Published by Chonburi Cancer Center 300 Moo 2 Samed, Muang

Published by Chonburi Cancer Center 300 Moo 2 Samed, Muang, Chonburi 20000 Tel : (66) 3878-4001-5 ext 158 Fax : (66) 3844-5059 E mail address : contact @ ccc.in.th ISBN 978-974-422-360-9

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

CONTENTS

Page

List of Tables B

List of figures D

Foreword G

Acknowledgements H

List of Collaborators I

1. Introduction 1

2. Methods 9

3. Results 14

4. Oral cavity cancer 26

5. Colorectal cancer 29

6. Liver cancer 32

7. Lung cancer 35

8. Leukemia 38

9. Skin cancer 41

10. Breast cancer 44

11. Cervical cancer 47

12. Prostate cancer 50

13. Bladder cancer 53

14. Thyroid cancer 56

15. Lymphoma 59

16. Pathology 62

References 94

Appendix A 96

Appendix B 127 A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

LIST OF TABLES

Page

Table 1.1 Cancer in Five Continents (Thailand) 4

Table 1.2 Cancer in Thailand 4

Table 1.3 Population (2007) of the Eastern part of Thailand 7

Table 1.4 Increasing number of cases and percentage (1998-2002) after update 7

Table 3.1 Number of new cancer cases and ASR 16

Table 3.2 Comparisons of data quality 16

Table 3.3 Percentage of mortality and incidence ratios by sexes and sites, 22 Chonburi, 2003-2007

Table 3.4 Data quality: Percentage of histological verified and 23 death certificate only (Total), Chonburi, 2003-2007

Table 3.5 Data quality: Percentage of histological verified and 24 death certificate only (Male), Chonburi, 2003-2007

Table 3.6 Data quality: Percentage of histological verified and 25 death certificate only (Female), Chonburi, 2003-2007

Table 4.1 Data quality of oral cavity cancer, 2003-2007 26

Table 5.1 Data quality of colorectal cancer, 2003-2007 29

Table 6.1 Data quality of liver cancer, 2003-2007 32

Table 6.2 Morphology of liver cancer in Chonburi (2003-2007) 33

Table 7.1 Data quality of lung cancer, 2003-2007 35

Table 7.2 Morphology of lung cancer in Chonburi (2003-2007) 36

Table 8.1 Data quality of leukemia, (2003-2007) 38

Table 9.1 Data quality of skin cancer, 2003-2007 41

Table 9.2 Morphology of skin cancer in Chonburi 2003-2007 41

Table 10.1 Data quality of breast cancer, 2003-2007 44

Table 11.1 Data quality of cervical cancer, 2003-2007 47 B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 12.1 Data quality of prostate cancer, 2003-2007 50

Table 13.1 Data quality of bladder cancer, 2003-2007 53

Table 14.1 Data quality of thyroid cancer, 2003-2007 56

Table 14.2 Morphology of thyroid cancer in Chonburi (2003-2007) 56

Table 15.1 Data quality of lymphoma , 2003-2007 59

Table 16 Pathology according to sites and sexes of all cancer 62

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

LIST OF FIGURES

Page

Figure 1.1 Map of Chonburi, Thailand 1

Figure 1.2 Eastern Thailand 1

Figure 1.3 Population densities by district, Chonburi, Thailand.(Census 2000) 1

Figure 1.4 Population-based cancer registries in Thailand 8

Figure 2.1 Source of information and the registration process 13

Figure 3.1 Leading cancers of new cases 14

Figure 3.2 Age-specific incidence and mortality rates of all cancers 15

Figure 3.3 Leading cancers by age and sexes 17

Figure 3.4 Extension of all cancers by sexes . 18

Figure 3.5 Geographic distributions by districts and sexes of all cancers 19

Figure 3.6 Comparisons of ASR of all cancers to the others 19

Figure 3.7 Leading cancer deaths, 2003-2007 20

Figure 3.8 Trends of incidence and mortality rates of all cancers, (1998-2007) 20

Figure 3.9 Trends of incidence rates of leading cancers, (Male) 21

Figure 3.10 Trends of incidence rates of leading cancers, (Female) 21

Figure 4.1 Age-specific incidence and mortality rates of oral cavity cancer 27

Figure 4.2 Geographic distributions by districts and sexes of oral cavity cancer 27

Figure 4.3 Comparisons of oral cavity cancer to the others 28

Figure 4.4 Trends of incidence and mortality of oral cavity cancer (1998-2007) 28

Figure 5.1 Age-specific incidence and mortality rates of colorectal cancer 30

Figure 5.2 Geographic distributions by districts and sexes of colorectal cancer 30

Figure 5.3 Comparisons of colorectal cancer with the others 31

Figure 5.4 Trends of incidence and mortality of colorectal cancer (1998-2007) 31

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

LIST OF FIGURES (Continued)

Page

. Figure 6.1 Age-specific incidence and mortality rates of liver cancer 33

Figure 6.2 Geographic distribution by districts and sexes of liver cancer 33

Figure 6.3 Comparisons of liver cancer with the others 34

Figure 6.4 Trends of incidence and mortality of liver cancer (1998-2007) 34

Figure 7.1 Age-specific incidence and mortality rates of lung cancer 36

Figure 7.2 Geographic distribution by districts and sexes of lung cancer 36

Figure 7.3 Comparisons of lung cancer to the others 37

Figure 7.4 Trends of incidence and mortality of lung cancer (1998-2007) 37

Figure 8.1 Age-specific incidence and mortality rates of leukemia 39

Figure 8.2 Geographic distribution by districts and sexes of leukemia 39

Figure 8.3 Comparisons of leukemia to the others 40

Figure 8.4 Trends of incidence and mortality of leukemia (1998-2007) 40

Figure 9.1 Age-specific incidence and mortality rates of skin cancer 42

Figure 9.2 Geographic distribution by districts and sexes of skin cancer 42

Figure 9.3 Comparisons of skin cancer to the others 43

Figure 9.4 Trends of incidence and mortality of skin cancer (1998-2007) 43

Figure 10.1 Age-specific incidence and mortality rates of female breast cancer 45

Figure 10.2 Geographic distribution by districts of female breast cancer 45

Figure 10.3 Comparisons of female breast cancer to the others 46

Figure 10.4 Trends of incidence and mortality of female breast cancer (1998-2007) 46

Figure 11.1 Age-specific incidence and mortality rates of cervical cancer 47

Figure 11.2 Geographic distribution by districts of cervical cancer 48

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 11.3 Comparisons of cervical cancer with the others 48

Figure 11.4 Trends of incidence and mortality of cervical cancer (1998-2007) 49

Figure 11.5 Number of carcinoma in situ of cervix by year (1998-2007) 49

Figure 12.1 Age-specific incidence and mortality rates of prostate cancer 51

Figure 12.2 Geographic distribution by districts and sexes of prostate cancer 51

Figure 12.3 Comparisons of Prostate cancer to the others 52

Figure 12.4 Trends of incidence and mortality of Prostate cancer (1998-2007) 52

Figure 13.1 Age-specific incidence and mortality rates of bladder cancer 54

Figure 13.2 Geographic distribution by districts and sexes of bladder cancer 54

Figure 13.3 Comparisons of Bladder cancer to the others 55

Figure 13.4 Trends of incidence and mortality of bladder cancer (1998-2007) 55

Figure 14.1 Age-specific incidence and mortality rates of thyroid cancer 57

Figure 14.2 Geographic distribution by districts and sexes of thyroid cancer 57

Figure 14.3 Comparisons of thyroid cancer to the others 58

Figure 14.4 Trends of incidence and mortality of thyroid cancer (1998-2007) 58

Figure 15.1 Age-specific incidence and mortality rates of lymphoma 60

Figure 15.2 Geographic distribution by districts and sexes of lymphoma 60

Figure 15.3 Comparisons of lymphoma to the others 61

Figure 15.4 Trends of incidence and mortality of lymphoma (1998-2007) 61

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

FORWARD

Worldwide, approximately 10 millions people are diagnosed with cancer annually and more than 6 millions die of cancer every year; currently, over 22 millions in the world are cancer patients. In Thailand, cancer is the leading cause of death since 2000, (statistic reported from Ministry of Public Health, Thailand). The cancer registry is an important part of infrastructure in cancer service, to evaluation of cancer control programs in the provinces or in the country. Usually cancer affects all nation, the etiological factors are different in the difference geographical area. The striking variations in the risk of disease in geographical location and in different ethnic groups in the same locality have long been important in generating hypotheses about causation. Chonburi has so many industries especially Industrial Estate Authority of the East situation in this area. Cancer registry in this province should be performed for cancer incidence, cancer surveillance and cancer prevention. This monograph has aimed to provide researchers, and those who concerned with planning and evaluating services for the cancer in populations from many geographical location as possible.

Kitisak Thepsuwan, M.D. Director of Chonburi Cancer Center Department of Medical Service Ministry of Public Health

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

ACKNOWLEDGEMENTS

The authors would like to thank all collaborators who cooperated to send all information of cancer patients for this publication. The longstanding tradition of cooperation between the registry and clinicians, pathologists, nurses, medical record staffs, information specialists and hospital administrators were the most vital part in developing this project. Finally, thanks to registry team, director of all hospitals in Chonburi, personals of Burean of Health Policy and Strategy Ministry of Public Health of Thailand, which were the original sources of death from all causes (Death Certificates) used in these report. Special thanks to Dr. Adisai Pattatang Dr. Lak Sukpreedee and Sinenart Sontipong who started collection of cancer datas. We look forward to continue and increase our collaborative links and network with the all hospitals and the clinical community as a whole, as well as expanding our activities in liaison with cancer researchers, both in Thailand and aboard.

Nimit Martin, M.D. Honorary Membership of IACR (International Association for Cancer Registry), WHO Consultant of National Cancer Institute Consultant of Chonburi Cancer Center

Kitisak Thepsuwan, M.D. Director of Chonburi Cancer Center Department of Medical Services Ministry of Public Health

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

COLLABORATORS

1. Chonburi Cancer Center: 300 Moo2 Samed, Muang, Chonburi 20000

Nimit Martin, M.D. Consultant Kitisak Tepsuwan, M.D. Director Kesorn Pongpanich, R.N. Assistant director Natcha Srisoonthorn Assistant director Adisai Pattatang, M.D Consultant

Secretarial staff: Jitraporn Tanabodee, M.D. Chief, Cancer Registry Unit Apichat Teerapantuwat, M.D Napat Injumpa,MD Chokhew Tovanabutra, MD Tapana Tangshewinsirikul, MD Watcharee Jaroenphol, R.N. Orwan Laoaree Health Education Academic Oranuch Rakkuamdee R.N. Sakowdouen Samakketkarn Financial and Accounting Officer Benjamaporn Jittiworaphan R.N. Kitimaporn Yotarak R.N. Pirin Ninsonthi R.N. Koragoat Vicheanthead R.N. Numphueng Kongpit R.N. Pramote Petmaneechote Medical record Librarian Cherleomrit Prapapkam Medical record Librarian Somchai Cheransuk Coordinator Chanvit Intharachurith Ketsaraporn Putta Ratchada Boonpiya Jittaporn Rachkratok Suwina Duangtapiyachai

2. Provincial Public Health Service of Chonburi Prayasajja Rd., Bansuan, Muang, Chonburi 20000 Tel. 0-3827-6631-6 Fax. 0-3827-4932

Marunt Jirasatetasiri, M.D. Chonburi Provincial chief of Medical Office Nuannoy Thamkittikhun Health Technical specialist Nopmanee Sanguanpong Health Technical specialist Chanya Santimak Policy Plan Analysis

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

3. Chonburi Hospital 69 Moo 2 Sukhumwith Rd., Bansuan, Muang, Chonburi 20000 Tel. 0-3827-4200-6 Fax. 0-3893-1100

Chatree Tantiyawarong, M.D. Director Assada Teeyapant, M.D. Kesada Chandsawang, M.D. Surawut Charoenkajonchai, M.D. Dechwit Worasayan, M.D. Chaisit Sritongchai. M.D. Thitiwan Londee, M.D. Pornpoch Sriutaisiriwong, M.D. Sittichai Tantipaswasin, D.D.S. Papis Sa-ngiampornpanit, M.D. Ratana Tantranon, M.D. Kaimook Gosinthardjit, M.D. Somjaree Sripinit, R.N. Narumon Nakcharoen Statistician Ningrithai Banpot Statistician Chawewan Timarun Medical record Librarian Anong Ketsoponkoon Medical record Librarian Suprecda Inthongkawe Medical record Librarian Supaporn Ngamsangiam Medical record Librarian Kueakul Klangjaroenpanich Coder Panjamaporn Soisakun Coder Anothai Rinrucsa Coder Chaowanee Joongsai Coder Vili Pomma Coder Veena Vachirachaipaisan Coder Katewalee Tumsatant Coder Boppha Rattanasupphakuna Coder Surasak Wattanakoon Coder Vijitra Noppasit Cordinator

4. Banglamung Hospital 699 Moo 5 Naklua, Banglamung, Chonburi 20150 Tel. 0-3841-1551-2 Fax. 0-3842-8464

Prasit Jittiwattanapong, M.D. Director Seefah Wahachat, R.N. Nantanee Ratanakitsorn, R.N.

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

5 . Botong Hospital 300 Moo1 Bo thong, Bo thong, Chonburi 20270 Tel. 0-3821-1288, 0-3821-1290 Fax. 0-3821-1289

Wutichai Tawattongchai, M.D. Director Jiraporn Noybuangam Medical record Librarian

6. Banbung Hospital 3 Soi 19 Ban Bung, Ban Bung, Chonburi 20170 Fax. 0-3844-2299

Chumpol Pobsuk, M.D. Director Jatuporn Ayamung, R.N. Registed Nurse Pornpat Kaithananun Medical record Librarian

7. Panatnikhom Hospital 68 Moo 6 Kud-ngong, Panatnikhom, Chonburi 20140 Tel. 0-3846-1332-6

Prayut Meanna, M.D. Director Yenchit Panatisak Medical record Librarian Pongsak Meenoi Medical record Librarian

8. Ko–Sichang Hospital 59 Moo 1 Tatevavong, Ko-Sichang, Chonburi 20120 Tel. 0-3821-6100, 0-3821-6266 Fax. 0-3821-6275

Chunchuree Kongmeesuk Kaneko, M.D. Director Pariwat Promrat Ratchanee Watanaphadith

9. Sattahip Hospital 33/37 Plutaluang, Sattahip, Chonburi 20180 Tel. 0-3824-5107 Fax. 0-3824-5508

Ramase Ampaipis, M.D. Director Sumit Thummapimuk Dentist Prasit Yodma Medical statistics

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

10. Nong Yai Hospital 207 Moo1 Nong-Yai, Nong-Yai, Chonburi 21090 Tel. 0-3821-9310 Fax. 0-3821-9145

Vichai Tanasophol, M.D. Director Keeratipon Wiengpon Assistant Director Phayao Somya Janyaporn Boonsuwanno, R.N.

11. Ao–Udom Hospital 188/36 Moo 6 Tungsukhla, Sriracha, Chonburi 20230 Tel. 0-3835-1010-2 Fax. 0-3835-2393

Singchai Prodsathaporn, M.D. Director Piyanuch Sroysme Medical record Librarian

12. Watyansangwararam Hospital 33 Moo11 Banglamung, Chonburi 20260 Tel. 0-3823-8374-5 Fax. 0-3823-8374-5

Prasit Jittiwattanapong, M.D. Director Imchit Denfanapapol, R.N.

13. Panthong Hospital 1/10 Moo 8 Panthong, Panthong, Chonburi 20160

Sophon Wichianprapai Director Wantana Sakonsukon, R.N. Sriwipa Rungratsamee Medical record Librarian

14. Health Promoting Hospital 43 Moo7 Napa, Muang, Chonburi 20000 Tel. 0-3878-6974 Fax. 0-3879-9732

Chaipon Promsingh, M.D. Director Ampunpron Namsumya, R.N. Preeyapon Thongkum Medical Officer (Cytoscreener)

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

15. Health Science Center Burapha University 169/382 Sansuk, Muang, Chonburi 20131 Tel. 0-3839-0580 Fax. 0-3874-5803

Pisit Piriyapun, M.D. Director Wilairat Jatusuwonasri Medical record Librarian Kochawan Krongklang Medical record Librarian

16. Somdej pranangchao sirikit Hospital 163 Moo1 Sattahip, Chonburi 20180 Tel. 0-3824-5735 - 40 Fax. 0-3824-5939

Padermpong Rumakhom, MD Director Pramote Aunauychai Aumpansak Paunsom Chumporn Dumrongsupasoonton

17. Cancer Institute, Siriraj Hospital, University Hospital Bangkok Parnnok Rd. Bangkoknoi Bangkok 10700 Tel 0-2419-7000 Ext 4471-2,0-2412-1360 Fax 0-2412-9169

Asso. Prof. Viraiporn Posuwan, M.D. Chief of Cancer institute

18. Queen Savangvadhana Memorial Hospital 290 Sriracha, Sriracha, Chonburi 20110 Tel. 0-3832-2157 - 9 Fax. 0-3832-2157

Jaroong Ukapatsakul, M.D. Director Daovadee Naraporn, R.N. Wilai morpakham, R.N.

19. Fort Nawamintharachini Hospital Bansuan, Muang, Chonburi 20000 Tel. 0-3827-3034

Supatchai Mekasuwandit, M.D. DirectorSuparat Jintakasigum, P.N.

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

20. Abhakornkiartiwong Hospital 2045 Moo1 Sattahip, Sattahip, Chonburi 20180 Tel. 0-3843-7171 Fax. 0-3843-7171

Chumpol Thaimchi, RTN. Director Wichein Suttha, RTN. Medical Officer Jumlong Petchsook, R.N. Medical Officer

21. Bangkok Hospital Pattaya 301 Moo 6 Sukhumvit Rd., Banglamung, Chonburi 20150 Tel. 0-3842-7751-5 Fax. 0-3890-9093

Pichit Kangwolkij, M.D. Director Wachara Khaowphong Nurse head of department Sunisa Thongnam Head of department

22. Pattaya Memorial Hospital 328/1Central Pattaya Rd., Banglamung, Pattaya City, Chonburi 20150 Tel. 0-3842-9422-4 Fax. 0-3842-2740

Somkiat Thanapaisalpipat, M.D. Medical Director Nattakran Kumkong Medical Statistic

23. Samitivej Sriracha Hospital 8 Soi Laemket, Jermjompol Rd. Sriracha, Chonburi 20110 Tel. 0-3832-4100 Fax. 0-3832-4123

Somchai Pattana-Anek, M.D. Director Sabaitip Viruthpetch Cluster Manager

24. Cholvaej Hospital 104/15 Muang, Soi Wattonson Arkaniwat Rd., Chonburi 20000 Tel. 0-3828-4354, 0-3828-4355, 0-3828-4366

Amporn Tanabodee, M.D. Director Taweerach Vithee, R.N.

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

25. Phya Thai Sriracha Hospital 90 Srirachanakorn 3 Rd., Sriracha, Chonburi 20110 Tel. 0-3877-0200 Fax. 0-3877-0213

Thanakom Manthananon, M.D. Executive Director Chanchai Leesomprasong, M.D. Director Neeranuch Soontornvipartporn Assistant Manager Pornnicha Apichatvorapong Coder Nurse

26. Pattaya International Hospital 255/4 Soi 4 Pattaya 2nd Rd., Nongprue, Banglamung, Chonburi 20150 Tel. 0-3842-8374 Fax. 0-3842-2773

Sunya Viravaidya, M.D. Director Natticha Kodtharin, R.N. Khamkaew Eksomboon Head Medical Record

27. Aikchol Hospital 68/3 Prayasatja Rd. Chonburi 20000 Tel. 0-3893-9999,0-3827-3840 -7 Fax. 0-3827-3848, www.Aickchol.Com

Charan Chaipat, M.D. Director Srikallaya Mukkarom. Head Medical Record Kadmanee Songkit Medical Record

28. Aikchol Hospital 2 31/2 Angsila Rd., Muang, Chonburi 20000 Tel. 0-3893-9888 Fax. 0-3893-9800

Chailerd Kulkolkarn Director Surinthon Triapibanwongsa Head Medical Record Alisa Chinsawattana Medical Record

O Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

1.1. Overview (ICD-O), Third Edition (Fritz et al., 2000) World Health Organization Geneva. This monograph is published by Chonburi Cancer Center in collaboration 1.2. Background of population-based with Chonburi provincial hospital, Chonburi in Thailand Provincial Public Health Service, all private The first Thailand’s population based hospitals, all community hospitals, Military cancer registration was established in Chiang hospital and University hospital especially the Mai province in 1985. It began by building up pathological and hematological unit of a database on the incidence and mortality of Chonburi provincial hospital. cancer in Chiang Mai province since 1983 by retrospective data collection from 1983-1987 This publication is the second as a cancer research project which was report on population-based cancer supported by the China Medical Board and the registry in Chonburi province during the Faculty of Medicine, Chiang Mai University. period 2003-2007, five years period. The first report published in 1989 (Martin et al., 1989) and also included in “Cancer in Five The aim of this report is to present Continents” Vol. VI. (Parkin et al.,1992). the data on cancer incidence, mortality and In Thailand the first population-based trends in Chonburi province and the cancer registry started in Chiang Mai in 1985, incidence of cancer in 10 districts and 1 sub followed by registries in Khon Kaen in 1988, district. To provide comparable the incidence Songkhla in 1990, Bangkok in1990, Lampang rates of cancer from difference areas of in 1993, Lop Buri and Chonburi in 2003. Chonburi and of Thailand during the same In the year 1993 with cooperation of period and the previous period. the registries of Chiang Mai, Khon Kaen and The main purpose of the publication Songkhla, the National Cancer Institute and is to provide health professionals researchers the International Agency for Research on and policy-makers with detailed information Cancer (IARC), the first volume of “Cancer in regarding the incidence and geographic Thailand” 1988-1991 (Vatanasapt et al., 1993) distribution of all types of cancer by age, sex was published, followed by second volume in five years from 2003-2007. 1992-1994 (Deerasamee et al., 1999), the third 1995-1997 (Sriplung et al., 2003) and the forth We also present the comparisons 1998-2000 (Khuhaprema et al.,2007) which are of the result and data quality including shown in Table1.2. M/I ratio from volume I and after being The detailed result of cancer from updated for 2 years with the result and Chiang Mai and Khon Kaen were included in data quality in this study (2003-2007). “Cancer in Five Continents” volume VI and VII. The result of cancer from 5 registries It is hoped that these data will (1992-1997); Chiang Mai, Khon Kaen, stimulate decisions making and priority Songkhla, Bangkok and Lampang were setting processes at the individual, reported in volume VIII of “Cancer in five community, province and nation levels. continents” (Parkin et al., 1992, 1997 and 2002) Material in this publication may be used for (Table 1.1). Cancer registries in Thailand which genuine education and health research. The already be published, are shown in Figure 1.4. monograph is also be used by educators, the media and members of the public with an Five cancer registries consist of interest in cancer. In this monograph we Chiang Mai, Khon Kaen, Bangkok, present incidence rates according to cancer Songkhla and Lampang were the members sites classified by the International of International Association for Cancer Classification of Diseases for Oncology Registry (IACR) which provides links with cancer registries throughout the world. Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Chonburi Cancer Center, one of the 1.4. Population of Chonburi six regional cancer centers was established in 1994, under the supervision of the National The population census was carried out Cancer Institute for cancer prevention and every ten years. The total population at 2000 control in the eastern part of Thailand as a result census was 1 145 401 with 561 752 males and the population-based cancer registration in the 583 649 females about 33% of total population province has been set up. The National Cancer of the eastern part of Thailand (Table 1.3), Institute and all regional cancer centers have a 96.9% are Buddhism, 99.4% are Thai role in all main activities of cancer prevention nationality. About 54% lived in municipal area, and control, including prevention, screening and the rest (46%) in non municipal area (Population tertiary care as well as having clinical research and Housing Census 2000). The average activity. Chonburi Cancer Center has provided population density is about 247 persons per programs in patient and public education and in square kilometer. The highest population density continuing education for health professionals, was 1100 persons per square kilometer in particularly family physicians and general nurses Muang Chonburi district. The lowest population especially in the eastern part Thailand. This density was 54 persons per square kilometer in covered only 6 provinces: Chonburi, Rayong, Nong Yai (National Statistics: Chonburi 2000). Chanthaburi, Trat, Chachoengsao, Srakaeo The population density is show in the Figure which is shown in Figure 1.2. 1.3.

