_s_at COG5 component of oligomeric golgi complex 5 0.51 3.5E-03 7.7E-02

15 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 213344_s_at H2AFX H2A histone family, member X 0.51 3.5E-03 7.7E-02 218507_at HILPDA hypoxia inducible lipid droplet-associated 0.51 3.5E-03 7.7E-02 217713_x_at ------0.51 3.5E-03 7.7E-02 232597_x_at SCAF11 SR-related CTD-associated factor 11 0.51 3.5E-03 7.7E-02 236621_at RPS27 ribosomal protein S27 0.51 3.4E-03 7.6E-02 242405_at ------0.51 3.4E-03 7.6E-02 238722_x_at NAPEPLD N-acyl phosphatidylethanolamine D 0.51 3.4E-03 7.6E-02 229498_at MBNL3 muscleblind-like splicing regulator 3 0.51 3.3E-03 7.5E-02 1568986_x_at PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.51 3.3E-03 7.5E-02 1554945_x_at VIL1 villin 1 0.51 3.3E-03 7.5E-02 233399_x_at ZNF252P zinc finger protein 252, pseudogene 0.51 3.3E-03 7.5E-02 239862_at ------0.51 3.3E-03 7.5E-02 206734_at JRKL jerky homolog-like (mouse) 0.51 3.3E-03 7.5E-02 204327_s_at ZNF202 zinc finger protein 202 0.51 3.3E-03 7.5E-02 229648_at ARHGAP32 Rho GTPase activating protein 32 0.51 3.3E-03 7.5E-02 203652_at MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.51 3.3E-03 7.5E-02 232579_at JHDM1D-AS1 uncharacterized LOC100134229 0.51 3.2E-03 7.5E-02 1559495_at ------0.51 3.2E-03 7.5E-02 237330_at ------0.51 3.2E-03 7.5E-02 232174_at ------0.51 3.2E-03 7.5E-02 77508_r_at RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.51 3.2E-03 7.5E-02 224569_s_at IRF2BP2 interferon regulatory factor 2 binding protein 2 0.51 3.1E-03 7.4E-02 238473_at LOC100216545 uncharacterized LOC100216545 0.51 3.1E-03 7.4E-02 236566_at ------0.51 3.1E-03 7.4E-02 209425_at AMACR alpha-methylacyl-CoA racemase 0.51 3.1E-03 7.4E-02 214924_s_at TRAK1 trafficking protein, kinesin binding 1 0.51 3.0E-03 7.3E-02 226635_at LOC100506710 endogenous Bornavirus-like 2 pseudogene 0.52 3.0E-03 7.3E-02 243078_at ------0.52 3.0E-03 7.2E-02 1555145_at CCSAP centriole, cilia and spindle-associated protein 0.52 3.0E-03 7.2E-02 222316_at ------0.52 3.0E-03 7.2E-02 242511_at ------0.52 3.0E-03 7.2E-02 238806_at ------0.52 2.9E-03 7.2E-02 229490_s_at ------0.52 2.9E-03 7.1E-02 240113_at ------0.52 2.9E-03 7.1E-02 1560596_at ------0.52 2.8E-03 7.1E-02 228292_at ------0.52 2.8E-03 7.1E-02 218414_s_at NDE1 nudE nuclear distribution E homolog 1 (A. nidulans) 0.52 2.8E-03 7.1E-02 229842_at ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.52 2.8E-03 7.1E-02 220491_at HAMP hepcidin antimicrobial 0.52 2.8E-03 7.1E-02 213642_at ------0.52 2.8E-03 7.1E-02 243981_at STK4 serine/threonine kinase 4 0.52 2.8E-03 7.1E-02 212599_at AUTS2 autism susceptibility candidate 2 0.52 2.8E-03 7.0E-02

211883_x_at CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.52 2.8E-03 7.0E-02

234321_x_at NHSL1 NHS-like 1 0.52 2.7E-03 7.0E-02 214076_at GFOD2 glucose- domain containing 2 0.52 2.7E-03 7.0E-02 242175_at ------0.52 2.7E-03 7.0E-02 234594_at ITPK1-AS1 ITPK1 antisense RNA 1 0.52 2.7E-03 6.9E-02 235242_at OTTHUMG00000179927 NULL 0.52 2.7E-03 6.9E-02 204275_at CAPN15 small optic lobes homolog (Drosophila) 0.52 2.6E-03 6.9E-02 227931_at INO80D INO80 complex subunit D 0.52 2.6E-03 6.9E-02 1556442_x_at ------0.52 2.6E-03 6.9E-02 208082_x_at MKRN4P NULL 0.52 2.6E-03 6.9E-02 219398_at CIDEC cell death-inducing DFFA-like effector c 0.52 2.6E-03 6.9E-02 235623_at ELP2 elongator acetyltransferase complex subunit 2 0.52 2.6E-03 6.9E-02 214114_x_at FASTK Fas-activated serine/threonine kinase 0.52 2.6E-03 6.9E-02 209426_s_at AMACR alpha-methylacyl-CoA racemase 0.52 2.6E-03 6.9E-02 243030_at ------0.52 2.6E-03 6.9E-02 217969_at VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 0.52 2.6E-03 6.9E-02 216094_at ------0.52 2.5E-03 6.9E-02 238967_at ------0.52 2.5E-03 6.9E-02 224284_x_at FKSG49 FKSG49 0.52 2.5E-03 6.9E-02 222647_at SLC35C1 solute carrier family 35, member C1 0.52 2.5E-03 6.8E-02 221754_s_at CORO1B coronin, actin binding protein, 1B 0.52 2.4E-03 6.8E-02 203618_at FAIM2 Fas apoptotic inhibitory molecule 2 0.52 2.4E-03 6.8E-02 202890_at MAP7 microtubule-associated protein 7 0.52 2.4E-03 6.8E-02 234159_at ------0.53 2.4E-03 6.8E-02 210827_s_at ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.53 2.4E-03 6.7E-02 232322_x_at STARD10 StAR-related lipid transfer (START) domain containing 10 0.53 2.4E-03 6.7E-02 1570269_at OTTHUMG00000176276 NULL 0.53 2.4E-03 6.7E-02 213600_at SIPA1L3 signal-induced proliferation-associated 1 like 3 0.53 2.3E-03 6.7E-02 207684_at TBX6 T-box 6 0.53 2.3E-03 6.7E-02 203442_x_at EML3 echinoderm microtubule associated protein like 3 0.53 2.2E-03 6.6E-02 242652_at ------0.53 2.2E-03 6.6E-02 212443_at NBEAL2 neurobeachin-like 2 0.53 2.2E-03 6.6E-02 242506_at ------0.53 2.2E-03 6.6E-02 239001_at MGST1 microsomal glutathione S-transferase 1 0.53 2.2E-03 6.6E-02 242126_at ------0.53 2.2E-03 6.6E-02 240114_s_at TMEM174 transmembrane protein 174 0.53 2.2E-03 6.5E-02 52741_at TRMT61A tRNA methyltransferase 61 homolog A (S. cerevisiae) 0.53 2.2E-03 6.5E-02 213813_x_at ------0.53 2.1E-03 6.5E-02 241837_at ------0.53 2.1E-03 6.5E-02 213572_s_at SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.53 2.1E-03 6.5E-02 203255_at FBXO11 F-box protein 11 0.53 2.1E-03 6.5E-02 232645_at LOC153684 uncharacterized LOC153684 0.53 2.1E-03 6.5E-02 239633_at ------0.53 2.1E-03 6.5E-02 243751_at CHD2 chromodomain helicase DNA binding protein 2 0.53 2.1E-03 6.5E-02 236627_at ------0.53 2.1E-03 6.5E-02 230505_at LOC145474 uncharacterized LOC145474 0.53 2.0E-03 6.4E-02 208022_s_at CDC14B cell division cycle 14B 0.53 2.0E-03 6.4E-02 220912_at ------0.53 2.0E-03 6.4E-02 1565567_at ------0.53 1.9E-03 6.4E-02 51192_at SSH3 slingshot protein phosphatase 3 0.53 1.9E-03 6.4E-02

