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Msc-Mb-Syll-201718.Pdf ----------------------------------------------------------------------------------------------- Department of Microbiology CURRICULUM AND SYLLABI FOR MSc MICROBIOLOGY PROGRAM The Department of Microbiology, Central University of Tamil Nadu offers a two-year full-time MSc Degree Program in Microbiology. Purpose: To impart knowledge and training across the different fields in Microbiology to be able to equip students for academics/industry. Eligibility: Bachelor’s degree in Microbiology, Applied Microbiology, Human Genetics, Nutrition and Dietetics, Botany, Zoology, Biochemistry, Biotechnology, Life Sciences, Dairy Sciences, Agriculture and Horticulture, Home Science, Veterinary Sciences, Fisheries Sciences, Public Health, and Allied Health Sciences from a recognized university or equivalent. Candidates should have secured a minimum of 60% marks or 6.5 CGPA (on a 10-point scale) in the qualifying degree examination for General Category, 55% marks or 6.0 CGPA (on a 10-point scale) for OBC (non-creamy layer) and 50% aggregate marks or 5.5 CGPA (on a 10-point scale) for SC/ST/PWD candidates. Credits: The program consists of courses with a total of 72 credits. Core Course (CC): 60 credits Elective Course (EC): 12 credits Number of Semesters, Course Distribution: The program comprises 4 semesters; each semester has courses equivalent of 20 credits. Project Work & Dissertation: Compulsory, with 6 credits in Semester IV to impart research training. MSc Microbiology: Semester 1 COURSE TYPE NUMBER OF SL. NO. COURSE NAME CODE OF COURSE CREDITS I Semester: Theory 1 General Microbiology CMB101 CC 3 2 Cell & Molecular Biology CMB102 CC 3 3 Microbial Biochemistry CMB103 CC 3 4 Immunobiology CMB104 CC 3 5 Microbial Genetics CMB105 CC 3 6 Microbial Physiology CMB106 CC 3 I Semester: Practicals 1 Practical Microbiology I PMB101 CC 2 2 Practical Microbiology II PMB102 CC 2 MSc Microbiology: Semester 2 COURSE TYPE NUMBER OF SL. NO. COURSE NAME CODE OF COURSE CREDITS II Semester: Theory 1 Bacteriology & Mycology CMB201 CC 3 2 Virology & Parasitology CMB202 CC 3 3 Food & Industrial Microbiology CMB203 CC 3 4 Agricultural Microbiology & Plant Pathology CMB204 CC 3 5 Methods in Gene Technology CM205 CC 3 6 Biosafety, Bioethics & IPR CMB206 CC 3 II Semester: Practicals 1 Practical Microbiology III PMB201 CC 2 2 Practical Microbiology IV PMB202 CC 2 MSc Microbiology: Semester 3 COURSE TYPE NUMBER OF SL. NO. COURSE NAME CODE OF COURSE CREDITS III Semester: Theory 1 Computational Biology & Biostatistics CMB301 CC 3 2 Marine Microbiology CMB302 CC 3 3 Environmental Microbiology CMB303 CC 3 4 Pharmaceutical Microbiology CMB304 CC 3 5 Medical Microbiology CMB305 CC 3 6 Microbial Technology CMB306 CC 3 III Semester: Practicals 1 Practical Microbiology V PMB301 CC 2 2 Practical Microbiology VI PMB302 CC 2 MSc Microbiology: Semester 4 COURSE TYPE NUMBER OF SL. NO. COURSE NAME CODE OF COURSE CREDITS IV Semester: Theory 1 Biomedical Techniques EMB401 EC 3 2 Diagnostic Microbiology EMB402 EC 3 3 Drug Design and Discovery EMB403 EC 3 4 Nanotechnology Applications in Microbiology EMB404 EC 3 COURSE TYPE NUMBER OF SL. NO. COURSE NAME CODE OF COURSE CREDITS IV Semester: Project Work 1 SEEC/Project/Dissertation CMB401 CC 6 Total Number of Credits 84 MSc Microbiology: Semester 1 GENERAL MICROBIOLOGY Course Code: CMB101 Total Number of Credits: 03 General Microbiology course is aimed at introducing the history and development of microbiology. The contents aims to help students understand the history, biology, and growth and control of microorganisms. Beginners of the course are rightly exposed to the foundation of microbiology, which would lead them towards progressive advancement of the subject. Unit 1: Scope of microbiology, Ancient microbiology - Refutation of a biogenesis: Discovery of penicillin: Discovery of vaccination: One-gene one-enzyme hypothesis, Contribution of scientists – Leeuwenhoeck, Edward Jenner, Alexander Fleming, Joseph Lister, Robert Koch, Louis Pasteur, Hargobind Khorrana. Modern Microbiology: Landmark achievements in 20th century. Microbial taxonomy - Definition and systematics, Nomenclatural rules and identification. Haeckel’s three kingdom classification, Whittaker’s five kingdom approach - Woese domain system. Major characteristics used in taxonomy: Morphological, physiological and metabolic, genetic and molecular taxonomy. Bergey’s Classification of bacteria. Unit 2: Differences between prokaryotic and eukaryotic cell. Biology of bacteria - cell structure, size, shape, arrangement membrane, cell wall, cytoplasmic inclusions, mesosomes, flagella and motility, slime, glycocalyx, capsule, pili, chemotaxis, endospore - biology of fungi, structure, physiology and classification – biology of yeast – reproduction - virus (bacteriophages) structure, life cycle (lytic and lysogenic) – biology of algae – mycoplasma – prions. Unit 3: Microbial nutrition: Microbial nutrient requirements, macro-nutrients, micro-elements, growth factors, sources of nutrients, nutritional classification of bacteria: phototroph, chemotroph, autotroph, heterotroph, photoautotroph, photoheterotroph, chemoautotroph, chemoheterotroph – nutritional patterns of pathogens – saprophytes – auxotroph. Unit 4: Extremophiles: Diversity of microorganisms of arctic, antarctic and hydrothermal vents – Archaeal biology - acidophile, alkaliphile, anaerobe, cryptoendolith, halophile, hyperthermophile, hypolith, lithoautotroph, metal-tolerant microbes, oligotroph, osmophile, piezophile, polyextremophile, psychrophile/cryophile, radio-resistant, thermophile, thermoacidophile, xerophile – mechanism of extremophiles. Unit 5: Cultivation and control of microbes: Types of growth media (natural, synthetic, complex, enriched, selective- definition with examples), pure culture methods (streak plate, spread plate, pour plate, stab culture, slant culture). Anaerobic (thioglycollate, anaerobic chamber, Robertson’s media, microaerophilic), liquid shake culture of aerobic bacteria, Control of microbes - sterilisation, disinfection, antiseptic, tyndalization, pasteurization: physical - dry heat, moist heat, UV light, ionizing radiation, filtration, HEPA filter, chemical methods. References 1. Christopher J. Woolverton, Linda Sherwood, Joanne Willey Prescott LM Harley JP and Klein DA (2016). Microbiology (10th edition) McGraw-Hill Education. 2. Schaechter M and Leaderberg J (2009). The Desk encyclopedia of Microbiology (3rd edition) Elseiver Academic press, California. 3. John Webster (January 25, 2007). Introduction to Fungi. (3rd edition). Cambridge University Press, Cambridge. 4. Nester, E.W., Roberts, C.V. and Nester, M.T. (2015). Microbiology, A human perspective.(8th Edition) McGraw-Hill Education (January 6, 2015) 5. Madigan MT Martinko. JM and Parker J Brock TD (2017). Biology of Microorganisms. (15th edition). Pearson 6. Holt, J.S., Kreig, N.R., Sneath, P.H.A and Williams, S.T. Bergey’s Manual of Determinative Bacteriology (9th Edition), Williams and Wilkins, Baltimore. 7. Mara D. and Horan N. (2013). The Handbook of Water and Waste-Water Microbiology. (3rd edition) Academic CRC Press. MSc Microbiology: Semester 1 CELL & MOLECULAR BIOLOGY Course Code: CMB102 Total Number of Credits: 03 Cell and Molecular Biology aims to introduce the fundamentals and basic biology of life. The contents will help students understand the features and differences between a prokaryotic and eukaryotic cell. It will elaborate the central dogma of the cell i.e., gene expression viz. transcription and translation across both prokaryotes and eukaryotes. Unit 1: The molecules of life, the architecture of cells: Cell theory, Emergence of modern cell biology, Structure of prokaryotic and eukaryotic cells- cell wall, cell membrane, cell organelles - organization and functions, Cell cycle events - Molecular cell biology - protein structure and function, Hierarchical structure of proteins - folding, modification and degradation, functional design of proteins - membrane proteins - purification, detection and characterization. Unit 2: Biosynthesis of macromolecules - Biomembranes and subcellular organization of prokaryotic and eukaryotic cells - cell architecture - Cell signaling – types, Chemical signals and cellular receptors, G Protein-linked receptors, Protein kinase-associated receptors, Growth factors as messengers, Cell signals and Apoptosis, Cytoskeleton: microfilaments-intermediate filaments-microtubules. Unit 3: Prokaryotic and eukaryotic DNA replication, mechanisms of DNA replication, fidelity of replication, enzymes and proteins involved in DNA replication. Types of gene mutations. Suppression, Transposable Genetic Elements, Ames’ test. DNA damage and repair mechanisms, DNA repair and aging, DNA repair modulation. Unit 4: Prokaryotic transcription: RNA polymerase, holoenzyme and apoenzyme, sigma factors, details of initiation, elongation, termination. Eukaryotic transcription: Types of RNA polymerases. Promoter of RNA polymerase II. Enhancers. General and inducible transcription factors. Post- translational modification: mRNA processing, processing, capping, cleavage and poly- adenylation, splicing of nuclear pre-mRNA, mRNA stability. Unit 5: Gene code: characteristics, deciphering the code. Protein biosynthesis: Prokaryotic and eukaryotic translation, the translational machinery, mechanism of initiation, elongation and termination. Regulation of expression in eukaryotes: Britten-Davidson model. DNA binding and activation domains of transcription factors. Packaging of chromosomes and its relation to transcription
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