1.3. Geographic Situation of Chonburi: 1.5. Occupation

Chonburi is situated in the eastern part The most important occupations are of Thailand, between 12o-13o N and 100-102 o E, farming of rice, sugar beans, fishing and shrimp 80 kilometers from Bangkok by car or bus and farming. The Industrial Estate Authority of train, with land area 4363 square kilometers and Eastern part of Thailand is situated in this area is bounded in the north by Chachoengsao, in the especially in Chonburi, Rayong and east by Chanthaburi, in the south by Rayong and Chanthaburi. In Chonburi there are 2271 in the west by the bank of Gulf of Thailand factories, 410 in the Industrial Estate Authority (Figure 1.1). and 1861 out of the region, about 290 160 The central part of the province is workers. predominantly mountainous stretching from Nowadays, it is becoming appreciated north-west to south-east, about 200 meters for its tourism potential, especially Bang Saen, above the sea level. The climate is hot and dry Ko si chang, Pattaya, Jomtien beach with its the highest temperature about 42 o C in summer splendid beaches, crystal clear water, off-shore from March to May, in winter from November islands, aquatic marine life, and unspoiled vistas. to February, rainy season started from June to While inland, verdant forestlands and cascading October. The average total rainfall is 1342.2 waterfalls create a lush, tropical atmosphere. millimeters per year. 1.6. Medical Services and Health Status At the time of census, in April 2000, Chonburi was divided into 10 districts, 1 The total number of hospitals in subdistrict, 92 communes (Tambon), 692 Chonburi province was 26 hospitals composed villages and 26 municipal areas. The districts of of 12 community hospitals, 8 private hospitals Chonburi were: Muang Chonburi, Sri Racha, and 1 provincial hospital, 3 military hospitals Ban Bung, Nong Yai, Bang Lamung, Sattahip, and University Hospital providing 4745 total Phan Thong, Phanat Nikhom, Bo Thong, Ko beds. The medical personals composed of 274 Sichang and subdistrict Ko Chan. registered medical practitioners, 64 dentists, 89 pharmacists and 1621 nurses. The population to doctor ratio was 3799:1. 1 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Cancer diagnostic services including Figure 1.2 Eastern Thailand radiological diagnosis equipment such as: X-ray, ultrasound, computed radiography, mammogram, CT scan and pathological investigations are available in Chonburi provincial hospital, private hospitals and Chonburi cancer center. Cancer treatment, radiotherapy Srakaeo equipments: one simulator, cobalt-60 machine, Chachoengsao linear accelerator and remote after-loading devices for brachytherapy are available at the Chonburi cancer center. Cancer surgery and Chonburi cancer chemotherapy service are provided in Chonburi cancer center, provincial hospital and Rayong Chanthaburi private hospitals. Some of cancer patients go to Bangkok especially King Chulalongkorn Memorial University hospital which providing clinical consultations, radiological and Trat pathological investigations for cancer diagnosis including cancer surgery services, radiotherapy and chemotherapy for cancer treatment. All hospitals in the province provide palliative care.

Figure 1.1 Map of Chonburi, Thailand. Figure 1.3 Population densities by districts, Chonburi, Thailand. (census2000).

Chachoengsao Phan Thong Phanat Nikhom 270 262 Ko Chan Muang Chon buri 135 349 Chachoengsao 1100 Ban Bung Bo Thong 138 55 Ko Sichang Srakaeo Sri Racha 270 225 Nong Yai Chonburi 54

Chanthaburi Bang Lamung 447 205 Rayong Trat Rayong

Sattahip 364 127

Average population density = 247 per Square kilometer

2 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 1.1 Cancer in Five Continents (Thailand).

Volume VI 1983-1987 Male Female No. of cases ASR (world) No. of cases ASR (world)

Chiang Mai 3512 177.5 3727 168.1 1983-1987 Khon Kaen 1825 185.8 1596 153.1 1988-1989 Volume VII 1988-1992

Chiang Mai 4791 148.4 5006 155.6 1988-1992 Khon Kaen 4207 190.6 3384 132.4 1990-1993

Volume VIII 1993-1997

Bangkok 9449 144.3 10812 126.8 1995-1997 Chiang Mai 5177 145.5 5552 150.9 1993-1997 Khon Kaen 5784 179.2 4779 128.1 1993-1997 Lampang 3526 180.5 3261 154.6 1993-1997 Songkhla 1879 99.6 1785 82.8 1993-1997

Table 1.2 Cancer in Thailand

Volume I 1988-1991 Male Female No. of cases ASR (world) No. of cases ASR (world)

Bangkok 4825 97.4 5842 87.5 1988-1990 Chiang Mai 3656 208.3 3809 189.6 1988-1991 Khon Kaen 3971 196.9 3231 154.4 1988-1991 Songkhla 1122 110.9 972 81.6 1998-1991 estimate(1990) Thailand 29950 153.6 29517 128.5

3 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007 Table 1.2 Cancer in Thailand (continue)

Volume II 1992-1994 Male Female No. of cases ASR (world) No. of cases ASR (world)

Bangkok 7292 117.9 8283 100.5 1992-1994 Chiang Mai 3180 148.1 3308 156.4 1992-1994 Lampang 1834 168.3 1681 143.6 1992-1994 Khon Kaen 3172 173.8 2671 127.9 1992-1994 Songkhla 1353 99.0 1225 79.0 1992-1994 Thailand 32565 150.4 30710 123.0 Estimate(1993)

Volume III 1995-1997 Male Female No. of cases ASR (world) No. of cases ASR (world)

Bangkok 9447 143.6 10807 125.9 1995-1997 Chiang Mai 3029 142.5 3325 148.6 1995-1997 Chiang Mai 2884 125.8 3411 138.1 1998-2000 Lampang 2194 178.0 1991 146.1 1995-1997 Lampang 2045 157.5 2080 146.0 1998-2000 Khon Kaen 3661 182.5 2899 125.3 1995-1997 Khon Kaen 3673 172.6 3357 132.6 1998-2000 Songkhla 1355 91.6 1383 81.3 1995-1997 Songkhla 1637 102.6 1782 96.6 1998-2000 Thailand 35539 149.2 38467 125.0 Estimate(1996)

4 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 1.2 Cancer in Thailand (continue)

Volume IV 1998-2000 Male Female No. of cases ASR (world) No. of cases ASR (world)

Chiang Mai 3170 138.7 3760 152.5

Lampang 2042 160.7 2050 148.9

Nakhon Phanom 874 107.7 883 92.6

Udon Thani 3292 242.0 2815 158.4

Khon Kaen 3567 167.6 3281 129.7

Rayong 719 122.8 806 115.2

Bangkok 8466 117.4 10907 116.0

Prachuop Khiri 415 74.7 514 77.6 Khan

Songkhla 1667 104.5 1822 98.9

Thailand 94746 127.7 101034 125.5 Estimate(1999)

Other publications of cancer

Male Female ASR (world) No. of cases ASR (world) No. of cases

Bangkok** 15120 175.0 16941 158.8 Lampang Vol. II* 3492 160.8 3573 152.0 Lamphun Vol. I* 1542 130.3 1735 138.9 PhitsanulokVol.I * 1999 107.5 2002 89.4 Lopburi Vol. I* 2396 127.2 2592 120.0 Chonburi Vol. I* 2928 129.0 3187 120.0 After update 3245 143.0 3564 134.0 (Chonburi) Vol. I*

** Cancer incidence in Bangkok 1993 - 1997 * Cancer in Lampang, Lamphun, Phitsanulok and Lopburi 1998 - 2002

5 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 1.3 Population (2007) of the Eastern part of Thailand

Province No. Percentage

Chonburi 1,078,518 31.0

Rayong 523,518 15.0

Chanthaburi 493,434 14.1

Trat 223,924 6.4

Chachoengsao 639,751 18.3

Srakaeo 530,621 15.2

Total 3,489,766 100

Table 1.4 Increasing number of cases and percentage (1998-2002) after update

Vol. I After update Increasing Year

No. of cases No. of cases No. of cases Percentage

1998 (2541) 1026 1191 165 16.0

1999 (2542) 1235 1342 107 8.7

2000 (2543) 1182 1340 158 13.4

2001 (2544) 1311 1448 137 10.4

2002 (2545) 1361 1488 127 9.3

Total 6115 6809 694 11.3

6 Introduction

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 1.4 Population-based cancer registries in Thailand

7 Methods

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

2.1. Sources of Data form was checked and extended into data base files, using the CanReg4 program for All data on cancer patients were data entry and analysis. collected by mixture of passive and active The database is continually being methods involving notification by the staff of updated and quality of data improved Chonburi Cancer Center, Chonburi across the entire period of cancer provincial hospital, 8 Chonburi reporting, consequently a small change private hospitals, 12 community may be expected when this step complete hospitals under supervision of Chonburi and publication. Provincial Public Health Service, 1 University Hospital, 3 Military Hospitals, 1 laboratory, 2.3. Type of Diagnosis with some information from Chulalongkorn University and information of deaths from all Types of diagnosis have been divided causes of death from Bureau of Health Policy into two broad categories: histological and Strategy, Ministry of Public Health (http; confirm and no histological confirm. These // 203.157.19.191). are given below in approximate order of Registry receives information from increase validity. Chonburi Provincial Public Health Service on some cases of deaths from all causes. All No histological confirm; death certificates are matched with the 0. Cancer cases which diagnosed by incidence case records of the registry. Death certificate only Individual certified as having died of 1. Clinical only cancer are registered as “Death Certificate 2. Clinical investigation (including, X- Only (DCO)” cases if no other information ray, ultrasound, CT scan, etc) about the individual can be traced from the 3. Cases which diagnosed by surgery or other sources. autopsy without histology 4. Specific immunological and/or Bio- 2.2. Registry Methods chemical tests

New cancer cases were collected Histological confirm; from out and in patient departments, wards, 5. Cancer cytology or hematology radiotherapy unit, surgery unit, cytology unit, 6. Histology of metastasis sites hematology unit, medical record, pathological 7. Histology of primary tumor unit and autopsy service. The data 8. Autopsy with histological. information collected includes demographic details for each cancer patient that consists 2.4. Extension of Cancers of: registry number, name, residential Extension in cancer registration is used address, date of birth, age, sex, date of with the following items; diagnosis, site of cancer, histology of cancer, 1. In situ staging, extension of disease, method of 2. Localized diagnosis, treatment, date of last contact and 3. Direct extension status of cancer patients (alive or dead). 4. Regional nodes metastasis The primary site and histology were 5. Distant metastasis coded according to ICD-O third edition 8. Not applicable (Fritz et al, 2000). 9. Unknown Second primary cancer was also 2.5. Staging of Cancers registered a new registration number was given for each new primary cancer. Cases of Staging of cancers in this cancer carcinoma in situ were registered but not registration is used with the TNM included in the analyses. The computed data Classification of Malignant Tumors of

8 Methods

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

International Union against Cancer (UICC) had the age group for the whole province second edition (Spiessl et al., 1982). and including in districts. The population pyramid of Chonburi province is shown in 2.6. Date of Diagnosis Appendix A.

All cancer registries have some 2.9 Statistical Methods registrations from death certificate only (DCO). If it is not possible to ascertain a date Statistics from this report present of diagnosis prior to death then date of the data on cancer incidence in the diagnosis is deemed to be the same as the date province, in 10 districts and in 1 sub district of death and the case is classified as a DCO. of all malignancies for each cancer site and Similarly, when notification occurs only sex, numbers of registrations. The number from an autopsy report, the date of diagnosis is of new cancers, age-specific incidence rates the same as the date of death. and age-standardized incidence rates of five-year period by districts (1998-2002) and 2.7. Follow-up the population pyramid by districts are shown in Appendix B. Follow-up is very important for cancer registration. If it has a good follow-up, the analysis of cancer survival can be obtained. Definitions Follow-ups of cancer patients were performed Age in all cancer cases. The age of the patient (in complete A mixture of active and passive years) at the time of diagnosis or death methods was carried out. Registered cases were first matched with death certificates. For the Age groups remaining cases thought to be alive, follow-up information was obtained by repeated scrutiny The basis for most statistics is of hospital case records, postal enquires and if summation of cases by five-year age groups. these measures failed to establish a patient’s Age groups are expressed in whole years, vital status and home visits done by personals i.e. “5-9” means 5.0 to 9.99…. years. of the Public Health Service of Chonburi. The first task of registry was to match Incidence increasing notifications against the registration to see if the case had already been registered The number of new cases of a given from by other sources. Demographic details type of cancer diagnosed during the year. and codes for cancer site and histology were The basic unit of reporting is a new case of entered in the system and data was checked for cancer rather than an individual patient, internal consistency and completeness. Further expressed as a rate per 100 000 persons in notifications for cancer already on the system the population. were also processed, with differences being Incidence is the number of new resolved by follow-ups, and censoring data for cancer cases in a defined population within survival analysis which could not be perform a specific period of time. in this publication.

2.8. Population dominators Population at risk The population at risk is a part of The population dominators used for population which is susceptible, to have the calculation of average incidence rates was a specific cancer. It is defined on the taken from the population census of 2000. basis of demographic data. Statistical Reports of province which already

9 Methods

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Calculation of Rates Age-standardized Incidence Rates (ASR) Rates Age-standardized incidence rate is a summary measure of a rate that a Rates in this report are calculated population will have if it has a standard age separately for males and females and expressed structure. It is calculated first by estimating as cases per 100 000 person-years. If one year’s the age-specific incidence rates and then data are being analyzed, this is equivalent to n applying these rates to the standard cases per 100 000 population for that year. population. The most frequently used standard population is the world standard Total Number of Cases (C) population; the calculated incidence rate is then called the world-standardized The total number of cases, calculated incidence rate. It is also expressed per 100 as the sum of cases in all age groups. 000 population. Standardization is necessary when comparing several populations that Crude Incidence Rates differ with respect to age because age has powerful influence on the risk of cancer. So Crude rates are the number of new they are suitable as a basis for comparison cases during the year, expressed as a rate per of the rates in different areas. 100 000 persons in the population. Crude Incidence rates are calculated Age-standardized Mortality Rates simply as the total new cancer cases divided by (ASMR) the total population over a wide age range, multiplied by 100 000 to give a rate per 100 The age-standardized mortality 000. They are not suitable as a basis for rates (ASMR) are calculated in the same comparison of the rates in different areas if the way as age-standardized incidence rates age-structures of the populations differ. but change the cases from new cancer cases to dead cases in each year. The Age-specific Rates dead cases were adjusted age by using the age at death so called “Age-adjusted Age-specific rates are the number of mortality rate or Age-standardized new cases of cancer or cancer deaths during mortality rate (ASRM)”using CanReg4 the year, expressed as a rate per 100 000 persons in the population. program after the computed data from Age-specific rate is the incidence and is check and extended into the data base mortality rate in a specific age group. So age- files. specific rates are calculated by dividing the number of cancer cases in each five years age 2.10 Data Quality Control group and sex structure of Chonburi population in that age group and multiplied by Quality control was carried out 100 000. The rates are usually expressed per though the following indices: 100 000 of population.

AR = Ni/Pi x 100 000 Ni = Number of new cancer occurring in the ith age group th Pi = Population of the i age group in Chonburi province.

10 Methods

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

2.10.1 Histologically Verified Percentage (%HV): The percentage of cases diagnosed 2.10.3 The Mortality Incidence Ratio: was based on histology examination of tissue (M/I) from primary site or from metastasis site, bone marrow, cytology and peripheral blood M/I ratio is the number of deaths in for leukemia. A low proportion of a given time period divided by the number of histological verification suggests over incidence cases for that time period reporting or it is very difficult to get a tissue expressed as a percentage. diagnosis. A hundred percent of histological If the number of death in a period verification suggests under reporting. Clinical exceeds the number of incidence cases, the cases were not included unless they were Mortality and Incidence ratio expressed as easily to get tissue diagnosis. percentage may be in excess of 100%. As a result, the cancer registration is considered 2.10.2 Death Certificate Only (DCO) incomplete, under reporting or may be Percentage: occurring of course for rarer cancer cases or the incidence was declining very rapidly. If The percentage of cases where registration is complete and the incidence of diagnosis was based on information obtained cancer is not changing rapidly, the mortality from a death certificate. When a death to incidence ratio should reflect long-term certificate is received containing information survival. If survival rates are comparable in on a tumor or patient not previously known populations, a more complete case to the registry, the records are checked to ascertainment is suggest by a lower M/I ratio. confirm the disease and date of diagnosis. All A high level of mortality incidence ratio or death certificates mentioned cancer deaths, closed to 100% is regarded a very difficult to are reviewed and matched against the treat or to diagnose of that cancer, poor registered cases in our files. The cases which prognosis cancer such as liver cancer, lung could not matching records were found and cancer, pancreatic cancer and cancer of gall were traced back to the relevant data. Those bladder with short-term or low the survival could not be traced back to an existing entry rates. A low proportion of M/I ratio is in the registered cases would be labeled as a regarded as a good result of treatment or ‘Dead Certificate Only’ and the date of death easily to diagnose with long-term survival, would be taken as the date of diagnosis. good prognosis such as skin cancer, breast The proportion of DCO registration cancer and cervical cancer. is widely used as an indicator of ascertainment and data quality, if this The rapid increase in percentage is high, it reflects the degree of incident rates reflected improved under reporting in the registry and is missing registration of new cancer cases due to cancers as they are diagnosed. A low level of increasing consistency of cancer from all DCO (less than 5%) is regarded as an collaborators in Chonburi. indicator of good data quality, a high degree of completeness. A very low or zero level of DCO cases may indicate that the registry is not receiving information on all deaths.

