TOXICOLOGICAL PROFILE for HEPTACHLOR and HEPTACHLOR EPOXIDE
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THIALULUMUNIUUS009752019B2 (12 ) United States Patent ( 10 ) Patent No
THIALULUMUNIUUS009752019B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 , 752, 019 B2 Loya Enríquez et al. (45 ) Date of Patent: Sep . 5 , 2017 ( 54 ) COMPOSITE MATERIALS BASED ON 17 /00 ; CO8L 19 / 003; CO8L 75 / 04 ; CO8L RUBBERS , ELASTOMERS , AND THEIR 75 /06 ; CO8L 75 / 08 ; CO8L 75 / 10 ; CO8L RECYCLED 75/ 12 ; CO8L 75 / 14 ; CO8L 75 / 16 ; CO8L 67 / 06 ( 71) Applicants: KAUTEC TECHNOLOGIES, S . A . P . I . DE C . V . , Chihuahua (MX ) ; Centro de USPC 525 / 123 Investigación en Materiales See application file for complete search history . Avanzados , S . C . , Chihuahua (MX ) (72 ) Inventors : René Loya Enríquez, Chihuahua (56 ) References Cited (MX ) ; Grecia Andrea Bueno Herrera , U . S . PATENT DOCUMENTS Chihuahua (MX ) ; Sergio Gabriel Flores Gallardo , Chihuahua (MX ) ; 2 ,879 , 245 A 3 / 1959 Green Erasto Armando Zaragoza Contreras , 2 ,947 , 736 A * 8 / 1960 Lundberg . .. .. .. .. .. .. C08F 16 / 24 526 / 201 Chihuahua (MX ) ; Alejandro Vega 3 ,383 ,351 A * 5 / 1968 Stamberger . .. CO8F 8 / 30 Ríos , Chihuahua (MX ) ; Mónica Elvira 521/ 137 Mendoza Duarte , Chihuahua (MX ) ; 3 ,652 ,467 A 3 / 1972 Bunk et al. Erika Ivonne López Martínez , 3 ,681 , 267 A 8 / 1972 Mayne et al . Chihuahua (MX ) 3 , 801 ,421 A 4 / 1974 Allen et al. 4 ,038 , 341 A * 7 / 1977 Schwartz , Jr . .. .. C08F 299 /04 ( 73 ) Assignees : Kautec Technologies , S . A . P .I De C . V ., 523 /527 Chihuahua (MX ) ; Centro de 4 ,053 , 537 A * 10 / 1977 Ruprecht . .. .. B29D 99/ 0057 521/ 42 Investigacion en Materiales 4 ,244 , 841 A 1/ 1981 Frankland Avanzados, S . C , Chihuahua (MX ) 4 , 327 , 145 A * 4 / 1982 Mitani . -
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Guidelines for Interpretation of the Biological Effects of Selected Constituents in Biota, Water, and Sediment November 1998 NIATIONAL RRIGATION WQATER UALITY P ROGRAM INFORMATION REPORT No. 3 United States Department of the Interior Bureau of Reclamation Fish and Wildlife Service Geological Survey Bureau of Indian Affairs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ntroduction The guidelines, criteria, and other information in The Limitations of This Volume this volume were originally compiled for use by personnel conducting studies for the It is important to note five limitations on the Department of the Interior's National Irrigation material presented here: Water Quality Program (NIWQP). The purpose of these studies is to identify and address (1) Out of the hundreds of substances known irrigation-induced water quality and to affect wetlands and water bodies, this contamination problems associated with any of volume focuses on only nine constituents or the Department's water projects in the Western properties commonly identified during States. When NIWQP scientists submit NIWQP studies in the Western United samples of water, soil, sediment, eggs, or animal States—salinity, DDT, and the trace tissue for chemical analysis, they face a elements arsenic, boron, copper, mercury, challenge in determining the sig-nificance of the molybdenum, selenium, and zinc. -
A COMPARATIVE STUDY of the CYTOGENETIC EFFECTS of the INSECTICIDES HEPTACHLOR, MALATHION, and METHYL PARATHION in Vicia Faba
