Enhanced Warfighters: Risk, Ethics, and Policy
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Use of Unapproved Products, Off-Label Use, and Black-Box Warning
Use of Unapproved Products, Off-Label Use, and Black-Box Warning ... A Variation of Newton’s Third Law or the Practical Application of the Rule of Unin- tended Consequences … Considerations in Military Operational Medicine Jerome F. Pierson, RPh, PhD Executive Editors Note: As multiple medical research and development efforts (both in SOF and in conventional research units) offer new drugs and medical equipment to the battlefield, we need to understand the rules of engagement for use, which, are dif- ferent for individual providers versus military heath care systems. ABSTRACT This article discusses the regulatory requirements for the use of unapproved drugs and off-label use of drugs and provides specific examples for military medicine. Additionally, it explains issues associated with standardization by the Service as a designated set, kit, or outfit as opposed to a general guidance. The former situation can be interpreted as a de facto policy whereas the latter is an adaptation of practice of medicine. Recent news stories brought to light the challenges assaulted from many sides to include consumer groups who facing military medicine in an environment where dramatic at times advocate for greater safety and at other times de- life-saving measures have become the expected rather then mand quicker access to therapeutic breakthroughs as well the exception.1,2 However, many of these same life-saving as the pharmaceutical industry which faces demands from measures have the potential to place a practitioner in situa- stockholders for return on investment. Reliance upon re- tions of “damned if you do, damned if you don’t” with re- sults from controlled clinical trials is problematic in that it gard to adherence to various regulatory and legal hurdles. -
The History Group's Silver Jubilee
History of Meteorology and Physical Oceanography Special Interest Group Newsletter 1, 2010 ANNUAL REPORT CONTENTS We asked in the last two newsletters if you Annual Report ........................................... 1 thought the History Group should hold an Committee members ................................ 2 Annual General Meeting. There is nothing in Mrs Jean Ludlam ...................................... 2 the By-Law s or Standing Orders of the Royal Meteorological Society that requires the The 2010 Summer Meeting ..................... 3 Group to hold one, nor does Charity Law Report of meeting on 18 November .......... 4 require one. Which papers have been cited? .............. 10 Don’t try this at home! ............................. 10 Only one person responded, and that was in More Richard Gregory reminiscences ..... 11 passing during a telephone conversation about something else. He was in favour of Storm warnings for seafarers: Part 2 ....... 13 holding an AGM but only slightly so. He Swedish storm warnings ......................... 17 expressed the view that an AGM provides an Rikitea meteorological station ................. 19 opportunity to put forward ideas for the More on the D-Day forecast .................... 20 Group’s committee to consider. Recent publications ................................ 21 As there has been so little response, the Did you know? ........................................ 22 Group’s committee has decided that there will Date for your diary .................................. 23 not be an AGM this year. Historic picture ........................................ 23 2009 members of the Group ................... 24 CHAIRMAN’S REVIEW OF 2009 by Malcolm Walker year. Sadly, however, two people who have supported the Group for many years died during I begin as I did last year. Without an enthusiastic 2009. David Limbert passed away on 3 M a y, and conscientious committee, there would be no and Jean Ludlam died in October (see page 2). -
Cumulated Bibliography of Biographies of Ocean Scientists Deborah Day, Scripps Institution of Oceanography Archives Revised December 3, 2001
Cumulated Bibliography of Biographies of Ocean Scientists Deborah Day, Scripps Institution of Oceanography Archives Revised December 3, 2001. Preface This bibliography attempts to list all substantial autobiographies, biographies, festschrifts and obituaries of prominent oceanographers, marine biologists, fisheries scientists, and other scientists who worked in the marine environment published in journals and books after 1922, the publication date of Herdman’s Founders of Oceanography. The bibliography does not include newspaper obituaries, government documents, or citations to brief entries in general biographical sources. Items are listed alphabetically by author, and then chronologically by date of publication under a legend that includes the full name of the individual, his/her date of birth in European style(day, month in roman numeral, year), followed by his/her place of birth, then his date of death and place of death. Entries are in author-editor style following the Chicago Manual of Style (Chicago and London: University of Chicago Press, 14th ed., 1993). Citations are annotated to list the language if it is not obvious from the text. Annotations will also indicate if the citation includes a list of the scientist’s papers, if there is a relationship between the author of the citation and the scientist, or if the citation is written for a particular audience. This bibliography of biographies of scientists of the sea is based on Jacqueline Carpine-Lancre’s bibliography of biographies first published annually beginning with issue 4 of the History of Oceanography Newsletter (September 1992). It was supplemented by a bibliography maintained by Eric L. Mills and citations in the biographical files of the Archives of the Scripps Institution of Oceanography, UCSD. -
