ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

Volume 41, Number 1, January 2021

Contents Reviews Chemoradiotherapy in Cancer Treatment: Rationale and Clinical Applications. K.S. RALLIS, T.H.L. YAU, M. SIDERIS (London, UK) ...... 1 The Prognostic Relevance of Computed Tomography-assessed Skeletal Muscle Index and Skeletal Muscle Radiation Attenuation in Patients With Gynecological Cancer. A. GADDUCCI, S. COSIO (Pisa, ) ...... 9 Inguinal GIST: A Systematic Literature Review of Primary and Metastatic Cases. E. VIRGILIO, A. ANNICCHIARICO, L. PAGLIAI, A. MORINI, A. ROMBOLI, F. MONTALI, R. COSTI (Parma; Fidenza; L’Aquila, Italy) ...... 21 Experimental Studies Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells. A. THADI, W.F. MORANO, M. KHALILI, B.D. BABCOCK, M.F. SHAIKH, D.S. FOSTER, Y. PIAZZA, E.M. GLEESON, E. GOLDSTEIN, L. STEELE, P.M. CAMPBELL, B. LIN, M.R. PINCUS, W.B. BOWNE (Philadelphia, PA; Brooklyn, NY, USA) ...... 27 High SLC20A1 Expression Is Associated With Poor Prognoses in Claudin-low and Basal-like Breast Cancers. C. ONAGA, S. TAMORI, H. MOTOMURA, A. OZAKI, C. MATSUDA, I. MATSUOKA, T. FUJITA, Y. NOZAKI, Y. HARA, Y. KAWANO, Y. HARADA, T. SATO, Y. MANO, K. SATO, K. AKIMOTO (Chiba, ) ...... 43 Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes. H. MORIYAMA, K. DAINO, A. ISHIKAWA, T. IMAOKA, M. NISHIMURA, Y. NISHIMURA, M. TAKABATAKE, T. MORIOKA, K. INOUE, M. FUKUSHI, Y. SHIMADA, S. KAKINUMA (Chiba; Tokyo; Aomori, Japan; Washington, DC, USA) ...... 55 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, Greece. P. A. ABRAHAMSSON , Malm , Sweden H. KOBAYASHI, Bethesda, MD, USA ö Tel / Fax: +30-22950-53389. B. B. AGGARWAL, San Diego, CA, USA S. D. KOTTARIDIS, Athens, Greece U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, Highlands, T. AKIMOTO, Kashiwa, Chiba, Japan G. R. F. KRUEGER, K ln, NJ 07732, USA. ö P. Z. ANASTASIADIS, Jacksonville, FL, USA Pat M. KUMAR, Manchester, UK E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA Shant KUMAR, Manchester, UK Managing Editor: [email protected] J. P. ARMAND, Paris , O. D. LAERUM, Bergen, Norway ANTICANCER RESEARCH supports: (a) the establishment and the activities V. I. AVRAMIS, Los Angeles, CA, USA F. J. LEJEUNE, Lausanne, Switzerland of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH (IIAR; D.-T. BAU, Taichung, Taiwan, ROC S. LINDER, Link ping, Sweden Kapandriti, Attiki, Greece); and (b) the organization of the International ö Conferences of Anticancer Research. The IIAR is a member of UICC. For G. BAUER, Freiburg, Germany L. F. 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VOLUME 41 2021 ANTICANCER RESEARCH 41 : (2021)

Editorial Board

P. A. Abrahamsson Department of Urology, Skåne University Hospital, Lund University, Malmö, Sweden B. B. Aggarwal Director, Inflammation Research Center, San Diego, CA, USA T. Akimoto Division of Particle Therapy and Department of Radiation Oncology, National Cancer Center East, Kashiwa, Chiba, Japan P. Z. Anastasiadis Department of Cancer Biology, Mayo Cancer Center, Jacksonville, FL, USA A. Argiris Division of Hematology/Oncology, UT Health Science Center at San Antonio, San Antonio, TX, USA J. P. Armand Institut Gustave Roussy, Paris, France V. I. Avramis Div ision of Hematology/Oncology, Childrens Hospital, Los Angeles, CA, USA D.-T. Bau Terry Fox Cancer Research Lab, China Medical University Hospital, Taichung, Taiwan, ROC G. Bauer Abteilung Virologie, Institut f ür Medizinische Mikrobiologie und Hygiene, Universit ät Freiburg, Germany E. E. Baulieu INSERM U488 and College de France, Le Kremlin- Bic etre, France E. J. Benz, Jr. Dana-Farber Cancer Institute, Boston, MA, USA J.-Y. Blay Centre Léon Bérard, Lyon, France J. Bergh Department of Clinical and Molecular Medicine, Radiumhemmet, Karolinska Inst itute , Stockholm, Sweden F. T. Bosman Institute of Pathology, University of Lausanne, Switzerland M. Bouvet Department of Surgery, University of California San Diego, Moores Cancer Center, La Jolla, CA, USA J. Boyd Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA G. Broich Gruppo Policlinico di Monza, Monza, Italy Ø. S. Bruland Department of Medical Oncology-Radiotherapy, Norwegian Radium Hospital, Oslo, Norway J. M. Buatti Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA M. Carbone Cancer Research Center of Hawaii, Honolulu, HI, USA C. Carlberg Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland A. F. Chambers Department of Oncology, London Regional Cancer Center, London, Ont ario , Canada P. Chandra Abt. für Molekularbiologie, Klinikum Wolfgang Goethe-Universität, Frankfurt am Main, Germany L. Cheng Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA J.-G. Chung Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ROC R. Clarke Georgetown University Medical Center, Washington, DC, USA A.P. Conley Department of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium W. Den Otter VUMC, Department of Urology, Amsterdam, The Netherlands E. P. Diamandis Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto , Ont ario , Canada G. Th. Diamandopoulos Department of Pathology, Harvard Medical School, Boston, MA, USA L. Egevad Department of Pathology, Karolinska University Hospital, Stockholm , Sweden D. W. Felsher Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA J. A. Fernandez-Pol Metalloproteomics, LLC, Chesterfield, MO, USA H. Fu Discovery and Developmental Therapeuticis Program of Winship Cancer Institute, Emory University, Atlanta, GA, USA B. Fuchs Balgrist University Hospital, Zurich, Switzerland D. Fuchs Center for Chemistry and Biomedicine, Innsbruck Medical University, Innsbruck, Austria D. Fukumura Edwin L. Steele Laboratories, Department of Radiation Oncology, Harvard Medical School, Boston, MA, USA G. Gabbiani Department of Pathology, University of Geneva, Switzerland R. Ganapathi Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA

continued ANTICANCER RESEARCH 41 : (2021)

