Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia Pichinchensis Benth
ORIGINAL ARTICLE Rec. Nat. Prod. 14:4 (2020) 276-285 Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth. Melissa Salinas 1, Nicole Bec 2, James Calva 1, Jorge Ramírez 1, José Miguel Andrade 1, Christian Larroque 3, Giovanni Vidari 4 and Chabaco Armijos 1* 1Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja, San Cayetano Alto s/n, 1101608 Loja, Ecuador 2IRMB,Univ Montpellier, INSERM, Montpellier, France 3Supportive Care Unit, Montpellier regional Cancer Instute, ICM, 34298 Montpellier, France 4TIU Research Center, Tishk International University, Erbil, Iraq (Received July 19, 2019; Revised December 21, 2019; Accepted December 24, 2019) Abstract: Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1), γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time. Keywords: Salvia pichinchensis; essential oil; GC-MS analysis; in vitro ChE inhibitory activity, cis-cadina- 1(6),4-diene. © 2020 ACG Publications. All rights reserved.
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