13Th International Conference on Cyber Conflict: Going Viral 2021
2021 13th International Conference on Cyber Confict: Going Viral T. Jančárková, L. Lindström, G. Visky, P. Zotz (Eds.) 2021 13TH INTERNATIONAL CONFERENCE ON CYBER CONFLICT: GOING VIRAL Copyright © 2021 by NATO CCDCOE Publications. All rights reserved. IEEE Catalog Number: CFP2126N-PRT ISBN (print): 978-9916-9565-4-0 ISBN (pdf): 978-9916-9565-5-7 COPYRIGHT AND REPRINT PERMISSIONS No part of this publication may be reprinted, reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission of the NATO Cooperative Cyber Defence Centre of Excellence ([email protected]). This restriction does not apply to making digital or hard copies of this publication for internal use within NATO, or for personal or educational use when for non-proft or non-commercial purposes, providing that copies bear this notice and a full citation on the frst page as follows: [Article author(s)], [full article title] 2021 13th International Conference on Cyber Confict: Going Viral T. Jančárková, L. Lindström, G. Visky, P. Zotz (Eds.) 2021 © NATO CCDCOE Publications NATO CCDCOE Publications LEGAL NOTICE: This publication contains the opinions of the respective authors only. They do not Filtri tee 12, 10132 Tallinn, Estonia necessarily refect the policy or the opinion of NATO Phone: +372 717 6800 CCDCOE, NATO, or any agency or any government. NATO CCDCOE may not be held responsible for Fax: +372 717 6308 any loss or harm arising from the use of information E-mail: [email protected] contained in this book and is not responsible for the Web: www.ccdcoe.org content of the external sources, including external websites referenced in this publication. -
Free Executive Summary
Giving Full Measure to Countermeasures: Addressing Problems in the DoD Program to Develop Medical Countermeasures Against Biological Warfare Agents http://www.nap.edu/catalog/10908.html Committee on Accelerating the Research, Development, and Acquisition of Medical Countermeasures Against Biological Warfare Agents Medical Follow-up Agency and Board on Life Sciences Lois M. Joellenbeck, Jane S. Durch, and Leslie Z. Benet, Editors Copyright © National Academy of Sciences. All rights reserved. Giving Full Measure to Countermeasures: Addressing Problems in the DoD Program to Develop Medical Countermeasures Against Biological Warfare Agents http://www.nap.edu/catalog/10908.html THE NATIONAL ACADEMIES PRESS 500 Fifth Street, N.W. Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the Na- tional Academy of Sciences, the National Academy of Engineering, and the Institute of Medi- cine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. Support for this project was provided by Contract No. DAMD17-02-C-0099 between the National Academy of Sciences and the U.S. Army. The views presented in this report are those of the Institute of Medicine and National Research Council Committee on Accelerat- ing the Research, Development, and Acquisition of Medical Countermeasures Against Bio- logical Warfare Agents and are not necessarily those of the funding agencies. Library of Congress Cataloging-in-Publication Data Giving full measure to countermeasures : addressing problems in the DOD program to de- velop medical countermeasures against biological warfare agents / Committee on Acceler- ating the Research, Development, and Acquisition of Medical Countermeasures against Bio- logical Warfare Agents, Medical Follow-up Agency and Board on Life Sciences ; Lois M. -
Medical Management of Biologic Casualties Handbook
USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Fourth Edition February 2001 U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES ¨ FORT DETRICK FREDERICK, MARYLAND 1 Sources of information: National Response Center 1-800-424-8802 or (for chem/bio hazards & terrorist events) 1-202-267-2675 National Domestic Preparedness Office: 1-202-324-9025 (for civilian use) Domestic Preparedness Chem/Bio Help line: 1-410-436-4484 or (Edgewood Ops Center - for military use) DSN 584-4484 USAMRIID Emergency Response Line: 1-888-872-7443 CDC'S Bioterrorism Preparedness and Response Center: 1-770-488-7100 John's Hopkins Center for Civilian Biodefense: 1-410-223-1667 (Civilian Biodefense Studies) An Adobe Acrobat Reader (pdf file) version and a Palm OS Electronic version of this Handbook can both be downloaded from the Internet at: http://www.usamriid.army.mil/education/bluebook.html 2 USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Fourth Edition February 2001 Editors: LTC Mark Kortepeter LTC George Christopher COL Ted Cieslak CDR Randall Culpepper CDR Robert Darling MAJ Julie Pavlin LTC John Rowe COL Kelly McKee, Jr. COL Edward Eitzen, Jr. Comments and suggestions are appreciated and should be addressed to: Operational Medicine Department Attn: MCMR-UIM-O U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick, Maryland 21702-5011 3 PREFACE TO THE FOURTH EDITION The Medical Management of Biological Casualties Handbook, which has become affectionately known as the "Blue Book," has been enormously successful - far beyond our expectations. Since the first edition in 1993, the awareness of biological weapons in the United States has increased dramatically. -