16 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 221555_x_at CDC14B cell division cycle 14B 0.54 1.9E-03 6.4E-02 206936_x_at ------0.54 1.9E-03 6.4E-02 201510_at ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.54 1.9E-03 6.4E-02 228549_at OTTHUMG00000041221 NULL 0.54 1.9E-03 6.4E-02 1558822_at ------0.54 1.9E-03 6.4E-02 230914_at HNF4A hepatocyte nuclear factor 4, alpha 0.54 1.9E-03 6.4E-02 230361_at HEATR7A HEAT repeat-containing protein 7A-like 0.54 1.9E-03 6.4E-02 222284_at ------0.54 1.9E-03 6.4E-02 238715_at LOC646014 uncharacterized LOC646014 0.54 1.9E-03 6.4E-02 232342_at MTMR14 myotubularin related protein 14 0.54 1.9E-03 6.4E-02 1570166_a_at ------0.54 1.9E-03 6.4E-02 242151_at ------0.54 1.8E-03 6.3E-02 221799_at CHPF2 chondroitin polymerizing factor 2 0.54 1.8E-03 6.3E-02 242966_x_at RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.54 1.8E-03 6.3E-02 215006_at ------0.54 1.8E-03 6.3E-02 242858_at ------0.54 1.8E-03 6.2E-02 232012_at CAPN1 calpain 1, (mu/I) large subunit 0.54 1.7E-03 6.2E-02 232144_at ------0.54 1.7E-03 6.2E-02 241893_at ------0.54 1.7E-03 6.2E-02 217117_x_at MUC3A 3A, cell surface associated 0.54 1.7E-03 6.2E-02 235138_at ------0.54 1.7E-03 6.2E-02 226072_at FUK fucokinase 0.54 1.7E-03 6.2E-02 203287_at LAD1 ladinin 1 0.54 1.7E-03 6.1E-02 215588_x_at RIOK3 RIO kinase 3 0.54 1.7E-03 6.1E-02 217293_at ------0.54 1.7E-03 6.1E-02 229909_at B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.54 1.6E-03 6.1E-02 1559436_x_at ------0.54 1.6E-03 6.1E-02 1569601_at ------0.54 1.6E-03 6.1E-02 217133_x_at CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.54 1.6E-03 6.1E-02 213229_at DICER1 dicer 1, ribonuclease type III 0.54 1.6E-03 6.1E-02 214070_s_at ATP10B ATPase, class V, type 10B 0.54 1.6E-03 6.1E-02 233964_at ------0.54 1.6E-03 6.1E-02 205166_at CAPN5 calpain 5 0.54 1.5E-03 6.1E-02 226490_at NHSL1 NHS-like 1 0.54 1.5E-03 6.0E-02 204352_at TRAF5 TNF receptor-associated factor 5 0.54 1.5E-03 6.0E-02 242040_at GCNT7 glucosaminyl (N-acetyl) transferase family member 7 0.55 1.5E-03 6.0E-02 227098_at DUSP18 dual specificity phosphatase 18 0.55 1.5E-03 6.0E-02 37831_at SIPA1L3 signal-induced proliferation-associated 1 like 3 0.55 1.5E-03 6.0E-02 203394_s_at HES1 hairy and enhancer of split 1, (Drosophila) 0.55 1.5E-03 6.0E-02 1556232_at KIF6 kinesin family member 6 0.55 1.5E-03 6.0E-02 1554095_at RBM33 RNA binding motif protein 33 0.55 1.5E-03 6.0E-02 226231_at PAWR PRKC, apoptosis, WT1, regulator 0.55 1.4E-03 5.9E-02 219041_s_at REPIN1 replication initiator 1 0.55 1.4E-03 5.9E-02 232500_at RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.55 1.4E-03 5.8E-02 223725_at LINC00852 long intergenic non-protein coding RNA 852 0.55 1.4E-03 5.8E-02 1556352_at ------0.55 1.4E-03 5.8E-02 204112_s_at HNMT histamine N-methyltransferase 0.55 1.3E-03 5.8E-02 227738_s_at ARMC5 armadillo repeat containing 5 0.55 1.3E-03 5.8E-02 234490_at ------0.55 1.3E-03 5.8E-02 1560689_s_at AKT2 v-akt murine thymoma viral oncogene homolog 2 0.55 1.3E-03 5.8E-02 208238_x_at ------0.55 1.3E-03 5.8E-02 222266_at ------0.55 1.3E-03 5.8E-02 205986_at AATK apoptosis-associated 0.55 1.3E-03 5.7E-02 242874_at OTTHUMG00000172989 NULL 0.55 1.3E-03 5.7E-02 215208_x_at RPL35A ribosomal protein L35a 0.55 1.3E-03 5.7E-02 232179_at LOC158863 uncharacterized LOC158863 0.55 1.3E-03 5.7E-02 240385_at ------0.55 1.3E-03 5.7E-02 214055_x_at PRRC2C proline-rich coiled-coil 2C 0.55 1.3E-03 5.7E-02 212884_x_at APOE apolipoprotein E 0.55 1.2E-03 5.7E-02 240367_at OTTHUMG00000173191 NULL 0.55 1.2E-03 5.7E-02 244181_at ------0.55 1.2E-03 5.7E-02 202970_at DYRK2 dual-specificity tyrosine-(Y)- regulated kinase 2 0.55 1.2E-03 5.6E-02 1557158_s_at KMT2C lysine (K)-specific methyltransferase 2C 0.55 1.2E-03 5.6E-02 215583_at TMEM63A transmembrane protein 63A 0.56 1.2E-03 5.5E-02 239532_at ------0.56 1.2E-03 5.4E-02 202117_at ARHGAP1 Rho GTPase activating protein 1 0.56 1.1E-03 5.4E-02 239660_at RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.56 1.1E-03 5.3E-02 206048_at OVOL2 ovo-like 2 (Drosophila) 0.56 1.1E-03 5.3E-02 1564498_at ------0.56 1.1E-03 5.3E-02 244059_at ------0.56 1.1E-03 5.3E-02 204579_at FGFR4 fibroblast growth factor receptor 4 0.56 1.1E-03 5.2E-02 229420_at LOC101243545 uncharacterized LOC101243545 0.56 1.0E-03 5.2E-02 242803_at ------0.56 1.0E-03 5.2E-02 1561502_x_at CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 0.56 9.8E-04 5.1E-02 1554039_at C14orf159 chromosome 14 open reading frame 159 0.56 9.6E-04 5.1E-02 213486_at COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding) 0.56 9.6E-04 5.1E-02 1487_at ESRRA estrogen-related receptor alpha 0.56 9.5E-04 5.1E-02 228726_at SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.56 9.5E-04 5.1E-02 213879_at ------0.56 9.3E-04 5.0E-02 206257_at CCDC9 coiled-coil domain containing 9 0.57 9.2E-04 5.0E-02 234946_at ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.57 9.0E-04 5.0E-02 215398_at ------0.57 8.9E-04 5.0E-02 222733_x_at RRP1 ribosomal RNA processing 1 homolog (S. cerevisiae) 0.57 8.9E-04 5.0E-02 206010_at HABP2 hyaluronan binding protein 2 0.57 8.9E-04 5.0E-02 242735_x_at ELF2 E74-like factor 2 (ets domain transcription factor) 0.57 8.8E-04 5.0E-02 203431_s_at ARHGAP32 Rho GTPase activating protein 32 0.57 8.7E-04 5.0E-02 215032_at RREB1 ras responsive element binding protein 1 0.57 8.4E-04 4.8E-02 218661_at NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.57 8.1E-04 4.8E-02 222641_s_at FAM222B family with sequence similarity 222, member B 0.57 8.0E-04 4.8E-02 1559078_at LOC100506934 uncharacterized LOC100506934 0.57 7.8E-04 4.7E-02 214861_at KDM4C lysine (K)-specific demethylase 4C 0.57 7.7E-04 4.7E-02 235788_at HCG18 HLA complex group 18 (non-protein coding) 0.57 7.4E-04 4.6E-02 203569_s_at OFD1 oral-facial-digital syndrome 1 0.57 7.4E-04 4.6E-02

