The Rockefeller Institute Quarterly 1961, Vol. 4, No. 4 the Rockefeller University

Total Page:16

File Type:pdf, Size:1020Kb

The Rockefeller Institute Quarterly 1961, Vol. 4, No. 4 the Rockefeller University Rockefeller University Digital Commons @ RU The Rockefeller Institute Quarterly The Rockefeller University Newsletters Winter 1961 The Rockefeller Institute Quarterly 1961, vol. 4, no. 4 The Rockefeller University Follow this and additional works at: http://digitalcommons.rockefeller.edu/ rockefeller_institute_quarterly Recommended Citation The Rockefeller University, "The Rockefeller Institute Quarterly 1961, vol. 4, no. 4" (1961). The Rockefeller Institute Quarterly. Book 16. http://digitalcommons.rockefeller.edu/rockefeller_institute_quarterly/16 This Book is brought to you for free and open access by the The Rockefeller University Newsletters at Digital Commons @ RU. It has been accepted for inclusion in The Rockefeller Institute Quarterly by an authorized administrator of Digital Commons @ RU. For more information, please contact [email protected]. STITUTE WINTER 1961 THE ROCKEFELLER INSTITUTE. A GRADUATE UNIVERSITY AND RESEARCH CENTEB ' The park-like character of the institute's campus is shown on the cover of this issue. The view is toward the south from Caspary Auditorium across the 66th street driveway lined with sycamores nearly half a century old. In the distance is the facade of the South Laboratory, two blocks away, past the lawn and the gardens facing the Graduate Students Residence Hall. The photo- graph is by Vandivert,photomechanically processed to simulate a pen drawing. .- editors,ChristianA.HerterandJohnJ. THE RISE OF BIOLOGICALCHEMISTRY: . Abel, were Levene and Jacques Loeb. Abel and Herter considered it important for the THE INSTITUTE AND THE SOCIETY long-range stability of the Journal that it should be incorporated. Accordingly this PROFESSORFRITZ LIPMANN'Sterm staff in 1908, and Christian A. Herter, was arranged under the law? of the State as President of the American Society of first Treasurer of the Institute, was also a of New York, the original incorporators Biological Chemists during 1960-1961 is charter member. Other charter members being Abel, E. K. Dunham, soon to come a reminder of the parallel and often inter- of the Society in 1906 were to come to the to the Institute, Christian Herter, Reid dependent histories of the Society and The Institute: Jacques Loeb, then at the Uni- Hunt, and A. N. Richards, who, in igoi Rockefeller Institute during the past half- versity of California, and Francis H. Mc- had been one of the first Rockefeller Insti- century. The year of the founding of the Crudden, then at Harvard, both of whom tute scholars. Society, 1906, was also the year of the came in 1910. Two junior members of Dr. Richards, who last Spring received opening of the Institute's laboratories; the Institute staff appointed in 1907 and the Institute's degree of Doctor of Science, many distinguished scientists have been today Members Emeriti, D. D. Van Slyke honoris causa, had done research on prob- associated with both; and for a critical and Walter A. Jacobs, were elected to the lems of interest to Herter, and because of decade the Institute published what be- Society at its third annual meeting. their association Dr. Herter turned to came the Society's journal, the Journal of Dr. P. A. Levene, the Institute's first him for assistance with the new journal. Biological Chemistry. biological chemist, regarded the poten- Richards served as assistant editor from Soon after the founding of the Institute tialities of the Society as important to the the beginning, much involved in dealings in 1901, biological chemistry began to development of biological chemistry, as with the printer. play an important part in its program. In can be seen from an address he gave at the igo 5, Simon Flexner, recognizing the annual meeting of the Society in 1919. THE JBC COMES TO THE INSTITUTE growing importance of biochemistry, ap- He drew attention to the very great debt In igio Christian Herter's untimely .. pointed P.A. Levene, who at thirty-five modern science owes to the efforts of the death raised severe problems for the had become a pioneer in biochemical re- ancient societies and academies of science. Journal. A. N. Richards has written: "It search in its fundamental aspects in this By contrast, he said, most modern societies is safe to assert that during the years of - country. did far less to advance the cause of science. Dr. Herter's editorship, 1905-lo, the Referring to the aim of the Society of Bio- Journal was conducted at very consider- FOUNDING THE SOCIETY logical Chemists as being "to enhance the able loss. How great it was, I have no When the Society of Biological Chem- social usefulness of the biological chemist, means of knowing. I believe it to have --J ists was officially organized in the winter on the one hand and, on the other, to im- been borne exclusively by Dr. Herter." To . r"-q of 1906 in New York City, John J. Abel of prove his