RSE Fellows As at 11/10/2016
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A Second Second Wave?
Human Ties – A Second Second Wave? Katharine McCrossan As COVID-19 lockdown measures in Scotland continue to ease, concerns over a possible second wave do not. But how likely is a second wave of COVID-19 in Scotland, and what happened when the country was faced with a second wave of infections during the 1918 Influenza Pandemic over a hundred years prior? On 16 June 2020, Nicola Sturgeon warned that a ‘reckless relaxation of lockdown’ must be resisted. Lifting restrictions prematurely would, according to the First Minister, risk the resurgence of the virus and cost more lives and the country’s economic productivity.1 In contrast, the Emeritus Professor of bacteriology at the University of Aberdeen, Hugh Pennington, suggested that the evidence ‘supporting the notion of a second wave or peak…that would swamp the NHS’, was ‘very weak’. In his opinion, it is more likely that there would be a continuation of ‘infections, many in the form of localised outbreaks, but not waves or peaks’.2 The First Minister, however, is not alone in urging caution. ‘Europe should brace for a second wave’, reported The Guardian on 20 May 2020 in an interview with the director of the European Centre for Disease Prevention and Control, Dr Andrea Ammon. According to Dr Ammon, the likelihood of a second wave of coronavirus infections is no longer theoretical. Instead, the question is ‘when and how big’. Additionally, Dr Ammon added that as infection 1 ‘Coronavirus: Sturgeon warns against 'reckless' easing of lockdown’, BBC News <https://www.bbc.co.uk/news/uk-scotland-52967726> [accessed 16 June 2020]. -
This Thesis Has Been Submitted in Fulfilment of the Requirements for a Postgraduate Degree (E.G
This thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given. Structural and Magnetic Properties of the Geometrically Frustrated 3d and 5d = 1 s 2 Double Perovskites Sr2CuWO6, Ba2YWO6 and LaSrMgWO6 Oliver Burrows Doctor of Philosophy The University of Edinburgh August 2016 Lay Summary of Thesis With the development of quantum mechanics in the early 20th century, an understanding of the microscopic behaviour of magnetic materials was gained. With the revelations afforded by this discipline, however, came a tendency in some quarters towards a reductionist viewpoint of science: that chemistry was merely physics applied on a larger scale. Similarly, biology was considered by some to be be merely “scaled-up” chemistry, and psychology was simply a consequence of the rules governing biology, applied on the scale of an organism. Such a simplistic argument ignores the concept of emergent phenomena. -
1 Genomic Analysis of Family Data Reveals Additional Genetic Effects On
bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Genomic analysis of family data reveals additional genetic effects on intelligence and personality W. David Hill1,2*†, Ruben C. Arslan3,4†, Charley Xia†5, Michelle Luciano1,2, Carmen Amador5, Pau Navarro5, Caroline Hayward5, Reka Nagy5, David J. Porteous1,6,8, Andrew M. McIntosh1,9, Ian J. Deary1,2, Chris S. Haley5,10, and Lars Penke1,3,4 1 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK 2 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK 3 Georg Elias Müller Institute of Psychology, Georg August University Göttingen, Germany 4 Leibniz ScienceCampus Primate Cognition, Göttingen, Germany 5 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK 6 Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK 8 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh 9 Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF 10 The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, UK * Corresponding author † These authors contributed equally Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK, T: +44 (131) 650 8405, E: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017. -
All Notices Gazette
ALL NOTICES GAZETTE CONTAINING ALL NOTICES PUBLISHED ONLINE ON 30 JUNE 2015 PRINTED ON 1 JULY 2015 PUBLISHED BY AUTHORITY | ESTABLISHED 1665 WWW.THEGAZETTE.CO.UK Contents State/2* Royal family/ Parliament & Assemblies/ Honours & Awards/ Church/3* Environment & infrastructure/4* Health & medicine/ Other Notices/9* Money/10* Companies/11* People/69* Terms & Conditions/94* * Containing all notices published online on 30 June 2015 STATE STATE Honours & awards State Awards THE ROYAL VICTORIAN ORDER 2360003CENTRAL CHANCERY OF THE ORDERS OF KNIGHTHOOD St. James’s Palace, London SW1 30 June 2015 THE QUEEN has been graciously pleased to make the following appointments to the Royal Victorian Order: KCVO To be a Knight Commander: Sir Simon Gerard McDONALD, KCMG. CVO To be a Commander: Nicholas PICKARD. LVO To be a Lieutenant: Peter RUSKIN. MVO To be a Member: William SMITH, RVM. (To be dated 23 June 2015) (2360003) 2 | CONTAINING