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Geoffrey Wilkinson
THE LONG SEARCH FOR STABLE TRANSITION METAL ALKYLS Nobel Lecture, December 11, 1973 by G EOFFREY W ILKINSON Imperial College of Science & Technology, London, England Chemical compounds in which there is a single bond between a saturated car- bon atom and a transition metal atom are of unusual importance. Quite aside from the significance and role in Nature of the cobalt to carbon bonds in the vitamin B 12 system and possible metal to carbon bonds in other biological systems, we need only consider that during the time taken to deliver this lec- ture, many thousands, if not tens of thousands of tons of chemical compounds are being transformed or synthesised industrially in processes which at some stage involve a transition metal to carbon bond. The nonchemist will pro- bably be most familiar with polyethylene or polypropylene in the form of do- mestic utensils, packaging materials, children’s toys and so on. These materials are made by Ziegler-Natta* or Philipps’ catalysis using titanium and chro- mium respectively. However, transition metal compounds are used as catalysts in the synthesis of synthetic rubbers and other polymers, and of a variety of simple compounds used as industrial solvents or intermediates. For example alcohols are made from olefins, carbon monoxide and hydrogen by use of cobalt or rhodium catalysts, acetic acid is made by carbonylation of methanol using rhodium catalysts and acrylonitrile is dimerised to adiponitrile (for nylon) by nickel catalysts. We should also not forget that the huge quantities of petroleum hydrocarbons processed by the oil and petrochemical industry are re-formed over platinum, platinum-rhenium or platinum-germanium sup- ported on alumina. -
Śląscy Nobliści: Otto Stern Kurt Alder Friedrich Bergius Śląscy Nobliści: Otto Stern, Kurt Alder, Friedrich Bergius Otto Stern ● Ur
Śląscy nobliści: Otto Stern, Kurt Alder, Friedrich Bergius Śląscy nobliści: Otto Stern Kurt Alder Friedrich Bergius Śląscy nobliści: Otto Stern, Kurt Alder, Friedrich Bergius Otto Stern ● ur. 17 lutego 1888 r. w Żorach ● zm. 17 sierpnia 1969 r.w Berkeley w stanie Kalifornia ● niemiecki fizyk ● wnuk bogatego kupca żydowskiego, właściciela żorskiego młyna ● w 1982 r. przeniósł się z rodziną do Wrocławia ● w 1912 r. uzyskał tytuł doktora chemii fizycznej na Uniwersytecie Wrocławskim ● podążając za Albertem Einsteinem, udał się na Uniwersytet Karola w Pradze, a rok później na Politechnikę w Zurychu ● tytuł doktora chemii fizycznej na Uniwersytecie Wrocławskim w roku 1912 r. ● jego rozprawa doktorska dotyczyła ciśnienia osmotycznego dwutlenku węgla w stężonych roztworach. Miała charakter zarówno praktyczny, jak też i teoretyczny. ● sam siebie określił jako „teoretyka doświadczalnego” Śląscy nobliści: Otto Stern, Kurt Alder, Friedrich Bergius ● w czasie I wojny światowej służył w różnych jednostkach technicznych armii pruskiej ● po klęsce Cesarstwa Niemieckiego przeniósł się do Frankfurtu ● w 1921 r. otrzymał stanowisko profesora fizyki teoretycznej na Uniwersytecie w Rostocku ● w 1923 r. objął stanowisko dyrektora w nowo powstałym Instytucie Chemii Fizycznej na Uniwersytecie w Hamburgu ● w 1922 r.wraz z Walterem Gerlachem przeprowadził eksperyment zwany „doświadczeniem Sterna-Gerlacha”, dzięki któremu doświadczalnie udowodnili kwantowanie momentu pędu, przyczynił się do rozwoju młodej fizyki kwantowej ● w 1933 r., ze względu na częściowe korzenie żydowskie, wyemigrował do USA ● do 1945 r. był profesorem na Carnegie Institute of Technology w Pittsburgu. Tam przystąpił do budowy laboratorium molekularnego ● 1943 r. przyniósł Sternowi Nobla z fizyki W uznaniu jego wkładu w rozwój metody wiązki molekularnej i jego odkrycia momentu magnetycznego protonu. -
Chemists Suggest a New Way to Synthesize Steroid Analogs 15 November 2017