A. Giordano Sbarro Inst itute for Cancer Research, Temple University, Philadelphia, PA, USA M. Gnant Department of Surgery, Medical University of Vienna, Austria R. H. Goldfarb R. H. Goldfarb Sopherion Therapeutics, LLC and Translational Oncology and ImmunoEngineering Consulting, Guilford, CT, USA J.S. Greenberger Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA A. Helland Oslo University Hospital-Radium Hospital, Oslo, Norway L. Helson Sign Path Pharma, Inc., Quakertown, PA, USA R. Henriksson Department of Experimental Oncology, Umeå University, Umeå, Sweden R. M. Hoffman Department of Surgery , University of California, San Diego, CA, USA P. Hohenberger Division of Surgical Oncology and Thoracic Surgery, Medical Faculty, University of Heidelberg, Mannheim, Germany F. Janku Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA S. C. Jhanwar Lab oratory of Solid Tumor Genetics, Department of Medicine, Memorial Sloan-Kettering Cancer C enter , New York, NY, USA J. V. Johannessen Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway R. Jones Sarcoma Unit, Royal Marsden Hospital, London, UK B. Kaina Institute of Toxicology, University of Mainz, Germany P. -L. Kellokumpu-Lehtinen Department of Oncology and Radiotherapy, Tampere University Hospital, Tampere, Finland Helios Medical Center Schleswig, Schleswig, Germany D. G. Kieback R. Klapdor Medical Clinic, University of Hamburg, Germany K.L. Knutson Department of Immunology, Mayo Clinic College of Medicine, Jacksonville, FL, USA H. Kobayashi Laboratory of Molecular Theranostics, NCI/NIH, Bethesda, MD, USA S. D. Kottaridis Department of Virology, Hellenic Anticancer Institute, Athens, Greece G. R. F. Krueger Center of Anatomy II, University of Cologne Medical School, Cologne, Germany Pat M. Kumar Department of Biological Sciences, Manchester Metropolitan University, Manchester, UK Shant Kumar Department Pathology, University of Manchester Medical School, Manchester, UK O. D. Laerum Department of Pathology, The Gade Institute, University of Bergen, Norway F. J. Lejeune Fondation du Centre Pluridisciplinaire d' Oncologie, CHUV, Lausanne, Switzerland S. Linder Department of Medicine and Health, Linköping University, Linköping, Sweden L. F. Liu Department of Pharmacology, UMD of New Jersey, Piscataway, NJ, USA D. M. Lopez Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL, USA E. Lundgren Unit of Applied Cell and Molecular Biology, University of Ume a¨, Sweden Y. Maehara Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan J. Maher Department of Research Oncology, Division of Cancer Studies, King’s College London School of Medicine, Guy’s Hospital Campus, London, UK J. Marescaux IRCAD, University of Strasbourg, France S. S. Martin Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA S. Mitra The Methodist Hospital Research Institute (TMHRI), Houston , TX, USA S. Miyamoto Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan S. Moncada Manchester Cancer Research Centre, University of Manchester, Manchester, UK Hochschule Furtwangen University, Villingen-Schwenningen, Germany M. Mueller F. M. Muggia New York University Cancer Institute, School of Medicine, NY, USA

continued ANTICANCER RESEARCH 41 : (2021)

M. Namiki Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan K. Nilsson Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University Hospital, Sweden S. Pathak Department of Cell Biology, University of Texas, Houston, TX, USA J. L. Persson Section for Experimental Cancer Research, Clinical Research Center, Lund University, Malmö, Sweden G. J. Pilkington Department of Cellular and Molecules Neurooncology, School of Pharmacy and Biomedical Sciences, University of Portsmouth , UK C. D. Platsoucas College of Sciences, Old Dominion University, Norfolk, VA , USA A. Polliack Department of H ae matology, Hadassah University Hospital and Medical School, Jerusalem, Israel D. R ades Department of Radiation Oncology, University of Lübeck, Lübeck, Germany M. Rigaud Lab oratory Biochimie et Génétique Molec ules , Fac ult é de Médecine de Limoges, France U. Ringborg Department of General Oncology, Karolinska Hospital, Stockholm, Sweden M. Roselli Department of Medical Oncology, University of Rome “Tor Vergata”, Italy S.T. Rosen Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA A. Schauer Zentrum Pathologie, Georg-August Universität, Göttingen, Germany M. Schneider Department of Organic Chemistry, Bergische University, Wuppertal, Germany J. Sehouli Department of Gynecology, Center for Oncological Surgery, Charité Comprehensive Cancer Center, Berlin, Germany A. Seth Lab oratory of Molec ular Pathology, Sunnybrook Research Institute and University of Toronto, Ont ario , Canada G. V. Sherbet Cancer Research Unit, University of Newcastle -upon -Tyne, UK A. Slominski Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA Department of Integrated and Holistic Immunology, Faculty of Medicine, Kagawa University, G.-I. Soma Kagawa, Japan

G. S. Stein Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, USA T. Stigbrand Department of Immunology, Ume a¨ University, Ume a¨, Sweden T. M. Theophanides Department of Chemistry, Technical University of Athens, Greece P. M. Ueland Clinical Pharmacolocy Unit, Department of Pharmacology, University of Bergen, Norway H. Van Vlierberghe Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium R.G. Vile Department of Immunology, Mayo Clinic, Rochester, MN, USA M. Weller Department of Neurology, University Hospital Zurich, Zurich, Switzerland J. Westermarck Centre for Biotechnology, University of Turku, Turku, Finland B. Westermark Rudbecklaboratoriet, Department of Genetics and Pathology, University of Uppsala, Sweden Y. Yen Taipei Medical University, Taipei, Taiwan, ROC M. R. I. Young Ralph H. Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC, USA B. Zumoff Div ision of Endocrinology and Metabolism, Beth Israel Medical Center, New York, NY, USA ANTICANCER RESEARCH 41 : (2021)

Acknowledgements

The IIAR appreciates the support of the following Foundations, Institutions, Organizations and Universities for the works published in Anticancer Research, Volume 40, 2020.

