Tree Scale: 10
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Conservation and Diversification of Small RNA Pathways Within Flatworms Santiago Fontenla1, Gabriel Rinaldi2, Pablo Smircich1,3 and Jose F
Fontenla et al. BMC Evolutionary Biology (2017) 17:215 DOI 10.1186/s12862-017-1061-5 RESEARCH ARTICLE Open Access Conservation and diversification of small RNA pathways within flatworms Santiago Fontenla1, Gabriel Rinaldi2, Pablo Smircich1,3 and Jose F. Tort1* Abstract Background: Small non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free-living and parasitic lineages of flatworms, but only few key factors of the small RNA pathways have been exhaustively investigated in a limited number of species. The availability of flatworm draft genomes and predicted proteomes allowed us to perform an extended survey of the genes involved in small non-coding RNA pathways in this phylum. Results: Overall, findings show that the small non-coding RNA pathways are conserved in all the analyzed flatworm linages; however notable peculiarities were identified. While Piwi genes are amplified in free-living worms they are completely absent in all parasitic species. Remarkably all flatworms share a specific Argonaute family (FL-Ago) that has been independently amplified in different lineages. Other key factors such as Dicer are also duplicated, with Dicer-2 showing structural differences between trematodes, cestodes and free-living flatworms. Similarly, a very divergent GW182 Argonaute interacting protein was identified in all flatworm linages. Contrasting to this, genes involved in the amplification of the RNAi interfering signal were detected only in the ancestral free living species Macrostomum lignano. We here described all the putative small RNA pathways present in both free living and parasitic flatworm lineages. Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms. -
TRBA 464 Biologische Arbeitsstoffe in Risikogruppen
Ausgabe Juli 2013 Technische Regeln für Einstufung von Parasiten TRBA 464 Biologische Arbeitsstoffe in Risikogruppen Die Technischen Regeln für Biologische Arbeitsstoffe (TRBA) geben den Stand der Technik, Arbeitsmedizin und Arbeitshygiene sowie sonstige gesicherte wissenschaftliche Erkenntnisse für Tätigkeiten mit biologischen Arbeitsstoffen, einschließlich deren Einstufung, wieder. Sie werden vom Ausschuss für Biologische Arbeitsstoffe ermittelt bzw. angepasst und vom Bundesministerium für Arbeit und Soziales im Gemeinsamen Ministerialblatt bekannt gegeben. Die TRBA „Einstufung von Parasiten in Risikogruppen“ konkretisiert im Rahmen des Anwendungsbereichs die Anforderungen der Biostoffverordnung. Bei Einhaltung der Technischen Regeln kann der Arbeitgeber insoweit davon ausgehen, dass die entsprechenden Anforderungen der Verordnung erfüllt sind. Die Einstufungen der biologischen Arbeitsstoffe in Risikogruppen werden nach dem Stand der Wissenschaft vorgenommen; der Arbeitgeber hat die Einstufung zu beachten. Die vorliegende Technische Regel schreibt die Technische Regel „Einstufung von Parasiten in Risikogruppen“ (Stand Oktober 2002) fort und wurde unter Federführung des Fachbereichs „Rohstoffe und chemische Industrie“ in Anwendung des Kooperationsmodells (vgl. Leitlinienpapier1 zur Neuordnung des Vorschriften- und Regelwerks im Arbeitsschutz vom 31. August 2011) erarbeitet. Inhalt 1 Anwendungsbereich 2 Allgemeines 3 Liste der Einstufungen der Parasiten 3.1 Vorbemerkungen 3.2 Einstufung der Endoparasiten von Mensch und Haustieren (einschließlich -
Molecular Detection of Human Parasitic Pathogens
MOLECULAR DETECTION OF HUMAN PARASITIC PATHOGENS MOLECULAR DETECTION OF HUMAN PARASITIC PATHOGENS EDITED BY DONGYOU LIU Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2013 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20120608 International Standard Book Number-13: 978-1-4398-1243-3 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. -
Hymenolepis Nana Is a Ubiquitous Parasite, Found Throughout Many Developing and Developed Countries
Characterisation of Community-Derived Hymenolepis Infections in Australia Marion G. Macnish BSc. (Medical Science) Hons Division of Veterinary and Biomedical Sciences Murdoch University Western Australia This thesis is presented for the degree of Doctor of Philosophy of Murdoch University 2001 I declare that this thesis is my own account of my research and contains as its main work which has not been submitted for a degree at any other educational institution. ………………………………………………. (Marion G. Macnish) Characterisation of Community-Derived Hymenolepis Infections in Australia ii Abstract Hymenolepis nana is a ubiquitous parasite, found throughout many developing and developed countries. Globally, the prevalence of H. nana is