17 of 18 Supplementary Table 2

probeSets ID Gene Symbol Gene Name Spearman's Rho Spearman's p val BH (FDR) adjusted p-value 230212_at SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.57 7.4E-04 4.6E-02 240061_at ------0.57 7.2E-04 4.6E-02 1566231_at ------0.58 6.9E-04 4.5E-02 60528_at JMJD7 jumonji domain containing 7 0.58 6.9E-04 4.5E-02 solute carrier family 3 (cystine, dibasic and neutral transporters, 205799_s_at SLC3A1 0.58 6.7E-04 4.5E-02 activator of cystine, dibasic and neutral amino acid transport), member 1

237494_at OTTHUMG00000172651 NULL 0.58 6.6E-04 4.4E-02 240263_at ------0.58 6.6E-04 4.4E-02 216263_s_at NGDN neuroguidin, EIF4E binding protein 0.58 6.4E-04 4.4E-02 242445_at FGD4 FYVE, RhoGEF and PH domain containing 4 0.58 6.4E-04 4.4E-02 211693_at IGH immunoglobulin heavy locus 0.58 6.3E-04 4.4E-02 218965_s_at TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 0.58 6.3E-04 4.4E-02 226295_at ITFG2 integrin alpha FG-GAP repeat containing 2 0.58 6.2E-04 4.3E-02 225258_at FBLIM1 binding LIM protein 1 0.58 5.9E-04 4.3E-02 232530_at PLD1 , phosphatidylcholine-specific 0.58 5.8E-04 4.3E-02 1564129_a_at ------0.58 5.7E-04 4.3E-02 1565881_at CTD-2233K9.1 NULL 0.58 5.7E-04 4.3E-02 233027_at ------0.58 5.6E-04 4.3E-02 1564753_at ------0.59 5.3E-04 4.2E-02 202700_s_at TMEM63A transmembrane protein 63A 0.59 5.3E-04 4.2E-02 64486_at CORO1B coronin, actin binding protein, 1B 0.59 5.3E-04 4.2E-02 209873_s_at PKP3 3 0.59 5.3E-04 4.2E-02 211252_x_at PTCRA pre T-cell antigen receptor alpha 0.59 5.1E-04 4.1E-02 214001_x_at RPS10 ribosomal protein S10 0.59 5.1E-04 4.1E-02 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross 211657_at CEACAM6 0.59 4.9E-04 4.1E-02 reacting antigen) 1566577_at ------0.59 4.7E-04 4.0E-02 241785_at ------0.59 4.6E-04 4.0E-02 219241_x_at SSH3 slingshot protein phosphatase 3 0.59 4.6E-04 4.0E-02 217573_at GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.59 4.5E-04 4.0E-02 237310_at ------0.59 4.2E-04 3.9E-02 214041_x_at RPL37A ribosomal protein L37a 0.59 4.2E-04 3.9E-02 235145_at ZBTB7B zinc finger and BTB domain containing 7B 0.60 4.1E-04 3.9E-02 232022_at OTTHUMG00000015879 NULL 0.60 3.8E-04 3.7E-02 45526_g_at NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.60 3.8E-04 3.7E-02 206323_x_at OPHN1 oligophrenin 1 0.60 3.8E-04 3.7E-02 232619_at ACTL10 actin-like 10 0.60 3.7E-04 3.7E-02 221656_s_at ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.60 3.5E-04 3.7E-02 200861_at CNOT1 CCR4-NOT transcription complex, subunit 1 0.60 3.4E-04 3.7E-02 213743_at CCNT2 cyclin T2 0.60 3.1E-04 3.5E-02 1556656_at ------0.60 3.1E-04 3.5E-02 239227_at ------0.61 3.0E-04 3.5E-02 239600_at ------0.61 3.0E-04 3.5E-02 215887_at ZNF277 zinc finger protein 277 0.61 2.8E-04 3.4E-02 227429_at EFCAB4A EF-hand calcium binding domain 4A 0.61 2.7E-04 3.4E-02 1556584_at ------0.61 2.7E-04 3.4E-02 61874_at CACFD1 calcium channel flower domain containing 1 0.61 2.6E-04 3.3E-02 222352_at FBXO31 F-box protein 31 0.61 2.6E-04 3.3E-02 244086_at ------0.61 2.6E-04 3.3E-02 218960_at TMPRSS4 transmembrane , serine 4 0.61 2.4E-04 3.3E-02 216635_at ------0.61 2.4E-04 3.3E-02 236332_at DHRS7 dehydrogenase/reductase (SDR family) member 7 0.62 2.2E-04 3.2E-02 223044_at SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.62 2.1E-04 3.2E-02 241797_at ------0.62 2.0E-04 3.1E-02 1556030_at OTTHUMG00000151204 NULL 0.62 1.8E-04 2.9E-02 238422_at LBX2-AS1 LBX2 antisense RNA 1 0.62 1.8E-04 2.9E-02 224858_at ZDHHC5 zinc finger, DHHC-type containing 5 0.62 1.8E-04 2.9E-02 221648_s_at AGMAT agmatine () 0.62 1.7E-04 2.9E-02 202709_at FMOD 0.63 1.6E-04 2.9E-02 221610_s_at STAP2 signal transducing adaptor family member 2 0.63 1.6E-04 2.9E-02 237176_at ------0.63 1.5E-04 2.9E-02 230772_at HNF4A hepatocyte nuclear factor 4, alpha 0.63 1.5E-04 2.9E-02 201425_at ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.63 1.4E-04 2.9E-02 65635_at ENGASE endo-beta-N-acetylglucosaminidase 0.63 1.4E-04 2.9E-02 219919_s_at SSH3 slingshot protein phosphatase 3 0.63 1.4E-04 2.9E-02 1570511_at ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.63 1.4E-04 2.9E-02 236239_at XPNPEP1 X- (aminopeptidase P) 1, soluble 0.63 1.4E-04 2.9E-02 220975_s_at C1QTNF1 C1q and related protein 1 0.63 1.3E-04 2.9E-02 241520_x_at ------0.63 1.3E-04 2.9E-02 222370_x_at ------0.63 1.3E-04 2.9E-02 1552752_a_at CADM2 cell adhesion molecule 2 0.64 1.2E-04 2.9E-02 1562861_at ------0.64 1.2E-04 2.9E-02 220371_s_at SLC12A9 solute carrier family 12 (potassium/chloride transporters), member 9 0.64 1.0E-04 2.9E-02 201884_at CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.64 1.0E-04 2.8E-02 210264_at GPR35 G protein-coupled receptor 35 0.64 9.8E-05 2.8E-02 201369_s_at ZFP36L2 ZFP36 ring finger protein-like 2 0.64 9.2E-05 2.8E-02 220465_at CEBPA-AS1 CEBPA antisense RNA 1 (head to head) 0.65 8.6E-05 2.7E-02 229690_at FAM109A family with sequence similarity 109, member A 0.65 6.8E-05 2.6E-02 200070_at CNPPD1 cyclin Pas1/PHO80 domain containing 1 0.65 6.6E-05 2.6E-02 203201_at PMM2 phosphomannomutase 2 0.65 6.5E-05 2.6E-02 201368_at ZFP36L2 ZFP36 ring finger protein-like 2 0.66 6.1E-05 2.6E-02 1569679_at CDH22 cadherin 22, type 2 0.66 5.9E-05 2.6E-02 dolichyl-phosphate (UDP-N-acetylglucosamine) N- 209509_s_at DPAGT1 0.66 4.9E-05 2.5E-02 acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 239588_s_at ------0.68 3.1E-05 2.1E-02 208987_s_at KDM2A lysine (K)-specific demethylase 2A 0.69 2.0E-05 1.7E-02 214316_x_at CTC-425F1.4 NULL 0.72 4.8E-06 1.2E-02