AbbVie Pharmaceuticals, Lake Bluff, IL, U.S.A. Ateneo Sapienza University, Rome, Italy Academy of Finland, Helsinki, Finland Augusta University Georgia Cancer Center, Augusta, GA, AceStatistics Support Co, Ltd., Essex, U.K. U.S.A. Advanced Intelligence Project (AIP) - Public/Private R&D Investment Strategic Expansion Program (PRISM), Japan Basic Science Research Program, National Research Science and Technology Agency (JST), Kawaguchi, Foundation of Korea (NRF), Ministry of Education, Japan Science and Technology, , Republic of Korea Advanced Light Microscopy Facility, University of Patras, BBMRI-CZ, Bank of Clinical Specimens Focused on Patras, Greece Cancer, Brno, Czech Republic Advanced Research Foundation, U.S.A. Berlin Air Quality Network, Berlin, Germany Agency for Medical Research, Ministry of Health of the Berlin Institute of Health, Berlin, Germany Czech Republic, Czech Republic Bethel University, Saint Paul, MN, U.S.A. Agioi Anargyroi General Hospital, Athens, Greece Biobank of Kaohsiung Veterans General Hospital, Ajmera Family Chair in Urologic Oncology, Sunnybrook Kaohsiung City, Taiwan, R.O.C. Hospital, Toronto, ON, Canada Biobank of the Center for Integrated Oncology Cologne All Children’s Hospital Foundation, St Petersburg, FL, Bonn, University Hospital Bonn, Bonn, Germany U.S.A. Biohit Oyj, Helsinki, Finland American Cancer Society, Atlanta, GA, U.S.A. Biomedical Research Institute Grant, Kyungpook National American College of Surgeons, Committee on Cancer University Hospital, , Republic of Korea (CoC), Chicago, IL, U.S.A. Biomedical Research Institute, Gyeongsang National American Medical Association, Chicago, IL, U.S.A. University Hospital, Jinju, Republic of Korea Amgen, Thousand Oaks, CA, U.S.A. Bio-oriented Technology Research Advancement Institution An Nan Hospital, China Medical University, Tainan, (BRAIN), National Agriculture and Food Research Taiwan, R.O.C. Organization (NARO), Japan Analytic Healthcare Quality User Information Program of Biophotonics Laboratory, Centro de Biotecnologia the National Research, Development and Innovation (CBiotec), Universidade Federal da Paraíba (UFPB), Fund, Hungarian Government, Hungary Brazil Animal Biotechnology Center, Feature Areas Research Biosignal Research Center, , Kobe, Japan Center Program, Higher Education Sprout Project, Bonati Research Stipend, U.S.A. Ministry of Education in Taiwan, Taiwan, R.O.C. Boston Medical Center Plastic Surgery Department, Applied Medical Research Laboratory, Japan Boston, MA, U.S.A. ARC Foundation, Vancouver, BC, Canada Breast Cancer Hope Foundation, London, U.K. Archie and Betty McCallum, U.S.A. Armauer Hansen Research Institute, Addis Ababa, Ethiopia Canadian Breast Cancer Foundation Endowed Chair in Asan Institute for Life Sciences, Asan Medical Center, Breast Cancer Research, Canada Seoul, Republic of Korea Canadian Cancer Society, Toronto, ON, Canada ASCO Gastrointestinal Cancers Symposium, San Canadian Institutes of Health Research, Ottawa, ON, Francisco, CA, U.S.A. Canada Asia University, Taichung, Taiwan, R.O.C. Canadian Tumour Repository Network (CTRNet), Canada Asociación Costarricense de Oncología Médicos Cancer Association of South Africa (CANSA), South (ACOMED), San José, Costa Rica Africa Association of Healthcare Corporation, Japan Cancer Center Amsterdam, Amsterdam, the Netherlands Associazione Italiana per la Ricerca sul Cancro (AIRC), Cancer Center, Buddhist Tzu Chi General Hospital, Milan, Italy Hualien City, Taiwan, R.O.C. ANTICANCER RESEARCH 41 : (2021)

Cancer Society of Finland, Helsinki, Finland Chosun University, , Republic of Korea Carnegie Large Research Grant, Carnegie Corporation CHU de Poitiers - Hôpital de la Milétrie, Poitiers, France Transformation Programme, University of the CHU Limoges – Dupuytren, Limoges, France Witwatersrand, Johannesburg, South Africa Chuden Hospital, Hiroshima, Japan Center for Animal Experiments, Central Research Chulalongkorn University, Bangkok, Thailand Facilities, Faculty of Medicine, Osaka, CIF Grant, Faculty of Science, Mahidol University, Salaya, Japan Thailand Center for Morphological Analyses, Kindai University City of Hope, National Medical Center, Duarte, CA, Faculty of Medicine, Osaka, Japan U.S.A. Center for NMR Research Facilities, Penn State College of Cleveland Clinic - Global Cardiovascular Innovations Medicine, Hershey, PA, U.S.A. Center, Cleveland, OH, U.S.A. Center for Research Advancement and Collaboration, Japan Clinical Medicine Research Institute, Chosun University Center for Strategic Research Project, University of the Hospital, Gwangju, Republic of Korea Ryukyus, Nishihara, Japan Clinical Medicine Research Laboratory, National Yang- Center for the Integrative and Evolutionary Galliformes Ming University Hospital, Yilan, Taiwan, R.O.C. Genomics (iEGG), Taiwan, R.O.C. Clinical Research Center, Dokkyo Medical University Center of Biotechnology (CBIOT), Universidade Federal School of Medicine, Mibu, Japan do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Clinical Study Support Center, Wakayama Medical Center of Reconstruction Neuroscience –NEURORECON, University Hospital, Wakayama, Japan Czech Republic Clinique de l’Union, Saint-Jean, France Central Health Council, Ministry of Health of Greece, Cohera Medical Inc., Pittsburgh, PA, U.S.A. Athens, Greece Comisión de Operación y Fomentode Actividades Central Norway Regional Health Authority, Norway Académicas (COFAA), Instituto Politécnico Nacional Centre de Radiothérapie et d’Oncologie de Moyenne (IPN), Mexico City, Mexico Garonne, Agen, France Consejo Nacional De Ciencia y Tecnología (CONACyT), Centre Hospitalier de l’Agglomération Montargoise, Mexico City, Mexico Amilly, France Conselho Nacional de Desenvolvimento Cientifico e Centre Hospitalier de Cholet, Cholet, France Tecnologico (CNPq), Brasilia, Brazil Centre Oscar Lambret, Lille, France Control of Innate Immunity Technology Research Centro de Microscopia e Microanálise (CMM), Association, Takamatsu, Japan Universidade Federal do Rio Grande do Sul (UFRGS), Coordenação de Aperfeiçoamento de Pessoal de Nível Porto Alegre, Brazil Superior (CAPES), Brasilia, Brazil Chang Bing Show Chwan Memorial Hospital, Changhua, Core Laboratory, Department of Research, Taipei Tzu Chi Taiwan, R.O.C. Hospital, Buddhist Tzu Chi Medical Foundation, Hualien Changhua Christian Hospital, Changhua, Taiwan, R.O.C. City, Taiwan, R.O.C. Charité - Universitätsmedizin Berlin, Berlin, Germany Council for Science, Technology and Innovation (CSTI), Charles and Mary Latham Foundation Fund, Washington, Cabinet Office, Japan DC, U.S.A. Cross-ministerial Strategic Innovation Promotion Program Charles University in Prague, Prague, Czech Republic (SIP), Japan Charles University Research Fund (PROGRES), Charles CytoGen Inc., Seoul, Republic of Korea University in Prague, Prague, Czech Republic Czech Science Foundation, Czech Republic Chia-Yi Christian Hospital, Chia-Yi, Taiwan, R.O.C. Children's Oncology Group, Seattle, WA, U.S.A. Daisan Hospital, Jikei University, Tokyo, Japan Chi-Mei Medical Center, Tainan, Taiwan, R.O.C. Daiwa Securities Health Foundation, Tokyo, Japan China Medical University Hospital, Taichung, Taiwan, Danish Cancer Association, Copenhagen, Denmark R.O.C. Danish Gynaecological Cancer Database, Copenhagen, China Medical University, Taichung, Taiwan, R.O.C. Denmark China Scholarship Council (CSC), P.R. China Dean of Research and Graduate Studies, Federal University Cholangiocarcinoma Research Institute (CARI), Thailand of Pará, Belem, Brazil ANTICANCER RESEARCH 41 : (2021)