Contam. Amb. 1, 7-16, 1985 A COMPARATIVE STUDY OF THE CYTOGENETIC EFFECTS OF THE INSECTICIDES HEPTACHLOR, MALATHION, AND METHYL PARATHION IN Vicia faba SANDRAGOMEZ-ARROYO, ANA MAR~ABAIZA, GRA~IELALOPEZ AND RAFAELVILLALOBOS- PIETRINI Laboratorio de Citogenética y Mutagénesis Am- bientales, Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Co- yoacán 04510, México, D. F. y Centro de Inves- tigación y Reproducción Animal, Universidad Au- tónoma de Tlaxcala. ABSTRACT In order to determine the potential cytogenetic effects of Heptachlor, Malathion and Methyl Parathion, meristems of broad bean root tips were treated with se- vera1 concentrations o£ these insecticides for different periods of treatment and recovery. Heptachlor and Malathion induced chromosomal alterations in anaphase cells as fragments and bridges, chromosomes with inactivated centromeres and isochroinosomes, and as micronuclei in interphase cells. Multipolar anaphases also appeared when the mitotic spindle was damaged. Heptachlor induced pycnosis but Malathion did not. Chromosomal aberrations caused by Methyl Parathion were observed in cells only during metaphase, since a strong c-mitotic effect was induced mostly in the form of fragments. Longer recovery periods (42 and 44 h) revealed tetraploid and pycnotic cells. Only in the case of Malation was there an increase in chromosome altera- tions with higher concentrations. However, no such dose response relationship was observed for micronuclei frequency. RESUMEN Con el fin de establecer el daño genético que ocasionan el Heptacloro, el Mala- tión y el Metil Paratión, se realizaron tratamientos sobre las células meristemá- ticas de la raíz de haba con diversas concentraciones de estos insecticidas y dife- rentes tiempos de tratamiento y recuperación. -
Trade Names and Manufacturers
Appendix I Trade names and manufacturers In this appendix, some trade names of various polymeric materials are listed. The list is intended to cover the better known names but it is by no means exhaustive. It should be noted that the names given may or may not be registered. Trade name Polymer Manufacturer Abson ABS polymers B.F. Goodrich Chemical Co. Acrilan Polyacrylonitrile Chemstrand Corp. Acrylite Poly(methyl methacrylate) American Cyanamid Co. Adiprene Polyurethanes E.I. du Pont de Nemours & Co. Afcoryl ABS polymers Pechiney-Saint-Gobain Alathon Polyethylene E.I. du Pont de Nemours & Co. Alkathene Polyethylene Imperial Chemical Industries Ltd. Alloprene Chlorinated natural rubber Imperial Chemical Industries Ltd. Ameripol cis-1 ,4-Polyisoprene B.F. Goodrich Chemical Co. Araldite Epoxy resins Ciba (A.R.L.) Ltd. Arnel Cellulose triacetate Celanese Corp. Arnite Poly(ethylene terephthalate) Algemene Kunstzijde Unie N.Y. Baypren Polychloroprene Farbenfabriken Bayer AG Beetle Urea-formaldehyde resins British Industrial Plastics Ltd. Ben vic Poly(vinyl chloride) Solvay & Cie S.A. Bexphane Polypropylene Bakelite Xylonite Ltd. Butacite Poly( vinyl butyral) E.I. du Pont de Nemours & Co. Butakon Butadiene copolymers Imperial Chemical Industries Ltd. Butaprene Styrene-butadiene copolymers Firestone Tire and Rubber Co. Butvar Poly(vinyl butyral) Shawinigan Resins Corp. Cap ran Nylon 6 Allied Chemical Corp. Carbowax Poly(ethylene oxide) Union Carbide Corp. Cariflex I cis-1 ,4-Polyisoprene Shell Chemical Co. Ltd. Carina Poly(vinyl chloride) Shell Chemical Co. Ltd. TRADE NAMES AND MANUFACTURERS 457 Trade name Polymer Manufacturer Carin ex Polystyrene Shell Chemical Co. Ltd. Celcon Formaldehyde copolymer Celanese Plastics Co. Cellosize Hydroxyethylcellulose Union Carbide Corp. -
Mirex Group: 04
DaMocles WiSe 19/20: Mirex Group: 04 Marius Wollrab Milan Zengeler Maurice Wingsheim February 2, 2020 Contents 1. General information 1 2. Synthesis 2 3. Toxicology 2 4. Ban 3 II. References I I 1. General information Mirex, Dechlorane or Perchloropentacyclodecane (figure 1) is a synthetic produced, white, odorless, crystalline solid chlorinated hydrocarbon. The IUPAC name is: 1,1a,2,2,3,3a,4,5,5,5a,5b,6- dodecachlorooctahydro-1H-1,3,4-(methanetriyl)cyclobuta[cd]pentalene and the GHS classification is depicted in figure 2. Figure 1: Structure of Mirex [1] Figure 2: GHS Classification [2] 1 Chemical and physical properties: Property name Property value 1 Molecular weight 545,5 g mol− 1 Exact mass 545,617 382 g mol− Melting point 485 ◦C Chemical formula C10Cl12 CAS-Nr. 2385-85-5 Mirex was commonly used as a stomach insecticide against imported fire ants Solenopsis saevissima richteri and as a fire-retardant for plastics, paper, electronics and paint. As a fire-retardant, Mirex was sold underthe name of Dechlorane. The top producer of Mirex was the USA and up to 75% were exported to country’s in south and middle America.