11 Methods

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 2.1 Source of information and the registration process

Pathological lab Death Certificate

All hospitals in and King Chonburi Chulalonkorn

Memorial hospital

Check with registered cases

Registered Non Cases registered Cancer Registry Update date cases Check Coding of death topography

Morphology Staging and treatment

Trace back to the hospital

Known Not known Computer Hospital Hospital file

Analysis

Registered as a Register if it Delete if not death be cancer mention Certificate Publish case cancer Only (DCO)

12 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

3. RESULTS OF ALL CANCERS

Incidence males and from 7.7 to 4.2 among females. This reflected improved of data registration. There were 9 128 incident cases of new cancer in Chonburi residents, during Figure 3.1 Leading cancers of new cases the period of 2003-2007, 4298 among males and 4 830 among females, with sex ratio of Male new cancer cases in males and females approximately 1:1.1. The average age- Lung 37.9 standardized incidence rate was 166 per 100 Liver 20.9 Colorectal 15.9 000 population among males and 150.0 Prostate 8.8 among females (Table 3.1). Oral Cavity 8.5 Skin 8.4 Leukemia 6.5 After update of cancer during 1998-2002 SiteCancer Lymphoma 6.2 Esophagus 6.1 Increasing about 11% (694 cases) of Bladder 6.1 new cancers during 1998-2002 after update from the first report (Caner in Chonburi 0 10 20 30 40 Vol.I, the rate was changed from 129 per 100 000 population to 143 per 100 000 ASR population among males and from 120 to 134.0 among females with improvement of data quality, increasing of Histological Female

Verified from 57% to 64%, decreasing of Breast 31.5 percentage of DCO from 18.2% to 13.3% Cervix 25.8 and M/I ratio from 60% from to 66% Lung 14.5 (Table 3.2). Colorectal 11.2 Ovary 6.2 Among males in Chonburi (2003- Liver 5.9

2007), lung cancer was the most common cancer Cancer Site Skin 5.5 (935 cases, ASR =37.9 per 100 000 Thyroid 5.5 population), followed by liver cancer (558 Leukemia 5.4 cases, ASR=20.9) and colorectal cancer Corpus 5.1 (418 cases, ASR=15.9) the same as in Lymphoma 5.1 previous period in Chonburi (Thepsuwan et 0 5 10 15 20 25 30 35 40 al., 2007), Lampang, Lamphun and ASR Phitsanulok (1998-2002) (Pongnikorn et al., Age-specific incidence and mortality 2004 and 2006), Chiang Mai(1998-2000) rates (Figure 3.2) (Sumitsawan et al., 2003) and an Bangkok (1998-2000) (Khunhapremaet et al., 2007). Age-specific incidence rates, For females in Chonburi(2003-2007), 5-year groups are plotted using data for breast cancer was the most common cancer (1078 cancer incidence during the period 2003- cases, ASR=31.5) followed by cervical 2007.The incidence rates were higher cancer (866 cases, ASR=25.8) the same as among females than males during the age of females in Bangkok(1993-1997) (Martin et 30-60 years, for all other age group al., 2001) and lung cancer was the third (432 incidence rates were higher among males cases, ASR=14.5) (Figure3.1). than females. The adjusted mortality rates In this study, the age-standardized in males are higher than females in all age incidence rate of unknown primary sites group. Due to high incidence rates of were lower than the previous period, from cervix and breast cancer 11.7 to 6.4 per 100 000 population among 13 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007 than females in all age group. Due to high incidence rates of cervix and breast cancer among females in the younger age group oral cavity, colorectal liver and prostate for and lung and prostate cancer occurring in males and cervix for females. the older age among males. Cancer Extension (Figure 3.4) Figure 3.2 Age-specific incidence and mortality rates of all cancers The percentage of cancer extension 1600 at the time of diagnosis in this study, 1400 000

, increasing of localized cancer, regional 1200 100 1000 metastasis and distant metastasis from 800 previous reported ( for localized 4.4% to 600 400 15.4%) in both males and females, (2.7%to Incidenceper 200 0 12%) among males and (6.0% to 22%) 4 9 + 0- 5- -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 among females while decreasing of Age Group unknown stage of cancers (72.8% to 45% for both sexes, 76% to 49% for males and Cancer by IncidenceAge MaleGroups (FigureIncidence Female 3.3) Mortality Male Mortality Female 69.8% to 35% for females), reflected of The relative contribution of improvement of data quality. different types of cancer varied considerably according to the age group in this study. Data Quality Control of All Cancers Leukemia was the main cancers that contribute to the disease burden in children In this study, data quality of cancer (age 0-14) in both boys and girls in was better than the previous report due to Chonburi during 2003-2007 followed by increasing of histological verified from lymphoma among boys; brain and 57.4% to 74% for both sexes, 51% to 68% lymphoma among girls. and 63.4% to 80% for males and females For adolescents and young adult respectively and decreasing of the (age 15-24 years), leukemia still was the percentage of death certificate only from most common among males followed by 18.2% to 4.8% for both sexes, 23.0% to lymphoma, brain, thyroid and testis cancer 6.6% and 13.7% to 3.3% for males and while thyroid cancer was the most common females respectively ( Table 3.4,3.5 and 3.6). cancer among girls followed by ovary, We also present M/I ratio breast cancer, leukemia and lymphoma. of cancer in Chonburi females (56%) had For middle-age 25-59, lung cancer better prognosis than males (73%) due to was the most common cancer among males the level of M/I ratio of cancer in females followed by liver, colorectal, oral cavity lower than in males (Table 3.3) cancer and lymphoma while cancer of breast was the most common cancer among Geographic Distribution of Cancers in females followed by cervix and, lung. Chonburi (Figure 3.5) For elderly (age 60-74), cancer of lung was the most common cancer among The highest incidence rates of all males followed by liver , colorectal, oral cancer was found in Bang Lamung (ASR cavity and prostate while breast cancer was =245 per 100 000 population) in males and the most common cancer among females 190 in females the same as in the previous followed by cervix. report while the lowest incidence rates was For elderly over 75 years, lung found in Bo Thong both males (ASR=136) cancer was the most common cancer and females (ASR=104.2)(Figure 3.5) among both males and females followed by

14 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007 Table 3.1 Number of new cancer cases and ASR

No. of new cancer ASR Year Total Male Female Male Female 1998 – 2002 6115 2928 3187 129 120 Vol. I 1998 - 2002 After 6809 3245 3564 143.0 134.0 update 2003 - 2007 9128 4298 4830 166.0 150.5

Table 3.2 Comparisons of data quality

NO. of NO. of NO. NO. M/I Year New Cancer of % of % % Cancer Death HV DCO

60 1998-2002 Both sexes 6115 3673 3512 57.4 1111 18.2

(Vol.I) Male 2928 2053 1495 51 674 23 70

Female 3187 1616 2019 63.4 437 13.7 50 1998-2002 Both sexes 6809 4461 4375 64 904 13.3 66 After update Male 3245 2434 1884 58 564 17.4 75

Female 3564 2027 2491 70 340 9.5 57

2003-2007 Both sexes 9128 5844 6769 74.2 441 4.8 64

Male 4298 3138 2910 67.7 282 6.6 73

Female 4830 2706 3859 79.9 159 3.3 56

15 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3.3 Leading cancers by age and sexes

0-14 Year Male 0-14 Female Leukemia 56 Leukemia 44 Lymphoma 21 Brain 14 Brain 13 Lymphoma 13 testis 8 Ovary 6 Bone 6 Soft Tissue 5 0 10 20 30 40 50 60 0 10 20 30 40 50 No.of case No.of case

15-24 Female 15-24 Year Male Thiyroid 43 Leukemia 19 21 Lymphoma 16 Ovary 19 Brain 10 Breast

Thiyroid 9 Leukemia 18 8 18 testis Lymphoma

0 5 10 15 20 0 10 20 30 40 50 No.of case No.of case

25-59 year Male 25-59 Year Female 910 Lung 451 Breast 679 Liver 379 Cervix Colorectal 247 Lung 207

Orel Cauity 136 Colorectal 179

Lymphoma 108 Thiyroid 119

0 100 200 300 400 500 0 200 400 600 800 1000 No.of case No.of case 60-74 Year Male 60-74 Year Female 402 Lung Lung 179 154 Orel Cauity Cervix 129 Colorectal 149 Colorectal 129 Liver 131 Breast 125

Prostate 123 Liver 68

0 100 200 300 400 500 0 50 100 150 200 No.of case No.of case Over 75 Year Male Ov er 75 Year Female

Lung 76 Lung 42 Prostate 44 Colorectal 34 Liver 37 34 skin 29 Colorectal Breast 23 18 bladder Cervix 22

0 10 20 30 40 50 60 70 80 0 10 20 30 40 50

No.of case No.of case

16 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3.4 Extension of all cancers by sexes.

Total

Localized Unknown 15.4% 44.5%

Direct extension 4.6%

Regional lymph node Not applicable 10.9% 1.1% Distant metastasis 20.7%

Male

Localized Direct extension 12% 2%

Regional lymph node Unknown 11% 49%

Distant metastasis 25%

Not applicable 1%

Female

Unknown Localized 35% 22%

Direct extension Not applicable 7% 1%

Distant metastasis 18% Regional lymph node 17%

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3.5 Geographic distributions by districts and sexes of all cancers

Male Female

173.7 Muang 170.7 150.5 Ban Bung 141.5 150.9 Nong Yai 142.3 245.0 Bang La Mung 190.7 154.0 Phan Thong 124.8 150.5 Phanat Nikhom 113.9 129.6 129.4 Sri Racha 122.0 238.1 Ko Si Chang 167.0 161.5 Sattahip Bo Thong 104.2 136.6 132.6 147.8 Ko Chan 0 50 100 150 200 250 300 300 200 100 0

Figure 3.6 Comparisons of ASR of all cancers to the others

Male Female

165.5 Chonburi (2003-2007) 150.4 142.9 Chonburi (1998-2002) 134.1 127.2 Lopburi (1998-2002)** 120 107.5 Phistsanulok (1998-2002)** 89.4 160.8 Lampang (1998-2002)** 150.8 130.3 Lamphun (1998-2002)** 148.6 138.7 Chiang Mai (1998-2000)* 138.9 122.8 Rayong (1998-2000)* 150.8 117.4 Bangkok (1998-2000)* 89.4 104.5 Songkhla (1998-2000)* 98.9 74.7 Prachuap Khiri Khan (1998-2000)* 77.6 167.6 Khon Kaen (1998-2000)* 125.3 242.0 Udon Thani (1998-2000)* 157.8 Nakhon Phanom (1998-2000)* 81.3 107.7 300 250 200 150 100 50 0 0 50 100 150 200 250 300

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Mortality Leading Cancer Deaths (Figure 3.7)

There were 5 844 cases of cancer During 2003-2007, registration of death in Chonburi residents, during the the three most common forms of cancer period of 2003-2007, 3 638 among males death, lung cancer was the most common and 2 706 among females, with sex ratio cause of cancer death (761 cases, ASR of cancer death in males and females =30.8 per 100 000 population), followed approximately 1.3:1. by liver cancer (502 cases, ASR=18.8 and The age standardized mortality colorectal cancer (261 cases, ASR=18.8) rates were 121.6 per 100 000 population in Chonburi, the same as the previous among males and 86.5 among females period (1998-2002). (Appendix A, Table 19-22). For females in Chonburi, cancer of cervix was the most common cause of cancer death followed by breast, lung, colorectal cancer and liver cancer.

Figure 3.7 Leading cancer deaths, 2003-2007

Male Female

Lung 30.8 Cervix 15.1

Liver 18.8 Breast 13 Colorectal 10.2 Lung 10.9 Cancer Site Oral Cavity 6.6 CancerColorectal Site 6

Esophagus 5.6 Liver 5.3

0 10 20 30 40 0 10 20 30 40

ASR ASR

Figure 3.8 Trends of incidence and mortality rates of all cancers, (1998-2007)

200

180

160

140

120

100 ASR 80

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3.9 Trend of incidence rates of leading cancers, (Male)

000 , 25 100 20

Incidence per

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

lung liver colorectal prostate lymphoma

Figure 3.10 Trend of incidence rates of leading cancers, (Female)

000 , 25

100 20

15 Incidence per

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

breast cervix lung colorectal thyroid

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007 Table 3.3 Percentage of mortality and incidence ratios by sexes and sites, Chonburi, 2003-2007 Male Female Total CANCER/SITES New Death M/I New Death M/I New Death M/I Lip 13 10 76.9 32 27 84.4 45 37 82.2 Tongue 105 83 79.0 32 19 59.4 137 102 74.5 Mouth 84 67 79.8 60 49 81.7 144 116 80.6 Salivary glands 22 10 45.5 21 10 47.6 43 20 46.5 Tonsil 29 25 86.2 4 3 75.0 33 28 84.8 Other Oropharynx 8 6 75.0 2 0 0.0 10 6 60.0 Nasopharynx 128 94 73.4 57 25 43.9 185 119 64.3 Hypopharynx 43 41 95.3 8 5 62.5 51 46 90.2 Pharynx unspec. 6 4 66.7 0 0 0.0 6 4 66.7 Oesophagus 151 137 90.7 37 33 89.2 188 170 90.4 Stomach 111 92 82.9 106 82 77.4 217 174 80.2 Small intestine 6 1 16.7 2 3 150.0 8 4 50.0 Colon 261 154 59.0 234 119 50.9 495 273 55.2 Rectum 154 103 66.9 109 62 56.9 263 165 62.7 Anus 3 4 133.3 4 3 75.0 7 7 100.0 Liver 558 502 90.0 183 165 90.2 741 667 90.0 Gallbladder etc. 67 55 82.1 55 41 74.5 122 96 78.7 Pancreas 62 57 91.9 76 66 86.8 138 123 89.1 Nose, sinuses etc. 25 13 52.0 17 10 58.8 42 23 54.8 Larynx 116 80 69.0 14 12 85.7 130 92 70.8 Trachea,Bronchus,Lung 935 761 81.4 432 324 75.0 1367 1085 79.4 Other Thoracic organs 6 1 16.7 5 3 60.0 11 4 36.4 Bone 16 13 81.3 14 9 64.3 30 22 73.3 Melanoma of Skin 19 13 68.4 15 10 66.7 34 23 67.6 Other Skin 189 42 22.2 151 32 21.2 340 74 21.8 Mesothelioma 2 2 100.0 0 0 0.0 2 2 100.0 Kaposi sarcoma 4 1 25.0 1 0 0.0 5 1 20.0 Connective,Soft tissue 40 27 67.5 35 21 60.0 75 48 64.0 Breast 7 3 42.9 1078 428 39.7 1085 431 39.7 Vulva 0 0 0 15 6 40.0 15 6 40.0 Vagina 0 0 0 6 4 66.7 6 4 66.7 Cervix Uteri 0 0 0 866 487 56.2 866 487 56.2 Corpus Uteri 0 0 0 159 68 42.8 159 68 42.8 Ovary 0 0 0 202 109 54.0 202 109 54.0 Other Female Genital 0 0 0 2 2 100.0 2 2 100.0 Placenta 0 0 0 14 2 14 14 2 14 Penis 31 22 71.0 0 0 0 31 22 71.0 Prostate 212 108 50.9 0 0 0 212 108 50.9 Testis 38 16 42.1 0 0 0 38 16 42.1 Other male genital 0 1 0.0 0 0 0 0 1 0.0 Kidney 24 14 58.3 15 10 66.7 39 24 61.5 Renal Pelvis 5 4 80 6 5 83.3 11 9 81.8 Ureter 1 1 100 4 2 50.0 5 3 60.0 Bladder 153 102 66.7 30 25 83.3 183 127 69.4 Other Urinary organs 1 1 100.0 1 1 100.0 2 2 100.0 Eye 8 3 37.5 7 4 57.1 15 7 46.7 Brain, Nervous system 75 54 72.0 60 50 83.3 135 104 77.0 Thyroid 37 17 45.9 186 45 24.2 223 62 27.8 Adrenal gland 2 0 0.0 3 1 33.3 5 1 20.0 Other Endocrine 1 0 0 2 1 50.0 3 1 33.3 Hodgkin disease 14 7 50.0 10 4 40.0 24 11 45.8 Non-Hodgkin lymphoma 164 112 68.3 141 80 56.7 305 192 63.0 Multiple Myeloma 18 11 61.1 28 22 78.6 46 33 71.7 Lymphoid Leukaemia 56 26 46.4 43 22 51.2 99 48 48.5 Myeloid Leukaemia 81 54 66.7 63 41 65.1 144 95 66.0 Leukaemia unspec. 30 20 66.7 47 37 78.7 77 57 74.0 Other & unspecified 177 164 92.7 136 117 86.0 313 281 89.8 All sites Total 4298 3138 73.0 4830 2706 56.0 9128 5844 64.0

21 Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 3.4 Data quality : Percentage of histological verified and death certificate only (Total), Chonburi, 2003-2007 CANCER/SITES cases Histo. %HV death certificate %DCO Lip 45 35 77.8 5 11.1 Tongue 137 126 92.0 1 0.7 Mouth 144 134 93.1 4 2.8 Salivary glands 43 36 83.7 2 4.7 Tonsil 33 30 90.9 0 0 Other Oropharynx 10 9 90.0 0 0.0 Nasopharynx 185 167 90.3 1 0.5 Hypopharynx 51 49 96.1 0 0 Pharynx unspec. 43 36 83.7 0 0 Oesophagus 188 142 75.5 5 2.7 Stomach 217 161 74.2 12 5.5 Small intestine 8 8 100.0 0 0.0 Colon 495 386 78.0 14 2.8 Rectum 263 241 91.6 0 0 Anus 7 7 100.0 0 0 Liver 741 171 23.1 98 13.2 Gallbladder etc. 122 56 45.9 12 9.8 Pancreas 138 48 34.8 17 12.3 Nose, sinuses etc. 42 39 92.9 0 0.0 Larynx 130 116 89.2 2 1.5 Trachea,Bronchus,Lung 1367 805 58.9 72 5.3 Other Thoracic organs 11 9 81.8 0 0.0 Bone 30 16 53.3 3 10.0 Melanoma of Skin 34 34 100.0 0 0 Other Skin 340 333 97.9 1 0.3 Mesothelioma 2 2 100.0 0 0.0 Kaposi sarcoma 5 5 100.0 0 0.0 Connective Soft tissue 75 75 100.0 0 0.0 Breast 1085 977 90.0 13 1 Vulva 15 14 93.3 0 0 Vagina 6 5 83.3 1 17 Cervix Uteri 866 745 86.0 6 0.7 Corpus Uteri 159 148 93.1 1 0.6 Ovary 202 159 78.7 6 3.0 Other Female Genital 2 2 100.0 0 0.0 Placenta 14 14 100.0 0 0 Penis 31 24 77.4 0 0 Prostate 212 150 70.8 10 4.7 Testis 38 37 97.4 0 0 Kidney 39 29 74.4 2 5.1 Renal Pelvis 11 9 81.8 0 0 Ureter 5 5 100.0 0 0 Bladder 183 145 79.2 2 1.1 Other Urinary organs 2 1 50.0 1 50.0 Eye 15 14 93.3 0 0.0 Brain, Nervous system 135 71 52.6 20 14.8 Thyroid 223 201 90.1 2 0.9 Adrenal gland 5 5 100.0 2 40.0 Other Endocrine 2 2 100.0 0 0 Hodgkin disease 24 24 100.0 0 0 Non-Hodgkin lymphoma 305 305 100.0 0 0.0 Multiple Myeloma 46 46 100.0 0 0 Lymphoid Leukaemia 99 99 100.0 0 0.0 Myeloid Leukaemia 144 144 100.0 0 0 Leukaemia unspec. 77 77 100.0 0 0.0 Other & unspecified 313 70 22.4 129 41.2 All sites Total 9128 6769 74.2 441 4.8 22

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 3.5 Data quality : Percentage of histological verified and death certificate only (Male), Chonburi, 2003-2007

CANCER/SITES cases Histo. %HV death certificate %DCO Lip 13 8 61.5 4 30.8 Tongue 105 95 90.5 1 1.0 Mouth 84 78 92.9 2 2.4 Salivary glands 22 17 77.3 1 5 Tonsil 29 26 89.7 0 0 Other Oropharynx 8 7 87.5 0 0 Nasopharynx 128 112 87.5 0 0 Hypopharynx 43 41 95.3 0 0 Pharynx unspec. 6 6 100.0 0 0 Oesophagus 151 119 78.8 3 2.0 Stomach 111 90 81.1 3 2.7 Small intestine 6 6 100.0 0 0.0 Colon 261 201 77.0 13 5.0 Rectum 154 138 89.6 0 0 Anus 3 3 100.0 0 0 Liver 558 128 22.9 76 13.6 Gallbladder etc. 67 29 43.3 4 6.0 Pancreas 62 21 33.9 12 19.4 Nose, sinuses etc. 25 23 92.0 0 0.0 Larynx 116 105 90.5 2 1.7 Trachea,Bronchus,Lung 935 547 58.5 54 5.8 Other Thoracic organs 6 6 100.0 0 0.0 Bone 16 9 56.3 2 12.5 Melanoma of Skin 19 19 100.0 0 0 Other Skin 189 185 97.9 1 0.5 Mesothelioma 2 2 100.0 0 0 Kaposi sarcoma 4 4 100.0 0 0 Connective Soft tissue 40 40 100.0 0 0 Breast 7 5 71.4 0 0 Penis 31 24 77.4 0 0 Prostate 212 150 70.8 10 4.7 Testis 38 37 97.4 0 0.0 Kidney 24 18 75.0 2 8.3 Renal Pelvis 5 4 80.0 0 0 Ureter 1 1 100.0 0 0 Bladder 153 121 79.1 2 1.3 Other Urinary organs 1 0 0.0 1 100.0 Eye 8 8 100.0 0 0.0 Brain, Nervous system 75 40 53.3 13 17.3 Thyroid 37 31 83.8 0 0.0 Adrenal gland 2 2 100.0 0 0 Oter Endocrine 1 1 100.0 0 0 Hodgkin disease 14 14 100.0 0 0 Non-Hodgkin lymphoma 164 164 100.0 0 0 Multiple Myeloma 18 18 100.0 0 0 Lymphoid Leukaemia 56 56 100.0 0 0 Myeloid Leukaemia 81 81 100.0 0 0 Leukaemia unspec. 30 30 100.0 0 0 Other & unspecified 177 40 22.6 76 42.9

All sites Total 4298 2910 67.7 282 6.6 23

Results

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 3.6 Data quality : Percentage of histological verified and death certificate only (Female), Chonburi, 2003-2007

CANCER/SITES cases Histo. %HV death certificate %DCO Lip 32 27 84.4 1 3.1 Tongue 32 31 96.9 0 0 Mouth 60 56 93.3 2 3.3 Salivary glands 21 19 90.5 1 4.8 Tonsil 4 4 100.0 0 0 Other Oropharynx 2 2 100 0 0.0 Nasopharynx 57 55 96.5 1 2 Hypopharynx 8 8 100.0 0 0 Oesophagus 37 23 62.2 2 5.4 Stomach 106 71 67.0 9 8.5 Small intestine 2 2 100.0 0 0 Colon 234 185 79.1 1 0.4 Rectum 109 103 94.5 0 0 Anus 4 4 100.0 0 0 Liver 183 43 23.5 22 12.0 Gallbladder etc. 55 27 49.1 7 12.7 Pancreas 76 27 35.5 5 6.6 Nose, sinuses etc. 17 16 94.1 0 0.0 Larynx 14 11 78.6 0 0 Trachea,Bronchus,Lung 432 258 59.7 18 4.2 Other Thoracic organs 5 3 60.0 0 0 Bone 14 7 50.0 1 7.1 Melanoma of Skin 15 15 100.0 0 0 Other Skin 151 148 98.0 0 0 Kaposi sarcoma 1 1 100.0 0 0 Connective Soft tissue 35 35 100.0 0 0 Breast 1078 972 90.2 13 1.2 Vulva 15 14 93.3 0 0 Vagina 6 5 83.3 1 17 Cervix Uteri 866 745 86.0 6 0.7 Corpus Uteri 159 148 93.1 1 0.6 Ovary 202 159 78.7 6 3.0 Other Female Genital 2 2 100.0 0 0 Placenta 14 14 100.0 0 0 Kidney 15 11 73.3 0 0 Renal Pelvis 6 5 83.3 0 0 Ureter 4 4 100.0 0 0 Bladder 30 24 80.0 0 0 Other Urinary organs 1 1 100.0 0 0 Eye 7 6 85.7 0 0 Brain, Nervous system 60 31 51.7 7 11.7 Thyroid 186 170 91.4 2 1.1 Adrenal gland 3 3 100.0 0 0 Other Endocrine 2 2 100.0 0 0 Hodgkin disease 10 10 100.0 0 0 Non-Hodgkin lymphoma 141 141 100.0 0 0 Multiple Myeloma 28 28 100.0 0 0 Lymphoid Leukaemia 43 43 100.0 0 0 Myeloid Leukaemia 63 63 100.0 0 0 Leukaemia unspec. 47 47 100.0 0 0 Other & unspecified 136 30 22.1 53 39.0

All sites Total 4830 3859 79.9 159 3.3

Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of oral cavity cancer affected more than females. Sex ratio male to female was 1.5:1 (Appendix A, Table 1-4). Oral cancer can be detected by visual inspection of the oral cavity by train health Mortality workers and doctors for reduction in incidence and mortality from oral cancer resulting by early The total number of oral cancer deaths detection of cancer. was 274 cases, 169 among males and 105 cases In Chonburi during the period 2003- among females, accounting about 5.3% of all 2007, oral cavity cancer was the fifth common cancer deaths in males and 3.9 % of all cancers leading cancer after cancer of lung, liver, in females. The age-standardized mortality rates colorectal and prostate and the fourth common were 6.6 per 100 000 population in males and cause of deaths from cancer in males after lung, 3.2 in females (Appendix A, Table 19-22). liver and colorectal cancer while it was not included in the ten leading cancer and the tenth Data Quality leading cause of cancer deaths in females. Over this period, the total number of The quality was good, with high level of oral cancer was 369 cases, 224 cases in males histological verified 88.4% for males and 91.7% and 145 cases in females, accounting about for females and low level of death certificate 5.2% of all cancers in males and 3.0% of all only (DCO) was 2.8% among males and 3.6% cancers in females. among females. The prognosis of oral cancer The average age-standardized incidence was rather fair with high level of mortality and rates were 8.5 per 100 000 among males and 4.6 incidence ratio. The M/I ratio was 75% among per 100 000 females (Table 4.1). Males are males and 72.0% among females (Table 4.1).

