Obesity, Fitness & Wellness Week August 2, 2003 EXPANDED REPORTING; Pg. 31 OBESITY GENOMICS AND GENETICS: Genes influencing human obesity found in chromosome region 7q22.1-7q35 Genes influencing human obesity were "Our results suggested that there could be found in chromosome region 7q22.1- two or more genes in chromosome region 7q35. 7q22.1-7q35 that influence obesity," concluded Li and coauthors. "A new region According to a study from the United found by this study (D7S692-D7S523, States, "Linkage results suggest that the 7q31.1) has the most consistent linkage region of chromosome 7 containing the results and could harbor obesity-related leptin gene cosegregates with extreme genes." obesity; however, leptin coding region mutations are rare. To investigate whether Li and associates published their study i n the leptin flanking sequence and/or a Diabetes (Linkage and linkage disequilib- larger 40-cM region (7q22.1-7q35) rium mapping of genes influencing human contributes to obesity, we genotyped indi- obesity in chromosome region 7q22.1- viduals from 200 European American 7q35. Diabetes, 2003;52(6):1557- families segregating extreme obesity and 1561). normal weight (1020 subjects) using 2 1 microsatellite markers and two single n u - For more information, contact R. Arlen cleotide polymorphisms (SNPs) and con- Price, Department of Psychiatry, Uni- ducted nonparametric linkage (NPL) versity of Pennsylvania, Center for Neu- analyses." robiology and Behavior, One Clinical Re- search Building, Room 105, 415 Curie "We also carried out transmission dise- Boulevard, Philadelphia, PA 19104, USA. quilibrium tests for 135 European E-mail: [email protected]. American triads using 27 markers (in- cluding eight SNPs)," reported Wei-Dong Publisher contact information for the Li and collaborators at the University of journal Diabetes is: The American Diabetes Pennsylvania, Yale University, and Association, 1701 North Beauregard Michigan Technological University. Street, Alexandria, VA 22311-1717, "Both quantitative (MERLIN-regress) and USA. qualitative (GENE-HUNTER and MERLIN- npl) analyses provided evidence for link- The information in this article comes u n - age for BMI (GENEHUNTER NPL=2.98, 2 0 der the major subject areas of Obesity cM centromeric to leptin at the marker Genomics and Genetics, Obesity Risk Fac- D7S692; MERLIN Z score=3.56). Results tor, and Mutagenesis. for several other regions in 7q gave weak linkage. Transmission disequilibrium test This article was prepared by Obesity, (TDT) and quantitative TDT (and quantita- Fitness & Wellness Week editors from tive pedigree disequilibrium test) analy- staff and other reports. ses suggest linkage disequilibrium near leptin and other regions of 7q." http://www.NewsRx.net CompetitivEdge 1-888-881-EDGE www.clipresearch.com Electronic Clipping Genomics & Genetics Weekly August 1, 2003 EDITOR'S CHOICE; Pg. 7 OBESITY GENOMICS AND GENETICS: Genes influencing human obesity found in chromosome region 7q22.1-7q35 Genes influencing human obesity were "Our results suggested that there could be found in chromosome region 7q22.1- two or more genes in chromosome region 7q35. 7q22.1-7q35 that influence obesity," concluded Li and coauthors. "A new region According to a study from the United found by this study (D7S692-D7S523, States, "Linkage results suggest that the 7q31.1) has the most consistent linkage region of chromosome 7 containing the results and could harbor obesity-related leptin gene cosegregates with extreme genes." obesity; however, leptin coding region mutations are rare. To investigate whether Li and associates published their study i n the leptin flanking sequence and/or a Diabetes (Linkage and linkage disequilib- larger 40-cM region (7q22.1-7q35) rium mapping of genes influencing human contributes to obesity, we genotyped indi- obesity in chromosome region 7q22.1- viduals from 200 European American 7q35. Diabetes, 2003;52(6):1557- families segregating extreme obesity and 1561). normal weight (1020 subjects) using 2 1 microsatellite markers and two single n u - For more information, contact R. Arlen cleotide polymorphisms (SNPs) and con- Price, Department of Psychiatry, Uni- ducted nonparametric linkage (NPL) versity of Pennsylvania, Center for Neu- analyses." robiology and Behavior, One Clinical Re- search Building, Room 105, 415 Curie "We also carried out transmission dise- Boulevard, Philadelphia, PA 19104, USA. quilibrium tests for 135 European E-mail: [email protected]. American triads using 27 markers (in- cluding eight SNPs)," reported Wei-Dong Publisher contact information for the Li and collaborators at the University of journal Diabetes is: The American Diabetes Pennsylvania, Yale University, and Association, 1701 North Beauregard Michigan