MINISTRY OF PUBLIC HEALTH OF UKRAINE

Department of human resources policy, education and science

Testing Board

Student ID Last name

Variant ______

Test items for licensing examination

Krok 1

PHARMACY

(російськомовний варіант)

General Instruction

Every one of these numbered questions or unfinished statements in this chapter corresponds to answers or statements endings. Choose the

answer (finished statements) that fits best and fill in the circle with the corresponding Latin letter on the answer sheet.

Authors of items: Abramov A.V., Aleksandrova K.V., Andronov D.Yu., Bilyk O.V., Blinder O.O., Bobyr V.V., Bobrovska O.A., Bohatyriova O.V., Bodnarchuk O.V., Boieva S.S., Bolokhovska T.O., Bondarenko Yu.I., Bratenko M.K., Buchko O.V., Cherneha H.V., Davydova N.V., Deriuhina L.I., Didenko N.O., Dmytriv A.M., Doroshkevych I.O., Dutka N.M., Dynnyk K.V., Filipova L.O., Havryliuk I.M., Herhel T.M., Hlushkova O.M., Hozhdzinsky S.M., Hrekova T.A., Hrechana O.V., Hruzevsky O.A., Hudyvok Ya.S., Hurmak I.S., Ivanets L.M., Ivanov Ye.I., Kartashova T.V., Kava T.V., Kazakova V.V., Kazmirchuk H.V., Kernychna I.Z., Khlus K.M., Khmelnykova L.I., Klebansky Ye.O., Klopotsky H.A., Klymniuk S.I., Kobylinska L.I., Koldunov V.V., Kolesnyk V.P., Kolesnikova T.O., Komlevoy O.M., Kononenko N.M., Kornijevsky Yu.Y., Kremenska L.V., Krushynska T.Yu., Kryzhanovska A.V., Kryshtal M.V., Kukurychkin Ye.R., Kuznietsova N.L., Kuzmina A.V., Lisnycha A.M., Lychko V.H., Makats Ye.F., Maly V.V., Matvijenko A.H., Menchuk K.M., Minarchenko V.M., Mikheiev A.O., Mishchenko K.M., Monatko K.V., Mruh V.M., Mylnikova O.O., Mykhailova I.V., Naida L.Ya., Nikitin O.V., Nikitina O.O., Novobranova O.V., Nykytiuk H.P., Osipenko L.K., Osiychuk O.V., Podpletnia O.A., Potikha N.Ya., Pyda V.P., Reva T.D., Rohovy Yu.Ye., Rohovyk V.Y., Romanenko M.I., Rotar D.V., Rovinsky O.O., Ryzhenko I.M., Sahaidak Ye.V., Salata O.V., Savustianenko A.V., Savchenko L.H., Seniutovych N.R., Sidelnikova T.A., Sira L.M., Skliarov O.Ya., Smoliakova H.N., Stetskiv A.O., Stoletov Yu.B, Streltsova N.Yu., Strilets L.M., Struchaieva H.I., Strumenska O.M., Surova N.A., Sviechnikova O.M., Sydorenko O.L., Tashchuk K.H., Tiupka T.I., Tokaryk H.V., Trzhetsynsky S.D., Tvorko M.S., Ulizko I.V., Usynsky R.S., Varynsky B.O., Vasiuk S.O., Vasylieva A.H., Vedernykova I.O., Vlasenko O.V., Vronska L.V., Shatova O.P., Shemonaieva K.F., Sheveliova N.Yu., Shevtsova A.I., Shkoda O.S., Shono N.A., Shtryhol S.Yu., Shumeiko O.V., Shvets V.M., Shyrykalova A.O., Yahupova A.S., Yaremiy I.M., Yashchyshyn Z.M., Yushchenko T.I., Zadorina O.V., Zahrychuk H.Ya., Zarechensky M.A., Zhylinska K.I. and Committees of professional expertise.

Item reviewers. Anisimova V.YU., Arzumanov P.S., Bocharov O.A., Cherpak O.M., Deineka C.YE., Herush O.V., Holdobina O.V., Hontova T.M., Hrihor’yeva N.P., Ivanec L.M., Kaluhina S.M., Kaplaushenko A.H., Klepa T.I., Kobilinska L.I., Kostina T.A., Lisnicha A.M., Lyubinec L.A., Macoid O.B., Minarchenko V.M., Ohurcov V.V., Pocrishko O.V., Shanaida M.I., Shtrihol S.YU., Томаrovska Т.О., Tyupka Т.І., Vasuk S.O., Vronska L.V., Yuschenko Т.І., Zahaiko A.L., Zahrichuk H.YA.,

The book includes test items for use at licensing integrated examination “Krok 1. Pharmacy” and further use in teaching.

The book has been developed for students of pharmaceutical faculties and academic staff of higher medical educational establishments.

Approved by Ministry of Public Health of Ukraine as examination and teaching publication based on expert conclusions (Orders of MPH of Ukraine of 14.08.1998 №251, of 27.12.1999 №303, of 16.10.2002 №374, of 29.05.2003 №233).

© Copyright Testing Board. Krok 1 Pharmacy 2015 1

1. Calculation of thermal effects of below are all of the same molarity, the hi- chemical reactions at pharmaceutical ghest boiling temperature will belong to: production is based on the Hess law stati- ng, that reaction thermal effect is determi- A. Sodium sulfate ned by: B. Promedol (Trimeperidine) C. Nicotinamide A. Initial and final state of system D. Resorcin B. Mechanism by which the chemical E. Iodine change occurs C. Route by which the chemical change 7. Which of these formulas corresponds wi- occurs th acetoacetic acid? D. Number of intermediate stages E. Process duration A. 2. A victim of a traffic accident is hospi- talized at a resuscitation unit. Objectively: the patient is unconscious, BP is 90/60 mm Hg, high blood content of creatinine and B. urea is observed, diurnal diuresis is 80 ml. Characterize the patient’s diurnal diuresis: C. A. Anuria B. Oliguria C. Polyuria D. Pollakiuria D. E. Nocturia 3. In snake venom there is a substance that causes erythrocyte hemolysis when E. it is introduced into a human organi- sm. Blood test revealed a large amount 8. Universal system of biological oxidati- of lysolecithin (lysophosphatidylcholi- on of nonpolar compounds (numerous ne). What enzyme leads to accumulating drugs, toxic agents, steroid hormones, lysolecithin in blood? cholesterol) is microsomal oxidation. A. Phospholipase A2 Name the cytochrome that is included in B. Phospholipase A1 oxygenase chain of microsomes: C. Phospholipase C A. Cytochrome Р-450 D. Phospholipase D B. Cytochrome C E. Neuraminidase C. Cytochrome A3 4. Microbe survial in environment is faci- D. Cytochrome A litated by spore formation. What mi- E. Cytochrome C1 croorganisms of those listed below are 9. A patient with chronic constipation had spore formers: been prescribed bisacodyl. After 3 weeks A. Clostridium of treatment, the patient noticed a reducti- B. Bacteroides on of laxative effect. This is caused by the C. Staphylococcus development of the following side-effect: D. Peptococcus A. To l e r a n c e E. Peptostreptococcus B. Dependence 5. Bacteria rapidly become resistant C. Sensibilization to drugs in the course of antibacterial D. Cumulation treatment. What structural components of E. Dysbacteriosis bacteria provide for their resistance? 10. A newborn child born from Rh- A. R-plasmids negative mother in the result of her thi- B. Spores rd pregnancy presents with gradually C. Capsule worsening jaundice, irritated central D. Flagella nervous system, anemia. What type of E. Volutine granules jaundice does the infant suffer from? 6. If aqueous solutions of the drugs listed Krok 1 Pharmacy 2015 2