Table 4.1 Data quality of oral cavity cancer, 2003-2007

Male Female Number Rates Number Rates New cancer 224 8.5 145 4.6 Cancer death 169 6.6 105 3.2 Data quality Percentage Percentage Histology proof 88.4 91.7 Death Certificate Only 2.8 3.6 M/I Ratio 75 72

Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 4.1 Age-specific incidence and mortality rates of oral cavity cancer

60 000 , 50 100

30 Incidence per Incidence 20

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 4.2 Geographic distribution by districts and sexes of oral cavity cancer

Male Female

7.3 Muang 3.4 4.4 Ban Bung 5.6 15.2 Nong Yai 9.8 13.1 Bang La Mung 7.7 10.4 Phan Thong 4.5 10.8 Phanat Nikhom 3.9 9.3 Sri Racha 2.8 6.8 Ko Si Chang 0.0 5.6 Sattahip 5.8 3.7 Bo Thong 3.6 5.2 Ko Chan 6.0 20 15 10 5 0 0 5 10 15 20

Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 4.3 Comparisons of oral cavity cancer to the others

Male Female

8.5 Chonburi (2003-2007) 4.6 7.2 Chonburi (1998-2002) 4.4 3 Lopburi (1998-2002)** 3.3 2.1 Phistsanulok (1998-2002)** 2.3 1.6 Lampang (1998-2002)** 1.7 1.1 Lamphun (1998-2002)** 1.0 5.5 Chiang Mai (1998-2000)* 3.9 9.3 Rayong (1998-2000)* 4.9 4.9 Bangkok (1998-2000)* 3.3 2.8 9.7 Songkhla (1998-2000)* 4.4 5.7 Prachuap Khiri Khan (1998-2000)* 6.7 3.5 Khon Kaen (1998-2000)* 3.9 2.8 Udon Thani (1998-2000)* 4.9 1.3 Nakhon Phanom (1998-2000)* 0 2 4 6 8 10 10 8 6 4 2 0

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 4.4 Trends of incidence and mortality of oral cavity cancer (1998-2007)

6 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

25 Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Cancer of the colon and rectum average age-standardized incidence rates were 15.9 per 100 000 population among males and Cancer of the colon and rectum are 11.2 among females (Appendix A, Table 1-4). rare in developing countries but are the second most frequent malignancy in affluent societies; Mortality over 940 000 cases occur annually worldwide (Bernard et al., 2003). The average five years The total number of colorectal cancer survival rate was about 50%.The majority of deaths was 445 cases, 261 cases among males cancer occurring in the colon and rectum are and 184 cases among females, accounting adenocarcinoma. about 8.1% of all cancer deaths in males and In Chonburi over the period 2003- 6.8% in females with sex ratio male to female 2007, colorectal cancer was the third leading was 1.4:1. The average age-standardized cancer and the third leading cause of cancers mortality rates were 10.2 per 100 000 deaths in males after lung cancer and liver population among males and 4.2 among cancer. In females it was the fourth after females (Appendix. A, Table 19-22). breast, cervix and lung cancer and also be the fourth common cause of cancer deaths after Data Quality cervix, breast and lung cancer. The data quality was rather good with Incidence high percentage of histological verified approximately 81.8% among both males and Over this period, the total number of females. The percentage of death certificate colorectal cancer was 765 cases, 418 cases in only (DCO) was 5.0 in males and 0.4% in males and 347 cases in females, accounting females. The prognosis of this cancer was fair, about 9.8% of all cancers in males and 7.2% in with high level of M/I ratio 62.4% for males females. Sex ratio male to female was 1.2:1. and 53.0% for females (Table 5.1). Males are affected more than females. The

Table 5.1 Data quality of colorectal cancer 2003-2007

Male Female Number Rates Number Rates New cancer 418 15.9 347 11.2 Cancer death 261 10.2 184 4.2 Data quality Percentage Percentage Histology proof 81.8 81.8 Death Certificate Only 5.0 0.4 M/I Ratio 62.4 53.0

Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 5.1 Age-specific incidence and mortality rates of colorectal cancer

600

500

000 , 400

100 300

200

Incidence per per Incidence 100

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85

Age Group IncidenceMortality MaleMale IncidenceMortality FemFemaleale MortalityMortality Male MortalityMortality FemFemaleale

Figure 5.2 Geographic distributions by districts and sexes of colorectal cancer

Male Female

17.7 Muang 13.7 16.6 Ban Bung 7.8 6.2 Nong Yai 5.2 24.8 Bang La Mung 15.2 10.6 Phan Thong 8.7 15.6 Phanat Nikhom 9.2 10.7 Sri Racha 8.5 13.3 Ko Si Chang 15.9 16.8 Sattahip 16.5 10.4 Bo Thong 5.3 8.4 Ko Chan 10.5

30 25 20 15 10 5 0 0 10 20 30

29 Oral cavity cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 5.3 Comparisons of colorectal cancer with the others

Male Female

15.9 11.2 Chonburi (2003-2008) 12.7 Chonburi (1998-2002) 9.1

9.4 7.7 Lopburi (1998-2002)** 9.3 Phistsanulok (1998-2002)** 6.5

11.6 Lampang (1998-2002)** 9.5 8.7 Lamphun (1998-2002)** 7.4

9.2 Chiang Mai (1998-2000)* 7.8 7.3 Rayong (1998-2000)* 6.5

12.4 Bangkok (1998-2000)* 9.6 10.2 Songkhla (1998-2000)* 7.4 Prachuap Khiri Khan (1998-2000)* 7.7 4.9 8.6 Khon Kaen (1998-2000)* 7.0 Udon Thani (1998-2000)* 11.9 8.5 5.5 Nakhon Phanom (1998-2000)* 4.8

20 15 10 5 0 0 5 10 15 20

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 5.4 Trends of incidence and mortality of colorectal cancer (1998-2007)

10 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons. 30

Liver cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Liver Cancer Mortality Liver cancer is the fifth most common among men worldwide and it is a major health The total number of liver cancer deaths problem in developing countries. About 560 was 667 cases, 502 among males and 165 000 new cases of liver cancer, usually among females, accounting about 16.0% of all hepatocellular carcinoma, occur annually and cancer deaths in males and 6.1% in females. contribute significantly to cancer mortality The average age-standardized mortality rates worldwide. More then 80% cases occur in Asia were 18.8 per 100 000 population among males and Africa. The incidence rate is more than and 5.3 among females (Appendix A, Table 19- twice as high in men as in women. Survival of 22). disease is less than six months; five years survival only 10% (Bernard et al., 2003). Data Quality In Chonburi during 2003-2007, cancer of the liver was the second leading cancer and The quality of data on liver cancer was second leading cause of cancers death in males poor due to low level of histological verified after lung cancer while it was the fifth leading (22.9% in males and 23.5% in females). It is cancer and the fifth leading cause of cancers very difficulty to get tissue diagnosis. death after cervical cancer, breast cancer, Approximately one fifth of liver cancer cases colorectal cancer and lung cancer in females. had the histological diagnosis and high level of Over this period, the total number of death certificate only (13.6% in males and liver cancer was 741 cases, 558 cases in males 12.0% in females). The prognosis of liver and 183 cases in females, accounting about cancer was very poor, with high level of M/I 13.0% of all cancers in females, and 3.8% in ratio 90% in males and 90.2% in females (Table females. Males were affected more than 6.1). females. Sex ratio male to female was 3:1. The average age-standardized incidence Hepatocellular carcinoma was the most rates were 20.9 per 100 000 among males and common cell type in both males and females 5.9 per 100 000 among females (Appendix A, (75% among males and 72% among females) Table 1-4). which are shown in table 3.2.

Table 6.1 Data quality of liver cancer, 2003-2007

Male Female Number Rates Number Rates New cancer 558 20.9 183 5.9 Cancer death 502 18.8 165 5.3 Data quality Percentage Percentage Histology proof 22.9 23.5 Death Certificate Only 13.6 12.0 M/I Ratio 90.0 90.2

Liver cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 6.2 Morphology of liver cancer in Chonburi (2003-2007)

Male Female Molophology Number Percentage Number Percentage Hepatocellular carcinoma 96 75 31 72.0 Cholangiocarcinoma 15 11.7 6 14.0 Adenocarcinoma 15 11.7 6 14.0 Others 2 1.6 - Total 128 100 43 100

Figure 6.1 Age-specific incidence and mortality rates of liver cancer

250

200 000 ,

100 150

100

Incidence per per Incidence 50

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 6.2 Geographic distribution by districts and sexes of liver cancer

Male Female

24.4 Muang 6.3 18.6 Ban Bung 7.0 22.3 Nong Yai 0.0 22.2 Bang La Mung 6.9 21.3 Phan Thong 3.0 18.5 Phanat Nikhom 4.1 20.0 Sri Racha 6.1 48.4 Ko Si Chang 0.0 18.6 Sattahip 5.7 13.1 Bo Thong 6.3 26.2 Ko Chan 9.4

60 50 40 30 20 10 0 0 10 20 30 40 50 60

Liver cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 6.3 Comparisons of liver cancer with the others

Female Male

5.9 20.9 Chonburi(2003-2007) 18.5 Chonburi(1998-2002) 6.6 7.0 23.8 Lopburi(1998-2002)** 18.2 Phistsanulok(1998-2002)** 4.6 30.6 Lampang(1998-2002)** 14.2 15.3 Lamphun(1998-2002)** 5.2 17 Chiang Mai(1998-2000)* 5.8 4.1 14.9 Rayong(1998-2000)* 13.4 Bangkok(1998-2000)* 4.3 7.7 Songkhla(1998-2000)* 2.1 7.3 Prachuap Khiri Khan(1998-2000)* 2.4 78.4 Khon Kaen(1998-2000)* 33.3 113.4 Udon Thani(1998-2000)* 49.8 63.5 Nakhon Phanom(1998-2000)* 31.1

140 120 100 80 60 40 20 0 0 20 40 60 80 100 120 140

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 6.4 Trends of incidence and mortality of liver cancer (1998-2007)

ASR 10

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

33 Lung cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Lung Cancer Mortality

Lung cancer is the most common The total number of lung cancer deaths malignant disease worldwide, with 900 000 new was 1085 cases, 761 among males and 324 cases cases in each year among males and 330 000 among females, accounting about 24.3% of all among females. It is the major cause of death cancer deaths in males and 12.0 % of all cancers from cancer. The five-year survival rate for lung in females. The age-standardized mortality rates cancer cases is less than 15% (Bernard et al., were 30.8 per 100 000 population in males and 2003). 10.9 in females (Appendix A, Table 19-22). In Chonburi over the periods 2003- 2007, lung cancer was the most common Data Quality leading cancer and the most common cause of death from cancer in males while it was the The data quality was fair, about half of third common leading cancer after breast and lung cancer had histological proof. The level of cervical cancer; and the third common cause of histological verified was 58.5% among males cancer death in females after cervical cancer and 59.7% among females and the level of and breast cancer. death certificate only (DCO) was 5.8% among Over this period, the total number of males and 4.2% among females. The prognosis lung cancer was 1367 cases, 935 cases in males of lung cancer was very poor with high level of and 432 cases in females, accounting about mortality and incidence ratio. The M/I ratio 21.8% of all cancers in males and 8.9% of all was 81.4% in males and 75.0% in females cancers in females. (Table 7.1). The average age-standardized incidence Adenocarcinoma was the most rates were 37.9 per 100 000 among males and common cell type in both males and females 14.5 per 100 000 females (Table 7.1). Males are (46.4% among males and 59.2% among affected more than females. Sex ratio male to females) follow by Squamous cell carcinoma female was 2.2:1 (Appendix A, Table 1-4). 37% for males and 17% for females (Table 7.2).

Table 7.1 Data quality of lung cancer, 2003-2007

Male Female Number Rates Number Rates New cancer 935 37.9 432 14.5 Cancer death 761 30.8 324 10.9 Data quality Percentage Percentage Histology proof 58.8 59.7 Death Certificate Only 5.8 4.2 M/I Ratio 81.4 75.0

Lung cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Table 7.2 Morphology of lung cancer in Chonburi (2003-2007)

Male Female Molophology Number Percentage Number Percentage Squamous cell carcinoma 151 37.0 35 17.0 Adenocarcinoma 189 46.4 122 59.2 Others 67 16.5 52 25.2

Total 407 100 206 100

Figure 7.1 Age-specific incidence and mortality rates of lung cancer

450 400 350

000 300 ,

100 250

200 150 Incidence per per Incidence 100 50 0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 7.2 Geographic distribution by districts and sexes of lung cancer

Male Female

44.1 Muang 16.7 30.8 Ban Bung 18.6 35.9 Nong Yai 9.0 46.3 Bang La Mung 20.6 37.9 Phan Thong 12.8 34.5 Phanat Nikhom 9.5 31.9 Sri Racha 10.6 67.0 Ko Si Chang 22.1 Sattahip 34.3 16.2 Bo Thong 35.6 7.8 36.0 Ko Chan 9.0

0 20 40 60 80 80 60 40 20 0

35 Lung cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 7.3 Comparisons of lung cancer to the others

Male Female

14.5 37.9 Chonburi (2003-2007) 10.5 31 Chonburi (1998-2002) 5.8 21.4 Lopburi (1998-2002)** 19.4 Phistsanulok (1998-2002)** 5.6 50.1 Lampang (1998-2002)** 26.7 19.7 31.9 Lamphun (1998-2002)** 22.3 29.6 Chiang Mai (1998-2000)* 25.1 Rayong (1998-2000)* 7.5 18.4 Bangkok (1998-2000)* 6.5 13.5 Songkhla (1998-2000)* 4.9 12.1 Prachuap Khiri Khan (1998-2000)* 2.8 20.6 Khon Kaen (1998-2000)* 7.1 26.3 Udon Thani (1998-2000)* 8.3 7 Nakhon Phanom (1998-2000)* 3.7 0 10 20 30 40 50 60 60 50 40 30 20 10 0

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 7.4 Trends of incidence and mortality of lung cancer (1998-2007)

45 40

ASR 20

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

Leukemia cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Leukemia Mortality Leukemia is the eleventh most common cancer worldwide with more than 250 000 new The total number of leukemia deaths cases each year. It is malignant transformation was 270 cases, 148 among males and 122 of white blood cells or their precursors. among females, accounting about 4.3% of all Survival varies greatly according to type, with cancer deaths in males and 3.8% in females. acute lymphoblastic leukemia having a five-year The average age-standardized mortality rates survival rate of about 70%, while only 20-30% were 3.7 per 100 000 population among males for acute myeloid leukemia. and 3.5 among females (Appendix A, Table 19- In Chonburi during 2003-2007, 22). leukemia was the seventh leading cancer in males and the eighth in females. It was not Data Quality included in the tenth leading cause of death in both males and females. The quality of data of leukemia was Over this period, the total number of good due to high level of histological verified leukemia was 366 cases, 185 cases in males and (100% in both males and females). The level 181 cases in females, accounting about 4.3% of of death certificate only was 0.0% in both males all cancers in males, and 3.8% in females. Sex and females. The prognosis of leukemia was ratio male to female was 1:1. rather fair; the level of mortality and incidence The average age-standardized incidence ratio was 80.0% in males and 67.4% in females rates were 7.2 per 100 000 among males and 6.4 (Table 8.1). per 100 000 among females (Appendix A, Table 1-4). Leukemia was the major cancer in children both boys and girls under age of 15.

Table 8.1 Data quality of leukemia, 2003-2007

Male Female Number Rates Number Rates New cancer 185 7.2 181 6.4 Cancer death 148 3.7 122 3.5 Data quality Percentage Percentage Histology proof 100 100 Death Certificate Only 0.0 0.0 M/I Ratio 80.0 67.4

Leukemia cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 8.1 Age-specific incidence and mortality rates of leukemia

25 000 , 100 20

Incidence per 10

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 8.2 Geographic distribution by districts and sexes of leukemia

Male Female

7.5 Muang 6.9 9.2 Ban Bung 7.2 0.0 Nong Yai 2.5 7.3 Bang La Mung 5.1 6.6 Phan Thong 2.0 4.1 Phanat Nikhom 3.7 3.5 Sri Racha 6.5 0.0 Ko Si Chang 0.0

9.3 Sattahip 4.6 6.4 Bo Thong 4.8 8.0 Ko Chan 7.3

10 8 6 4 2 0 0 2 4 6 8 10 12

Leukemia cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 8.3 Comparisons of leukemia to the others

Male Female

6.5 Chonburi(2003-2007) 5.4 4.9 Chonburi(1998-2002) 4.0 4.4 Lopburi(1998-2002)** 3.7 4.9 Phistsanulok(1998-2002)** 3.2 4.8 Lampang(1998-2002)** 4.2 3.1 Lamphun(1998-2002)** 2.8 6.7 Chiang Mai(1998-2000)* 4.1 3.6 Rayong(1998-2000)* 2.5 4.6 Bangkok(1998-2000)* 3.0 5.1 Songkhla(1998-2000)* 3.9 4.1 Prachuap Khiri Khan(1998-2000)* 2.4 5.1 Khon Kaen(1998-2000)* 3.0 3.3 Udon Thani(1998-2000)* 1.9 1.1 Nakhon Phanom(1998-2000)* 0.7

10 8 6 4 2 0 0 2 4 6 8 10

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 8.4 Trends of incidence and mortality of leukemia (1998-2007)

ASR 4

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons

Breast cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Breast Cancer Table 10.1 Data quality of breast cancer 2003-2007 Breast cancer is the most common cancer in females and in many regions including Data Quality Europe and Australia; with more than one million cases occurring worldwide annually, it is The data quality of breast cancer was still the most common cause of death from good, with the high level of histological verified cancer in women. Five-year survival rates are (90.2%) and low level of death certificate only higher than 70% in most developed countries (1.2%) in female breast due to easily to get (Bernard et al., 2003). tissue diagnosis especially fine needle aspiration In Chonburi during the period 2003- and improvement of combination of therapy. 2007, breast cancer was the most common The prognosis breast cancer was good with low leading cancer and the second common level of M/I ratio 42.9% in males and 39% in cause of cancer deaths after cervical cancer females (Table 10.1). in females. The total number of breast cancer was Age-specific incidence rates of female 1085 cases, 7 cases in males and 1078 cases in breast cancer females, accounting about 0.2% of all cancers in males and 22.3% in females. Sex ratio male Age-specific incidence rates of female to female was 1:68. breast cancer showed the incidence rates The average age-standardized incidence increased at the age 30, reaching a peak at the rate was 0.2 per 100 000 population among age 50 and declined after this age (Figure 10.1). males and 31.5 per 100 000 population among females (Appendix A, Table1-4). Age-specific mortality rates of female breast cancer Mortality Age-specific mortality rates of female The total number of cancer deaths from breast cancer showed the mortality rates breast cancer was 430 cases, 3 cases in males increased at the age of 35, reaching a peak at and 427 cases in females, accounting about the age of 65 and declined after this age (Figure 0.1% of all cancer death in males and 13.0% of 10.1). all cancers in females. The average age- The incidence and mortality rates of standardized mortality rate was 0.1 per 100 000 breast cancer in Chonburi are increasing which population among males and 13.0 among are shown in figure 10.4. females (Appendix A, Table 19-22).