Deanship of Scientific Research (DSR), King Abdulaziz Department of Next Generation Cell and Immune Therapy, University, Jeddah, Saudi Arabia Juntendo University School of Medicine, Tokyo, Japan DEKART Proteomics Laboratory, Kocaeli University Department of Oncology, University Hospital of Lausanne- Medical School, Kocaeli, CHUV, Lausanne, Switzerland Department of Biostatistics, Catholic Research Department of Otorhinolaryngology Head and Neck Coordinating Center, The Catholic University of Korea, Surgery, University Hospital Mannheim, University of , Republic of Korea Heidelberg, Mannheim, Germany Department of Biostatistics, Yokohama City University Department of Pathology and Laboratory Medicine, School of Medicine, Yokohama, Japan Nagoya University of Hospital, Nagoya, Japan Department of Breast and Endocrine Surgery, Osaka City Department of Pathology, Kanagawa Cancer Center, University Graduate School of Medicine, Osaka, Japan Yokohama, Japan Department of Chemistry, Howard University, Washington, Department of Pathology, Kangbuk Samsung Hospital, DC, U.S.A. Seoul, Republic of Korea Department of Clinical and Translational Physiology, Department of Pathology, Medical School, University of Kyoto Pharmaceutical University, Kyoto, Japan Athens, Athens, Greece Department of Clinical Oncology, Kyoto Pharmaceutical Department of Pathology, Nagasaki University Hospital, University, Kyoto, Japan Nagasaki, Japan Department of Clinical Statistics, Graduate School of Department of Pathology, Hospital, Medicine, Yokohama City University, Yokohama, Japan Osaka, Japan Department of Education Title III Program, Clark Atlanta Department of Pathology, Saitama Medical University University, Atlanta, GA, U.S.A. International Medical Center, Saitama, Japan Department of Environmental Medicine, Kurume Department of Pathology, School of Medicine, Aristotle University School of Medicine, Kurume, Japan University of Thessaloniki, Thessaloniki, Greece Department of Experimental, Diagnostic and Specialty Department of Pediatrics, University of California San Medicine (DIMES), S. Orsola-Malpighi University Diego School of Medicine, San Diego, CA, U.S.A. Hospital, Bologna, Italy Department of Pharmacology and Therapeutics, Faculty of Department of Gastroenterological Surgery, Osaka Pharmacy, Kuwait University, Kuwait City, Kuwait University Graduate School of Medicine, Osaka, Japan Department of Physiology, School of Medicine, Department of Gastroenterology and Hepatology, Nagoya Autonomous National University of Mexico (UNAM), University Graduate School of Medicine, Nagoya, Japan Mexico City, Mexico Department of General Thoracic Surgery and Breast and Department of Preventive Medicine, Tokai University Endocrinological Surgery, Okayama, Japan School of Medicine, Hiratsuka, Japan Department of Histology and Embryology, Lithuanian Department of Radiation Oncology, Gunma University University of Health Sciences, Kaunas, Lithuania Graduate School of Medicine, Maebashi, Japan Department of Integrated Diagnostic Pathology, Nippon Department of Radiation Oncology, Osaka International Medical School, Tokyo, Japan Cancer Institute, Osaka, Japan Department of Internal Medicine – Oncology, General Department of Radiation Oncology, Stanford University Hospital of Thessaloniki Papageorgiou, Thessaloniki, School of Medicine, California, CA, U.S.A. Greece Department of Radiotherapy, Yamaguchi University Department of International Medical Communications, Graduate School of Medicine, Ube, Japan Tokyo Medical University, Tokyo, Japan Department of Surgery, International University of Health Department of Medical Research, China Medical and Welfare Hospital, Ōtawara, Japan University Hospital, Taichung, Taiwan, R.O.C. Department of Surgery, University of Pécs Medical School, Department of Medicine Clinic III, Hematology, Oncology Pécs, Hungary and Palliative Medicine, Rostock University Medical Department of Urology, Arad Hospital, Tehran, Iran Center, Rostock, Germany Department of Urology, Kyoto Prefectural University of Department of Neuroscience, Imaging and Clinical Medicine, Kyoto, Japan Sciences, “G. D’Annunzio” University of Chieti, Chieti, Departments of Medicine and Radiation Oncology, Rutgers Italy New Jersey Medical School, Newark, NJ, U.S.A. ANTICANCER RESEARCH 41 : (2021)