18 of 18 Supplementary Table 3

Supplementary Table 3: Functional group enrichment analysis using categories. Only significantly enriched categories are shown (Benjamini-Hochberg-corrected p<0.05)

Category: Gene Ontology categories: biological process (BP), cellular compartment (CC) and molecular function (MF). Term: Gene set name Count: number of genes associated with this gene set Percentag: gene associated with this gene set/total number of query genes P-value: modified Fisher Exact P-value List Total: number of genes in the query list mapped to any gene set in this ontology Pop Hits: number of genes annotated to this gene set on the background list Pop Total: number of genes on the background list mapped to any gene set in this ontology. Fold enrichment Benjamini: Benjamini-Hochberg-corrected p-value

Category Term Count % PValue List Total Pop Hits Pop Total Fold Enrichment Benjamini GOTERM_BP_ALL GO:0044260~cellular macromolecule metabolic process 525 40.7 2.0E-29 972 5214 14116 1.46 6.1E-26 GOTERM_BP_ALL GO:0044237~cellular metabolic process 622 48.2 1.6E-28 972 6636 14116 1.36 2.4E-25 GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 543 42.1 5.1E-24 972 5710 14116 1.38 3.9E-21 GOTERM_BP_ALL GO:0009987~cellular process 849 65.8 4.2E-24 972 10541 14116 1.17 4.3E-21 GOTERM_BP_ALL GO:0008152~metabolic process 660 51.2 7.5E-20 972 7647 14116 1.25 4.6E-17 GOTERM_BP_ALL GO:0044238~primary metabolic process 610 47.3 2.2E-19 972 6923 14116 1.28 1.1E-16 GOTERM_BP_ALL GO:0044267~cellular protein metabolic process 259 20.1 4.4E-16 972 2355 14116 1.60 1.9E-13 GOTERM_BP_ALL GO:0007049~cell cycle 116 9.0 1.2E-15 972 776 14116 2.17 4.6E-13 GOTERM_BP_ALL GO:0000278~mitotic cell cycle 70 5.4 1.6E-14 972 370 14116 2.75 5.3E-12 GOTERM_BP_ALL GO:0016070~RNA metabolic process 129 10.0 1.8E-14 972 938 14116 2.00 5.4E-12 GOTERM_BP_ALL GO:0008380~RNA splicing 59 4.6 3.7E-14 972 284 14116 3.02 1.0E-11 GOTERM_BP_ALL GO:0016071~mRNA metabolic process 69 5.3 5.2E-14 972 370 14116 2.71 1.3E-11 GOTERM_BP_ALL GO:0006397~mRNA processing 63 4.9 6.9E-14 972 321 14116 2.85 1.6E-11 GO:0006139~nucleobase, nucleoside, nucleotide and GOTERM_BP_ALL 330 25.6 8.7E-13 972 3409 14116 1.41 1.9E-10 nucleic acid metabolic process GOTERM_BP_ALL GO:0006996~organelle organization 160 12.4 1.1E-12 972 1332 14116 1.74 2.1E-10 GOTERM_BP_ALL GO:0000087~M phase of mitotic cell cycle 48 3.7 3.7E-12 972 224 14116 3.11 7.1E-10 GOTERM_BP_ALL GO:0016043~cellular component organization 255 19.8 5.6E-12 972 2498 14116 1.48 1.0E-09 GOTERM_BP_ALL GO:0022402~cell cycle process 85 6.6 1.0E-11 972 565 14116 2.18 1.5E-09 GO:0000377~RNA splicing, via transesterification GOTERM_BP_ALL 38 2.9 9.4E-12 972 153 14116 3.61 1.6E-09 reactions with bulged adenosine as nucleophile GOTERM_BP_ALL GO:0000398~nuclear mRNA splicing, via spliceosome 38 2.9 9.4E-12 972 153 14116 3.61 1.6E-09 GO:0000375~RNA splicing, via transesterification GOTERM_BP_ALL 38 2.9 9.4E-12 972 153 14116 3.61 1.6E-09 reactions GO:0034641~cellular nitrogen compound metabolic GOTERM_BP_ALL 345 26.7 1.0E-11 972 3670 14116 1.37 1.6E-09 process GOTERM_BP_ALL GO:0006396~RNA processing 83 6.4 1.2E-11 972 547 14116 2.20 1.7E-09 GOTERM_BP_ALL GO:0044265~cellular macromolecule catabolic process 100 7.8 2.2E-11 972 725 14116 2.00 3.0E-09 GOTERM_BP_ALL GO:0019538~protein metabolic process 276 21.4 4.5E-11 972 2812 14116 1.43 5.9E-09 GO:0019941~modification-dependent protein catabolic GOTERM_BP_ALL 84 6.5 5.8E-11 972 574 14116 2.13 7.4E-09 process GO:0043632~modification-dependent macromolecule GOTERM_BP_ALL 84 6.5 5.8E-11 972 574 14116 2.13 7.4E-09 catabolic process GOTERM_BP_ALL GO:0022403~cell cycle phase 67 5.2 9.3E-11 972 414 14116 2.35 1.1E-08 GOTERM_BP_ALL GO:0000280~nuclear division 45 3.5 9.7E-11 972 220 14116 2.97 1.1E-08 GOTERM_BP_ALL GO:0007067~mitosis 45 3.5 9.7E-11 972 220 14116 2.97 1.1E-08

