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SUPPLEMENTAL TABLE Supplementary Table 1: Candidate

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SUPPLEMENTAL TABLE Supplementary Table 1: Candidate SUPPLEMENTAL TABLE Supplementary Table 1: Candidate Genes differentially expressed in prediabetic BBdp rats Transcript Non- Prediabetic Fold Change ANOVA p- FDR p- Gene Description Cluster ID Diabetic Bi-weight (linear) value value Symbol Bi-weight Avg Signal Prediabetic Avg Signal (log2) vs Non- (log2) Diabetic 17757188 9.27 6.2 -8.4 0.023371 0.722064 Fkbp5 FK506 binding protein 5 17789572 8.49 6.47 -4.06 0.039823 0.729215 Pdk4 pyruvate dehydrogenase kinase, isozyme 4 17852156 8.48 6.54 -3.84 0.078007 0.732342 Zbtb16 zinc finger and BTB domain containing 16 17641972 5.38 3.56 -3.54 0.014342 0.722064 Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 17687609 6.72 5.38 -2.52 0.065371 0.732342 Atf3 activating transcription factor 3 17684906 7.82 6.56 -2.4 0.084143 0.736308 Rgs2 regulator of G-protein signaling 2 17731134 7.71 6.57 -2.2 0.018149 0.722064 Gnpat glyceronephosphate O-acyltransferase 17734470 6.57 5.44 -2.19 0.008916 0.722064 Fam89a family with sequence similarity 89, member A 17720472 8.27 7.22 -2.08 0.036483 0.72683 Klf6 Kruppel-like factor 6 17639774 7.68 6.65 -2.04 0.01928 0.722064 Cdc42ep2 CDC42 effector protein (Rho GTPase binding) 2; polymerase (DNA directed), alpha 2, accessory subunit 17744919 9.61 8.62 -1.99 0.037564 0.729215 Pik3r1 phosphoinositide-3- kinase, regulatory subunit 1 (alpha) 17700455 8.39 7.42 -1.96 0.05379 0.732342 Klf5 Kruppel-like factor 5 17697954 7.03 6.06 -1.95 0.026784 0.722064 Fbxo34 F-box protein 34 17678380 5.42 4.48 -1.93 0.02868 0.722064 Hrk harakiri, BCL2 interacting protein 17684316 10.84 10.02 -1.76 0.041419 0.730187 Btg2 BTG family, member 2 17686046 7.76 6.94 -1.76 0.004392 0.722064 Fmo2 flavin containing monooxygenase 2 17752346 2.46 1.66 -1.74 0.027029 0.722064 RT1-M6-1 RT1 class I, locus M6, gene 1 17881393 9.75 8.97 -1.72 0.003346 0.722064 GLUL 17646221 3.32 2.54 -1.71 0.069102 0.732342 Olr1450 olfactory receptor 1450 17759333 9.81 9.04 -1.71 0.055583 0.732342 Foxo3 forkhead box O3 17647364 9.2 8.46 -1.67 0.025845 0.722064 TMEM107 17847772 8.07 7.36 -1.64 0.006622 0.722064 Ip6k2 inositol hexakisphosphate kinase 2 17883027 5.37 4.66 -1.63 0.077281 0.732342 AC135310.2 17795854 6.93 6.23 -1.62 0.010621 0.722064 Dusp16 dual specificity phosphatase 16 17662488 9.23 8.57 -1.59 0.051287 0.732342 Ern1 endoplasmic reticulum to nucleus signaling 1 17741001 11.23 10.56 -1.59 0.013581 0.722064 Txnip thioredoxin interacting protein 17676016 7.55 6.89 -1.58 0.005564 0.722064 Cyth3 cytohesin 3 17785869 10.95 10.29 -1.58 0.01069 0.722064 Edem1 ER degradation enhancer, mannosidase alpha- like 1 17664532 2.61 1.98 -1.56 0.029095 0.722064 LOC102552046 keratin-associated protein 20-2-like 17759330 11.07 10.43 -1.56 0.033289 0.724466 Penk Pro-enkephalin 17805711 7.03 6.38 -1.56 0.021283 0.722064 Tox thymocyte selection- associated high mobility group box 17834655 7.05 6.41 -1.56 0.02218 0.722064 Tcp11l2 t-complex 11, testis- specific-like 2 17687852 7.21 6.58 -1.55 0.045978 0.730187 Rnf212 ring finger protein 212 17795938 6.65 6.03 -1.55 0.041313 0.730187 RGD156237 