alarmingly high, with estimates of up to 75 million people infected. In Australia, the rates of infection have increased substantially in the last decade, from less than 20% in the early 1990’s to 55 - 60% in these same communities today. Our knowledge of the epidemiology of infection of H. nana is hampered by the confusion surrounding the host specificity and taxonomy of this parasite. The suggestion of the existence of two separate species, Hymenolepis nana von Siebold 1852 and Hymenolepis fraterna Stiles 1906, was first proposed at the beginning of the 20th century. Despite ongoing discussions in the subsequent years it remained unclear, some 90 years later, whether there were two distinct species, that are highly host specific, or whether they were simply the same species present in both rodent and human hosts. The ongoing controversy surrounding the taxonomy of H. nana has not yet been resolved and remains a point of difference between the taxonomic and medical literature. -
The Complete Mitochondrial Genome of Echinostoma Miyagawai
Infection, Genetics and Evolution 75 (2019) 103961 Contents lists available at ScienceDirect Infection, Genetics and Evolution journal homepage: www.elsevier.com/locate/meegid Research paper The complete mitochondrial genome of Echinostoma miyagawai: Comparisons with closely related species and phylogenetic implications T Ye Lia, Yang-Yuan Qiua, Min-Hao Zenga, Pei-Wen Diaoa, Qiao-Cheng Changa, Yuan Gaoa, ⁎ Yan Zhanga, Chun-Ren Wanga,b, a College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China b College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China ARTICLE INFO ABSTRACT Keywords: Echinostoma miyagawai (Trematoda: Echinostomatidae) is a common parasite of poultry that also infects humans. Echinostoma miyagawai Es. miyagawai belongs to the “37 collar-spined” or “revolutum” group, which is very difficult to identify and Echinostomatidae classify based only on morphological characters. Molecular techniques can resolve this problem. The present Mitochondrial genome study, for the first time, determined, and presented the complete Es. miyagawai mitochondrial genome. A Comparative analysis comparative analysis of closely related species, and a reconstruction of Echinostomatidae phylogeny among the Phylogenetic analysis trematodes, is also presented. The Es. miyagawai mitochondrial genome is 14,416 bp in size, and contains 12 protein-coding genes (cox1–3, nad1–6, nad4L, cytb, and atp6), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs), and one non-coding region (NCR). All Es. miyagawai genes are transcribed in the same direction, and gene arrangement in Es. miyagawai is identical to six other Echinostomatidae and Echinochasmidae species. The complete Es. miyagawai mitochondrial genome A + T content is 65.3%, and full- length, pair-wise nucleotide sequence identity between the six species within the two families range from 64.2–84.6%. -
Comparative Genomics of the Major Parasitic Worms
Comparative genomics of the major parasitic worms International Helminth Genomes Consortium Supplementary Information Introduction ............................................................................................................................... 4 Contributions from Consortium members ..................................................................................... 5 Methods .................................................................................................................................... 6 1 Sample collection and preparation ................................................................................................................. 6 2.1 Data production, Wellcome Trust Sanger Institute (WTSI) ........................................................................ 12 DNA template preparation and sequencing................................................................................................. 12 Genome assembly ........................................................................................................................................ 13 Assembly QC ................................................................................................................................................. 14 Gene prediction ............................................................................................................................................ 15 Contamination screening ............................................................................................................................ -
Resistant Pseudosuccinea Columella Snails to Fasciola Hepatica (Trematoda) Infection in Cuba : Ecological, Molecular and Phenotypical Aspects Annia Alba Menendez
Comparative biology of susceptible and naturally- resistant Pseudosuccinea columella snails to Fasciola hepatica (Trematoda) infection in Cuba : ecological, molecular and phenotypical aspects Annia Alba Menendez To cite this version: Annia Alba Menendez. Comparative biology of susceptible and naturally- resistant Pseudosuccinea columella snails to Fasciola hepatica (Trematoda) infection in Cuba : ecological, molecular and phe- notypical aspects. Parasitology. Université de Perpignan; Instituto Pedro Kouri (La Havane, Cuba), 2018. English. NNT : 2018PERP0055. tel-02133876 HAL Id: tel-02133876 https://tel.archives-ouvertes.fr/tel-02133876 Submitted on 20 May 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Délivré par UNIVERSITE DE PERPIGNAN VIA DOMITIA En co-tutelle avec Instituto “Pedro Kourí” de Medicina Tropical Préparée au sein de l’ED305 Energie Environnement Et des unités de recherche : IHPE UMR 5244 / Laboratorio de Malacología Spécialité : Biologie Présentée par Annia ALBA MENENDEZ Comparative biology of susceptible and naturally- resistant Pseudosuccinea columella snails to Fasciola hepatica (Trematoda) infection in Cuba: ecological, molecular and phenotypical aspects Soutenue le 12 décembre 2018 devant le jury composé de Mme. Christine COUSTAU, Rapporteur Directeur de Recherche CNRS, INRA Sophia Antipolis M. Philippe JARNE, Rapporteur Directeur de recherche CNRS, CEFE, Montpellier Mme. -
Helminth Therapy – from the Parasite Perspective
Trends in Parasitology Opinion Helminth Therapy – From the Parasite Perspective Kateřina Sobotková,1,4 William Parker,2,4 Jana Levá,1,3 Jiřina Růžková,1 Julius Lukeš,1,3 and Kateřina Jirků Pomajbíková1,3,* Studies in animal models and humans suggest that intentional exposure to hel- Highlights minths or helminth-derived products may hold promise for treating chronic Helminth therapy (HT) appears to be a inflammatory-associated diseases (CIADs). Although the mechanisms underly- promising concept to oppose inflamma- ing ‘helminth therapy’ are being evaluated, little attention has been paid to the tory mechanisms underlying chronic inflammation-associated diseases be- actual organisms in use. Here we examine the notion that, because of the com- cause helminths are recognized as one plexity of biological symbiosis, intact helminths rather than helminth-derived of the keystones of the human biome. products are likely to prove more useful for clinical purposes. Further, weighing potential cost/benefit ratios of various helminths along with other factors, such So far, the majority of HT studies de- scribe the mechanisms by which hel- as feasibility of production, we argue that the four helminths currently in use for minths manipulate the host immune CIAD treatments in humans were selected more by happenstance than by de- system, but little consideration has been sign, and that other candidates not yet tested may prove superior. given to the actual tested helminths. Here, we summarize the knowns and unknowns about the helminths used in Dysregulation of Immune Function after Loss of Keystone Species from the HT and tested in disease models. Ecosystem of the Human Body For hundreds of millions of years, vertebrates developed intricate and extensive connections with Specific eligibility criteria need to be ad- dressed when evaluating prospective symbionts in their environment and inside their own bodies. -
Identification of Immunogenic Proteins of the Cysticercoid of Hymenolepis
Sulima et al. Parasites & Vectors (2017) 10:577 DOI 10.1186/s13071-017-2519-4 RESEARCH Open Access Identification of immunogenic proteins of the cysticercoid of Hymenolepis diminuta Anna Sulima1, Justyna Bień2, Kirsi Savijoki3, Anu Näreaho4, Rusłan Sałamatin1,5, David Bruce Conn6,7 and Daniel Młocicki1,2* Abstract Background: A wide range of molecules are used by tapeworm metacestodes to establish successful infection in the hostile environment of the host. Reports indicating the proteins in the cestode-host interactions are limited predominantly to taeniids, with no previous data available for non-taeniid species. A non-taeniid, Hymenolepis diminuta, represents one of the most important model species in cestode biology and exhibits an exceptional developmental plasticity in its life-cycle, which involves two phylogenetically distant hosts, arthropod and vertebrate. Results: We identified H. diminuta cysticercoid proteins that were recognized by sera of H. diminuta-infected rats using two-dimensional gel electrophoresis (2DE), 2D-immunoblotting, and LC-MS/MS mass spectrometry. Proteomic analysis of 42 antigenic spots revealed 70 proteins. The largest number belonged to structural proteins and to the heat-shock protein (HSP) family. These results show a number of the antigenic proteins of the cysticercoid stage, which were present already in the insect host prior to contact with the mammal host. These are the first parasite antigens that the mammal host encounters after the infection, therefore they may represent some of the molecules important in host-parasite interactions at the early stage of infection. Conclusions: These results could help in understanding how H. diminuta and other cestodes adapt to their diverse and complex parasitic life-cycles and show universal molecules used among diverse groups of cestodes to escape the host response to infection. -