[2] 2. Synthesis Mirex can be synthesized by dimerization of hexachlorocyclopentadiene (figure 3). For this reaction aluminiumchloride is used as catalyst. Figure 3: Synthesis of Mirex 3. Toxicology Mirex targets and damages the liver, kidney, eye, thyroid, central nervous system and the reproductive organs. Studies on laboratory animals have caused it to be classified as a possible human carcinogen.[3] 2 Mirex is also dangerous for humans and the environment, because of the risk of bioaccumulation. -
Annex XV Report
Annex XV report PROPOSAL FOR IDENTIFICATION OF A SUBSTANCE OF VERY HIGH CONCERN ON THE BASIS OF THE CRITERIA SET OUT IN REACH ARTICLE 57 Substance Name(s): 1,6,7,8,9,14,15,16,17,17,18,18- Dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene (“Dechlorane Plus”TM) [covering any of its individual anti- and syn-isomers or any combination thereof] EC Number(s): 236-948-9; -; - CAS Number(s): 13560-89-9; 135821-74-8; 135821-03-3 Submitted by: United Kingdom Date: 29 August 2017 ANNEX XV – IDENTIFICATION OF DECHLORANE PLUS AS SVHC CONTENTS PROPOSAL FOR IDENTIFICATION OF A SUBSTANCE OF VERY HIGH CONCERN ON THE BASIS OF THE CRITERIA SET OUT IN REACH ARTICLE 57..........................................................................................IV PART I ...............................................................................................................................................1 JUSTIFICATION ..................................................................................................................................1 1. IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES ...................................2 1.1 Name and other identifiers of the substance................................................................................2 1.2 Composition of the substance ........................................................................................................2 1.3 Identity and composition of degradation products/metabolites relevant for the SVHC assessment ....................................................................................................................................3 -
Pesticide Residue Monitoring in Sediment and Surface Water Within the South Florida Water Management District Volume 2
Technical Publication 91-01 Pesticide Residue Monitoring in Sediment and Surface Water Within the South Florida Water Management District Volume 2 by Richard J. Pfeuffer January 1991 This publication was produced at an annual cost of $243.75 or $.49 per copy to inform the public. 500 191 Produced on recycled paper. Water Quality Division Research and Evaluation Department South Florida Water Management District West Palm Beach, Florida A IBSTRAC'I' Pesticide monitoring data are collected under the requirements of several permits and agreements as an indicator of water quality. The monitoring provides data to determine shifts or adverse trends in the quality of water being delivered to Lake Okeechobee, Everglades National Park, and the Water Conservation Areas. In addition, pesticide residue data are collected throughout the South Florida Water Management District at locations selected to determine water quality conditions at the major water control points. Special investigations are performed on selected pesticides as required and follow-up sampling is conducted based on the pesticides detected. Data were collected from 13 stations in 1984. By 1988, the network was expanded to 29 stations. Currently, water and sediment samples are collected quarterly and analyzed for 67 pesticides, herbicides and degradation products. Out of a total of 197 surface water samples, 13 percent had detectable residues, while 25 percent of the 208 sediment samples had detectable residues. The compounds detected in the water samples included atrazine and zinc phosphide while a variety of compounds, including DDT, have been detected in the sediment. None of the residues detected are considered to have adverse health or environmental effects. -
