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The Erythrasma Microorganism in Situ: Studies Using the Skin Surface Biopsy Technique

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The Erythrasma Microorganism in Situ: Studies Using the Skin Surface Biopsy Technique J Clin Pathol: first published as 10.1136/jcp.25.9.799 on 1 September 1972. Downloaded from J. clin. Path., 1972, 25, 799-803 The erythrasma microorganism in situ: studies using the skin surface biopsy technique R. MARKS, N. D. RAMNARAIN, B. BHOGAL, AND N. T. MOORE From the Institute of Dermatology, St. John's Hospital for Diseases of the Skin, London, and the Depart- ment of Crystallography, Birkbeck College, London SYNOPSIS The skin surface biopsy technique has been used to investigate the erythrasma organism in situ in the stratum corneum in 11 patients. Staining by PAS and Gram stain showed the presence of a large number of organisms arranged haphazardly in some areas and in microcolonies in others. With the scanning electron microscope it was possible to see that smooth filamentous chains of microorganisms had penetrated horn cells and caused disturbance of the surface structure of these cells. Enzyme histochemical tests showed that the erythrasma microorganism possessed a strong react- ivity for NAD diaphorase and other mitochondrial enzymes. The reactivity was focal confirming a complex subcellular organization of organelles. It is suggested that the erythrasma microorganism secretes a mucopolysaccharide sheath in some circumstances. copyright. Erythrasma is a chronic scaly dermatosis affecting all 11 patients were men, the average age was 48 and the body flexures and intertriginous areas of adults. the age range 24 to 63. In nine the groins were Previously it was believed to be due either to a type involved, in four the toe webs were involved, and in of dermatophyte (Microsporum minutissimum) or an four the axillae were involved. It can be seen that the actinomycete (Nocardia minutissimum). In 1969, a usual male predominance of the disease is evident diphtheroid termed Corynebacterium minutissimum in our group of patients. A coral pink fluorescence was isolated from lesions of erythrasma and thought was detected in the involved sites when they were http://jcp.bmj.com/ to be the causative agent (Sarkany, Taplin, and viewed in ultraviolet light and small fluorescing Blank, 1961). Still more recently Somerville (1970) colonies of C. minutissimum were isolated on 199 suggested that several strains of fluorescent diphther- plates from skin scales in all patients. oid organisms were responsible for the clinical disorder that is recognized as erythrasma. In this SKIN SURFACE BIOPSIES study we describe the results of our investigations These specimens were obtained using ethyl cyano- into the causative organism of erythrasma using the acrylate of the (Permabond, Staines, Middx). Drops on October 6, 2021 by guest. Protected skin surface biopsy technique, which removes an adhesive were placed on glass microscope slides or intact layer of stratum corneum with a cyano- coverslips. Samples taken onto coverslips were acrylate adhesive (Marks and Dawber, 1971). A stored in the deep freeze at -40'C before histo- general account of the use of this method for chemical examination. Samples on microscope slides demonstrating pathogenic microorganisms in the were examined by light microscopy after alcohol stratum corneum is documented elsewhere (Marks fixation (two minutes) and staining with periodic and Dawber, 1972). acid Schiff reagent (periodic acid 10 minutes, Schiff reagent 20 minutes) or Gram stain (methyl Methods violet two minutes, Gram's iodine two minutes, with differentiation in equal parts of alcohol and acetone PATIENTS for four seconds and counterstaining in neutral red The clinical details of the 11 patients with erythrasma two minutes). These preparations were made per- who were investigated in this study are as follows: manent by mounting them with a coverslip and Received for publication 8 June 1972. neutral mounting medium. 799 J Clin Pathol: first published as 10.1136/jcp.25.9.799 on 1 September 1972. Downloaded from 800 R. Marks, N. D. Ramnairaini, B. Bhogal, and N. T. Moore ENZYME HISTOCHEMICAL INVESTIGATIONS Enzyme No. No. No Futngus Total Skin surface biopsies from six patients were taken Activity Positive Negative onto coverslips instead of microscope slides and were Tested tested with the following enzyme histochemical Non-specific 4 0 1 5 reactions: (a) non-specific esterase (indoxyl acetate esterase Leucine 1 1 0 2 esterase method of Holt, 1954); (b) leucine amino- amino peptidase (sing L-leucyl 4 methoxy - naphthyla- peptidase as method of NAD 5 0 0 5 mide substrate and the Nachlas, diaphorase Crawford, and Seligman, 1957); (c) NAD diaphorase, Lactic 4 0 1 5 lactic dehydrogenase, succinic dehydrogenase, and dehydro- genase beta-hydroxybutyric dehydrogenase (using NBT ATPase I 0 0 1 method of Pearse, 1960); and (d) adenosine tri- Succinic 2 0 2 dehydro- phosphatase (using method ofWachstein, Meisel,and genase Niedzwiedz, 1960). 