PRKAB1 [1F9G6] Cat. No.: 13-300

PRKAB1 Antibody [1F9G6]

Specifications

HOST SPECIES: Mouse

SPECIES REACTIVITY: Human, Monkey, Mouse, Rat

IMMUNOGEN: Recombinant protein of human PRKAB1

TESTED APPLICATIONS: ICC, IHC, IP, WB

WB: ,1:500 - 1:2000

IHC: ,1:50 - 1:200 APPLICATIONS: ICC: ,1:20 - 1:50

IP: ,1:50 - 1:200

POSITIVE CONTROL: 1) HeLa

2) PC-12

3) SH-SY5Y

4) NCI-H460

5) Jurkat

6) NIH/3T3

PREDICTED MOLECULAR Observed: 38kDa WEIGHT:

October 1, 2021 1 https://www.prosci-inc.com/prkab1-antibody-1f9g6-13-300.html Properties

PURIFICATION: Affinity purification

CLONALITY: Monoclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: PRKAB1

ALTERNATE NAMES: PRKAB1, AMPK beta 1, AMPK subunit beta-1, AMPKb, AMPK, AMPK beta -1 chain, HAMPKb

GENE ID: 5564

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this is a regulatory subunit of the AMP-activated protein (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non- catalytic beta and gamma subunits. AMPK is an important energy-sensing that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and BACKGROUND: beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key involved in regulating de novo biosynthesis of and . This subunit may be a positive regulator of AMPK activity. The and of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

ANTIBODIES FOR RESEARCH USE ONLY.

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