The Legacy of Dolly at 20

Total Page：16

File Type：pdf, Size：1020Kb

SCIENTIFIC SYMPOSIUM COMING OF AGE: THE LEGACY OF DOLLY AT 20 09:00 Coffee & Registration Welcome Address 09:30 Prof Sir Tim O’Shea, Principal of the University of Edinburgh Session 1 Professor Sir Ian Wilmut Keynote lecture 09:45 MRC Centre for Regenerative Medicine Chair: Prof David Hume University of Edinburgh, UK Coffee Break 10:15 Session 2 Chair Session Intro, Prof Bruce Whitelaw From Dolly to Engineered Farm Animals 10:40 The Roslin Institute, University of Edinburgh Chair: Prof Bruce Whitelaw Prof Goetz Laible 10:45 AgReasearch, Ruakura, New Zealand 11:15 Dr Chris Proudfoot The Roslin Institute, University of Edinburgh Dr Lissa Heron 11:35 The Roslin Institute, University of Edinburgh 11:55 Prof Angelika Schnieke Technical University Munich, Germany Lunch with posters and industry exhibition 12:30 Session 3 Chair Session Intro, Prof Ian Chambers 14:00 Alternatives to cloning for altering cell identity MRC Centre for Regenerative Medicine, University of Edinburgh Chair: Prof. Ian Chambers Prof Shinya Yamanaka Center for iPS Cell Research and Application 14:05 Kyoto University, Nobel Prize Laureate Physiology / Medicine 2012) Dr Abdenour Soufi 14:35 MRC Centre for Regenerative Medicine, University of Edinburgh Dr Sally Lowell 14:55 MRC Centre for Regenerative Medicine, University of Edinburgh Prof Marius Wernig 15:15 Stanford University, USA Coffee Break 15:45 Session 4 Taking stem cell science towards the clinic 16:15 Chair Session Intro, Prof Stuart Forbes Chair: Prof. Stuart Forbes MRC Centre for Regenerative Medicine, University of Edinburgh Dr Paul Tesar 16:20 Case Western Reserve University, Cleveland, Ohio, USA 16:50 Prof Clare Blackburn MRC Centre for Regenerative Medicine, University of Edinburgh Prof Andrew Jackson MRC Human Genetics Unit, Institute of Genetics and 17:10 Molecular Medicine, University of Edinburgh 17:30 Prof Marc van de Wetering Princess Maxima Center, Utrecht, Netherlands Closing remarks: Prof David Hume The Roslin Institute, University of Edinburgh 18:00 Reception until 19:00 .

Copy Link

Recommended publications

1 Genomic Analysis of Family Data Reveals Additional Genetic Effects On
bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Genomic analysis of family data reveals additional genetic effects on intelligence and personality W. David Hill1,2*†, Ruben C. Arslan3,4†, Charley Xia†5, Michelle Luciano1,2, Carmen Amador5, Pau Navarro5, Caroline Hayward5, Reka Nagy5, David J. Porteous1,6,8, Andrew M. McIntosh1,9, Ian J. Deary1,2, Chris S. Haley5,10, and Lars Penke1,3,4 1 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK 2 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK 3 Georg Elias Müller Institute of Psychology, Georg August University Göttingen, Germany 4 Leibniz ScienceCampus Primate Cognition, Göttingen, Germany 5 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK 6 Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK 8 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh 9 Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF 10 The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, UK * Corresponding author † These authors contributed equally Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK, T: +44 (131) 650 8405, E: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017.