Chemists suggest a new way to synthesize steroid analogs 15 November 2017 tandem cascade of reactions—the reactions proceed successively in the same flask under the same reaction conditions: acylation of the nitrogen atom of the starting 3-thienylallylamine with maleic anhydride, the intramolecular Diels-Alder reaction and subsequent aromatization of the cycloaddition adduct," says Fedor Zubkov, assistant professor of the Department of Organic Chemistry at the RUDN University. Diene synthesis (or the Diels-Alder reaction) is one of the most popular reactions in organic chemistry. It involves synchronous formation of two sigma- double bonds from one double bond of dienophile Intramolecular Diels-Alder reaction discussed in the and two double bonds of diene; the main product is research. Credit: Fedor Zubkov a six-membered ring with one double bond. Otto Diels and Kurt Alder received the Nobel Prize in 1950 for this reaction. Another Nobel laureate, Robert Woodward, was inspired and bound his life Scientists from RUDN University and the Ivan with chemistry after reading about Diels-Alder's Franko National University of Lviv have found a reaction. Later, he returned to it in his studies way to produce aromatic rings in organic several times. Curiously enough, it was Robert compounds in three stages. These stages proceed Woodward who founded the Tetrahedron Letters successively in one-pot conditions and at room journal, which published this paper by Russian temperature. Now analogues of hormones, scientists. steroids, some sugars, terpenes and other complex organic substances can be synthesized The intramolecular Diels-Alder reaction runs inside faster and at softer conditions. The paper was one molecule. -
Synthesis of Substituted Ring- Fused 2-Pyridones and Applications in Chemical Biology
Synthesis of Substituted Ring- Fused 2-Pyridones and Applications in Chemical Biology Christoffer Bengtsson Doctoral thesis Department of Chemistry Umeå University Umeå, Sweden 2013 Copyright © Christoffer Bengtsson 2013 ISBN: 978-91-7459-552-9 Electronic version available at http://umu.diva-portal.org/ Printed by: VMC-KBC, Umeå University Umeå, Sweden 2013 Author Christoffer Bengtsson Title Synthesis of Substituted Ring-Fused 2-Pyridones and Applications in Chemical Biology Abstract Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. According to the world health organization (WHO) there are about 440 000 new cases of multidrug-resistant tuberculosis emerging annually, causing at least 150 000 deaths. Consequently there is an immense need to develop new types of compounds with new modes of action for the treatment of bacterial infections. Presented herein is a class of antibacterial ring-fused 2- pyridones, which exhibit inhibitory effects against both the pili assembly system in uropathogenic Escherichia coli (UPEC), named the chaperone usher pathway, as well as polymerization of the major curli subunit protein CsgA, into a functional amyloid fibre. A pilus is an organelle that is vital for the bacteria to adhere to and infect host cells, as well as establish biofilms. Inhibition of the chaperone usher pathway disables the pili assembly machinery, and consequently renders the bacteria avirulent. The focus of this work has been to develop synthetic strategies to more efficiently alter the substitution pattern of the aforementioned ring- fused 2-pyridones. -
Robert Burns Woodward
The Life and Achievements of Robert Burns Woodward Long Literature Seminar July 13, 2009 Erika A. Crane “The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.” “Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect,” in Pointers and Pathways in Research (Bombay:CIBA of India, 1963). Robert Burns Woodward • Graduated from MIT with his Ph.D. in chemistry at the age of 20 Woodward taught by example and captivated • A tenured professor at Harvard by the age of 29 the young... “Woodward largely taught principles and values. He showed us by • Published 196 papers before his death at age example and precept that if anything is worth 62 doing, it should be done intelligently, intensely • Received 24 honorary degrees and passionately.” • Received 26 medals & awards including the -Daniel Kemp National Medal of Science in 1964, the Nobel Prize in 1965, and he was one of the first recipients of the Arthur C. -
Los Premios Nobel De Química
