PRKAB1 Antibody [1F9G6] Cat. No.: 13-300
PRKAB1 Antibody [1F9G6]
Specifications
HOST SPECIES: Mouse
SPECIES REACTIVITY: Human, Monkey, Mouse, Rat
IMMUNOGEN: Recombinant protein of human PRKAB1
TESTED APPLICATIONS: ICC, IHC, IP, WB
WB: ,1:500 - 1:2000
IHC: ,1:50 - 1:200 APPLICATIONS: ICC: ,1:20 - 1:50
IP: ,1:50 - 1:200
POSITIVE CONTROL: 1) HeLa
2) PC-12
3) SH-SY5Y
4) NCI-H460
5) Jurkat
6) NIH/3T3
PREDICTED MOLECULAR Observed: 38kDa WEIGHT:
October 1, 2021 1 https://www.prosci-inc.com/prkab1-antibody-1f9g6-13-300.html Properties
PURIFICATION: Affinity purification
CLONALITY: Monoclonal
ISOTYPE: IgG
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.
Additional Info
OFFICIAL SYMBOL: PRKAB1
ALTERNATE NAMES: PRKAB1, AMPK beta 1, AMPK subunit beta-1, AMPKb, AMPK, AMPK beta -1 chain, HAMPKb
GENE ID: 5564
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non- catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and BACKGROUND: beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
ANTIBODIES FOR RESEARCH USE ONLY.
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