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Front Matter (PDF) ISSN: 0258-851X International Journal of Experimental and Clinical Pathophysiology and Drug Research Volume 35 , Number 1, January-February 2021 Contents Reviews Suturing Skills for Medical Students: A Systematic Review. T. EMMANUEL, M. NICOLAIDES, I. THEODOULOU, W. YOONG, N. LYMPEROPOULOS, M. SIDERIS (London, UK) ............................ 1 Therapeutic Application of Mesenchymal Stem Cells for Cochlear Regeneration. N. MAHARAJAN, G.W. CHO, C.H. JANG (Gwangju, Republic of Korea) ........................................................................ 13 Sensitivity, Specificity and the Diagnostic Accuracy of PET/CT for Axillary Staging in Patients With Stage I-III Cancer: A Systematic Review of The Literature. J. KASEM, U. WAZIR, K. MOKBEL (London, UK; Peshawar, Pakistan) ........................................................................................................ 23 Circulating Tumor Cells, Circulating Tumor DNA and Other Blood-based Prognostic Scores in Pancreatic Ductal Adenocarcinoma – Mini-Review. M. LIBERKO, K. KOLOSTOVA, A. SZABO, R. GURLICH, M. OLIVERIUS, R. SOUMAROVA (Prague, Czech Republic) ............................................. 31 Aortitis – An Interdisciplinary Challenge. T. SHCHETYSNKA-MARINOVA, K. AMENDT, M. SADICK, M. KEESE, M. SIGL (Mannheim, Germany) .......................................................................................... 41 The Role of Nutritional Support in Malnourished Patients With Lung Cancer. A. KASPRZYK, K. BILMIN, T. CHMIELEWSKA–IGNATOWICZ, J. PAWLIKOWSKI, U. RELIGIONI, P. MERKS (Warsaw; Lublin; Bydgoszcz, Poland) .................................................................................................................... 53 PCSK9 Antibody-based Treatment Strategies for Patients With Statin Intolerance. E. VOUTYRITSA, C. DAMASKOS, P. FARMAKI, G. KYRIAKOS, E. DIAMANTIS, L.V. QUILES-SÁNCHEZ, A. GARMPI, N. GARMPIS, A. PATSOURAS, A. STELIANIDI, S. SAVVANIS (Athens; Piraeus, Greece; Cartagena; Murcia, Spain) ........................................................................................................................................ 61 Contents continued on the back cover International Journal of Experimental and Clinical Pathophysiology and Drug Research ISSN ( print) : 0258-851X, ISSN ( online) : 1791-7549 Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, Greece. Editorial Board Tel / Fax: +30-22950-53389. e-mail: [email protected]. I. ABRAHAM, Tucson, AZ, USA P. MADARNAS, Sherbrooke, QC, Canada U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, Highlands, NJ, 07732, USA. e-mail: [email protected]. N. J. AGNANTIS, Ioannina, Greece H. MAEDA, Kumamoto, Japan General Policy: IN VIVO is a multidisciplinary journal designed to bring D. ANDERSON, Bradford, West Yorkshire, UK M. MAREEL, Ghent, Belgium together original high quality works and reviews on experimental and clinical V. BARAK, Jerusalem, Israel L. MARGOLIS, Bethesda, MD, USA biomedical research within the frame work of human physiology, pathology M. H. BARCELLOS-HOFF, New York, NY, USA G. MARTORANA, Bologna, Italy and disease management . The topics of IN VIVO include: 1. Experimental K. BEIER, Basel, Switzerland J. MOLN R, Szeged, Hungary development and application of new diagnostic and therapeutic procedures; Á M. BERGQVIST, Uppsala, Sweden S.L. MOOBERRY, San Antonio, TX, USA 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development R. BJERKVIG, Bergen, Norway N. MOTOHASHI, Tokyo, Japan and characterization of models of biomedical research; 5. Cancer diagnosis W. BOWNE, Philadelphia, PA, USA R. M. NAGLER, Haifa, Israel and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; M. CARAGLIA, Naples, Italy S. NAKANO, Fukuoka, Japan 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis; 10. P. CHANDRA, Frankfurt am Main, Germany M. NAKASHIMA, Nagasaki, Japan Retrospective studies and case reports. J.-G. CHUNG, Taichung, Taiwan, ROC M.B. NICHOLL, San Antonio, TX, USA IN VIVO supports : (a) the activities of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH ( IIAR; Kapandriti, Attiki, L. A. COHEN, Northampton, MA, USA K. NILSSON, Uppsala, Sweden Greece) and (b) the organization of the International Conferences of A. I. CONSTANTINOU, Nicosia, Cyprus K. R. NORUM, Oslo, Norway Anticancer Research ( www.iiar-anticancer.org) . T. DALIANIS, Stockholm, Sweden K. OGAWA, Tokyo, Japan Publication Data: IN VIVO is published bimonthly online-only and D. T. DENHARDT, Bridgewater, NJ, USA M. PAG , Laval, QC, Canada É open access by the International Institute of Anticancer Research . Each W. DEN OTTER, Amsterdam, The Netherlands C. POLYCHRONAKOS, Montreal, QC, Canada annual volume comprises six issues. Annual Author and Subject K. DE MEIRLEIR, Brussels, Belgium M.