1 of 5 Supplementary Table 3

Category Term Count % PValue List Total Pop Hits Pop Total Fold Enrichment Benjamini GOTERM_BP_ALL GO:0030163~protein catabolic process 88 6.8 1.1E-10 972 622 14116 2.05 1.3E-08 GOTERM_BP_ALL GO:0044257~cellular protein catabolic process 86 6.7 1.3E-10 972 603 14116 2.07 1.4E-08 GOTERM_BP_ALL GO:0006807~nitrogen compound metabolic process 347 26.9 2.0E-10 972 3778 14116 1.33 2.0E-08 GOTERM_BP_ALL GO:0000279~M phase 57 4.4 2.1E-10 972 329 14116 2.52 2.1E-08 GO:0051603~ involved in cellular protein GOTERM_BP_ALL 85 6.6 2.3E-10 972 600 14116 2.06 2.3E-08 catabolic process GOTERM_BP_ALL GO:0009057~macromolecule catabolic process 102 7.9 3.1E-10 972 781 14116 1.90 3.0E-08 GOTERM_BP_ALL GO:0048285~organelle fission 45 3.5 3.8E-10 972 229 14116 2.85 3.5E-08 GO:0006511~ubiquitin-dependent protein catabolic GOTERM_BP_ALL 46 3.6 7.2E-10 972 242 14116 2.76 6.4E-08 process GOTERM_BP_ALL GO:0051301~cell division 52 4.0 7.7E-10 972 295 14116 2.56 6.7E-08 GOTERM_BP_ALL GO:0010467~ 284 22.0 1.1E-09 972 2999 14116 1.38 9.1E-08 GOTERM_BP_ALL GO:0006259~DNA metabolic process 73 5.7 2.4E-09 972 506 14116 2.10 2.0E-07 GO:0043933~macromolecular complex subunit GOTERM_BP_ALL 91 7.1 8.4E-09 972 710 14116 1.86 6.8E-07 organization GOTERM_BP_ALL GO:0044248~cellular catabolic process 118 9.1 2.1E-08 972 1024 14116 1.67 1.6E-06 GOTERM_BP_ALL GO:0044085~cellular component biogenesis 115 8.9 3.8E-08 972 1001 14116 1.67 2.9E-06 GOTERM_BP_ALL GO:0065003~macromolecular complex assembly 84 6.5 6.7E-08 972 665 14116 1.83 5.0E-06 GOTERM_BP_ALL GO:0022607~cellular component assembly 103 8.0 1.3E-07 972 887 14116 1.69 9.6E-06 GOTERM_BP_ALL GO:0033554~cellular response to stress 73 5.7 2.5E-07 972 566 14116 1.87 1.7E-05 GOTERM_BP_ALL GO:0009056~catabolic process 133 10.3 3.0E-07 972 1253 14116 1.54 2.1E-05 GOTERM_BP_ALL GO:0006974~response to DNA damage stimulus 54 4.2 3.3E-07 972 373 14116 2.10 2.2E-05 GOTERM_BP_ALL GO:0051276~chromosome organization 64 5.0 6.9E-07 972 485 14116 1.92 4.6E-05 GO:0034645~cellular macromolecule biosynthetic GOTERM_BP_ALL 253 19.6 1.3E-06 972 2812 14116 1.31 8.7E-05 process GOTERM_BP_ALL GO:0009059~macromolecule biosynthetic process 253 19.6 2.3E-06 972 2832 14116 1.30 1.5E-04 GOTERM_BP_ALL GO:0000075~cell cycle checkpoint 21 1.6 2.8E-06 972 91 14116 3.35 1.7E-04 GOTERM_BP_ALL GO:0007346~regulation of mitotic cell cycle 28 2.2 4.5E-06 972 152 14116 2.68 2.7E-04 GOTERM_BP_ALL GO:0046907~intracellular transport 77 6.0 4.6E-06 972 657 14116 1.70 2.8E-04 GO:0034621~cellular macromolecular complex subunit GOTERM_BP_ALL 49 3.8 5.8E-06 972 357 14116 1.99 3.3E-04 organization GOTERM_BP_ALL GO:0006260~DNA replication 32 2.5 5.8E-06 972 190 14116 2.45 3.4E-04 GOTERM_BP_ALL GO:0044249~cellular biosynthetic process 296 22.9 6.1E-06 972 3442 14116 1.25 3.4E-04 GOTERM_BP_ALL GO:0051340~regulation of ligase activity 19 1.5 7.4E-06 972 81 14116 3.41 4.1E-04 GOTERM_BP_ALL GO:0006412~translation 46 3.6 8.5E-06 972 331 14116 2.02 4.6E-04 GO:0060255~regulation of macromolecule metabolic GOTERM_BP_ALL 281 21.8 1.0E-05 972 3259 14116 1.25 5.4E-04 process GOTERM_BP_ALL GO:0006281~DNA repair 41 3.2 1.1E-05 972 284 14116 2.10 6.0E-04 GOTERM_BP_ALL GO:0051716~cellular response to stimulus 89 6.9 1.7E-05 972 820 14116 1.58 8.5E-04 GO:0043161~proteasomal ubiquitin-dependent protein GOTERM_BP_ALL 21 1.6 1.7E-05 972 102 14116 2.99 8.7E-04 catabolic process GOTERM_BP_ALL GO:0010498~proteasomal protein catabolic process 21 1.6 1.7E-05 972 102 14116 2.99 8.7E-04 GOTERM_BP_ALL GO:0051726~regulation of cell cycle 45 3.5 1.9E-05 972 331 14116 1.97 9.3E-04 GOTERM_BP_ALL GO:0080090~regulation of primary metabolic process 279 21.6 4.2E-05 972 3291 14116 1.23 2.0E-03 GOTERM_BP_ALL GO:0070271~protein complex biogenesis 60 4.7 4.1E-05 972 505 14116 1.73 2.0E-03 GOTERM_BP_ALL GO:0006461~protein complex assembly 60 4.7 4.1E-05 972 505 14116 1.73 2.0E-03 GOTERM_BP_ALL GO:0009058~biosynthetic process 297 23.0 4.7E-05 972 3542 14116 1.22 2.3E-03 GOTERM_BP_ALL GO:0022618~ribonucleoprotein complex assembly 16 1.2 5.5E-05 972 69 14116 3.37 2.6E-03 GO:0051438~regulation of ubiquitin-protein ligase GOTERM_BP_ALL 17 1.3 6.7E-05 972 78 14116 3.17 3.1E-03 activity GO:0051439~regulation of ubiquitin-protein ligase GOTERM_BP_ALL 16 1.2 7.8E-05 972 71 14116 3.27 3.5E-03 activity during mitotic cell cycle

