Changes in the Three-Dimensional Angular Vestibulo-Ocular Reflex Following Intratympanic Gentamicin for Menieres Disease
JARO 03: 430±443 82002) DOI: 10.1007/s101620010053 JARO Journal of the Association for Research in Otolaryngology Changes in the Three-Dimensional Angular Vestibulo-Ocular Re¯ex following Intratympanic Gentamicin for MeÂnieÁre's Disease 1 1±3 4,5 1 JOHN P. CAREY, LLOYD B. MINOR, GRACE C.Y. PENG, CHARLES C. DELLA SANTINA, 6 7 PHILLIP D. CREMER, AND THOMAS HASLWANTER 1 1Department of Otolaryngology±Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA 2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA 3Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA 4Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA 1 5Department of Biomedical Engineering, Catholic University of America, Washington, DC 20064, USA 6Eye and Ear Research Unit, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia 7Department of Neurology, ZuÈrich University Hospital, ZuÈrich, Switzerland Received: 19 June 2000; Accepted: 21 January 2002; Online publication: 26 March 2002 ABSTRACT these gain values and those for head thrusts that ex- cited the contralateral canals were <2%. In contrast, The 3-dimensional angular vestibulo-ocular re¯exes caloric asymmetries averaged 40% 32%. Intra- 8AVOR) elicited by rapid rotary head thrusts were tympanic gentamicin resulted in decreased gains studied in 17 subjects with unilateral MeÂnieÁre's attributable to each canal on the treated side: disease before and 2±10 weeks after treatment with 0.40 0.12 8HC), 0.35 0.14 8AC), 0.31 0.14 8PC) intratympanic gentamicin and in 13 subjects after 8p < 0.01). However, the gains attributable to con- surgical unilateral vestibular destruction 8SUVD).
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