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Xerox University Microfilms 300 North Zeeb Road Ann Arbor, Michigan 48106 73-20,651 TIME OF ORIGIN OF BASAL FOREBRAIN NEURONS IN THE MOUSE: AN AUTORADIOGRAPHIC STUDY Item Type text; Dissertation-Reproduction (electronic) Authors Creps, Elaine Sue, 1946- Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 07/10/2021 05:12:20 Link to Item http://hdl.handle.net/10150/290321 INFORMATION TO USERS This material was produced from a microfilm copy of the original document. While the most advanced technological means to photograph and reproduce this document have been used, the quality is heavily dependent upon the quality of the original submitted. The following explanation of techniques is provided to help you understand markings or patterns which may appear on this reproduction. 1. The sign or "target" for pages apparently lacking from the document photographed is "Missing Paga(s)". If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting thru an image and duplicating adjacent pages to insure you complete continuity. 2. When an image on the film is obliterated with a large round black mark, it is an indication that the photographer suspected that the copy may have moved during exposure and thus cause a blurred image. You will find a good image of the page in the adjacent frame. 3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material. It is customary to begin photoing at the upper left hand corner of a large sheet and to continue photoing from left to right in equal sections with a small overlap. If necessary, sectioning is continued again — beginning below the first row and continuing on until complete. 4. The majority of users indicate that the textual content is of greatest value, however, a somewhat higher quality reproduction could be made from "photographs" if essential to the understanding of the dissertation. Silver prints of "photographs" may be ordered at additional charge by writing the Order Department, giving the catalog number, title, author and specific pages you wish reproduced. 5. PLEASE NOTE: Some pages may have indistinct print. Filmed as received. Xerox University Microfilms 300 North Zeeb Road Ann Arbor, Michigan 48106 73-20,651 CREPS, Elaine Sue Edmonds, 1946- TIME OF ORIGIN OF BASAL FOREBRAIN NEURONS IN THE MOUSE: AN AUTORADIOGRAPHIC STUDY. The University of Arizona, Ph.D., 1973 Anatomy University Microfilms, A XEROX Company , Ann Arbor, Michigan THIS DISSERTATION HAS BEEN MICROFLIMED EXACTLY AS RECEIVED TIME OF ORIGIN OF BASAL FOREBRAIN NEURONS IN THE MOUSE: AN AUTORADIOGRAPHIC STUDY by Elaine Sue Creps A Dissertation Submitted to the Faculty of the DEPARTMENT OF ANATOMY In Partial Fulfillment of the Requirements For the Degree of DOCTOR OF PHILOSOPHY In the Graduate College THE UNIVERSITY OF ARIZONA 19 7 3 THE UNIVERSITY OF ARIZONA GRADUATE COLLEGE I hereby recommend that this dissertation prepared under my direction by Elaine Sue C'reps entitled Time of Origin of Basal Forebrain Neurons in the Mouse: An Autoradiographic Study be accepted as fulfilling the dissertation requirement of the degree of Doctor of Philosophy , 7yUweA. , 1 cl 7 3 Dissertation Director Date After inspection of the final copy of the dissertation, the follov/ing members of the Final Examination Committee concur in its approval and recommend its acceptance:- /'• Ztv '#/ j& •• j- / y f /97J fV.Z&aJt, "Tfadil /9?3 ^Uu-,/<a ci /4 73. 2. "y, This approval and acceptance is contingent on the candidate's adequate performance and defense of this dissertation at the final oral examination. The inclusion of this sheet bound into the library copy of the dissertation is evidence of satisfactory performance at the final examination. STATEMENT BY AUTHOR This dissertation has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the Library. Brief quotations from this dissertation are allowable without special permission, provided that accurate acknowledgment of source is made. Requests for permission for extended quotation from or reproduc­ tion of this manuscript in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his judgment the proposed use of the material is in the interests of schol­ arship. In all other instances, however, permission must be obtained from the author. SIGNED: s&tfrur ACKNOWLEDGMENTS This dissertation was made possible by its director, Dr. Jay B. Angevine, Jr., to whom I will always be grateful. His support and interest, as well as his constant attention to the details of this manuscript, have turned an idea into a finished product. I would also like to express my appreciation to all members of the Department of Anatomy who have given me assistance throughout my graduate training. I am especially grateful to Dr. John W. Sechrist for his patience, and many helpful suggestions during preparation of this paper. Thanks also are extended to Dr. Elizabeth Taber Pierce, who generously loaned part of her slide collection for this study. I am indebted to Miss Almera Seber for her technical assistance and Michael Barnard for her technical advice. Special thanks also go to Mrs. Barbara Spalding for her careful typing of this manuscript. iii TABLE OF CONTENTS Page LIST OF ILLUSTRATIONS vii LIST OF TABLES xi ABSTRACT xii 1. INTRODUCTION 1 2. HISTORICAL PERSPECTIVE 5 Proliferation in the Neural Tube ...... 