A. Hemolytic A. Open, heterogeneous B. Hepatocellular B. Isolated, heterogeneous C. Obstructive C. Closed, homogeneous D. Parasitic D. Closed, heterogeneous E. To x i c E. Open, homogeneous 11. Structure of proteins includes protei- 16. What drug should be administered for nogenic amino acids. What is the position individual prevention of malaria? of the amino group in the structure of these amino acids? A. Chingamin B. Rifampicin A. α-position C. Ampicillin B. β-position D. Gentamicin C. γ-position E. Biseptol (Co-Trimoxazolel) D. δ-position E. -position 17. A sample section of an axial body shows a complex consisting of phellogen and its 12. In an emergency situation a scuba di- derivatives - cork and phelloderm. This ti- ver has quickly risen from the depths to ssue is called: the surface, thus breaking safety rules. He is unconscious, presents with respiratory A. Periderm failure and cardiac activity disorder as the B. Colenchyma result of decompression sickness. What C. Sclerenchyma complication may develop in the scuba di- D. Epiblema ver? E. Epidermis A. Gas embolism 18. When root was being studied under mi- B. Fat embolism croscope, root hairs were detected, which C. Air embolism are cell growths of: D. Cellular embolism E. Thromboembolism A. Epiblema B. Epidermis 13. The patient has been hospitalised with C. Endoderm pneumonia. What kind of respiratory fai- D. Exoderm lure does the patient have? E. Mesoderm A. Restrictive 19. The Mohr method is used to determi- B. Obstructive ne sodium chloride mass concentration in C. Central isotonic solution. Titration is carried out D. Peripheral with the following indicator present: E. Thoracic diaphragm A. Potassium chromate 14. Thermodynamic calculations allow B. Fluorescein us to determine the possibility and di- C. Ammonium iron (III) sulfate rection of spontaneous processes. In an D. Diphenylcarbazone isolated system the change of the followi- E. Ferroin ng thermodynamic function is used for this purpose: 20. Choose the pair of electrodes for potentiometric pH measurement of a A. Entropy solution: B. Gibbs energy C. Helmholtz energy A. Glass and silver chloride D. Internal energy B. Calomel and silver chloride E. Enthalpy C. Quinhydrone and antimonial D. Mercury sulphate and silver chloride 15. Organisms of plants and animals E. Glass and antimonial belong to biological systems that perform substance and energy exchange with their 21. What disorder of local circulation is environment. These systems are: characterized by pallor, local temperature drop, pain, local sensitivity disorder, reduction of the organ volume? Krok 1 Pharmacy 2015 3

A. Ischemia Ba2+) the solubility of sulphates can be B. Venostasis reduced by adding: C. Thrombosis D. Embolism A. Ethyl alcohol E. Arterial hyperemia B. Distilled water C. Benzene 22. Racemose clusters of calcium D. Chloroform carbonate crystals are detected among E. Amyl alcohol the waste products of a protoplast. These crystals are: 28. In a surgical unit an outbreak of purulent infections has been regi- A. Cystoliths stered. The infections are caused by B. Isolated crystals Staphylococcus aureus with multiple resi- C. Raphides stance to antibiotics. What plasmid has D. Styloids provided this property? E. Druses A. R 23. Heartrateofapersonatrestis40/min. B. F What structure is the pacemaker of heart C. Col in this man? D. Tox E. Hly A. Atrioventricular node B. Sinoatrial node 29. What standard solution (titrant) is used C. His’ bundle in Folgard’s direct titration method? D. His’ bundle branches E. Purkinje fibers A. Ammonium thiocyanate B. Sodium chloride 24. The volume of air exhaled by a C. Silver nitrate healthy person during quiet breathing was D. Potassium chromate measured with a spirometer and determi- E. Potassium dichromate ned to be 0,5 liter. What is this volume called? 30. Uric acid is a derivative of: A. Tidal volume B. Inspiratory reserve volume C. Expiratory reserve volume D. Vital capacity of lungs E. Residual volume 25. A patient has been taking diclofenac A. Purine sodium for a long time. A family physi- B. Indole cian withdrew this drug and prescribed C. Pyrazine celecoxib. What disease was the cause of D. Pyrazole drug substitution? E. Pyridine A. Peptic ulcer 31. Select structural isomers among the gi- B. Bronchial asthma ven compound pairs: C. Urolithiasis D. Arterial hypertension E. Chronic hepatitis 26. Specify the standard solution (titrant) for the iodometric determination of oxi- dants:

A. Na2S2O3 B. KMnO4 C. I2 D. K2Cr2O7 E. KBrO3 27. In the qualitative analysis which involves precipitation of sulphates of the third analytical group cations (Ca2+, Sr2+, Krok 1 Pharmacy 2015 4

36. In terms of water-air interface, the following substance acts as a surface-active A. substance: A. Va l e r i c a ci d B. HCl C. NaOH B. D. Urea E. - 37. At the sixth month of pregnancy a woman has been diagnosed with C. severe iron-deficiency anemia. Diagnostic character was the appearance of the following in blood: D. A. Hypochromic erythrocytes B. Macrocytes C. Megalocytes E. D. Reticulocytes E. Erythroblasts 32. Optical activity of monosaccharides 38. Nitrite ions in presence of nitrate ions can be explained by their: can be detected by means of: A. Asymmetric carbon atoms in a molecule A. Crystalline antipyrine in presence of B. Asymmetric crystal dilute HCl C. Complicated rotation around σ-bond B. Crystalline sodium thiosulfate D. Aldehyde or ketone group C. Dimethylglyoxime E. Number of hydroxyl groups in a D. Crystalline iron (III) sulfate molecule E. Diphenylcarbazone 33. Name the disaccharide with the 39. Choose the colloid surfactant among following structure: the substances listed below: A. Potassium oleate B. Iodine C. Sodium chloride D. Polyethylene E. Gelatin 40. Analysis of the cerebrospinal fluid of A. β-lactose a child with signs of purulent lesion of B. α-lactose brain tunics revealed gram-negative bean- C. β-maltose shaped diplococci. What provisional di- D. β-cellobiose agnosis can be made on the basis of the E. Saccharose analysis results? 34. Which of the ligands is bidentate? A. Meningitis B. Gonorrhea A. Ethylenediamine C. Cholera B. Thiocyanate ion D. Plague C. Cyanide ion E. Anthrax D. Pyridine E. Hydroxide ion 41. Given the ability of iodine to dissolve in nonpolar solvents, determine the type 35. Combined administration of furosemi- of chemical bond in an I molecule: de with aminoglycoside antibiotics causes: 2 A. Nonpolar covalent A. Hearing impairment B. Ionic B. Increased blood pressure C. Polar covalent C. Cramps D. Metal D. Hyperhidrosis E. Intermolecular interaction E. Increased intraocular pressure 42. What product results from propionic Krok 1 Pharmacy 2015 5 aldehyde and PCl5 interaction? an infectious patient with penicillin, the pathogen transformed into the L-form. What changes occur in the pathogen cell in case of L-transformation? A. Absence of a cell wall B. Absence of flagella A. C. Absence of a capsule D. Absence of a spore E. Absence of inclusions 45. Interaction of aniline with bromine B. water resulted in white precipitate. What substance was produced?