Departments of Pathology and Thoracic Surgery, Kanazawa Federal Ministry of Transport, Innovation and Technology Medical University, Uchinada, Japan (BMVIT), Vienna, Austria Departments of Surgery and Pharmacology and Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Drexel University College of Medicine, Philadelphia, PA, Brazil U.S.A. Financiadora de Estudos e Projetos (FINEP), Brazil Development of Characteristic Education Grant, Japan First Faculty of Medicine, Charles University in Prague, Private School Promotion Foundation, Japan Prague, Czech Republic Ditmanson Medical Foundation, Chiayi Christian Hospital, Fondation du Cancer du Sein du Québec, Montreal, Chiayi, Taiwan, R.O.C. Canada Division of Oncology, Department of Medicine, University Fondazione Cassa di Risparmio di Perugia, Perugia, Italy General Hospital, Patras, Greece Fondazione Roma, Rome, Italy Dutch Cancer Society, Amsterdam, the Netherlands Fonds de Recherche du Québec - Santé (FRQS), Montreal, Canada E-Da Cancer Hospital, Kaohsiung, Taiwan, R.O.C. Foundation for the Promotion of Cancer Research, Japan EDGC, Inc., , Republic of Korea Foundation of Osaka Cancer Research, Osaka, Japan Edmond Odette Foundation, Toronto, ON, Canada Friedrich-Alexander-University Erlangen-Nuremberg Engdahl Family Foundation, Anoka, MN, U.S.A. (FAU), Erlangen, Germany Engineering Division, Hospital de Clínicas de Porto Alegre Fukuoka Foundation for Sound Health Cancer Research (HCPA), Porto Alegre, RS, Brazil Fund, Japan Epidemiological Strategy and Medical Economics (ESME) Fukuoka Wajiro Hospital, Fukuoka, Japan Scientific Committee, Fulbright Program, U.S.A. Erasmus University Rotterdam, Rotterdam, the Netherlands Fundação de Amparo à Pesquisa do Estado do Piauí Estímulo alDesempeño de los Investigadores (EDI) of IPN, (FAPEPI), Brazil Paris, France Fundação de Amparo à Pesquisa do Estado do Rio de Ethicon Endosurgery, Cincinnati, OH, U.S.A. Janeiro (FAPERJ), Brazil Ethiopian Airlines Health Office, Addis Ababa, Ethiopia Fundação de Amparo à Pesquisa do Estadodo Rio Grande European MRI and Rectal Cancer Surgery (EuMaRCS) do Sul (FAPERGS), Brazil Study Group Fundação de Apoio à Pesquisa do Estado da Paraíba European Regional Development Fund (ERDF), Brussels, (FAPESQ-PB),Brazil Belgium Fundação para a Ciência e a Tecnologia (FCT), Ministério European Research Council da Ciência e Ensino Superior, Portugal European Social Fund, Brussels, Belgium Fundo Europeu de Desenvolvimento Regional (FEDER), European Union’s Seventh Framework Program Lisbon, Portugal EVO-funding, Kuopio University Hospital, Kuopio, Finland Gachon University, Incheon, Republic of Korea Excellence Program, State of Mecklenburg-Vorpommern, General Hospital of Heraklion Pananio-Venizelio, Germany Heraklion, Greece Experimental, Educational and Research Center ELPEN, General University Hospital in Prague, Prague, Czech Greece Republic Georgia Research Alliance (GRA) Venture Lab Grant, Faculty of Dentistry, Thammasat University, Bangkok, U.S.A. Thailand German Cancer Research Center (DKFZ), Heidelberg, Faculty of Medicine, University of Porto, Porto, Portugal Germany Faculty of Pharmaceutical Sciences, Chulalongkorn German Federal Ministry of Education and Research University, Bangkok, Thailand (BMBF), Germany Far Eastern Memorial Hospital, New Taipei, Taiwan, Gil Medical Center, Gachon University, Incheon, Republic R.O.C. of Korea Federal Ministry of Science, Research and Economy GINECO Study Office (BMWFW), Vienna, Austria GlaxoSmithKline plc, London, U.K. ANTICANCER RESEARCH 41 : (2021)

Global Robotics Institute, Florida Hospital, Orlando, FL, Hyogo Prefectural Amagasaki General Medical Center, U.S.A. Hyogo, Japan Graduate Research Group of the Hospital de Clínicas de Porto Alegre (GPPG), Porto Alegre, Brazil Icahn School of Medicine at Mount Sinai, New York, NY, Graduate School of Pharmaceutical Sciences, Osaka U.S.A. University, Osaka, Japan Ichiro Kanehara Foundation, Promotion of Medical Science Graduate School, Chulalongkorn University, Bangkok, and Medical Care, Japan Thailand IC-MedTech Co., San Diego, CA, U.S.A. Graduate School, Khon Kaen University, Khon Kaen, Iizuka Hospital, Fukuoka, Japan Thailand Inje University Paik Hospital, Busan, Republic of Grand Forks Human Nutrition Research Center, Korea Washington, DC, U.S.A. Innovative Medicines Initiative, Brussels, Belgium Grant-in-Aid for Scientific Research, Ministry of Health, Institut Jean Godinot, Reims, France Labor and Welfare, Tokyo, Japan Institute for Experimental Surgery, University of Rostock, Grants-in-Aid for Scientific Research (KAKENHI), Japan Rostock, Germany Society for the Promotion of Science, Tokyo, Japan Institute of Biomathematics, University Hospital Greek National Funds, Athens, Greece Mannheim, University of Heidelberg, Mannheim, Grigore T. Popa University of Medicine and Pharmacy, Germany Iasi, Romania Institute of Cytology and Genetics, Novosibirsk, Russia Grünenthal Foundation, Portugal Institute of Medical Biochemistry and Laboratory GSTU Foundation, Palermo, Italy Diagnostics, First Faculty of Medicine, Charles Gunma University Heavy-Ion Medical Center, Gunma, University, Prague, Czech Republic Japan Institute of Medical Biometry and Statistics, University of Gunma University Hospital, Gunma, Japan Freiburg, Freiburg im Breisgau, Germany Gyeongsang National University Hospital Biomedical Institute of Medical Science, The University of Tokyo, Research Institute, Jinju, Republic of Korea Tokyo, Japan Institute of Molecular and Cellular Biology, Novosibirsk, Hadassah Braun School of Public Health, Hebrew Russia University, Jerusalem, Israel Instituto de Pesquisa em Fármacos e Medicamentos Hallym University Research Fund, Chuncheon, Republic of (IPeFarM), Universidade Federal da Paraíba (UFPB), Brazil Korea intégrale Co., Ltd., Tokushima, Japan Harasanshin Hospital, Fukuoka, Japan International Research Network, Thailand Research Fund Heikki, Aino and Aarne Korhonen Foundation, Finland (TRF), Thailand Hellenic Society of Medical Oncology (HeSMO), Athens, Interreg Deutschland-Danmark, Kiel, Germany Greece Intramural Funding of the School of Medicine and Health Helsinki University Central Hospital Research Foundation, Sciences, University of Oldenburg, Oldenburg, Germany Helsinki, Finland Intramural Research Program, National Cancer Institute, Heuermann HF Technik, Aachen, Germany National Institutes of Health, Department of Health and Higashiosaka City Medical Center, Osaka, Japan Human Services, Bethesda, MD, U.S.A. High Throughput Biomedicine Unit (HTB), Institute for Inui Immunotherapy Clinic, Osaka, Japan Molecular Medicine Finland (FIMM), Finland Iran National Scientific Foundation (INSF), Iran Hiroshima Red Cross Hospital and Atomic-bomb Survivors I-Shou University, Kaohsiung, Taiwan, R.O.C. Hospital, Hiroshima, Japan Italian Association of Radiation Oncology (AIRO) Group Hôpital Privé DrômeArdèche - Clinique Pasteur, for Gastrointestinal Cancer, Italy Guilherand-Granges, France Italian Ministry of Health, Italy Hôpital Privé Sainte-Marie, Chalon-sur-Saône, France Hospital Bichat, Paris, France Jane and Aatos Erkko Foundation, Finland Howard University, Washington, D.C., U.S.A. Japan Agency for Medical Research and Development Human Genome Center, Japan (AMED), Tokyo, Japan ANTICANCER RESEARCH 41 : (2021)