Table 10.1 Data quality of breast cancer 2003-2007

Male Female Number Rates Number Rates New cancer 7 0.2 1078 31.5 Cancer death 3 0.1 428 13.0 Data quality Percentage Percentage Histology proof 71.4 90.2 Death Certificate Only 0 1.2 M/I Ratio 42.9 39

40 Breast cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 10.1 Age-specific incidence and mortality rates of female breast cancer

120

100

000 80 , 100 60

Incidence per per Incidence 20

0 4 9 + 0- 5- -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 85 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80

Age Group

Incidence Female Mortality Female

Figure 10.2 Geographic distribution by districts of female breast cancer

Female

Muang 39.4 Ban Bung 28.5 Nong Yai 28.7 Bang La Mung 37.6 Phan Thong 25.4 Phanat Nikhom 20.1 Sri Racha 27.0 Ko Si Chang 40.5 Sattahip 30.0 Bo Thong 28.0 Ko Chan 30.2

0 10 20 30 40 50

Breast cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 10.3 Comparisons of female breast cancer to the others

Female

Chonburi (2003-2007) 31.5 Chonburi (1998-2002) 24.2 Lopburi (1998-2002)** 21.8 Phistsanulok (1998-2002)** 15.0 Lampang (1998-2002)** 21.0 Lamphun (1998-2002)** 20.5 Chiang Mai (1998-2000)* 20.7 Rayong (1998-2000)* 22.0 Bangkok (1998-2000)* 24.3 Songkhla (1998-2000)* 17.2 Prachuap Khiri Khan (1998-2000)* 16.0 Khon Kaen (1998-2000)* 13.7 Udon Thani (1998-2000)* 13.0 Nakhon Phanom (1998-2000)* 10.1

0 10 20 30 40

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 10.4 Trends of incidence and mortality of female breast cancer (1998-2007)

20 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Female Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

Cervical cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Cervical Cancer Mortality Cervical cancer is the second most common cancer of women worldwide with The total number of cancer deaths of more then 470 000 new cases per year of about cervical cancer was 487 cases accounting about 230 000 deaths every year, more than 80% 18.0% of all cancer deaths. The average age- occur in developing countries. Five-year standardized mortality was 15.1 per 100 000 survival rates are up to 70% (Bernard et al., females population. It was the most common 2003) cause of death from cancer in females (Table In Chonburi over the periods 2003- 11.1) and (Appendix A, Table 19-22) 2007, the cancer of the cervix was the second leading cancer after breast cancer while it was Data Quality the most common cause of cancer deaths among females. The cancer of the cervix was quite The total number of cervical cancer good, with the high level of histological verified was 866 cases accounting about 17.9% of all (86.0%) and low level of death certificate only female cancers. The incidence rate was slightly (0.7%). This is regarded as an indicator of declined (Figure 11.4). better data quality and high degree of The average age-standardized incidence completeness. The prognosis was rather good rate during this period was 25.8 per 100 000 with low level of M/I ratio 56.2% (Table 11.1). females population (Appendix A, Table 1-4).

Table 11.1 Data quality of cervical cancer, 2003-2007

Number Rates New cancer 866 25.8 Cancer death 487 15.1 Data quality Percentage Histology proof 86 Death Certificate Only 0.7 M/I Ratio 56.2

Figure 11.1 Age-specific incidence and mortality rates of cervical cancer

120

100

000 80 , 100 60

per Incidence 20

0 4 9 + 0- 5- -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 85 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 Age Group

Incidence Female Mortality Female 43 Cervical cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 11.2 Geographic distribution by districts of cervical cancer

Female

Muang 23.8 Ban Bung 21.4

Nong Yai 29.0 Bang La Mung 40.8 Phan Thong 21.7 Phanat 18.6 Nikhom 23.5

Sri Racha 64.0 Ko Si Chang Sattahip 34.8 Bo Thong 9.4 Ko Chan 14.3

0 20 40 60 80

Figure 11.3 Comparisons of cervical cancer with the others

Female

Chonburi (2003-2007) 25.8 Chonburi (1998-2002) 30.1 Lopburi (1998-2002)** 21.8 Phistsanulok (1998-2002)** 15.4 Lampang (1998-2002)** 22.2 Lamphun (1998-2002)** 26.0 Chiang Mai (1998-2000)* 29.4 Rayong (1998-2000)* 28.5 Bangkok (1998-2000)* 19.3 Songkhla (1998-2000)* 20.6 Prachuap Khiri Khan (1998-2000)* 21.2 Khon Kaen (1998-2000)* 15.9 Udon Thani (1998-2000)* 19.5 Nakhon Phanom (1998-2000)* 11.3

0 10 20 30 40

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Cervical cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 11.4 Trends of incidence and mortality of cervical cancer (1998-2007)

20 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year Incidence Female mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons

Figure 11.5 Number of carcinoma in situ of cervix by year (1998-2007)

40 Number 30

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

female

Prostatel cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Prostate Cancer Mortality Prostate cancer is the third most common cancer in men worldwide with more The total number of cancer deaths of then 543 000 new cases per year of about 200 prostate cancer was 108 cases accounting about 000 deaths every year, more than 80% occur in 3.4% of all cancer deaths. The average age- developed countries, predominantly afflicting standardized mortality was 4.5 per 100 000 older men (Bernard et al., 2003). The majority males population. It was the sixth common of cases are adenocarcinoma. cause of death from cancer in males (Table 12.1 In Chonburi over the periods 2003- and Appendix A, Table 19-22). The mortality 2007, the cancer of the prostate was the forth of prostate cancer in Chonburi is also leading cancer after lung, liver and colorectal increasing (Figure 12.4). cancer while it was the sixth common cause of Incidence and mortality rates increase cancer deaths after lung, liver, colorectal, oral with aging with peaks within seventh decade cavity and esophagus. (Figure 12.1). Over this period, the total number of prostate cancer was 212 cases accounting about Data Quality 4.9% of all male cancers. The average age-standardized incidence The data quality of the prostate cancer rate during this period was 8.8 per 100 000 was rather fair. The level of histological verified males population (Appendix A, Table 1-4). The was 70.8% and the level of death certificate incidence rates of prostate cancer in Chonburi only was 4.7%. This is regarded as an indicator are increasing partly (Figure 12.4) as a result of of data quality. . The prognosis was rather good screening for elevated levels of prostate– with low level of M/I ratio 50.9% (Table 12.1). specific antigen.

Table 12.1 Data quality of prostate cancer, 2003-2007

Number Rates New cancer 212 8.8 Cancer death 108 4.5 Data quality Percentage Histology proof 70.8 Death Certificate Only 4.7 M/I Ratio 50.9

Prostatel cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 12.1 Age-specific incidence and mortality rates of prostate cancer

200 180 160 140 000 , 120 100 100 80 60 Incidence per per Incidence 40 20 0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85

Age Group

Incidence male Mortality male

Figure 12.2 Geographic distribution by districts of prostate cancer

Male

11.6 Muang 5.8 Ban Bung 15.7 Nong Yai 14.4 Bang La Mung 3.1 Phan Thong 6.7 Phanat Nikhom 6.7 Sri Racha 0.0 Ko Si Chang 12.0 Sattahip 1.8 Bo Thong 4.5 Ko Chan

20 15 10 5 0

Prostatel cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 12.3 Comparisons of prostate cancer with the others

Male

8.8 Chonburi (2003-2008) 5.9 Chonburi (1998-2002) 4.2 Lopburi (1998-2002)** 5.7 Phistsanulok (1998-2002)** 4.8 Lampang (1998-2002)** 2.4 Lamphun (1998-2002)** 4.6 Chiang Mai (1998-2000)* 3.9 Rayong (1998-2000)* 6.7 Bangkok (1998-2000)* 4.1 Songkhla(1998-2000)* 2.6 Prachuap Khiri Khan(1998-2000)* 2.9 Khon Kaen(1998-2000)* 3.8 Udon Thani(1998-2000)* 1.7 Nakhon Phanom(1998-2000)*

10 8 6 4 2 0

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok, and Lopburi

Figure 12.4 Trends of incidence and mortality of female prostate cancer (1998-2007)

6 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Mortality Male Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

Bladder cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of bladder cancer 100 000 population in males and 1.0 per 100 000 population in females (Appendix A, Table Bladder cancer is the ninth most 1-4). common cancer worldwide, with 330 000 new and more than 130 000 deaths per year. More Mortality than 90% of bladder cancers are transitional cell carcinoma (Bernard et al., 2003). The average The total number of bladder cancer five years survival rate was about 50%.The deaths was 127 cases, 102 cases among males majority of cancer occurring in the colon and and 25 cases among females, accounting about rectum are adenocarcinoma. 3.3% of all cancer deaths in males and 0.9% in In Chonburi over the period 2003-2007, females with sex ratio of bladder cancer deaths, bladder cancer was the tenth leading cancer male to female was 4:1. The average age- among males after cancer of the lung, liver, standardized mortality rates were 4.0 per 100 colorectal, prostate, oral cavity, skin, leukemia, 000 population among males and 0.9 among lymphoma and esophagus and not included in females (Appendix. A, Table 19-22). the ten leading cause of cancer deaths. In females it was not included in the ten leading Data Quality new cancers and also not be included in the ten leading cause of cancer deaths. The data quality was rather good. The percentage of histological verified was 79.1% Over this period, the total number of among males and 80.0 among females. The bladder cancer was 183 cases, 153 cases in percentage of death certificate only (DCO) was males and 30 cases in females, accounting about 1.3% in males and 0.0% in females. The 3.6% of all cancers in males and 0.6% in prognosis of this cancer was fair, with high females. Sex ratio male to female was 5:1. Males level of M/I ratio 66.7% for males and 833% are affected more than females. The average for females (Table 13.1). age-standardized incidence rates were 6.1 per

Table 13.1 Data quality of bladder cancer, 2003 -2007

Male Female Number Rates Number Rates New cancer 153 6.1 30 1.0 Cancer death 102 4.0 25 0.9 Data quality Percentage Percentage Histology proof 79.1 80.0 Death Certificate Only 1.3 0.0 M/I Ratio 66.7 83.3

Bladder cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 13.1 Age-specific incidence and mortality rates of bladder cancer

120

100

000 80 , 100 60

40 Incidence per per Incidence

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 13.2 Geographic distributions by districts and sexes of bladder cancer

Male Female

0.0 Muang 1.9 6.0 Ban Bung 1.5 3.5 Nong Yai 0.0 11.4 Bang La Mung 1.2 8.2 Phan Thong 0.5 3.8 Phanat Nikhom 0.0 3.4 Sri Racha 0.7 10.5 Ko Si Chang 0.0 7.3 Sattahip 0.4 3.3 Bo Thong 0.0 5.8 Ko Chan 2.1

20 15 10 5 0 0 5 10 15 20

Bladder cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 13.3 Comparisons of bladder cancer with the others

Male Female

6.1 Chonburi(2003-2008) 1.0 6.9 Chonburi(1998-2002) 1.1 3.7 Lopburi(1998-2002)** 1.1 3.0 Phistsanulok(1998-2002)** 0.6 5.3 Lampang(1998-2002)** 1.5 3.1 Lamphun(1998-2002)** 0.9 4.8 Chiang Mai(1998-2000)* 2.1 7.0 Rayong(1998-2000)* 2.1 5.9 Bangkok(1998-2000)* 1.8 4.5 Songkhla(1998-2000)* 0.8 2.1 Prachuap Khiri Khan(1998-2000)* 0.3 4.1 Khon Kaen(1998-2000)* 0.6 4.3 Udon Thani(1998-2000)* 1.4 0.0 2.3 Nakhon Phanom(1998-2000)* 0 2 4 6 8 10 10 8 6 4 2 0

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 13.4 Trends of incidence and mortality of bladder cancer (1998-2007)

5 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

51 Thyroid cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Thyroid Cancer

In Chonburi during 2003-2007, cancer Mortality of the thyroid cancer was the eighth leading cancer in females. But it was not the ten leading The total number of Thyroid cancer cancer in males and it was not included in the deaths was 62 cases, 17 among males and 45 ten leading cause of cancer deaths in both among females, accounting about 0.5% of all males and females. cancer deaths in males and 1.7% in females. Over this period, the total number of The average age-standardized mortality rates Thyroid cancer was 223 cases, 37 cases in males were 0.6 per 100 000 population among males and 186 cases in females, accounting about and 1.4 among females (Appendix A, Table 19- 0.9% of all cancers in males, and 3.9% in 22). females. Females were affected more than males. Sex ratio male to female was 1:5. Data Quality The average age-standardized incidence rates were 1.3 per 100 000 population among The quality of data of thyroid cancer males and 5.5 per 100 000 population among was good due to high level of histological females (Appendix A, Table 1-4). The incidence verified (83.8% in males and 91.4% in females). rates are slightly increasing, especially in females It is easily to get tissue diagnosis and low level (Figure 14.4) of death certificate only (0.0% in males and Papillary carcinoma was the most 1.1% in females). The prognosis of thyroid common approximately 70% of all thyroid cancer was very good, with low level of M/I cancers follow by 16% of follicular carcinoma ratio 45.9% in males and 24.2% in females (Table 14.2). (Table 14.1). Table 14.1 Data quality of thyroid Cancer, 2003-2007

Male Female Number Rates Number Rates New cancer 37 1.3 186 5.5 Cancer death 17 0.6 45 1.4 Data quality Percentage Percentage Histology proof 83.8 91.4 Death Certificate Only 0.0 1.1 M/I Ratio 45.9 24.2

Table 14.2 Morphology of thyroid cancer in Chonburi (2003-2007)

Morphology Number Percentage Papillary carcinoma 133 70.0 Follicular carcinoma 31 16.0 Papillary and Follicular 12 6.3 Anaplastic carcinoma 9 4.7 Others 16 8.4 Total 201 100

Thyroid cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 14.1 Age-specific incidence and mortality rates of thyroid cancer

25 000 ,

100 20

Incidence per 10

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 14.2 Geographic distribution by districts and sexes of thyroid cancer

Male Female

1.9 Muang 6.4 1.7 Ban Bung 5.8 1.4 Nong Yai 4.6 1.5 Bang La Mung 6.1 0.5 Phan Thong 8.6 2.7 Phanat Nikhom 4.5 0.2 Sri Racha 4.1 0.0 Ko Si Chang 0.0 0.7 Sattahip 6.0 0.0 Bo Thong 5.1 0.0 Ko Chan 2.3

10 8 6 4 2 0 0 2 4 6 8 10

Thyroid cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 14.3 Comparisons of thyroid cancer to the others

Male Female

1.3 Chonburi(2003-2008) 5.5 0.9 Chonburi(1998-2002) 3.9 0.8 Lopburi(1998-2002)** 3.9 0.4 Phistsanulok(1998-2002)** 1.9 0.8 Lampang(1998-2002)** 3.5 0.9 Lamphun(1998-2002)** 1.8 1.2 Chiang Mai(1998-2000)* 4.3 0.9 Rayong(1998-2000)* 3.7 1.2 Bangkok(1998-2000)* 3.9 1.3 Songkhla(1998-2000)* 5.7 0.1 Prachuap Khiri Khan(1998-2000)* 0.9 1.2 Khon Kaen(1998-2000)* 4.6 0.6 Udon Thani(1998-2000)* 1.8 0.1 Nakhon Phanom(1998-2000)* 0.9

10 8 6 4 2 0 0 2 4 6 8 10

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 14.4 Trends of incidence and mortality of thyroid cancer (1998-2007)

4 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons

Lymphoma cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Incidence of Lymphoma Mortality The incidence of malignant non- Hodgkin lymphoma is increasing worldwide The total number of lymphoma cancer more than 280 000 new cases occur annually, deaths was 196 cases, 112 among males and 84 predominantly in more developed countries. among females, accounting about 3.8% of all Hodgkin disease afflicts mainly children cancer deaths in males and 3.1% in females. and elderly in developing countries and young The average age-standardized mortality rates adult in more developed countries about 62 000 were 4.1 per 100 000 population among males new cases are diagnosed annually (Bernard et al., and 2.8 among females (Appendix A, Table 19- 2003). 22). In Chonburi during 2003-2007, malignant tumor of lymph nodes (Lymphoma) Data Quality was the eighth leading cancer in males and the tenth in females. It was not included in the The quality of data of thyroid cancer tenth leading cause of deaths in both males and was good due to high level of histological females. verified (100% in both males and females). The Over this period, the total number of level of death certificate only was 0.0% in lymphoma cancer was 329 cases, 178 cases in both males and females. The prognosis of males and 151 cases in females, accounting lymphoma was rather fair; the level of Mortality about 4.1% of all cancers in males, and 3.1% in and Incidence ratio was 62.9% in males and females. Males were affected more than 55.6% in females (Table 15.1). females. Sex ratio male to female was 1.2:1. The incidence and mortality rates were The average age-standardized incidence slightly decreasing (figure 15.4) rates were 6.2 per 100 000 among males and 5.1 per 100 000 among females (Appendix A, Table 1-4).

Table 15.1 Data quality of lymphoma, 2003-2007

Male Female Number Rates Number Rates New cancer 178 6.2 151 5.1 Cancer death 112 4.1 84 2.8 Data quality Percentage Percentage Histology proof 100 100 Death Certificate Only 0.0 0.0 M/I Ratio 62.9 55.6

Lymphoma cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 15.1 Age-specific incidence and mortality rates of lymphoma

35 30 000 , 25 100 20 15

10 Incidenceper 5

0 4 9 - - -19 -19 -24 -29 -34 -39 -44 -49 -54 -59 -64 -69 -74 -79 -84 + 0 5 14 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Age Group

Incidence Male Incidence Female Mortality Male Mortality Female

Figure 15.2 Geographic distribution by districts and sexes of lymphoma

Male Female

6.0 6.3 Muang 4.9 Ban Bung 4.4 3.8 Nong Yai 4.2 8.7 Bang La Mung 6.2 4.7 Phan Thong 4.2 7.5 Phanat Nikhom 3.9 4.2 Sri Racha 3.1 0.0 Ko Si Chang 14.8 7.3 Sattahip 6.4 4.5 Bo Thong 5.3 Ko Chan 3.8 5.9 20 15 10 5 0 0 5 10 15 20

Figure 15.3 Comparisons of lymphoma to the others

Lymphoma cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Male Female

6.2 Chonburi (2003-2007) 5.1 5.1 Chonburi (1998-2002) 3.1 4.5 Lopburi (1998-2002)** 2.9 3.1 Phistsanulok (1998-2002)** 3.4 6.0 Lampang (1998-2002)** 4.4 5.9 Lamphun (1998-2002)** 4.7 3.8 Chiang Mai (1998-2000)* 3.1 5.0 Rayong (1998-2000)* 3.4 2.7 Bangkok (1998-2000)* 2.3 3.6 Songkhla (1998-2000)* 4.5 1.8 Prachuap Khiri Khan (1998-2000)* 2.4 4.6 Khon Kaen (1998-2000)* 3.1 5.4 Udon Thani (1998-2000)* 3.3 0.3 Nakhon Phanom (1998-2000)* 0.5

10 8 6 4 2 0 0 2 4 6 8 10

*From Cancer in Thailand Vol. IV **From Cancer in Lamphun,Lampang,Phitsanulok and Lopburi

Figure 15.4 Trends of incidence and mortality of lymphoma (1998-2007)

4 ASR

0 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year

Incidence Male Incidence Female Mortality Male Mortality Female

Rate = Annual age-standardized incidence/mortality rate per 100 000 persons.

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

16. PATHOLOGY

Table 16. Pathology according to sites and sexs of all cancers

Pathology And Sites Male Female Total

TOTAL 4330 4857 9187

C00 LIP 13 32 45 C00.0 EXTERNAL UPPER LIP 1 3 4 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 0 2 2 Mucoepidermoid carcinoma 1 0 1

C00.1 EXTERNAL LOWER LIP 1 6 7 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 1 5 6

C00.3 MUCOSA OF UPPER LIP 0 1 1 Squamous cell carcinoma, NOS 0 1 1

C00.4 MUCOSA OF LOWER LIP 1 12 13 Verrucous carcinoma, NOS 0 3 3 Squamous cell carcinoma, NOS 1 9 10

C00.6 COMMISSURE OF LIP 0 1 1 Squamous cell carcinoma, NOS 0 1 1

C00.9 LIP, NOS 10 9 19 No histological proof 5 5 10 Squamous cell carcinoma, NOS 5 4 9

C01 TONGUE 105 32 137 C01.9 BASE OF TONGUE, NOS 22 1 23 Squamous cell carcinoma, NOS 19 1 20 Squamous cell carcinoma, keratinizing, NOS 1 0 1 Adenoid cystic carcinoma 1 0 1 Mucoepidermoid carcinoma 1 0 1

C02.1 BORDER OF TONGUE 1 0 1 Squamous cell carcinoma, NOS 1 0 1

58 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C02.3 ANTERIOR 2/3 OF TONGUE, NOS 0 1 1 Squamous cell carcinoma, NOS 0 1 1

C02.9 TONGUE, NOS 82 30 112 No histological proof 10 1 11 Carcinoma, NOS 1 0 1 Verrucous carcinoma, NOS 1 1 2 Squamous cell carcinoma, NOS 66 27 93 Squamous cell carcinoma, keratinizing, NOS 3 1 4 Squamous cell carcinoma large cell, nonkeratinizing, NOS 1 0 1

C03 GUM 13 16 29 C03.0 UPPER GUM 2 2 4 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Malignant lymphoma, NOS 1 0 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1

C03.1 LOWER GUM 4 7 11 Squamous cell carcinoma, NOS 4 7 11

C03.9 GUM, NOS 7 7 14 No histological proof 1 1 2 Squamous cell carcinoma, NOS 5 6 11 Kaposi sarcoma 1 0 1

C04 FLOOR OF MOUTH 20 5 25 C04.1 LATERAL FLOOR OF MOUTH 0 1 1 Papillary carcinoma, NOS 0 1 1

C04.9 FLOOR OF MOUTH 20 4 24 No histological proof 1 0 1 Squamous cell carcinoma, NOS 18 4 22 Adenoid cystic carcinoma, NOS 1 0 1

C05 PALATE 34 9 43 C05.0 HARD PALATE 5 5 10 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 4 4 8 Malignant lymphoma, NOS 1 0 1

59 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C05.1 SOFT PALATE, NOS 25 2 27 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 24 1 25 Squamous cell carcinoma large cell, nonkeratinizing, NOS 1 0 1

C05.2 UVULA 2 0 2 Squamous cell carcinoma, NOS 2 0 2

C05.9 PALATE, NOS 2 2 4 No histological proof 0 1 1 Squamous cell carcinoma, NOS 2 1 3

C06 MOUTH 22 31 53 C06.0 CHEEK MUCOSA 12 21 33 No histological proof 2 0 2 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 9 14 23 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Squamous cell carcinoma large cell, nonkeratinizing, NOS 0 1 1 Adenoid cystic carcinoma, NOS 0 1 1 Mucoepidermoid carcinoma 1 1 2 Adenosquamous carcinoma 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 0 1 1

C06.2 RETROMOLAR AREA 3 1 4 Squamous cell carcinoma, NOS 2 1 3 Squamous cell carcinoma large cell, nonkeratinizing, NOS 1 0 1