Los premios Nobel de Química MATERIAL RECOPILADO POR: DULCE MARÍA DE ANDRÉS CABRERIZO Los premios Nobel de Química El campo de la Química que más premios ha recibido es el de la Quí- mica Orgánica. Frederick Sanger es el único laurea- do que ganó el premio en dos oca- siones, en 1958 y 1980. Otros dos también ganaron premios Nobel en otros campos: Marie Curie (física en El Premio Nobel de Química es entregado anual- 1903, química en 1911) y Linus Carl mente por la Academia Sueca a científicos que so- bresalen por sus contribuciones en el campo de la Pauling (química en 1954, paz en Física. 1962). Seis mujeres han ganado el Es uno de los cinco premios Nobel establecidos en premio: Marie Curie, Irène Joliot- el testamento de Alfred Nobel, en 1895, y que son dados a todos aquellos individuos que realizan Curie (1935), Dorothy Crowfoot Ho- contribuciones notables en la Química, la Física, la dgkin (1964), Ada Yonath (2009) y Literatura, la Paz y la Fisiología o Medicina. Emmanuelle Charpentier y Jennifer Según el testamento de Nobel, este reconocimien- to es administrado directamente por la Fundación Doudna (2020) Nobel y concedido por un comité conformado por Ha habido ocho años en los que no cinco miembros que son elegidos por la Real Aca- demia Sueca de las Ciencias. se entregó el premio Nobel de Quí- El primer Premio Nobel de Química fue otorgado mica, en algunas ocasiones por de- en 1901 al holandés Jacobus Henricus van't Hoff. clararse desierto y en otras por la Cada destinatario recibe una medalla, un diploma y situación de guerra mundial y el exi- un premio económico que ha variado a lo largo de los años. -
A Nobel Synthesis
MILESTONES IN CHEMISTRY Ian Grayson A nobel synthesis IAN GRAYSON Evonik Degussa GmbH, Rodenbacher Chaussee 4, Hanau-Wolfgang, 63457, Germany he first Nobel Prize for chemistry was because it is a scientific challenge, as he awarded in 1901 (to Jacobus van’t Hoff). described in his Nobel lecture: “The synthesis T Up to 2010, the chemistry prize has been of brazilin would have no industrial value; awarded 102 times, to 160 laureates, of whom its biological importance is problematical, only four have been women (1). The most but it is worth while to attempt it for the prominent area for awarding the Nobel Prize sufficient reason that we have no idea how for chemistry has been in organic chemistry, in to accomplish the task” (4). which the Nobel committee includes natural Continuing the list of Nobel Laureates in products, synthesis, catalysis, and polymers. organic synthesis we arrive next at R. B. This amounts to 24 of the prizes. Reading the Woodward. Considered by many the greatest achievements of the earlier organic chemists organic chemist of the 20th century, he who were recipients of the prize, we see that devised syntheses of numerous natural they were drawn to synthesis by the structural Alfred Nobel, 1833-1896 products, including lysergic acid, quinine, analysis and characterisation of natural cortisone and strychnine (Figure 1). 6 compounds. In order to prove the structure conclusively, some In collaboration with Albert Eschenmoser, he achieved the synthesis, even if only a partial synthesis, had to be attempted. It is synthesis of vitamin B12, a mammoth task involving nearly 100 impressive to read of some of the structures which were deduced students and post-docs over many years. -
Cv Mlhg 2015
CURRICULUM VITAE Name: GREEN, Malcolm Leslie Hodder Address: St Catherine's College, Oxford or Inorganic Chemistry Laboratory South Parks Road OXFORD, OX1 3QR Date of Birth: 16/4/36, Eastleigh, Hampshire Nationality: British Marital Status: Married. Three children Degrees: B.Sc.(Hons), London; D.I.C., M.A.(Cantab), M.A.