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Chapter 2 : Gentaur Products List • WDSUB1 contains 1 SAM sterile alpha motif domain 1 U Defects in DLG3 are the cause of mental retardation X • Sodium hydrogen exchangers NHEs such as SLC9A8 are box domain and 7 WD repeats The function of WDSUB1 linked type 90 MRX90 integral transmembrane proteins that exchange extracellular remains unknown • SLC25A20 is one of several closely related mitochondrial Na for intracellular H NHEs have multiple functions including • RNF217 is an E3 ubiquitin protein ligase which accepts membrane carrier proteins that shuttle substrates between intracellular pH ho ubiquitin from E2 ubiquitin conjugating enzymes in the form cytosol and the intramitochondrial matrix space It mediates • SLCO1C1 is a member of the organic anion transporter of a thioester and then directly transfers the ubiquitin to the transport of acylcarn family SLCO1C1 is a transmembrane receptor that mediates targeted substrates • The sodium iodide symporter NIS or SLC5A5 is a key the sodium independent uptake of thyroid hormones in brain • TRIM60 contains a RING finger domain a motif present in a plasma membrane protein that mediates active I uptake in tissues This protein has part variety of functionally distinct proteins and known to be thyroid lactating breast and other tissues with an • SLC35A5 belongs to the nucleotide sugar transporter involved in protein protein and protein DNA interactions The electrogenic stoichiometry of 2 Na family SLC35A subfamily It is a multi pass membrane protein encoded by thi • SLC2A9 is a member of the SLC2A facilitative glucose protein The function of the SLC35A5 protein remains • RNF182 is a multi pass membrane protein It contains 1 transporter family Members of this family play a significant unknown RING type zinc finger The function of RNF182 remains role in maintaining glucose homeostasis SLC2A9 may play a • SLC6A15 shows structural characteristics of an Na and Cl unknown role in the development an dependent neurotransmitter transporter including 12 • HECTD2 is a probable E3 ubiquitin protein ligase which • SLC41A3 is a multi pass membrane protein It belongs to transmembrane TM domains intracellular N and C termini accepts ubiquitin from an E2 ubiquitin conjugating enzyme in the SLC41A transporter family The exact function of and large extracellular the form of a thioester and then directly transfers the SLC41A3 remains unknown • SLC25A36 belongs to the mitochondrial carrier family It ubiquitin to targeted substr • SLC27A6 is a member of the fatty acid transport protein contains 3 Solcar repeats SLC25A36 is a multi pass • TRIM54 contains a RING finger motif and is highly similar family FATP FATPs are involved in the uptake of long chain membrane protein The function of the SLC25A36 protein to the ring finger proteins RNF28 MURF1 and RNF29 fatty acids and have unique expression patterns Alternatively remains unknown MURF2 In vitro studies demonstrated that this protein spliced transcript • SLC22A11 is involved in the sodium independent transport RNF28 and RNF29 form heterodimers • SLC10A7 belongs to the sodium bile acid symporter family and excretion of organic anions some of which are • RNF212 contains 1 RING type zinc finger The function of It is a multi pass membrane protein The function of potentially toxic SLC22A11 is an integral membrane protein the RNF212 protein remains unknown SLC10A7 remains unknown and is found mainly in the kidne • RNF148 is a single pass membrane protein It contains 1 • Zinc is an essential cofactor for more than 50 classes of • SLC37A1 a member of the sugar phosphate transport PA protease associated domain and 1 RING type zinc finger enzymes It is involved in protein nucleic acid carbohydrate family transports glycerol 3 phosphate G3P between cellular The exact function of RNF148 remains unknown and lipid metabolism as well as in the control of gene compartments for its utilization in several compartment • LONRF2 contains 1 Lon domain 1 RING type zinc finger transcription growth specific biochemical pathways and 6 TPR repeats The function of the LONRF2 protein • SLC37A4 transports glucose 6 phosphate from the • SLC15A2 belongs to the PTR2 POT transporter TC 2 A 17 remains unknown cytoplasm to the lumen of the endoplasmic reticulum It forms family It is a multi pass membrane protein The expression • RNF207 contains 1 B box type zinc finger and 1 RING type with glucose 6 phosphatase the complex responsible for activity of PEPT2 SLC15A2 may be a critical factor in the zinc finger The function of the RNF207 protein remains glucose production through glycogen modulation of opioidergi unknown • This gene is one of several tumor suppressing • SLC24A6 belongs to a family of potassium dependent • Glutamic oxaloacetic transaminase is a pyridoxal subtransferable fragments located in the imprinted gene sodium calcium exchangers that maintain cellular calcium phosphate dependent enzyme which exists in cytoplasmic domain of 11p15 5 an important tumor suppressor gene homeostasis through the electrogenic countertransport of 4 and inner membrane mitochondrial forms GOT1 and GOT2 region Alterations in this region have been sodium ions for 1 calcium ion and respectively GOT plays a role in amino a • SLC25A11 catalyzes the transport of 2 oxoglutarate across • SLC25A21 is a homolog of the S cerevisiae ODC proteins • The specific function of DPY19L1 is not yet known the inner mitochondrial membrane in an electroneutral mitochondrial carriers that transport C5 C7 • MAOB belongs to the flavin monoamine oxidase family It is exchange for malate or other dicarboxylic acids and plays an oxodicarboxylates across inner mitochondrial membranes a enzyme located in the mitochondrial outer membrane It