C06.9 MOUTH, NOS 7 9 16 No histological proof 2 2 4 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 4 4 8 Adenoid cystic carcinoma 0 2 2 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C07 PAROTID GLAND 8 11 19 C07.9 PAROTID GLAND 8 11 19 Carcinoma, NOS 1 0 1 Carcinoma undifferentiated, NOS 0 1 1 60 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Carcinoma, anaplastic, NOS 1 0 1 Squamous cell carcinoma, NOS 1 0 1 Adenocarcinoma, NOS 1 1 2 Adenoid cystic carcinoma, NOS 1 2 3 Neuroendocrine carcinoma, NOS 1 0 1 Mucoepidermoid carcinoma 2 5 7 Epithelial-myoepithelial carcinoma 0 1 1 Malignant lymphoma, NOS 0 1 1

C08 UNSPECIFIED MAJOR SALIVARY GLANDS 15 11 26 C08.0 SUBMANDIBULAR GLAND 7 5 12 No histological proof 5 2 7 Squamous cell carcinoma, NOS 0 1 1 Adenoid cystic carcinoma, NOS 1 1 2 Mucoepidermoid carcinoma 1 1 2

C08.1 SUBLINGUAL GLAND 1 0 1 Mucoepidermoid carcinoma 1 0 1

C08.9 MAJOR SALIVARY GLAND, NOS 7 6 13 Carcinoma, NOS 1 0 1 Lymphoepithelial carcinoma 1 0 1 Basal cell adenocarcinoma 0 1 1 Adenoid cystic carcinoma, NOS 2 4 6 Mucoepidermoid carcinoma 1 1 2 Mixed tumor, malignant, NOS 1 0 1

C09 TONSIL 29 9 38 C09.9 TONSIL, NOS 29 9 38 No histological proof 3 0 3 Carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 22 3 25 Squamous cell carcinoma, keratinizing, NOS 1 0 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 1 0 1 Squamous cell carcinoma, spindle cell 1 0 1 Mucoepidermoid carcinoma, NOS 1 0 1 Malignant lymphoma, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 0 4 4

61 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C10 OROPHARYNX 8 2 10 C10.0 VALLECULA 0 1 1 Squamous cell carcinoma, NOS 0 1 1

C10.9 OROPHARYNX, NOS 8 1 9 No histological proof 1 0 1 Squamous cell carcinoma, NOS 6 1 7 Mucoepidermoid carcinoma 1 0 1

C11 NASOPHARYNX 133 58 191 C11.9 NASOPHARYNX, NOS 133 58 191 No histological proof 16 2 18 Carcinoma, NOS 4 3 7 Carcinoma, undifferentiated, NOS 25 12 37 Carcinoma, anaplastic, NOS 1 1 2 Squamous cell carcinoma, NOS 62 30 92 Squamous cell carcinoma, keratinizing, NOS 1 1 2 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 15 5 20 Squamous cell carcinoma, spindle cell 1 0 1 Adenocarcinoma, NOS 2 1 3 Adenoid cystic carcinoma 0 1 1 Mucoepidermoid carcinoma 1 0 1 Adenosquamous carcinoma 0 1 1 Malignant lymphoma, NOS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1 Malignant lymphoma, mixed small and large cell, diffuse 1 0 1 Malignant lymphoma, large B-cell, diffuse, NOS 3 0 3

C12 PYRIFORM SINUS 31 5 36 C12.9 PYRIFORM SINUS 31 5 36 Squamous cell carcinoma, NOS 26 5 31 Squamous cell carcinoma, keratinizing, NOS 3 0 3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 1 0 1 Mucoepidermoid carcinoma 1 0 1

C13 HYPOPHARYNX 12 3 15 C13.0 POSTCRICOID REGION 0 1 1 Squamous cell carcinoma, NOS 0 1 1

62 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C13.8 OVERLAPPING LESION OF HYPOPHARYNX 1 0 1 Squamous cell carcinoma, NOS 1 0 1

C13.9 HYPOPHARYNX, NOS 11 2 13 No histological proof 2 0 2 Carcinoma, NOS 1 1 2 Squamous cell carcinoma, NOS 8 1 9

C14 PHARYNX 6 0 6 C14.0 PHARYNX, NOS 6 0 6 Squamous cell carcinoma, NOS 6 0 6

C15 ESOPHAGUS 151 37 188 C15.3 UPPER THIRD OF ESOPHAGUS 4 0 4 Squamous cell carcinoma, NOS 4 0 4

C15.4 MIDDLE THIRD OF ESOPHAGUS 7 2 9 No histological proof 3 0 3 Carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 4 1 5

C15.5 LOWER THIRD OF ESOPHAGUS 14 3 17 No histological proof 2 0 2 Squamous cell carcinoma, NOS 9 3 12 Adenocarcinoma, NOS 3 0 3

C15.9 ESOPHAGUS, NOS 126 32 158 No histological proof 27 14 41 Carcinoma, NOS 1 4 5 Carcinoma, undifferentiated, NOS 1 1 2 Squamous cell carcinoma, NOS 95 12 107 Carcinoid tumor, NOS 1 0 1 Adenosquamous carcinoma 1 1 2

C16 STOMACH 115 108 223 C16.0 CARDIA, NOS 11 5 16 No histological proof 0 2 2 Adenocarcinoma, NOS 10 3 13 Signet ring cell carcinoma 1 0 1 63 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C16.1 FUNDUS OF STOMACH 2 0 2 Adenocarcinoma, NOS 2 0 2

C16.2 BODY OF STOMACH 0 2 2 Adenocarcinoma, NOS 0 1 1 Signet ring cell carcinoma 0 1 1

C16.3 GASTRIC ANTRUM 1 3 4 Adenocarcinoma, NOS 0 2 2 Signet ring cell carcinoma 1 1 2

C16.4 PYLORUS 1 0 1 Adenocarcinoma, NOS 1 0 1

C16.6 GREATER CURVATURE OF STOMACH, NOS 1 0 1 Signet ring cell carcinoma 1 0 1

C16.8 OVERLAPPING LESION OF STOMACH 1 0 1 Adenocarcinoma, NOS 1 0 1

C16.9 STOMACH , NOS 98 98 196 No histological proof 21 33 54 Carcinoma, NOS 4 2 6 Carcinoma, anaplastic, NOS 0 1 1 Adenocarcinoma, NOS 56 43 99 Adenocarcinoma, intestinal type 1 0 1 Tubular adenocarcinoma 1 0 1 Carcinoid tumor, NOS 1 0 1 Neuroendocrine carcinoma, NOS 1 0 1 Signet ring cell carcinoma 8 16 24 Leiomyosarcoma, NOS 1 1 2 Malignant lymphoma, NOS 1 0 1 Malignant lymphoma, large B-cell, diffuse, NOS 3 2 5

C17 SMALL INTESTINE 11 6 17 C17.0 DUODENUM 3 2 5 Adenocarcinoma, NOS 1 2 3 Sarcoma, NOS 1 0 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

64 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C17.1 JEJUNUM 1 2 3 Leiomyosarcoma, NOS 1 0 1 Malignant lymphoma, mixed small and large cell, diffuse 0 1 1 Mature T-cell lymphoma, NOS 0 1 1

C17.2 ILEUM 4 0 4 Adenocarcinoma in adenomatous polyp 1 0 1 Malignant lymphoma, NOS 1 0 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C17.9 SMALL INTESTINE, NOS 3 2 5 Leiomyosarcoma, NOS 2 0 2 Malignant lymphoma, mixed small and large cell, diffuse 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1 Follicular lymphoma, NOS 0 1 1

C18 COLON 264 235 499 C18.0 CECUM 28 18 46 No histological proof 0 2 2 Carcinoma, NOS 1 0 1 Adenocarcinoma, NOS 19 13 31 Adenocarcinoma in adenomatous polyposis coli 1 0 1 Mucinous adenocarcinoma 5 1 6 Mucin-producing adenocarcinoma 0 1 1 Signet ring cell carcinoma 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 2 0 2

C18.1 APPENDIX 1 2 3 Adenocarcinoma, NOS 1 2 3

C18.2 ASCENDING COLON 14 11 25 No histological proof 2 1 3 Carcinoma, NOS 0 1 1 Adenocarcinoma, NOS 12 9 21

C18.3 HEPATIC FLEXURE OF COLON 1 6 7 No histological proof 0 2 2 Adenocarcinoma, NOS 1 4 5

65 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C18.4 TRANSVERSE COLON 8 4 12 No histological proof 2 0 2 Adenocarcinoma, NOS 5 4 9 Mucinous adenocarcinoma 1 0 1

C18.5 SPLENIC FLEXURE OF COLON 3 3 6 Adenocarcinoma, NOS 3 3 6

C18.6 DESCENDING COLON 10 7 17 No histological proof 0 1 1 Adenocarcinoma, NOS 10 5 15 Mucin-producing adenocarcinoma 0 1 1

C18.7 SIGMOID COLON 69 62 131 No histological proof 6 3 9 Carcinoma, NOS 0 1 1 Adenocarcinoma, NOS 60 58 118 Adenocarcinoma in adenomatous polyp 2 0 2 Mucinous adenocarcinoma 1 0 1

C18.8 OVERLAPPING LESION OF COLON 1 0 1 Adenocarcinoma 1 0 1

C18.9 COLON, NOS 129 122 251 No histological proof 50 40 90 Carcinoma, undifferentiated, NOS 0 1 1 Adenocarcinoma, NOS 73 75 148 Adenocarcinoma in adenomatous polyposis coli 1 1 2 Carcinold tumor, NOS 1 0 1 Papillary adenocarcinoma, NOS 0 2 2 Mucinous adenocarcinoma 2 0 2 Signet ring cell carcinoma 1 2 3 Malignant lymphoma, NOS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1

C19 RECTOSIGMOID JUNCTION 10 11 21 C19.9 RECTOSIGMOID JUNCTION 10 11 21 Adenocarcinoma, NOS 10 11 21

66 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C20 RECTUM 144 98 242 C20.9 RECTUM, NOS 144 98 242 No histological proof 16 6 22 Carcinoma, undifferentiated, NOS 1 0 1 Carcinoma, anaplastic, NOS 1 0 1 Adenocarcinoma, NOS 116 87 203 Adenocarcinoma in adenomatous polyp 2 2 4 Neuroendocrine carcinoma, NOS 1 0 1 Papillary adenocarcinoma, NOS 1 0 1 Adenocarcinoma in villous adenoma 0 1 1 Adenocarcinoma in tubulovillous adenoma 1 0 1 Clear cell adenocarcinoma, NOS 0 1 1 Mucinous adenocarcinoma 2 0 2 Mucin-producing adenocarcinoma 1 0 1 Signet ring cell carcinoma 1 1 2 Leiomyosarcoma, NOS 1 0 1

C21 ANUS AND ANAL CANAL 4 4 8 C21.0 ANUS 3 2 5 Squamous cell carcinoma, NOS 2 1 3 Malignant melanoma, NOS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1

C21.1 ANAL CANAL 1 2 3 Adenocarcinoma, NOS 1 1 2 Adenosarcoma 0 1 1

C22 LIVER AND INTRAHEPATIC 558 183 741 BILE DUCTS C22.0 LIVER 504 153 657 No histological proof 407 122 529 Hepatocellular carcinoma, NOS 96 31 127 Hepatoblastoma 1 0 1

C22.1 INTRAHEPATIC BILE DUCT 54 30 84 No histological proof 23 18 41 Adenocarcinoma, NOS 15 6 21 Cholangiocarcinoma 15 6 21 Papillary adenocarcinoma, NOS 1 0 1 67 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C23 GALLBLADDER 10 15 25 C23.9 GALLBLADDER 10 15 25 No histological proof 4 6 10 Adenocarcinoma, NOS 5 7 12 Papillary adenocarcinoma, NOS 1 2 3

C24 EXTRAHEPATIC BILE DUCT 57 40 97 C24.0 EXTRAHEPATIC BILE DUCT 40 24 64 No histological proof 23 16 39 Carcinoma, NOS 1 1 2 Adenocarcinoma, NOS 14 6 20 Cholangiocarcinoma 1 1 2 Klatkin tumor 1 0 1

C24.1 AMPULLA OF VATER 11 10 21 No histological proof 5 0 5 Carcinoma, NOS 0 1 1 Carcinoma, undifferentiated, NOS 1 0 1 Adenocarcinoma, NOS 5 7 12 Cholangiocarcinoma, NOS 0 1 1 Papillary adenocarcinoma, NOS 0 1 1

C24.9 BILIARY TRACT, NOS 6 6 12 No histological proof 6 6 12

C25 PANCREAS 62 76 138 C25.0 HEAD OF PANCREAS 12 25 37 No histological proof 7 17 24 Carcinoma, NOS 1 0 1 Adenocarcinoma, NOS 4 6 12 Intraductal papillary-mucinous carcinoma, invasive 0 2 2

C25.1 BODY OF PANCREAS 1 1 2 No histological proof 0 1 1 Adenocarcinoma, NOS 1 0 1

C25.2 TAIL OF PANCREAS 1 2 3 No histological proof 0 1 1 Adenocarcinoma, NOS 0 1 1 Mucinous adenocarcinoma 1 0 1 68 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C25.3 PANCREATIC DUCT 0 1 1 Solid pseudopapillary carcinoma 0 1 1

C25.4 ISLETS OF LANGERHANS 0 1 1 Islet cell carcinoma 0 1 1

C25.8 OVETLAPPING LESION OF PANCREAS 0 1 1 No histological proof 0 1 1

C25.9 PANCREAS, NOS 48 45 93 No histological proof 34 29 63 Carcinoma, NOS 3 1 4 Adenocarcinoma, NOS 10 11 21 Papillary adenocarcinoma, NOS 1 0 1 Cystadenocarcinoma, NOS 0 1 1 Acinar cell carcinoma 0 1 1 Adenosquamous carcinoma 0 2 2

C26 ILL-DEFINED DIGESTIVE ORGANS 23 22 45 C26.0 INTESTINAL TRACT, NOS 16 12 28 No histological proof 15 12 27 Adenocarcinoma, NOS 1 0 1

C26.9 GASTROINTESTINAL TRACT, NOS 7 10 17 No histological proof 4 7 11 Carcinoma, NOS 0 1 1 Adenocarcinoma, NOS 3 2 5

C30 NASAL CAVITY AND MIDDLE EAR 13 13 26 C30.0 NASAL CAVITY 12 11 23 No histological proof 0 1 1 Carcinoma, undifferentiated, NOS 1 0 1 Squamous cell carcinoma, NOS 5 5 10 Squamous cell carcinoma large cell, nonkeratinizing, NOS 0 1 1 Schneiderian carcinoma 1 0 1 Adenocarcinoma, NOS 1 0 1 Adenoid cystic carcinoma, NOS 0 2 2 Mucoepidermoid carcinoma 1 0 1 Olfactory neurogenic tumor 0 1 1 69 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Malignant lymphoma, NOS 1 0 1 Malignant lymphoma, small B lymphocytic, NOS 1 0 1 Mature T-cell lymphoma, NOS 1 1 2

C30.1 MIDDLE EAR 1 2 3 Squamous cell carcinoma, NOS 1 2 3

C31 ACCESSORY SINUSES 16 5 21 C31.0 MAXILLARY SINUS 13 4 17 No histological proof 1 0 1 Carcinoma, NOS 1 0 1 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 6 2 8 Squamous cell carcinoma, keratinizing, NOS 1 0 1 Squamous cell carcinoma, small cell, nonkeratinizing, NOS 0 1 1 Adenoid cystic carcinoma 1 0 1 Mucoepidermoid carcinoma 2 0 2 Fibrosarcoma, NOS 1 0 1

C31.1 ETHMOID SINUS 1 0 1 Squamous cell carcinoma, NOS 1 0 1

C31.2 FRONTAL SINUS 0 1 1 Squamous cell carcinoma, NOS 0 1 1

C31.9 ACCESSORY SINUSES 2 0 2 No histological proof 1 0 1 Malignant lymphoma, NOS 1 0 1

C32 LARYNX 117 14 131 C32.0 GLOTTIS 37 4 41 No histological proof 1 0 1 Malignant tumor, giant cell type 1 0 1 Carcinoma, NOS 2 1 3 Squamous cell carcinoma, NOS 28 3 31 Squamous cell carcinoma, keratinizing, NOS 3 0 3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 1 0 1 Squamous cell carcinoma, spindle cell 1 0 1

70 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C32.1 SUPRAGLOTTIS 28 4 32 No histological proof 2 1 3 Carcinoma, undifferentiated, NOS 1 0 1 Squamous cell carcinoma, NOS 22 3 25 Squamous cell carcinoma, keratinizing, NOS 1 0 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 1 0 1 Malignant lymphoma, NOS 1 0 1

C32.8 OVERLAPPING LESION OF LARYNX 2 0 2 Squamous cell carcinoma, NOS 2 0 2

C32.9 LARYNX,NOS 50 6 56 No histological proof 9 2 11 Carcinoma, anaplastic, NOS 0 1 1 Squamous cell carcinoma, NOS 39 3 42 Squamous cell carcinoma, small cell nonkeratinizing, NOS 1 0 1 Papillary adenocarcinoma, NOS 1 0 1

C34 BRONCHUS AND LUNG 935 432 1367 C34.0 MAIN BRONCHUS 6 4 10 No histological proof 2 1 3 Squamous cell carcinoma 2 2 4 Adenocarcinoma, NOS 1 0 1 Adenoid cystic carcinoma 1 1 2

C34.1 UPPER LOBE, LUNG 82 29 111 No histological proof 20 8 28 Carcinoma, NOS 1 2 3 Large cell carcinoma , NOS 4 2 6 Carcinoma, undifferentiated, NOS 1 0 1 Giant cell carcinoma 1 0 1 Small cell carcinoma, NOS 3 1 4 Combined small cell carcinoma 2 0 2 Squamous cell carcinoma, NOS 27 2 29 Adenocarcinoma, NOS 17 9 26 Bronchiolo-alveolar adenocarcinoma, NOS 1 3 4 Mucinous adenocarcinoma 1 1 2 Adenosquamous carcinoma 4 1 5

71 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C34.2 MIDDLE LOBE, LUNG 4 4 8 No histological proof 1 3 4 Carcinoma, undifferentiated, NOS 1 0 1 Small cell carcinoma, NOS 1 0 1 Squamous cell carcinoma, NOS 1 0 1 Adenocarcinoma, NOS 0 1 1

C34.3 LOWER LOBE, LUNG 35 14 49 No histological proof 12 3 15 Carcinoma, NOS 4 0 4 Large cell carcinoma, NOS 1 0 1 Carcinoma, anaplastic, NOS 0 1 1 Oat cell carcinoma 1 0 1 Small cell carcinoma, fusiform cell 1 0 1 Combined small cell carcinoma 2 2 4 Squamous cell carcinoma, NOS 10 1 11 Adenocarcinoma, NOS 3 6 9 Bronchiolo-alveolar adenocarcinoma, NOS 0 1 1 Sarcoma, NOS 1 0 1

C34.8 OVERLAPPING LESION OF LUNG 3 1 4 Squamous cell carcinoma, NOS 1 0 1 Adenocarcinoma, NOS 2 1 3

C34.9 LUNG, NOS 805 380 1185 No histological proof 353 159 512 Carcinoma, NOS 60 50 110 Epithelioma, malignant 1 0 1 Large cell carcinoma, NOS 61 19 80 Carcinoma, undifferentiated, NOS 10 4 14 Carcinoma, anaplastic, NOS 3 3 6 Giant cell carcinoma 2 0 2 Small cell carcinoma, NOS 35 10 45 Combined small cell carcinoma 7 4 11 Non-small cell carcinoma 2 0 2 Papillary carcinoma, NOS 0 1 1 Squamous cell carcinoma 108 29 137 Squamous cell carcinoma large cell, nonkeratinizing, NOS 2 0 2 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Adenocarcinoma, NOS 135 86 221 72 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Adenoid cystic carcinoma, NOS 0 2 2 Neuroendocrine carcinoma, NOS 2 0 2 Bronchiolo-alveolar adenocarcinoma, NOS 4 10 14 Papillary adenocarcinoma, NOS 2 0 2 Mucinous adenocarcinoma 1 0 1 Mucin-producing adenocarcinoma 1 0 1 Adenosquamous carcinoma 16 2 18

C37 THYMUS 6 4 10 C37.9 THYMUS 6 4 10 No histological proof 0 1 1 Thymoma malignant, NOS 6 3 9

C38 HEART, MEDIASTINUM, AND PLEURA 2 1 3 C38.1 ANTERIOR MEDIASTINUM 0 1 1 No histological proof 0 1 1

C38.4 PLEURA 2 0 2 Mesothelioma, malignant 2 0 2

C40 LONG BONES AND JOINTS 7 6 13 C40.0 LONG BONES OF UPPER LIMB AND 1 0 1 ASSOCIATED JOINTS Chondrosarcoma, NOS 1 0 1

C40.2 LONG BONES OF LOWER LIMB AND 5 5 10 ASSOCIATED JOINTS No histological proof 2 2 4 Osteosarcoma, NOS 2 3 5 Chondroblastic osteosarcoma 1 0 1

C40.9 BONE OF LIMB, NOS 1 1 2 Osteosarcoma, NOS 0 1 1 Chondrosarcoma, NOS 1 0 1

C41 SHORT BONES AND JOINTS 9 8 17 C41.0 BONE OF SKULL AND FACE 3 1 4 Osteosarcoma, NOS 0 1 1 Chondroblastic osteosarcoma 1 0 1

73 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Chondrosarcoma, NOS 1 0 1 Mesenchymal chondrosarcoma 1 0 1

C41.1 MANDIBLE 1 0 1 No histological proof 1 0 1

C41.3 RIB, STERNUM, CLAVICLE AND 0 2 2 ASSOCIATED JOINTS Osteosarcoma, NOS 0 1 1 Chondrosarcoma, NOS 0 1 1

C41.4 PELVIC BONES, SACRUM, COCCYX AND 1 1 2 ASSOCIATED JOINTS No histological proof 1 1 2