-F. POUPON, Paris, France Indexes are included in the sixth issue of each volume. IN VIVO Vol. 18 (2004) and onwards appears online with HighWire Press. All L. DE RIDDER, Ghent, Belgium D. RADES, L beck, Germany ü published articles are deposited in PubMed Central. E. P. DIAMANDIS, Toronto, ON, Canada F. M. ROBERTSON, Richmond, VA, USA Copyright: Authors retain copyright . The unrestricted non-commercial J.M. DRAKE, New Brunswick, NJ, USA D. RUBELLO, Rovigo, Italy use, distribution and reproduction in any medium of IN VIVO articles for T. EFFERTH, Μainz , Germany C. A. RUBIO, Stockholm, Sweden academic reasons is allowed, provided that the original work is properly W. ENGSTR M, Uppsala, Sweden G. R. RUTTEMAN, Utrecht, The Netherlands cited. The Authors grant the permanent right to the publisher to use any Ö M. ESKELINEN, Kuopio, Finland H. SAKAGAMI, Saitama, Japan articles published in this journal without any restriction, including academic advertising purposes. PDF, XML and HTML files of all articles J. A. FERNANDEZ-POL, Chesterfield, MO, USA G. SAVA, Trieste, Italy published in IN VIVO are the property of the publisher. G. FIORENTINI, Pesaro, Italy D. SCHIFFER, Vercelli, Italy Open Access Policy : Open Access Policy: IN VIVO appears P. B. FISHER, New York, NY, USA L. D. SHULTZ, Bar Harbor, ME, USA bimonthly as an online-only open access journal through the I. FREITAS, Pavia, Italy G. SICA, Rome, Italy Stanford University HighWire Press. Upon acceptance, Authors will M. FRIEDRICH, Krefeld, Germany J. SIEGFRIED, Minneapolis, MN, USA be asked to contribute an online publication fee of US$ 800 for R. E. FRIEDRICH, Hamburg, Germany J. SLANSKY, Denver, CO, USA articles up to 8 online pages (including figures and tables). Each additional excess page will be charged US$ 60,00. Color will not R. GANAPATHI, R. M. SNAPKA, Charlotte, NC, USA Columbus, OH, USA be charged. Authors from developing countries may apply for a V. GORGOULIS, Athens, Greece G.-I. SOMA, Kagawa, Japan 25% discount after the acceptance of their paper. IN VIVO online J. S. GREENBERGER, Pittsburgh, PA, USA P. P. SORDILLO, New York, NY, USA will keep the volume, issue, and page numbering. J. W. GREINER, Bethesda, MD, USA T. A. SPRINGER, Boston, MA, USA Articles in IN VIVO are regulary indexed in bibliographic services, C. J. GRUBBS, Birmingham, AL, USA D. D. SPYROPOULOS, Charleston, SC, USA including Current Contents Life Sciences and Medical Sciences, Index F. GUADAGNI, Rome, Italy K. SYRJ NEN, Helsinki, Finland Medicus, PubMed, PubMed Central, MEDLINE, Biological Abstracts, Ä Chemical Abstracts, BIOSIS Previous, Science Citation Index Expanded, J. HAU, Copenhagen, Denmark G. C. TORRE, Finale Ligure (SV), Italy Essential Science Indicators , Chemical Abstracts, Excerpta Medica, M. HAUER-JENSEN, Little Rock, AR, USA B. TRIBUKAIT, Stockholm, Sweden Elsevier Bibliographic Database, EMBASE, Compendex, GEOBASE, K. S. JEONG, Daegu, S. Korea J. VADGAMA, Los Angeles, CA, USA EMBiology, Elsevier BIOBASE, FLUIDEX, World Textiles, Scopus, M. JHANWAR-UNIYAL, Valhalla, NY, USA J.K. VISHWANATHA, Fort Worth, TX, USA CANCER-LIT Database, University of Sheffield Biomedical Information I. KISS, P cs, Hungary W. WANG, Wolverhampton, UK Service (SUBIS), Current Clinical Cancer, AIDS Abstracts, Progress in é Paliative Care, Update-Research Information Systems Inc., Inpharma- M. KOUTSILIERIS, Athens, Greece N. WATANABE, Sapporo, Japan Reactions Datastar, BRS), Reference Update (I.S.I.), Research Alert , G. R. F. KRUEGER, K ln, Germany W. WEBER, Basel, Switzerland ö Biochemistry & Biophysics Citation (I.S.I.), BioBase, MedBase , Google N. KYPRIANOU, Lexington, KY, USA L. M. WEINER, Washington, DC, USA Scholar, Investigational Drugs Database , VINITI Abstracts Journal, G. LANDBERG, Lund, Sweden J. A. WERNER, Marburg, Germany PubsHub, SIIC Data Bases. J. LEROY, Strasbourg, France S. YL -HERTTUALA, Kuopio, Finland The Editors and Publishers of IN VIVO accept no responsibility for Ä the opinions expressed by the contributors or for the content of W. LICHTENEGGER, Berlin, Germany H. YOSHIDA, Kagoshima, Japan advertisements appearing therein. J. 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