important role in several One of the species transported by ODC is 2 catalyzes the oxidative deamination of biogenic and • SLC27A2 is an isozyme of long chain fatty acid coenzyme • SLC25A28 is a mitochondrial iron transporter that mediates xenobiotic amines and plays an i A ligase family Although differing in substrate specificity iron uptake It is probably required for heme synthesis of • Carboxypeptidases are enzymes that hydrolyze C terminal subcellular localization and tissue distribution all isozymes of hemoproteins and Fe S cluster assembly in non erythroid peptide bonds The carboxypeptidase family includes metallo this family con cells The iron delivered serine and cysteine carboxypeptidases According to their • SLC13A2 belongs to the SLC13A transporter TC 2 A 47 • Organelles of the secretory and endocytic pathways are substrate specificity family NADC subfamily It is a multi pass membrane protein distinguished by their luminal acidity which is generated by • ADH4 class II alcohol dehydrogenase 4 pi subunit which is SLC13A2 cotransports of sodium ions and dicarboxylates the activity of an electrogenic vacuolar type hydrogen a member of the alcohol dehydrogenase family Members of such as succinate and citrate ATPase Progressive acidific this enzyme family metabolize a wide variety of substrates • SLC22A13 is a member of the organic cation transporter • SLC8A3 is a member of the sodium calcium exchanger including ethanol reti family SLC22A13 is a transmembrane protein involved in the integral membrane protein family Three mammalian • GTP cyclohydrolase I feedback regulatory protein binds to transport of small molecules This protein can function to isoforms in family 8 have been identified Na Ca2 exchange and mediates tetrahydrobiopterin inhibition of GTP mediate urate uptake and i proteins are involved in maintaining C cyclohydrolase I The regulatory protein GCHFR consists of a • SLC16A6 is a proton linked monocarboxylate transporter It • SLC2A13 is an H myo inositol cotransporter It can also homodimer It is postulated catalyzes the rapid transport across the plasma membrane transport related stereoisomers • CREBBP is involved in the transcriptional coactivation of of many monocarboxylates such as lactate pyruvate • SLC39A4 is a member of the zinc iron regulated many different transcription factors First isolated as a branched chain oxo acids derived transporter like protein ZIP family The transmembrane nuclear protein that binds to cAMP response element • SLC24A1 belongs to a family of potassium dependent protein is required for zinc uptake in the intestine Mutations binding protein CREB this gen sodium calcium exchangers Members of this family have 2 in the gene encoding SLC39A4 res • The membrane associated protein encoded by this gene is large hydrophilic loops and 2 sets of multiple • SLC25A46 is a members of the solute carrier family 25 a member of the superfamily of ATP binding cassette ABC transmembrane spanning segments SLC24A1 belon SLC25 which is known to transport molecules over the transporters ABC proteins transport various molecules • SLC33A1 is required for the formation of O acetylated Ac mitochondrial membrane SLC25A46 belongs to the SLC25 across extra and intra cellula gangliosides It is predicted to contain 6 to 10 family of mitochondrial carrier protei • ABCC3 is a member of the superfamily of ATP binding transmembrane domains and a leucine zipper motif in • SLC39A11 belongs to the ZIP transporter TC 2 A 5 family It cassette ABC transporters ABC proteins transport various transmembrane domain III Studies indic is a multi pass membrane protein SLC39A11 may act as a molecules across extra and intra cellular membranes ABC • SLC22A14 is a member of the organic cation transporter zinc influx transporter genes are divided into seven d family SLC22A14 is a transmembrane
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  • A W-Linked DM-Domain Gene, DM-W, Participates in Primary Ovary Development in Xenopus Laevis

    A W-Linked DM-Domain Gene, DM-W, Participates in Primary Ovary Development in Xenopus Laevis

    A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis Shin Yoshimoto*, Ema Okada*, Hirohito Umemoto*, Kei Tamura*, Yoshinobu Uno†, Chizuko Nishida-Umehara†, Yoichi Matsuda†, Nobuhiko Takamatsu*, Tadayoshi Shiba*, and Michihiko Ito*‡ *Department of Bioscience, School of Science, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan; and †Division of Genome Dynamics, Creative Research Initiative ‘‘Sousei,’’ Hokkaido University, North10 West8, Kita-ku, Sapporo, Hokkaido 060-0810, Japan Communicated by Satoshi Omura,¯ The Kitasato Institute, Tokyo, Japan, December 27, 2007 (received for review September 11, 2007) In the XX/XY sex-determining system, the Y-linked SRY genes of In some species of amphibians, sex determination is controlled most mammals and the DMY/Dmrt1bY genes of the teleost fish genetically (13), even though the animals’ sex chromosomes are medaka have been characterized as sex-determining genes that morphologically indistinguishable from the autosomes. The trigger formation of the testis. However, the molecular mechanism South African clawed frog Xenopus laevis uses the ZZ/ZW of the ZZ/ZW-type system in vertebrates, including the clawed frog system, which was demonstrated by backcrosses between sex- Xenopus laevis, is unknown. Here, we isolated an X. laevis female reversed and normal individuals (14), but its sex chromosomes genome-specific DM-domain gene, DM-W, and obtained molecular have not yet been identified. Moreover, as with other animals evidence of a W-chromosome in this species. The DNA-binding that use the ZZ/ZW system, no sex-determining gene(s) has domain of DM-W showed a strikingly high identity (89%) with that been identified.