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Anatomical Variations of Septum Pellucidum

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Anatomical Variations of Septum Pellucidum Update in Radiology Anatomical variations of septum pellucidum P. Sartori*, V. Anaya, Y. Montenegro, M. Cayo and G. Barba Computed Tomography and Magnetic Resonance Imaging Department, EDES, Hospital Español, Ciudad Autónoma de Buenos Aires, Argentina Abstract Septum Pellucidum is a thin medial septum of triangular shape that consists of two nervous laminae that are attached and located between the corpus callosum and the fornix. Anatomical variations of septum pellucidum appear during fetal life in the ventro-dorsal position. These variations are: cavum septi pellucidi, cavum vergae and cavum veli interpositi. The presence or absence of these cavities can be related to the presence of nervous system or neuropsychiatric dysfunction, therefore they should be well known to avoid wrong diagnoses © 2014 Sociedad Argentina de Radiología. Published by Elsevier Spain, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Keywords: Septum pellucidum; Cavum septum pellucidum; Cavum vergae; Cavum vellum interpositum Introduction interpositi (CVI). They occur with a prevalence of 0.14%8-10. It is important to highlight that these cavities are in direct con- During intrauterine life, there are normal midline cavities tact with the subarachnoid space, but they do not communi- which usually persist in adulthood and should not be con- cate with or are considered part of the ventricular system. As fused with pathological entities. It is important to know these cavities are not lined with ependyma or choroid plexus 3,9-11 them, as they may may be related to concomitant neurologi- cells, they do not produce cerebrospinal fluid (CSF) . cal or neuropsychological diseases. In this article, we review 1) Cavum septum pellucidum: it is also known as cavum septi the septum pellucidum (SP) and its anatomical variations. pellucidi, the ventricle of the septum or fifth ventricle (fig. 3,8,10,12 In Latin, the word septum (saepire) means fence or partition 2) . It can be found in all fetuses at 36 weeks’ ges- wall, while pellucidum or perlucidum means translucent. Thus, tation and persists in 36% of full-term infants, only 6% of 3,4,11-13 SP (or lucidum) is a thin medial septum of triangular shape that them persist after the six month of live . It is signifi- 3 consists of two nervous laminae that are attached and located cantly more common in women . between the corpus callosum and the fornix (fig. 1)1-5. In 1966, CSP is part of normal development. As from 12 weeks of Andy and Stephen called it “telencephalic septum” (septum gestational age, the corpus callosum starts to develop from telencephali) 6. Boundaries are described in table 11,4-6. the lamina terminalis as a fiber bundle that connects the two The SP serves as a relay station, containing fibers that con- hemispheres, also originating the SP. The space between the nect with hippocampus and the hypothalamus2. Complete two laminae that are not fused, located between the frontal absence of the SP occurs in 2 to 3 individuals per 100 000 horns of the lateral ventricles and anterior to the foramen of 10,11,14 people, being a predictor of brain abnormalities, such as: Monro is called CSP (fig. 3) . septooptic dysplasia, corpus callosum abnormalities, holo- A number of theories have been proposed for the origin of prosencephaly, lissencephaly or Chiari malformation6,7. CSP, but it is thought that during embryo-fetal development, During intrauterine life, there are three potential cavities in the mass of cells occupying the space of the SP is involved in the midline between the lateral ventricles. These cavities re- the development of the commissural plate. Selective elimi- gress between the seventh month of fetal life and the second nation of this group of cells would lead (by necrosis) to the year of postnatal life, but some may persist in adulthood8,9. molecular concentration of large amounts of amino acids, These cavities, first described in the year 1600, include: cavum which would attract fluids to achieve a balance in the oncotic septum pellucidum (CSP), cavum vergae (CV) and cavum veli pressure of the plate. Fluid pressure would be responsible for 80 Rev. Argent. Radiol. 