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Biomédica 2017;37:460-5 Girón-Callejas A, Mendizábal-Burastero R, Yax E, et al. Biomédica 2017;37:460-5 460 Portada: Laboratorio de Higiene Samper-Martínez Fotografía publicada en el Informe elaborado por Pablo García Medina, vicepresidente de la Junta Central de Higiene. Casa editorial de Arboleda y Valencia, 1919 Cortesía de Carlos Fernando Dáguer, asesor, Ministerio de Salud y Protección Social Biomédica Instituto Nacional de Salud Volumen 37, No. 4 - Bogotá, D.C., Colombia - Diciembre de 2017 Comité Editorial EDITOR E S LUIS AL B ERTO GÓMEZ CA RLOS ARTURO HERNÁNDEZ RU B ÉN SA NTI A GO NI ch OLLS Instituto Nacional de Salud Instituto Nacional de Salud Organización Panamericana de la Salud Bogotá, D.C., Colombia Bogotá, D.C., Colombia Washington, D.C., Estados Unidos EDITOR E S ASOCI A DOS ENRIQUE ARDIL A LEON A RD MUNSTERM A NN Bogotá, D.C., Colombia Yale University School of Medicine New Haven, CT, Estados Unidos JOSÉ DE JESÚS MORENO -MONTOY A Universidad El Bosque OM A R SEGUR A Bogotá, D.C., Colombia Federación Médica Colombiana Bogotá, D.C., Colombia JULIÁN AL F REDO FERNÁNDEZ -NIÑO Universidad del Norte ORL A NDO TORRES -FERNÁNDEZ Barranquilla, Colombia Instituto Nacional de Salud Bogotá, D.C., Colombia MIGUEL A. GUZMÁN Investigador Emérito RA ÚL PA RDO Instituto Nacional de Salud Instituto Nacional de Salud Bogotá, D.C., Colombia Bogotá, D.C., Colombia Comité Científico ARNOLDO BA R B OS A ANDRÉS DE FR A N C IS C O JO H N MA RIO GONZÁLEZ Universidad del Tolima Organización Mundial de la Salud Universidad de los Andes Ibagué, Colombia Ginebra, Suiza Bogotá, D.C., Colombia ANTONIO BERMÚDEZ FERN A NDO DE L A HOZ FELI P E GU H L Instituto Nacional de Salud Universidad Nacional de Colombia Universidad de los Andes Bogotá, D.C., Colombia Bogotá, D.C., Colombia Bogotá, D.C., Colombia JORGE H. BOTERO JOSÉ LUIS DI Fab IO ANTONIO IGLESI A S Universidad de Antioquia Organización Panamericana de la Salud Universidad Nacional de Colombia Medellín, Colombia Washington, D.C., Estados Unidos Bogotá, D.C., Colombia JORGE HERN A NDO DON A DO GUST A VO ALONSO Cab RER A JORGE JA R A Universidad de Antioquia Universidad Pontificia Bolivariana Centers for Disease Control and Medellín, Colombia Medellín, Colombia Prevention, Regional Office for Central America and Panama, CA RLOS ANDRÉS FA NDIÑO VÍ C TOR CÁRDEN A S Universidad del Valle CDC-CAP University of Texas Cali, Colombia Ciudad de Guatemala, Guatemala El Paso, TX, Estados Unidos JOSÉ FIGUERO A ERNESTO JA R A MILLO AL B ERTO CON cha -EA STM A N World Health Organization Organización Mundial de la Salud Guatapé, Colombia Ginebra, Suiza Ginebra, Suiza OILO UÉLL A R Z C LUIS FERN A NDO GA R C Í A MA R C ELO Lab RUN A Academia Nacional de Medicina Universidad de Antioquia Universidade de São Paulo Bogotá, D.C., Colombia Medellín, Colombia São Paulo, Brasil LUIS Gab RIEL CUERVO AL B ERTO GÓMEZ JA IRO LIZ A R A ZO Organización Panamericana Pontificia Universidad Javeriana Hospital Universitario Erasmo Meoz de la Salud Bogotá, D.C., Colombia Cúcuta, Colombia Washington, D.C., Estados Unidos ENRIQUE GONZÁLEZ JU A N GUILLERMO MCEWEN PA TRI C I A DEL PORTILLO University of Texas Health Science Center Corporación para Investigaciones Corpogén at San Antonio Biológicas Bogotá, D.C., Colombia San Antonio, TX, Estados Unidos Medellín, Colombia 437 RO B ERTO MENDOZ A VÍ C TOR E. REYES NA N C Y GORE SA R A VI A The Hospital for Sick Children University of Texas Medical Branch Centro Internacional de Entrenamiento Toronto, Ontario, Canada Galveston, TX, Estados Unidos e Investigaciones Médicas Cali, Colombia ÁLV A RO MON ca YO GUST A VO C. ROMÁN Universidad de los Andes Methodist Neurological Institute RO B ERT TES H Bogotá, D.C., Colombia Houston, TX, Estados Unidos University of Texas EDRO OMERO GA LVESTON , TX, EST A DOS UNIDOS RI ca RDO NEGRONI P R Ludwig Center for Cancer Research Hospital de Infecciosas BRUNO TR A VI Francisco Javier Muñiz University of Lausanne University of Texas Buenos Aires, Argentina Lausana, Suiza Galveston, TX, Estados Unidos ÁLV A RO RUIZ MA RÍ A TERES A Och O A GUST A VO VA L B UEN A Pontificia Universidad Javeriana University of California Los Ángeles University of Texas Bogotá, D.C., Colombia Los Ángeles, CA, Estados Unidos Galveston, TX, Estados Unidos GIO C OND A SA N BL A S JU A N P. OL A NO Instituto Venezolano de JU A N MIGUEL VILL A LO B OS University of Texas Medical Branch Investigaciones Científicas Universidade Federal de Rondônia Galveston, TX, Estados Unidos Caracas, Venezuela Porto Velho, Brasil BL A N ca RESTRE P O ÁLV A RO SA N ab RI A MOISÉS WA SSERM A N University of Texas Hospital Pablo Tobón Uribe Investigador Emérito Brownsville, TX, Estados Unidos Medellín, Colombia Instituto Nacional de Salud Universidad de la Sabana Universidad Nacional de