C.

D. A.

E. B.

43. Which of these reactions can be used to identify the primary amino group? C.

A. D.

B. E.

46. During feces analysis of a 3-month- old child with signs of enteric infection, numerous dark-red colonies has grown on Endo agar. What microorganisms can be C. the cause of such enteric infection? A. Escherichia B. Streptococci C. Gonococci D. D. Salmonellae E. Shigella 47. During assessment of air purity in an aseptic unit of a phamacy, sedimentation analysis had been applied. Test resulted E. in growth of the small colonies with areas of hemolysis. What medium was used for inoculation? 44. In the course of long-term treatment of Krok 1 Pharmacy 2015 6

A. Blood agar A. Vitamin PP B. Levine’s formulation (Eosin Methylene B. Vitamin C Blue agar) C. Vitamin A C. Endo agar D. Vitamin B1 D. Ploskirev’s agar E. Vitamin D E. Egg-yolk salt agar 54. After application of chlorine-zinc- 48. What enzyme allows for synthesys iodine to the thick colourless cell of various genes from template-RNA to membranes of collenchyme they became DNA in genetic engineering (this enzyme violet. That means the membranes are: catalyzes the process detected in RNA- A. Cellulose viruses)? B. Lignificated A. Reverse transcriptase C. Cutinized B. Exonuclease D. Mineralized C. DNA-ligase E. Suberinized D. Helicase 55. Calomel electrode is listed in the State E. Endonuclease Pharmacopoeia of Ukraine as auxiliary 49. According to van’t Hoff rule, when the electrode for pH measurement. What type temperature is raised by 10 degrees, the of electrodes is it? reaction rate increases by: A. Second kind A. 2-4 times B. First kind B. 1,5 times C. Gas C. 5times D. Redox D. 10 times E. Ion-selective E. Temperature does not affect reaction rate 56. Specify the name of the compound 50. What anions form brown ring with iron according to the IUPAC nomenclature: (II) salts in the presence of concentrated sulfuric acid? A. Nitrate ions B. Acetate ions C. Bromate ions D. Citrate ions E. Thiocyanate ions A. 2,3,5-Trimethyl heptadiene-3,4 51. Specify the precipitating agent to be B. 3,5,6,6-Tetramethyl heptadiene-3,4 used in gravimetric determination of calci- C. 3,5,6,6-Trimethyl hepten-3 um salts: D. 2-Ethyl-4,5-dimethyl hexadiene-2,3 E. 2-Ethyl-4,5,5-trimethyl pentadiene-2,3 A. (NH4)2C2O4 B. K2C2O4 57. Thiocyanatometric titration method C. Na2C2O4 requires secondary standard solution of D. Na2CO3 potassium thiocyanate that is standardized E. K2CO3 with standard solution of: 52. Chromatin contains positively charged A. Silver nitrate histone proteins. What amino acid is B. Hydrochloric acid contained in histone proteins in large C. Sulfuric acid amounts? D. Iron (II) sulfate E. Copper (II) nitrate A. Lysine B. Alanine 58. Toidentifyadrugbythin-layer C. Valine chromatography the following parameter D. Threonine is used: E. Serine 53. Diet of a human must contain vitami- ns. What vitamin is usually prescribed for treatment and prevention of pellagra? Krok 1 Pharmacy 2015 7

A. Rf A. Autoimmune disorder of the nephron B. n glomerulus C. E, mV B. Inflammatory disorder of the nephron D. I, A tubule E. Kp C. Ishemic disorder of the nephron tubule D. Increased concentration of blood protei- 59. A 22-year-old man was stung by bees; ns the affected area became hyperemic and E. Disorder of the urinary tracts edematous. What is the leading mechani- sm of edema development in this patient? 64. To determine sodium iodide with Fajans method the following indicator is A. Increased permeability of the capillaries required: B. Decreased hydrostatic blood pressure in the capillaries A. Eosin C. Increased oncotic pressure of tissue fluid B. Methyl-orange D. Impaired lymphatic efflux C. Diphenylcarbazone E. Reduced oncotic pressure of blood D. Potassium chromate E. Iron ammonium alum 60. A patient has obstruction of the common bile duct. Which of these 65. Which of the given compounds WILL substances is usually found in urine in such NOT decolorize bromine water? cases? A. CH3 − CH3 A. Bilirubin B. CH2 = CH2 B. Ketone bodies C. CH ≡ CH C. Uric acid D. CH3 − CH = CH2 D. Creatinine E. E. Glucose 61. A student analyzes an axial plant organ characterized by radial symmetry, unlimited growth, positive geotropism. It provides nutrition, vegetative propagation, 66. Which of the following reactions is anchorage of plant in the soil. This organ required in order to obtain an azo dye out can be identified as: of an aromatic amine? A. Root A. Diazotization and azo compound B. Stem B. Reduction and diazotization C. Leaf C. Diazotization and interaction with D. Rhizome potassium cyanide E. Seed D. Salt formation and nitration E. Alkylation and nitrosation 62. Choose the name that corresponds wi- th the formula: CH3 − C ≡ N: 67. What is the mechanism of bromination of toluene methyl group? A. Acetic acid nitrile B. Acetamide C. Acetic anhydryde D. Acetoxime E. Ethyl isocyanide

63. A patient with systemic lupus A. SR erythematosus has developed diffuse B. AE affection of kidneys followed by protei- C. SE nuria, hypoproteinemia, extensive swelli- D. SN ng. What mechanism of proteinuria E. AN development is the most likely in this case? 68. Quinoline reacts with the following reagent if heteroatom is present: Krok 1 Pharmacy 2015 8

A. Radicle A. B. Apical meristem C. Pericycle B. Na2SO4 D. Lateral meristem

E. Intercalary meristem  C.
D. NaNH2 E. NaNO 74. Silver mirror reaction can be 3 characterized by: 69. Aniline can be converted into the water-soluble salt through its treatment wi- A. Production of metal th the solution of: B. Smell C. Red colouring of precipitate A. Hydrochloric acid D. Blue colouring of solution B. Sodium hydroxide E. Decolouration C. Sodium sulfate D. Ethanol 75. The end product of starch hydrolysis is: E. Dimethylamine A. D-glucose 70. Specify the reagent necessary for the B. D-fructose following transformation: C. Saccharose D. Maltose E. D-galactose 76. Specify the electronic effects of the carboxylic group (-СООН) in a benzoic acid molecule: A. NH2NH2 B. NH2OH A. -I, -M C. CH3NH2 B. -I D. C6H5NHNH2 C. +I, -M E. NH3 D. +I E. -I, +M 71. One of the cyclic glucose forms is as follows: 77. Which of the alcohols given below produces acetone when oxidated?