histone H4 variant 8 H4-v.1 17622317 7.77 7.14 -1.54 0.030248 0.722064 Tspan4 tetraspanin 4 17638514 6.32 5.69 -1.54 0.019147 0.722064 Dusp8 dual specificity phosphatase 8 17646237 3.93 3.31 -1.54 0.083104 0.736308 Olr1459 olfactory receptor 1459 17848680 8.25 7.63 -1.54 0.067672 0.732342 Ctdspl CTD (carboxy- terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 17710887 8.41 7.79 -1.53 0.014423 0.722064 Jund jun D proto-oncogene 17726397 5.94 5.33 -1.53 0.071243 0.732342 Smim3 small integral membrane protein 3 17645579 4.3 3.69 -1.52 0.041277 0.730187 Zfp354a zinc finger protein 354A 17659084 5.9 5.29 -1.52 0.034988 0.725488 Abhd15 abhydrolase domain containing 15 17863116 9.22 8.62 -1.52 0.045546 0.730187 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 17686071 6.15 5.55 -1.51 0.005172 0.722064 Fmo3 flavin containing monooxygenase 3 17627939 6.44 7.03 1.51 0.003126 0.722064 Tppp tubulin polymerization promoting protein 17820411 9.99 10.6 1.53 0.064741 0.732342 Lbh limb bud and heart development 17616411 7.15 7.77 1.54 0.003058 0.722064 Fut1 fucosyltransferase 1 17791690 5.59 6.21 1.54 0.038411 0.729215 Gprin3 GPRIN family member 3 17833309 1.53 2.16 1.54 0.004543 0.722064 LOC100912294 zinc finger protein 709-like 17755727 5.23 5.86 1.55 0.001435 0.722064 Scml4 sex comb on midleg- like 4 (Drosophila) 17752029 3.64 4.28 1.56 0.004468 0.722064 Nexn nexilin (F actin binding protein) 17801228 4.1 4.74 1.56 0.062766 0.732342 Pik3r3 phosphoinositide-3- kinase, regulatory subunit 3 (gamma) 17744336 5.13 5.79 1.58 0.073653 0.732342 Pde8b phosphodiesterase 8B 17790301 7.68 8.35 1.59 0.028942 0.722064 Tmem209 transmembrane protein 209 17615969 2.5 3.18 1.6 0.053477 0.732342 KLK1C3 17828155 5.18 5.85 1.6 0.002479 0.722064 Phlda1 pleckstrin homology- like domain, family A, member 1 17641633 3.16 3.85 1.61 0.040933 0.730187 RGD156568 similar to lipase-like, 2 ab-hydrolase domain containing 2 17821273 4.08 4.77 1.61 0.015259 0.722064 Id2 inhibitor of DNA binding 2 17724535 6.18 6.89 1.63 0.006996 0.722064 Pard6g par-6 family cell polarity regulator gamma 17805652 2.02 2.73 1.64 0.043048 0.730187 AABR07047 044.1 17625007 8.19 8.91 1.65 0.003934 0.722064 A1cf APOBEC1 complementation factor 17658675 6.25 6.98 1.65 0.000516 0.679794 Rph3al rabphilin 3A-like (without C2 domains) 17866251 4.84 5.57 1.66 0.096834 0.73658 Kcnj13 potassium channel, inwardly rectifying subfamily J, member 13 17797653 5.91 6.66 1.68 0.017921 0.722064 Epha7 Eph receptor A7 17808444 5.16 5.9 1.68 0.0281 0.722064 Fam154a family with sequence similarity 154, member A 17781980 4.69 5.44 1.69 0.000374 0.679794 Fam71f1 family with sequence similarity 71, member F1 17761922 2.71 3.48 1.71 0.027793 0.722064 Mir181a2 microRNA 181a-2 17680721 6.77 7.58 1.75 0.014723 0.722064 B3galt2 UDP-Gal:betaGlcNAc beta 1,3- galactosyltransferase, polypeptide 2 17664755 2.86 3.67 1.76 0.00488 0.722064 Mir802 microRNA 802 17799798 4.27 5.1 1.77 0.033125 0.723525 Dmrta1 DMRT-like family A1 17735357 4.66 5.5 1.78 0.00633 0.722064 Gcnt4 glucosaminyl (N- acetyl) transferase 4, core 2 17844285 6.1 6.93 1.78 0.032088 0.722064 Hykk hydroxylysine kinase 17687729 5.33 6.19 1.81 0.084738 0.736308 G0s2 G0/G1switch 2 .
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