Japan Science and Technology Agency (JST), Kawaguchi, Kuopio University Hospital Research Foundation, Kuopio, Japan Finland Japanese Respiratory Foundation, Tokyo, Japan Kuwait University, Seoul, Republic of Korea Japanese Society for Radiation Oncology, Japan Kyoto Pharmaceutical University, Kyoto, Japan JCHO Kyushu Hospital, Kitakyushu, Japan Kyung Hee University, Seoul, Republic of Korea Jikei University School of Medicine, Tokyo, Japan Kyungpook National University Hospital, Daegu, Republic of Korea K2M Group, Leesburg, VA, U.S.A. Kyushu Breast Cancer Study Group, Fukuoka, Japan Kanagawa Cancer Center Hospital-Research Institute, Kyushu Central Hospital, Fukuoka, Japan Kanagawa, Japan Kanzawa Medical Research Foundation, Yoshino, Japan Laboratório Central de Microscopia Eletrônica (LCME), Kaohsiung Medical University Hospital, Kaohsiung, Universidade Federal de Santa Catarina (UFSC), Taiwan, R.O.C. Florianópolis, SC, Brazil Karolinska Institute, Stockholm, Sweden Laboratório de Tecnologia Mineral e Ambiental (LTM), Kawaguchi Municipal Medical Center, Kawaguchi, Japan Universidade Federal do Rio Grande do Sul (UFRGS), Kawasaki Medical School General Medical Center, Porto Alegre, Brazil Okayama, Japan Laboratório Multiusuários de Estudos em Biologia Kawasaki Medical School, Kurashiki, Japan (LAMEB), Centro de Ciências Biológicas (CCB), K-computer, RIKEN Advanced Institute for Computational Universidade Federal de Santa Catarina (UFSC), Science, HPCI System Research Project, Japan Florianópolis, SC, Brazil Khon Kaen University Research Fund, Khon Kaen, Laboratory of Molecular Oncology, Hellenic Foundation Thailand for Cancer Research, Hellenic Cooperative Oncology Khon Kaen University, Khon Kaen, Thailand Group, Aristotle University of Thessaloniki, Greece KI.EI.OTO.YO Support Foundation, MSD Life Science Laboratory of Natural Products (LPN), Universidade Foundation, Astellas Research Support, Astellas Pharma Federal do Piauí (UFPI), Teresina, Brazil Inc., Tokyo, Japan Leading Graduate Schools, Cultivating Global Leaders in Kissei Pharmaceutical Co. Ltd., Matsumoto, Japan Heavy-Ion Therapeutics and Engineering, Japan Kitakyushu Municipal Medical Center, Kitakyushu, Japan LEO Foundation, Copenhagen, Denmark KKU Publication Clinic, Thailand Lindhés Advokatbyrå AB, Stockholm, Sweden Knut & Alice Wallenberg Foundation, Uppsala, Sweden Lion’s 5M Hearing Center Grant, Minneapolis, MN, Kobe University, Kobe, Japan U.S.A. Kocaeli University, Izmit, Turkey Lithuanian Research Council, Lithuania Korea Chemical Ban, Korea Research Institute of Chemical Technology, Republic of Korea Macrophi Inc., Kagawa, Japan Korea Health Technology R&D Project, Korea Health Mahidol University, Salaya, Thailand Industry Development Institute (KHIDI), Ministry of Marmara University Scientific Research Projects, , Health & Welfare, Seoul, Republic of Korea Turkey Korea Institute of Oriental Medicine (KIOM), Republic of Mayo Clinic Center for Individualized Medicine, Korea Rochester, MN, U.S.A. Korea Institute of Radiological and Medical Sciences Medical Centre Rotterdam, Rotterdam, the Netherlands (KIRAMS), Ministry of Science, ICT and Future Medical Faculty, University of Pecs, Pecs, Hungary Planning (MSIP), Gwacheon, Republic of Korea Medical Research Center (MRC) Program, National Korea National University of Transportation, Chungju, Research Foundation of Korea (NRF), Republic of Korea Republic of Korea Medical Research Core Facilities Center, Office of Korea Research Institute of Chemical Technology, Daejeon, Research & Development, China Medical University, Republic of Korea Taichung, Taiwan, R.O.C. Korea University Grant, Seoul, Republic of Korea Medical Research Council (MRC), London, U.K. Korean Research Institute of Bioscience and Biotechnology Medical Science Research Institute Grant, Kyunghee Research Initiative Program (KRIBB), Republic of Korea University Hospital, Gangdong, Republic of Korea ANTICANCER RESEARCH 41 : (2021)