C41.9 BONE, NOS 4 4 8 No histological proof 3 4 7 Osteosarcoma, NOS 1 0 1

C42 HEMATOPOIETIC SYSTEMS 217 208 425 C42.1 BONE MARROW 217 208 425 Multiple myeloma 18 28 46 leukemia, NOS 24 40 64 Acute leukemia, NOS 6 7 13 Lymphoid leukemia, NOS 13 8 21 B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma 4 3 7 Precursor cell lymphoblastic leukemia, NOS 39 32 71 Acute myeloid leukemia, M16 type 2 6 8 Myeloid leukemia, NOS 4 1 5 Acute myeloid leukemia, NOS 39 35 74 Chronic myeloid leukemia, NOS 27 15 42 Acute promyelocytic leukemia, t(15;17)(q22;q11-12) 2 0 2 Acute myelomonocytic leukemia 3 0 1 Acute basophilic leukemia 2 4 6 Acute monocytic leukemia 2 1 3 Acute megakaryoblastic leukemia 0 1 1 Hairy cell leukemia 0 1 1 Polycythemia vera 8 2 10 Chronic myeloproliferative disease, NOS 3 0 3 Myelosclerosis with myeloid metaplasia 3 1 4

74 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Essential thrombocythemia 5 7 12 Refractory anemia 0 5 5 Myelodysplastic syndrome, NOS 13 11 24

C44 SKIN 209 166 375 C44.0 SKIN OF LIP, NOS 5 6 11 Squamous cell carcinoma, NOS 1 2 3 Basal cell carcinoma, NOS 3 3 6 Basosquamous carcinoma 0 1 1 Malignant melanoma, NOS 1 0 1

C44.1 EYELID 4 8 12 No histological proof 0 1 1 Basal cell carcinoma, NOS 4 6 10 Sebaceous adenocarcinoma 0 1 1

C44.2 EXTERNAL EAR 21 8 29 No histological proof 1 0 1 Squamous cell carcinoma, NOS 8 3 11 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 1 1 Squamous cell carcinoma, small cell, nonkeratinizing 1 0 1 Basal cell carcinoma, NOS 8 4 12 Basosquamous carcinoma 1 0 1 Trabecular adenocarcinoma 1 0 1 Malignant melanoma, NOS 1 0 1

C44.3 SKIN OF FACE 51 73 124 No histological proof 0 1 1 Squamous cell carcinoma, NOS 9 12 21 Basal cell carcinoma, NOS 40 58 98 Skin appendage carcinoma 0 1 1 Dermatofibrosarcoma, NOS 2 0 2 Mycosis fungoides 0 1 1

C44.4 SKIN OF SCALP AND NECK 17 6 23 No histological proof 1 0 1 Squamous cell carcinoma, NOS 8 4 12 Squamous cell carcinoma, small cell, nonkeratinizing 1 0 1 Basal cell carcinoma, NOS 5 2 7 Dermatofibrosarcoma, NOS 2 0 2 75 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C44.5 SKIN OF TRUNK 40 15 55 Squamous cell carcinoma, NOS 18 6 24 Basal cell carcinoma, NOS 19 1 20 Basosquamous carcinoma 1 0 1 Skin appendage carcinoma 1 0 1 Malignant eccrine spiradenoma 1 0 1 Malignant melanoma, NOS 0 4 4 Dermatofibrosarcoma, NOS 0 4 4

C44.6 SKIN OF UPPER LIMB AND SHOULDER 18 12 30 Squamous cell carcinoma, NOS 8 4 12 Bowen disease 1 1 2 Basal cell carcinoma, NOS 6 3 9 Malignant melanoma, NOS 1 0 1 Amelantic melanoma 0 1 1 Dermatofibrosarcoma, NOS 1 3 4 Cutaneous T-cell lymphoma, NOS 1 0 1

C44.7 SKIN OF LOWER LIMB AND HIP 27 15 42 No histological proof 0 1 1 Carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 14 7 21 Basal cell carcinoma, NOS 3 1 4 Malignant melanoma, NOS 9 5 14 Spindle cell melanoma, NOS 1 0 1

C44.8 OVERLAPPING LESION OF SKIN 3 1 4 Squamous cell carcinoma, NOS 1 1 2 Basal cell carcinoma, NOS 2 0 2

C44.9 SKIN, NOS 23 23 46 No histological proof 2 0 2 Verrucous carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 7 8 15 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 1 0 1 Basal cell carcinoma, NOS 6 8 14 Sebaceous adencarcinoma 1 0 1 Malignant melanoma, NOS 6 5 11 76

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C47 PERIPHERAL NERVES 4 5 9 C47.4 PERIPHERAL NERVES AND AUTONOMIC NERVOUS 2 0 2 SYSTEM OF ABDOMEN Neuroblastoma, NOS 2 0 2

C47.8 OVERLAPPING LESION OF PERIPHERAL NERVES 0 1 1 AND AUTONOMIC NERVOUS SYSTEM Neuroblastoma, NOS 0 1 1

C47.9 AUTONOMIC NERVOUS SYSTEM, NOS 3 4 7 Neuroblastoma, NOS 1 2 3 Malignant peripheral nerve sheath tumor 1 0 1 Neurilemoma, malignant 0 2 2 Malignant peripheral nerve sheath tumor with rhabdomyoblastic 1 0 1 differentiantion

C48 RETROPERITONEUM AND 1 0 1 PERITONEUM C48.0 RETROPERITONEUM 1 0 1 Malignant tumor, spindle cell type 1 0 1

C49 CONNECTIVE, SUBCUTANEOUS AND 37 31 68 OTHER SOFT TISSUES C49.0 CONNECTIVE, SUBCUTANEOUS AND OTHER 7 3 10 SOFE TISSUES OF HEAD, FACE AND NECK Fibrosarcoma, NOS 1 0 1 Malignant fibrous histiocytoma 2 1 3 Liposarcoma, NOS 2 1 3 Myxoid liposarcoma 1 0 1 Embryonal rhabdomyosarcoma, NOS 1 1 2

C49.1 CONNECTIVE,SUBCUTANEOUS AND OTHER 4 2 6 SOFT TISSUES OF UPPER LIMB AND SHOULDER Spindle cell sarcoma 1 0 1 Malignant fibrous histiocytoma 1 0 1 Liposarcoma, NOS 1 0 1 Myxoid liposarcoma 1 0 1 Leiomyosarcoma, NOS 1 1 2 Kaposi sarcoma 0 1 1

Reults : Pathology

Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C49.2 CONNECTIVE, SUBCUTANEOUS AND OTHER 9 11 20 SOFT TISSUES OF LOWER LIMB AND HIP Sarcoma, NOS 1 0 1 Spindle cell sarcoma 1 2 3 Malignant fibrous histiocytoma 3 4 7 Liposarcoma, NOS 1 1 2 Myxoid liposarcoma 0 2 2 Myxed liposarcoma 0 1 1 Leiomyosarcoma, NOS 0 1 1 Synovial sarcoma, NOS 2 0 2 Kaposi sarcoma 1 0 1

C49.3 CONNECTIVE, SUBCUTANEOUS AND OTHER 1 2 3 SOFT TISSUES OF THORAX Sarcoma, NOS 0 1 1 Spindle cell sarcoma 0 1 1 Malignant fibrous histiocytoma 1 0 1

C49.4 CONNECTIVE, SUBCUTANEOUS AND OTHER 2 5 7 SOFT TISSUES OF ABDOMEN Sarcoma, NOS 0 2 2 Spindle cell sarcoma 1 0 1 Malignant fibrous histiocytoma 0 1 1 Liposarcoma, NOS 0 1 1 Leiomyosarcoma, NOS 0 1 1 Kaposi sarcoma 1 0 1

C49.5 CONNECTIVE, SUBCUTANEOUS AND OTHER 3 0 3 SOFT TISSUES OF PELVIS Malignant fibrous histiocytoma 2 0 2 Leiomyosarcoma, NOS 1 0 1

C49.6 CONNECTIVE, SUBCUTANEOUS AND OTHER 3 0 3 SOFT TISSUES OF TRUNK, NOS Sarcoma, NOS 1 0 1 Liposarcoma, NOS 1 0 1 Clear cell sarcoma, NOS 1 0 1

78 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C49.9 CONNECTIVE, SUBCUTANEOUS AND OTHER 8 8 16 SOFT TISSUES, NOS Sarcoma, NOS 3 1 4 Malignant fibrous histiocytoma 0 1 1 Liposarcoma, NOS 0 1 1 Myxoid liposarcoma 0 1 1 Leiomyosarcoma, NOS 0 1 1 Rhabdomyosarcoma, NOS 1 1 2 Malignant rhabdoid tumor 1 1 2 Kaposi sarcoma 1 0 1 Hemangiopericytoma, malignant 1 1 2 Chordoma, NOS 1 0 1

C50 BREAST 7 1079 1086 C50.0 NIPPLE 0 4 4 Infiltrating duct carcinoma, NOS 0 3 3 Paget disease, mammary 0 1 1

C50.1 CENTRAL PORTION OF BREAST 0 15 15 No histological proof 0 1 1 Papillary carcinoma, NOS 0 2 2 Mucinous adenocarcinoma 0 2 2 Infiltrating duct carcinoma, NOS 0 9 9 Paget disease, mammary 0 1 1

C50.2 UPPER-INNER QUADRANT OF BREAST 0 47 47 Carcoma, NOS 0 2 2 Pseudosarcomatous carcinoma 0 1 1 Mucinous adenocarcinoma 0 1 1 Infiltrating duct carcinoma, NOS 0 40 40 Lobular carcinoma, NOS 0 2 2 Infiltrating duct and lobular carcinoma 0 1 1

C50.3 LOWER-INNER QUADRANT OF BREAST 0 11 11 Infiltrating duct carcinoma, NOS 0 10 10 Infiltrating duct and lobular carcinoma 0 1 1

C50.4 UPPER-OUTER QUADRANT OF BREAST 0 116 116 No histological proof 0 1 1 Adenocarcinoma, NOS 0 1 1

79 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Tubular adenocarcinoma 0 1 1 Mucinous adenocarcinoma 0 4 4 Infiltrating duct carcinoma, NOS 0 104 104 Intraductal papillary adenocarcinoma with invasion 0 2 2 Lobular carcinoma, NOS 0 2 2 Infiltrating duct and lobular carcinoma 0 1 1

C50.5 LOWER-OUTER QUADRANT OF BREAST 0 19 19 Adenocarcinoma, NOS 0 1 1 Infiltrating duct carcinoma, NOS 0 15 15 Medullary carcinoma, NOS 0 1 1 Lobular carcinoma, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1

C50.6 AXILLARY TAIL OF BREAST 0 1 1 Infiltrating duct carcinoma, NOS 0 1 1

C50.8 OVERLAPPING LESION OF BREAST 1 66 67 No histological proof 0 2 2 Mucinous adenocarcinoma 0 2 2 Infiltrating duct carcinoma, NOS 1 56 57 Lobular carcinoma, NOS 0 2 2 Infiltrating ductular carcinoma 0 1 1 Infiltrating duct and lobular carcinoma 0 2 1 Phyllodes tumor, malignant 0 1 1

C50.9 BREAST, NOS 6 800 806 No histological proof 2 102 104 Carcinoma, NOS 0 17 17 Pseudosarcomatous carcinoma 0 1 1 Papillary carcinoma, NOS 0 2 2 Adenocarcinoma, NOS 0 9 9 Tubular adenocarcinoma 0 1 1 Papillary adenocarcinoma 0 1 1 Mucinous adenocarcinoma 1 11 12 Infiltrating duct carcinoma, NOS 2 614 616 Medullary carcinoma, NOS 0 5 5 Lobular carcinoma, NOS 1 22 23 Infiltrating ductular carcinoma 0 1 1 80 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Infiltrating duct and lobular carcinoma 0 8 8 Paget disease and infiltrating duct carcinoma of breast 0 2 2 Phyllodes tumor, malignant 0 4 4

C51 VULVA 0 15 15 C51.0 LABIA MAJOS 0 1 1 Squamous cell carcinoma 0 1 1

C51.9 LABIA MINORA 0 14 14 No histological proof 0 1 1 Verrucous papilloma 0 1 1 Squamous cell carcinoma, NOS 0 7 7 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 1 1 Basal cell carcinoma, NOS 0 1 1 malignant melanoma, NOS 0 1 1 Peripheral neuroectodermal tumor 0 1 1

C52 VAGINA 0 6 6 C52.9 VAGINA, NOS 0 14 14 No histological proof 0 1 1 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 3 3 Papillary adenocarcinoma, NOS 0 1 1

C53 CERVIX UTERI 0 866 866 C53.0 ENDOCERVIX 0 22 22 Squamous cell carcinoma, NOS 0 2 2 Squamous cell carcinoma, keratinizing, NOS 0 2 2 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 3 3 Adenocarcinoma, NOS 0 8 8 Papillary adenocarcinoma, NOS 0 1 1 Mixed cell adenocarcinoma, NOS 0 1 1 Endometrioid adenocarcinoma, NOS 0 1 1 Endometrioid adenofibroma, malignant 0 1 1 Adenocarcinoma, endocervical type 0 1 1 Adenosquamous carcinoma 0 2 2

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C53.8 OVERLAPPING LESION OF CERVIX UTERI 0 2 2 Squamous cell carcinoma, keratinizing, NOS 0 1 1 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 1 1

C53.9 CERVIX UTERI 0 842 842 No histological proof 0 120 120 Carcinoma, NOS 0 5 5 Carcinoma, undifferentiated, NOS 0 1 1 Carcinoma, anaplastic, NOS 0 1 1 Papillary squamous cell carcinoma 0 6 6 Squamous cell carcinoma, NOS 0 225 225 Squamous cell carcinoma, keratinizing, NOS 0 88 88 Squamous cell carcinoma, large cell, nonkeratinizing, NOS 0 235 235 Squamous cell carcinoma, small cell nonkeratinizing 0 13 13 Squamous cell carcinoma, microinvasive 0 24 24 Adenocarcinoma, NOS 0 65 65 Papillary adenocarcinoma, NOS 0 13 13 Villous adenocarcinoma 0 1 1 Clear cell adenocarcinoma, NOS 0 1 1 Endometrioid adenofibroma, malignant 0 1 1 Mucinous adenocarcinoma 0 7 7 Mucin-producing adenocarcinoma 0 1 1 Signet ring cell carcinoma 0 2 2 Adenosquamous carcinoma 0 31 31 Sarcoma, NOS 0 1 1 Leiomyosarcoma, NOS 0 1 1

C54 CORPUS UTERI 0 159 159 C54.0 ISTHMUS UTERI 0 2 2 Adenocarcinoma 0 1 1 Endometrioid adenocarcinoma, NOS 0 1 1

C54.1 ISTHMUS UTERI 0 138 138 No histological proof 0 8 8 Carcinoma, NOS 0 2 2 Adenocarcinoma, NOS 0 60 60 Papillary adenocarcinoma, NOS 0 6 6 Clear cell adenocarcinoma, NOS 0 1 1 Mixed cell adenocarcinoma, NOS 0 1 1 Endometrioid adenocarcinoma, NOS 0 39 39 82 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Mucinous adenocarcinoma 0 1 1 Adenosquamous carcinoma 0 3 3 Adenocarcinoma with squamous metaplasia adenoacanthoma 0 3 3 Endometrial stromal sarcoma, NOS 0 4 4 Endometrial stromal sarcoma, low grade 0 1 1 Mullerian mixed tumor 0 9 9

C54.2 MYOMETRIUM 0 9 9 Leiomyosarcoma, NOS 0 8 8 Carcinosarcoma, NOS 0 1 1

C54.9 CORPUS UTERI 0 10 10 No histological proof 0 3 3 Carcinoma, undifferentiated, NOS 0 1 1 Adenocarcinoma, NOS 0 3 3 Endometrioid adenocarcinoma, NOS 0 1 1 Mullerian mixed tumor 0 2 2

C56 OVARY 0 203 203 C56.9 OVARY 0 203 203 No histological proof 0 44 44 Carcinoma, NOS 0 9 9 Carcinoma, undifferentiated, NOS 0 1 1 Small cell carcinoma, NOS 0 1 1 Papillary carcinoma, NOS 0 1 1 Squamous cell carcinoma, NOS 0 3 3 Adenocarcinoma, NOS 0 15 15 Neuroendocrine carcinoma, NOS 0 1 1 Papillary adenocarcinoma, NOS 0 4 4 Clear cell adenocarcinoma, NOS 0 18 18 Endometrioid adenocarcinoma, NOS 0 19 19 Cystadenocarcinoma, NOS 0 1 1 Serous cystadenocarcinoma, NOS 0 9 9 Papillary serous cystadenocarcinoma 0 19 19 Mucinous cystadenocarcinoma,NOS 0 17 17 Papillary mucinous cystadenocarcinoma, NOS 0 1 1 Mucinous adenocarcinoma 0 16 16 Mucin-producing adenocarcinoma 0 1 1 Signet ring cell carcinoma 0 1 1 Granulosa cell tumor, malignant 0 2 2 83 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

Brenner tumor, malignant 0 4 4 Dysgerminoma 0 6 6 Germinoma 0 1 1 Embryonal carcinoma, NOS 0 1 1 Yolk sac tumor 0 2 2 Teratoma, malignant, NOS 0 3 3 Teratoma with malignant transformation 0 1 1 Mixed germ cell tumor 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1

C57 OTHER AND USPECIFIED FEMALE 0 2 2 GENITAL ORGANS C57.0 FALLOPIAN TUBE 0 2 2 Papillary adenocarcinoma, NOS 0 1 1 Adenocarcinoma, NOS 0 1 1

C58 PLACENTA 0 14 14 C58.9 PLACENTA 0 14 14 Choriocarcinoma, NOS 0 14 14

C60 PENIS 31 0 31 C60.0 PREPUCE 1 0 1 Squamous cell carcinoma, NOS 1 0 1

C60.1 GLANS PENIS 3 0 3 Squamous cell carcinoma, keratinizing, NOS 3 0 3

C60.9 PENIS, NOS 27 0 27 No histological proof 7 0 7 Squamous cell carcinoma, NOS 20 0 20

C61 PROSTATE GLAND 212 0 212 C61.9 PROSTATE GLAND 212 0 212 No histological proof 62 0 62 Carcinoma, NOS 2 0 2 Adenocarcinoma, NOS 147 0 147 Sarcoma, NOS 1 0 1

84 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C62 TESTIS 41 0 41 C62.0 UNDESENDED TESTIS 2 0 2 Seminoma, NOS 1 0 1 Germinoma 1 0 1

C62.9 TESTIS, NOS 39 0 39 No histological proof 1 0 1 Squamous cell carcinoma, NOS 2 0 2 Malignant fibrous histiocytoma 1 0 1 Seminoma, NOS 16 0 16 Germinoma 8 0 8 Yolk sac tumor 1 0 1 Teratoma, malignant, NOS 4 0 4 Mixed germ cell tumor 3 0 3 Malignant lymphoma, non-Hodgkin, NOS 1 0 1 Malignant lymphoma, mixed small and large cell, diffuse 1 0 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C64 KIDNEY 24 15 39 C64 .9 KIDNEY 24 15 39 No histological proof 6 4 10 Carcinoma, NOS 1 1 2 Adenocarcinoma, NOS 2 0 2 Solid carcinoma, NOS 1 0 1 Clear cell adenocarcinoma, NOS 2 1 3 Renal cell carcinoma, NOS 9 7 16 Nephoblastoma, NOS 3 2 5

C65 RENAL PELVIS 5 6 11 C65.9 RENAL PELVIS 5 6 11 No histological proof 1 1 2 Transitional cell carcinoma, NOS 4 4 8 Adenocarcinoma, NOS 0 1 1

C66 URETER 1 4 5 C66.9 URETER 1 4 5 Transitional cell carcinoma, NOS 1 4 5

C67 BLADDER 153 31 184 C67.0 TRIGONE OF BLADDER 1 0 1 Papillary transitional cell carcinoma 1 0 1

85 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C67.2 LATERAL WALL OF BLADDER 1 0 1 No histological proof 1 0 1

C67.3 ANTERIOR WALL OF BLADDER 2 0 2 Papillary transitional cell carcinoma 1 0 1 Embryonal rhabdomyosarcoma, NOS 1 0 1

C67.4 POSTERIOR WALL OF BLADDER 1 0 1 Transitional cell carcinoma, NOS 1 0 1

C67.9 BLADDER, NOS 148 31 179 No histological proof 31 6 37 Squamous cell carcinoma, NOS 1 2 3 Transitional cell carcinoma, NOS 94 15 109 Papillary transitional cell carcinoma 21 5 26 Adenocarcinoma, NOS 1 0 1 Papillary adenocarcinoma, NOS 0 1 1 Carcinosarcoma, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 0 1 1

C68 UNSPECIFIED URINARY ORGANS 1 1 2 C68.0 URETHRA 1 1 2 No histological proof 1 0 1 Transitional cell carcinoma, NOS 0 1 1

C69 EYE AND ADNEXA 10 7 17 C69.0 CONJUNCTIVA 2 5 7 No histological proof 0 1 1 Squamous cell carcinoma, NOS 2 4 6

C69.1 CORNEA 1 0 1 Squamous cell carcinoma, NOS 1 0 1

C69.2 RETINA 2 0 2 Retinoblastoma, NOS 2 0 2

C69.3 CHOROID 1 0 1 Malignant melanoma, NOS 1 0 1

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C69.5 LACRIMAL GLAND 2 1 3 Mucoepidermoid carcinoma 1 1 2 Mixed tumor, malignant, NOS 1 0 1

C69.6 ORBIT, NOS 1 0 1 Malignant lymphoma, non-Hodgkin, NOS 1 0 1

C69.9 EYE, NOS 1 1 2 Carcinoma, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C70 MENINGES 1 2 3 C70.9 MENINGES, NOS 1 2 3 Meningioma, malignant 1 1 2 Papillary meningioma 0 1 1

C71 BRAIN 74 58 132 C71.1 FRONTAL LOBE 4 5 9 Mixed glioma 0 1 1 Astrocytoma, NOS 2 1 3 Astrocytoma, anaplastic 1 0 1 Glioblastoma, NOS 1 1 2 Oligodendroglioma, NOS 0 2 2

C71.2 TEMPORAL LOBE 3 4 7 No histological proof 1 0 1 Mixed glioma 0 1 1 Ependymoma, NOS 1 1 2 Astrocytoma, NOS 0 1 1 Glioma, malignant 1 1 2