2015;79(2): 80-85 P. Sartori et al. the formation of CSP12. However, it has also been hypoth- There are US studies in which CSP has been identified in esized that this entity may originate during infancy, as a result 100% of fetuses between 18 and 37 weeks’ gestation, and of repeated shaking, when rocking infants vigorously in an in 79% of fetuses between 30 and 41 weeks’ gestation; in attempt to soothe them12. newborns, complete posterior closure has been seen in 97%, CSP is a triangular space between the two laminae of the so the CSP is present when the cavum vergae is absent16. septum pellucidum (its boundaries are detailed in table Hence, visualization of the CSP between 18 and 20 weeks’ 2)3,4,8,10,12,13,15,16. CSP may occur in isolation or in asso- gestation implies normal development of the brain16. ciation with cavum vergae, communicating with the latter In patients with schizophrenia or in aggressive, alcoholic in- through the aqueductus caudae septi or aqueductus ven- dividuals or people with neurological development disorders, triculii vergae7,8. there is a higher prevalence of enlarged CSP3-5,11,14,15,17,18. CSP is an important marker for the evaluation of normal de- It was De Greef who first reported an association between velopment of the fetal neural axis. Absence of the CSP is rare- CSP and schizophrenia11. ly an isolated finding, as nonvisualization of the CSP on ul- Some authors report an association between boxing and the trasound (US) or magnetic resonance imaging (MRI) scans in presence of CSP due to repeated brain trauma. An associa- fetal life is associated with brain malformations, such as holo- tion between CSP and posttraumatic stress disorders has also prosencephaly, septo-optic dysplasia, agenesis of the corpus been reported, in the military population currently participat- callosum, Alexander disease, tuberous sclerosis, phakomato- ing in war conflicts or in veterans of wars2,3,5,12,13,15,17. sis, pinealoma, trisomy 21 and schizencephaly3,10,12,14,16. There are various classifications for CSP. Based on whether Considering embryonic development, CSP may not occur the CSP communicates with the lateral ventricles through without the development of the corpus callosum; therefore fenestrations, it may be classified as communicating or non- agenesis of the corpus callosum is always associated with communicating (more common)2,13. However, another clas- agenesis of the SP3,4. sification focuses on asymptomatic (communicating or non- Table 1: Boundaries of the septum pellucidum. Boundary Structure SUPERIOR Inferior surface of the body of corpus callosum ANTEROINFERIOR Superior surface of the genu of corpus callosum POSTEROINFERIOR Corpus and columns of the fornix LATERAL Medial wall of frontal horns of lateral ventricles MEDIAL Virtual space with contralateral septum Figure 1 Axial T2-weighted magnetic resonance imaging of Figure 2 Sketch of axial and sagittal views of the cavum sep- the brain demonstrating normal appearance of the septum tum pellucidum. pellucidum (lucidum) (arrow). Rev. Argent. Radiol. 2015;79(2): 80-85 81 Anatomical variations of septum pellucidum communicating CSP) and symptomatic (non-communicating 3) Cavum velum interpositum (CVI) was first described by CSP) characteristics; the latter may be simple, not complicat- Kruse and Schaetz in 19309,10. It is also known as cisterna ed or complicated by brain injuries12. interventricularis, ventriculi tertii, transverse fissure or sub- 2) Cavum vergae: Andrea Verga, an italian anatomist de- trigonal fissure9. The incidence of CVI ranges, according to scribed it in 1851. Iit is also known as cavum fornicis, cavum various authors, between 21 and 34%, and persistence in psalterii, Verga´s ventricle, the ventricle of Strambio, ven- postnatal life is rare, being 30% in 1-10 year-old children, triculus triangularis or sixth ventricle10,12,13. Cavum vergae is with no significant differences between genders9. the posterior extension of CSP, extending as far as the pos- CVI is a subarachnoid cistern arising as an extension of the terior columns of the fornix and the foramen of Monro (fig. cisterna magna and which originates from the roof plate of 4)9,10,13. It is triangular in shape (its boundaries are listed in the diencephalo, protruding into the primitive neural tube table 3)4,5,10,13. approximately during the third fetal month. CVI is a normal Cavum vergae begins to develop by the 5th month of gesta- tion and disappears by two months of age 10. CV is present in 30% of normal newborns, subsequently regressing and Table 2: Boundaries of the cavum septum pellucidum. disappearing13. The incidence of CV was 2.3% in 1032 brains studied, and it Boundary Structure is important to highlight that it is almost always found in as- sociation with CSP7,9,10,13 When the CSP is dilated, the CV is ANTERIOR Genu of corpus callosum also dilated, as they join through a defect of the fornix, which POSTERIOR Corpus and columns of the fornix is not in contact with the corpus callosum10 (fig. 5). Some authors report a higher prevalence of enlarged CSP or SUPERIOR Inferior border of the body of CV in patients with schizophrenia10. corpus callosum INFERIOR Rostrum of the corpus callosum and anterior white commissure LATERAL Laminae of septum pellucidum Table 3: Boundaries of the cavum vergae.. Boundary Structure ANTERIOR Crus of the fornix POSTERIOR Body of the corpus callosum SUPERIOR Splenium of the corpus callosum INFERIOR Hippocampal commissure and psalterium (lyra davidis) Figure 3 Axial T1-weighted magnetic resonance of the brain Figure 4 Sketch of axial and sagittal views of the cavum sep- demonstrating the presence of a triangular cavity between tum pellucidum associated with the cavum vergae.
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