Name this compound:

A. α-D-glucopyranose A. B. β-D-glucopyranose C. α-L-glucopyranose D. α-D-glucofuranose B. E. β-D-glucofuranose 72. Select the formula for pentene-2 from C. the list: D. A. CH3 − CH2 − CH = CH − CH3 − − − − B. CH3 CH2 CH2 CH2 CH3 E. C. CH3 − CH2 − CH2 − CH = CH2 D. CH3 − CH2 − CH2 − CH3 − − E. CH3 CH = CH CH3 78. What reagent allows to simultaneously detect both aldehyde group and glycol 73. The study of the main root ontogenesis fragment presence in glucose molecule? shows that it has developed from: A. Cu(OH)2 B. Br2 C. AlCl3 D. FeCl3 E. KMnO4 Krok 1 Pharmacy 2015 9

79. What class of organic compounds is A. 3’,5’-phosphodiester characterized by the presence of C ≡ N B. Peptide group? C. Glycosidic D. Disulfide A. Nitriles E. Amide B. Amines C. Nitro compounds 85. Quercus robur leaves have the followi- D. Alcohols ng type of lamina shape and division: E. Aldehydes A. Pinnatilobate 80. If the amount of a high-molecular B. Trilobate substance added to the sol is very small, C. Pinnatipartite it may not increase but decrease its stabili- D. Palmatilobate ty. This phenomenon is called: E. Palmatipartite A. Sensibilization 86. Microbiological purity of tableted B. Solubilization drugs had been tested at a factory. Samples C. Mutual coagulation cultivation in mannitol salt agar resulted D. Colloidal protection in growth of golden-yellow colonies, mi- E. Sol adaptation croscopic examination of colonies detected gram-positive globular bacteria situated 81. Spore and pollen analysis revealed in clusters; microorganisms had plasma tetrahedral spores in the pollen, whi- coagulation prorerties. What pure bacteri- ch have semi-circular base and reticular al culture was obtained? surface. The spores can belong to: A. Staphylococcus aureus A. Lycopodiophyta B. Enterobacteriaceae B. Equisetiphyta C. Staphylococcus epidermidis C. Bryophyta D. Staphylococcus saprophyticus D. Polypodiophyta E. Pseudomonas aeruginosa E. Pinophyta 87. Leaves affected by mosaic discoloration 82. In the practice of harvesting herbal have been detected at medicinal plantati- raw material of Asteraceae family the term ons. What microorganisms are the cause? ”flowers” means both individual flowers and inflorescences. However, the notion of A. Plant-pathogenic viruses ”flowers” is botanically correct only for: B. Plant-pathogenic bacteria C. Plant-pathogenic fungi A. Centaurea cyanus D. Protozoa B. Gnaphalium uliginosum E. Rickettsia C. Arnica montana D. Echinops ritro 88. A dry-heat box is used for sterilization E. Bidens tripartita of various materials and instruments in a bacteriological laboratory. This sterilizati- 83. A woman noticed that a cut on her on method can be applied to the following skin was still bleeding even after 20 mi- objects: nutes had passed. What vitamin deficiency causes such condition? A. Glass test tubes B. Rubber gloves A. Vitamin K C. Simple nutrient medium B. Vitamin A D. Wire inoculating loops C. Vitamin D E. Physiological solution D. Vitamin E E. Vitamin B12 89. A 3,5-year-old child has been di- agnosed with dysbacteriosis in the form 84. The primary structure of nucleic acids of critical reduction of gram-positive is a polynucleotide chain that has a certain anaerobic bacteria and increased number composition and order of the nucleotides. of staphylococci and yeast fungi. What What bonds stabilize this structure? preparation should be used for the correction of dysbacteriosis? Krok 1 Pharmacy 2015 10

A. Bifidumbacterin A. Lactase B. Colibacterin B. Maltase C. Coli-Proteus bacteriophage C. Aldolase D. Furazolidone D. Hexokinase E. Lactoglobulin E. Glycosidase 90. A sample of water used in drug 95. A man presents with signs of albi- production has been sent to a laboratory nism: blonde hair, extreme photosensi- for sanitary and virological analysis. tivity, impaired vision. What amino acid Presence of what virus group will be indi- metabolism is disrupted in the patient? cative of faecal contamination of water and thus the need for its additional purificati- A. Ty r o s i n e on? B. Methionine C. Proline A. Picornaviridae D. Histidine B. Herpesviridae E. Valine C. Orthomyxoviridae D. Retroviridae 96. In the process of silver cations identi- E. Flaviviridae fication reaction HCl and then ammonia solution have been added to the solution. 91. Specify the indicator of the protective What compound has been produced as a properties of high-molecular compounds result?

of body, which promote the retention of

 

calcium, phosphate and carbonate in blood A. [üg(N 3)2] l

 