2 of 5 Supplementary Table 3

Category Term Count % PValue List Total Pop Hits Pop Total Fold Enrichment Benjamini GOTERM_BP_ALL GO:0043412~biopolymer modification 143 11.1 8.3E-05 972 1526 14116 1.36 3.7E-03 GOTERM_BP_ALL GO:0015031~protein transport 81 6.3 8.6E-05 972 762 14116 1.54 3.8E-03 GOTERM_BP_ALL GO:0006310~DNA recombination 20 1.6 8.8E-05 972 105 14116 2.77 3.8E-03 GOTERM_BP_ALL GO:0022613~ribonucleoprotein complex biogenesis 28 2.2 1.0E-04 972 180 14116 2.26 4.3E-03 GOTERM_BP_ALL GO:0051246~regulation of protein metabolic process 62 4.8 1.1E-04 972 546 14116 1.65 4.6E-03 GOTERM_BP_ALL GO:0043687~post-translational protein modification 115 8.9 1.1E-04 972 1182 14116 1.41 4.6E-03 GOTERM_BP_ALL GO:0051351~positive regulation of ligase activity 16 1.2 1.1E-04 972 73 14116 3.18 4.6E-03 GOTERM_BP_ALL GO:0045184~establishment of protein localization 81 6.3 1.2E-04 972 769 14116 1.53 4.6E-03 GOTERM_BP_ALL GO:0007093~mitotic cell cycle checkpoint 12 0.9 1.1E-04 972 43 14116 4.05 4.7E-03 GOTERM_BP_ALL GO:0007017~microtubule-based process 35 2.7 1.3E-04 972 253 14116 2.01 5.2E-03 GOTERM_BP_ALL GO:0006464~protein modification process 136 10.5 1.3E-04 972 1453 14116 1.36 5.2E-03 GOTERM_BP_ALL GO:0019222~regulation of metabolic process 299 23.2 1.4E-04 972 3621 14116 1.20 5.4E-03 GO:0034622~cellular macromolecular complex GOTERM_BP_ALL 41 3.2 1.5E-04 972 318 14116 1.87 5.7E-03 assembly GOTERM_BP_ALL GO:0051649~establishment of localization in cell 87 6.7 1.8E-04 972 852 14116 1.48 6.7E-03 GOTERM_BP_ALL GO:0033043~regulation of organelle organization 31 2.4 1.9E-04 972 217 14116 2.07 7.2E-03 GO:0010605~negative regulation of macromolecule GOTERM_BP_ALL 77 6.0 2.0E-04 972 734 14116 1.52 7.3E-03 metabolic process GOTERM_BP_ALL GO:0006325~chromatin organization 46 3.6 2.2E-04 972 378 14116 1.77 8.0E-03 GOTERM_BP_ALL GO:0016568~chromatin modification 36 2.8 2.8E-04 972 274 14116 1.91 1.0E-02 GO:0032268~regulation of cellular protein metabolic GOTERM_BP_ALL 54 4.2 3.1E-04 972 474 14116 1.65 1.1E-02 process GOTERM_BP_ALL GO:0051641~cellular localization 92 7.1 3.2E-04 972 928 14116 1.44 1.1E-02 GOTERM_BP_ALL GO:0006508~proteolysis 102 7.9 3.5E-04 972 1054 14116 1.41 1.2E-02 GOTERM_BP_ALL GO:0031323~regulation of cellular metabolic process 284 22.0 3.9E-04 972 3464 14116 1.19 1.3E-02 GO:0031145~anaphase-promoting complex-dependent GOTERM_BP_ALL proteasomal ubiquitin-dependent protein catabolic 14 1.1 4.1E-04 972 65 14116 3.13 1.4E-02 process GOTERM_BP_ALL GO:0000226~microtubule organization 23 1.8 4.5E-04 972 147 14116 2.27 1.5E-02 GOTERM_BP_ALL GO:0009892~negative regulation of metabolic process 79 6.1 4.8E-04 972 780 14116 1.47 1.6E-02 GOTERM_BP_ALL GO:0006261~DNA-dependent DNA replication 13 1.0 4.9E-04 972 58 14116 3.26 1.6E-02 GOTERM_BP_ALL GO:0006414~translational elongation 18 1.4 4.9E-04 972 101 14116 2.59 1.6E-02 GOTERM_BP_ALL GO:0009411~response to UV 13 1.0 5.8E-04 972 59 14116 3.20 1.8E-02 GOTERM_BP_ALL GO:0051329~interphase of mitotic cell cycle 18 1.4 6.2E-04 972 103 14116 2.54 2.0E-02 GO:0051437~positive regulation of ubiquitin-protein GOTERM_BP_ALL 14 1.1 6.5E-04 972 68 14116 2.99 2.0E-02 ligase activity during mitotic cell cycle GOTERM_BP_ALL GO:0031570~DNA integrity checkpoint 12 0.9 6.8E-04 972 52 14116 3.35 2.1E-02 GO:0051443~positive regulation of ubiquitin-protein GOTERM_BP_ALL 14 1.1 8.6E-04 972 70 14116 2.90 2.6E-02 ligase activity GOTERM_BP_ALL GO:0051325~interphase 18 1.4 8.7E-04 972 106 14116 2.47 2.6E-02 GOTERM_BP_ALL GO:0031396~regulation of protein ubiquitination 17 1.3 1.3E-03 972 100 14116 2.47 3.7E-02 GO:0010608~posttranscriptional regulation of gene GOTERM_BP_ALL 28 2.2 1.3E-03 972 211 14116 1.93 3.8E-02 expression GOTERM_BP_ALL GO:0007088~regulation of mitosis 12 0.9 1.3E-03 972 56 14116 3.11 3.8E-02 GOTERM_BP_ALL GO:0051783~regulation of nuclear division 12 0.9 1.3E-03 972 56 14116 3.11 3.8E-02 GOTERM_BP_ALL GO:0000077~DNA damage checkpoint 11 0.9 1.3E-03 972 48 14116 3.33 3.9E-02 GOTERM_BP_ALL GO:0016044~membrane organization 43 3.3 1.6E-03 972 381 14116 1.64 4.6E-02 GOTERM_BP_ALL GO:0080135~regulation of cellular response to stress 17 1.3 1.7E-03 972 103 14116 2.40 4.8E-02 GOTERM_CC_ALL GO:0005622~intracellular 939 72.8 5.7E-63 1041 10995 15908 1.31 3.2E-60 GOTERM_CC_ALL GO:0044424~intracellular part 921 71.4 1.2E-62 1041 10624 15908 1.32 3.3E-60 GOTERM_CC_ALL GO:0043229~intracellular organelle 790 61.2 1.1E-41 1041 8977 15908 1.34 2.0E-39