(Oxon), C.Chem., F.R.S.C., Ph.D., F.R.S. ACADEMIC CAREER 1953-56 Acton Technical College, University of London, B.Sc Hons. Chemistry 1956-59 Imperial College of Science and Technology, London; D.I.C. Ph.D. in chemistry. Supervisor Professor Sir G. Wilkinson 1959-60 Post-doctoral Research Associates Fellow. Imperial College of Science and Technology 1960-63 Assistant Lecturer in Inorganic Chemistry at Cambridge University 1961 Fellow of Corpus Christi College, Cambridge 1963 Sepcentenary Fellow of Inorganic Chemistry, Balliol College, Oxford and Departmental Demonstrator, University of Oxford 1965 University Lecturer, University of Oxford 1971 Visiting Professor, University of Western Ontario (Spring Term) 1972 Visiting Professor, Ecole de Chimie and Institute des Substances Naturelles, Paris (six months) 1973 A.P. Sloan Visiting Professor, Harvard University, (Spring Semester) 1979-84 Appointed to the British Gas Royal Society Senior Research Fellowship 1981 Sherman Fairchild Visiting Scholar at the California Institute of Technology(4 months) 1984 Re-appointed British Gas Royal Society Senior Research Fellow (1984-6) 1987 Vice-master, Balliol College, Oxford (T.T.) 1989 Appointed Professor of Inorganic Chemistry and Head of Department, Oxford University Fellow of St Catherine's College, Oxford 2004- present Emeritus Research Professor in the Inorganic Chemistry Laboratory, Oxford University Emeritus Fellow of Balliol College and St Catherine’s College Publications Two text books, 646 refereed papers and 8 patents. -
Guidelines and Suggested Title List for Undergraduate Chemistry Libraries, Serial Publication Number 44
DOCUMENT RESUME ED 040 037 SE 008 009 AUTHOR Marquardt, D. N., Ed. TITLE Guidelines and Suggested Title List for Undergraduate Chemistry Libraries, Serial Publication Number 44. INSTITUTION Advisory Council on Coll, Chemistry. PUB DATE Sep 69 NOTE 44p. AVAILABLE FROM Advisory Council on College Chemistry, Dept. of Chemistry, Stanford Univ., Stanford,California 94305 (free) EDRS PRICE EDRS P-: ice MF.40.25 HC-$2.30 DESCRIPTORS Advisory Committees, *Bibliographies,Booklists, *Chemistry, *College Science, *LibraryGuides, Research Reviews (Publications): *Resource Materials, Scholarly Journals IDENTIFIERS Advisory Council on College Chemistry ABSTRACT Contained are guidelines and an extensivelist of books and journals suitable for anundergraduate chemistry library. The guidelines are concerned with theorganization and acquisition policy of chemistry libraries, and withinter-library loan and photoduplication services. Various sections of the reportdeal with journals and abstracts, review serials,foreign language titles, U.S. Government publications and a suggestedtitles list. The books in the titles list are in the areas of analytical,biological, inorganic, organic and physical chemistry. Ingeneral, introductory texts have not been included. The list isarranged alphabetically with entries by author or editor unless the workis better known by title. The library of Congress classification numberand the Dewey Decimal classification number, when available, aregiven for each entry. Book prices are also given. The reportconcludes with a directory of publishers and dealers. This report shouldbe most useful for college libraries, science teachers, and students. (LC) 0 GUIDELINES AND SUGGESTEDTITLE LIST for t...UNDERGRADUATE CHEMISTRY LIBRARIES M CI Revised 1969 Co Co A Report Authorized by the ADVISORY COUNCIL ON COLLEGE CHEMISTRY Edited by D. -
Max Planck Institute for the History of Science Werner Heisenberg And
MAX-PLANCK-INSTITUT FÜR WISSENSCHAFTSGESCHICHTE Max Planck Institute for the History of Science PREPRINT 203 (2002) Horst Kant Werner Heisenberg and the German Uranium Project Otto Hahn and the Declarations of Mainau and Göttingen Werner Heisenberg and the German Uranium Project* Horst Kant Werner Heisenberg’s (1901-1976) involvement in the German Uranium Project is the most con- troversial aspect of his life. The controversial discussions on it go from whether Germany at all wanted to built an atomic weapon or only an energy supplying machine (the last only for civil purposes or also for military use for instance in submarines), whether the scientists wanted to support or to thwart such efforts, whether Heisenberg and the others did really understand the mechanisms of an atomic bomb or not, and so on. Examples for both extreme positions in this controversy represent the books by Thomas Powers Heisenberg’s War. The Secret History of the German Bomb,1 who builds up him to a resistance fighter, and by Paul L. Rose Heisenberg and the Nazi Atomic Bomb Project – A Study in German Culture,2 who characterizes him as a liar, fool and with respect to the bomb as a poor scientist; both books were published in the 1990s. In the first part of my paper I will sum up the main facts, known on the German Uranium Project, and in the second part I will discuss some aspects of the role of Heisenberg and other German scientists, involved in this project. Although there is already written a lot on the German Uranium Project – and the best overview up to now supplies Mark Walker with his book German National Socialism and the quest for nuclear power, which was published in * Paper presented on a conference in Moscow (November 13/14, 2001) at the Institute for the History of Science and Technology [àÌÒÚËÚÛÚ ËÒÚÓËË ÂÒÚÂÒÚ‚ÓÁ̇ÌËfl Ë ÚÂıÌËÍË ËÏ. -
Robert Burns Woodward 1917–1979
NATIONAL ACADEMY OF SCIENCES ROBERT BURNS WOODWARD 1917–1979 A Biographical Memoir by ELKAN BLOUT Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoirs, VOLUME 80 PUBLISHED 2001 BY THE NATIONAL ACADEMY PRESS WASHINGTON, D.C. ROBERT BURNS WOODWARD April 10, 1917–July 8, 1979 BY ELKAN BLOUT OBERT BURNS WOODWARD was the preeminent organic chemist Rof the twentieth century. This opinion is shared by his colleagues, students, and by other distinguished chemists. Bob Woodward was born in Boston, Massachusetts, and was an only child. His father died when Bob was less than two years old, and his mother had to work hard to support her son. His early education was in the Quincy, Massachusetts, public schools. During this period he was allowed to skip three years, thus enabling him to finish grammar and high schools in nine years. In 1933 at the age of 16, Bob Woodward enrolled in the Massachusetts Institute of Technology to study chemistry, although he also had interests at that time in mathematics, literature, and architecture. His unusual talents were soon apparent to the MIT faculty, and his needs for individual study and intensive effort were met and encouraged. Bob did not disappoint his MIT teachers. He received his B.S. degree in 1936 and completed his doctorate in the spring of 1937, at which time he was only 20 years of age. Immediately following his graduation Bob taught summer school at the University of Illinois, but then returned to Harvard’s Department of Chemistry to start a productive period with an assistantship under Professor E. -
Lecture 1: Strategies and Tactics in Organic Synthesis
Massachusetts Institute of Technology Organic Chemistry 5.511 October 3, 2007 Prof. Rick L. Danheiser Lecture 1: Strategies and Tactics in Organic Synthesis Retrosynthetic Analysis The key to the design of efficient syntheses ". the grand thing is to be able to reason backwards. That is a very useful accomplishment, and a very easy "The end is where we start from...." one, but people do not practice it much." T. S. Eliot, in "The Four Quartets" Sherlock Holmes, in "A Study in Scarlet" Strategy Tactics overall plan to achieve the means by which plan ultimate synthetic target is implemented intellectual experimental retrosynthetic planning synthetic execution TRANSFORMS REACTIONS Target Precursor Precursor Target Definitions Retron Structural unit that signals the application of a particular strategy algorithm during retrosynthetic analysis. Transform Imaginary retrosynthetic operation transforming a target molecule into a precursor molecule in a manner such that bond(s) can be reformed (or cleaved) by known or reasonable synthetic reactions. Strategy Algorithm Step-by-step instructions for performing a retrosynthetic operation. "...even in the earliest stages of the process of simplification of a synthetic problem, the chemist must make use of a particular form of analysis which depends on the interplay between structural features that exist in the target molecule and the types of reactions or synthetic operations available from organic chemistry for the modification or assemblage of structural units. The synthetic chemist has learned by experience to recognize within a target molecule certain units which can be synthesized, modified, or joined by known or conceivable synthetic operations...it is convenient to have a term for such units; the term "synthon" is suggested.