Past Use of Chlordane, Dieldrin, And
The Hazard Evaluation and Emergency Response Office (HEER Office) is part of the Hawai‘i Department of Health (HDOH) Environmental Health Administration, whose mission is to protect human health and the environment. The HEER Office provides leadership, support, and partnership in preventing, planning for, responding to, and enforcing environmental laws relating to releases or threats of releases of hazardous substances. Past Use of Chlordane, Dieldrin, and other Organochlorine Pesticides for Termite Control in Hawai‘i: Safe Management Practices around Treated Foundations or during Building Demolition This fact sheet provides building owners, demolition and construction contractors, developers, realtors, and others with an overview of the potential environmental concerns associated with the past use of organochlorine termiticides (pesticides used to control termites) in Hawai‘i. In addition, this fact sheet discusses methods for reducing exposure to organochlorine termiticides during building demolition or around the foundations of treated buildings and identifies resources for further information. What are organochlorine termiticides? Organochlorine termiticides are a group of pesticides that were used for termite control in and around wooden buildings and homes from the mid-1940s to the late 1980s. These organochlorine pesticides included chlordane, aldrin, dieldrin, heptachlor, and dichlorodiphenyltrichloroethane (DDT). They were used primarily by pest control operators in Hawaii’s urban areas, but also by homeowners, the military, the state, and counties to protect buildings against termite damage. In the 1970s and 1980s, the U.S. Environmental Protection Agency (EPA) banned all uses of these organochlorine pesticides except for heptachlor, which can be used today only for control of fire ants in underground power transformers. -
P-Listed Hazardous Wastes
P-Listed Hazardous Wastes The Environmental Protection Agency (EPA) has identified a number of chemicals on the EPA “P-list” that present an especially acute hazard when disposed of as hazardous waste. Because of their acute hazards, there are more stringent requirements when disposing of these wastes: ►Container size: When collecting p-listed chemicals as waste, the volume of the hazardous waste container must not exceed one quart (approximately one liter). ►Empty containers: Empty containers that held p-listed chemicals must also be disposed of as hazardous waste. They are not allowed to be washed or re-used. ►Contaminated materials: Disposable materials that become contaminated with p-listed chemicals (e.g. gloves, weighing boats, etc.) must also be disposed of as hazardous waste. Non-disposable materials must be “triple-rinsed”, or rinsed three times to remove the contamination. This rinsate must be collected as hazardous waste. Materials contaminated with p-listed chemicals may not be washed or re-used until they have been triple-rinsed. Remember: - Label the waste as hazardous waste. Most common p-listed wastes Just like all other hazardous wastes, p-listed Chemical CAS number wastes must be labeled with the words Acrolein 107–02–8 “hazardous waste”, the complete chemical Allyl alcohol 107–18–6 name, and the associated hazard Arsenic compounds Varies characteristics (e.g., ignitable, corrosive, Inorganic cyanide Varies toxic, or reactive). salts Carbon disulfide 75-15-0 - Use disposable materials whenever Cyanogen and 460-19-5, 506-77-4 possible. Triple-rising non-disposable Cyanogen Chloride material generates a lot of waste, which can 2,4-Dinitrophenol 51–28–5 be difficult to dispose of safely. -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime. -
