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Outcomes-Quality / Basic Medical Sciences / Therapeutic Effectiveness / Case Reports Morning Session (9:00am-12:00m) Outcomes-Quality / Basic Medical Sciences / Therapeutic Effectiveness / Case Reports Outcomes/Quality Poster # Presenting Author Title Y1A James Davies A Prospective Multicenter Evaluation of the Value of the On-Call Orthopaedic Resident Y2A Heather Staples Increasing Access to Physical Therapy in Hospitalized CF Patients: A Quality Improvement Study Y3A Nithya M. Natrajan The Effect of Patient and Physician Education on Colorectal Cancer Screening Rates Y4A Felicea Patel Referral Processes in an Outpatient Clinical Setting: A QI Project Y5A Kelli Savia Transitional Readiness in Adolescents with Sickle Cell Disease: A Quality Improvement Project Y6A Chloe McCoy Evaluation of a short-term training program in bedside emergency ultrasound in Southwestern Tanzania Y7A Ashley Guthrie Aligning organizational and resident team discharge goals: Process Interventions for Physicians on Accountable Care Units Y8A Justin Puthoff Predictability of Pulmonary Fellowship Board Score Outcomes Through the Use of Concurrent In-Service Interventional Training and Examinations Y9A Justin Quinn Physician Perceptions of an Accountable Care Unit Model Implementation in an Inpatient Setting Y10A Satya Potluri Integration of Continuous Glucose Monitoring with Insulin Pump Technology to Manage Diabetes Leads to Improved Outcomes Y11A Donna Wolff Mobility on an ACE Unit: Reducing Length of Stay by Increasing Ambulation Y12A Allison Shannon Improving Recognition and Response to Obstetric Hemorrhage: Implementation of an OB Hemorrhage Protocol at Palmetto Health Y13A Forest Weir Audiologic Outcomes in Duane's Retraction Syndrome Y14A Alexandra Moreira Isolated lower extremity fractures in the elderly, is there an increased morbidity and mortality? A single center retrospective review at a level one trauma center. Y15A Victoria Hagen Understanding of Diabetes Care Among Frail Elders/Caregivers Y16A Kristen Nathe Open ankle fractures in the elderly: A multi-center study Y17A Teresa Garrison GeriJoy Versus Usual Care for ACTT Patients: A Pilot Study Y18A Caitlin Lozorak Evaluation of an evidence-based acute hematogenous osteomyelitis treatment protocol Y19A Kristin Bell Retrospective Review of Prophylactic Bilateral Salpingectomy at Palmetto Health Richland: Evaluation of Rates and Perioperative Complications Y20A Christopher Chu Trends in the management of pelvic fractures, 2008-2010 Y21A Jeevan Abraham The High Prevalence of Obesity and Cardiovascular Risk Factors in Patients with Type 1 Diabetes seen in an Academic Endocrinology Practice Y22A Sarah Lewter Initiation of a Treatment Switch from a Multiple-Tablet Antiretroviral Regimen to a Single-Tablet Antiretroviral Regimen in A Non-Adherent HIV Population Y23A Julian Duda Causes and Predictors of Mortality in a Large U.S. Myotonic Dystrophy Type 1 Adult Cohort Y24A Scott Holt Bedside Rounding Checklist to Reduce Device-Related Harm Y25A Fran Bailey Attitudes and Practice Patterns Regarding Trial of Labor after Cesarean Delivery Basic Medical Sciences B1A Taryn Cranford Role of Monocyte Chemoattractant Protein-1 on Inflammatory Processes and Metabolic Dysfunction Following High-Fat Feedings in the FVB/N Strain B2A Allison Manuel Protein Succination Promotes Endoplasmic Reticulum Stress in the Adipocyte During Diabetes B3A Richard Kordus Human Cumulus Cells of Oocytes Giving Rise to Embryos Capable of Forming a Viable Pregnancy Exhibit Specific mRNA Differences B4A Ashley Galloway Morphogenic Effects of Dopamine in Primary Cultured Rat Astrocytes B5A Eric Ritchardson Antibodies for neutralization of chemokine (C-C motif) ligand 8 (CCL8) activity B6A Gerardo Piroli Succination is increased on select proteins in the brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 knockout mouse B7A Desiree Leach