A 1 Case-PR/ }*Rciofft.;Is Report
.A 1 case-PR/ }*rciofft.;is Report (a) This eruption site on Mauna Loa Volcano was the main source of the voluminous lavas that flowed two- thirds of the distance to the town of Hilo (20 km). In the interior of the lava fountains, the white-orange color indicates maximum temperatures of about 1120°C; deeper orange in both the fountains and flows reflects decreasing temperatures (<1100°C) at edges and the surface. (b) High winds swept the exposed ridges, and the filter cannister was changed in the shelter of a p^hoehoc (lava) ridge to protect the sample from gas contamination. (c) Because of the high temperatures and acid gases, special clothing and equipment was necessary to protect the eyes. nose, lungs, and skin. Safety features included military flight suits of nonflammable fabric, fuil-face respirators that are equipped with dual acidic gas filters (purple attachments), hard hats, heavy, thick-soled boots, and protective gloves. We used portable radios to keep in touch with the Hawaii Volcano Observatory, where the area's seismic activity was monitored continuously. (d) Spatter activity in the Pu'u O Vent during the January 1984 eruption of Kilauea Volcano. Magma visible in the circular conduit oscillated in a piston-like fashion; spatter was ejected to heights of 1 to 10 m. During this activity, we sampled gases continuously for 5 hours at the west edge. Cover photo: This aerial view of Kilauea Volcano was taken in April 1984 during overflights to collect gas samples from the plume. The bluish portion of the gas plume contained a far higher density of fine-grained scoria (ash). -
The President
3 1999 Compilation and Parts 100±102 Revised as of January 1, 2000 The President Published by: Office of the Federal Register National Archives and Records Administration A Special Edition of the Federal Register VerDate 11-MAY-2000 08:53 Aug 11, 2000 Jkt 190004 PO 00000 Frm 00001 Fmt 8091 Sfmt 8091 Y:\SGML\190004F.XXX pfrm07 PsN: 190004F U.S. GOVERNMENT PRINTING OFFICE WASHINGTON: 2000 For sale by U.S. Government Printing Office Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402±9328 ii VerDate 11-MAY-2000 08:53 Aug 11, 2000 Jkt 190004 PO 00000 Frm 00002 Fmt 8092 Sfmt 8092 Y:\SGML\190004F.XXX pfrm07 PsN: 190004F Table of Contents Page List of Title 3 Compilations ....................................................................... iv Explanation of the Code of Federal Regulations ........................................... v Explanation of This Title ........................................................................... ix How To Cite This Title ............................................................................... xi Title 3 ......................................................................................................... xiii 1999 CompilationÐPresidential Documents .................................... 1 Chapter IÐExecutive Office of the President .................................. 325 Title 3 Finding Aids .................................................................................... 335 Tables ............................................................................................. -
General Anesthesia and Altered States of Arousal: a Systems Neuroscience Analysis
General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Brown, Emery N., Patrick L. Purdon, and Christa J. Van Dort. “General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis.” Annual Review of Neuroscience 34, no. 1 (July 21, 2011): 601–628. As Published http://dx.doi.org/10.1146/annurev-neuro-060909-153200 Publisher Annual Reviews Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/86331 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ NIH Public Access Author Manuscript Annu Rev Neurosci. Author manuscript; available in PMC 2012 July 06. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Annu Rev Neurosci. 2011 ; 34: 601–628. doi:10.1146/annurev-neuro-060909-153200. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis Emery N. Brown1,2,3, Patrick L. Purdon1,2, and Christa J. Van Dort1,2 Emery N. Brown: [email protected]; Patrick L. Purdon: [email protected]; Christa J. Van Dort: [email protected] 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Abstract Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. -
Development of DLC-Coated Solid Sialon/Tin Ceramic End Mills for Nickel Alloy Machining: Problems and Prospects