facilities for work, whether his enable the Journal to continue, friends of * -.; s The Johns Hopkins University stated at work be teaching or investigating," he Dr. Herter and relatives of Mrs. Herter as- -1 Tc the organizational meeting that there were asked : "Will this. ..society live to record sembled the Christian A. Herter Memorial -* ' I then "about loo active workers in this important service, or will it vegetate a pale, Fund to the amount of $4o,ooo. Contrib- . rT field, using the term in its widest sense." colourless existence? This will depend on utors included Dr. and Mrs. Edward K. - $ Though the entire scientific staff of The the spirit in which you join it." Dunham and Dr. and Mrs. L. Emmett -04 Rockefeller Institute at that time num- The Journal of Biological Chemistry Holt. Dr. Holt, a physician actively in- -- - bered less than a score, two were among was established shortly before the Society terested in biological chemistry, was a the charter members of the Society: P. A. itself was organized. Indeed, it was the member of the original board of the Insti- Levene and W. A. Beatty. Two other JournaPs editorial committee that formed tute as well as its first Secretary. charter members, Edward K. Dunham the nucleus of the Society. Among the Simon Flexner, Director of the Insti- and G. M. Meyer, joined the Institute twenty-four listed as "collaborators" of the (continued on page two) - . %--:. BIOLOGICAL CHEMISTRY philosophy from Princeton in 1938. He (continued from page one) joined the research staff at Bell Telephone Laboratories in 1939, becoming Vice Pres- tute, replaced Dr. Herter as President of ident in 1955. the Journal of Biological Chemistry, Inc., Dr. Baker is a member of the President's and H. D. Dakin of Herter's laboratory Board of Consultants on Foreign Intelli- took charge of the editorial office. Dr. gence Activities and a member of the Na- Richards became managing editor in 1910 tional Science Board, as well as advisory and carried the responsibilities of this groups of the National Academy of Sci- position until 1914, when he concluded ences-National Research Council, the that it interfered too much with his duties National Security Agency, and the Depart- as Professor of Pharmacology in the Uni- ment of Defense. He is also a past member versity of Pennsylvania. The editorial and of the President's Science Advisory Com- publication work was then taken over by mittee and the National Science Informa- The Rockefeller Institute. Dr. Van Slyke tion Council. became managing editor and the publica- Among his numerous professional activ- tion office of the Institute handled the ities, Dr. Baker is a member and past preparation of manuscripts for the printers. councilor of the American Chemical So- For eleven years, until 1925, the Institute ciety, member of the American Physical acted as publisher of the Journal with WILLIAM 0. BAKER, newly-elected Society, the Editorial Board of the Journal editorial responsibility under the Directors Trustee, is Vice President-Research at the of Polymer Science, the Advisory Board of of the Journal. The Journal was virtually Bell Telephone Laboratories. Dr. Baker is the Chemical and Engineering News and self-supporting during the time that it was a physical chemist whose research on the Advisory Editorial Board of Research published by the Institute due to efforts macromolecules has contributed to funda- Management. made by Richards and Dakin to increase mental science as well as to important He is a Trustee of the Mellon Institute the circulation. practical applications. and serves on Visiting Committees for Editorial and management activity in- After receiving a bachelor of science Chemistry of Harvard, Princeton and Rut- evitably involves peripheral overhead costs degree from Washington College in 193 5, gers Universities and the School of Engi- that may not be reflected in the formal Dr. Baker obtained the degree of doctor of neering of New York University. financial statements. As the volume of the Journal increased, the Institute found that more than a third of all of its publication effort was being devoted to the Journal of editor until he, Dakin, and Dr. H. T. Hastings (1945-46), who had been at the Biographical Chemistry. When Dr. Flex- Clarke were able to persuade the late Dr. Institute from 192i to 1926; and Vincent ner indicated to Dakin in 1924 that the R. J. Anderson to accept the position in du Vigneaud (195 I), Trustee of the In- Institute would welcome relief from this 1937. Anderson continued as managing stitute since 1949. In addition to these, burden, Dakin replied: "I am not going editor of the Journal for twenty-one years who held various other offices as well, to waste much time telling you: (a) that I until his retirement in 1958. Stanford Moore, Professor at the Institute, would rather have the J.B.C. continue at An even longer record of devotion was served as Treasurer of the Society from the R.I., (b) that we are mighty grateful that of Miss Mary Smalley who had been 1957 to 1959.