Medical University of Bialystok, Bialystok, Poland National Hospital Organization Osaka National Hospital, Medical University of Gdansk, Gdansk, Poland Osaka, Japan Medical University of Lublin, Lublin, Poland National Institute for General Medical Science (NIGMS), Medical University Science Park in Košice, Slovakia National Institutes of Health (NIH), Department of Medicinal Plants Research Center (NPPM), Federal Health and Human Services, Bethesda, MD, U.S.A. University of Piauí, Teresina, Brazil National Institute of Minority Health and Health Medtronic plc, Fridley, MN, U.S.A. Disparities (NIMHD), NIH, Bethesda, MD, U.S.A. Merck Serono S.A., Darmstadt, Germany National Institute of Nursing Research, National Institutes Mesothelioma Applied Research Foundation, Washington, of Health (NIH), Bethesda, MD, U.S.A. D.C., U.S.A. National Institutes of Health (NIH), Department of Health Middle Tennessee State University, Murfreesboro, TN, and Human Services, Bethesda, MD, U.S.A. U.S.A. National Natural Science Foundation of China Minerva Foundation, Finland National Research Foundation (NRF)-Thuthuka Grant, Ministério da Ciência e Tecnologia (MCT), Brazil Pretoria, South Africa Ministry of Education and Science of the Russian National Science Centre Grant Opus, Poland Federation Natural Science Foundation of Guangxi, P.R. China Ministry of Education, Culture, Sports, Science and Nelson Mandela University, Port Elizabeth, South Africa. Technology (MEXT), Tokyo, Japan Newton Advanced Fellowship, Thailand Research Fund, Ministry of Education, Youth and Sports of the Czech Thailand Republic Nihon University, Chiyoda, Japan Ministry of Health and Welfare, Taiwan, R.O.C. Nikkyoko Research Award, Japan Ministry of Health of the Czech Republic Norwegian University of Science and Technology (NTNU), Ministry of Innovation and Technology, Hungary Trondheim, Norway Ministry of Science and Technology, Taiwan, R.O.C. Novartis International AG, Basel, Switzerland Ministry of Science, ICT & Future Planning (MSIP), Novartis Oncology (Hellas), Athens, Greece Republic of Korea Novartis Pharma GmbH, Nuremberg, Germany Minor Equipment Grant WHC Dividend, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Ogata Foundation, Japan South Africa Ohio State University College of Pharmacy, Columbus, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan OH, U.S.A. OHSU Knight BioLibrary, Portland, OR, U.S.A. Nagasaki University Hospital, Nagasaki, Japan OHSU Knight Diagnostic Laboratories, Portland, OR, Nanjing Medical Science and Technology Development U.S.A. Foundation, P.R. China Oita Cancer Research Foundation, Oita, Japan National Cancer Institute (NCI), National Institutes of Oita Red Cross Hospital, Oita, Japan Health, Department of Health and Human Services, Graduate School of Medicine, Bethesda, MD, U.S.A. Dentistry and Pharmaceutical Sciences, Okayama, Japan National Cancer Research Institute, Tokyo, Japan Onassis Foundation, Athens, Greece National Center for Advancing Translational Sciences Oncodesign, France (NCATS), National Institutes of Health, Department of Oncology Department, University of Oxford, Oxford, U.K. Health and Human Services, Bethesda, MD, U.S.A. Oncolyze Inc., New York, NY, U.S.A. National Center for Research and Development, Warsaw, Ono pharmaceutical Co., Ltd, Osaka, Japan Poland Opal Oncology Ltd., Cambridge, U.K. National Centre for Research and Development Operational Programme “Innovative Economy”, European Strategmed, Poland Regional Development Fund (ERDF), European Union National Clinician Scholars Program, Duke University, Operational Programme Competitiveness, Entrepreneurship Durham, NC, U.S.A. and Innovation (EPAnEK), European Union National Health and Medical Research Council of Australia Operational Programme Research, Development and National Health Research Institute, Taiwan, R.O.C. Education (OP RDE), European Union ANTICANCER RESEARCH 41 : (2021)

Organic Synthesis Shared Resource, Penn State Cancer Research Fund of the Department of Medical Research, China Institute, Hershey, PA, U.S.A. Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate School of Medicine, Research Fund of Tung’s Taichung Metro Harbor Hospital, Osaka, Japan Taichung, Taiwan, R.O.C. Osaka City University Hospital, Osaka, Japan Research in Design for Discovery Within Learning Osaka General Medical Center, Osaka, Japan Environments (RIDDLE Lab), New York, NY, U.S.A. Oulu University Hospital MRC Grant, Oulu, Finland Research Incentive Fund, Fundo de Incentivo à Pesquisa e Eventos (FIPE), Hospital de Clínicas de Porto Alegre Päivikki ja Sakari Sohlberg Foundation, Helsinki, Finland (HCPA), Porto Alegre, Brazil Palacky University Olomouc, Olomouc, Czech Republic Research Institute for Convergence of Biomedical Science Penn State Hershey Milton S. Hershey Medical Center, and Technology Grant, Pusan National University Hershey, PA, U.S.A. Yangsan Hospital, Yangsan, Republic of Korea Pharma Crea Kobe Co.Ltd., Kobe, Japan Research Instrument Center, Khon Kaen University, Khon PharmaMar, Colmenar Viejo, Spain Kaen, Thailand Picower Institute, Massachusetts Institute of Technology, Research Project with Heavy Ions, National Institute of Cambridge, MA, U.S.A. Radiological Sciences, Technology of Japan, Chiba, Japan Plastic Surgery Foundation, Arlington Heights, IL, U.S.A. Research Resettlement Fund, Seoul National University, Polish Adult Leukemia Group (PALG), Poland Seoul, Republic of Korea Polish Ministry of Science and Higher Education Research Support Center, Kyushu University Graduate Polish National Science Center School of Medical Sciences, Fukuoka, Japan Polka Dot Mama Melanoma Foundation, Cary, NC, U.S.A. Réseau de recherche sur le cancer, Canada Priority Issue on Post-K Computer, Tokyo, Japan Roche S.A.S., Paris, France Programa de Apoio a Núcleos Emergentes (PRONEM), Roswell Country Club Prostate Cancer Research Award, Brazil Winship Cancer Institute, Emory University, Atlanta, Programa Institucional de Formación de Investigadores del GA, U.S.A. IPN (PIFI), Mexico Roswell Park Cancer Institute, Buffalo, NY, U.S.A. Programa Operacional Capital Humano (POCH), Portugal Royal College of Surgeons of England, London, U.K. Project for Cancer Research and Therapeutic Evolution (P- Royal Society, Bangkok, Thailand CREATE), Japan Agency for Medical Research and Russian Ministry of Science and High Education Development (AMED), Tokyo, Japan Ryukyu Society for the Promotion of Oto-Rhino- Pró-Saúde Associação Beneficente de AssistênciaSocial e Laryngology, Japan Hospitalar, Brazil Public Trust Surgery Research Fund, Japan S&P GmbH, Augsburg, Germany Sagara Hospital, Alappuzha, India QST Hospital, Chiba, Japan Saudi Arabian Ministry of Education Quantum and Radiological Science and Technology (QST), Science Achievement Scholarship, Thailand National Institute of Radiological Sciences (NIRS), Science of Health Care Delivery, Robert D. and Patricia E. Chiba, Japan Kern Center, Rochester, MN, U.S.A. Scientific Cancer Cell Biology Group, Wroclaw Medical Radiumhospitalets Legater, Oslo, Norway University, Wroclaw, Poland Ratchadaphiseksomphot Fund, Chulalongkorn University, Screening Laboratory of Biological Activity Test and Bangkok, Thailand Collection of Biological Material, Faculty of Pharmacy, RayVio Corp., Hayward, CA, U.S.A. Division of Laboratory Diagnostics, Wroclaw Medical Research Administration, Kuwait University Research University, Wroclaw, Poland Grant, Kuwait City, Kuwait Senior Research Scholar Grant, Thailand Research Fund, Research Center for Molecular Medicine, Analysis Center Bangkok, Thailand of Life Science, Faculty of Medicine, Hiroshima Seoul National University Hospital (SNUH) Research University, Hiroshima, Japan Fund, Seoul, Republic of Korea Research Fund of Istanbul University, Istanbul, Turkey SGH Foundation, Japan ANTICANCER RESEARCH 41 : (2021)