Colombia GERZ A ÍN RODRÍGUEZ Chía, Colombia Bogotá, D.C., Colombia Investigador Emérito Instituto Nacional de Salud RI ca RDO SÁN ch EZ Universidad de la Sabana Universidad Nacional de Colombia Bogotá, D.C., Colombia Bogotá, D.C., Colombia CA RLOS ARTURO HERNÁNDEZ LIND A GR ac E MOL A NO MA RT ha RENZ A ELIZ ab ET H GUZMÁN JO ha NN A MOR A LES Edición y corrección de estilo Asistencia editorial Corrección de estilo Mercadeo digital Diagramación © Instituto Nacional de Salud La revista Biomédica del Instituto Nacional de Salud es una publicación trimestral, eminentemente científica. Está amparada por la resolución número 003768 de 1981, emanada del Ministerio de Gobierno, y con tarifa postal reducida según resolución número 1128 del 5 de mayo de 1982. Ninguna publicación, nacional o extranjera, podrá reproducir ni traducir sus artículos ni sus resúmenes sin previa autorización escrita del editor. Ni la revista, ni el Instituto asumen responsabilidad alguna por los puntos de vista expresados por los autores. La revista no publicará ningún tipo de propaganda comercial. Los nombres de equipos, materiales y productos manufacturados que eventualmente puedan mencionarse, no implican recomendación ni propaganda para su uso y sólo se mencionan como identificación genérica. La revista Biomédica aparece reseñada en Index Medicus/Medline de la National Library of Medicine, en el Science Citation Index Expanded (also known as SciSearch®) y Journal Citation Reports/Science Edition de Thomson Scientific, en SciELO Colombia (Scientific Electronic Library Online), en el índice de la Literatura Latinoamericana en Ciencias de la Salud (LILACS), en la Red de Revistas Científicas de América Latina, el Caribe, España y Portugal (RedAlyC), en el Índice Mexicano de Revistas Biomédicas Latinoamericanas (Imbiomed), en Scopus de Elsevier B.V., en el Sistema de Información Bibliográfica Regional Andina (SIBRA), en CAB Abstracts, Review of Medical and Veterinary Entomology, y forma parte del Índice Nacional de Publicaciones Seriadas Científicas y Tecnológicas Colombianas de Colciencias y del Índice Latinoamericano de Revistas Científicas y Tecnológicas (LATINDEX). INSTITUTO NACIONAL DE SALUD Avenida Calle 26 No. 51-20 Apartado aéreo 80334 y 80080 Bogotá, D.C., Colombia, S.A. URL: http://www.ins.gov.co [email protected] 438 Contenido Editorial Estimación del subregistro de casos de enfermedad Un siglo del Instituto Nacional de Salud y una por el virus del chikungunya en Girardot, Colombia, proyección para los próximos años noviembre de 2014 a mayo de 2015 Martha Lucía Ospina Martínez ........................................... 441 Óscar Pacheco, Máncel Martínez, Ángela Alarcón, Mauricio Bonilla, Alexandra Caycedo, Tania Valbuena, Presentación de caso Angie Zabaleta .................................................................... 507 Presentación del síndrome de Wernicke-Korsakoff Microbiota periodontal y microorganismos aislados de secundario a encefalitis por citomegalovirus, válvulas cardiacas en pacientes sometidos a cirugía de a propósito de un caso reemplazo de válvulas en una clínica de Cali, Colombia Luis Guillermo Uribe, María Alejandra Pérez, Sandra Moreno, Beatriz Parra, Javier E. Botero, Freddy Camilo Andrés Lara, Natalia Rueda, Moreno, Daniel Vásquez, Hugo Fernández, Sandra Alba, Javier Augusto Hernández ................................................. 444 Sara Gallego, Gilberto Castillo, Adolfo Contreras .............. 516 Artículo original Cómo intervenir y prevenir el retraso del crecimiento Sensibilidad in vitro de cepas cubanas de en niños menores de cinco años de hogares incluidos Aspergillus spp. de origen clínico y ambiental en el Sisbén de Caldas Javier L. San Juan, Carlos M. Fernández, María Victoria Benjumea, José Hernán Parra, Michel Almaguer, Mayda R. Perurena, Juan Felipe Jaramillo .......................................................... 526 Gerardo F. Martínez, Rosario E. Velar, Curvas de fusión de regiones genómicas específicas: María T. Illnait ..................................................................... 452 una herramienta prometedora para el diagnóstico Optimización de recursos para determinar la y tipificación de las especies causantes de la carga viral de HIV-1 en un país con pocos recursos leishmaniasis cutánea en Colombia Amalia Girón-Callejas, Ricardo Mendizábal-Burastero, Johana Marín, Daniel Urrea, Carlos Muskus, María Clara Elizabeth Yax, Axel Martínez, Carlos Mejía-Villatoro ........... 460 Echeverry, Ana María Mejía, Omar Triana ......................... 538 Características de la infección por Clostridium Diversidad del ADN mitocondrial en restos óseos difficile en una institución de alta complejidad y prehispánicos asociados al Templo del Sol en los reporte de la circulación en Colombia de la
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