Recommended publications
  • Nhbs Annual New and Forthcoming Titles Issue: 2000 Complete January 2001 [email protected] +44 (0)1803 865913
    nhbs annual new and forthcoming titles Issue: 2000 complete January 2001 [email protected] +44 (0)1803 865913 The NHBS Monthly Catalogue in a complete yearly edition Zoology: Mammals Birds Welcome to the Complete 2000 edition of the NHBS Monthly Catalogue, the ultimate Reptiles & Amphibians buyer's guide to new and forthcoming titles in natural history, conservation and the Fishes environment. With 300-400 new titles sourced every month from publishers and research organisations around the world, the catalogue provides key bibliographic data Invertebrates plus convenient hyperlinks to more complete information and nhbs.com online Palaeontology shopping - an invaluable resource. Each month's catalogue is sent out as an HTML Marine & Freshwater Biology email to registered subscribers (a plain text version is available on request). It is also General Natural History available online, and offered as a PDF download. Regional & Travel Please see our info page for more details, also our standard terms and conditions. Botany & Plant Science Prices are correct at the time of publication, please check www.nhbs.com for the Animal & General Biology latest prices. Evolutionary Biology Ecology Habitats & Ecosystems Conservation & Biodiversity Environmental Science Physical Sciences Sustainable Development Data Analysis Reference Mammals Activity Patterns in Small Mammals 318 pages | 59 figs, 11 tabs | Springer An Ecological Approach Hbk | 2000 | 354059244X | #109391A | Edited by S Halle and NC Stenseth £100.00 BUY Links chronobiology with behavioural and evolutionary ecology, drawing on research on mammals ranging from mongooses and civets to weasels, martens and shrews. .... African Rhino 92 pages | B/w photos, figs, tabs | IUCN Status Survey and Conservation Action Plan Pbk | 1999 | 2831705029 | #106031A | Richard Emslie and Martin Brooks £15.00 BUY Action plan aimed at donors, government and non-government organisations, and all those involved in rhino conservation.
    [Show full text]
  • 2004 Albert Lasker Nomination Form
    albert and mary lasker foundation 110 East 42nd Street Suite 1300 New York, ny 10017 November 3, 2003 tel 212 286-0222 fax 212 286-0924 Greetings: www.laskerfoundation.org james w. fordyce On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination Chairman neen hunt, ed.d. for the 2004 Albert Lasker Medical Research Awards. President mrs. anne b. fordyce The Awards will be offered in three categories: Basic Medical Research, Clinical Medical Vice President Research, and Special Achievement in Medical Science. This is the 59th year of these christopher w. brody Treasurer awards. Since the program was first established in 1944, 68 Lasker Laureates have later w. michael brown Secretary won Nobel Prizes. Additional information on previous Lasker Laureates can be found jordan u. gutterman, m.d. online at our web site http://www.laskerfoundation.org. Representative Albert Lasker Medical Research Awards Program Nominations that have been made in previous years may be updated and resubmitted in purnell w. choppin, m.d. accordance with the instructions on page 2 of this nomination booklet. daniel e. koshland, jr., ph.d. mrs. william mccormick blair, jr. the honorable mark o. hatfied Nominations should be received by the Foundation no later than February 2, 2004. Directors Emeritus A distinguished panel of jurors will select the scientists to be honored. The 2004 Albert Lasker Medical Research Awards will be presented at a luncheon ceremony given by the Foundation in New York City on Friday, October 1, 2004. Sincerely, Joseph L. Goldstein, M.D. Chairman, Awards Jury Albert Lasker Medical Research Awards ALBERT LASKER MEDICAL2004 RESEARCH AWARDS PURPOSE AND DESCRIPTION OF THE AWARDS The major purpose of these Awards is to recognize and honor individuals who have made signifi- cant contributions in basic or clinical research in diseases that are the main cause of death and disability.