The Role of Cyclin Dependent Kinase 8 in Vascular Stem Cell-Mediated Vascular Remodeling Therapeutic Effectiveness/Efficiency G1A Rachel Foster Tenofovir plasma concentrations in obese, Human Immunodeficiency Virus-infected subjects G2A Marwa Belhaj Enhancements in Alginate Microcapsules and Impacts on Cell Encapsulation G3A Amit Choudhari Dietary agent withaferin-A regulates monocyte derived inflammatory cytokines via suppression of IL-1beta G4A Alex Hall The Effect of Garlic in Reducing Inflammation in Dengue Infection G5A Henrik Berdel The use of a degradable biomaterial to regulate fibrosis at the implant-host interface G6A Leila Kutob Effectiveness of Oral Antimicrobial Agents for Definitive Therapy of Gram-Negative Bloodstream Infections G7A Charmaine Jenkins The Effectiveness of Sphenopalatine Ganglion Blockade on Different Headache Disorders: An Ongoing, Open- Label Prospective Outcome Study G8A Sarah Tryon Muscarinic Modulation of Glutamatergic Input to the Basolateral Amygdala G9A Maria Hosseinipour SIX1 overexpression extends the lifespan, promotes epithelial-mesenchymal transition and results in decreased p53 levels in normal human keratinocytes G10A Jackie Bader Macrophage depletion decreases inflammation and tumorigenesis in the azoxymethane and dextran sulfate sodium mouse model of colon cancer Case Reports/Small Series/Learning Innovation R1A Judson Lewis A Swallowed Coin R2A Neil Patel A Rare Case of Sporadic CJD: A Case Report R3A William Melton A Comparison of Measurement Modalities for Concussion in Soccer R4A Cynthia Oliva A rare diagnosis: CJD R5A Brett Bentley Door-to-Door in Sébaco: Identifying the Health Care Needs of a Rural Nicaraguan Town R6A Michael Patterson Out of the Blue: A Case of Monocular Frosted Branch Angiitis In A Young Healthy Woman R7A Stephanie Galloway Unaffected Women's Decisions to Have Prophylactic Risk-Reducing Mastectomies R8A Samuel Scoma Just Another “UTI”? A Case of Renal Obstruction Diagnosed by Point-of-Care R9A Rachel Foster Oritavancin for the treatment of VRE osteomyelitis following total hip implant removal R10A Alfredo Arrojas Trends in the treatment of single and multi-level cervical stenosis: A review of the American Board of Orthopaedic surgery database R11A Lakesha Williams Bedside Ultrasonography to Diagnose Rib Fracture in the Outpatient Setting: A Case Report R12A Shefali Patel The Effectiveness of Manual Therapy and Postural Exercises in Suspected 1st Rib Dysfunction R13A Andy Swentik Revisiting a necessity: Dual plate stabilization of severely comminuted intra/supracondylar femur fractures R14A Douglas Davis (Dis)Connected At The Hip: A Case Of Piriformis Syndrome R15A Darien Davda What Lies Beneath: A Case Review for an Insidious Dieulafoy's Lesion R16A Joseph Milano Don’t lose your head over this rare knee injury: Isolated Fibular Head Dislocation R17A Michael Murphy Prevalence of Hypertension in Adolescent Athletes in South Carolina R18A Judson Lewis Pediatrics in the MICU R19A Natasha Rudy The Informational and Emotional Support Needs of Grandparents of Children with Pompe Disease R20A Rebecca Burnside Point-of-Care Hand-Held Ultrasound in the Ambulatory Setting to Evaluate Shortness of Breath and Chest Pain R21A Elizabeth Baker Bedside Diagnosis of Deep Vein Thrombosis Using Pocket-Sized Ultrasound R22A LaToya Lee Quantifying Sonogram Proficiency Development in Screening for Left Ventricular Hypertrophy R23A Johnie Hodge The Future is Bright for Biotech and Healthcare Research in South Carolina R24A Hayley Barbato Cardiac Tamponade as a Rare Presentation of Systemic Lupus Erythematosus in a Young Male Afternoon Session (1:00m-4:00pm) Outcomes-Quality / Basic Medical Sciences / Therapeutic Effectiveness / Case Reports Outcomes/Quality Poster # Presenting Author Title Y26B Callie Meeks The Impact of Centering PregnancyTM Group Prenatal Care on Patient Satisfaction Y27B Kyle Mobley An analysis of the efficacy of current