Clemson University TigerPrints All Dissertations Dissertations 1-2010 THE DEVELOPMENT OF A MESENCHYMAL STEM CELL BASED BIPHASIC OSTEOCHONDRAL TISSUE ENGINEERED CONSTRUCT Scott aM xson Clemson University,
[email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_dissertations Part of the Biomedical Engineering and Bioengineering Commons Recommended Citation Maxson, Scott, "THE DEVELOPMENT OF A MESENCHYMAL STEM CELL BASED BIPHASIC OSTEOCHONDRAL TISSUE ENGINEERED CONSTRUCT" (2010). All Dissertations. 684. https://tigerprints.clemson.edu/all_dissertations/684 This Dissertation is brought to you for free and open access by the Dissertations at TigerPrints. It has been accepted for inclusion in All Dissertations by an authorized administrator of TigerPrints. For more information, please contact
[email protected]. THE DEVELOPMENT OF A MESENCHYMAL STEM CELL BASED BIPHASIC OSTEOCHONDRAL TISSUE ENGINEERED CONSTRUCT A Dissertation Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Bioengineering by Scott Anthony Maxson May 2010 Accepted by: Dr. Karen J. L. Burg, Committee Chair Dr. Martine LaBerge Dr. Ted Bateman Dr. James Kellam ABSTRACT The ability of human articular cartilage to respond to injury is poor. Once cartilage damage has occurred, an irreversible degenerative process can occur and will often lead to osteoarthritis (OA). An estimated 26.9 million of U.S. adults are affected by OA. Osteochondral grafting is currently used to treat OA and osteochondral defects; however, complications can develop at the donor site and defect area. Osteochondral tissue engineering provides a potential treatment option and alternative to osteochondral grafting. The long term goal of this work is to develop a tissue engineered mesenchymal stem cell (MSC) based osteochondral construct to repair cartilage damage.