plasma: B. [üg2(N 3)3] l 

C. üg 

A. Protective value D. üg l

  B. Coagulation threshold E. [üg(N 3)3] l C. Critical micelle concentration D. Hydrophilic-lipophilic balance 97. Microscopic study of soybean seeds E. Volume of sol coagulated by 1 mol of the stained with Sudan III revealed droplets electrolyte substance of various sizes. They are: 92. A 40-year-old man diagnosed with A. Lipids gastric ulcer has developed the symptoms B. Proteins anew after a long period of dormancy. Such C. Starch disease course can be characterized as a: D. Inulin E. Glycogen A. Recurrence B. Remission 98. In a chemico-analytical laboratory a di- C. Recovery spensing chemist studies the solution of D. Latency anion mixture. When antipyrin solution is E. Prodromal phase added to the solution, it becomes emerald- green in colour. This analytical effect signi- 93. An elderly patient exhibits low levels of fies presence of the following anions: red blood cells and hemoglobin in blood, but the color index is 1,3. Blood smear A. Nitrite analysis revealed megaloblasts. What type B. Nitrate of anemia is observed in this case? C. Acetate D. Ta r t r a t e A. B12-folic acid deficiency E. Citrate B. Iron-deficiency C. Acquired hemolytic 99. Selective solvents are used in D. Hereditary hemolytic laboratories and factories to isolate and E. Chronic posthemorrhagic refine essential oils, alkaloids, antibiotics and other pharmaceutical subctances. This 94. After drinking milk a 1-year-old child process is called: has developed diarrhea and flatulence. The baby is likely to have the deficiency of the A. Extraction following enzyme: B. Sedimentation C. Coagulation D. Flocculation E. Flotation 100. Sol of iron (III) hydroxide is positi- Krok 1 Pharmacy 2015 11 vely charged. Specify the ion which has the A. Rimantadine lowest coagulation threshold: B. Metisazone C. Levamisole 2− A. SO4 D. Azidothimidine B. Cl− E. Acyclovir C. Cu2+ D. Na+ 106. Colloid silver preparations E. J − Protargolum and Collargolum are widely used in medical practice as bactericidal 101. Specify the standard solutions that are drugs. In addition to the active ingredients, used in permanganatometric titration to these drugs contain protein compounds. quantify the oxidants by the residual ti- What is the function of proteins in these tration method: preparations? A. Potassium permanganate, iron (II) A. Prevention of coagulation of the colloi- sulfate dal solution B. Potassium dichromate, sodium thi- B. Prolongation of shelf-life osulfate C. Reduction of the side effects C. Potassium bromate, sodium thiosulfate D. Improvement of the drug technology D. Potassium iodate, sodium thiosulfate E. Potentiation of the bactericidal action of E. Cerium (IV) sulfate, iron (II) sulfate silver 102. What indicator is used for fixing the 107. Mass fraction of Fe2+ ions in Mohr’s endpoint of mercurimetric titration? saltcanbedeterminedbygravimetricsedi- mentation method using: A. Thiocyanate complexes of iron (III) B. Fluorescein A. NH4OH C. Eosin B. Na2S D. Murexide C. K3PO4 E. Potassium chromate D. BaCl2 E. ZnCl2 103. Substrate-linked phosphorylation occurs in the cycle of tricarboxylic acids. 108. Silver nitrate solution has been added What compound takes part in this reacti- to the solution containing anions of the fi- on? rst analytical group. It resulted in yellow precipitate. That means the following are A. Succinyl coenzyme A present in the solution: B. α-ketoglutarate C. Acetyl coenzyme A A. Arsenite ions D. Succinate B. Arsenate ions E. Malate C. Sulphate ions D. Iodide ions 104. The patient with alcoholic ci- E. Bromide ions rrhosis complains of general weakness and dyspnea. The following is revealed: 109. Inhibition of the synthesis of bile aci- decrease of arterial pressure, ascites, di- ds from cholesterol in liver of an experi- lation of the superficial veins of the mental animals has caused maldigestion of stomach anterior wall, esophageal vari- lipids. What is the role of these acids in the cose veins dilatation, splenomegaly. What enteral lipidic metabolism? haemodynamics disorder does the patient suffer from? A. They emulsify dietary lipids B. They keep balance of alkaline envi- A. Portal hypertension ronment in the intestines B. Left ventricular failure C. They participate in the synthesis of lipids C. Right ventricular failure D. They are part of LDL D. Cardiac insufficiency E. They activate the formation of chylomi- E. Collapse crons 105. Pharmacy has received viricides. 110. Name the above-ground sprout modi- Choose the viricide used for influenza fications that develop from lateral buds, treatment from the list given below: are situated in leaf angles or inflorescences, and take part in vegetative reproduction: Krok 1 Pharmacy 2015 12

A. Bulbils allergic reaction. The development of the B. Above-ground tubers allergic reaction is caused by the increased C. Cladodes synthesis of the following compound: D. Tendrils E. Thorns A. Histamine B. Choline 111. What type of conducting bundles is C. Adrenaline characteristic of all root zones in one- D. Histidine seeded plants? E. Serotonin A. Radical 117. The patient has icteric skin; B. Amphivasal (Lepto centric) unconjugated bilirubin content in blood C. Amphicribal (Hadro centric) is high; conjugated bilirubin in urine is not D. Bilateral detected. There is significant amount of E. Collateral urobilin in urine and stercobilin in feces. Name the pathology characterized by the 112. A patient with atherosclerosis has given symptoms: been prescribed Linaetholum containi- ng essential fatty acids. Which of the A. Hemolytic jaundice following acids is an essential part of the B. Obstructive jaundice preparation? C. Jaundice of the newborn D. Hepatocellular jaundice A. Linolenic E. Atherosclerosis B. Palmitic C. Crotonic 118. A patient complains of pain in the D. Stearic small joints. High concentration of uric E. Oleic acid is detected in his blood plasma. What pathology causes such changes? 113. The Volhard method is used to determine sodium chloride mass A. Gout concentration. Name the titrant of this B. Diabetes mellitus method: C. Phenylketonuria D. Lesch-Nyhan syndrome A. Ammonium thiocyanate E. Diabetes insipidus B. Mercury (I) nitrate C. Sodium tetraborate 119. Corolla of a zygomorphic D. Mercury (II) nitrate hermaphroditic flower consists of 5 petals: E. Sodium hydroxide the largest one is called the banner, the two lateral petals are called the wings, and the 114. Mass fraction of pharmaceutical two fused petals forming the keel. Such preparations that contain aromatic ami- corolla is characteristic of medicinal plants no groups is determined through nitrite of Leguminosae family. Name the type of titration. What external indicator is used corolla: in this case? A. Papilionaceous A. Starch-iodide paper B. Labiate B. Methylene red C. Saucer-shaped C. Eriochrome Black T D. Funnelform D. Phenolphthalein E. Tubular E. Eosin 120. What ions have maximal coagulative 115. What cation of the 4th analytical effect, when added into positive sols? group is present in a solution, if it is known 3− that the reaction with a group reagent A. PO4 causes formation of yellow precipitate? B. Al3+; Fe3+ + + 3+ C. K ; Na A. Cr 2− 2+ D. SO4 B. Zn − C. Sn2+ E. Cl 3+ D. Al 121. What anion of the 2nd analytic group E. Sn(IV ) produces black precipitate with group 116. In response to the administration reagent AgNO3? of protein drugs, a patient developed an Krok 1 Pharmacy 2015 13

A. S2− vered into a contagious isolation ward of B. I− a hospital. He is diagnosed with toxic di- C. Cl− phtheria of the pharynx. What drug should D. Br− be administered immediately for specific E. NCS− treatment and prevention of complicati- ons? 122. A patient suffering from coronary heart disease, who had had two myocardial A. Antidiphtheric serum infarctions of left ventricular wall, presents B. Diphtheria and tetanus toxoids and with bubbling breathing and dyspnea. pertussis adsorbed vaccine Pulmonary auscultation reveals numerous C. Diphtheria anatoxin moist crackles. What kind of heart failure D. Penicillin antibiotic is it? E. - A. Left ventricular 128. Cataract (lenticular opacity) has B. Right ventricular developed in a 52-year-old woman wi- C. Compensated th pancreatic diabetes. What process has D. Subcompensated intensified and thus caused lenticular E. Combined opacity? 123. You are studying the silvery downy A. Protein glycosylation plant of Asteraceae family, which is rich wi- B. Lipolysis th essential oils and bitters. Harvested are C. Ketogenesis apical sprouts with panicle of small round D. Protein proteolysis flower heads. This plant is: E. Gluconeogenesis A. Artemisia absinthium 129. Common nettle, hop, black elderberry B. Arctium lappa are the plants that require soils rich in ni- C. Bidens tripartita trogen compounds, that is, such plants are D. Calendula officinalis called: E. Chamomilla recutita A. Nitrophytes 124. A 46-year-old patient was found to B. Nitrophobes have hyperactivity of creatine kinase in his C. Calciphiles blood serum. What kind of pathology can D. Calciphobes be suspected? E. Halophytes A. Myocardial infarction 130. A man received a radiation dose of B. Acute pancreatitis 30 Gy. He presents with necrotic angi- C. Chronic hepatitis na, disorders of the gastrointestinal tract. D. Haemolytic anemia Blood tests revealed anemia, leukopenia E. Renal failure and thrombocytopenia. What period of acute radiation sickness is observed in the 125. Microcrystalloscopic reactions of patient? potassium ions detection include the reaction with: A. Height of disease B. Primary reactions A. Sodium lead hexanitrocuprate (II) C. Imaginary wellbeing B. Sodium hydrotartrate D. End of disease C. Sodium hexanitrocobaltate E. - D. Sodium tetraphenylborate E. Flame test 131. In the course of an experiment in the mesenteric vein of a toad a trombus 126. Emulsions containing less then 0,1% was created with a crystal of common salt. of dispersed phase (in volume) are classifi- What processes occurred during the first ed as: stage of trombus formation? A. Diluted A. Adhesion, aggregation, agglutination of B. Concentrated platelets C. High-concentration B. Production of active thromboplastin D. Water-in-oil type C. Production of thrombin E. Oil-in-water type D. Production of fibrin monomer E. Production of fibrin polymer 127. A student in severe condition was deli- Krok 1 Pharmacy 2015 14