coatings Article Development of DLC-Coated Solid SiAlON/TiN Ceramic End Mills for Nickel Alloy Machining: Problems and Prospects Sergey N. Grigoriev , Marina A. Volosova *, Sergey V. Fedorov, Anna A. Okunkova , Petr M. Pivkin , Pavel Y. Peretyagin and Artem Ershov Department of High-Efficiency Processing Technologies, Moscow State University of Technology “STANKIN”, Vadkovskiy per. 3A, 127055 Moscow, Russia; [email protected] (S.N.G.); [email protected] (S.V.F.); [email protected] (A.A.O.); [email protected] (P.M.P.); [email protected] (P.Y.P.); [email protected] (A.E.) * Correspondence: [email protected]; Tel.: +7-916-308-49-00 Abstract: The study is devoted to the development and testing of technological principles for the manufacture of solid end mills from ceramics based on a powder composition of α-SiAlON, β-SiAlON, and TiN additives, including spark plasma sintering powder composition, diamond sharpening of sintered ceramic blanks for shaping the cutting part of mills and deposition of anti- friction Si-containing diamond-like carbon (DLC) coatings in the final stage. A rational relationship between the components of the powder composition at spark plasma sintering was established. The influence of optimum temperature, which is the most critical sintering parameter, on ceramic samples’ basic physical and mechanical properties was investigated. DLC coatings’ role in changing the surface properties of ceramics based on SiAlON, such as microrelief, friction coefficient, et cetera, was studied. A comparative analysis of the efficiency of two tool options, such as developed samples of experimental mills made of SiAlON/TiN and commercial samples ceramic mills based on SiAlON, Citation: Grigoriev, S.N.; Volosova, doped with stabilizing additives containing Yb when processing nickel alloys (NiCr20TiAl alloy was M.A.; Fedorov, S.V.; Okunkova, A.A.; used as an example). -
“Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014
1 “Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014 2 “We all know we must die. But that, say the immortalists, is no longer true… Science has progressed so far that we are morally bound to seek solutions, just as we would be morally bound to prevent a real tsunami if we knew how” - Bryan Appleyard 1 “The moral argument for cryonics is that it's wrong to discontinue care of an unconscious person when they can still be rescued. This is why people who fall unconscious are taken to hospital by ambulance, why they will be maintained for weeks in intensive care if necessary, and why they will still be cared for even if they don't fully awaken after that. It is a moral imperative to care for unconscious people as long as there remains reasonable hope for recovery.” - ALCOR 2 “How many cryonicists does it take to screw in a light bulb? …None – they just sit in the dark and wait for the technology to improve” 3 - Sterling Blake 1 Appleyard 2008. Page 22-23 2 Alcor.org: ‘Frequently Asked Questions’ 2014 3 Blake 1996. Page 72 3 Introduction Biologists have known for some time that certain organisms can survive for sustained time periods in what is essentially a death"like state. The North American Wood Frog, for example, shuts down its entire body system in winter; its heart stops beating and its whole body is frozen, until summer returns; at which point it thaws and ‘comes back to life’ 4. -
Apollo Over the Moon: a View from Orbit (Nasa Sp-362)
chl APOLLO OVER THE MOON: A VIEW FROM ORBIT (NASA SP-362) Chapter 1 - Introduction Harold Masursky, Farouk El-Baz, Frederick J. Doyle, and Leon J. Kosofsky [For a high resolution picture- click here] Objectives [1] Photography of the lunar surface was considered an important goal of the Apollo program by the National Aeronautics and Space Administration. The important objectives of Apollo photography were (1) to gather data pertaining to the topography and specific landmarks along the approach paths to the early Apollo landing sites; (2) to obtain high-resolution photographs of the landing sites and surrounding areas to plan lunar surface exploration, and to provide a basis for extrapolating the concentrated observations at the landing sites to nearby areas; and (3) to obtain photographs suitable for regional studies of the lunar geologic environment and the processes that act upon it. Through study of the photographs and all other arrays of information gathered by the Apollo and earlier lunar programs, we may develop an understanding of the evolution of the lunar crust. In this introductory chapter we describe how the Apollo photographic systems were selected and used; how the photographic mission plans were formulated and conducted; how part of the great mass of data is being analyzed and published; and, finally, we describe some of the scientific results. Historically most lunar atlases have used photointerpretive techniques to discuss the possible origins of the Moon's crust and its surface features. The ideas presented in this volume also rely on photointerpretation. However, many ideas are substantiated or expanded by information obtained from the huge arrays of supporting data gathered by Earth-based and orbital sensors, from experiments deployed on the lunar surface, and from studies made of the returned samples.