    [Show full text]
  • Barbara Mcclintock's World
    Barbara McClintock’s World Timeline adapted from Dolan DNA Learning Center exhibition 1902-1908 Barbara McClintock is born in Hartford, Connecticut, the third of four children of Sarah and Thomas Henry McClintock, a physician. She spends periods of her childhood in Massachusetts with her paternal aunt and uncle. Barbara at about age five. This prim and proper picture betrays the fact that she was, in fact, a self-reliant tomboy. Barbara’s individualism and self-sufficiency was apparent even in infancy. When Barbara was four months old, her parents changed her birth name, Eleanor, which they considered too delicate and feminine for such a rugged child. In grade school, Barbara persuaded her mother to have matching bloomers (shorts) made for her dresses – so she could more easily join her brother Tom in tree climbing, baseball, volleyball, My father tells me that at the and football. age of five I asked for a set of tools. He My mother used to did not get me the tools that you get for an adult; he put a pillow on the floor and give got me tools that would fit in my hands, and I didn’t me one toy and just leave me there. think they were adequate. Though I didn’t want to tell She said I didn’t cry, didn’t call for him that, they were not the tools I wanted. I wanted anything. real tools not tools for children. 1908-1918 McClintock’s family moves to Brooklyn in 1908, where she attends elementary and secondary school. In 1918, she graduates one semester early from Erasmus Hall High School in Brooklyn.
    [Show full text]
  • The Contributions of George Beadle and Edward Tatum
    | PERSPECTIVES Biochemical Genetics and Molecular Biology: The Contributions of George Beadle and Edward Tatum Bernard S. Strauss1 Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637 KEYWORDS George Beadle; Edward Tatum; Boris Ephrussi; gene action; history It will concern us particularly to take note of those cases in Genetics in the Early 1940s which men not only solved a problem but had to alter their mentality in the process, or at least discovered afterwards By the end of the 1930s, geneticists had developed a sophis- that the solution involved a change in their mental approach ticated, self-contained science. In particular, they were able (Butterfield 1962). to predict the patterns of inheritance of a variety of charac- teristics, most morphological in nature, in a variety of or- EVENTY-FIVE years ago, George Beadle and Edward ganisms although the favorites at the time were clearly Tatum published their method for producing nutritional S Drosophila andcorn(Zea mays). These characteristics were mutants in Neurospora crassa. Their study signaled the start of determined by mysterious entities known as “genes,” known a new era in experimental biology, but its significance is to be located at particular positions on the chromosomes. generally misunderstood today. The importance of the work Furthermore, a variety of peculiar patterns of inheritance is usually summarized as providing support for the “one gene– could be accounted for by alteration in chromosome struc- one enzyme” hypothesis, but its major value actually lay both ture and number with predictions as to inheritance pattern in providing a general methodology for the investigation of being quantitative and statistical.
    [Show full text]
  • Genes, Genomes and Genetic Analysis
    © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION UNIT 1 © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FORDefining SALE OR DISTRIBUTION and WorkingNOT FOR SALE OR DISTRIBUTION with Genes © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Chapter 1 Genes, Genomes, and Genetic Analysis Chapter 2 DNA Structure and Genetic Variation © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Molekuul/Science Photo Library/Getty Images. © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC. NOT FOR SALE OR DISTRIBUTION 9781284136609_CH01_Hartl.indd 1 08/11/17 8:50 am © Jones & Bartlett Learning, LLC
    [Show full text]
  • DNA the Central Dogma 3.4: Genes, Central Dogma • 3.5: Cell Division-Mitosis and Meiosis, • 3.6: Chromosomal Involvement, DNA Level of Involvement
    U3 DNA the Central Dogma 3.4: Genes, Central Dogma • 3.5: Cell Division-Mitosis and Meiosis, • 3.6: Chromosomal involvement, DNA level of involvement. CENTRAL DOGMA • What is the central dogma of DNA? • The central dogma of molecular biology describes the two-step process, transcription and translation, by which the information in genes flows into proteins: DNA → RNA → protein. Transcription is the synthesis of an RNA copy of a segment of DNA. • Transcription is the synthesis of an RNA copy of a segment of DNA. RNA is synthesized by the enzyme RNA polymerase. Genes Are Located on Chromosomes (1910 – 1920s) Thomas Hunt Morgan discovers that genes are located on chromosomes. Working on fruit flies, he concludes that certain traits are linked to gender and that those traits are probably carried on one of the sex chromosomes (X or Y). He hypothesizes that other genes are also carried on specific chromosomes. Using chromosome recombination, he and his students map the locations of genes on chromosomes. Morgan and his students write the seminal book “The Mechanism of Mendelian Heredity”. Genes Control Biochemical Events George Beadle and Edward Tatum (1930) discover through experiments on neurospora, a bread mold, that genes are responsible for the production of enzymes. Their report is the genesis of the "one gene-one enzyme" concept. DNA Is the Genetic Material (1928, 1944, 1952) ◊ Several scientists prove that DNA is the chemical basis of genetic information. ◊ Oswald Avery proves that DNA carries genetic information. ◊ Linus Pauling discovers that many proteins take the shape of a spiral, like a spring coil.
    [Show full text]
  • Table of Contents (PDF)
    CONTENTS NU~mER 1, JULr, 1950 The Effect of Adrenoeorticotrophic Hormone on Circulating Antibody Levels. Joan A. de Vries ................................... '..................................... 1 A Nomographic Probit Solution for the Median Effective Dose (EDs0). Walter Koch and Deborah Kaplan ........................................................... 7 A Quantitative Complement Fixation Test: Titration of Luetic Sera by the Unit of 50 Per Cent Hemolysis. George J. Stein and Dang Van Ngu ......................... 17 The Action of Enzymes in Hemagglutinating Systems. II. Agglutinating Properties of Trypsin-Modified Red Cells with Anti-Rh-Sera. Warren E. Wheeler, A. Leonard Luhby and Mary Louise L. Scholl .............................................. 39 Antigen-Antibody Reactions in Agar. I. Complexity of Antigen-Antibod~ Systems as Demonstrated by a Serum-Agar Technic. J. Munoz and Elmer L. Becker ......... 47 Tuberculostatic Activity of Blood and Urine From Animals Given Gliotoxin. Ralph Tompsett, Walsh McDermott and John G. Kidd ................................ 59 A General Method for the Specific Purification of Antiprotein Antibodies. L. A. Stern- berger and David Pressman ..................................................... 65 The Hypotensive Action of Influenza Virus on Rats. Hsioh-Teh Chang and J. Emerson Kempf ......................................................................... 75 Anti (Streptococcal Desoxyribonuclease. Occurrence in the Sera of Patients Treated with Streptococcal Concentrates Containing Streptodornase.
    [Show full text]
  • PHS 398/2590 (Rev. 06/09), Biographical Sketch Format Page
    Program Director/Principal Investigator (Last, First, Middle): BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Emine Ercikan Abali Associate Professor of Biochemistry, eRA COMMONS USER NAME (credential, e.g., agency login) Pharmacology and Medicine ABALIEM EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) INSTITUTION AND LOCATION DEGREE MM/YY FIELD OF STUDY (if applicable) University of Southwestern Louisiana, Lafayette, LA B.Sc. 1982-1986 Chemistry University of Southwestern Louisiana, Lafayette, LA M.S. 1988-1988 Chemistry The Ohio State University, Columbus, OH Ph.D. student 1989-1990 Chemistry Cornell University Graduate School of Medical Ph.D. 1990-1996 Pharmacology Sciences and Memorial Sloan Kettering Cancer Center, New York, NY Memorial Sloan Kettering Cancer Center, NY, NY Postdoc 1996-1998 Molecular Therapeutics Columbia University, NY, NY Postdoc 1998-1999 Biological Sciences (10months) A. Personal Background The overall aim of this project is to use dihydrofolate reductase (DHFR) as a prototype for other NAD(P) binding dehydrogenases to identify novel NAD(P) analogues that specifically target the NADPH binding site of DHFR as potent inhibitors of cancer cells. Specifically, we plan to investigate metabolism of NADPS in cell lines and in xenograft animal and to perform in silico screening of the NADPH binding site to identify potential new inhibitors targeted to DHFR. Lastly, we will determine further characterize the mechanism of action of NADPS in accelerating the degradation of DHFR in order to address development of drug-resistance to this new class of inhibitors.