132. A patient with hyperproduction ffusion is called: of thyroid hormones has been prescri- bed Merkazolilum. This drug inhibits A. Dialysis the following enzyme of iodothyronine B. Electrodialysis synthesis: C. Ultrafiltration D. Decantation A. Iodide peroxidase E. Compensatory dialysis B. Aromatase C. Reductase 138. Neuroleptanalgesia has been appli- D. Decarboxylase ed in the case of cardiac infarction. What E. Aminotransferase neuroleptic is most often applied along wi- th fentanyl? 133. Hemoglobin catabolism results in release of iron which is transported to the A. Droperidol bone marrow by a certain transfer protein B. Perphenazine (Aethaperazinum) and is used again for the synthesis of C. Levomepromazine hemoglobin. Specify this transfer protein: D. Clozapine E. Sulpiride A. Transferrin (siderophilin) B. Transcobalamin 139. Due to prolonged taking of C. Haptoglobin phenobarbital the epileptic patient has D. Ceruloplasmin developed tolerance for this drug. What E. Albumin is this phenomenon based on? 134. For the specific prevention of A. Biotransformation acceleration influenza the employees of an enterprise B. Absorption process weakening were vaccinated with ”Influvac”.Whattype C. Increase of receptor sensitivity of immunity will develop in the body of D. Biotransformation suppression those vaccinated? E. Substance accumulation in body A. Artificial active 140. What side effect is characteristic of B. Innate congenital captopril? C. Artificial passive D. Natural active A. Dry cough E. Natural passive B. Increase of arterial pressure C. Hyperglycemia 135. A patient has a mental disorder due D. Cardiac rate disorder to the insufficient synthesis of gamma- E. Hypokaliemia aminobutyric acid in the brain. Such pathological changes might be caused by 141. During treatment of chronic cardi- the deficiency of the following vitamin: ac failure with digitoxin a patient developed the drug-specific signs of intoxi- A. Pyridoxine cation. A doctor prescribed Unithiol B. Tocopherol (Dimercaptopropansulfonate sodium). C. Cyanocobalamin Explain its mechanism of action of Unithi- D. Folic acid ol in case of cardiac glycoside intoxication: E. Riboflavin + +

A. Restoration of
-Na -adenosine 136. Soil microflora often contai- triphosphatase activity ns representatives of pathogenic mi- B. Binding of calcium ions croorganisms. Specify the diseases with C. Increase of sodium concentration in causative agents that can remain viable in cardiac hystiocytes the soil for a long time: D. Increase of calciun permeability of cardiac hystiocytes A. Tetanus and gas anaerobic infection E. Binding of glycosides into complex B. Tuberculosis and mycobacterioses compound C. Colibacillosis and cholera D. Leptospirosis and plague 142. An elderly patient suffers from consti- E. Typhoid fever and dysentery pation caused by colon hypotonia. What drug should be prescribed? 137. The method consisting in removal of low-molecular impurities from colloi- dal systems and high-molecular compound solutions by semipermeable membrane di- Krok 1 Pharmacy 2015 15

A. Bisacodyl channel-blocking agent was prescribed for B. Sodium sulfate treatment. Name this agent: C. Castor oil D. Atropine sulfate A. Amlodipine E. Novocainamide (Procainamide) B. Atenolol C. Guanethidine 143. In the course of bronchitis D. Reserpine pharmacotherapy a patient has developed E. Labetalol dyspeptic disorders, photodermatitis and hepatic failure. What drug can cause such 149. A patient suffers from mucosal disorders? dryness and mesopic vision disorder. What vitamin deficiency causes these symptons? A. Doxycycline

B. Paracetamol A. ü

C. Ascorbic acid B. 

D. Acetylcysteine C. 

E. Codeine phosphate D.  E. D 144. The patient with rheumatoid arthritis and concomitant duodenal ulcer has to be 150. Microorganisms that reach blood and prescribed a nonsteroid antiinflammatory other biological systems have negative drug. Which one of the drugs listed below surface charge. What surfactants are used is the drug of choice in the given case? as antibacterial agents to suppress the acti- on of microorganisms? A. Celecoxib B. Acetylsalicylic acid A. Cationic C. Paracetamol B. Anionic D. Metamizole C. Lyophilic E. Diclofenac sodium D. Lyophobic E. Micellar 145. The patient with bronchial asthma had been prescribed salbutamol, which 151. A ready-made drug was inoculated led to disappearance of bronchiospasm on Sabouraud’s agar and incubated under symptoms. It happened due to stimulati- 22oC for 5 days. This nutrient medium was on of: used to determine the following:

A. β2-adrenoreceptors A. Number of mold and yeast fungi B. α1-adrenoreceptors B. Total number of bacteria C. Muscarinic acetylcholine receptors C. Presence of E. coli D. Acetylcholine synthesis D. Presence of S. aureus E. β1-adrenoreceptors E. Presence of Salmonella 146. Choose the most efficient way of 152. The second stage of detoxificati- convallariae glycoside administration for on involves joining certain chemical acute cardiac failure treatment: compounds with functional groups of toxi- nes. Select one such compound: A. Intravenous B. Intramuscular A. Glucuronic acid C. Subcutaneous B. Higher fatty acids D. Internal C. Cholesterol E. Inhalational D. Glucose E. Pyruvate 147. A doctor has prescribed a nonsteroi- dal anti-inflammatory drug to relieve 153. Fatty acids arrive into mitochondria, inflammation and pain syndrome. Name and there their oxidation occurs. Name the this drug: vitamin-like substance that takes part in transportation of fatty acids through mi- A. Diclofenac sodium tochondrial membrane: B. Glibenclamide C. Loratadine A. Carnitine D. Prednisolone B. Choline E. Calcium chloride C. Biotin D. Pantothenic acid 148. A 55-year-old patient had been di- E. Folic acid agnosed with angina pectoris. Calcium Krok 1 Pharmacy 2015 16