[Show full text]
Papers Will Be Uploaded in Due Course
THE UNIVERSITY OF EDINBURGH BUSINESS FOR MEETING OF THE UNIVERSITY COURT to be held in the Raeburn Room, Old College on Monday, 9 December 2013 at 2.00 p.m. A buffet lunch will be available at 1.00 p.m. in the Lord Provost Elder Room, Old College This meeting of Court will be preceded by a presentation on the Research Excellence Framework (REF2014) delivered by Mrs Tracey Slaven, Deputy Secretary, Strategic Planning. A FORMAL BUSINESS 1. Minute of the meeting held on 4 November 2013 A1 2. Senate Assessor A2 B PRINCIPAL'S BUSINESS 1. Principal’s Communications B1 2. Vice-Principal update B2 C SUBSTANTIVE ITEMS 1. Report of the Finance and General Purposes Committee .1 Comments on the Report of the Central Management Group C1.1 .2 Report on Other Items C1.2 2. EUSA President’s Report C2 3. Risk Management Committee year end report C3 4. Risk Management – post year end Assurance Statement C4 5. Audit Committee Annual Report C5 6. Reports and Financial Statements .1 Annual Report and Accounts for year ended 31 July 2013 C6.1 .2 Letter of Representation C6.2 .3 Review of 2012/2013 Outturn versus Forecast C6.3 7. 2014-2017 Draft Outcome Agreement C7 8. Strategic Plan: Targets and KPIs Progress Report C8 9. Annual Review 2012-2013 C9 10. Report from Remuneration Committee C10 11. Report from Knowledge Strategy Committee C11 D ITEMS FOR FORMAL APPROVAL OR NOTE 1. Draft Resolutions D1 2. Risk Management Committee – Terms of Reference D2 3. Donations and Legacies D3 4.
[Show full text]
BSCB Newsletter 2019A:BSCB Aut2k7
2019 BSCB Magazine BRITISH SOCIETY FOR CELL BIOLOGY 2019 CONTENTS BSCB Magazine News 2 Book reviews 8 Features 9 Meeting Reports 21 Summer students 25 Society Business 32 Editorial Front cover: microscopic Welcome to the 2019 BSCB Magazine! This year Mustafa Aydogan (University of Oxford), as well as to structure of pectoral fin and Susana and Stephen are filling in for our Newsletter BSCB postdoc poster of the year winners Dr Anna hypaxial muscles of a zebrafish Editor Ann Wheeler. We hope you will enjoy this Caballe (University of Oxford) and Dr Agata Gluszek- Danio rerio larvae at four days year’s magazine! Kustusz (University of Edinburgh). post fertilization. The immunostaining highlights the This year we had a number of fantastic one day In 2019, we will have our jointly BSCB-BSDB organization of fast (red) and meetings sponsored by BSCB. These focus meetings Spring meeting at Warwick University from 7th–10th slow (green) myosins. All nuclei are great way to meet and discuss your science with April, organised by BSCB members Susana Godinho are highlighted in blue (hoechst). experts in your field and to strengthen your network of and Vicky Sanz-Moreno. The programme for this collaborators within the UK. You can read more about meeting, which usually provides a broad spectrum of these meetings in the magazine. If you have an idea themes, has a focus on cancer biology: cell for a focus one day meeting, check how to apply for migration/invasion, organelle biogenesis, trafficking, funding on page 4. Our ambassadors have also been cell-cell communication.
[Show full text]
'Coming of Age: the Legacy of Dolly At
‘Coming of Age: The Legacy of Dolly at 20’ Friday 2nd September 2016 The Roslin Institute Auditorium, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK 9:00 – 9:30 Coffee & Registration 9:30 Welcome Address: Prof Sir Tim O’Shea, Principal of the University of Edinburgh Session 1: ‘Keynote lecture’ 9.40 Chair Session Intro, Prof David Hume, Director, The Roslin Institute 9:45 Prof Sir Ian Wilmut, MRC Centre for Regenerative Medicine, University of Edinburgh, UK ‘Dolly the first clone of an adult animal’ 10:15 – 10:40 Coffee Break Session 2: ‘From Dolly to Engineered Farm Animals' 10:40 Chair Session Intro, Prof Bruce Whitelaw, The Roslin Institute, University of Edinburgh 10:45 Prof Goetz Laible, AgReasearch, Ruakura, New Zealand: ‘Tailoring milk composition for human needs with progressively improved genetic engineering strategies’ 11:15 Dr Chris Proudfoot, The Roslin Institute, University of Edinburgh: ‘Editing the livestock genome’ 11:35 Dr Lissa Heron, The Roslin Institute, University of Edinburgh: ‘Eggcellent therapeutics: chicken bioreactors for the production of pharmaceutical proteins’ 11:55 Prof Angelika Schnieke, Technical University Munich, Germany: ‘The sheep got the glory but now the pigs are doing the work’ 12:30 – 14.00 Lunch with posters and industry exhibition ‘Coming of Age: The Legacy of Dolly at 20’ Session 3: ‘Alternatives to cloning for altering cell identity’ 14:00 Chair Session Intro, Prof Ian Chambers, MRC Centre for Regenerative Medicine, University of Edinburgh 14:05 Prof Shinya Yamanaka,