    [Show full text]
  • A Giant of Genetics Cornell University As a Graduate Student to Work on the Cytogenetics of George Beadle, an Uncommon Maize
    BOOK REVIEW farm after obtaining his baccalaureate at Nebraska Ag, he went to A giant of genetics Cornell University as a graduate student to work on the cytogenetics of George Beadle, An Uncommon maize. On receiving his Ph.D. from Cornell in 1931, Beadle was awarded a National Research Council fellowship to do postdoctoral work in T. H. Farmer: The Emergence of Genetics th Morgan’s Division of Biology at Caltech, where the fruit fly, Drosophila, in the 20 Century was then being developed as the premier experimental object of van- By Paul Berg & Maxine Singer guard genetics. On encountering Boris Ephrussi—a visiting geneticist from Paris— Cold Spring Harbor Laboratory Press, at Caltech, Beadle began his work on the mechanism of gene action. 2003 383 pp. hardcover, $35, He and Ephrussi studied certain mutants of Drosophila whose eye ISBN 0-87969-688-5 color differed in various ways from the red hue characteristic of the wild-type fly. They inferred from these results that the embryonic Reviewed by Gunther S Stent development of animals consists of a series of chemical reactions, each step of which is catalyzed by a specific enzyme, whose formation is, in http://www.nature.com/naturegenetics turn, controlled by a specific gene. This inference provided the germ for Beadle’s one-gene-one-enzyme doctrine. To Beadle and Ephrussi’s “Isaac Newton’s famous phrase reminds us that major advances in disappointment, however, a group of German biochemists beat them science are made ‘on the shoulders of giants’. Too often, however, the to the identification of the actual chemical intermediates in the ‘giants’ in our field are unknown to many colleagues and biosynthesis of the Drosophila eye color pigments.
    [Show full text]
  • Joshua Lederberg – in Memoriam
    ARTICLE-IN-A-BOX Joshua Lederberg – In Memoriam The foundations of the young science of molecular biology were laid towards the middle of the last century, primarily resting on a series of outstanding discoveries where microorganisms played a significant role. The exploitation of bacteria to address fundamental questions related to the nature of genes and how they function unleashed a steady stream of path-breaking discoveries during the 1940s and 50s. This was rather ironic since the term bacterial genetics would have been considered an oxymoron only a few years ago as the idea of bacteria possessing genes was alien to most geneticists who were busy working with plants, flies, and fungi. Joshua Lederberg, who passed away in February 2008, was one of the undisputed leaders of this molecular biology revolution. Lederberg’s work led to the discovery of two forms of genetic exchange in bacteria – conjugation and transduction. These discoveries had an enormous impact in opening up the genetic analysis of bacteria that resulted in other major breakthroughs such as the elucidation of the mechanism of gene regulation. For his contribu- tions to microbial genetics, Lederberg shared the 1958 Nobel Prize for Physiology or Medicine with Edward Tatum and George Beadle. Lederberg’s contributions however did not confine only to the field of bacterial genetics. He was keenly interested in exotic areas such as artificial intelligence, extra-terrestrial life (exobiology) and space exploration and made significant contributions to these fields too. He also championed the cause of disarmament and elimination of biological weapons. In a sense, he was also a science journalist as he regularly contributed articles dealing with science and public issues in the Washington Post and The Chronicle.
    [Show full text]
  • Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research
    A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Hollingsworth, Joseph Rogers Working Paper Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research WZB Discussion Paper, No. P 02-003 Provided in Cooperation with: WZB Berlin Social Science Center Suggested Citation: Hollingsworth, Joseph Rogers (2002) : Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research, WZB Discussion Paper, No. P 02-003, Wissenschaftszentrum Berlin für Sozialforschung (WZB), Berlin This Version is available at: http://hdl.handle.net/10419/50229 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu P 02 – 003 RESEARCH ORGANIZATIONS AND MAJOR DISCOVERIES IN TWENTIETH-CENTURY SCIENCE: A CASE STUDY OF EXCELLENCE IN BIOMEDICAL RESEARCH J.
    [Show full text]
  • Lasker Interactive Research Nom'18.Indd
    THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will
    [Show full text]