ALL NOTICES PUBLISHED ONLINE ON 30 JUNE 2015 | ALL NOTICES GAZETTE CHURCH CHURCH REGISTRATION FOR SOLEMNISING MARRIAGE 2360018A building certified for worship named Croydon Islamic Community Trust, Ground Floor Premier House, 89 London Road, Croydon, in the registration district of Croydon in the London Borough of Croydon, was on 10th April 2015 registered for solemnizing marriages therein, pursuant to Section 41 of the Marriage Act 1949 (as amended by Section 1(1) of the Marriage Acts Amendment Act 1958) Superintendent Registrar 5 May 2014 (2360018) ALL NOTICES GAZETTE | CONTAINING ALL NOTICES PUBLISHED ONLINE ON 30 JUNE 2015 | 3 ENVIRONMENT & INFRASTRUCTURE ENVIRONMENTAL PROTECTION ENVIRONMENT & 2360562THE SCOTTISH GOVERNMENT ENVIRONMENTAL ASSESSMENT (SCOTLAND) ACT 2005: SECTION 8(1) SCREENING DETERMINATION INFRASTRUCTURE CIRCULAR ECONOMY CONSULTATION The Scottish Government has determined that the above Circular Economy Consultation is likely to have significant environmental ENERGY effects and that a Strategic Environmental Assessment is therefore required. -
The Royal Society of Edinburgh Issue 8 • Winter 2003/2004
news THE ROYAL SOCIETY OF EDINBURGH ISSUE 8 • WINTER 2003/2004 RESOURCE THE NEWSLETTER OF SCOTLAND’S NATIONAL ACADEMY RSE Agrees …Science Education Matters The first report of the independent expert group, the Scottish Science Advisory Committee (SSAC), Why Science Education Matters, published in November 2003, identifies a range of measures which seek to make science education in Scottish schools a matter of high priority. The Royal Society of Edinburgh (RSE) welcomes this report and recognises the recruitment crisis faced by school science departments. The Society, with funding from the Scottish Executive, hopes to help contribute, in part, to reversing this problem by offering Scotland’s science and careers teachers Teaching Fellowships. This new scheme offers teachers the chance to undertake exciting projects in business, industry and research and aims to support them in encouraging higher-level science studies. Professor John Coggins, RSE Vice-President and Chair of the SSAC’s working group, said: Scotland is attempting to develop new science-based industries at a time when fewer students are applying to study science. It is vitally important to increase the number of science graduates. This new scheme will help science teachers become more aware of the latest developments in science and of the exciting opportunities for careers in science which they will be able to transmit to their pupils. The RSE believes that working together with other key bodies in Scotland in strategic partnership is the best way forward and actively promotes the education of young people throughout Scotland. Its programme of events for primary and secondary school students is designed to stimulate and develop an early interest in science, society and culture. -
Papers Will Be Uploaded in Due Course
THE UNIVERSITY OF EDINBURGH BUSINESS FOR MEETING OF THE UNIVERSITY COURT to be held in the Raeburn Room, Old College on Monday, 9 December 2013 at 2.00 p.m. A buffet lunch will be available at 1.00 p.m. in the Lord Provost Elder Room, Old College This meeting of Court will be preceded by a presentation on the Research Excellence Framework (REF2014) delivered by Mrs Tracey Slaven, Deputy Secretary, Strategic Planning. A FORMAL BUSINESS 1. Minute of the meeting held on 4 November 2013 A1 2. Senate Assessor A2 B PRINCIPAL'S BUSINESS 1. Principal’s Communications B1 2. Vice-Principal update B2 C SUBSTANTIVE ITEMS 1. Report of the Finance and General Purposes Committee .1 Comments on the Report of the Central Management Group C1.1 .2 Report on Other Items C1.2 2. EUSA President’s Report C2 3. Risk Management Committee year end report C3 4. Risk Management – post year end Assurance Statement C4 5. Audit Committee Annual Report C5 6. Reports and Financial Statements .1 Annual Report and Accounts for year ended 31 July 2013 C6.1 .2 Letter of Representation C6.2 .3 Review of 2012/2013 Outturn versus Forecast C6.3 7. 2014-2017 Draft Outcome Agreement C7 8. Strategic Plan: Targets and KPIs Progress Report C8 9. Annual Review 2012-2013 C9 10. Report from Remuneration Committee C10 11. Report from Knowledge Strategy Committee C11 D ITEMS FOR FORMAL APPROVAL OR NOTE 1. Draft Resolutions D1 2. Risk Management Committee – Terms of Reference D2 3. Donations and Legacies D3 4. -
(G)ARCH Processes and the Phenomenon of Misleading and Unambiguous Signals
(G)ARCH processes and the phenomenon of misleading and unambiguous signals Ana Beatriz Torres de Sousa Thesis to obtain the Master of Science Degree in Mathematics and Applications Supervisor: Prof. Manuel Jo˜ao Cabral Morais Examination Committee Chairperson: Prof. Ant´onio Manuel Pacheco Pires Supervisor: Prof. Manuel Jo˜ao Cabral Morais Members of the Committee: Prof. Patr´ıcia Alexandra de Azevedo Carvalho Ferreira e Pereira Ramos December 2015 Acknowledgments During the preparation of this dissertation, I received the help and support of several people to whom I would like to thank. First of all, I want to express my genuine gratitude to my supervisor, Professor Manuel Cabral Morais, for his guidance, constructive criticism, proofreading and specially for his patience during our weekly and stimulating meetings via Skype. My thanks are also extensive to: Professor Yarema Okhrin because without his programming sug- gestion I would have waited much longer for the simulations to end; and Professor Wolfgang Schmid for providing crucial critical values and, thus, saving me from excruciating computations and time consuming simulations. This thesis could not have been written without the support and infinite patience of my family and friends. I am deeply grateful to: my parents, Manuela and Fernando, for always being there pushing me forward; my sister Rita who showed me that even the hardest obstacles can be overcome with persistence; and my grandmother Alice who always believed in me even when I did not. i ii Resumo Uma s´erie temporal ´euma sequˆencia de observa¸c˜oes ordenadas no tempo. No estudo destas sequˆencias, ´enecess´ario reconhecer explicitamente a importˆancia da ordem pela qual as observa¸c˜oes s˜ao recolhidas, logo recorrer `aan´alise e aos modelos de s´eries temporais. -
CFE-Cmstatistics 2020 Book of Abstracts
CFE-CMStatistics 2020 PROGRAMME AND ABSTRACTS 14th International Conference on Computational and Financial Econometrics (Virtual CFE 2020) http://www.cfenetwork.org/CFE2020 and 13th International Conference of the ERCIM (European Research Consortium for Informatics and Mathematics) Working Group on Computational and Methodological Statistics (Virtual CMStatistics 2020) http://www.cmstatistics.org/CMStatistics2020 19 – 21 December 2020 Computational and Methodological Statistics CMStatistics Computational and CFENetwork Financial Econometrics ⃝c ECOSTA ECONOMETRICS AND STATISTICS. All rights reserved. I CFE-CMStatistics 2020 ISBN 978-9963-2227-9-7 ⃝c 2020 - ECOSTA ECONOMETRICS AND STATISTICS All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any other form or by any means without the prior permission from the publisher. II ⃝c ECOSTA ECONOMETRICS AND STATISTICS. All rights reserved. CFE-CMStatistics 2020 International Organizing Committee: Ana Colubi, Erricos Kontoghiorghes and Manfred Deistler. CFE 2020 Co-chairs: Anurag Banerjee, Scott Brave, Peter Pedroni and Mike So. CFE 2020 Programme Committee: Knut Are Aastveit, Alessandra Amendola, David Ardia, Josu Arteche, Anindya Banerjee, Travis Berge, Mon- ica Billio, Raffaella Calabrese, Massimiliano Caporin, Julien Chevallier, Serge Darolles, Luca De Angelis, Filippo Ferroni, Ana-Maria Fuertes, Massimo Guidolin, Harry Haupt, Masayuki Hirukawa, Benjamin Hol- cblat, Rustam Ibragimov, Laura Jackson Young, Michel Juillard, Edward Knotek, Robinson Kruse-Becher, Svetlana Makarova, Ilia Negri, Ingmar Nolte, Jose Olmo, Yasuhiro Omori, Jesus Otero, Michael Owyang, Alessia Paccagnini, Indeewara Perera, Jean-Yves Pitarakis, Tommaso Proietti, Artem Prokhorov, Tatevik Sekhposyan, Etsuro Shioji, Michael Smith, Robert Taylor, Martin Wagner and Ralf Wilke. CMStatistics 2020 Co-chairs: Tapabrata Maiti, Sofia Olhede, Michael Pitt, Cheng Yong Tang and Tim Verdonck. -
The Effect of Recombination on Background Selection*
Genet. Res., Camb. (1996), 61, pp. 159-174 With 3 text-figures Copyright © 1996 Cambridge University Press 159 The effect of recombination on background selection* MAGNUS NORDBORGf, BRIAN CHARLESWORTH AND DEBORAH CHARLESWORTH Department of Ecology & Evolution, The University of Chicago, 1101 E. 57th St, Chicago, IL 60637-1573, USA. Tel: (312) 702-1040, Fax: {312) 702-9740, E-mail: [email protected] (Received 3 July 1995 and in revised form 20 October 1995) Summary An approximate equation is derived, which predicts the effect on variability at a neutral locus of background selection due to a set of partly linked deleterious mutations. Random mating, multiplicative fitnesses, and sufficiently large population size that the selected loci are in mutation/selection equilibrium are assumed. Given these assumptions, the equation is valid for an arbitrary genetic map, and for an arbitrary distribution of selection coefficients across loci. Monte Carlo computer simulations show that the formula performs well for small population sizes under a wide range of conditions, and even seems to apply when there are epistatic fitness interactions among the selected loci. Failure occurred only with very weak selection and tight linkage. The formula is shown to imply that weakly selected mutations are more likely than strongly selected mutations to produce regional patterning of variability along a chromosome in response to local variation in recombination rates. Loci at the extreme tip of a chromosome experience a smaller effect of background selection than loci closer to the centre. It is shown that background selection can produce a considerable overall reduction in variation in organisms with small numbers of chromosomes and short maps, such as Drosophila. -