5 Classicial Studies 5 Autoradiographic Studies 9 Recent Golgi and Electron Microscopic Studies 14 Differentiation of Neurons 17 Classical Studies 17 Electron Microscopic Studies 19 Recent Golgi Studies 22 3. AUTORADIOGRAPHIC STUDIES OF REGIONAL HISTOGENESIS 25 Spinal Cord 25 Myelencephalon 25 Metencephalon 28 Pons 28 Cerebellum 29 Mesencephalon 36 Diencephalon 37 Telencephalon 1+1 Olfactory Centers 4l Hippocampal Region 42 Cerebral Cortex 45 Other Telencephalic Centers 46 4. THE BASAL FOHEBRAIN 48 Olfactory Tracts and Anterior Commissure 49 Medial Forebrain Bundle 51 Fornix 52 iv V TABLE OF CONTENTS--Continued Page Stria Terminalis 53 Diagonal Band of Broca 53 Stria Medullaris Thalami . 5^- 5. AUTORADIOGRAPHY 56 History 56 The Radioisotope 59 The Autoradiographic Process 60 6. MATERIALS AMD METHODS 62 Animals 62 Injection of Tritiated Thymidine 61+ Fixation . 65 Embedding and Sectioning 66 Staining for Myelin 67 Autoradiography - Dipping ..... 67 Autoradiography - Development . 68 Nuclear Staining 69 Analysis of Autoradiograms 69 7. RESULTS 72 Basal Olfactory Region 73 Anterior Olfactory Nucleus 73 Nucleus of the Lateral Olfactory Tract 75 Olfactory Tubercle 75 Basal Islands 76 Preoptic Area 78 Periventricular Region 79 Medial Preoptic Nucleus . 80 Lateral Preoptic Region 8l Magnocellular Preoptic Nucleus . 82 Septal Area 82 Medial Septal Nucleus 84- Triangular Septal Nucleus «... 8U Fimbrial Septal Nucleus 85 Lateral Septal Nucleus 00... 85 Nucleus Accumbens Septi 86 Nucleus of the Diagonal Band of Broca 87 Interstitial Nucleus of the Stria Terminalis 88 Nucleus of the Anterior Commissure 89 Summary of Observations 89 vi TABLE OF CONTENTS--Continued Page 8. DISCUSSION 92 Significance of Results 92 Comparison of Results with Other Studies 92 Postnatal Neurogenesis 97 Gradients 100 Time of Origin Related to Other Events in Neurogenesis . 105 Nucleus Accurabens - Septal or Striatal? 109 Phylogenetic Parallels of Time of Origin 110 The Question of the Telodiencephalic Boundary 112 APPENDIX: AUTORADIOGRAPHIC RECONSTRUCTIONS AND GRAPHS .... 117 LITERATURE CITED 175 LIST OF ILLUSTRATIONS Figure Page 1. Basal and sagittal views of the mouse brain illustrating levels I-V used to prepare autoradiographic reconstructions 119 2. Pattern of labelling in anterior olfactory nucleus on Ell and early on E12 120 3. Pattern of labelling in anterior olfactory nucleus late on E12 and on E13 121 Pattern of labelling in anterior olfactory nucleus early on El^+ and late on El^- 122 5- Pattern of labelling in anterior olfactory nucleus on E15 and early on El6 123 6. Pattern of labelling in anterior olfactory nucleus on E17 and early on El8 12^4- 7. Pattern of labelling in anterior olfactory nucleus late on El8 and on postnatal day one . 125 8. Pattern of labelling at rostral septal level on -ElO 126 9. Pattern of labelling at rostral septal level on Ell 127 10. Pattern of labelling at rostral septal level early on E12 128 11. Pattern of labelling at rostral septal level late on E12 129 12. Pattern of labelling at rostral septal level on E13 ^3° 13'. Pattern of labelling at rostral septal level early on El4 131 lb. Pattern of labelling at rostral septal level late on El^ 132 15• Pattern of labelling at rostral septal level on E15 ^-33 vii viii LIST OF ILLUSTRATIONS--Continued Figure Page 16. Pattern of labelling at rostral septal level early on El6 13^ 17. Pattern of labelling at rostral septal level late on El6 135 18. Pattern of labelling at rostral septal level on E17 136 19. Pattern of labelling at rostral septal level early on El8 137 20. Pattern of labelling at rostral septal level late on El8 138 21. Pattern of labelling at rostral septal level on postnatal day one 139 22. Pattern of labelling at rostral septal level on postnatal day four lUo 23. Pattern of labelling at middle septal and rostral preoptic level on E10 lUl 2b. Pattern of labelling at middle septal and rostral preoptic level on Ell 1^2 25. Pattern of labelling at middle septal and rostral preoptic level early on E12 1^3 26.
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