[Show full text]
Edit Summer 2009
SUMMER 09 THE ALUMNI MAGAZINE INCLUDING BILLET & GENERAL COUNCIL PAPERS The Origin of Genius Charles Darwin’s Edinburgh connection ALSO INSIDE Edinburgh’s innovative teaching leads the way Edit meets the winners of the Principal’s Medal The University of Edinburgh Forever a part of it Your links with Edinburgh don’t end when you leave the University – you’re an Edinburgh alumnus for life – so stay in touch and reap the benefits! The Alumni Card What will it do for you? Have you got your new-look Alumni Card • Receive 15% off hire of University • Enjoy free access to the University’s yet? As an alumnus you are eligible for the venues, accommodation and catering many libraries and their printed new card, which replaces the Edinburgh for weddings, parties, meetings and, collections – as well as 50% off Passport and allows discounted access of course, reunions! borrowing rights. to many of the University’s outstanding • Enjoy a 25% discount at the • Receive a 20% discount on all books facilities. The card also entitles you to University’s Centre for Sports and published by Edinburgh University a new range of discounts with partner Exercise – one of the Scotsman’s Press. organisations worldwide. Sign up at top five gyms in Scotland – which Get discounted rates with our partners www.ed.ac.uk/alumni. • offers you a wealth of fitness in the hotel and leisure industry all over classes, training, gym support, the world. We will be adding to our list climbing facilities, a circuit gym, of partners on a regular basis, so make playing fields, an outdoor activity sure you visit www.ed.ac.uk/alumni centre on Loch Tay and much more! for the latest offers.
[Show full text]
RSE Fellows Ordered by Area of Expertise As at 11/10/2016
RSE Fellows ordered by Area of Expertise as at 11/10/2016 HRH Prince Charles The Prince of Wales KG KT GCB Hon FRSE HRH The Duke of Edinburgh KG KT OM, GBE Hon FRSE HRH The Princess Royal KG KT GCVO, HonFRSE A1 Biomedical and Cognitive Sciences 2014 Professor Judith Elizabeth Allen FRSE, FMedSci, Professor of Immunobiology, University of Manchester. 1998 Dr Ferenc Andras Antoni FRSE, Honorary Fellow, Centre for Integrative Physiology, University of Edinburgh. 1993 Sir John Peebles Arbuthnott MRIA, PPRSE, FMedSci, Former Principal and Vice-Chancellor, University of Strathclyde. Member, Food Standards Agency, Scotland; Chair, NHS Greater Glasgow and Clyde. 2010 Professor Andrew Howard Baker FRSE, FMedSci, BHF Professor of Translational Cardiovascular Sciences, University of Glasgow. 1986 Professor Joseph Cyril Barbenel FRSE, Former Professor, Department of Electronic and Electrical Engineering, University of Strathclyde. 2013 Professor Michael Peter Barrett FRSE, Professor of Biochemical Parasitology, University of Glasgow. 2005 Professor Dame Sue Black DBE, FRSE, Director, Centre for Anatomy and Human Identification, University of Dundee. ; Director, Centre for Anatomy and Human Identification, University of Dundee. 2007 Professor Nuala Ann Booth FRSE, Former Emeritus Professor of Molecular Haemostasis and Thrombosis, University of Aberdeen. 2001 Professor Peter Boyle CorrFRSE, FMedSci, Former Director, International Agency for Research on Cancer, Lyon. 1991 Professor Sir Alasdair Muir Breckenridge CBE KB FRSE, FMedSci, Emeritus Professor of Clinical Pharmacology, University of Liverpool. 2007 Professor Peter James Brophy FRSE, FMedSci, Professor of Anatomy, University of Edinburgh. Director, Centre for Neuroregeneration, University of Edinburgh. 2013 Professor Gordon Douglas Brown FRSE, FMedSci, Professor of Immunology, University of Aberdeen. 2012 Professor Verity Joy Brown FRSE, Provost of St Leonard's College, University of St Andrews.
[Show full text]
The Record 2012/13
The Record 2012/13 The Record 2012/13 contents 5 Letter from the Warden 6 The Fellowship 9 Fellowship Elections and Appointments 9 Fellows’ Obituaries 13 JCR & MCR Elections 13 Undergraduate Scholarships 15 Matriculation 18 College Awards and Prizes 21 Academic Distinctions 22 Higher Degrees 23 Fellows’ Publications 30 Sports and Games 35 Clubs and Societies 37 The Chapel 38 Parishes Update 39 The Library and Archive 40 Old Members’ Obituaries 52 News of Old Members letter from the warden I write this as the autumn season is clearly beginning and I watch that change through the leaves of the marvellous copper beech in Pusey Quad. Sadly, during August, a large branch fell off in the middle of the night, victim so the experts said to the phenomenon of ’summer drop’. Much to our relief we have been assured that the tree is otherwise in good health, subject to some pruning to balance what remains. So far as I’m aware that is the only negative change in the physical aspect of the College that I need to report. Work has continued on aspects of the fabric to ensure that the original Butterfield buildings are preserved and, where appropriate, enhanced. This has included a further phase of refurbishment of the rooms in Liddon Quad and of some of the floor tiling in the Hall. The main elements of a new lighting scheme in the Chapel have also been completed and, as a result, three valuable outcomes have been achieved: the mosaics are now visible,The Light of the World is lit to much better effect and the choir is able to read the music its members so ably perform.
[Show full text]
RSE Fellows As at 11/10/2016
RSE Fellows as at 11/10/2016 HRH Prince Charles The Prince of Wales KG KT GCB Hon FRSE HRH The Duke of Edinburgh KG KT OM, GBE Hon FRSE HRH The Princess Royal KG KT GCVO, HonFRSE Elected Name 2000 Professor Samson Abramsky FRS FRSE, Professor, Oxford University Computing Laboratory, University of Oxford. 2007 Professor Graeme John Ackland FRSE, Professor of Computer Simulation/Head of Condensed Matter Group, University of Edinburgh. 1988 Professor James Hume Adams FRSE, Former Titular Professor of Neuropathology, Southern General Hospital (Glasgow). 1983 Professor Roger Lionel Poulter Adams FRSE, Former Professor of Nucleic Acid Biochemistry, University of Glasgow. 2003 Dr James Adamson CBE, FRSE, Non Executive Chairman, Home Media Networks. Non Executive Director, RRK Technology; Honorary President, Fife Society for the Blind. 2006 Dr Paul Addison FRSE, Honorary Fellow, University of Edinburgh. 2003 Professor Mark Ainsworth FRSE, Professor of Applied Mathematics, Brown University. 2014 Professor James Stewart Aitchison CorrFRSE, Professor and Nortel Chair in Emerging Technology, University of Toronto. 1968 Professor John Aitchison FRSE, Emeritus Professor of Statistics, University of Hong Kong. 1995 Professor Robert John Aitken FRSE, Professor of Biological Sciences, Newcastle University. Director, ARC Centre of Excellence in Biotechnology and Development, Newcastle University; Honorary Professor, Faculty of Medicine, University of Edinburgh. 2008 Professor Stephen Derek Albon FRSE, Environmental Sustainability Champion, The James Hutton Institute. Co-chair, UK National Ecosystem Assessment; Member, Scottish Biodiversity Strategy - Natural Capital Group. 2002 Professor Dario Alessi FRS FRSE, FMedSci, Director, MRC Protein Phosphorylation Unit, University of Dundee. 2003 Professor Alan Alexander OBE, FRSE, FAcSS, Emeritus Professor of Local and Public Management, University of Strathclyde.