C71.3 PARIETAL LOBE 1 1 2 No histological proof 1 0 1 Ependymoma, NOS 0 1 1

C71.4 OCCIPITAL LOBE 3 1 4 No histological proof 0 1 1 Astrocytoma, NOS 1 0 1 Astrocytoma, anaplastic 1 0 1 Glioblastoma, NOS 1 0 1 87 Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Pathology And Sites Male Female Total

C71.5 VENTRICLE, NOS 1 2 3 Ependymoma, NOS 1 0 1 Astrocytoma, NOS 0 1 1 Gemistocytic astrocytoma 0 1 1

C71.6 CEREBELLUM, NOS 6 0 6 Hemangiopericytoma, malignant 1 0 1 Astrocytoma, NOS 2 0 2 Medulloblastoma, NOS 3 0 3

C71.7 BRAIN STEM 1 2 3 No histological proof 1 1 2 Glioma, malignant 0 1 1

C71.8 OVERLAPPING LESION OF BRAIN 0 2 2 Glioblastoma, NOS 0 2 2

C71.9 BRAIN, NOS 55 41 96 No histological proof 32 27 59 Glioma, malignant 4 0 4 Astrocytoma, NOS 10 6 16 Astrocytoma, anaplastic 1 0 1 Glioblastoma, NOS 5 4 9 Gliosarcoma 0 1 1 Oligodendroglioma, NOS 2 3 5 Primitive neuroectodermal tumor, NOS 1 0 1

C73 THYROID GLAND 37 186 223 C73.9 THYROID GLAND 37 186 223 No histological proof 6 16 22 Carcinoma, NOS 5 3 8 Carcinoma, undifferentiated, NOS 1 2 3 Carcinoma, anaplastic, NOS 3 3 6 Giant cell and spindle cell carcinoma 0 1 1 Squamous cell carcinoma, NOS 0 2 2 Adenocarcinoma in adenomatous polyp 1 0 1 Neuroendocrine carcinoma, NOS 0 1 1 Papillary carcinoma, NOS 14 119 133 Oxyphilic adenocarcinoma 0 2 2 88

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-207

Pathology And Sites Male Female Total

Follicular adenocarcinoma, NOS 4 27 31 Papillary carcinoma, follicular variant 3 9 12 Medullary carcinoma, NOS 0 1 1

C74 ADRENAL GLAND 2 3 5 C74.0 CORTEX OF ADRENAL GLAND 0 2 2 Adenocarcinoma 0 1 1 Adrenal cortical carcinoa, NOS 0 1 1

C74.1 MEDULLA OF ADRENAL GLAND 2 0 2 Pheochromocytoma, NOS 1 0 1 Neuroblastoma, NOS 1 0 1

C74.9 ADRENAL GLAND, NOS 0 1 1 No histological proof 0 1 1

C75 OTHER ENDOCRINE GLANDS 1 2 3 C75.0 PARATHYROID GLAND 0 1 1 Carcinoma, NOS 0 1 1

C75.1 PITUITARY GLAND 1 1 2 No histological proof 1 0 1 Chromophobe carcinoma 0 1 1

C77 LYMPH NODES 145 132 277 C77.0 LYMPH NODES OF HEAD, FACE AND NECK 45 41 86 Malignant lymphoma, NOS 17 8 25 Malignant lymphoma, non-Hodgkin, NOS 5 6 11 Hodgkin lymphoma, NOS 4 5 9 Hodgkin lymphoma, mixed cellularity, NOS 1 1 2 Hodgkin lymphoma, Mixed small and large, diffuse 5 2 7 Malignant lymphoma, large B-cell, lymphocytic, NOS 11 15 26 Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS 0 1 1 Burkitt lymphoma, NOS 1 0 1 Follicular lymphoma, NOS 0 1 1 Mature T-cell lymphoma, NOS 0 2 2 Mast cell sarcoma 1 0 1

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

C77.1 INTRATHORACIC LYMPH NODES 2 3 5 Malignant lymphoma, NOS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 0 1 1 Hodgkin lymphoma, nodular sclerosis, NOS 2 1 3

C77.2 INTRA-ABDOMINAL LYMPH NODES 3 8 11 Malignant lymphoma, NOS 1 4 5 Malignant lymphoma, non-Hodgkin, NOS 2 0 2 Hodgkin lymphoma, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 0 3 3

C77.3 LYMPH NODES OF AXILLA OR ARM 12 4 16 Malignant lymphoma 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 1 1 2 Hodgkin lymphoma, NOS 1 0 1 Hodgkin lymphoma, nodular sclerosis, NOS 1 0 1 Malignant lymphoma, small B lymphocytic, NOS 2 0 2 Malignant lymphoma, large B-cell, diffuse, NOS 6 2 8 Anaplastic large cell lymphoma, T cell and Null cell type 1 0 1

C77.4 LYMPH NODES OF INGUINAL REGION OR LEG 6 4 10 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1 Hodgkin lymphoma, NOS 1 1 2 Hodgkin lymphoma, Mixed small and large, diffuse 1 0 1 Malignant lymphoma, large B-cell diffuse, NOS 3 2 5 Anaplastic large cell lymphoma, T cell and Null cell type 0 1 1

C77.5 PELVIC LYMPH NODES 2 3 5 Malignant lymphoma, NOS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 1 1 2 Malignant lymphoma, small B lymphocytic, NOS 0 1 1 Malignant lymphoma, large B-cell, diffuse, NOS 1 0 1

C77.8 LYMPH NODES OF MULTIPLE REGIONS 0 1 1 Malignant lymphoma, non-Hodgkin, NOS 0 1 1

C77.9 LYMPH NODES, NOS 75 68 143 Malignant lymphoma, NOS 38 29 67 Malignant lymphoma, non-Hodgkin, NOS 9 10 19 Hodgkin lymphoma, NOS 4 1 5 Malignant lymphoma, small B lymphocytic, NOS 2 1 3 Malignant lymphoma, lymphoplasmacytic 1 0 1

Reults : Pathology Cancer Incidence and Mortality in Chonburi, 2003-2007

Malignant lymphoma, mixed small and large cell, diffuse 3 0 3 Malignant lymphoma, large B-cell, diffuse, NOS 12 21 33 Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS 1 2 3 Follicular lymphoma, NOS 0 1 1 Follicular lymphoma, grade 3 0 1 1 Mature T-cell lymphoma, NOS 4 2 6 Anaplastic large cell lymphoma, T cell and Null cell type 1 0 1

C80 UNKNOWN PRIMARY SITE 154 114 268 C80.9 UNKNOWN PRIMARY SITE 154 114 268 No histological proof 118 87 205 Carcinoma, NOS 8 8 16 Carcinoma, undifferentiated, NOS 3 0 3 Squamous cell carcinoma, NOS 14 3 17 Squamous cell carcinoma, keratinizing, NOS 0 2 2 Squamous cell carcinoma, small cell, nonkeratinizing 1 0 1 Adenocarcinoma, NOS 10 13 23 Papillary adenocarcinoma, NOS 0 1 1

commemt : 1. Number of new cancer cases by sites and sexes is not the same as in the table 1-4 (in the Appendex A) due to lymphoma in the organ should be included in the lymphoma group.

2. 32 cases in male and 27 cases in female in Hematopoietic system (new coding in third edition of ICD-O)are not included in the table data analysis.

3. 260 cases of carcinoma in situ are not included in the analysis.

Referemces cancer

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

REFERENCES Deerasamee, S., Martin, N., Bernard, W.,Stewart, PK. (2003) World Sriamporn, S., Sriprang, H., Cancer Report WHO, International Srivatanakul, P., Vatasapt, V., Parkin, Agency for Research on Cancer, D.M., and Feraly, J. (1999) Cancer in IARC Press, Lyon, France. Thailand 1992-1994 (IARC Technical Report No.34), Oliver, H.B., Donald, E.N., Robert, V.P. Lyon, IARC. Hutter, Kennedy, B.J., (1993) Fritz, A., Percy, C., Jack, A., Handbook for Staging of Cancer, Shanmugaratnam, K., Sobin, L., Fourth Edition, American Joint Parkin, D.M., and Whelan, S., (2000) Committee on Cancer TNM International Classification of Committee of International Union Diseases for Oncology, Third Agianst Cancer, J.B. Lippincott Edition, Geneva, WHO. Company, Philadephia. Jensen, O.M., Parkin, D.M., Maclennan, R., Parkin, D.M., Muir, C.S.,Whelan, S.L., Gao, Muir, C.S., and Skeet, R.G., (1991) Y.T., Ferlay J.,and Powell, J. (1991) Cancer Registration Principles and Cancer Incidence in Five Continents, Methods (IARC Scientific Vol.VI (IARC Scientific Publications Publications No 95), Lyon, France. No.120) International Agency of Kanka, C., and Sontipong, S., (2007) Cancer Research on Cancer, Lyon, France, in Lopburi Vol.I, 1998-2002 Cancer pp.542-549. registry unit, Lopburi, Thailand. Parkin, D.M., Whelan, S.L., Ferlay J., Khuhaprema, T., Srivatanakul, P., Sriplung, Raymond, R., and Young, J. (1997) H., Wiangnon, S., Sumitsawan, Y., Cancer Incidence in Five Continents, Attasara, P., (2007) Cancer in Vol.VII (IARC Scientific Publications Thailand Vol.IV, 1998-2000, No.155) International Agency of Bangkok, Thailand. Research on Cancer, Lyon, France, Martin, N., Lorvidhaya, V., Changwaiwit, pp.296-305. W. (1989) Cancer Incidence and Parkin, D.M., Whelan, S.L., Ferlay J., Mortality 1983-1987 in Chiang Mai Teppo, L., and Thomas, D.B., (2002) Province, Chiang Mai University Cancer Incidence in Five Continents, Hospital, Faculty of Medicine, Chiang Vol.VIII (IARC Scientific Mai, Thailand. Publications No.155) International Martin, N., Sontipong, S., Chindavijak, K., Agency of Research on Cancer, Lyon, Voottiprux, V., Deerasamee, S.,(2001) France, pp.434-441. Cancer incidence in Bangkok 1993- Percy, C., Holter, V. and Muir, C., (1990) 1997, National Cancer Institute, International Classification of Disease Department of Medical Services, for Oncology Second Edition,Geneva, Ministry of Public Health, Bangkok, WHO. Thailand. Pongnikorn, S., Martin, N., Patel, N., (2002) Martin, N., Srisukho, S., Kunpradist, O., Cancer Incidence in Lampang Vol.II Suttajit, M., (1998) Survival from 1993-1997, Lampang, Thailand. cancer in Chiang Mai, Thailand. In: Pongnikorn, S., Martin, N., Patel, N., Sankaranayanan, R., Black, R.J., and Daoprasert K., (2003) Cancer Parkin, D.M. eds, Cancer survival in Mortality in Lampang 1990-2000, Lampang, Thailand. Pongnikorn, S., Martin, N., Developing Countries (IARC. Pornruangwong, W., Daoprasert, K., Scientific Publication No.145) Lyon, (2004) Cancer Incidence and Mortality IARC. in Lampang,

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Vol.III 1998-2002, Lampang, Thailand. Chonburi,Thailand Vol. I, 1998-2002, Pongnikorn, S., Martin, N., Chonburi, Thailand. Pornruangwong, W., Ruanroadrung, The 1980. population and hosing census of N., Daoprasert, K., (2005) Cancer changwat Chonburi 1981 , National Survival in Lampang, 1993-2002, Statistical Office, office of the Prime Lampang, Thailand. minister. Pongnikorn, S., Martin, N., Raunroadroong, The 1990 population and hosing census of N., Kamoltbum, T., Boonyawattana, changwat Chonburi 1991 , National V., Sangnark, B., and Daoprasert, K., Statistical Office, office of the Prime (2006) Cancer Incidence in minister. Phitsanulok Vol.I 1998-2002 The 2000 population and hosing census of Lampang, Thailand. changwat Chonburi 2001 , National Pongnikorn, S., Martin, N., Pornimit, C., Statistical Office, office of the Prime Kullkonkarn, C., Matanasarawut, W., minister. Daoprasert, K., and Cholphon, A., Vatanasapt,V., Martin, N., Sriplung, H., (2006) Cancer in Lamphun, Vol. I Chindavijak, K., Sontipong, S., 1998-2002, Lampang, Thailand. Sriamporn, S., Parkin, D.M., Ferlay, J., Spiessel, B., Hermanele, P., Scheibe, O., (1993) Cancer in Thailand 1988-1991, Wagner, G., (1982) International IARC Union Against Cancer, UICC (Union Vatanasapt, V., Sriamporn, S., Kamsaad, S., International Centre le Cancer). Suwanrungruang, K., Pengsaa, P., Sriplung, H., Sontipong, S., Martin, N., Charoensiri, D.J., Chiyakum, J., Wiangnon, S., Vootiprux, V., Pesee, M (1998) Survival from cancer Cheirsilpa, A., Kanchanabat. C., in Khon Kaen, Thailand. In: Khuhaprema, T., (2003) Cancer in Sankaranayanan, R., Black, R.J., and Thailand Vol. III, 1995-1997, Parkin, D.M. eds, Cancer survival in Bangkok, Thailand. Developing Countries (IARC. Srivatanakul, P., Martin, N., Ratanavikrant, Scientific Publication No.145) Lyon, R., (1994) cancer in Lampang 1988- IARC. 1992, Bangkok. Zhu, Y.R., Chen, J.G.,& Huang, Sumitsawan, Y., Srisukho, S. Chiang Mai X.Y.,(1989) Hepatocellular Cancer Registry in Sriplung, H., Carcinoma in Qudong Sontipong, S., Martin, N., Wiangnon, Country.In:Tang, Z.Y., Wu, M.C., & S., Vootiprux, V., Cheirsilpa, A., Xia, S.S., eds; Primary liver cancer. Kanchanabat. C., Khuhaprema, T., Beijing, China Academic (2003) Cancer in Thailand Vol. III, Publishers/Springer-Verlog, 202-221. 1995-1997, Bangkok, Thailand. Thepsuwan, K., Martin, N., Watana, S., Pattatang, A., Pongpanich, K., (2007) Cancer incidence and Maotality in

Appendix A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

APPENDIX A

The number of new cancer cases and an average of age – standardized incidence rates of Five-year period (1998-2002, 2003-2007) are shown in table 1-8 of this Appendix.

This report contains the age-specific incidence rates, crude incidence rates and age-standardized incidence rates of new cancer can each year from 2003- 2007 (Table 9-18).

In this study, we present on the actual data of cancer deaths by sex, site, mortality of all cancer types and the number of cancer during the year 1998-2002 and 2003- 2007 (Five-year period) in table 19-26.

Population pyramids of Chonburi in 1980, 1990, 2000 (Census) and 2005 are shown in figure 1-4 of this Appendix.

Appendix A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 1 Population Pyramid of Chonburi, 1980 (Census)

Figure 2 Population Pyramid of Chonburi, 1990 (Census)

Appendix A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3 Population Pyramid of Chonburi, 2000 (Census)

Figure 4 Population Pyramid of Chonburi, 2005

96 Appendix A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 5 Leading cancers in Chonburi, 2003-2007

Male

Lung 37.9

Liver 20.9

Colorectal 15.9

Prostate 8.8

Oral Cavity 8.5

Skin 8.4 Cancer SiteCancer

Leukemia 6.5

Lymphoma 6.2

Esophagus 6.1

Bladder 6.1

0 5 10 15 20 25 30 35 40

ASR

Female

Breast 31.5 Cervix 25.8

Lung 14.5 Colorectal 11.2 Ovary 6.2 Liver 5.9

Cancer SiteCancer Skin 5.5 Thyroid 5.5 Leukemia 5.4 Corpus 5.1 Lymphoma 5.1

0 5 10 15 20 25 30 35 40

ASR

Appendix A

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 6 Leading cancers of new cases 1998-2002, after update

Male

Lung 31 Liver 18.5 Colorectal 12.7 Oral Cavity 7.2 Bladder 6.9 Prostate 5.9 Cencer SiteCencer Esophagus 5.1 Lymphoma 5.1 Leukamia 4.9 Skin 4.7

0 5 10 15 20 25 30 35

ASR

Female

Cervix 30.1

Breast 24.2

Lung 10.5

Colorectal 9.1

Liver 6.6

Ovary 6.1 Cancer SiteCancer Oral Cavity 4.4

Corpus 4.3

Leukemia 4

Thyroid 3.9

0 5 10 15 20 25 30 35 ASR

100

101

102

103

104

105

106

107

108 109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

APPENDIX B

These monographs focus on the actual data of cancer incidence by sex, site of all Cancer type are included the number of cancers age-specific incidence rates, crude incidence rates and age-standardized rates (ASR) during 2003-2009 five- year period by district of Chonburi. In addition to explanations and discussion provided earlier in these monographs, several other points need to be made. Because of the small population of small population of some district in Chonburi province, it was only feasible to provide summaries five-year average (2003-2007) for all types of cancer by districts (Table 1-22). Population Pyramids (Figure 1.0 - 11.0) and leading cancer sites by district of Chonburi (Figure 1.1 - 11.1) are Included in this Appendix.

128

Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 1.0 Population Pyramid of Muang District Chonburi, 2005

Figure 1.1 Leading cancers in Muang, Chonburi, 2003-2007

Male Female

Lung 41.1 Breast 39.4

Liver 24.4 Cervix 23.8

Colorectal 17.7 Lung 16.7

CancerProstate Site 11.6 CancerColorectal Site 13.7

Oral Cavity 7.3 Leukemia 6.9

0 10 20 30 40 50 0 10 20 30 40 50 ASR(World) ASR(World)

129

130

131 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 2.0 Population Pyramid of Ban Bung District Chonburi, 2005

Figure 2.1 Leading cancers in Ban Bung, Chonburi, 2003-2007

Male Female

Lung 30.8 Breast 28.5

Liver 18.6 Cervix 21.4

Colorectal 16.6 Lung 18.6

CancerLeukemia Site 9.2 CancerColorectal Site 7.8

Esophagus 8.3 Liver 7

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

132

133

134 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 3.0 Population Pyramid of Nong Yai District Chonburi, 2005

Figure 3.1 Leading cancers in Nong Yai, Chonburi, 2003-2007

Male Female

Lung 35.9 Cervix 29

Liver 22.3 Breast 28.7

Prostate 15.7 Gallbladder 10.9 Cancer Site CancerNasopharynx Site 8.7 Skin 10.7

Colorectal 6.2 Oral Cavity 9.8

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

135

136

137 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 4.0 Population Pyramid of Bang Lamung District Chonburi, 2005

Figure 4.1 Leading cancers in Bang Lamung, Chonburi, 2003-2007

Male Female

Lung 46.3 Cervix 40.8

Skin 26.4 Breast 37.6

Colorectal 24.8 lung 20.6

Curcer Site Liver 22.2 CancerColorectal Site 11.6

Prostate 14.6 Ovary 9.1

0 10 20 30 40 50 0 10 20 30 40 50 ASR(World) ASR(World)

138

139

140 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 5.0 Population Pyramid of Phan Thong District Chonburi, 2002

Figure 5.1 Leading cancers in Phon Thong, Chonburi, 2003-2007

Male Female

lung 37.9 Breast 25.4

Liver 21.3 Cervix 21.7

Colorectal 10.6 Lung 12.8 Cancer Site Oral Cavity 10.4 CancerColorectal Site 8.7

Bladder 8.2 Thyroid 8.6

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

138

139

140 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 6.0 Population Pyramid of Phanat Nikhom District Chonburi, 2005

Figure 6.1 Leading cancers in Phanat Nikhom, Chonburi, 2003-2007

Male Female

Lung 34.5 Breast 20.1

Liver 18.5 Cervix 18.6

Colorectal 15.6 Lung 9.5 Cancer Site CancerOral Site Cavity 9.9 Colorectal 9.2

Lymphoma 7.5 Ovary 6.1

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

141

142

143 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 7.0 Population Pyramid of Sri Racha District Chonburi, 2005

Figure 7.1 Leading cancers in Sri Racha, Chonburi, 2003-2007

Male Female

Lung 31.9 Breast 27

Liver 20 Cervix 23.5

Colorectal 10.7 Lung 10.6 Cancer Site CancerOral Site Cavity 9.3 Colorectal 8.5

Prostate 6.7 Leukemia 6.5

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

141

146

147 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 8.0 Population Pyramid of Ko Sichang District Chonburi, 2005

Figure 8.1 Leading cancers in Ko Sichang, Chonburi, 2003-2007

Male Female

Lung 67 Breast 40.5

Liver 48.4 Lung 22.1

Nose, Sinuses 15.1 Colorectal 15.9

Cancer Site Larynx 15.1 Cancer Site Ovary 15.1

Colorectal 13.3 Lymphoid 14.8

0 20 40 60 80 0 20 40 60 80 ASR(World) ASR(World)

148

149

150 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 9.0 Population Pyramid of Sattahip District Chonburi, 2005

Figure 9.1 Leading cancers in Sattahip, Chonburi, 2003-2007

Male Female

Lung 34.3 Cervix 34.8

Liver 18.6 Breast 30

Colorectal 16.8 Colorectal 16.5 Cancer Site Cancer SiteProstate 12 Lung 16.2

Bladder 7.3 Corpus 7.5

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

151

152

153 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 10.0 Population Pyramid of Bo Thong District Chonburi, 2005

Figure 10.1 Leading cancers in Bo Thong, Chonburi, 2003-2007

Male Female

Lung 35.6 Breast 28

Liver 13.1 Cervix 9.4

Colorectal 10.4 Lung 7.8

CancerOesophagus Site 9.9 Cancer Site Liver 6.3

Leukaemia 6.4 Colorectal 5.3

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

154

155

156 Appendix B

Cancer Incidence and Mortality in Chonburi, Thailand, 2003-2007

Figure 11.0 Population Pyramid of Ko Chan District Chonburi, 2005

Figure 11.1 Leading cancers in Ko Chan, Chonburi, 2003-2007

Male Female

Lung 36 Breast 30.2

Liver 26.2 Cervix 14.3

Colorectal 8.4 Colorectal 10.5 Cancer Site CancerLeukaemia Site 8 Liver 9.4

Skin 6.9 Leukaemia 7.3

0 10 20 30 40 0 10 20 30 40 ASR(World) ASR(World)

157

158

159