3-Hydroxy- 2 0 0 2 butyric dehydro- SCANNING ELECTRON MICROSCOPE STUDIES genase Skin surface biopsies from three of the subjects were taken onto glass microscope slides. Areas from the Table I Summary of the results of the enzyme histo- specimen-bearing sites of these slides were cut to chemical tests size, mounted on 'stubs', and then coated with carbon in an Edwards coating unit. The coated specimens were then viewed in a Cambridge sizes present (Fig. 3). The chains were formed by the stereoscan scanning electron microscope (SEM) at an apparent linking of several organisms. It is interesting accelerating voltage of 20kv at a 45° tilt. to note that although individual bacteria were easily seen when they were isolated or single cells, it was Results only just possible to make out the shape of the individual microorganisms when they were arrangedcopyright. Skin surface biopsies from the affected sites stained in a chain. The surface of the bacterial cells appeared with PAS reagent or Gram stain demonstrated the regularly smooth without any obvious specialized presence of numerous fusiform microorganisms anatomical features at magnifications up to 25 000. which were arranged in clusters, chains, or singly, The number of organisms seen by SEM was small and scattered over variously sized areas (Figs. 1 a and compared to the large number seen in similar pre- b). The chains that were seen usually comprised parations viewed with the light microscope after three, four, or occasionally more, individual staining. The chains of bacterial cells were frequently bacterial cells. The microorganisms appeared seen to be penetrating the cornified cells. At the site ofhttp://jcp.bmj.com/ approximately three to four times as long as they penetration there were, in several scales, openings were broad. With the PAS stain there was noticeable that were two or three times larger than the diameter diffuse staining of the sites containing the micro- of the microorganisms. organisms which was visible macroscopically. There The involved cells of the stratum corneum had an did not appear to be a particular accentuation around irregular ridge pattern, mainly composed of hair follicles or sweat gland openings. low, broken, undulating ridges which sometimes The results of the enzyme histochemical in- branched. The surrounding uninvolved cells often on October 6, 2021 by guest. Protected vestigations are given in Table 1. It can be seen that possessed prominent villi resembling the surface these bacteria possess a wide range of enzyme structure of the scale in psoriasis and some other reactivities. Mitochondrial enzyme activities seemed parakeratotic disorders (Dawber, Marks, and Swift, particularly strong, especially NAD diaphorase and 1972). lactic dehydrogenase activities. The reaction pro- ducts from the tests performed were not distributed Comment diffusely within the individual bacterial cells, but appeared aggregated in well defined foci within each The skin surface biopsy method is well suited to the cell (Fig. 2). study of certain aspects of the microbiology of the With the SEM single rod-shaped and oval struc- skin. In particular, a good view is obtained of various tures and chains were seen lying on, and embedded invading microorganisms in their 'natural habitat' in, the surface of the individual cornified cells. so that the invasive process can be studied. In Individual bacterial cells measured approximately addition, the number of pathogens present can be 2, x 1Is although there was quite a wide range of directly estimated and it is also possible to observe J Clin Pathol: first published as 10.1136/jcp.25.9.799 on 1 September 1972. Downloaded from The erythrasma microorganism in situ: studies using the skin surface biopsy technique 801 Fig. Ia Gram-stained preparation to show C. minutissimum (x 250). copyright. http://jcp.bmj.com/ Fig. lb Gram-stained preparation to show C. minutissimum (x 480). on October 6, 2021 by guest. Protected J Clin Pathol: first published as 10.1136/jcp.25.9.799 on 1 September 1972. Downloaded from 802 R. Marks, N. D. Ramnarain, B. Bhogal, and N. T. Moore any morphological or histochemical changes caused by therapeutic measures. In this study of erythrasma, several features have come to light that are worthy of comment. There was a remarkable disparity between the numbers of bacteria seen in stained preparations with the light microscope and the numbers seen by SEM. This is probably a reflection of the fact that the 'surface' scanned by SEM using the skin surface biopsy method is five or six cell layers down into the .::. a .. .gk. stratum corneum, while with the light microscope the whole thickness of the specimen removed is exa- mined. Montes, Black, and McBride (1967) demon- strated by conventional EM that the great majority of the microorganisms of erythrasma did not invade further than the superficial part of the stratum corneum. This must also be a major contributing reason for the relatively small number of micro- organisms seen by SEM in this study. Fig. 2 Photomicrograph from skin surface biopsy tested The surfaces of the horn cells into which the with NA D diaphorase reaction. Note focal aggregation microorganisms had penetrated possessed a dis- offormazan reaction product ( x 250).
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