3 of 5 Supplementary Table 3

Category Term Count % PValue List Total Pop Hits Pop Total Fold Enrichment Benjamini GOTERM_CC_ALL GO:0043226~organelle 790 61.2 2.1E-41 1041 8989 15908 1.34 3.0E-39 GOTERM_CC_ALL GO:0043227~membrane-bounded organelle 715 55.4 6.7E-36 1041 7989 15908 1.37 7.5E-34 GOTERM_CC_ALL GO:0043231~intracellular membrane-bounded organelle 714 55.3 1.1E-35 1041 7982 15908 1.37 9.9E-34 GOTERM_CC_ALL GO:0044446~intracellular organelle part 454 35.2 6.9E-35 1041 4225 15908 1.64 4.9E-33 GOTERM_CC_ALL GO:0044422~organelle part 456 35.3 6.7E-35 1041 4251 15908 1.64 5.4E-33 GOTERM_CC_ALL GO:0044428~nuclear part 251 19.5 1.2E-32 1041 1822 15908 2.11 7.3E-31 GOTERM_CC_ALL GO:0005634~nucleus 504 39.1 1.3E-30 1041 5077 15908 1.52 7.4E-29 GOTERM_CC_ALL GO:0005737~cytoplasm 651 50.5 8.9E-29 1041 7319 15908 1.36 4.5E-27 GOTERM_CC_ALL GO:0070013~intracellular organelle lumen 231 17.9 4.5E-26 1041 1779 15908 1.98 2.1E-24 GOTERM_CC_ALL GO:0031981~nuclear lumen 200 15.5 1.4E-25 1041 1450 15908 2.11 6.0E-24 GOTERM_CC_ALL GO:0031974~membrane-enclosed lumen 235 18.2 5.3E-25 1041 1856 15908 1.93 2.1E-23 GOTERM_CC_ALL GO:0043233~organelle lumen 231 17.9 1.1E-24 1041 1820 15908 1.94 4.1E-23 GOTERM_CC_ALL GO:0032991~macromolecular complex 332 25.7 8.2E-22 1041 3155 15908 1.61 2.9E-20 GOTERM_CC_ALL GO:0043228~non-membrane-bounded organelle 285 22.1 5.9E-21 1041 2596 15908 1.68 2.0E-19 GO:0043232~intracellular non-membrane-bounded GOTERM_CC_ALL 285 22.1 5.9E-21 1041 2596 15908 1.68 2.0E-19 organelle GOTERM_CC_ALL GO:0005654~nucleoplasm 132 10.2 1.0E-19 1041 882 15908 2.29 3.2E-18 GOTERM_CC_ALL GO:0005829~ 164 12.7 7.5E-16 1041 1330 15908 1.88 2.3E-14 GOTERM_CC_ALL GO:0005623~cell 1024 79.4 1.0E-15 1041 14827 15908 1.06 2.7E-14 GOTERM_CC_ALL GO:0044464~cell part 1024 79.4 1.0E-15 1041 14826 15908 1.06 2.8E-14 GOTERM_CC_ALL GO:0030529~ribonucleoprotein complex 83 6.4 3.4E-14 1041 515 15908 2.46 8.7E-13 GOTERM_CC_ALL GO:0044444~cytoplasmic part 431 33.4 5.5E-14 1041 4895 15908 1.35 1.4E-12 GOTERM_CC_ALL GO:0043234~protein complex 252 19.5 8.9E-12 1041 2588 15908 1.49 2.1E-10 GOTERM_CC_ALL GO:0044451~nucleoplasm part 78 6.0 2.2E-10 1041 555 15908 2.15 5.0E-09 GOTERM_CC_ALL GO:0005694~chromosome 66 5.1 2.9E-09 1041 460 15908 2.19 6.2E-08 GOTERM_CC_ALL GO:0005681~spliceosome 30 2.3 5.7E-09 1041 132 15908 3.47 1.2E-07 GOTERM_CC_ALL GO:0005730~nucleolus 86 6.7 1.6E-08 1041 698 15908 1.88 3.2E-07 GOTERM_CC_ALL GO:0044427~chromosomal part 56 4.3 3.6E-08 1041 386 15908 2.22 7.0E-07 GOTERM_CC_ALL GO:0015630~microtubule cytoskeleton 71 5.5 5.1E-08 1041 549 15908 1.98 9.6E-07 GOTERM_CC_ALL GO:0016607~nuclear speck 23 1.8 6.5E-07 1041 103 15908 3.41 1.2E-05 GOTERM_CC_ALL GO:0005819~spindle 28 2.2 9.0E-07 1041 147 15908 2.91 1.6E-05 GOTERM_CC_ALL GO:0016604~nuclear body 30 2.3 1.4E-06 1041 168 15908 2.73 2.3E-05 GOTERM_CC_ALL GO:0031967~organelle envelope 72 5.6 2.5E-06 1041 620 15908 1.77 4.1E-05 GOTERM_CC_ALL GO:0031975~envelope 72 5.6 2.8E-06 1041 622 15908 1.77 4.5E-05 GOTERM_CC_ALL GO:0005739~ 110 8.5 3.8E-06 1041 1087 15908 1.55 5.9E-05 GOTERM_CC_ALL GO:0005813~centrosome 33 2.6 2.4E-05 1041 224 15908 2.25 3.7E-04 GOTERM_CC_ALL GO:0048471~perinuclear region of cytoplasm 39 3.0 2.8E-05 1041 288 15908 2.07 4.1E-04 GOTERM_CC_ALL GO:0005643~nuclear pore 17 1.3 4.3E-05 1041 79 15908 3.29 6.2E-04 GOTERM_CC_ALL GO:0005815~microtubule organizing center 35 2.7 5.0E-05 1041 253 15908 2.11 7.0E-04 GOTERM_CC_ALL GO:0005856~cytoskeleton 126 9.8 9.3E-05 1041 1381 15908 1.39 1.3E-03 GOTERM_CC_ALL GO:0005840~ribosome 30 2.3 1.6E-04 1041 215 15908 2.13 2.2E-03 GOTERM_CC_ALL GO:0044429~mitochondrial part 62 4.8 3.1E-04 1041 595 15908 1.59 4.0E-03 GOTERM_CC_ALL GO:0046930~pore complex 17 1.3 4.1E-04 1041 95 15908 2.73 5.2E-03 GOTERM_CC_ALL GO:0019866~organelle inner membrane 39 3.0 4.5E-04 1041 329 15908 1.81 5.5E-03 GOTERM_CC_ALL GO:0005743~mitochondrial inner membrane 37 2.9 4.5E-04 1041 306 15908 1.85 5.6E-03 GO:0030530~heterogeneous nuclear ribonucleoprotein GOTERM_CC_ALL 7 0.5 5.1E-04 1041 17 15908 6.29 5.9E-03 complex GOTERM_CC_ALL GO:0005874~microtubule 34 2.6 5.0E-04 1041 274 15908 1.90 6.0E-03 GOTERM_CC_ALL GO:0030027~lamellipodium 14 1.1 5.4E-04 1041 70 15908 3.06 6.1E-03 GOTERM_CC_ALL GO:0031252~cell leading edge 21 1.6 6.4E-04 1041 138 15908 2.33 7.2E-03 GOTERM_CC_ALL GO:0031966~mitochondrial membrane 44 3.4 6.6E-04 1041 394 15908 1.71 7.3E-03

