Obesity, Fitness & Wellness Week August 2, 2003 EXPANDED REPORTING; Pg. 31 OBESITY GENOMICS AND GENETICS: Genes influencing human obesity found in chromosome region 7q22.1-7q35 Genes influencing human obesity were "Our results suggested that there could be found in chromosome region 7q22.1- two or more genes in chromosome region 7q35. 7q22.1-7q35 that influence obesity," concluded Li and coauthors. "A new region According to a study from the United found by this study (D7S692-D7S523, States, "Linkage results suggest that the 7q31.1) has the most consistent linkage region of chromosome 7 containing the results and could harbor obesity-related leptin gene cosegregates with extreme genes." obesity; however, leptin coding region mutations are rare. To investigate whether Li and associates published their study i n the leptin flanking sequence and/or a Diabetes (Linkage and linkage disequilib- larger 40-cM region (7q22.1-7q35) rium mapping of genes influencing human contributes to obesity, we genotyped indi- obesity in chromosome region 7q22.1- viduals from 200 European American 7q35. Diabetes, 2003;52(6):1557- families segregating extreme obesity and 1561). normal weight (1020 subjects) using 2 1 microsatellite markers and two single n u - For more information, contact R. Arlen cleotide polymorphisms (SNPs) and con- Price, Department of Psychiatry, Uni- ducted nonparametric linkage (NPL) versity of Pennsylvania, Center for Neu- analyses." robiology and Behavior, One Clinical Re- search Building, Room 105, 415 Curie "We also carried out transmission dise- Boulevard, Philadelphia, PA 19104, USA. quilibrium tests for 135 European E-mail:
[email protected]. American triads using 27 markers (in- cluding eight SNPs)," reported Wei-Dong Publisher contact information for the Li and collaborators at the University of journal Diabetes is: The American Diabetes Pennsylvania, Yale University, and Association, 1701 North Beauregard Michigan Technological University.