The Analysis of RNA-Seq Experiments Using Approximate Likelihood
The analysis of RNA-Seq experiments using approximate likelihood Daniel C. Jones A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2020 Reading Committee: Walter L. Ruzzo, Chair Sreeram Kannan Georg Seelig Program Authorized to Offer Degree: Paul G. Allen School of Computer Science & Engineering ©Copyright 2020 Daniel C. Jones University of Washington Abstract The analysis of RNA-Seq experiments using approximate likelihood Daniel C. Jones Chair of the Supervisory Committee: Walter L. Ruzzo Paul G. Allen School of Computer Science & Engineering The analysis of mRNA transcript abundance with RNA-Seq is a central tool in molecular biology research, but often analyses fail to account for the uncertainty in these estimates, which can be significant, especially when trying to disentangle isoforms or duplicated genes. Preserving uncertainty necessitates a full probabilistic model of the all the sequencing reads, which quickly becomes intractable, as experiments can consist of billions of reads. To overcome these limitations, we propose a new method of approximat- ing the likelihood function of a sparse mixture model, using a technique we call the Pólya tree transformation. We demonstrate that substituting this approximation for the real thing achieves most of the benefits with a fraction of the computational costs, leading to more accurate detection of differential transcript expression. 3 4 For Maddie. Let’s have some more normal ones. Contents 1 the analysis -
A History of the University of Manchester Since 1951
Pullan2004jkt 10/2/03 2:43 PM Page 1 University ofManchester A history ofthe HIS IS THE SECOND VOLUME of a history of the University of Manchester since 1951. It spans seventeen critical years in T which public funding was contracting, student grants were diminishing, instructions from the government and the University Grants Commission were multiplying, and universities feared for their reputation in the public eye. It provides a frank account of the University’s struggle against these difficulties and its efforts to prove the value of university education to society and the economy. This volume describes and analyses not only academic developments and changes in the structure and finances of the University, but the opinions and social and political lives of the staff and their students as well. It also examines the controversies of the 1970s and 1980s over such issues as feminism, free speech, ethical investment, academic freedom and the quest for efficient management. The author draws on official records, staff and student newspapers, and personal interviews with people who experienced the University in very 1973–90 different ways. With its wide range of academic interests and large student population, the University of Manchester was the biggest unitary university in the country, and its history illustrates the problems faced by almost all British universities. The book will appeal to past and present staff of the University and its alumni, and to anyone interested in the debates surrounding higher with MicheleAbendstern Brian Pullan education in the late twentieth century. A history of the University of Manchester 1951–73 by Brian Pullan with Michele Abendstern is also available from Manchester University Press. -
Using GC Content to Compare Recombination Patterns on the Sex
bioRxiv preprint doi: https://doi.org/10.1101/2020.05.22.110635; this version posted May 26, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. 1 1 GC content ms v4e: 8 May 2020 2 3 Using GC content to compare recombination patterns on the sex chromosomes and 4 autosomes of the guppy, Poecilia reticulata, and its close outgroup species 5 6 7 Authors: 8 Deborah Charlesworth (ORCID iD 0000-0002-3939-9122), Yexin Zhang, Roberta Bergero, Chay 9 Graham 1, Jim Gardner, Lengxob Yong 2 10 11 Institute of Evolutionary Biology, School of Biological Sciences, 12 University of Edinburgh, West Mains Road, EH9 3LF, U.K. 13 14 1 University of Cambridge, Department of Biochemistry, Sanger Building, 80 Tennis Ct Rd, 15 Cambridge CB2 1GA, UK 16 17 2 Centre for Ecology and Conservation, University of Exeter, Penryn, Falmouth, Cornwall, 18 TR10 9FE, UK 19 20 21 22 23 Corresponding author: [email protected] 24 25 26 27 28 bioRxiv preprint doi: https://doi.org/10.1101/2020.05.22.110635; this version posted May 26, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. 2 29 Summary/Abstract 30 Genetic and physical mapping of the guppy (P.