[Show full text]
Bulletin Spring 2014
THE UNIVERSITY of EDINBURGH SPRING 2014 bulletinTHE UNIVERSITY OF EDINBURGH STAFF MAGAZINE Ahead of the game Jim Aitken on how higher education helps our athletes to excel – page 12 Inspiring A unique Help or Competition change perspective hindrance? & giveaway We celebrate the diversity International students Lydia Plowman looks at Your chance to win tasty and influence of our female share their insights into children’s learning in the treats from two fantastic colleagues – page 8 Edinburgh life – page 16 digital age – page 18 local cafes – page 27 editorial... bulletin editorial PUBLICATION DETAILS As another academic year comes to a close, colleagues across the colleges and Published by: Communications and support groups can reflect on a great number of accolades and achievements. Marketing, The University of Edinburgh In this edition of bulletin we share just some of your recent success stories. CONTACT US From dinosaur discoveries and living organ regeneration (pages 6–7) to winners bulletin of the EUSA Teaching Awards (page 4), we highlight our research and teaching Communications and Marketing The University of Edinburgh excellence and innovation. We also reflect on the University’s progress with C Floor, Forrest Hill Building enhancements to the student experience (page 26). 5 Forrest Hill Edinburgh EH1 2QL, UK We celebrate the commitment of our long-serving staff members (pages 14–15) and also introduce a few new faces (pages 20–22, 25). E: [email protected] T: +44 (0)131 650 9747 Looking ahead, we preview Edinburgh’s chances at the Glasgow 2014 Commonwealth Games (opposite), and Jim Aitken, Director of Sport, outlines SUBMISSION DETAILS how higher education is helping our sporting stars to excel on the world stage If you would like to submit an idea for (pages 12–13).
[Show full text]
Graduate Research and Training
GRADUATE RESEARCH & TRAINING HANDBOOK 2018 GRADUATE RESEARCH & TRAINING HANDBOOK 2018 Welcome IGMM Graduate Research and Training Contacts Staff Student Liaison Committee/Officer 1 40,000 5.0 0 0 !"#$%&$%'& & 5.0 Number of promoters ()*+&,)-).%+/0-&1(2&,)-0+34) 546)-0+34)&7%44/-,8 & of promoters Proportion & 1 9)-07)&:);")-</-,&6%:&')<07)&.)$%+/=)$3&<6)%4>&%-#&<$0:)&+0&%&7/$$/0-&4)04$)& 30,000 Matched expression Vagina 6%=)&6%#&+6)/.&,)-07)&:);")-<)#8&?0&/-+).4.)+&+6/:&7%::/=)&%70"-+&0@&Divergent expression Neurons Diminished promoter activity Epididymis Ovary, adult Ovary, Testis, adult Testis, CD8+ T cells CD8+ T cells CD4+ T Uterus, adult Uterus, - cerebellum Thymus, fetal Thymus, CD19+ B cells CD19+ B No promoter activity Housekeeping /[email protected]%+/0->&0".&$%'&#)=)$04:&)@@/</)-+&7)+60#:&@0.&7)%:"./-,&%-#&4.)#/<+/-,&+6)& Placenta, adult adly-expressed - hippocampus egulatory T cells T egulatory Inserted promoter sequence Tissue-restricted Cerebellum, adult Cerebellum, adult cord, Spinal Bro onventional T cells onventional )@@)<+:&0@&,)-)+/<&=%./%+/0-8&A)&:3-+6):/B)&$%.,)&<0$$)<+/0-:&0@&7"+%+)#&,)-):>&%-#& adult oblongata, lla Deleted promoter sequence adult Diencephalon, Hippocampus, adult Hippocampus, Ambiguous promoter alignment adult brain, Olfactory Naive r Astrocytes #)=)$04&6/,65+6.0",64"+&%::%3:&+0&7)%:".)&+6)&)@@)<+:&0@&7"+%+/0-:&0-& Medu Naive c 70$)<"$%.&%-#&<)$$"$%.&46)-0+34):>&:"<6&%:&4.0+)/-&%-#&1(2&%'"-#%-<)>Astrocytes &4.0+)/- 5 1(2&/-+).%<+/0-:>&%-#&@/+-)::&CD"<6+%&)+&%$8>&E</)-<)>&FGHIJ8&A)&":)&%&=%./)+3&0@& )*4)./7)-+%$&+)<6-/;"):>&/-<$"#/-,&,)-)&:3-+6):/:>&-)*+ 5,)-).%+/0-&:);")-</-,>& 7/<.0%..%3:>&%-#&%"+07%+)#&7/<.0:<043>&%-#&)*4)./7)-+%$&:3:+)7:&/-<$"#/-,& '%<+)./%>&3)%:+>&%-#&7%77%$/%-&<)$$:8& & & & & & 1 GRADUATE RESEARCH & TRAINING HANDBOOK 2018 Welcome In the first instance you will mainly deal with We are delighted to welcome you to your your supervisors, Graduate Convenor or Nick PhD programme at the Institute of Genetics Gilbert (Director of Graduate Research and and Molecular Medicine.