Technological University. Street, Alexandria, VA 22311-1717, "Both quantitative (MERLIN-regress) and USA. qualitative (GENE-HUNTER and MERLIN- npl) analyses provided evidence for link- The information in this article comes u n - age for BMI (GENEHUNTER NPL=2.98, 2 0 der the major subject areas of Obesity cM centromeric to leptin at the marker Genomics and Genetics, Obesity Risk Fac- D7S692; MERLIN Z score=3.56). Results tor, and Mutagenesis. for several other regions in 7q gave weak linkage. Transmission disequilibrium test This article was prepared by Genomics & (TDT) and quantitative TDT (and quantita- Genetics Weekly editors from staff and tive pedigree disequilibrium test) analy- other reports. ses suggest linkage disequilibrium near leptin and other regions of 7q." http://www.NewsRx.net CompetitivEdge 1-888-881-EDGE www.clipresearch.com Electronic Clipping Biotech Week July 30, 2003 EXPANDED REPORTING; Pg. 327 UNIVERSITY OF PENNSYLVANIA: Genes influencing human obe- sity found in chromosome region 7q22.1-7q35 Genes influencing human obesity were found in chromosome region 7q22.1- "Our results suggested that there could be 7q35. two or more genes in chromosome region 7q22.1-7q35 that influence obesity," According to a study from the United concluded Li and coauthors. "A new region States, "Linkage results suggest that the found by this study (D7S692-D7S523, region of chromosome 7 containing the 7q31.1) has the most consistent linkage leptin gene cosegregates with extreme results and could harbor obesity-related obesity; however, leptin coding region genes." mutations are rare. To investigate whether the leptin flanking sequence and/or a Li and associates published their study i n larger 40-cM region (7q22.1-7q35) Diabetes (Linkage and linkage disequilib- contributes to obesity, we genotyped indi- rium mapping of genes influencing human viduals from 200 European American obesity in chromosome region 7q22.1- families segregating extreme obesity and 7q35. Diabetes, 2003;52(6):1557- normal weight (1020 subjects) using 2 1 1561). microsatellite markers and two single n u - cleotide polymorphisms (SNPs) and con- For more information, contact R. Arlen ducted nonparametric linkage (NPL) Price, Department of Psychiatry, Uni- analyses." versity of Pennsylvania, Center for Neu- robiology and Behavior, One Clinical Re- "We also carried out transmission dise- search Building, Room 105, 415 Curie quilibrium tests for 135 European Boulevard, Philadelphia, PA 19104, USA. American triads using 27 markers (in- E-mail: [email protected]. cluding eight SNPs)," reported Wei-Dong Li and collaborators at the University of Publisher contact information for the Pennsylvania, Yale University, and journal Diabetes is: The American Diabetes Michigan Technological University. Association, 1701 North Beauregard "Both quantitative (MERLIN-regress) and Street, Alexandria, VA 22311-1717, qualitative (GENE-HUNTER and MERLIN- USA. npl) analyses provided evidence for link- age for BMI (GENEHUNTER NPL=2.98, 2 0 The information in this article comes u n - cM centromeric to leptin at the marker der the major subject areas of Obesity D7S692; MERLIN Z score=3.56). Results Genomics and Genetics, Obesity Risk Fac- for several other regions in 7q gave weak tor, and Mutagenesis. linkage. Transmission disequilibrium test (TDT) and quantitative TDT (and quantita- This article was prepared by Biotech Week tive pedigree disequilibrium test) analy- editors from staff and other reports. ses suggest linkage disequilibrium near leptin and other regions of 7q." http://www.NewsRx.net CompetitivEdge 1-888-881-EDGE www.clipresearch.com Electronic Clipping USA TODAY July 30, 2003, Wednesday, FINAL EDITION LIFE; Pg. 4D Students face swapping rules Jefferson Graham Robinson sits on an educators gitimate alternatives such as committee the RIAA formed to try Pressplay and MusicNet have When students arrive in New Ha- and tackle the growing problems fewer than 300,000 combined. ven, Conn., next month for their of piracy -- serious worldwide but freshman orientation at Yale, worst on campus, where music- "The numbers are too enormous they'll hear about more than aca- loving students move from slow for this kind of tactic to have any demics and campus life. home hookups to speedy cam- kind of immediate effect," says pus networks capable of down- University of Southern California After four college students were loading songs in seconds. professor Douglas Thomas, who sued last spring by the record teaches about technology and industry for online song swapping "I liken it to going from a bubble- media issues. and a flurry of subpoenas re- gum machine to a fully stocked cently sent to universities and candy store," says Sheldon Ste- Graham Spanier, president of