154. A 5-year-old child presents with A. Renin abdominal distension, abdominal cramps, B. Cortisol and diarrhea occurring 1-4 hours after C. Vasopressin drinking milk. Described symptoms are D. Noradrenaline caused by the lack of enzymes that break E. Thyroxin up: 160. Micelle of a colloid surfactant will A. Lactose have the following structure in a certain B. Glucose solvent: polar groups are turned towards C. Maltose the solvent, while radicals are facing the D. Saccharose micelle center. What solvent is it? E. Fructose A. Water 155. Fajans titration with fluorescein is B. To l u e n e performed within the following pH range C. Benzene of a medium: D. Tetrachloromethane E. Hydrogen sulfide A. 7-10 B. 1-3 161. What cations of the V analytical group C. 3-5 can be detected by hydrolysis? D. 5-7 E. 10-13 A. Antimony and bismuth B. Manganese 156. Electrode made according to the C. Iron (II) scheme Red, Ox, H+ | Pt belongs to the D. Magnesium following type: E. Iron (III) A. Complex redox electrode 162. A solution of magnesium mixture was B. Ion-selective electrode added into solution with anions of the 1st C. Electrode of the second kind analytical group. White crystalline precipi- D. Electrode of the first kind tate was produced. What anions cause such E. Gas electrode analytical effect? 3− 3− 157. A plant has erect stem with only A. PO4 and AsO4 one leaf growing from each node. What 3− B. AsO3 phyllotaxy is characteristic of this plant? 2− C. S2O3 2− A. Alternate D. SO3 2− B. Opposite E. C2O4 C. Verticillate D. Dichotomous 163. Albumine, blood serum protei- E. Parallel ns, and gastric juice pepsin consist of macromolecules of polypeptide chains 158. Plant pathogens are represented by that are joined with hydrogen bonds into various microorganisms: bacteria, fungi, hydrophilic spheres. These proteins are actinomycetales, viruses. Name the main named: location of plant pathogens in the natural environment: A. Globular B. Fibrillar A. Soil C. Structural B. Water D. Synthetic C. Air E. Artificial D. Plant parts E. Plant vascular system 164. What drug group has the most pronounced vasodilatory action, and has 159. During ultrasound investigation a little effect on cardiac conduction system patient was diagnosed with bilateral and miocardial activity? renal artery stenosis of atherosclerotic genesis. Specify the bioactive substance A. Dihydropyridine derivatives that due to its excessive secretion is the B. Phenylalkylamine derivatives key component of arterial hypertension C. Benzodiazepine derivatives pathogenesis in the given case: D. Sulfonylurea preparations E. β-adrenoceptor agonist 165. A woman is to be prescribed a Krok 1 Pharmacy 2015 17 narcotic analgesic for labor pain relief. gastric ulcer disease was prescribed a What drug is indicated in this case? medicine as a part of his multimodality therapy. The medicine lowers acidity of

A. Promedol (Trimeperidine) + +
gastric juice, inhibits  , -adenosine B. Morphine triphosphatase, decreases the volume of C. Papaveretum (Omnopon) gastric secretion and pepsinogen producti- D. Codeine on. It is a prodrug. Name this medicine: E. Fentanyl A. Omeprazole 166. A woman, who during the 5th-10th B. Famotidine weeks of her pregnancy had been taki- C. Gastrozepin (Pirenzepine) ng sodium valproate for treatment of D. Ranitidine her epilepsy, gave birth to a child with E. Phosphalugel (Aluminium phosphate) pathology of the vertebral column (split spine). What side effect of the drug caused 171. A cultivated plant has green berrylike such malformation? fruit and underground sprout modificati- ons - tubers. The described plant is: A. Teratogenic B. Mutagenic A. Solanum tuberosum C. Embryotoxic B. Соnvalaria majalis D. Fetotoxic C. Polygonatum odoratum E. Sensitizing D. Atropa belladonna E. Solanum lycopersicum 167. A patient with acute bronchitis was prescribed an expectorant that caused 172. Elongated narrow prismatic crystals bronchial spasm after the patient had with sharpened points were detected taken it. What drug of those listed below during microscopic investigation of can cause such side effect? Convallaria majalis mesophile. These crystals are: A. Acetylcysteine B. Salbutamol A. Styloids C. Validol (Menthyl isovalerate) B. Druses D. Platyphyllin C. Crystalline sand E. Prenoxdiazine (Libexin) D. Cystoliths E. Perigonium 168. A patient was visiting a pharmacy, when he suddenly felt unwell. He 173. Students should identify the following developed palpitations, rapid heart rate, to determine the sex of a flower: pain in the chest that after several minutes A. Stamens and pistils spread to the left scapula and left side of B. Flower cup and corolla the head. What condition should be consi- C. Pedicle and receptacle dered first? D. Symmetry A. Ischemic heart disease E. Colour and type of indumentum B. Peptic gastric ulcer disease 174. A doctor prescribed a herbal drug C. Dysphagia with flavonoid complex of Silybum mari- D. Pneumonia anum to a patient suffering from chronic E. Somatoform autonomic dysfunction hepatitis. This hepatic protector stimulates 169. Prolonged application of broad protein synthesis, normalizes phospholipid spectrum antibacterial drugs resulted in metabolism, acts as an antioxidant. Name the patient being hospitalised with di- this drug: agnosis of candidiasis. What side effect A. Silymarin of antibiotic therapy has developed in the B. Essentiale patient? C. Galstena A. Disbacteriosis D. Thiotriasoline B. Endotoxic reaction E. Ursodeoxycholic acid C. Toxic reaction 175. A pharmaceutical manufacture D. Allergic reaction produces a drug, that is an animal antibi- E. Formation of resistant microorganism otic. Point out this drug among those listed strains below: 170. A 37-year-old patient with peptic Krok 1 Pharmacy 2015 18

