General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Brown, Emery N., Patrick L. Purdon, and Christa J. Van Dort. “General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis.” Annual Review of Neuroscience 34, no. 1 (July 21, 2011): 601–628. As Published http://dx.doi.org/10.1146/annurev-neuro-060909-153200 Publisher Annual Reviews Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/86331 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ NIH Public Access Author Manuscript Annu Rev Neurosci. Author manuscript; available in PMC 2012 July 06. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Annu Rev Neurosci. 2011 ; 34: 601–628. doi:10.1146/annurev-neuro-060909-153200. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis Emery N. Brown1,2,3, Patrick L. Purdon1,2, and Christa J. Van Dort1,2 Emery N. Brown:
[email protected]; Patrick L. Purdon:
[email protected]; Christa J. Van Dort:
[email protected] 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Abstract Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures.