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Certificate of Fetal Brain Imaging Certificate of fetal brain imaging Suggested reading 1. Chaoui R, Nicolaides KH. Detecting open spina bifida at the 11-13-week scan by assessing intracranial translucency and the posterior brain region: mid-sagittal or axial plane? Ultrasound Obstet Gynecol. 2011 Dec;38(6):609-12. doi:10.1002/uog.10128. PubMed PMID: 22411445. 2. Lerman-Sagie T, Prayer D, Stöcklein S, Malinger G. Fetal cerebellar disorders. Handb Clin Neurol. 2018;155:3-23. doi:10.1016/B978-0-444-64189-2.00001-9. Review: PubMed PMID: 29891067. 3. Choudhri AF, Cohen HL, Siddiqui A, Pande V, Blitz AM. Twenty-Five Diagnoses on Midline Images of the Brain: From Fetus to Child to Adult. Radiographics. 2018 Jan- Feb;38(1):218-235. doi:10.1148/rg.2018170019. Review. PubMed PMID: 29320328. 4. Davila I, Moscardo I, Yepez M, Sanz Cortes M. Contemporary Modalities to Image the Fetal Brain. Clin Obstet Gynecol. 2017 Sep;60(3):656-667. doi:10.1097/GRF.0000000000000307. PubMed PMID: 28742597. 5. Jakab A, Pogledic I, Schwartz E, Gruber G, Mitter C, Brugger PC, Langs G, Schöpf V, Kasprian G, Prayer D. Fetal Cerebral Magnetic Resonance Imaging Beyond Morphology. Semin Ultrasound CT MR. 2015 Dec;36(6):465-75. doi:10.1053/j.sult.2015.06.003. Epub 2015 Jun 14. Review. PubMed PMID: 26614130. Ultrasound Obstet Gynecol 2007; 29: 109–116 Published online in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/uog.3909 GUIDELINES Sonographic examination of the fetal central nervous system: guidelines for performing the ‘basic examination’ and the ‘fetal neurosonogram’ INTRODUCTION Some abnormalities may be visible in the first and early second trimesters6–11. Even though these may represent Central nervous system (CNS) malformations are some of a minority they usually are severe and deserve therefore the most common of all congenital abnormalities. Neural special consideration. It is true that early examination tube defects are the most frequent CNS malformations and requires special skills, however, it is always worthwhile to amount to about 1–2 cases per 1000 births. The incidence pay attention to the fetal head and the brain at earlier ages. of intracranial abnormalities with an intact neural tube is The advantage of an early fetal neuroscan at 14–16 weeks uncertain as probably most of these escape detection at is that the bones are thin and the brain may be evaluated birth and only become manifest in later life. Long-term from almost all angles. follow-up studies suggest however that the incidence may Usually, a satisfying evaluation of the fetal CNS can be as high as one in 100 births1. always be obtained in the second and third trimesters Ultrasound has been used for nearly 30 years as the of pregnancy. In late gestation, visualization of the main modality to help diagnose fetal CNS anomalies. The intracranial structures is frequently hampered by the scope of these guidelines is to review the technical aspects ossification of the calvarium of an optimized approach to the evaluation of the fetal brain in surveys of fetal anatomy, that will be referred Technical factors to in this document as a basic examination. Detailed evaluation of the fetal CNS (fetal neurosonogram) is also Ultrasound transducers possible but requires specific expertise and sophisticated ultrasound machines. This type of examination, at High frequency ultrasound trandsucers increase spatial times complemented by three-dimensional ultrasound, resolution but decrease the penetration of the sound is indicated in pregnancies at increased risk of CNS beam. The choice of the optimal transducer and anomalies. operating frequency is influenced by a number of In recent years fetal magnetic resonance imaging (MRI) factors including maternal habitus, fetal position and the has emerged as a promising new technique that may add approach used. Most basic examinations are satisfactorily important information in selected cases and mainly after performed with 3–5-MHz transabdominal transducers. 20–22 weeks2,3, although its advantage over ultrasound Fetal neurosonography frequently requires transvaginal remains debated4,5. examinations that are usually conveniently performed with transducers between 5 and 10 MHz12,13 Three- dimensional ultrasound may facilitate the examination 14,15 GENERAL CONSIDERATIONS of the fetal brain and spine . Gestational age Imaging parameters The appearance of the brain and spine changes throughout The examination is mostly performed with gray-scale bidi- gestation. To avoid diagnostic errors, it is important mensional ultrasound. Harmonic imaging may enhance to be familiar with normal CNS appearances at visualization of subtle anatomic details, particularly in different gestational ages. Most efforts to diagnose patients who scan poorly. In neurosonographic studies, neural anomalies are focused around midgestation. Basic Color and power Doppler may be used, mainly to iden- examinations are usually performed around 20 weeks’ tify cerebral vessels. Proper adjustment of pulse repetition gestation. frequency (main cerebral arteries have velocities in the Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd. ISUOGGUIDELINES 110 Guidelines range of 20–40 cm/s during intrauterine life)16 and signal Table 1 Structures that are usually noted in a basic ultrasound persistence enhances visualization of small vessels. examination of the fetal central nervous system Head shape BASIC EXAMINATION Lateral ventricles Cavum septi pellucidi Qualitative evaluation Thalami Cerebellum Transabdominal sonography is the technique of choice Cisterna magna Spine to investigate the fetal CNS during late first, second and third trimesters of gestation in low risk pregnancies. The examination should include the evaluation of the fetal a well defined lateral wall and medially are separated by head and spine. the cavum septi pellucidi (CSP). The CSP is a fluid filled Two axial planes allow visualization of the cerebral cavity between two thin membranes. In late gestation structures relevant to assess the anatomic integrity of the or the early neonatal period these membranes usually brain17. These planes are commonly referred to as the fuse to become the septum pellucidum. The CSP becomes transventricular plane and the transcerebellar plane.A visible around 16 weeks and undergoes obliteration near third plane, the so-called transthalamic plane, is frequently term gestation. With transabdominal ultrasound, it should added, mostly for the purpose of biometry (Figure 1). always be visualized between 18 and 37 weeks, or with Structures that should be noted in the routine examination a biparietal diameter of 44–88 mm18. Conversely, failure include the lateral ventricles, the cerebellum and cisterna to demonstrate the CSP prior to 16 weeks or later than magna, and cavum septi pellucidi.Headshapeandbrain 37 weeks is a normal finding. The value of visualizing texture should also be noted on these views (Table 1). the CSP for identifying cerebral anomalies has been debated17. However, this structure is easy to identify The transventricular plane and is obviously altered with many cerebral lesions such as holoprosencephaly, agenesis of the corpus callosum, This plane demonstrates the anterior and posterior severe hydrocephaly and septo-optic dysplasia19. portion of the lateral ventricles. The anterior portion From about 16 weeks the posterior portion of the of the lateral ventricles (frontal or anterior horns) appears lateral ventricles (also referred to as posterior horns) as two comma-shaped fluid filled structures. They have is in reality a complex formed by the atrium that continues posteriorly into the occipital horn. The atrium is characterized by the presence of the glomus of the choroid plexus, which is brightly echogenic, while the occipital horn is fluid filled. Particularly in the second trimester of gestation both the medial and lateral walls of the ventricle are parallel to the midline and are therefore well depicted sonographically as bright lines. Under normal conditions the glomus of the choroid plexus almost completely fills the cavity of the ventricle at the level of the atrium being closely apposed to both the medial or lateral walls, but in some normal cases a small amount of fluid may be present between the medial wall and the choroid plexus20–23. In the standard transventricular plane only the hemisphere on the far side of the transducer is usually clearly visualized, as the hemisphere close to the transducer is frequently obscured by artifacts. However, most severe cerebral lesions are bilateral or associated with a significant deviation or distortion of the midline echo, and it has been suggested that in basic examinations symmetry of the brain is assumed17. The transcerebellar plane This plane is obtained at a slightly lower level than that of the transventricular plane and with a slight posterior tilting and includes visualization of the frontal horns of the lateral ventricles, CSP, thalami, cerebellum and cisterna Figure 1 Axial views of the fetal head. (a) Transventricular plane; magna. The cerebellum appears as a butterfly shaped (b) transthalamic plane; (c) transcerebellar plane. structure formed by the round cerebellar hemispheres Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd. Ultrasound Obstet Gynecol 2007; 29: 109–116. Sonographic examination of the fetal central nervous system 111 joined in the middle by the slightly more echogenic includes the measurement of the biparietal diameter, head cerebellar vermis. The cisterna magna or cisterna circumference and internal diameter of the atrium.
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