[Show full text]
2019-Brochure
FREE EVENT SAT 28 & SUN 29 SEPTEMBER 2019 Edinburgh Doors Open Day 2019 includes East Lothian venues Saturday 28 and Sunday 29 September Support the Cockburn Association and Edinburgh Doors Open Day Who are we? The Cockburn Association (The Edinburgh Civic Your support enables us to organise city wide Trust) is an independent charity which relies on the free events such as Doors Open Days, bringing support of its members to protect and enhance together Edinburgh’s communities in a celebration the amenity of Edinburgh. We have been working of our unique heritage. since 1875 to improve the built and natural All members of the Association receive an environment of the city – for residents, visitors and advance copy of the Doors Open Days workers alike. programme and invitations throughout the year We campaign to prevent inappropriate to lectures, talks and events. development in the City and to preserve the If you are interested in joining the Association, Green Belt, to promote sustainable development, visit us online at www.cockburnassociation.org.uk restoration and high quality modern architecture. or feel free to call or drop in to our offices at We are always happy to advise our members on Trunk’s Close. issues relating to planning. The Cockburn Association (The Edinburgh Civic Trust) The Cockburn Association is a registered Scottish charity, No: SC011544 For everyone who loves Edinburgh Trunk’s Close, 55 High Street, Edinburgh T: 0131 557 8686 1 THE NEW TOWN All lectures will be held at the French Institute of Scotland, Lecture Series 2019 West Parliament Square, Edinburgh EH1 1RF.
[Show full text]
MRC Investigators and Directors Directory of Research Programmes at MRC Institutes and Units Foreword
SUMMER 2021 MRC Investigators and Directors Directory of research programmes at MRC Institutes and Units Foreword I am delighted to introduce you to the exceptional To support the MRC Investigators and Directors researchers at our MRC Institutes and Units – the in advancing medical research, MRC provides MRC Investigators and their Directors. core funding to the MRC Institutes and University Units where they carry out their work. These In November 2020, MRC established the new title establishments cover a huge breadth of medical of “MRC Investigator” for Programme Leaders (PL) research from molecular biology to public health. and Programme Leader Track (PLT) researchers at As you will see from the directory, the MRC MRC Institutes and Units. These individuals are Investigators and Directors are making considerable world-class scientists who are either strong leaders advances in their respective fields through their in their field already (PLs) or are making great innovative and exciting research programmes. Their strides towards that goal (PLTs). Based on what accomplishments have been recognised beyond they have achieved in their research careers so far, MRC and many have been awarded notable prizes the title will no doubt become synonymous with and elected to learned societies and organisations. scientific accomplishment, impact and integrity. As well as being widely recognised within the MRC endeavours to do everything it can to support scientific and academic communities, the well- its researchers at all career stages. For this reason, established and newer title of “Director” and we chose not to distinguish between levels of “MRC Investigator”, respectively, are a signal seniority within the new title.
[Show full text]