Outlook Science Masterclass

OUTLOOK SCIENCE MASTERCLASS 22 October 2015 / Vol 526 / Issue No 7574 22 October 2015 Supplement to Nature OUTLOOK Publishing Group journals indau is a tiny island, covering two-thirds of a square SCIENCE CONTENTS MASTERCLASS kilometre. For most of the year, its medieval streets are filled with tourists. For one week in the summer, Lhowever, the Bavarian town becomes home to an exchange S50 CELL IMAGING of ideas that circulate beyond its limits and, in the future, Beyond the limits could stretch even further. This is because Lindau is home Super-resolution microscopes are to the Nobel laureate meetings where past prize winners allowing nanoscale investigations Produced with support from: Ideas in motion meet young researchers hoping to pick up wherever their S55 Q&A Cover art: Sam Falconer illustrious mentors leave off. Memory man: Susumu Tonegawa The annual event began in 1951, two years before James S56 Q&A Editorial Watson and Francis Crick published the structure of DNA. In Herb Brody End-game winner: Elizabeth Anna Petherick 2015, it welcomed Elizabeth Blackburn (see page S56), who Blackburn studies the genetic material at the ends of chromosomes, and Michelle Grayson S58 Q&A Jenny Rooke Richard Roberts (S58), who found that genes often contain Microbe cheerleader: Richard Art & Design non-protein-coding portions that facilitate the creation of Roberts Wesley Fernandes many different proteins from a single gene. S59 Q&A Mohammed Ashour Similarly, by the first Lindau meeting, physicists had not Andrea Duffy Chance encounters: Bruce Beutler unified electromagnetism and nuclear weak forces. One of this Production year’s guests included François Englert (S61), who imagined S61 Q&A Karl Smart Boson beginnings: François Englert Ian Pope the Higgs boson. Laureates Bruce Beutler (S59) and Susumu Mira Loutfi Tonegawa (S55) — specialists in cellular immunity and Sponsorship emotional memories, respectively — are also furthering fields Reya Silao that barely existed in 1951. This Outlook illuminates all of these Yvette Smith Nobel prize winners’ discoveries. An in-depth look at super- Marketing resolution microscopy — the subject that opened this year’s Hannah Phipps Lindau meeting — describes the impact that the technology is Project Manager having on molecular and cell biology (S50). This feature and Anastasia Panoutsou the Q&A with Blackburn are accompanied by an animation; Art Director you can also hear the Q&As with Tonegawa and Beutler as a Kelly Buckheit Krause podcast (all available at www.nature.com/outlook/ Publisher masterclass2015). Richard Hughes We are pleased to acknowledge financial support from Chief Magazine Editor Mars, Incorporated in producing this Outlook. As always, Rosie Mestel Nature has sole responsibility for all editorial content. Editor-in-Chief Philip Campbell Anna Petherick Contributing editor Nature Outlooks are sponsored supplements that aim to stimulate All featured articles will be freely available for 6 months. interest and debate around a subject of interest to the sponsor, SUBSCRIPTIONS AND CUSTOMER SERVICES while satisfying the editorial values of Nature and our readers’ For UK/Europe: Nature Publishing Group, Subscriptions, Brunel expectations. The boundaries of sponsor involvement are clearly Road, Basingstoke, Hants, RG21 6XS, UK. Tel: +44 (0) 1256 329242. delineated in the Nature Outlook Editorial guidelines available at Subscriptions and customer services for Americas – including go.nature.com/e4dwzw Canada, Latin America and the Caribbean: Nature Publishing CITING THE OUTLOOK Group, 75 Varick St, 9th floor, New York, NY 10013-1917, USA. Cite as a supplement to Nature, for example, Nature Vol. XXX, Tel: +1 866 363 7860 (US/Canada) or +1 212 726 9223 (outside No. XXXX Suppl., Sxx–Sxx (2015). US/Canada). Japan/China/Korea: Nature Publishing Group — VISIT THE OUTLOOK ONLINE Asia-Pacific, Chiyoda Building 5-6th Floor, 2-37 Ichigaya Tamachi, The Nature Outlook Science Masterclass supplement can be found at Shinjuku-ku, Tokyo, 162-0843, Japan. Tel: +81 3 3267 8751. http://www.nature.com/nature/outlook/masterclass2015 CUSTOMER SERVICES It features all newly commissioned content as well as a selection of [email protected] relevant previously published material. Copyright © 2015 Nature Publishing Group 22 OCTOBER 2015 | VOL 526 | NATURE | S49 © 2015 Macmillan Publishers Limited. All rights reserved.

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