Shinshu Medical Foundation, Matsumoto, Japan Taiwan Ministry of Science and Technology Shizuoka Cancer Center Hospital, Shizuoka, Japan Takeda Foundation for Medical Science, Japan Shizuoka Prefectural Government, Japan Takeda Science Foundation, Japan Showa University, Shinagawa, Japan Taoyuan General Hospital, Ministry of Health and Welfare, Sigma Zeta National Science & Mathematics Honor Taipei, Taiwan, R.O.C. Society Student Research Award, Lebanon, IL, U.S.A. Taussig Cancer Center Bridge Grant Program, Cleveland, Sigrid Jusélius Foundation, Finland OH, U.S.A. Sistema Nacional de Investigadores (SNI), Mexico City, Tella Inc., Tokyo, Japan Mexico Thailand Research Fund, Bangkok, Thailand Slovak Grant Agency, Bratislava, Slovakia Thailand Science Research and Innovation, Thailand Slovak Research and Development Agency, Bratislava, Research Fund, Bangkok, Thailand Slovakia Thammasat University, Bangkok, Thailand Smoking Research Foundation, Japan The Cancer Foundation of Northern Savo, Finland Social Hearth Corporation Foundation Pond Friends The City University of New York, New York, NY, U.S.A. Association, Fukuoka Wajiro Hospital, Fukuoka, Japan The Elsa U. Pardee Foundation, Midland, MI, U.S.A. Soonchunhyang University Research Fund, Asan, Republic The Finnish Cultural Foundation, Finland of Korea The Second Century Fund (C2F), Thailand St. Luke’s International University, Tokyo, Japan Thomas Jefferson University, Philadelphia, PA, U.S.A. Statutory Funds, Department of Molecular and Cellular Tissue Bank, China Medical University, Taichung, Taiwan, Biology, National Science Centre, Warsaw, Poland R.O.C. Stellenbosch University, Stellenbosch, South Africa Tokai University School of Medicine Research Aid, Tokyo, Stockholm Cancer Society, Stockholm, Sweden Japan Stockholm City Council, Stockholm, Sweden Tokushima University Graduate School, Tokushima, Japan Strategic Promotion for Practical Application of Innovative Tokyo Association for Clinical Surgery, Tokyo, Japan Medical Technology (TR-SPRINT), Japan Tokyo Medical University, Tokyo, Japan Strategic Research Council of Denmark, Denmark Tokyo Shinagawa Hospital, Tokyo, Japan Stroke Grant Tokyo University of Science, Tokyo, Japan Styrian Business Promotion Agency (SFG), Graz, Austria TPP Global Development, Edinburgh, U.K. Sunplanet Co., Ltd., Tokyo, Japan Translational Research Laboratory, Taiho Pharmaceutical Supercomputer System, Human Genome Center, Institute Co., Ltd., Tokyo, Japan of Medical Science, University of Tokyo, Tokyo, Japan Translational Research Program, Japan Support Centre for Medical Research and Education, Tokai Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan University, Tokyo, Japan Swedish Cancer and Allergy Foundation, Sweden UC Davis Paul Calabresi Career Development Award for Swedish Cancer Foundation, Sweden Clinical Oncology, National Cancer Institute/National Swedish Cancer Society, Sweden Institutes of Health, Bethesda, MD, U.S.A. Swedish Childhood Cancer Fund, Sweden Unidad de Investigación Médica en Enfermedades Swedish Heart and Lung Foundation, Sweden Oncológicas (UIMEO), Mexico City, Mexico Swedish Research Council, Sweden Unidad de Servicio de Apoyo a la Investigación y a la Szeged Foundation for Cancer Research, Szeged, Hungary Industria (USAII), Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico Taichung Armed Forces General Hospital, Taichung, City, Mexico Taiwan, R.O.C. Unidade de Investigação em Epidemiologia (EPIUnit), Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. Instituto de Saúde Pública da Universidade do Porto Taiho Pharmaceutical Co., Ltd., Tokyo, Japan (ISPUP), Porto, Portugal Taipei Municipal Wanfang Hospital, Taipei, Taiwan, R.O.C. United States Patent and Trademark Office (USPTO), Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Alexandria, VA, U.S.A. Foundation, Taipei, Taiwan, R.O.C. University Hospital Pilsen, Pilsen, Czech Republic Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. University Hospital Sharjah, Sharjah, United Arab Emirates University of Adelaide, Adelaide, Australia Wake Forest University, Winston-Salem, NC, U.S.A. University of Alabama at Birmingham (UAB) Flow Walailak University, Nakhon Si Thammarat, Cytometry Core, Birmingham, AL, U.S.A. Thailand University of Pecs, Pecs, Hungary Western University of Health Sciences, Pomona, CA, University of South Florida (USF) Research Computing, U.S.A. Tampa, FL, U.S.A. Wilhelm-Sander Foundation, Munich, Germany University of the Witwatersrand, Johannesburg, South Wroclaw Centre of Biotechnology, Wroclaw, Poland Africa Wroclaw Medical University, Wroclaw, Poland University of Tokushima Graduate School, Tokushima, Japan University of Tokyo, Tokyo, Japan Yamaga City Medical Center, Yamaga, Japan University of Tsukuba, Tsukuba, Japan Yamaguchi Rosai Hospital, Sanyo-Onoda, Japan UNT Health Science Center (UNTHSC), Fort Worth, TX, Yao Municipal Hospital, Osaka, Japan U.S.A. Yen Tjing Ling Medical Foundation, Taipei, Taiwan, URC Grant, University Research Committee, University of R.O.C. the Witwatersrand, Johannesburg, South Africa Yokohama Surgical Research Group, Yokohama, Japan Veterans Administration Merit Awards, Washington, DC, Yoshiki Dermatology Clinic Ginza, Tokyo, Japan U.S.A. Vienna Business Agency, Vienna, Austria Zeincro Hellas, Athens, Greece Review s