4 of 5 Supplementary Table 3

Category Term Count % PValue List Total Pop Hits Pop Total Fold Enrichment Benjamini GOTERM_CC_ALL GO:0031090~organelle membrane 99 7.7 8.4E-04 1041 1096 15908 1.38 8.9E-03 GOTERM_CC_ALL GO:0005657~replication fork 9 0.7 8.3E-04 1041 32 15908 4.30 9.0E-03 GOTERM_CC_ALL GO:0000228~nuclear chromosome 23 1.8 8.7E-04 1041 162 15908 2.17 9.0E-03 GOTERM_CC_ALL GO:0005635~nuclear envelope 27 2.1 8.9E-04 1041 205 15908 2.01 9.1E-03 GOTERM_CC_ALL GO:0044454~nuclear chromosome part 19 1.5 9.5E-04 1041 122 15908 2.38 9.5E-03 GOTERM_CC_ALL GO:0000922~spindle 9 0.7 1.3E-03 1041 34 15908 4.05 1.2E-02 GOTERM_CC_ALL GO:0005740~mitochondrial envelope 45 3.5 1.3E-03 1041 419 15908 1.64 1.2E-02 GOTERM_CC_ALL GO:0033279~ribosomal subunit 19 1.5 1.7E-03 1041 128 15908 2.27 1.6E-02 GOTERM_CC_ALL GO:0044430~cytoskeletal part 86 6.7 1.9E-03 1041 952 15908 1.38 1.8E-02 GOTERM_CC_ALL GO:0005876~spindle microtubule 8 0.6 2.2E-03 1041 29 15908 4.22 2.0E-02 GOTERM_CC_ALL GO:0044445~cytosolic part 21 1.6 2.2E-03 1041 152 15908 2.11 2.0E-02 GOTERM_CC_ALL GO:0012505~endomembrane system 72 5.6 2.9E-03 1041 782 15908 1.41 2.5E-02 GOTERM_CC_ALL GO:0000775~chromosome, centromeric region 18 1.4 2.9E-03 1041 124 15908 2.22 2.5E-02 GOTERM_CC_ALL GO:0000785~chromatin 25 1.9 2.9E-03 1041 200 15908 1.91 2.6E-02 GOTERM_CC_ALL GO:0005663~DNA replication factor C complex 4 0.3 4.8E-03 1041 6 15908 10.19 4.0E-02 GOTERM_MF_ALL GO:0005515~protein binding 703 54.5 1.1E-19 1049 8154 15143 1.24 1.1E-16 GOTERM_MF_ALL GO:0000166~nucleotide binding 238 18.4 2.2E-12 1049 2245 15143 1.53 1.1E-09 GOTERM_MF_ALL GO:0003723~RNA binding 101 7.8 8.3E-12 1049 718 15143 2.03 2.7E-09 GOTERM_MF_ALL GO:0005488~binding 939 72.8 1.5E-10 1049 12531 15143 1.08 3.8E-08 GOTERM_MF_ALL GO:0003676~nucleic acid binding 302 23.4 8.6E-09 1049 3264 15143 1.34 1.7E-06 GOTERM_MF_ALL GO:0017076~purine nucleotide binding 190 14.7 1.5E-07 1049 1918 15143 1.43 2.4E-05 GOTERM_MF_ALL GO:0032553~ribonucleotide binding 183 14.2 1.8E-07 1049 1836 15143 1.44 2.5E-05 GOTERM_MF_ALL GO:0032555~purine ribonucleotide binding 183 14.2 1.8E-07 1049 1836 15143 1.44 2.5E-05 GOTERM_MF_ALL GO:0003824~catalytic activity 434 33.6 6.1E-07 1049 5198 15143 1.21 7.5E-05 GOTERM_MF_ALL GO:0001883~purine nucleoside binding 159 12.3 1.8E-06 1049 1601 15143 1.43 1.8E-04 GOTERM_MF_ALL GO:0017111~nucleoside-triphosphatase activity 85 6.6 2.1E-06 1049 728 15143 1.69 1.8E-04 GOTERM_MF_ALL GO:0001882~nucleoside binding 160 12.4 1.7E-06 1049 1612 15143 1.43 1.9E-04 GOTERM_MF_ALL GO:0005524~ATP binding 148 11.5 2.7E-06 1049 1477 15143 1.45 2.2E-04 GOTERM_MF_ALL GO:0032559~adenyl ribonucleotide binding 149 11.6 3.6E-06 1049 1497 15143 1.44 2.7E-04 GOTERM_MF_ALL GO:0030554~adenyl nucleotide binding 155 12.0 4.5E-06 1049 1577 15143 1.42 3.2E-04 GOTERM_MF_ALL GO:0016462~pyrophosphatase activity 86 6.7 5.3E-06 1049 757 15143 1.64 3.5E-04 GO:0016818~hydrolase activity, acting on acid GOTERM_MF_ALL 86 6.7 6.3E-06 1049 760 15143 1.63 3.9E-04 anhydrides, in phosphorus-containing anhydrides GO:0016817~hydrolase activity, acting on acid GOTERM_MF_ALL 86 6.7 7.7E-06 1049 764 15143 1.62 4.4E-04 anhydrides GOTERM_MF_ALL GO:0003712~transcription cofactor activity 49 3.8 1.1E-05 1049 363 15143 1.95 5.9E-04 GOTERM_MF_ALL GO:0008094~DNA-dependent ATPase activity 15 1.2 2.5E-05 1049 57 15143 3.80 1.3E-03 GOTERM_MF_ALL GO:0051082~unfolded protein binding 22 1.7 3.6E-05 1049 115 15143 2.76 1.8E-03 GOTERM_MF_ALL GO:0008134~transcription factor binding 61 4.7 4.1E-05 1049 513 15143 1.72 1.9E-03 GO:0016879~ligase activity, forming carbon-nitrogen GOTERM_MF_ALL 34 2.6 5.6E-05 1049 231 15143 2.12 2.5E-03 bonds GOTERM_MF_ALL GO:0016881~acid-amino acid ligase activity 30 2.3 1.3E-04 1049 201 15143 2.15 5.5E-03 GOTERM_MF_ALL GO:0004386~helicase activity 23 1.8 2.4E-04 1049 140 15143 2.37 9.9E-03 GOTERM_MF_ALL GO:0016874~ligase activity 46 3.6 4.9E-04 1049 390 15143 1.70 1.8E-02 GOTERM_MF_ALL GO:0016887~ATPase activity 41 3.2 4.7E-04 1049 334 15143 1.77 1.8E-02 GOTERM_MF_ALL GO:0003735~structural constituent of ribosome 25 1.9 5.5E-04 1049 168 15143 2.15 2.0E-02 GOTERM_MF_ALL GO:0008234~cysteine-type peptidase activity 22 1.7 6.9E-04 1049 141 15143 2.25 2.4E-02 GO:0031202~RNA splicing factor activity, GOTERM_MF_ALL 8 0.6 9.1E-04 1049 24 15143 4.81 3.0E-02 transesterification mechanism GOTERM_MF_ALL GO:0019787~small conjugating protein ligase activity 24 1.9 1.1E-03 1049 166 15143 2.09 3.5E-02 GOTERM_MF_ALL GO:0042623~ATPase activity, coupled 34 2.6 1.1E-03 1049 272 15143 1.80 3.6E-02 GOTERM_MF_ALL GO:0004523~ activity 5 0.4 1.3E-03 1049 8 15143 9.02 3.8E-02

5 of 5 Supplementary Table 4: Associations between PPOX or GAPDH levels and clinicopathological features of a cohort of 433 colorectal tumors from the TCGA.

PPOX GAPDH

Gender&'Mean±SD&(n) p&value p&value &&Male 7.54±0.03((196) 0.771 16.05±0.04((196) 0.411 &&Female 7.55±0.03((228) 16.10±0.04((228)

Site&'Mean±SD&(n) 1 1 &&Colon 7.51±0.03((320) 0.64 16.13±0.03((320) 0.22 &&Rectum 7.48±0.05((101) 15.93±0.05((101)

Venous&invasion&'Mean±SD&(n) &&No 16.09±0.03((284) 0.461 7.49±0.03((284) 0.691 &&Yes 15.99±0.06((81) 7.51±0.05((81)

Pathologic&T&'Mean±SD&(n) &&T1 16.09±0.16((12) 0.682 7.65±0.11((12) 0.242 &&T2 16.04±0.07((66) 7.42±0.07((66) &&T3 16.06±0.03((66) 7.50±0.28((66) &&T4 16.12±0.07((53) 7.58±0.07(53)

Pathologic&N&'Mean±SD&(n) 2 2 &&N0 16.13±0.04((237) 0.08 7.47±0.03((237) 0.26 &&N1 16.05±0.05((106) 7.54±0.05((106) &&N2 15.97±0.06((76) 7.56±0.05((76)

Pathologic&M&'Mean±SD&(n) &&M0 16.12±0.03((285) 0.381 7.50±0.03((285) 0.861 &&M1 15.90±0.07((58) 7.54±0.06((58)

Tumor&stage 2 2 &&I 16.10±0.07((65) 0.04 7.44±0.06((65) 0.48 &&II 16.16±0.05((157) 7.48±0.04((157) &&III 16.02±0.05((125) 7.54±0.04((125) &&IV 15.92±0.07((62) 7.53±0.06((62)

Tumor&size&'pearson's&r&(n) 0.00((424) 0.933 0.04((424) 0.353

Age&'pearson's&r&(n) 0.02((293) 0.673 00.01((293) 0.823

1Student's T-test; 2ANOVA; 3Pearson's correlation