Praziquantel Treatment in Trematode and Cestode Infections: an Update
Review Article Infection & http://dx.doi.org/10.3947/ic.2013.45.1.32 Infect Chemother 2013;45(1):32-43 Chemotherapy pISSN 2093-2340 · eISSN 2092-6448 Praziquantel Treatment in Trematode and Cestode Infections: An Update Jong-Yil Chai Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describ- ing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, het- erophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hyme- nolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resis- tance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity -
Keyword Index
International Journal for Parasitology 49 (2019) XI–XV Contents lists available at ScienceDirect International Journal for Parasitology journal homepage: www.elsevier.com/locate/ijpara Keyword index Volume 49 (2019) b-Tubulin, 13 Avian host, 579 14-3-3 protein, 355 Babesia bovis, 127 16S rRNA gene, 247 Babesia divergens, 175 18S, 859 Babesia duncani,95 Babesia microti, 145, 165, 175 Abattoir, 867 Babesia, 115, 139, 153, 183 Abundance–variance relationships, 83 Adaptations, 789 Babesiosis, 95, 105, 139, 145, 165, 183 Adeleorina, 375 Bacillus subtilis, 999 Aelurostrongylus abstrusus, 449 Bangladesh, 555 Africa, 27 Batillaria attramentaria, 1023 Agrobacterium tumefaciens, 999 BBEC, 127 Albendazole, 541 Behavior, 37, 805 Alien species, 625 Behaviour, 407, 837 Alpha 2-macroglobulin, 747 Benzimidazole, 397 Alzheimer’s disease, 747 Benzimidazoles, 13 Amastigotes, 423 Beta diversity, 437 Ancylostoma caninum, 397 Beta-cypermethrin resistance, 715 Animal model, 963, 975 Beta-oxidation, 647 Anisakis simplex sensu lato, 933 Bighorn sheep, 789 Annotation, 105 Bioclimatic associations, 27 Anoplocephala perfoliata, 885 Biodiversity, 407, 1075 Anthelmintic resistance, 397, 847 Biodiversity loss, 225 Anthelmintic treatment, 449 Biomphalaria glabrata, 1049 Anthelmintics, 13, 489 Bird host, 1005 Anti-Leishmania antibodies, 893 Birds, 27 Anticoagulant, 337 Blattella germanica, 715 Apicomplexa, 175, 375 Borrelia burgdorferi, 145, 165 Apicomplexa, 115 Bovine, 867 Apicomplexan, 153 Brazil, 301 Apicoplast, 105, 375 Breeding, 901 Apis mellifera, 605, 657 Brood -
Cryptic Diversity in Hymenolepidid Tapeworms Infecting Humans
CORE Metadata, citation and similar papers at core.ac.uk Provided by Helsingin yliopiston digitaalinen arkisto Parasitology International 65 (2016) 83–86 Contents lists available at ScienceDirect Parasitology International journal homepage: www.elsevier.com/locate/parint Short communication Cryptic diversity in hymenolepidid tapeworms infecting humans Agathe Nkouawa a,1, Voitto Haukisalmi b,1, Tiaoying Li c,1,MinoruNakaoa,⁎,1, Antti Lavikainen d, Xingwang Chen c, Heikki Henttonen e, Akira Ito a a Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan b Finnish Museum of Natural History Luomus, University of Helsinki, Helsinki, Finland c Institute of Parasitic Diseases, Sichuan Center for Disease Control and Prevention, Chengdu, China d Department of Bacteriology and Immunology/Immunobiology Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland e Natural Resources Institute Finland (Luke), Vantaa, Finland article info abstract Article history: An adult hymenolepidid tapeworm was recovered from a 52-year-old Tibetan woman during a routine epidemi- Received 22 July 2015 ological survey for human taeniasis/cysticercosis in Sichuan, China. Phylogenetic analyses based on sequences of Received in revised form 25 October 2015 nuclear 28S ribosomal DNA and mitochondrial cytochrome c oxidase subunit 1 showed that the human isolate Accepted 28 October 2015 is distinct from Hymenolepis diminuta and Hymenolepis nana, the common parasites causing human Available online 29 October 2015 hymenolepiasis. Proglottids of the human isolate were unfortunately unsuitable for morphological identification. Keywords: However, the resultant phylogeny demonstrated the human isolate to be a sister species to Hymenolepis hibernia Hymenolepiasis from Apodemus mice in Eurasia. The present data clearly indicate that hymenolepidid tapeworms causing human Hymenolepis diminuta infections are not restricted to only H.