A. Lysozyme A. Salbutamol B. Gramicidin B. Metoprolol C. Novobiocin C. Atenolol D. Phaseolin D. Anaprilin (Propranolol) E. Chloramphenicol E. Nebivolol 176. A patient has been receiving 181. A 25-year-old-patient with the II Theophylline - inhibitor of cyclic adenosi- degree thermal burns addressed a doctor. ne monophosphate phosphodiesterase - Objectively: there are large blisters on the for a week. What hormone can increase upper limbs; the blisters are filled with its action due to such treatment and cause clear exudate containing mostly water and hyperglycemia? albumines with isolated leukocytes. Name the type of the exudate: A. Glucagon B. Testosterone A. Serous C. Aldosterone B. Catarrhal (mucous) D. Insulin C. Fibrinous E. Estradiol D. Purulent E. Hemorrhagic 177. To detect anions in a solution by fracti- onal method a reaction with iron (III) 182. A seed of a legume contains proteins chloride was performed in acid medium. and fatty oil. Name this legume: The solution coloured red-violet. What anion is the cause of such analytical effect? A. Glycine hispida B. Vaccinium myrtillus A. Salicylate C. Sinapis alba B. Chloride D. Astragalus dasyanthus C. Nitrate E. Datura stramonium D. Bromate E. Phosphate 183. Rhizome of a species belonging to the Asteraceae family is polycephalous, 178. An impression smears of the dead succulent, has lysigenous cavities, person’s brain and salivary glands revealed accumulates inulin. Such underground Negri bodies, when coloured with Mann organ is characterisic of: methyl blue-eosin stain. These results confirm the presence of the following di- A. Inula helenium sease: B. Hyoscyamus niger C. Digitalis grandiflora A. Hydrophobia D. Sorbus aucuparia B. Influenza E. Helianthus annuus C. Parotitis D. Parainfluenza 184. What drug is used in treatment regi- E. Encephalitis men for peptic ulcer disease to eliminate Helicobacter pylori? 179. Preparations of colloid silver - Protargol (silver proteinate) and Collargol A. Clarithromycin (colloid silver) - contain proteine B. Tienam compounds besides their active substance. C. Biseptol What is the function of proteins in these D. Chloridine preparations? E. Sulfalene A. Protection of colloid solution against 185. Sodium hydroxide was added to a coagulation solution. Precipitation occurred. The preci- B. Increased storage time pitate was initially white and became C. Decreased side effects brown later. It indicates the presence of D. Improved preparation technology the following in the solution: E. Increased bactericidal action of silver A. Manganese (II) cations 180. Adrenomimetic agents are differenti- B. Lead (II) cations ated into selective and non-selective. C. Potassium cations D. Calcium cations What drug is an agonist of β2-adrenergic receptors and can be used for treatment of E. Barium cations bronchial asthma? 186. What group of drugs is characterized by development of drug addiction as a side Krok 1 Pharmacy 2015 19 effect? A. Paresis B. Paralysis A. Psychosedatives C. Myasthenia B. Cholinergic antagonists D. Hyperkinesia C. Adrenergic drugs E. Tremor D. Diuretics E. Emetics 193. A 32-year-old patient with cerebellar tumor was delivered to an admission room 187. Some drugs have the form of colloid of a hospital. The patient presents with solutions. What size of dispersed phase ataxia that can be characterized by: particles corresponds with colloidal di- spersion? A. Disrupted coordination of movements B. Involuntary contraction of skeletal A. 10−7 − 10−9 m muscles B. 10−5 − 10−7 m C. Increased muscle tone C. 10−10 − 10−11 m D. Pathological reflexes D. 10−5 − 10−3 m E. Irregular force and direction of E. >10−3 m movements 188. A local general practitioner 194. A doctor prescribed diazepam to recommends taking interferon for a patient with anxiety disorders. What influenza prevention. What is the mechani- pharmacological effect is the reason for sm of action of this drug? such a prescription? A. Blocks virus protein synthesis A. Anxiolytic B. Blocks virus stripping B. Anticonvulsant C. Inhibits virion exit from cells C. Anti-inflammatory D. Prevents adsorption of virus in cell D. Antianginal receptors E. Hypotensive E. Disrupts the process of virus assembly 195. A 40-year-old man presents with rapid 189. What cation can be detected with weight gain after he had suffered a severe Chugaiev’s agent (Dimethylglyoxime)? craniocerebral trauma. At doctor’s exami- nation the patient’s weight was 125 kg, with A. Ni2+ his weight being 175 cm. What mechanism B. Ca2+ of obesity development is the most likely + C.
in this case? D. Mn2+ E. Co2+ A. Hypothalamic B. Alimentary 190. Dry many-seeded monocarp fruit C. Hormonal opens along its ventral suture. It can be D. Hereditary identified as: E. - A. Follicle 196. Specify the parameters that B. Legume characterize the sensitivity of analytical C. Nutlet reaction: D. Drupe E. Capsule A. All the parameters B. Minimal volume of borderline diluted 191. Determination of silver salts by solution ammonium thiocyanate titration is C. Borderline dilution performed in the presence of the following D. Absolute sensitivity indicator: E. Borderline concentration

A. (NH4)Fe(SO4)2 197. Specify the name of the carbohydrate B. FeSO4 given in C. FeCl2 D. (NH4)2SO4 E. NH4SCN 192. After ishemic stroke a 67-year-old patient developed reduced mobility of the left leg. Name this condition: according to the systematic nomenclature: Krok 1 Pharmacy 2015 20

A. 5,6,6-trimethyl-1-hepten B. 2,2,3-trimethyl-6-hepten A. С1 C. 5-tert-Butyl-1-hexene B. С2 D. 2-tert-Butyl-5-hexene C. С3 E. 2,2,3-trimethyl-6-hexene D. С4 198. M. I. Konovalov’s reaction is as E. С5 follows: 200. To chemically distinguish between glycerine and ethylene glycol A. 4 + HNO3(diluted)=CH3NO2 + H2O

B. 4 + H2SO4 = CH3SO2OH + H2O  C. 2 2 5Cl +2Na = C4H10 +2NaCl

it is nececcary to apply:  D. 6 6 + HNO3(concentrated)= C6H5NO2 + H2O

E. 4 + Cl2 = CH3Cl + HCl 199. Hydrogen atom attaches to the A. KHSO4 following carbon-1-pentene atom during B. CuOH electrophilic addition of hydrogen bromi- C. Cu(OH)2 de: D. NaOH E. NaCl

INSTRUCTIONAL BOOK

Testing Board

TEST ITEMS FOR LICENSING EXAMINATION: KROK 1. PHARMACY.

Kyiv. Testing Board. (English language).

Approved to print 26.08./№71. Формат 60х84 1/8 Offset paper. Typeface. Times New Roman Cyr. Offset print. Conditional print pages 24. Accounting publishing pages 20. Issue. 126 copies. List of abbreviations

A/G Albumin/globulin ratio A-ANON Alcoholics anonymous ACT Abdominal computed tomography ALT Alanin aminotranspherase AP Arterial (blood) pressure AST Aspartat aminotranspherase BP Blood (arterial) pressure BR Breathing rate bpm Beats per minute C.I. Color Index CBC Complete blood count CHF Chronic heart failure CT Computer tomography DIC Disseminated intravascular coagulation DCC Doctoral controlling committee DM-2 Non-Insulin dependent diabetes mellitus DTP Anti diphtheria-tetanus vaccine ECG Electrocardiogram ESR Erythrocyte sedimentation rate FC Function class FEGDS Fibro-esphago-gastro-duodenoscopy Gy Gray GIT Gastrointestinal tract Hb Hemoglobin HbA1c Glycosylated hemoglobin Hct, Ht Hematocrit HDL High-density lipoproteins HRIDDM HeartInsulin rate dependent diabetes mellitus IHD Ischemic heart disease IU International unit MSEC Medical and sanitary expert committee NIDDM Non-Insulin dependent diabetes mellitus pCO2 CO2 partial pressure pO2 O2 partial pressure Pm Per minute Ps Pulse rate R Roentgen RBC Red blood count Rh Rhesus RR Respiratory rate S1 (S1) Heart sound 1 S2 (S2) Heart sound 2 TU Tuberculin unit U Unit USI Ultrasound investigation V/f Vision field WBC White blood count X-ray Roentgenogram