clinical methods of determination of sterilization integrity Y28B Ashlee Justice Percutaneous Gastrostomy Tube Complications in a Tertiary Care Center: A Retrospective Study Y29B Rohan Mankikar An Unexpected Benefit: Does Early Urinary Catheter Removal Reduce The Risk of Surface Dependent Pressure Ulcers In The Critically Ill? Y30B Alexander Walters African American Triple Negative Breast Cancer Patients At Palmetto Health: A Comparison To National Data Y31B Maryann Mbaka The Use of Intraoperative Nerve Monitor During Thyroid and Parathyroid Related Surgeries and its Impact on the Rate of Nerve Injuries Y32B Thomas Ergen Criteria to Help Determine a Septic Joint Y33B Alexis Pilato The association between lumbar spine and hip pathology Y34B Steven Hermiz Isolated Spinal Cord Injury: The Need for Early Tracheostomy Y35B Kumaraswamy Chitrala Bioinformatics-based approach to analyze the gene expression profiles in post-traumatic stress disorder Y36B Derick Wenning Comparison of Procalcitonin to WBC count as a Screening Marker for Serious Bacterial Infection in Febrile Children less than 3 months of age Y37B Kyle Johnson Morphometric analysis of the developing pediatric cervical spine Y38B Cortney Dodson Accuracy of body weight obtainment in patients who receive alteplase in the emergency department for an acute ischemic stroke Y39B Marlon Rampaul Late HIV Diagnosis and Missed Opportunities for Early Testing in South Carolina Y40B Katie Dahlberg Administration Of Tissue Plasminogen Activator: To Wait Or Not To Wait For Screening Coagulation Tests? Impact on Door to Needle Time and Symptomatic lntracerebral Hemorrhage Y41B Emily Acker Impact of Penicillin Allergy on Empiric Carbapenem Therapy in Patients with Community-Onset Gram- Negative Bacteremia Y42B Hanna Shin Odds of viral suppression
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    Review J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.2008.158261 on 22 February 2010. Downloaded from The myotonic dystrophies: diagnosis and management Chris Turner,1 David Hilton-Jones2 1Department of Neurology, ABSTRACT asymptomatic relatives as well as prenatal and National Hospital for Neurology There are currently two clinically and molecularly defined preimplantation diagnosis can also be performed.7 and Neurosurgery, London, UK 2Department of Clinical forms of myotonic dystrophy: (1) myotonic dystrophy Neurology, The Radcliffe type 1 (DM1), also known as ‘Steinert’s disease’; and Anticipation Infirmary, Oxford, UK (2) myotonic dystrophy type 2 (DM2), also known as DMPK alleles greater than 37 CTG repeats in length proximal myotonic myopathy. DM1 and DM2 are are unstable and may expand in length during meiosis Correspondence to progressive multisystem genetic disorders with several and mitosis. Children of a parent with DM1 may Dr C Turner, Department of Neurology, National Hospital for clinical and genetic features in common. DM1 is the most inherit repeat lengths considerably longer than those Neurology and Neurosurgery, common form of adult onset muscular dystrophy whereas present in the transmitting parent. This phenomenon Queen Square, London WC1N DM2 tends to have a milder phenotype with later onset of causes ‘anticipation’, which is the occurrence of 3BG, UK; symptoms and is rarer than DM1. This review will focus increasing disease severity and decreasing age of onset [email protected] on the clinical features, diagnosis and management of in successive generations. The presence of a larger Received 1 December 2008 DM1 and DM2 and will briefly discuss the recent repeat leads to earlier onset and more severe disease Accepted 18 December 2008 advances in the understanding of the molecular and causes the more severe phenotype of ‘congenital’ pathogenesis of these diseases with particular reference DM1 (figure 2).8 9 A child with congenital DM 1 to new treatments using gene therapy.
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