Chlorendic Acid in 1977 (TSCA 1979)
SUBSTANCE PROFILES importer of chlorendic acid in 1977 (TSCA 1979). The Chlorendic Acid manufacturer/importer reported zero production, but the TSCA CAS No. 115-28-6 Inventory estimated that 3 million to 30 million lb of chlorendic acid were produced or imported in 1977. No data on chlorendic Reasonably anticipated to be a human carcinogen acid exports were available. First Listed in the Fifth Annual Report on Carcinogens (1989) Exposure Cl O The primary route of potential human exposure to chlorendic acid is Cl C dermal contact, while some small exposure may possibly occur OH through inhalation. It is manufactured in an essentially closed system Cl C O which would seem to minimize, although not eliminate, potential Cl Cl C occupational exposure during the manufacturing process (NTP 1987). Cl OH When used as a reactive flame-retardant or hardening agent, chlorendic acid bonds covalently to the polymer, resulting in less Carcinogenicity potential for human exposure. In its uses as an extreme pressure Chlorendic acid is reasonably anticipated to be a human carcinogen based lubricant and a chemical intermediate, there is the possibility of on sufficient evidence of carcinogenicity in experimental animals (NTP human exposure to chlorendic acid. Chlorendic acid was not listed in 1987). When administered in the diet, the compound was the National Occupational Exposure Survey, conducted by NIOSH carcinogenic in male mice and in rats of both sexes. In male rats, from 1981 to 1983; however, it was included in the National chlorendic acid caused neoplastic nodules of the liver and acinar cell Occupational Hazard Survey (NOHS) conducted by NIOSH from adenomas of the pancreas. -
Download in English
UNITED NATIONS BC UNEP/CHW.12/5/Add.9 Distr.: General 10 July 2015 Original: English Conference of the Parties to the Basel Convention on the Control of Transboundary Movements of Hazardous Wastes and Their Disposal Twelfth meeting Geneva, 4–15 May 2015 Agenda item 4 (b) (i) Matters related to the implementation of the Convention: scientific and technical matters: technical guidelines Technical guidelines Technical guidelines on the environmentally sound management of wastes consisting of, containing or contaminated with the pesticides aldrin, alpha hexachlorocyclohexane, beta hexachlorocyclohexane, chlordane, chlordecone, dieldrin, endrin, heptachlor, hexachlorobenzene, lindane, mirex, pentachlorobenzene, perfluorooctane sulfonic acid, technical endosulfan and its related isomers or toxaphene or with hexachlorobenzene as an industrial chemical Note by the Secretariat At its twelfth meeting, the Conference of the Parties to the Basel Convention on the Control of Transboundary Movements of Hazardous Wastes and Their Disposal adopted, in decision BC-12/3 on technical guidelines on the environmentally sound management of wastes consisting of, containing or contaminated with persistent organic pollutants, the technical guidelines on the environmentally sound management of wastes consisting of, containing or contaminated with the pesticides aldrin, alpha hexachlorocyclohexane, beta hexachlorocyclohexane, chlordane, chlordecone, dieldrin, endrin, heptachlor, hexachlorobenzene, lindane, mirex, pentachlorobenzene, perfluorooctane sulfonic acid, technical endosulfan and its related isomers or toxaphene or with hexachlorobenzene as an industrial chemical, on the basis of the draft technical guidelines contained in document UNEP/CHW.12/INF/15. The technical guidelines referred to above were prepared by the Food and Agriculture Organization of the United Nations as lead organization for this work taking into account comments received from members of the small intersesssional working group on persistent organic pollutants wastes by 27 March 2015.